Colorectal Cancer in 2017: From Biology to the Clinics. Rodrigo Dienstmann
|
|
- Douglas Fitzgerald
- 6 years ago
- Views:
Transcription
1 Colorectal Cancer in 2017: From Biology to the Clinics Rodrigo Dienstmann
2 MOLECULAR CLASSIFICATION Tumor cell Immune cell Tumor microenvironment Stromal cell
3 MOLECULAR CLASSIFICATION Biomarker Tumor cell Genomics Epigenomics Transcriptomics Proteomics Biomarker Immune cell Transcriptomics Proteomics Tumor microenvironment Biomarker Stromal cell Transcriptomics Proteomics
4 MOLECULAR CLASSIFICATION BRAF mutation HER2 amplification Microsatellite instability (MSI) Tumor cell Genomics Immunoscore Immune cell Proteomics Tumor microenvironment TGFβ signature Stromal cell Transcriptomics
5 BIOMARKER RESEARCH Predictive Prognostic Biology understanding
6 PRECISION MEDICINE PARADIGMS IN CRC PAST Single gene single marker single drug PRESENT Multi gene multi marker multi drug FUTURE Multi molecular multi marker adaptive (immune) multi drug Dienstmann et al, Nat Rev Cancer 2017
7 PRECISION MEDICINE PARADIGMS IN CRC PAST Single gene single marker single drug PRESENT Multi gene multi marker multi drug FUTURE Multi molecular multi marker adaptive (immune) multi drug Genomics and transcriptomics Targeted and Immuno-oncology drug development Dienstmann et al, Nat Rev Cancer 2017
8 Single gene single marker single drug Matched Targeted Agent KRAS mutation BRAF mutation PIK3CA mutation MET overexpression MEK inhibitor BRAF inhibitor PI3K inhibitor MET inhibitor Dienstmann et al, J Clin Oncol 2013
9 Single gene single marker single drug Matched Targeted Agent Response rate KRAS mutation BRAF mutation PIK3CA mutation MET overexpression MEK inhibitor BRAF inhibitor PI3K inhibitor MET inhibitor <5% Dienstmann et al, J Clin Oncol 2013
10 Single gene single marker single drug VHIO experience Dienstmann et al, Mol Cancer Ther 2012
11 HOW TO IMPROVE CLINICAL BENEFIT FURTHER? Deeper biological understanding of the disease - Genomic - Transcriptomic - Stromal-immune
12 TCGA, Nature 2012 CO-OCCURRING ALTERATIONS
13 DYNAMICS OF TARGET INHIBITION
14 CLONAL SELECTION TEMPORAL HETEROGENEITY Misale et al, Cancer Discov 2014
15 Dienstmann et al, Nat Rev Cancer 2017
16 PRECISION MEDICINE PARADIGMS IN CRC PAST Single gene single marker single drug PRESENT Multi gene multi marker multi drug FUTURE Multi molecular multi marker adaptive (immune) multi drug Dienstmann et al, Nat Rev Cancer 2017
17 Multi gene multi marker multi drug *ctdna Dienstmann et al, J Clin Oncol 2013
18 Multi gene multi marker multi drug Matched Targeted Agent KRAS, NRAS, BRAF, PIK3CA wild-type BRAF mutation ERBB2 amplification, KRAS wild-type EGFR mutation, RAS/BRAF wild-type Anti-EGFR mab BRAF inh + anti-egfr mab + MEK inh Anti-HER2 mab + pan-her inh Second generation anti-egfr mab
19 Multi gene multi marker multi drug Matched Targeted Agent BRAF mutation BRAF inhibitor + anti-egfr mab + MEK inhibitor Van Cutsem et al, ESMO-WGIC 2015
20 Multi gene multi marker multi drug Matched Targeted Agent ERBB2 amplification KRAS wild-type Anti-HER2 mab + pan-her inhibitor Siena et al, ASCO 2015
21 Multi gene multi marker multi drug Matched Targeted Agent EGFR mutation KRAS wild-type NRAS wild-type BRAF wild-type Second generation anti-egfr mab SYM004 * ** ** * * * * * * RAS/BRAF mutation * EGFR mutation Dienstmann et al, Cancer Discov 2015
22 Multi gene multi marker multi drug Matched Targeted Agent KRAS, NRAS, BRAF, PIK3CA wild-type Anti-EGFR mab Response rate BRAF mutation ERBB2 amplification, KRAS wild-type EGFR mutation, RAS/BRAF wild-type BRAF inh + anti-egfr mab + MEK inh Anti-HER2 mab + pan-her inh Second generation anti-egfr mab ~30%
23 HOW TO IMPROVE CLINICAL BENEFIT FURTHER? Deeper biological understanding of the disease - Genomic - Transcriptomic - Stromal-immune
24 Guinney, Dienstmann et al, Nat Med 2015
25 Guinney, Dienstmann et al, Nat Med 2015
26 Guinney, Dienstmann et al, Nat Med 2015
27 Supervised immune and stromal infiltration analysis CMS1 CMS2 CMS3 CMS4 Becht et al, Clin Cancer Res 2016
28 Supervised immune infiltration analysis T cell chemokine T cell inhibition Myeloid cell chemokine Angiogenesis Immunosuppression Complement CMS1 CMS2 CMS3 CMS4 Becht et al, Clin Car Res 2016
29 Dienstmann et al, Nat Rev Cancer 2017
30 Overall survival Relapse-free survival Guinney, Dienstmann et al, Nat Med 2015
31 PRECISION MEDICINE PARADIGMS IN CRC PAST Single gene single marker single drug PRESENT Multi gene multi marker multi drug FUTURE Multi molecular multi marker adaptive (immune) multi drug Dienstmann et al, Nat Rev Cancer 2017
32 Multi molecular multi marker adaptive (immune) multi drug Unpublished
33 Multi molecular multi marker adaptive (immune) multi drug
34 Lenz et al. ASCO 2017, abstr 3511
35 RIGHT vs. LEFT colon Lee et al, ASCO 2016 CMS1 enrichment < EGFR overexpression < EGFR ligand overexpression > BRAF mut > NF1/MEK1/PIK3CA/PTEN mut > MSI and CIMP high CMS2 enrichment > EGFR overexpression > EGFR ligand overexpression > IRS2 amplification < BRAF mut Guinney, Dienstmann et al, Nat Med 2015
36 Multi molecular multi marker adaptive (immune) multi drug In vitro CRC cell line drug screen HERACLES trial in HER2+ CRC HER2 GCN> 9.6 HER2 GCN< 9.6 Ragnhild A. Lothe Lab, Dept. Mol Oncol Unpublished
37 Multi molecular multi marker adaptive (immune) multi drug Predictive value hypothesis targeted therapies RAS/BRAF wt Epithelial Canonical CMS2 Strategy: anti-egfr therapy + pan-her inhibitors?
