Management options for high-risk, BCG-refractory NMIBC. Alan M. Nieder, M.D. Columbia University Division of Urology Mount Sinai Medical Center
|
|
|
- Ashlyn Holmes
- 6 years ago
- Views:
Transcription
1 Management options for high-risk, BCG-refractory NMIBC Alan M. Nieder, M.D. Columbia University Division of Urology Mount Sinai Medical Center
2 Bladder Cancer in U.S. 4 th most common cancer in men 9 th most common cancer in women 60,000 cases/year newly diagnosed 12,000 deaths/year Florida 4 th most populous state (>17 million)
3 Only a slight decline in the overall incidence of BC in Florida over the last 25 years Only a slight decline in the % of advanced BC Lowest rates of reduction in white & black females Rates of advanced BC are similar in blacks & whites despite substantially lower over all rates in blacks Only a minimal decline in the BC mortality rates for Black and Whites, but not Hispanics Nieder et al. Journal of Urology, 2008.
4 Results: BC mortality Rate per 100, Diagnosis Year Hispanic Male Hispanic Female Black Female White Female Black Male White Male Nieder et al. Journal of Urology, 2008.
5 How to improve BC outcomes 1. Prevention 2. Increasing awareness/education 3. Early identification of BC 4. Improved stratification 5. Aggressive treatment of high-risk BC 6. Improved surgical treatment
6 Earlier Cystectomy Sig survival benefit for pt1 vs. pt2 BC: pt1: 90% 5-year survival pt2: 50% survival RC for pt1: 30% upstaged, 10-15% N+ Chalasani et al. RC for T1 BC. CUAJ Stein et al. RC in the treatment of BC: long-term results in 1,054 patients. J Clin Oncol, Fritsche et al. Outcomes of patients with T1 BC treated with RC: results from an international cohort. Euro Urology, 2010.
7 Cystectomy even for elderly Retrospective study of > 1000 pts Stratified by < 60, 60s, 70s, > 80yo No mortality difference (1%, 3%, 4%, 0%) No sig difference for those > 70 for IC vs. NB Conclusion: Chronological age not a contraindication for RC Carefully selected older pts can have NB Clark, Stein, Skinner et al. RC in the elderly. Cancer, 2005.
8 Retrospective review of previous multicenter trials including 2400 pts Evaluated risk of recurrence at 3 months Also stratified by intravesical therapy use Brausi et al. European Urology, 2002.
9 Need to improve TURBTs Recurrence varied from 3% - 20% (for single BT) to 7% - 46% (for multiple BTs) Conclusion: Risk of recurrence at 3 months: huge variation depending upon center/surgeon TURBTs are not being performed appropriately Brausi et al. European Urology, 2002.
10 Intravesical BCG First line treatment for CIS and to prevent recurrence after T1 or HG Ta BTs AUA & EUA guidelines Sylvester et al meta-analysis (2005): 68% complete response compared to 50% for chemo At 3.5 years: 50% vs 25% remained disease free (BCG vs chemo) Minimal efficacy after 2 cycles Sylvester et al. BCG vs chemo meta-analysis. Journal of Urology, 2005.
11 Maintenance BCG 3 weekly doses at 3, 6, 12, 18, 24, 30, 36 months Clearly reduces recurrence Lamm: 75% vs 47% RFS (maint vs induc) Hinostu: 93% vs 65% RFS (maint vs induc) Lamm et al. Maintenance therapy: SWOG study. Journal of Urology Hinostu et al. Maintenance therapy clearly prolongs survival. BJU Inter
12 BCG Failures Refractory: persistence of disease Relapse: after >3 or 6 months of diseasefree Early: < 1 year (worse prognosis) Intermediate: 1-2 years Late: > 2 years Intolerant: unable to receive full dose.
13 Management Options for those who refuse RC (or are unfit) CYSTECTOMY Why are they refusing? Have patients discuss with other patients potential lifestyle changes Demonstrate photos of ileal conduits Suggest second-opinion
14 Management Options for those who refuse RC (or are unfit) More BCG BCG/IFN Valstar MMC Docetaxel Gemcitabine
15 More BCG? Failure to achieve complete response to induction: sig risk of progression/death < 10-20% efficacy after 2 nd dose Lerner et al. Failure to achieve complete response... Urologic Oncology, 2009.
16 Prospective, multi-center, randomized study 670 patients 4 arms: BCG naïve pts: BCG vs BCG/IFN & megadose vs RDA vitamins Received Maint End point: + Biopsy or + cytology Nepple KG, et al. Journal of Urology 184: 1915, 2010
17 BCG/IFN with vitamins No difference in RFS at 24 months IFN cohort: increased fevers and consitutional symptoms Conclusion: no benefit to addition of IFN or oncovite Nepple KG, et al. Journal of Urology 184: 1915, 2010
18 Prospective randomized study MMC vs BCG (followed by maintenance) of 261 pts BCG: sig improved RFS vs MMC No difference in progression Crossover treatment: BCG >> MMC Conclusion: BCG superior to MMC for recurrence but not progression or survival Malmstrom et al. Journal of Urology. 161:1124, 1999.
