A Proposed Strategy for Treatment of Superficial Carcinoma. in the Thoracic Esophagus Based on an Analysis. of Lymph Node Metastasis

Size: px
Start display at page:

Download "A Proposed Strategy for Treatment of Superficial Carcinoma. in the Thoracic Esophagus Based on an Analysis. of Lymph Node Metastasis"

Transcription

1 Kitakanto Med J 2002 ; 52 : A Proposed Strategy for Treatment of Superficial Carcinoma in the Thoracic Esophagus Based on an Analysis of Lymph Node Metastasis Susumu Kawate,' Susumu Ohwada,' Tetsushi Ogawa,' Takao Okano,' Seiji Nakamura,' Yoshiyuki Kawasima,' Naoki Tomizawa,' Izumi Takeyoshi,' Osamu Kawamura,2 Motoyasu Kusano2 and Yasuo Morishita 1 Background and Aims : To determine the optimal treatment of superficial carcinoma of the thoracic esophagus, we retrospectively analyzed the site and prevalence of lymph node metastases in three-field dissection specimens removed during radical esophagectomy. Methods : We reviewed the medical charts and surgical and histopathological reports of 34 patients with superficial carcinoma of the thoracic esophagus, who were treated with esophagectomy and three-field lymph node dissection. Results : Lymph node metastases were found in 14 of 34 patients (41%). None of five cases with tumor invasion of only the pep or plpm had lymph node metastases. However, the prevalence of lymph node metastases from tumors that invaded the pmm or psm was 22% and 60%, respectively. Even when the cancer was located in the lower esophagus, the prevalence of cervical lymph node metastases was 20%. Two of three (67%) patients had cervical lymph node metastases even when there were no metastases in mediastinal nodes ("jumping lymph node metastases"). The 5-year survival rates in patients with and without lymph node metastases were 83% and 100%, respectively. Conclusions : A radical esophagectomy with three-field lymph node dissection should be performed on patients who have superficial carcinoma of the thoracic esophagus that invades the pmm or deeper. (Kitakanto Med J 2002 ; 52 : ) Key Words : Superficial esophageal carcinoma, Three-field dissection, Lymph node metastasis Introduction Esophageal carcinoma has a poor prognosis. Lymph node metastasis is an important factor in the prognosis.1,2 An extended radical lymphadenectomy has been advocated, but its efficacy has not been demonstrated in well-controlled, randomized trials. The presence or absence of lymph node metastasis is the key factor in determining the treatment of superficial carcinoma of the esophagus. Endoscopic mucosal resection (EMR) is the standard treatment for esophageal carcinoma that invades only the intraepithelial (pep) or lamina propria mucosae (plpm), because lymph node metastases from such tumors are rare. However, there is no accepted standard for treating esophageal carcinoma that invades the muscularis mucosae (pmm) or the submucosa (psm). The purpose of this study was to analyze the site and prevalence of lymph node metastases from superficial carcinoma of the thoracic esophagus, in specimens from radical esophagectomy with three-field lymph node dissection, in order to determine an optimal treatment. Patients and Methods Between June 1979 and October 2001, 150 patients with thoracic esophageal carcinoma underwent a thoracic esophagectomy through a right thoracotomy at the Second Department of Surgery, Gunma University 1 Second Department of Surgery, Gunma University Faculty of Medicine, Maebashi,Gunma , Japan 2 Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Maebashi, Gunma , Japan Received : March 5, 2002 Address : SUSUMU OHWADA Second Department of Surgery, Gunma University Faculty of Medicine, Showa-machi , Maebashi, Gunma , Japan