38 MSI tumors and response to PD-1 blockade PEMBROLIZUMAB NIVOLUMAB Le DT, et al. N Engl J Med 2015 Overman MJ, et al. ASCO 2016
39 Multi molecular multi marker adaptive (immune) multi drug Predictive value hypotheses immune therapies Hypermutated CRC MSI Strategy: PD1 blockade + OX40 agonist?
40 Multi molecular multi marker adaptive (immune) multi drug Predictive value hypotheses immune therapies Inflamed CRC Mesenchymal TGFβ activated CMS4 Strategy: PD1 blockade + TGFBR inh or angiogenic multi-tki MSS
41 Multi molecular multi marker adaptive (immune) multi drug Predictive value hypotheses immune therapies Immune desert CRC Strategy: PD1 blockade + MEK inh or epigenetic therapy or T cell bispecific mab (CEA-CD3)? Epithelial CMS2 MSS Metabolic CMS3
42 Atezolizumab (PDL1 block) + cobimetinib (MEK inh) in mcrc Bendell et al, ASCO 2016
43 Predictive value hypotheses immune therapies Becht et al. Advances Immunol 2016
44 MoTriColor project H2020 FFPE gene expr. classifier
45 How to translate this hypotheses to clinical practice? CMS classifier CINICAL LAB : NanoString, IHC panels RESEARCH LAB: Almac, many others - NOW: Retrospective analysis of clinical trials with standard regimens - NEXT: Stratification in ongoing trials with immuno-oncology drugs - FUTURE: Drug repurposing and novel-novel combinations = targeting pathway dependencies
46 How to translate this hypotheses to clinical practice? - Retrospective analysis of clinical trials with standard regimens ASCO 2018 Tuesday 9:45 am Clinical Science Symposium oral session Clinical utility of colon cancer molecular subtypes: Validation of two main colorectal molecular classifications on the PETACC-8 phase III trial cohort Consensus molecular subgroups (CMS) of colorectal cancer (CRC) and first-line efficacy of FOLFIRI plus cetuximab or bevacizumab in the FIRE3 trial. Impact of consensus molecular subtyping (CMS) on overall survival (OS) and progression free survival (PFS) in patients (pts) with metastatic colorectal cancer (mcrc): Analysis of CALGB/SWOG (Alliance).
47 How to translate this hypotheses to clinical practice? - NEXT: Stratification in ongoing trials with immuno-oncology drugs - FUTURE: Drug repurposing and novel-novel combinations = targeting pathway dependencies
48 TAKE HOME MESSAGES Dienstmann et al, Nat Rev Cancer 2017
49 TAKE HOME MESSAGES Dienstmann et al, Nat Rev Cancer 2017
50 PREDICTIVE Still unknown what combination of molecular markers (mutation + MSI + gene/protein expression) will provide the best prediction of drug response.
51 Gastrointestinal Tumors Group Molecular Prescreening Program Molecular Therapeutics Unit ODysSey Group Ragnhild A. Lothe Scott Kopetz Justin Guinney Josep Tabernero
52 Marisa et al. ASCO 2017, abstr 3509
53 Stintzing et al. ASCO 2017, abstr 3510
Colorectal Cancer in the Coming Years: What Can We Expect?
Colorectal Cancer in the Coming Years: What Can We Expect? Clara Montagut, MD, PhD Hospital Universitari del Mar, Barcelona, Spain Memorial Sloan Kettering Cancer Center, New York, United States What Are
More informationTHE FUTURE OF IMMUNOTHERAPY IN COLORECTAL CANCER. Prof. Dr. Hans Prenen, MD, PhD Oncology Department University Hospital Antwerp, Belgium
THE FUTURE OF IMMUNOTHERAPY IN COLORECTAL CANCER Prof. Dr. Hans Prenen, MD, PhD Oncology Department University Hospital Antwerp, Belgium DISCLAIMER Please note: The views expressed within this presentation
More informationBiomarkers in Imunotherapy: RNA Signatures as predictive biomarker
Biomarkers in Imunotherapy: RNA Signatures as predictive biomarker Joan Carles, MD PhD Director GU, CNS and Sarcoma Program Department of Medical Oncology Vall d'hebron University Hospital Outline Introduction
More informationMolecular subtyping: how useful is it?