19 Retrospective review of 111 pts who failed BCG Synergo: thermo-chemo with MMC weekly x 6 weeks DFS: 56% at 2 years Improved efficacy in maint cohort (61% vs 39%) Progression: 3% Conclusion: Thermo-chemo may be effective (but needs maint) Not Approved in U.S. Nativ O, et al. Journal of Urology, 182: 1313, 2009.
20 EMDA (Electromotive Drug Administration) Uses an electric field to increase cell permeability Physion (Italy) Studied in MMC and BCG (with improvements over non-emda treated pts) Role in BCG Refractory patients? Di Stasi et al. Sequential BCG and electromotive mitomycin versus BCG alone for HR NMIBC. Lancet Oncology; 7:43, Di Stasi et al. Intravesical electro- motive MMC vs passive transport MMC for HR BC. Journal of Urology,170:777, 2003
21 Intravesical Valrubicin Only FDA-approved therapy for BCGrefractory CIS <10% efficacy at 2 years (and not for T1) Sternberg et al. Valrubicin study group. Journal of Urology, 2000.
22 Retrospective review of two updated Phase III trials 80 BCG-refractory CIS pts received Valrubicin 800mg/weekly 40% had received > 2 BCG courses Dinney et al. Urologic Oncology: of Urology, 31: 1635, 2013.
23 Intravesical Valrubicin Complete Responders: 18% Conclusion: those who are NR should undergo RC Dinney et al. Urologic Oncology: of Urology, 31: 1635, 2013.
24 Retrospective review, 54 patients for salvage docetaxel therapy ( ) Induction: 6 weekly installations (75mg/100ml) Maintenance: monthly x 9 months Barlow et al. Journal of Urology, 189: 834, 2013.
25 Results: Intravesical Docetaxel 60% had complete response after induction 18 continued on maintenance Median time to recurrence: 39 vs. 19 months (maint vs induction only) 1 & 3 year recurrence-free survival: 40% & 25% 30% underwent RC 5-Year DSS/OS: 85% and 70% Conclusions: Consider Intravesical docetaxel for BCG failures Induction + Maint appears to be most appropriate Barlow et al. Journal of Urology, 189: 834, 2013.
26 Retrospective review : 69 patients (37 BCG refractory, 30% recurrent) Instillations: BIW x 6 weeks (2000mg/100ml) Results: 5-yr OS: 58% vs 71% (BCG refrac vs others) 40% achieved complete response 30% underwent RC Conclusion: Consider for those who refuse RC or are unfit Sternberg et al. Journal of Urology, 190: 1686, 2013.
27 Conclusions High-risk NMIBC is deadly Must confirm not actually muscle-invasive ReTURBT Early Cystectomy is always first choice Options limited for those who refuse or are unfit Mixed short-term results with other agents Recommend second opinions
Management of High-Risk Non-Muscle Invasive Bladder Cancer. Seth P. Lerner, MD, FACS
Management of High-Risk Non-Muscle Invasive Bladder Cancer Seth P. Lerner, MD, FACS Professor of Urology, Beth and Dave Swalm Chair in Urologic Oncology, Scott Department of Urology, Baylor College of
Intravesical Therapy for Bladder Cancer
Intravesical Therapy for Bladder Cancer Alexandre R. Zlotta, MD, PhD, FRCSC Professor, Department of Surgery (Urology), University of Toronto Director, Uro-Oncology, Mount Sinai Hospital Director, Uro-Oncology
Non Muscle Invasive Bladder Cancer. Primary and Recurrent TCC 4/10/2010. Two major consequences: Strategies: High-Risk NMI TCC
Intravesical Therapy 2010-When, with What, When to Stop Friday, April 9, 2010 Ralph de VereWhite, MD Director, UC Davis Cancer Center Associate Dean for Cancer Programs Professor, Department of Urolgoy
Non-Muscle Invasive Bladder Cancer BCG Failures: University of Iowa Hospitals and Clinics Experience. Paul Gellhaus Assistant Clinical Professor
Non-Muscle Invasive Bladder Cancer BCG Failures: University of Iowa Hospitals and Clinics Experience Paul Gellhaus Assistant Clinical Professor Iowa??? none Disclosures Caveats Dr. Michael O Donnell
BCG Unresponsive Disease A Roadmap for Drug Development and Integra;on of Novel Therapies
BCG Unresponsive Disease A Roadmap for Drug Development and Integra;on of Novel Therapies Seth P. Lerner, MD, FACS Professor of Urology Beth and Dave Swalm Chair in Urologic Oncology Baylor College of
Risk Adapted Treatment of Non-muscle Invasive Bladder Cancer. Eila C. Skinner, MD
Risk Adapted Treatment of Non-muscle Invasive Bladder Cancer Eila C. Skinner, MD Professor, Department of Urology Stanford University SWIU Winter Meeting January, 2015 Goals Minimize treatment for patients
Novel therapeutic strategies for NMIBC. Peter Black Vancouver Prostate Centre University of British Columbia
Novel therapeutic strategies for NMIBC Peter Black Vancouver Prostate Centre University of British Columbia Financial and Other Disclosures I have the following financial interests or relationships to
BCG Failure or BCG Unresponsive: Defining and Managing Difficult Patients
BCG Failure or BCG Unresponsive: Defining and Managing Difficult Patients Michael S. Cookson, MD, Professor and Chair Department of Urology University of Oklahoma Non-muscle Invasive Bladder Cancer Bladder
BCG Unresponsive NMIBC: What s Available?
