CURRICULUM VITAE Associate Professor College of Basic Medicine Nanjing University of Chinese Medicine, Nanjing, China

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1 CURRICULUM VITAE XU ZHANG Graduate School Nanjing University of Chinese Medicine Nanjing, China Tel: Academic Appointments 2008 Present Professor International Education College, Graduate School Associate Professor College of Basic Medicine Associate Professor College of Chinese Medicine Macau University of Science and Technology, Macau, China Interpreter Study Center of Energy Therapy, Milan, Italy Administrative Appointments 2013 Present Dean Graduate School Associate Dean International Education College Education and Training Visiting scholar, Molecular Pharmacology School of Medicine, Emory University, USA Postdoctoral Fellow, Chinese Materia Medica Ph.D. Clinic Basis of Chinese Medicine M.Sc. Cell Biology Nanjing Normal University, Nanjing, China B.Sc. Biology Inner Mongolia Normal University, Hohhot, China 1

2 2007, 12 Genome Zhejiang University, China 2007, 10 Medical Genome and Clinical Application China Medical Society 2007, 11 Senior Seminar on Modern Medical Development Jiangsu province 2007, 7-8 Bioinformatics National Education Bureau, National Nature Scientific Foundation Tsinghua University, China 2003, 5 Microarray Technique United Gene, Shanghai, China 2002, 12 Laser Confocal Microscope Technique Jinan University, Guangzhou, China Honors 2013 Award for Achievements in Science and Technology by China Association of Chinese Medicine 2011 The outstanding contributor of science and technology Nanjing University of Chinese Medicine 2009 Excellent Talent in Six Fields of Jiangsu Province 2007 Jiangsu Provincial Young and Middle Aged S&T Leading Expert 333 Talent Training Project 2007 Member of Innovation Team Qinglan Project of Jiangsu College and University 2006 A Resource Speaker Herbal Medicines Conference 2006, Malaysia 2006 Jiangsu Provincial Talents in Six Fields 2005 Trainer of Young and Middle Aged Academic Leading Expert Qinglan Project of Jiangsu College and University 2005 Jiangsu Excellent PhD. Dissertation 2005 Nanjing Award for Achievements in Science and Technology 2005 Excellence in Mentorship Award 2004 APASL 2004-Travel Bursary Asian Pacific Association for the Study of the Liver 2004 Excellence Youth Award 2003 Nanjing Award for Achievements in Science and Technology 2001 Jiangsu Provincial Award for Achievements in Science and Technology Jiangsu Provincial Government 1999 Excellent Course Prize Jiangsu Provincial Government 1998 Excellent Teacher for Adult High Education Nanjing University of Traditional Chinese Medicine Professional Societies 2

3 Founding member, International Chemical Biology Society (ICBS), USA Managing Director, Translation Committee, World Federation of Chinese Medicine Societies Jiangsu Committee of Integration of Western Medicine and Traditional Chinese Medicine Jiangsu Committee of Immunology Research Interests Systems biology approach of herbal prescriptions and compounds Anticancer herbal function in signaling networks Editorial Boards Editorial Board member, Journal of Cancer Inventions Zhang, Xu, and Lu, Tulin, et. al. Application of Ophiopogonin D in regulating signaling genes of vascular endothelial cells ZL , China patent Zhang, Xu, and Lu, Tulin, et. al. Application of Ophiopogonin D in regulating apoptosis genes of vascular endothelial cells ZL , China patent Zhang, Xu, and Lu, Tulin, et. al. Application of Ophiopogonin D in regulating cell-cycle genes of vascular endothelial cells ZL , China patent Yin, Lian, and Zhang, Xu, et. al. Herbal extraction against the proliferation of A549 and its preparation ZL , China patent Ye, Lihong, and Zhang, Xu, et. al. Herbal polysaccharides extraction against the proliferation of A549 and its preparation ZL , China patent Zhang, Xu, and Tang, Yuping, et. al. Extraction of Maimendong & Qianjin Weijing Decoction against the proliferation of H460 and its preparationapplication , China patent Jiang, Ming, and Zhang, Xu, et. al. Extraction of Maimendong & Qianjin Weijing Decoction against the proliferation of A549 and its preparationapplication. ZL , China patent Tang, Yuping, and Zhang, Xu, et. al. Normal butanol extraction of Maimendong & Qianjin Weijing Decoction against the proliferation of A549 and its preparation , China patent Research Support Federally funded: 3