Molecular subtyping: how useful is it? Daniela E. Aust, Institute for Pathology, University Hospital Dresden, Germany Center for Molecular Tumor Diagnostics at the NCT-Partner Site Dresden CMTD Disclosure
More informationINMUNOTERAPIA EN CANCER COLORRECTAL METASTASICO. CCRm MSI-H NUEVO ESTANDAR EN PRIMERA LINEA Y/O PRETRATADOS?
INMUNOTERAPIA EN CANCER COLORRECTAL METASTASICO CCRm MSI-H NUEVO ESTANDAR EN PRIMERA LINEA Y/O PRETRATADOS? V. Alonso Servicio de Oncologia Medica H. U. Miguel Servet Zaragoza MSI-H mcrc Clinical and Pathological
More informationNovel Molecularly Targeted Therapies and Biomarkers in Advanced Colorectal Cancer. Objectives
Novel Molecularly Targeted Therapies and Biomarkers in Advanced Colorectal Cancer Michael S. Lee, MD Assistant Professor of Medicine University of North Carolina Objectives Discuss important clinicopathologic
More informationMETASTATIC COLORECTAL CANCER: TUMOR MUTATIONAL ANALYSIS AND ITS IMPACT ON CHEMOTHERAPY SUMA SATTI, MD
METASTATIC COLORECTAL CANCER: TUMOR MUTATIONAL ANALYSIS AND ITS IMPACT ON CHEMOTHERAPY SUMA SATTI, MD INTRODUCTION Second leading cause of cancer related death in the United States. 136,830 cases in 2014
More informationMSI and other molecular markers: how useful are they? Daniela E. Aust, Institute for Pathology, University Hospital Dresden, Germany
MSI and other molecular markers: how useful are they? Daniela E. Aust, Institute for Pathology, University Hospital Dresden, Germany Disclosure slide I Member of advisory boards for AMGEN, ROCHE I Speaker
More informationColon Cancer: State of the Art
Colon Cancer: State of the Art Heinz-Josef Lenz Professor of Medicine and Preventive Medicine Associate Director, Clinical Research J Terrence Lanni Chair in Cancer Research Co-Director, USC Center for
More informationImmunotherapy for dmmr metastatic colorectal cancer. Prof.dr. Kees Punt Dept. Medical Oncology AUMC
Immunotherapy for dmmr metastatic colorectal cancer Prof.dr. Kees Punt Dept. Medical Oncology AUMC Active specific immunotherapy (ASI) in stage II-III colon cancer Vaccination with autologous tumor + BCG
More informationReview of the ESMO consensus conference on metastatic CRC Basis strategies ad groups (RAS, BRAF, etc) Michel Ducreux
Review of the ESMO consensus conference on metastatic CRC Basis strategies ad groups (RAS, BRAF, etc) Michel Ducreux 2 ESMO consensus on mcrc 2016 Chairs: Co-Chairs of working groups E Van Cutsem A Sobrero
More informationImmunotherapy in Colorectal cancer
Immunotherapy in Colorectal cancer Ahmed Zakari, MD Associate Professor University of Central Florida, College of Medicine Medical Director, Gastro Intestinal Cancer Program Florida Hospital Cancer Institute
More informationValidated and promising predictive factors in mcrc: Recent updates on RAS testing Fotios Loupakis, MD PhD
Validated and promising predictive factors in mcrc: Recent updates on RAS testing Fotios Loupakis, MD PhD U.O. Oncologia 2 Universitaria Azienda Ospedaliero-Universitaria Pisana Pisa, Italy Learning Objectives
More informationCURRENT STANDARD OF CARE OF COLORECTAL CANCER: THE EVOLUTION OF ESMO CLINICAL PRACTICE GUIDELINES
CURRENT STANDARD OF CARE OF COLORECTAL CANCER: THE EVOLUTION OF ESMO CLINICAL PRACTICE GUIDELINES Fortunato Ciardiello ESMO Past-President 2018-2019 Dipartimento di Medicina di Precisione Università degli
More informationColon cancer: Highlights. Filippo Pietrantonio Istituto Nazionale dei Tumori di Milano
Colon cancer: Highlights Filippo Pietrantonio Istituto Nazionale dei Tumori di Milano Agenda 1) Metastatic colorectal cancer First-line treatment molecularly unselected: FOLFOXIRI-bev (CHARTA trial) Later-line
More informationMicrosatellite instability and other molecular markers: how useful are they?
Microsatellite instability and other molecular markers: how useful are they? Pr Frédéric Bibeau, MD, PhD Head, Pathology department CHU de Caen, Normandy University, France ESMO preceptorship, Barcelona,
More informationTherapeutic Options for Patients with BRAF-mutant Metastatic Colorectal Cancer
Therapeutic Options for Patients with BRAF-mutant Metastatic Colorectal Cancer Axel Grothey, M.D., Professor of Oncology, Clinical and Translational Science Division of Medical Oncology Mayo Clinic, Rochester,
More informationXXV Corso Nazionale TSLB: evoluzione o ri(e)voluzione?