BCG Unresponsive NMIBC: What s Available? Michael S. Cookson, MD, MMHC, FACS Professor and Chair Department of Urology University of Oklahoma TwiLer @uromc Professional Practice Gap Gap 1: There is incomplete
Reviewing Immunotherapy for Bladder Carcinoma In Situ
Reviewing Immunotherapy for Bladder Carcinoma In Situ Samir Bidnur Dept of Urologic Sciences, Grand Rounds March 1 st, 2017 Checkpoint Inhibition and Bladder Cancer, an evolving story with immunotherapy
Issues in the Management of High Risk Superficial Bladder Cancer
Issues in the Management of High Risk Superficial Bladder Cancer MICHAEL A.S. JEWETT DIVISION OF UROLOGY, DEPARTMENT OF SURGICAL ONCOLOGY, PRINCESS MARGARET HOSPITAL & THE UNIVERSITY OF TORONTO 1 Carcinoma
Controversies in the management of Non-muscle invasive bladder cancer
Controversies in the management of Non-muscle invasive bladder cancer Sia Daneshmand, MD Associate Professor of Urology (Clinical Scholar) Director of Urologic Oncology Director of Clinical Research Urologic
BC G Unresponsive Non- Muscle Invasive Bladder Cancer
BC G Unresponsive Non- Muscle Invasive Bladder Cancer Seth P. Lerner, MD, FACS Professor of Urology Beth and Dave Swalm Chair in Urologic Oncology ScoA Department of Urology Baylor College of Medicine,
Critical Evaluation of Early Post-operative Single Instillation Therapy in NMIBC
Critical Evaluation of Early Post-operative Single Instillation Therapy in NMIBC Levent N. Türkeri MD, PhD Professor of Urology Acıbadem University Faculty of Medicine Istanbul Conflict of Interest No
Management of High Grade, T1 Bladder Cancer Douglas S. Scherr, M.D.
Management of High Grade, T1 Bladder Cancer Douglas S. Scherr, M.D. Assistant Professor of Urology Clinical Director, Urologic Oncology Weill Medical College-Cornell University Estimated new cancer cases.
Intravesical gemcitabine in combination with mitomycin C as salvage treatment in recurrent non-muscle-invasive bladder cancer
Intravesical gemcitabine in combination with mitomycin C as salvage treatment in recurrent non-muscle-invasive bladder cancer Patrick A. Cockerill, John J. Knoedler, Igor Frank, Robert Tarrell and Robert
RITE Thermochemotherapy in the treatment of BCG refractory NMIBC
RITE Thermochemotherapy in the treatment of BCG refractory NMIBC Ben Ayres Consultant Urological Surgeon St George s Hospital London 1 Financial and Other Disclosures Off-label use of drugs, devices, or
Optimising the management of non-muscle invasive bladder cancer from diagnosis to cure. Dr Richard Savdie Uro-Oncology Fellow BSc MBBS FRACS
Optimising the management of non-muscle invasive bladder cancer from diagnosis to cure Dr Richard Savdie Uro-Oncology Fellow BSc MBBS FRACS Objectives 1. Explore best practice diagnostic techniques 2.
Treatment of Invasive Bladder Cancer in the Elderly and Frail Pa9ent
Treatment of Invasive Bladder Cancer in the Elderly and Frail Pa9ent Jehonathan H Pinthus MD, Ph.D, FRCSC Associate Professor Department of Surgery/Urology McMaster University Life expectancy Current age
Intravesical Gemcitabine for High Risk, Nonmuscle Invasive Bladder Cancer after Bacillus Calmette-Guerin Treatment Failure
Intravesical Gemcitabine for High Risk, Nonmuscle Invasive Bladder Cancer after Bacillus Calmette-Guerin Treatment Failure Itay A. Sternberg, Guido Dalbagni,* Ling Y. Chen, Sherri M. Donat, Bernard H.