4 FP7---Marie Curie Action---IRSES project: CHETCH (China and Europe taking care of healthcare solutions), No , , 688,800EUR Zhang (Steering Committee, task leader) Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumor, , 1.65 million RMB Zhang (Associate Director) The Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions: Occurrence and evaluation in diseases suitable for the treatment by integrated Chinese and western medicine, , Program Budget:2.65 million RMB Zhang (task leader) National S & T Supporting Program in Chinese Medicine for the 11th Five-Year Plan: Evaluation of Herbal Formula and Effective Ingredients by System Biology, No: 2006BAI11B08, , Program Budget: 5.3million RMB Zhang (PI) Project supported by National Natural Science foundation of China: Study of effective components of Radix Ophiopogonis on signal transduction and gene expression of apoptotic VEC, No: , Zhang (PI) Project supported by Jiangsu Provincial Education Committee: Molecular Research of blood stasis treated by herbs of nourishing yin, invigorating qi and activating blood circulation. No: 00KJD360003, Zhang (PI) Project supported by National Bureau of Traditional Chinese Medicine: Molecular mechanism of VEC apoptosis against by herbs of nourishing yin, invigorating qi and activating blood circulation. No: 2000-J-Q-08, Zhang (PI) Reviewer for scientific journals and Projects National Science Foundation, China International Exchange Expert in Chinese Medicine, National Bureau of Chinese Medicine Journal of Cancer OMICS: A Journal of Integrative Biology Journal of Nanjing University of Chinese Medicine Journal of World Infection Professional activities: Clinical Interpreter in Internal Medicine, Pediatrics, Genecology and Acupuncture, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Interpreter of Medical History Museum and Staff Journal, Nanjing University of Traditional Chinese Medicine, Invited Seminar and Conference Presentations 2015 Drug Screening and Discovery Technologies Asian Forum 4

5 2012 The 1st Official conference of the ICBS, Cambridge, MA 2011 The inaugural meeting of ICBS, Kansas, USA 2008 The 9th international congress on cell biology, Soul, Korea 2008 International Forum on Chinese Medicine, Nanjing, Jiangsu 2007 Sino-European Conference on Traditional Chinese Medicine International Cooperation and Perspective in Science and Technology, Roma, Italy 2006 The 3 rd International Congress of Traditional Medicine, Toronto, Canada, 2006 International Forum on Innovation and Development Situation of Traditional Medicine, Beijing, China 2006 The 9th International Congress on Ethnopharmacology (NICE), Nanning, China 2006 National 8 th Congress on New Techniques, Achievements and Experiences of Chinese Medicine, Huhehot, China 2006 Herbal Medicines Conference, May 23-25, Kota Kinabalu, Malaysia 2006 Recent Trends of Natural Medicine Researches Program, Nanjing, China Teaching Experience Nanjing University of Chinese Medicine: (i) Immunology (lectures; present) (ii) Microbiology (lectures; present) (iii) Specialized English of Chinese Medicine (lectures; 2004-present) (iv) Specialized English of International Nursing (lectures; 2007) Macau University of Science and Technology: (i) Microbiology & Immunology (lectures; ) (ii) Cell Biology(lectures; 2004) (iii) Specialized English of Chinese Medicine (lectures; 2004) Publications Jie Zhu, Meijuan Chen, Ning Chen, Aizhen Ma, Chunyan Zhu, Ruolin Zhao, Miao Jiang, Jing Zhou, Lihong Ye, Haian Fu and Xu Zhang. Glycyrrhetinic acid induces G1 phase cell cycle arrest in human non small cell lung cancer cells through endoplasmic reticulum stress pathway. international journal of oncology 46: , 2015 Wang X, Chen M, Zhou J, Zhang X. HSP27, 70 and 90, antiapoptotic proteins, in clinica l cancer therapy (Review). Int J Oncol. 2014, 45(1): Zhou J, Zhou TY, Chen MJ, Zhang X, et al. Research progress on synergistic anti-tumor mechanisms of compounds in Traditional Chinese Medicine [J]. Journal of Traditional Chinese Medicine, 2014,34(1): Jian Ping Chen, De Guo Xu, Xiao Yi Yu, Feng Ming Zhao, Dong Qing Xu, Xu Zhang, Bao Chang Cai and Ming-Yan Wang,Discrepancy between the effects of morronside on apoptosis in human embryonic lung fibroblast cells and lung cancer A549 cells,oncology LETTERS 7: ,