XXV Corso Nazionale TSLB: evoluzione o ri(e)voluzione? Marcatori predittivi di efficacia nel carcinoma del colon: DESTRO verso SINISTRO conta? Dott. Matteo Clavarezza S.C. Oncologia Medica RAS metastatic
More informationAIOM GIOVANI Perugia, Luglio 2017
AIOM GIOVANI 2017 Perugia, 07-08 Luglio 2017 Scelta delle linee successive nel paziente RAS e BRAF wild-type con particolare accento su nuovi bersagli terapeutici Francesca Battaglin U.O.C. Oncologia Medica
More informationColon cancer: ASCO poster review. Alfonso De Stefano MD, PhD SC Oncologia Clinica Sperimentale Addome
Colon cancer: ASCO poster review Alfonso De Stefano MD, PhD SC Oncologia Clinica Sperimentale Addome a.destefano@istitutotumori.na.it 255 poster examined: my selection Clinical Practice Translational &
More informationIMMUNOTHERAPY: WHO AND WHEN? Elena Elez MD, PhD Colon Cancer Program Vall d Hebron Institute of Oncology (VHIO)
IMMUNOTHERAPY: WHO AND WHEN? Elena Elez MD, PhD Colon Cancer Program Vall d Hebron Institute of Oncology (VHIO) meelez@vhio.net CHALLENGING IMMUNO IN CRC: Sometimes when you innovate, you make mistakes.
More informationReview of the ESMO consensus conference on metastatic colorectal cancer Basic strategies and groups. Chemotherapy and targeted agents in 1st line
ESMO Preceptorship Programme Colorectal Cancer Valencia, 18th May 2018 Review of the ESMO consensus conference on metastatic colorectal cancer Basic strategies and groups Chemotherapy and targeted agents
More informationPrognostic significance of K-Ras mutation rate in metastatic colorectal cancer patients. Bruno Vincenzi Università Campus Bio-Medico di Roma
Prognostic significance of K-Ras mutation rate in metastatic colorectal cancer patients Bruno Vincenzi Università Campus Bio-Medico di Roma Colorectal cancer 3 rd most common cancer worldwide Approximately
More informationAdjuvant/neoadjuvant systemic treatment of colorectal cancer
5th ESO-ESMO Eastern Europe and Balkan Region Masterclass in Medical Oncology Belgrade, June 19 th 2018 Adjuvant/neoadjuvant systemic treatment of colorectal cancer Carlotta Antoniotti Polo Oncologico
More informationDOES LOCATION MATTER IN COLORECTAL CANCER: LEFT VS RIGHT?
DOES LOCATION MATTER IN COLORECTAL CANCER: LEFT VS RIGHT? By: Dr. Dominik Modest, Medical Department III, Hospital of the University of Munich, Germany Dr. Andrea Sartore-Bianchi, Niguarda Cancer Center,
More informationColorectal Cancer: Lumping or Splitting? Jimmy J. Hwang, MD FACP Levine Cancer Institute Carolinas HealthCare System Charlotte, NC
Colorectal Cancer: Lumping or Splitting? Jimmy J. Hwang, MD FACP Levine Cancer Institute Carolinas HealthCare System Charlotte, NC 2 Epidemiology Colorectal Cancer is the 2 nd Leading Cause of Cancer-related
More informationKolorektalni karcinom- novosti u liječenju. PANEL: Maja Banjin, Janja Ocvirk, Borislav Belev, Ivan Nikolić, Anes Pašić
Kolorektalni karcinom- novosti u liječenju PANEL: Maja Banjin, Janja Ocvirk, Borislav Belev, Ivan Nikolić, Anes Pašić Kolorektalni karcinomnovosti u liječenju PANEL : Maja Banjin, Janja Ocvirk, Borislav
More informationANTI-EGFR IN MCRC? Assoc. Prof. Gerald Prager, Medical University of Vienna, Austria
IS IT TIME TO RE-CHALLENGE ANTI-EGFR IN MCRC? Assoc. Prof. Gerald Prager, Medical University of Vienna, Austria Dr. Andrea Sartore-Bianchi, Oncologia Clinica Molecolare, Niguarda Cancer Center, Milano,
More informationThe left versus right colon cancer story What is the truth?