Sequential Intravesical Gemcitabine and Docetaxel for the Salvage Treatment of Non-Muscle Invasive Bladder Cancer
Bladder Cancer 1 (2015) 65 72 DOI 10.3233/BLC-150008 IOS Press Research Report 65 Sequential Intravesical Gemcitabine and Docetaxel for the Salvage Treatment of Non-Muscle Invasive Bladder Cancer Ryan
CUA guidelines on the management of non-muscle invasive bladder cancer
Original cua guidelines research CUA guidelines on the management of non-muscle invasive bladder cancer Wassim Kassouf, MD, CM, FRCSC; * Samer L. Traboulsi, MD; * Girish S. Kulkarni, MD, FRCSC; Rodney
UC San Francisco UC San Francisco Previously Published Works
UC San Francisco UC San Francisco Previously Published Works Title Multi-institutional analysis of sequential intravesical gemcitabine and mitomycin C chemotherapy for non-muscle invasive bladder cancer
Contemporary management of high-grade T1 bladder cancer Arnulf Stenzl
Contemporary management of high-grade T1 bladder cancer Arnulf Stenzl Dep. of Urology, Eberhard-Karls University, Tuebingen, Germany Treatment options in HG T1 BCa TUR-BT Primary and second resection (T0-status)
September 10, Dear Dr. Clark,
September 10, 2015 Peter E. Clark, MD Chair, NCCN Bladder Cancer Guidelines (Version 2.2015) Associate Professor of Urologic Surgery Vanderbilt Ingram Cancer Center Nashville, TN 37232 Dear Dr. Clark,
14th Meeting of the EAU Section of Oncological Urology (ESOU)
Is Bacillus Calmette-Guerin (BCG) still the best adjuvant treatment after Trans Urethral Resection (TUR) for Ta-T1 high grade (G3) bladder cancer M. Brausi, Modena (IT) Introduction Bacillus Calmette-Guerin
NATIONAL INSTITUTE FOR HEALTH AND CARE EXCELLENCE
NATIONAL INSTITUTE FOR HEALTH AND CARE EXCELLENCE INTERVENTIONAL PROCEDURES PROGRAMME Interventional procedure overview of intravesical microwave hyperthermia with intravesical chemotherapy for superficial
Research Report. Keywords: Bladder Cancer, BCG failure, virtual clinical trial, mitomycin C
Bladder Cancer 1 (2015) 143 150 DOI 10.3233/BLC-150020 IOS Press Research Report 143 Novel Simulation Model of Non-Muscle Invasive Bladder Cancer: A Platform for a Virtual Randomized Trial of Conservative
NATIONAL INSTITUTE FOR HEALTH AND CLINICAL EXCELLENCE
NATIONAL INSTITUTE FOR HEALTH AND CLINICAL EXCELLENCE INTERVENTIONAL PROCEDURES PROGRAMME Interventional procedure overview of electrically-stimulated intravesical chemotherapy for superficial bladder
T1HG Bladder Cancer What is the Best Therapy?
T1HG Bladder Cancer What is the Best Therapy? Ashish M. Kamat, MD, MBBS, FACS Professor of Urology Director, Urologic Oncology Fellowship Guidelines for T1HG Bladder Cancer AUA Recommendation: BCG induction
CUA guidelines on the management of non-muscle invasive bladder cancer
Original cua guidelines research CUA guidelines on the management of non-muscle invasive bladder cancer Wassim Kassouf, MD, CM, FRCSC; * Samer L. Traboulsi, MD; * Girish S. Kulkarni, MD, FRCSC; Rodney
Management of Difficult Cases of Non-Muscle Invasive Bladder Cancer
Management of Difficult Cases of Non-Muscle Invasive Bladder Cancer 1 Bladder Cancer Recurrence is common Progression is uncommon Progression is more important than recurrence There are indicators of recurrence
Optimal sequencing in treatment muscle invasive bladder cancer : oncologists. Phichai Chansriwong, MD Ramathibodi Hospital, Mahidol University
Optimal sequencing in treatment muscle invasive bladder cancer : oncologists Phichai Chansriwong, MD Ramathibodi Hospital, Mahidol University Slide 2 Presented By Andrea Apolo at 2018 Genitourinary Cancers
Panel: A Case-based Approach to the Management of Bladder Cancer
Panel: A Case-based Approach to the Management of Bladder Cancer ~ Moderator: Robert Donohue, MD Panel: David C. Beyer, MD E. David Crawford, MD Donald L. Lamm, MD Paul D. Maroni, MD TCC Cases Robert E.
Neoadjuvant vs. Adjuvant Chemotherapy for Muscle-Invasive Bladder Cancer
Neoadjuvant vs. Adjuvant Chemotherapy for Muscle-Invasive Bladder Cancer Andrew J. Stephenson, MD, FRCSC, FACS Director, Urologic Oncology Associate Professor of Surgery Glickman Urological and Kidney
Management of Superficial Bladder Cancer Douglas S. Scherr, M.D.
Management of Superficial Bladder Cancer Douglas S. Scherr, M.D. Assistant Professor of Urology Clinical Director, Urologic Oncology Weill Medical College-Cornell University Estimated new cancer cases.