2 190 Strategy for Superficial Esophageal Carcinoma Hospital. Between February 1986 and October 2001, 96 of these patients had three-field lymph node dissection, and 36 of those patients had histologically proven superficial carcinoma. We reviewed the medical charts and surgical and histopathological reports of those 36 patients. Two patients who received preoperative adjuvant chemotherapy were excluded from the Table 1. Patient characteristics study. Data from the charts of the remaining 34 patients were analyzed (Table 1). All variables were expressed in the terminology of the Japanese Society for Esophageal Diseases.4 There were 27 males and 7 females, with a mean age of 65 years (range 50 to 79). Seven patients had carcinoma in the upper part (Ut), 22 in the middle part (Mt), and 5 in the lower part (Lt) of the thoracic esophagus. A curative resection was intended in all cases. A retrosternal route for reconstruction was selected for 18 patients, and a posterior mediastinal route for 16. The stomach was used for esophageal replacement in 23 patients, the colon in 7 and the jejunum in 4. The histological depth of tumor invasion was the pep in one patient, the plpm in 4, the pmm in 9 and the psm in 20. Five patients had EMR prior to radical esophagectomy. Submucosal cancer invasion was classified as sm 1 in the upper third, sm2 in the middle third, and sm3 in the lower third of the submucosa. The histological classification of the primary tumors of 32 patients was squamous cell carcinoma, well differentiated in 12, moderately differentiated in 14, and poorly differentiated in 6. The histological classification was adeno-squamous cell carcinoma in one patient and undifferentiated carcinoma in another. The designation for identifying resected lymph nodes in three-field dissection specimens is presented in Figure 1. All lymph nodes dissected from resection Fig. 1. Lymph node number is that used by the Japanese Society for Esophageal Disease.

3 191 Table 2. Lymph node metastasis in relation to tumor location and depth of invasion Table 3. Field of lymph node metastases in relation to location of primary tumor Table 4. Patients with cervical lymph node metastases without metastases to the upper mediastinum specimens were examined histologically after formalin fixation. Statistical analysis was performed using the StatView J-5.0 program (SAS Institute Inc., Cary, NC). The chi-square test and Fisher's exact test were used for group comparison. Cancer-related survival curves were generated by the Kaplan-Meier method, and the log-rank test was used to compare the curves. P ƒ 0.05 was considered statistically significant. Results Lymph node metastases Lymph node metastases were found in 14 of 34 patients (41 %) who underwent three-field dissection for a superficial carcinoma of the thoracic esophagus. The relationship between lymph node metastases and the location and depth of the tumor is presented in Table 2. The prevalence of lymph node metastases from tumors of the Ut, Mt, and Lt were 29%, 45%, and 40%, respectively. There was no correlation between prevalence of metastasis and location of the primary tumor. None of the five patients whose tumors invaded only the pep or plpm layers had lymph node metastases. However, the prevalence of lymph node metastases from tumors that had invaded the pmm or psm was 22% and 60%, respectively. The prevalence of lymph node metastases from tumors with invasion depths of sm 1, sm2, and sm3 was 50%, 60%, and 69%, respectively. As the depth of tumor invasion increased beyond the level of the plpm, the prevalence of lymph node metastases also increased. Table 3 lists the relationship of the percent of cases with lymph node metastases in each field with the location of the primary cancer. The prevalence of lymph node metastases in the neck, thorax, and abdomen was 9%, 21%, and 21%, respectively. Metastases to cervical lymph nodes were even found in one of 5 patients (20%) with a primary tumor in the Lt. Two of 3 patients (67%) with cervical lymph node metastases had no metastases in mediastinal nodes ("jumping lymph node metastases") (Table 4). Jumping lymph node metastases to cervical nodes even occurred from a tumor located in the Lt. Survival rates Cancer-related survival data of patients who underwent three-field lymph node dissection is shown in Fig. 2. The median follow-up time was 3.2 years (range : 3 months to 11.3 years). Five-year survival rates in patients with and without lymph node metastasis were 83% and 100%, respectively.