The left versus right colon cancer story What is the truth? Prof. V. Heinemann CCC LMU, Klinikum Grosshadern Ludwig-Maximilian-University of Munich, Germany Three stages of truth (Schopenhauer) Ridicule
More informationADVANCES IN COLON CANCER
ADVANCES IN COLON CANCER Peter T. Silberstein, M.D., FACP Professor, Creighton University Chief Hematology/Oncology UNIVERSAL SCREENING FOR LYNCH SYNDROME OF ALL PATIENTS WITH COLON CANCER ADOPTED BY CHI
More informationIMMUNOTHERAPY FOR GASTROINTESTINAL CANCERS
IMMUNOTHERAPY FOR GASTROINTESTINAL CANCERS Dr Elizabeth Smyth Royal Marsden Hospital ESMO Colorectal Cancer Preceptorship Valencia 2018 DISCLOSURES Honoraria for advisory role Servier, Celgene, BMS, Five
More informationColon Cancer ASCO Poster Review
Rome, February 11 th 2017 AIOM POST ASCO GI Review Colon Cancer ASCO Poster Review Lisa Salvatore UOC Oncologia Policlinico GB Rossi Azienda Ospedaliero Universitaria Integrata di Verona Me Before Me After
More informationPost-ASCO Immunotherapy Highlights (Part 2): Biomarkers for Immunotherapy
Post-ASCO Immunotherapy Highlights (Part 2): Biomarkers for Immunotherapy Lee S. Schwartzberg, MD, FACP Chief, Division of Hematology Oncology; Professor of Medicine, The University of Tennessee; The West
More informationDaniele Santini University Campus Bio-Medico Rome, Italy
Daniele Santini University Campus Bio-Medico Rome, Italy Anti EGFR therapy and colorectal cancer Cetuximab or Panitumumab Adapted from Ciardiello F. and Tortora G. NEJM 2008;358:1160-74 Who will benefit
More informationIMMUNOTHERAPY FOR GASTROINTESTINAL CANCERS
IMMUNOTHERAPY FOR GASTROINTESTINAL CANCERS Dr Elizabeth Smyth Cambridge University Hospitals NHS Foundation Trust ESMO Gastric Cancer Preceptorship Valencia 2018 DISCLOSURES Honoraria for advisory role
More informationJY Douillard MD, PhD Professor of Medical Oncology
Colorectal Cancer ESMO Preceptorship Program Prague May 22-23rd 2014 Review of the ESMO Consensus Conference on metastatic colo-rectal cancer Basic strategy and groups (RASwt/mut, BRAF mut) JY Douillard
More informationOPTIMISING OUTCOMES FOR PATIENTS WITH ADVANCED COLORECTAL CANCER
OPTIMISING OUTCOMES FOR PATIENTS WITH ADVANCED COLORECTAL CANCER E-Learning Module Stavros Gkolfinopoulos 1, Demetris Papamichael 1, George Pentheroudakis 2 1. Cyprus Oncology Centre, Nicosia, Cyprus 2.
More information1ª línea continuum of care:
1ª línea continuum of care: maximizando la SG en CCRm RAS wt (Cetuximab) Ramon Salazar Institut Català d Oncologia Sequence of treatment Chemotherapy sequence (folfiri/folfox) 1 Detrimental effect when
More informationNOVITA IN TEMA DI TERAPIA DEL CARCINOMA DEL COLON-RETTO
Congresso AIOM Giovani Perugia, 9 luglio 2016 NOVITA IN TEMA DI TERAPIA DEL CARCINOMA DEL COLON-RETTO Carlotta Antoniotti Polo Oncologico Azienda Ospedaliero-Universitaria Pisana Università di Pisa What
More informationHow to treat a patient with metastatic CRC? Towards personalized treatment strategies
How to treat a patient with metastatic CRC? Towards personalized treatment strategies Prof Eric Van Cutsem, MD, PhD Digestive Oncology Leuven, Belgium Eric.VanCutsem@uzleuven.be Progress in the treatment
More informationPredicting outcome in metastatic breast cancer
Predicting outcome in metastatic breast cancer Aleix Prat, MD, PhD Medical Oncology Department Translational Genomics and Targeted Therapeutics in Solid Tumors Monday, 15 th January, Manchester, UK Disclosures
More informationHeavilyTreated mcrc..whats next?
ESMO Preceptorship Programme Gastrointestinal Cancer 20-22 October 2016,Singapore Dr Surendra Pal Chaudhary Dept of Medical Oncology Dr BR Ambedkar Instituite Rotary Cancer Hospital All India Institute
More informationManaging mcrc Across Disease Continuum: Front-Line Therapy and Treatment Beyond Progression
Managing mcrc Across Disease Continuum: Front-Line Therapy and Treatment Beyond Progression Guillermo Méndez, MD Sección Oncología Hospital de Gastroenterología Bonorino Udaondo Carlos B. Udaondo y Fundación
More informationMolecular Biomarkers in the Characterization & Treatment of Colorectal Carcinoma
Molecular Biomarkers in the Characterization & Treatment of Colorectal Carcinoma Andrew C. Nelson, M.D., Ph.D. Divisions of Anatomic & Molecular Pathology Department of Laboratory Medicine & Pathology
More informationImmunoterapia en Cáncer colorrectal. Manuel Benavides
Immunoterapia en Cáncer colorrectal Manuel Benavides Agenda - Cáncer colorrectal / MSI - MSI-H / MSI-L o MSI-S - Inhibidores de Checkpoints Molecular Pathways in Colorectal Cancer tability or MSI (15%)
More informationPrecision Genetic Testing in Cancer Treatment and Prognosis
Precision Genetic Testing in Cancer Treatment and Prognosis Deborah Cragun, PhD, MS, CGC Genetic Counseling Graduate Program Director University of South Florida Case #1 Diana is a 47 year old cancer patient
More informationMÁS ALLA DE LA PRIMERA LÍNEA: SECUENCIA DE TRATAMIENTO. Dra. Ruth Vera Complejo Hospitalario de Navarra
MÁS ALLA DE LA PRIMERA LÍNEA: SECUENCIA DE TRATAMIENTO Dra. Ruth Vera Complejo Hospitalario de Navarra GOALS Prolongation of survival Cure Improving tumour-related symptoms Stopping tumour progression
More informationManagement of Patients with Colorectal Cancer
Management of Patients with Colorectal Cancer Elsevier Office of Continuing Medical Education Independent Conference Highlights of the ASCO-GI 2018 Symposium Disclaimer The views expressed in the following
More informationOut of 129 patients with NSCLC treated with Nivolumab in a phase I trial, the OS rate at 5-y was about 16 %, clearly higher than historical rates.