A Personal History NIH CWRU U of TN U of Miami Animal Model for Bladder Cancer Carcinogen induced FANFT Three Models Primary tumors individual tumors, simulates clinical scenario of locally advanced cancer
Bladder Cancer Guidelines
Bladder Cancer Guidelines Agreed by Urology CSG: October 2011 Review Date: September 2013 Bladder Cancer 1. Referral Guidelines The following patients should be considered as potentially having bladder
Urinary Bladder Cancer
Fellow GU Lecture Series, 2018 Urinary Bladder Cancer Asit Paul, MD, PhD 01/31/2018 Overview Non-muscle invasive bladder cancer Muscle invasive bladder cancer Bladder sparing chemo-radiation therapy T4b
Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of bladder carcinoma
Kamat et al. Journal for ImmunoTherapy of Cancer (2017) 5:68 DOI 10.1186/s40425-017-0271-0 POSITION ARTICLE AND GUIDELINES Society for Immunotherapy of Cancer consensus statement on immunotherapy for the
Bladder Cancer Canada November 21st, Bladder Cancer 2018: A brighter light at the end of the cystoscope
Bladder Cancer Canada November 21st, 2018 Bladder Cancer 2018: A brighter light at the end of the cystoscope Chris Morash MD FRCSC Associate Professor, University of Ottawa Head, Urological Oncology Bladder
Mixed low and high grade non muscle invasive bladder cancer: a histological subtype with favorable outcome
DOI 10.1007/s00345-014-1383-5 Original Article Mixed low and high grade non muscle invasive bladder cancer: a histological subtype with favorable outcome Tina Schubert Matthew R. Danzig Srinath Kotamarti
/05/ /0 Vol. 174, 86 92, July 2005 THE JOURNAL OF UROLOGY. Printed in U.S.A. Copyright 2005 by AMERICAN UROLOGICAL ASSOCIATION
0022-5347/05/1741-0086/0 Vol. 174, 86 92, July 2005 THE JOURNAL OF UROLOGY Printed in U.S.A. Copyright 2005 by AMERICAN UROLOGICAL ASSOCIATION DOI: 10.1097/01.ju.0000162059.64886.1c BACILLUS CALMETTE-GUERIN
Early radical cystectomy in NMIBC Marko Babjuk
Early radical cystectomy in NMIBC Marko Babjuk Dept. of Urology, 2nd Faculty of Medicine, Hospital Motol, Praha, Czech Republic We Are The European Association of Urology We Are Urologists, residents,
Alicia K. Morgans, MD Assistant Professor of Medicine Division of Hematology/Oncology Vanderbilt University Medical Center January 24, 2015
Alicia K. Morgans, MD Assistant Professor of Medicine Division of Hematology/Oncology Vanderbilt University Medical Center January 24, 2015 Overview Background Perioperative chemotherapy in MIBC Neoadjuvant
NMIBC. Piotr Jarzemski. Department of Urology Jan Biziel University Hospital Bydgoszcz, Poland
NMIBC Piotr Jarzemski Department of Urology Jan Biziel University Hospital Bydgoszcz, Poland 71 year old male patient was admitted to the Department of Urology First TURBT - 2 months prior to the hospitalisation.
When to Integrate Surgery for Metatstatic Urothelial Cancers
When to Integrate Surgery for Metatstatic Urothelial Cancers Wade J. Sexton, M.D. Senior Member and Professor Department of Genitourinary Oncology Moffitt Cancer Center Case Presentation #1 67 yo male
Bacille-Calmette-Guerin non-responders: how to manage
Review Article Bacille-Calmette-Guerin non-responders: how to manage Friedrich-Carl von Rundstedt 1,2, Seth P. Lerner 1 1 Scott of Department of Urology, Translational Biology and Molecular Medicine, Dan
RITE Thermo-chemotherapy for NON MUSCLE INVASIVE BLADDER CANCER (NMIBC) Ulrich K.Fr. Witzsch
Thermo-chemotherapy for NON MUSCLE INVASIVE BLADDER CANCER (NMIBC) Ulrich K.Fr. Witzsch Klinik für Urologie und Kinderurologie, Chefarzt Prof. Dr. med Dr. hc E. Becht Krankenhaus Nordwest, Stiftung Hospital
Bladder Preservation Strategies for Muscle Invasive Bladder Cancer
Bladder Preservation Strategies for Muscle Invasive Bladder Cancer Jeff M. Michalski, MD, MBA, FACR, FASTRO The Carlos A. Perez Distinguished Professor of Radiation Oncology Department of Radiation Oncology
THE USE OF HALF DOSE BCG FOR INTRAVESICAL IMMUNOTHERAPY IN NON MUSCLE INVASIVE BLADDER CANCER
THE USE OF HALF DOSE BCG FOR INTRAVESICAL IMMUNOTHERAPY IN NON MUSCLE INVASIVE BLADDER CANCER Mihály Zoltán Attila 1, Rusu Cristian Bogdan 2, Mihály Orsolya Maria 3, Bolboacă Sorana Daniela 4, Bungărdean
The Role of Bacillus Calmette-Guérin in the Treatment of Non Muscle-Invasive Bladder Cancer
EUROPEAN UROLOGY 57 (2010) 410 429 available at www.sciencedirect.com journal homepage: www.europeanurology.com Collaborative Review Bladder Cancer The Role of Bacillus Calmette-Guérin in the Treatment