4 192 Strategy for Superficial Esophageal Carcinoma Survival Curve positron emission tomography with 18-F-fluorodeoxy-D-glucose (FDG-PET) are used to estimate the depth of invasion and identify lymph node metastasis.5 `7 EUS is one of the most useful modalities for the estimation of tumor depth, but accurate and sensitive preoperative diagnosis is often difficult.5 `7 EMR, another technique used to evaluate the depth of tumor invasion, has also been used for curative treatment of superficial esophageal carcinoma limited to the plpm. When feasible, EMR is the treatment of choice for superficial carcinoma that has invaded the pmm or psm. The final decision to perform an esophagectomy should be based on histological evidence of tumor invasion depth and vascular invasion from EMR specimens (diagnostic EMR). If there is tumor invasion of the pmm without vascular involvement, a Fig. 2. Cancer-related survival curves of patients who had threefield lymph node dissection. careful evaluation of patient status and detailed informed consent are necessary in order to plan an esophagectomy after EMR. A radical esophagectomy Tumor recurrence All patients who had no microscopic evidence of lymph node metastases are recurrence-free. Cancer subsequently recurred in 3 of 14 patients (21%) with lymph node metastases. One patient developed metastasis in a cervical lymph node, another one had metastases to the peritoneum and pleura, and the third had bone metastasis. Discussion In this study, the prevalence of lymph node metastases in patients with a superficial carcinoma of the thoracic esophagus was 43% at the time of esophagectomy. There was no difference in the prevalence of metastases from primary tumors in the upper, middle, or lower esophagus. Extensive metastases to the cervical, thoracic, and abdominal nodes occurred not only from deeply invasive, advanced carcinoma, but also from superficial tumors. One of the five patients (20%) with cancer of the lower esophagus had cervical lymph node metastases. In addition, 67% of the patients who had metastases in cervical lymph nodes had no metastasis in upper mediastinal nodes. We recommend, therefore, that cervical lymph nodes should be removed, even if the primary tumor is located in the lower esophagus, and even if there is no histologic evidence of metastases in the upper paraesophageal (# 105) or paratracheal (# 106) lymph nodes. In our study, the prevalence of lymph node metastasis was high when a tumor had invaded the pmm. Thus, an accurate determination of the depth of tumor invasion is the crucial factor on which treatment of superficial esophageal carcinoma is based. CT and MRI scans, endoscopic ultrasonography (EUS), and with three-field lymph node dissection is recommended for superficial esophageal carcinoma that involves the pmm or psm, because the risk of lymph node metastases is high. The overall survival of patients who undergo threefield lymph node dissection is reported to be better than that of patients who have only two-fields removed, but there have been no randomized controlled studies.8-10 On the other hand, three-field dissection has been reported to increase mortality and morbidity, particularly recurrent laryngeal nerve damage and leakage of anastomoses.9 `11 In our previous study, mortality rates and postoperative courses were similar for patients who had radical esophagectomy with either two- or three-field lymph node dissection.12 Indeed, in that series of patients with superficial esophageal carcinoma, anastomosis leakage or laryngeal nerve paralysis occurred in only two patients (3% of the study population). In conclusion, an esophagectomy with three-field lymph node dissection should be performed when a superficial carcinoma of the thoracic esophagus invades into or below the pmm. References 1. Kodama M, Kakegawa T. Treatment of superficial cancer of the esophagus : A summary of responses to a questionnaire on superficial cancer of the esophagus in Japan. Surgery 1998 ; 123 : Tajima Y, Nakanishi Y, Ochiai A, et al. Histopathologic findings predicting lymph node metastasis and prognosis of patients with superficial esophageal carcinoma : Analysis of 240 surgically resected tumors. Cancer 2000 ; 15 : 1285-

5 Ohwada S, Nakamura S, Izumi M, et al. Neoadjuvant chemotherapy with etoposide, leucovorin, 5-fluorouracil and cisplatin for advanced esophageal squamous cell carcinoma. Jpn J Clin Oncol 1995 ; 25 : Japanese Society for Esophageal Disease. Guidelines for clinical and pathologic studies on carcinoma of the esophagus (9 th ed). Kanehara, Tokyo, Japan 5. Fukuda M, Hirata K, Natori H. Endoscopic ultrasonography of the esophagus. World J Surg 2000 ; 24 : Lerut T, Flamen P, Ectors N, et al. Histopathologic validation of lymph node staging with FDG-PET scan in cancer of the esophagus and gastroesophageal junction : A prospective study based on primary surgery with extensive lymphadenectomy. Ann Surg 2000 ; 232 : Flamen P, Lerut A, Van Cutsem E, et al. Utility of positron tomography for the staging of patients with potentially operable esophageal carcinoma. J Clin Oncol 2000 ; 15 : Ogawa T, Ohwada S, Kawashima K, et al. Patterns of lymph node metastasis in three-field dissection for thoracic esophageal carcinoma : Optimal extension of lymph node dissection. Kitakanto Med J 1998 ; 48 : Isono K, Sato H, Nakayama K. Results of a nationwide study on the three-field lymph node dissection of esophageal cancer. Oncology 1991 ; 48 : Fujita H, Kakegawa T, Yamada H, et al. Mortality and morbidity rates, postoperative course, quality of life, and prognosis after extended radical lymphadenectomy for esophageal cancer : Comparison of three-field lymphadenectomy with two-field lymphadenectomy. Ann Surg 1995 ; 222 : Baba M, Aikou T, Yoshinaka H, et al. Longterm results of subtotal esophagectomy with threefield lymphadenectomy for carcinoma of the thoracic esophagus. Ann Surg 1994 ; 219 : Ohwada S, Ogawa T, Kawate S, et al. Omentoplasty for cervical esophagogastrostomy following radical esophagectomy with three-field dissection. Hepatogastroenterol ; 47 :