6th Meeting on external quality assessment in molecular pathology, Naples, May 12-13, 2017 Overview of clinical development of checkpoint inhibitors in solid tumors Pr Jaafar BENNOUNA University of Nantes
More informationBasket Trials: Features, Examples, and Challenges
: Features, s, and Challenges Lindsay A. Renfro, Ph.D. Associate Professor of Research Division of Biostatistics University of Southern California ASA Biopharm / Regulatory / Industry Statistics Workshop
More informationRecent Advances in Gastrointestinal Cancers
Recent Advances in Gastrointestinal Cancers Ursina R. Teitelbaum, MD Section of Hematology/Oncology Abramson Cancer Center PENN 2016 Updates in Oncology June 23, 2016 none Disclosures ASCO 2016 Highlights:
More informationMicrosatellite instability and other molecular markers: how usefulare they? Pr Frédéric Bibeau, MD, PhD Pathology Department CHU de Caen France
Microsatellite instability and other molecular markers: how usefulare they? Pr Frédéric Bibeau, MD, PhD Pathology Department CHU de Caen France Content - Colorectal cancer context - CRC molecular classification
More informationBRAF Testing In The Elderly: Same As in Younger Patients?
EGFR, K-RAS, K BRAF Testing In The Elderly: Same As in Younger Patients? Nadine Jackson McCleary MD MPH Gastrointestinal Oncology Dana-Farber/Harvard Cancer Care Boston, MA, USA Outline Colorectal cancer
More informationRight Drug for the Right Colorectal Patient: Select the Best Initial Therapy and What Comes After 5-FU/OXALI/IRINO?
Right Drug for the Right Colorectal Patient: Select the Best Initial Therapy and What Comes After 5-FU/OXALI/IRINO? Axel Grothey Professor of Oncology Minnesota -> Tennessee The Luxury of So Many Options...
More informationTreatment of Advanced Colorectal Cancer
Treatment of Advanced Colorectal Cancer Alexis D. Leal, M.D. Assistant Professor, GI Medical Oncology University of Colorado Cancer Center Disclosures None Objectives Review the basics of advanced colorectal
More informationEmerging Tissue and Serum Markers
Emerging Tissue and Serum Markers for Immune Checkpoint Inhibitors Kyong Hwa Park MD, PhD Medical Oncology Korea University College of Medicine Contents Immune checkpoint inhibitors in clinical practice
More informationADVANCED COLORECTAL CANCER: UNRESECTABLE OR BORDERLINE RESECTABLE (GROUP 1) CHEMOTHERAPY +/- TARGETED AGENTS. Andrés Cervantes. Professor of Medicine
ADVANCED COLORECTAL CANCER: UNRESECTABLE OR BORDERLINE RESECTABLE (GROUP 1) CHEMOTHERAPY +/- TARGETED AGENTS Andrés Cervantes Professor of Medicine 1995 One option Advances in the treatment of mcrc 2000
More informationIntegration of Cancer Genome into GECCO- Genetics and Epidemiology of Colorectal Cancer Consortium
Integration of Cancer Genome into GECCO- Genetics and Epidemiology of Colorectal Cancer Consortium Ulrike Peters Fred Hutchinson Cancer Research Center University of Washington U01-CA137088-05, PI: Peters
More informationASCO 2017 updates in Colorectal and Gastric Cancers. May Cho, M.D.
ASCO 2017 updates in Colorectal and Gastric Cancers May Cho, M.D. Relevant financial relationships in the past twelve months by presenter or spouse/partner: None The speaker will directly disclosure the
More informationAdvances in Immunotherapy in the Treatment of Colorectal Cancer
Advances in Immunotherapy in the Treatment of Colorectal Cancer Birendra KC, MD; Jimmy J. Hwang, MD; Carol J. Farhangfar, PhD, MBA; and S. Jean Chai, MD Abstract Colorectal cancer (CRC) remains the third
More informationLiquid Biopsy. Jesus Garcia-Foncillas MD PhD. Director
Liquid Biopsy Jesus Garcia-Foncillas MD PhD Director Main issues about liquid biopsies New paradigm: Precision Medicine Heterogeneity & Dynamics Surrogate mirror for the tumor CTCs in colon cancer ctdna:
More informationAbetter understanding of the tumor biology of colorectal cancer has led to. Beyond the second line
Beyond the second line of the care continuum in metastatic colorectal cancer In first-line treatment, a deep response on the tumor load is the primary aim to improve patient prognosis; however, in later
More informationGiorgio V. Scagliotti Università di Torino Dipartimento di Oncologia
Giorgio V. Scagliotti Università di Torino Dipartimento di Oncologia giorgio.scagliotti@unito.it Politi K & Herbst R. Clin. Cancer Res. 2015; 21:2213 Breast Colorectal Gastric/GE Junction Tumor Type Head
More informationObjectives. Briefly summarize the current state of colorectal cancer
Disclaimer I do not have any financial conflicts to disclose. I will not be promoting any service or product. This presentation is not meant to offer medical advice and is not intended to establish a standard
More informationKeynote Presentation I New Era of CRC Management: Impact of Tumor Sidedness and Molecular Subtypes of CRC
Keynote Presentation I New Era of CRC Management: Impact of Tumor Sidedness and Molecular Subtypes of CRC Scott Kopetz, MD, PhD, FACP University of Texas MD Anderson Cancer Center Houston, Texas, United
More informationAshita Waterston Beatson West of Scotland Cancer Centre