Original Article APMC-276
Original Article APMC-276 The Clinical Value of Immediate Second Transurethral Resection in Patients with High Grade Non-Muscle Inasive Bladder Cancer (HG-NMIBC) Syed Saleem Abbas Jafri, Zafar Iqbal Khan
MANAGING PATIENTS WITH NON-MUSCLE INVASIVE BLADDER CANCER: OLD DISEASE, NEW IDEAS
MANAGING PATIENTS WITH NON-MUSCLE INVASIVE BLADDER CANCER: OLD DISEASE, NEW IDEAS This symposium took place on 12 th March 2016 as part of the European Association of Urology Congress 2016 in Munich, Germany
Maintenance Therapy with Intravesical Bacillus Calmette Guérin in Patients with Intermediate- or High-risk Non-muscle-invasive
Jpn J Clin Oncol 2013;43(3)305 313 doi:10.1093/jjco/hys225 Advance Access Publication 9 January 2013 Maintenance Therapy with Intravesical Bacillus Calmette Guérin in Patients with Intermediate- or High-risk
Contents of Online Supporting Information. etable 1. Study characteristics for trials of intravesical therapy vs. TURBT alone
Contents of Online Supporting Information etable 1. Study characteristics for trials of intravesical therapy vs. TURBT alone etable 2. Study characteristics of head to head trials of intravesical therapy
Non Muscle-Invasive Bladder Cancer: Intravesical Treatments Beyond Bacille Calmette-Guerin
Non Muscle-Invasive Bladder Cancer: Intravesical Treatments Beyond Bacille Calmette-Guerin Vignesh T. Packiam, MD; Scott C. Johnson, MD; and Gary D. Steinberg, MD An unmet need exists for patients with
ROBOTIC VS OPEN RADICAL CYSTECTOMY
ROBOTIC VS OPEN RADICAL CYSTECTOMY A REVIEW Colin Lundeen December 14, 2016 Objectives Review the history of radical cystectomy Critically analyze recent RCTs comparing open radical cystectomy (ORC) to
Case by Case: Critical Issues in Superficial Bladder Cancer Management 5/24/05 13:46 1
Case by Case: Critical Issues in Superficial Bladder Cancer Management 5/24/05 13:46 1 Case Study 1 A 22-year-old man with a history of gross total painless hematuria: two times in two months, both after
SUPERFICIAL BLADDER CANCER MANAGEMENT
A CME Webcast/TELECONFERENCE Case by Case: CRITICAL ISSUES IN SUPERFICIAL BLADDER CANCER MANAGEMENT An Interactive Case Format with Instant Audience Polling APRIL-MAY 2005 CME Program Slide Book Sponsored
Options for first-line cisplatin-eligible patients
The Past Options for first-line cisplatin-eligible patients Metastatic urothelial cancer Cisplatin-eligible Gemcitabine/ cisplatin MVAC or high-dose intensity MVAC Paclitaxel/ cisplatin/ gemcitabine Bellmunt
TARGETING CANCER WITH POWER AND PRECISION
TARGETING CANCER WITH POWER AND PRECISION T h o m a s C a n n e l l, D. V. M., P r e s i d e n t a n d C E O A u g u s t 9, 2 0 1 8 NASDAQ: SESN FORWARD-LOOKING STATEMENTS This presentation contains forward-looking
Mark Kowalski, Jacinthe Guindon, Louise Brazas, Celine Moore, Joycelyn Entwistle, Jeannick Cizeau, Michael A. S. Jewett* and Glen C.
A Phase II Study of Oportuzumab Monatox: An Immunotoxin Therapy for Patients with Noninvasive Urothelial Carcinoma In Situ Previously Treated with Bacillus Calmette-Guérin Mark Kowalski, Jacinthe Guindon,
Bladder Preservation for muscle invasive disease. Nicholas
Bladder Preservation for muscle invasive disease Nicholas James @Prof_Nick_James 1 Overview Evidence base for bladder preservation as alternative to surgery Chemoradiotherapy compared to radiotherapy alone
The Effects of Intravesical Chemoimmunotherapy with Gemcitabine and Bacillus Calmette Guérin in Superficial Bladder Cancer: a Preliminary Study
The Journal of International Medical Research 2009; 37: 1823 1830 The Effects of Intravesical Chemoimmunotherapy with Gemcitabine and Bacillus Calmette Guérin in Superficial Bladder Cancer: a Preliminary
CHEMO-RADIOTHERAPY FOR BLADDER CANCER. Dr Darren Mitchell Consultant Clinical Oncologist Northern Ireland Cancer Centre
CHEMO-RADIOTHERAPY FOR BLADDER CANCER Dr Darren Mitchell Consultant Clinical Oncologist Northern Ireland Cancer Centre AIMS Muscle invasive disease Current Gold-Standard Rationale behind Chemo-Radiotherapy
Diagnosis & Treatment of Non- Muscle Invasive Bladder Cancer: AUA/SUO Guidelines
Diagnosis & Treatment of Non- Muscle Invasive Bladder Cancer: AUA/SUO Guidelines Sam S. Chang, MD, MBA Patricia & Rodes Hart Chair Professor of Urologic Surgery & Oncology Vanderbilt University Medical
Objectives. Results. Patients and Methods. Conclusions. associated percentages were used to analyse treatment variables.
