3 rd course on BREAST CANCER: FROM CLINICS TO BIOLOGY June 19-23, 2017 Institut Curie - Training Unit - International Course

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1 08/03/2017 Monday, june 19 th : Clinical management Chair: Roman Rouzier 10:15 Training Unit Welcome: practical aspects & coffee 10:30 11:15 11:15 11:45 Anne Vincent-Salomon & Roman Rouzier Mathilde His Anne Vincent-Salomon Welcome & introduction to the course Breast cancer epidemiology Breast cancer classification 11:45 12:05 Paper discussion Anne Tardivon Breast imaging: current concepts & controversies 14:40 14:40 15:00 Fabien Reyal Youlia Kirova Surgery: standards of care & perspectives Radiation therapy: standard of care and innovations 15:00 15:50 15:50 Etienne Brain Therapies in HR+ breast cancer 17:10 Véronique Diéras CLCC Eugène Marquis, Rennes - FR Suzette Delaloge Therapies in HER2+ breast cancer Therapies in triple negative breast cancer 17:10 17:30

2 08/03/2017 Tuesday, june 20 th : Genomics & Epigenomics Chair: Anne Vincent-Salomon 09:45 Jorge Reis-Filho Memorial Sloan Kettering Cancer Center, New York - USA Clinical impact of genomic classifications 09:45 10:05 10:05 10:50 Helen Davies Sanger Institute, Hinxton - UK Mutational signatures: tracking the origins of breast cancer 10:50 12:30 Alain Viari INRIA & Centre Léon Bérard, Lyon - FR Mechanisms of HER2 amplification 12:30 15:15 15:15 15:35 Claude Houdayer Charlotte Proudhon Current questions in germline diagnosis Circulating tumor cells & DNA 15:35 16:15 16:00 Raphaël Margueron Epigenetics in breast cancer 17:20 Philippe Chavrier Insights into in situ to invasive transition 17:20 17:40 17:40 18:30 POSTER SESSION #1 BDD Annexes

3 Wednesday, june 21 st : Microenvironment Chair: Fatima Mechta-Grigoriou Silvia Fre Mammary gland development Fatima Mechta-Grigoriou Breast cancer stroma 12:00 Olivier Herault CHU Tours, Tours - FR Stromal niche 12:00 13:30 Green Café 13:30 Laurence Zitvogel Fundamental basis of cancer immune therapy 15:10 Emanuela Romano Current status of immune therapy in breast cancer 15:10 François Ringeisen Laboratoires Lilly, Geneva - CH Research in Pharma POSTER SESSION #2 BDD Annexes

4 Thursday, june 22 nd : Resistance and metastases Chair: Jean-Yves Pierga Stéphan Vagner Institut Curie, Orsay - FR RNA biology and resistance to treatment in breast cancer Antonin Morillon Non coding genome & breast cancer 11:55 11:55 12:15 Muriel le Romancer Centre Léon Bérard, Lyon - FR Biology of estrogen receptor 12:15 13:45 13:45 Charlotte Ng University Hospital, Basel - CH Bioinformatics Paul Cottu Natural history and genomics of metastases 17:00 Carlos Caldas CRUK, Cambridge - UK Breast cancer heterogeneity 17:30 22:00 COCKTAIL & PARTY Chez Marie

5 Friday, june 23 rd : Experimental models Chairs: Stephan Vagner 10:00 Jos Jonkers NKI, Amsterdam - NL Mice preclinical models 11:05 11:05 11:50 Philippe Juin Université de Nantes, Nantes - FR Organoids and in vitro models 11:50 14:25 Christophe Ginestier Inserm U891, Marseille - FR Breast cancer stem cells 14:25 14:45 14:45 15:30 Roberto Buccione EMBO Molecular Medicine, Heidelberg - DE Publishing your paper 15:30 15:45 Roman Rouzier Course wrap-up

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