Ashita Waterston Beatson West of Scotland Cancer Centre Aim of treatment Scheduling and choice of treatments are dictated by aim: Down staging for resectability: upfront intensive Prolong survival: combination
More informationMolecular biology of colorectal cancer
Molecular biology of colorectal cancer Phil Quirke Yorkshire Cancer Research Centenary Professor of Pathology University of Leeds, UK Rapid pace of molecular change Sequencing changes 2012 1,000 genomes
More informationFOCUS4 A molecularly stratified randomised controlled trial programme (and a novel trial design for targeted therapies)
FOCUS4 A molecularly stratified randomised controlled trial programme (and a novel trial design for targeted therapies) R Kaplan MRC Clinical Trials Unit at UCL, London Fundamental challenges in oncology
More informationToxicity by Age Group. Old Factor 1: Age. Disclosures. Predicting survival in metastatic colorectal cancer. Personalized Medicine - Decision Tools -
Disclosures Predicting survival in metastatic colorectal cancer Daniel Sargent, PhD Mayo Clinic Consulting activities Amgen Pfizer Roche/Genentech Sanofi-Aventis Genomic Health Personalized Medicine -
More informationThe Role of Immuno-Oncology Biomarkers in Lung Cancer
The Role of Immuno-Oncology Biomarkers in Lung Cancer Vamsidhar Velcheti, MD, FACP Staff Physician, Associate Director Center for Immuno-Oncology Research Taussig Cancer Institute Cleveland Clinic November
More informationJY Douillard MD, PhD Professor of Medical Oncology
ESMO Preceptorship Colorectal Cancer Colorectal ESMO Cancer Preceptorship Vienna 26-27 Program October 2015 Prague May 22-23rd 2014 Review of the ESMO Consensus Conference on metastatic colo-rectal cancer
More informationCONSIDERATIONS IN DEVELOPMENT OF PEMBROLIZUMAB IN MSI-H CANCERS
CONSIDERATIONS IN DEVELOPMENT OF PEMBROLIZUMAB IN MSI-H CANCERS December 2017 Christine K. Gause, Ph.D Executive Director, Biostatistics. 2 Microsatellite Instability-High Cancer - USPI KEYTRUDA is indicated
More informationColon Cancer Molecular Target Agents
Colon Cancer Molecular Target Agents Ci Caio Max SR S. Rocha Lima, M.D. MD Professor of Medicine CDi CoDiretor Cl Colorectal tlheptobiliary, Pancreatic SDG, and Phase I Unit University of Miami & Silvester
More informationImmunotherapy in gastrointestinal cancer will improve patient outcome!
Immunotherapy in gastrointestinal cancer will improve patient outcome! Checkpoint inhibitors under evaluation Summary of recent data from ASCO and ASCO GI Markus Moehler University Medical Center Mainz,
More informationSupplementary Online Content
Supplementary Online Content Venook AP, Niedzwiecki D, Lenz H-J, et al. Effect of first-line chemotherapy combined with cetuximab or bevacizumab on overall survival in patients with KRAS wild-type advanced
More informationGenomic tests to personalize therapy of metastatic breast cancers. Fabrice ANDRE Gustave Roussy Villejuif, France
Genomic tests to personalize therapy of metastatic breast cancers Fabrice ANDRE Gustave Roussy Villejuif, France Future application of genomics: Understand the biology at the individual scale Patients
More informationCTC in clinical studies: Latest reports on GI cancers
CTC in clinical studies: Latest reports on GI cancers François-Clément Bidard, MD PhD GI cancers are characterized by Multimodal treatment strategies Treatments are adapted to tumor burden & prognosis
More informationFirst line treatment in metastatic colorectal cancer
First line treatment in metastatic colorectal cancer Claus-Henning Köhne University Clinic Onkology and Haematology North West German Cancer Center (NWTZ) A non authorised version of ESMO guidelines was
More informationNSCLC 2 nd and further line therapies. Egbert F. Smit MD PhD. Dept. Thoracic Oncology, Netherlands Cancer Institute
NSCLC 2 nd and further line therapies Egbert F. Smit MD PhD. Dept. Thoracic Oncology, Netherlands Cancer Institute e.smit@nki.nl ESMO Guidelines 2016: Treatment of Stage IV nonsquamous NSCLC at progression
More informationHow I Treat Metastatic Colorectal Cancer
September 2018 Volume 16, Issue 9, Supplement 18 How I Treat Metastatic Colorectal Cancer Tanios Bekaii-Saab, MD Professor, Mayo Clinic College of Medicine and Science Program Leader, GI Program Mayo Clinic
More informationCOLORECTAL CANCER: STATE OF THE ART
COLORECTAL CANCER: STATE OF THE ART Andrés Cervantes Professor of Medicine DECLARATION OF INTERESTS Consulting and advisory services, speaking or writing engagements, public presentations Merck Serono
More informationCarcinoma colorettale: personalizzazione del trattamento
33 Incontro Oncologico del Triveneto Padova, Aprile 2017 Carcinoma colorettale: personalizzazione del trattamento Fotios Loupakis, MD PhD U.O.C. Oncologia Medica 1 Dipartimento di Oncologia Clinica e Sperimentale
More informationLa strategia terapeutica per il trattamento del carcinoma del colon-retto metastatico