Current clinical practice gaps in the treatment of intermediate- and high-risk non-muscleinvasive bladder cancer (NMIBC) with emphasis on the use of bacillus Calmette- Guérin (BCG): results of an international
Effective Health Care Program
Comparative Effectiveness Review Number 153 Effective Health Care Program Emerging Approaches to Diagnosis and Treatment of Non Muscle-Invasive Bladder Cancer Executive Summary Background Bladder cancer
Prostate cancer Management of metastatic castration sensitive cancer
18 th Annual Advances in Oncology - 2017 Prostate cancer Management of metastatic castration sensitive cancer Urothelial carcinoma Non-muscle invasive urothelial carcinoma Updates in metastatic urothelial
Collection of Recorded Radiotherapy Seminars
IAEA Human Health Campus Collection of Recorded Radiotherapy Seminars http://humanhealth.iaea.org Conservative Treatment of Invasive Bladder Cancer Luis Souhami, MD Professor Department of Radiation Oncology
The Rationale for Immunotherapy as an Adjuvant Treatment for Locally Advanced BC
The Rationale for Immunotherapy as an Adjuvant Treatment for Locally Advanced BC Seth P. Lerner, MD, FACS Professor, Scott Department of Urology Beth and Dave Swalm Chair in Urologic Oncology Baylor College
Intravesical Gemcitabine for Treatment of Superficial Bladder Cancer not Responding to Bacillus Calmette-Guérin Vaccine
African Journal of Urology 1110-5704 Vol. 16, No. 4, 2010 110-116 Original article Intravesical Gemcitabine for Treatment of Superficial Bladder Cancer not Responding to Bacillus Calmette-Guérin Vaccine
Intravesical radiofrequency-induced hyperthermia combined with chemotherapy for non-muscleinvasive
International Journal of Hyperthermia ISSN: 0265-6736 (Print) 1464-5157 (Online) Journal homepage: http://www.tandfonline.com/loi/ihyt20 Intravesical radiofrequency-induced hyperthermia combined with chemotherapy
Chemotherapy and Bladder Cancer. Blayne Welk UBC Urology Grand Rounds June 4, 2008
Chemotherapy and Bladder Cancer Blayne Welk UBC Urology Grand Rounds June 4, 2008 Outline Review of Incidence and Impact of bladder cancer Neoadjuvant chemotherapy Adjuvant chemotherapy Bladder preservation
EUROPEAN UROLOGY 56 (2009)
EUROPEAN UROLOGY 56 (2009) 247 256 available at www.sciencedirect.com journal homepage: www.europeanurology.com Platinum Priority Bladder Cancer Editorial by Guido Dalbagni on pp. 257 258 of this issue
Updateof NMIBC management. Critical
Updateof NMIBC management. Critical analysisof EAU Guidelines Eduardo Solsona Service of Urology. Instituto Valenciano de Oncología Valencia. Spain solsona@pulso.com Disclosures Adisory Boards -Sanofi
Should We Screen for Bladder Cancer in a High Risk Population: A Cost per Life-Year Saved Analysis?
Should We Screen for Bladder Cancer in a High Risk Population: A Cost per Life-Year Saved Analysis? Yair Lotan, Robert S. Svatek, Arthur I. Sagalowsky Should We Screen? Prevalence 5 th most common cancer
Who is the Ideal Candidate for PEG Intron?
Who is the Ideal Candidate for PEG Intron? Sanjiv S. Agarwala, MD Chief, Oncology & Hematology St. Luke s Cancer Center Professor, Temple University School of Medicine Philadelphia, PA, USA Overview Introduction
european urology 52 (2007)
european urology 52 (2007) 1123 1130 available at www.sciencedirect.com journal homepage: www.europeanurology.com Urothelial Cancer Long-Term Intravesical Adjuvant Chemotherapy Further Reduces Recurrence
Effects of P-MAPA Immunomodulator on Toll-like Receptors and Angiogenesis: Potential Therapeutic Strategies For Non-Muscle Invasive Bladder Cancer
UNIVERSITY OF CAMPINAS (UNICAMP) INSTITUTE OF BIOLOGY DEPARTAMENT OF STRUCTURAL AND FUNCTIONAL BIOLOGY Effects of P-MAPA Immunomodulator on Toll-like Receptors and Angiogenesis: Potential Therapeutic Strategies
Abstract. Abstract. Abstract. Abstract. Abstract 11/12/2013. Contemporary Intravesical Therapy for Non-Muscle Invasive Bladder Cancer
Abstract Contemporary Intravesical Therapy for Non-Muscle Invasive Bladder Cancer Adele M. Caruso, MSN, CRNP Adult Nurse Practitioner Clinical Practices of the University of Pennsylvania Urinary Bladder
Clinical Practice Recommendations for the Management of Non Muscle Invasive Bladder Cancer
european urology supplements 7 (2008) 651 666 available at www.sciencedirect.com journal homepage: www.europeanurology.com Clinical Practice Recommendations for the Management of Non Muscle Invasive Bladder
Improving Patient Outcomes: Optimal BCG Treatment Regimen to Prevent Progression in Superficial Bladder Cancer
european urology supplements 5 (2006) 654 659 available at www.sciencedirect.com journal homepage: www.europeanurology.com Review Improving Patient Outcomes: Optimal BCG Treatment Regimen to Prevent Progression
models; Kaplan meier curves were also extrapolated for each cohort to compare disease specific and overall survival patterns.