6 Xu WA, Yin L, Pan HY, Shi L, Xu L, Zhang X, Duan JA. Study on the correlation between constituents detected in serum from Rhizoma Smilacis Glabrae and the reduction of uric acid levels in hyperuricemia. J Ethnopharmacol Nov 25;150(2): Xiong F, Jiang M, Huang Z, Chen M, Chen K, Zhou J, Yin L, Tang Y, Wang M, Ye L, Zhan Z, Duan J, Fu H, Zhang X. A novel herbal formula induces cell cycle arrest and apoptosis in association with suppressing the PI3K/AKT pathway in human lung cancer A549 cells. Integr Cancer Ther Mar;13(2): Zheng L, Zhang W, Jiang M, Zhang H, Xiong F, Yu Y, Chen M, Zhou J, Dai X, Tang Y, Jiang M, Wang M, Cheng G, Duan J, Yu W, Lin B, Fu H, Zhang X. Expression Profiling and Proteomic Analysis of JIN Chinese Herbal Formula in Lung Carcinoma H460 Xenografts. Evid Based Complement Alternat Med. 2013;2013: Jiang F, Jiang R, Zhu X, Zhang X, Zhan Z (2013) Genipin Inhibits TNF-α-Induced Vascular Smooth Muscle Cell Proliferation and Migration via Induction of HO-1. PLoS ONE 8(8): e Meijuan Chen, Yuhong Du, Min Qui, Mingyan Wang, Kejun Chen, Zhenzhou Huang, Miao Jiang, Fei Xiong, Jianping Chen, Jing Zhou, Fengrong Jiang, Lian Yin, Yuping Tang, Lihong Ye, Zhen Zhan, Jin-Αo Duan, Hai-Αn Fu, Xu Zhang, Ophiopogonin B-induced autophagy in non-small cell lung cancer cells via inhibition of the PI3K/Akt signaling pathway, Oncology Report, 2011, 11 Jing Zhou, Jiankun Zhu, Meijuan Chen, Miao Jiang, Zongming Zhang, Zhen Zhan, Xu Zhang. Chinese medicine dialectical thought and logic application [J]. Journal of Traditional Chinese Medicine, 2012 Weixia Li, Nianguang Li, Yuping Tang, Baoquan Li, Li Liu, Xu Zhang, Haian Fu, Jinao Duan. Biological activity evaluation and structure-activity relationships analysis of ferulic acid and caffeic acid derivatives for anticancer. Bioorganic & Medicinal Chemistry Letters, 2012, 22 (19): Y Zhou, Z Huang, M Jiang, Y Tang, M Jiang, J Ma, Z Zhan, J Duan, X Zhang, Inhibiting Prosurvival Pathways by Extracts of Ophiopogon japonicus & Phragmititis Caulis Decoction on Human A549 and H157 Lung Cancer Cells, Supportive Care in Cancer, Volume 19, Supplement 2, June 2011, Abstracts of the 2011 International MASS/ISOO Symposium Yuhui Zhou Fei Xiong, Zhenzhou Huang, Luyu Zheng, Miao Jiang, Ming Jiang,Yuping Tang, Jian Ma, Zhen Zhan, Jinao Duan, Xu Zhang, JIN Formula inhibits tumorigenesis pathways in human lung carcinoma cells and tumor growth in athymic nude mice, Recent advances in theories and practice of CHINESE MEDICINE,, ISBN , In Tech Wang MY, Zhao FM, Peng HY, Lou CH, Li Y, Ding X, Yu XY, Yang GM, Xu DQ, Jiang LH, Zhang X, Ye LH, Cai BC.Investigation on the morphological protective effect of 5-hydroxymethylfurfural extracted from wine-processed Fructus corni on human L02 hepatocytes. J Ethnopharmacol May 31. Qian J, Jiang F, Wang B, Yu Y, Zhang X, Yin Z, Liu C.J Ophiopogonin D prevents H2O2-induced injury in primary human umbilical vein endothelial cells. Ethnopharmacol Mar 24;128(2): Epub 2010 Jan 18. Book 6

7 1. Medical Genetics,China Publishing House of Chinese Medicine,2007, USBN (English editor) The New Century Chinese-English Dictionary of Traditional Chinese Medicine, People s Military Medical Press, 2004, ISBN New edition of Chinese Preventive Medicine,People s Medical Press, 2004, ISBN Diagnosis and Treatment of Internal Medicine by Modern Chinese Medicine, People s Medical Publishing House, 2001, ISBN /R Molecular Biology and Development of Chinese Materia Medica, People s Medical Publishing House, Molecular Biology and Traditional Chinese Medicine, People s Medical Publishing House, Chinese-English Dictionary of Sporting Terms, People s Sports Publishing House, Exercises of Microbiology and Parasitology, Publishing House of Shanghai University of Traditional Chinese Medicine, (Deputy editor)chinese-english Clinical Dialogues in Traditional Chinese Medicine, Publishing House of Shanghai University of TCM,