Case Scenario 1. The patient has now completed his neoadjuvant chemoradiation and has been cleared for surgery.

Case Scenario 1. The patient has now completed his neoadjuvant chemoradiation and has been cleared for surgery. Case Scenario 1 July 10, 2010 A 67-year-old male with squamous cell carcinoma of the mid thoracic esophagus presents for surgical resection. The patient has completed preoperative chemoradiation. This

More information

Lymph node metastasis is one of the most important prognostic

Lymph node metastasis is one of the most important prognostic ORIGINAL ARTICLE Comparison of Survival and Recurrence Pattern Between Two-Field and Three-Field Lymph Node Dissections for Upper Thoracic Esophageal Squamous Cell Carcinoma Young Mog Shim, MD, Hong Kwan

More information

Comparison of Surgical Management of Thoracic Esophageal Carcinoma Between Two Referral Centers in Japan and China

Comparison of Surgical Management of Thoracic Esophageal Carcinoma Between Two Referral Centers in Japan and China Jpn J Clin Oncol 2001;31(5)203 208 Comparison of Surgical Management of Thoracic Esophageal Carcinoma Between Two Referral Centers in Japan and China Wentao Fang 1,HoichiKato 2, Wenhu Chen 1,YujiTachimori

More information

Clinicopathological Characteristics and Outcome Indicators of Stage II Gastric Cancer According to the Japanese Classification of Gastric Cancer

Clinicopathological Characteristics and Outcome Indicators of Stage II Gastric Cancer According to the Japanese Classification of Gastric Cancer Clinicopathological Characteristics and Outcome Indicators of Stage II Gastric Cancer According to the Japanese Classification of Gastric Cancer HITOSHI OJIMA 1, KEN-ICHIRO ARAKI 1, TOSHIHIDE KATO 1, KAORI

More information

Controversies in management of squamous esophageal cancer

Controversies in management of squamous esophageal cancer 2015.06.12 12.47.48 Page 4(1) IS-1 Controversies in management of squamous esophageal cancer C S Pramesh Thoracic Surgery, Department of Surgical Oncology, Tata Memorial Centre, India In Asia, squamous

More information

Mucosal Esophageal Squamous Cell Carcinoma With Intramural Gastric Metastasis Invading Liver and Pancreas: A Case Report

Mucosal Esophageal Squamous Cell Carcinoma With Intramural Gastric Metastasis Invading Liver and Pancreas: A Case Report Int Surg 2014;99:458 462 DOI: 10.9738/INTSURG-D-13-00069.1 Case Report Mucosal Esophageal Squamous Cell Carcinoma With Intramural Gastric Metastasis Invading Liver and Pancreas: A Case Report Nobuhiro

More information

Characteristics of intramural metastasis in gastric cancer. Tatsuya Hashimoto Kuniyoshi Arai Yuichi Yamashita Yoshiaki Iwasaki Tsunekazu

Characteristics of intramural metastasis in gastric cancer. Tatsuya Hashimoto Kuniyoshi Arai Yuichi Yamashita Yoshiaki Iwasaki Tsunekazu ORIGINAL ARTICLE Characteristics of intramural metastasis in gastric cancer Tatsuya Hashimoto Kuniyoshi Arai Yuichi Yamashita Yoshiaki Iwasaki Tsunekazu Hishima Author for correspondence: T. Hashimoto

