Adjuvant Therapy in Locally Advanced Head and Neck Cancer. Ezra EW Cohen University of Chicago. Financial Support
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1 Adjuvant Therapy in Locally Advanced Head and Neck Cancer Ezra EW Cohen University of Chicago Financial Support This program is made possible by an educational grant from Eli Lilly Oncology, who had no input in its content. 1
2 Conflicts of Interest Dr. Cohen has received honoraria from Bristol-Myers Squibb and Sanofi- Aventis. He has consulted for Amgen. Heterogeneity Primary sites Lip Oral cavity Oropharynx Hypopharynx Larynx Paranasal sinuses Nasopharynx Salivary glands 95% are squamous cell carcinomas Anatomic Sites and Subsides of the Head and Neck 2
3 2008, US: new cases 7600 deaths Worldwide: new cases Incidence 6th leading cause of death M:F = 2:1 Survival Overall 50% long-term survival Recurrence Second malignancies Co-morbidities 3
4 Staging Stage at Diagnosis Stage IVc Stage I, II Stage III, IVa, IVb TREATED WITH CURATIVE INTENT Risk Factors Age (majority of patients >50 years old) Tobacco Alcohol Viral Epstein-Barr virus (NPC) HPV (oropharynx) Hereditary (rare): Family history increases risk (3.5X) Rare genetic syndromes, e.g. Fanconi s Anemia 4
5 Cure is Paramount, QoL is Important List, M. A. et al. J Clin Oncol; 18: Post-Op CRT 5
6 EORTC and RTOG 9501 Phase III Trials: Adjuvant RT ± Concomitant Cisplatin Resectable SCC Oral cavity, oropharynx, hypopharynx, larynx Stage IIIIV (EORTC), high risk (RTOG) Previously untreated N=334 (EORTC) N=459 (RTOG) Surgery R A N D O M I Z E Adjuvant CRT RT Cisplatin (100 mgm 2, d1,22,43) RT Alone EORTC: 66 Gy over 6.5 wks RTOG: Gy over wks Bernier. N Engl J Med. 2004;350:1945; Cooper. N Engl J Med. 2004;350:1937. Post-Op CRT EORTC patients Primary endpoint: PFS Positive margins 28% > 2 LN 54% ECS 57% RTOG patients Primary endpoint: LRC Positive margins 18% > 2 LN or ECS 82% 6
7 Post-Op CRT Phase 3 Studies * p<0.05 EORTC RTOG (Cooper, (Bernier, 2004) 2004) CRT RT CRT RT Incidence of Locoregional Failure 18% 31%* 16% 29%* Incidence of Metastases 21% 25% 20% 23% Grade >3 Adverse Effects 41% 21%* 77% 34%* 5-Year Estimated PFS 47% 36%* NR 5-Year Estimated OS 53% 40%* HR=0.84 ( ), P= Year Locoregional 82% 72%* Control Rate NR HR=0.78 (0.61- DFS 0.99)* EORTC and RTOG 9501 OS (EORTC) OS (RTOG) P=0.02 P=0.19 Months After Randomization Pooled Analysis: The most significant prognostic factors for poor outcome were ECS and positive margins Subjects with 2 or more lymph nodes without ECS, did not seem to benefit 7
8 Targeting EGFR in SCCHN EGFR in almost universally expressed in SCCHN Expression has been linked to poor prognosis Inhibition of EGFR by monoclonal antibodies or small molecules: effective preclinically demonstrate reproducible clinical activity Phase II Randomized Trial of Postoperative Chemoradiotherapy Plus Cetuximab for High-Risk Squamous Cell Carcinoma of the Head and Neck (RTOG 0234) M. S. Kies 1, J. Harris 2, M. Z. Rotman 3, J. N. Myers 1, R. L. Foote 4, M. Machtay 5, D. Khuntia 6, W. L. Straube 7, K. K. Ang 1, and P. M. Harari 8 1 UT MD Anderson Cancer Center, Houston, TX, 2 American College of Radiology-Radiation Radiation Therapy Oncology Group, Philadelphia, PA, 3 SUNY Downstate Medical Center, Brooklyn, NY, 4 Mayo Clinic, Rochester, MN, 5 Jefferson Medical College, Philadelphia, PA, 6 University of Wisconsin, Madison, WI, 7 Washington University, St. Louis, MO, 8 University of Wisconsin School of Medicine, Madison, WI Supported by RTOG U10 CA21661, CCOP U10 CA37422 and ATC U24 CA Supported by RTOG U10 CA21661, CCOP U10 CA37422 and ATC U24 CA grants from NCI. Additional support was provided by Sanofi-Aventis and Bristol- Myers Squibb
9 Objectives Primary: A randomized phase II study of chemoradiotherapy with cetuximab, in high-risk postoperative head and neck patients, to evaluate disease-free survival relative to chemoradiation of RTOG Treatment Schema S T R A T I F Y Zubrod Score Risk Category a 1. Positive margins 2. High risk ( 2 positive nodes or extranodal capsular spread) R A N D O M I Z E Arm 1 Week 1: Cetuximab 400mgm2 Weeks 2-7: 60 Gy (2 Gyday) - CDDP 30mgm2 + cetuximab 250 mgm2 Arm 2 Week 1: Cetuximab 400 mgm2 Weeks 2-7: 60 Gy (2 Gyday) - Docetaxel 15 mgm2 + cetuximab 250 mgm2 Gross total resection must be completed within 7 weeks of randomization. a If both risk factors are present, patient will be stratified as positive margins
10 RTOG 0234 Eligibility Stage III IV SCCHN sp gross total surgical resection Must have positive resection margins and or 2 nodal metastases and or ECS Performance Status Adverse Events Grades 3 5 (%) RT CDDP RT Doc cetuximab cetuximab (n = 97) (n = 106) Hypersensitivity Bone Marrow Infection Metabolic Mucositis Rash Respiratory Overall (%)
11 Disease-Free Survival RT CDDPcetuximab vs RTOG Disease-Free Survival (%) RT+CDDP+Cet HR (95% CI) 0.85 (0.60, 1.21) 1-sided log-rank p= RT+CDDP Patients at Risk RTOG 0234 RTOG Years after Registration Disease-Free Survival RT Doccetuximab vs RTOG Disease-Free Survival (%) RT+Doc+Cet HR (95% CI) 0.72 (0.50, 1.02) 1-sided log-rank p= RT+CDDP Patients at Risk RTOG 0234 RTOG Years after Registration
12 Erlotinib Prevention of Oral Cancer (EPOC) IEN alone Proportion of cases not developing SOM (%) IEN plus cancer history MDACC (Papadimitrakopoulou, Lippman, Mao et al) U Chicago (Cohen et al) MSKCC (Boyle et al) Emory (Shin et al) P01 CA
13 Randomized Phase II Trial of Everolimus Versus Placebo as Adjuvant Therapy in Patients with Locally Advanced Squamous Cell Cancer of the Head and Neck (SCCHN) Study Design Screening Randomization (n=160) Treatment Enrollment -assess eligibility -sign ICF -obtain tissue Curative Intent Therapy 8-16 Weeks RANDOMIZE Everolimus 10mg OD Primary Endpoint: 2-year PFS Placebo Confirm NED Double-blinded Stratification: Treatment Center Stage (IVa vs. IVb) 13
14 Conclusions High risk post-operative patients benefit from the addition of chemotherapy to radiotherapy The decision to undergo surgery first should be undertaken with care and does not represent the standard of care for most head and neck cancer patients. New therapies are being introduced in an effort to improve outcomes further. We thank Eli Lilly for their support of this program. 14
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