VI Corso Nazionale Eventi Formativi AIOM-SIAPEC Roma,15 Giugno 2016 La strategia terapeutica per il trattamento del carcinoma del colon-retto metastatico Francesco Di Costanzo Direttore SC Oncologia Medica
More informationΚίκα Πλοιαρχοπούλου. Παθολόγος Ογκολόγος Ευρωκλινική Αθηνών
Κίκα Πλοιαρχοπούλου Παθολόγος Ογκολόγος Ευρωκλινική Αθηνών Time (months) Survival outcomes in mcrc have progressively improved over the past two decades Treatment options for many patients Multidisciplinary
More informationREVIEW ON THE ESMO CONSENSUS CONFERENCE ON ADVANCED COLORECTAL CANCER
ESMO Preceptorship Programme Colorectal Cancer Barcelona November, 25-26, 2016 REVIEW ON THE ESMO CONSENSUS CONFERENCE ON ADVANCED COLORECTAL CANCER Andrés Cervantes Professor of Medicine Strategic changes
More informationColorectal Cancer: Critical review
AIOM POST-ASCO 2018 Updates and Review from Chicago Milano, June 15-16, 2018 Colorectal Cancer: Critical review Alfredo Falcone, MD Department of Oncology and Translational Medicine University of Pisa
More informationThe evolving role of immune oncology in colorectal cancer
Review Article Page 1 of 10 The evolving role of immune oncology in colorectal cancer Shaheenah Dawood Department of Medical Oncology, Mediclinic City Hospital, Comprehensive Cancer Center, Dubai Health
More informationRAS and BRAF in metastatic colorectal cancer management
Review Article RAS and BRAF in metastatic colorectal cancer management Jun Gong 1, May Cho 1, Marwan Fakih 2 1 Department of Medical Oncology, City of Hope National Medical Center, Duarte, CA, USA; 2 Medical
More informationMEETING SUMMARY ESMO 2018, Munich, Germany. Dr. Jenny Seligmann University of Leeds, UK HIGHLIGHTS ON COLORECTAL CANCER
MEETING SUMMARY ESMO 2018, Munich, Germany Dr. Jenny Seligmann University of Leeds, UK HIGHLIGHTS ON COLORECTAL CANCER DISCLAIMER Please note: The views expressed within this presentation are the personal
More informationMetastatic Colorectal Cancer : The role of Personalised Medicine, Biomarkers and Early tumour shrinkage. Dr Lee-Ann Jones
Metastatic Colorectal Cancer : The role of Personalised Medicine, Biomarkers and Early tumour shrinkage Dr Lee-Ann Jones Aim Metastatic Colorectal Cancer: Past: 5FU, oxaliplatin, irinotecan..blanket treatment
More informationUnraveling Immunotherapy for Colorectal Cancer
Unraveling Immunotherapy for Colorectal Cancer Todd S. Crocenzi, M.D. Providence Cancer Center/ Earle A. Chiles Research Institute Portland, OR 1 Disclosures Research Support: Bristol-Myers Squibb Research
More informationMarcatori biomolecolari dei carcinomi del colon-retto sporadici ed ereditari
Marcatori biomolecolari dei carcinomi del colon-retto sporadici ed ereditari Milo Frattini XII Congresso AIFEG Villa Cagnola - Gazzada Schianno (VA) 16/17.10.2014 APC β-catenina APC Met (p16) Models of
More informationClinical Biomarker in Kidney Cancer. Maria Nirvana Formiga, M.D., Ph.D.
Clinical Biomarker in Kidney Cancer Maria Nirvana Formiga, M.D., Ph.D. Disclosures I am on the Speaker s Bureau with Pfizer and Bayer Clinical trials of BMS and Pfizer Kidney Cancer 70% new cases in developed
More informationLiquid biopsies to track clonal evolution and resistance to EGFR inhibition in mcrc
Liquid biopsies to track clonal evolution and resistance to EGFR inhibition in mcrc Alberto Bardelli Candiolo Cancer Center IRCCs University of Torino - Medical School Disclosures Horizon discovery Biocartis
More informationThe use of diagnostic FFPE material in cancer epidemiology research
The use of diagnostic FFPE material in cancer epidemiology research Neil O Callaghan Genetic Epidemiology Laboratory Department of Pathology The University of Melbourne www.pedigree.org.au Overview Who
More informationThird Line and Beyond: Management of Refractory Colorectal Cancer
Third Line and Beyond: Management of Refractory Colorectal Cancer George A. Fisher MD PhD Stanford University 1 Overview Defining the chemo refractory and intolerant Agents approved in 3 rd line setting
More informationMedical Therapy of Colorectal Cancer in the Biomarker Era
Medical Therapy of Colorectal Cancer in the Biomarker Era Axel Grothey Professor of Oncology Mayo Clinic College of Medicine Rochester, Minnesota Disclosures Consulting activities (honoraria went to the
More informationColon Cancer Update Christie J. Hilton, DO
POMA Winter Conference Christie Hilton DO Medical Oncology January 2018 None Colon Cancer Numbers Screening (brief update) Practice changing updates in colon cancer MSI Testing Immunotherapy in Colon Cancer
More informationTHE ROLE OF PREDICTIVE AND PROGNOSTIC MARKERS IN COLORECTAL CANCER
THE ROLE OF PREDICTIVE AND PROGNOSTIC MARKERS IN COLORECTAL CANCER Cathy Eng, M.D., F.A.C.P. Associate Professor Associate Medical Director, Colorectal Center Dept of GI Medical Oncology November 5, 2010
More informationTargets & therapies for colorectal cancer
Targets & therapies for colorectal cancer Jan Schellens Werkgroep "MOLECULAIRE DIAGNOSTIEK IN DE PATHOLOGIE 31-01-2014 Current treatment options for advanced colorectal cancer (CRC) First line: - CAPOX
More information