; 21 Urological Oncology MUSCULARIS PROPRIA AND UPSTAGING OF ct1 BLADDER CANCER BADALATO ET AL. BJUI Does the presence of muscularis propria on transurethral resection of bladder tumour specimens affect
Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Bladder irrigation after transurethral resection of superficial bladder cancer: a systematic review of the literature Amr Mahran, MD, 1,2 Laura Bukavina, MD, 1,2 Kirtishri Mishra, MD, 1,2 Christina Buzzy,
Adjuvant chemotherapy in older breast cancer patients: how to decide?
Adjuvant chemotherapy in older breast cancer patients: how to decide? H. Wildiers University Hospitals Leuven Belgium Wildiers H, Kunkler I, Lancet Oncol 2007 Biganzoli L, Wildiers H, Lancet Oncol. 2012
Open clinical uro-oncology trials in Canada
CLINICAL TRIALS Open clinical uro-oncology trials in Canada Eric Winquist, MD, Mary J. Mackenzie, MD, George Rodrigues, MD London Health Sciences Centre, London, Ontario, Canada ADRENOCORTICAL MALIGNANCIES
Neodjuvant chemotherapy
Neodjuvant chemotherapy Dr Robert Huddart Senior Lecturer and Honorary Consultant in Clinical Oncology Royal Marsden Hospital and Institute of Cancer Research Why consider neo-adjuvant chemotherapy? Loco-regional
Some Seminal Studies. Chemotherapy Alone is Inadequate. Bladder Cancer Role of Radiation in Bladder Sparing. Primary Radiation for Bladder Cancer
Bladder Cancer Role of Radiation in Bladder Sparing David C. Beyer M.D., FACR, FACRO, FASTRO Arizona Oncology Services Phoenix, Arizona Primary Radiation for Bladder Cancer No modern surgery / XRT randomized
Predicting Response to Intravesical Immunotherapy (BCG) in NMIBC
Predicting Response to Intravesical Immunotherapy (BCG) in NMIBC Ashish M. Kamat, MD, MBBS, FACS Professor of Urologic Oncology Wayne B. Duddlesten Professor of Cancer Research President, International
GUIDELINES ON NON-MUSCLE- INVASIVE BLADDER CANCER
GUIDELINES ON NON-MUSCLE- INVASIVE BLADDER CANCER (Limited text update December 21) M. Babjuk, W. Oosterlinck, R. Sylvester, E. Kaasinen, A. Böhle, J. Palou, M. Rouprêt Eur Urol 211 Apr;59(4):584-94 Introduction
Emerging Approaches for (Neo)Adjuvant Therapy for ER+ Breast Cancer
Emerging Approaches for (Neo)Adjuvant Therapy for E+ Breast Cancer Cynthia X. Ma, M.D., Ph.D. Associate Professor of Medicine Washington University in St. Louis Outline Current status of adjuvant endocrine
1. Introduction. 2. Methods. high-risk NMIBC in men with and without a prior history of RT for PC.
ISRN Urology Volume 2013, Article ID 405064, 5 pages http://dx.doi.org/10.1155/2013/405064 Research Article Radical Cystectomy after BCG Immunotherapy for High-Risk Nonmuscle-Invasive Bladder Cancer in
Point-Counterpoint: Radiation & Bladder Cancer
Radiation Plays a Major Role in Certain Stages of Bladder Cancer ~ David C. Beyer, MD Radiation Therapy; no role in management of bladder cancer Robert E. Donohue M.D. Denver VAMC University of Colorado
Influence of an electric i field on the efficacy of Mitomycin C treatment of bladder cancer. DaBlaCa study 3
Influence of an electric i field on the efficacy of Mitomycin C treatment of bladder cancer. DaBlaCa study 3 Juan Luis VÄsquez PhD Project description (Academically approved for ernrollment at The University
Guidelines for the Management of Bladder Cancer West Midlands Expert Advisory Group for Urological Cancer
Guidelines for the Management of Bladder Cancer West Midlands Expert Advisory Group for Urological Cancer West Midlands Clinical Networks and Clinical Senate Coversheet for Network Expert Advisory Group
Oncotype DX testing in node-positive disease
Should gene array assays be routinely used in node positive disease? Yes Christy A. Russell, MD University of Southern California Oncotype DX testing in node-positive disease 1 Validity of the Oncotype
INTRAVESICAL ELECTROMOTIVE MITOMYCIN C VERSUS PASSIVE TRANSPORT MITOMYCIN C FOR HIGH RISK SUPERFICIAL BLADDER CANCER: A PROSPECTIVE RANDOMIZED STUDY
0022-5347/03/1703-0777/0 Vol. 170, 777 782, September 2003 THE JOURNAL OF UROLOGY Printed in U.S.A. Copyright 2003 by AMERICAN UROLOGICAL ASSOCIATION DOI: 10.1097/01.ju.0000080568.91703.18 INTRAVESICAL
Disclosures. The Importance of Pathology? Pathologic, Morphologic and Clinical Features. Pathologic Reproducibility
The Importance of Pathology? Seth P. Lerner, MD, FACS Beth and Dave Swalm Chair in Urologic Oncology Scott Department of Urology Baylor College of Medicine Support for research Disclosures Photocure, Imalux,