More information

International Surgery A case of surgical resection for superficial esophageal cancer with a single giant N4 cervical lymph node metastasis

International Surgery A case of surgical resection for superficial esophageal cancer with a single giant N4 cervical lymph node metastasis International Surgery A case of surgical resection for superficial esophageal cancer with a single giant N4 cervical lymph node metastasis --Manuscript Draft-- Manuscript Number: Full Title: Article Type:

More information

The esophageal submucosal glands are considered to be a continuation

The esophageal submucosal glands are considered to be a continuation 248 Significance of Involvement by Squamous Cell Carcinoma of the Ducts of Esophageal Submucosal Glands Analysis of 201 Surgically Resected Superficial Squamous Cell Carcinomas Yusuke Tajima, M.D. 1,2

More information

7/20/2017. Esophageal Cancer: A Less Common But Deadly Cancer. Objectives. Disclosure Statement NYNPA Conference October Saratoga New York

7/20/2017. Esophageal Cancer: A Less Common But Deadly Cancer. Objectives. Disclosure Statement NYNPA Conference October Saratoga New York Esophageal Cancer: A Less Common But Deadly Cancer 2017 NYNPA Conference October 18-22 Saratoga New York Mary McGreal DNP, RN, ANP-C, CCRN, CMC, Adjunct Professor at Stony Brook University School of Nursing

More information

Abstracting Upper GI Cancer Incidence and Treatment Data Quiz 1 Multiple Primary and Histologies Case 1 Final Pathology:

Abstracting Upper GI Cancer Incidence and Treatment Data Quiz 1 Multiple Primary and Histologies Case 1 Final Pathology: Abstracting Upper GI Cancer Incidence and Treatment Data Quiz 1 Multiple Primary and Histologies Case 1 A 74 year old male with a history of GERD presents complaining of dysphagia. An esophagogastroduodenoscopy

More information

Classification of Recurrent Esophageal Cancer after Radical Esophagectomy with Two- or Three-field Lymphadenectomy

Classification of Recurrent Esophageal Cancer after Radical Esophagectomy with Two- or Three-field Lymphadenectomy Classification of Recurrent Esophageal Cancer after Radical Esophagectomy with Two- or Three-field Lymphadenectomy HIROYUKI KATO, MINORU FUKUCHI, TATSUYA MIYAZAKI, MASANOBU NAKAJIMA, HITOSHI KIMURA, AHMAD

More information

Received 16 June 2001; received in revised form 13 September 2001; accepted 13 September 2001

Received 16 June 2001; received in revised form 13 September 2001; accepted 13 September 2001 European Journal of Cardio-thoracic Surgery 20 (2001) 1089 1094 www.elsevier.com/locate/ejcts Clinicopathologic characteristics and survival of patients with clinical Stage I squamous cell carcinomas of

More information

Imaging in gastric cancer

Imaging in gastric cancer Imaging in gastric cancer Gastric cancer remains a deadly disease because of late diagnosis. Adenocarcinoma represents 90% of malignant tumors. Diagnosis is based on endoscopic examination with biopsies.

More information

Itasu Ninomiya 1*, Koichi Okamoto 1, Tomoya Tsukada 1, Hiroto Saito 1, Sachio Fushida 1, Hiroko Ikeda 2 and Tetsuo Ohta 1

Itasu Ninomiya 1*, Koichi Okamoto 1, Tomoya Tsukada 1, Hiroto Saito 1, Sachio Fushida 1, Hiroko Ikeda 2 and Tetsuo Ohta 1 Ninomiya et al. Surgical Case Reports (2015) 1:25 DOI 10.1186/s40792-015-0030-8 CASE REPORT Open Access Thoracoscopic radical esophagectomy and laparoscopic transhiatal lymph node dissection for superficial

More information

Surgical strategies in esophageal cancer

Surgical strategies in esophageal cancer Gastro-Conference Berlin 2005 October 1-2, 2005 Surgical strategies in esophageal cancer J. Rüdiger Siewert Department of Surgery, Klinikum rechts der Isar Technische Universität München Esophageal Cancer

More information

Lung cancer pleural invasion was recognized as a poor prognostic

Lung cancer pleural invasion was recognized as a poor prognostic Visceral pleural invasion classification in non small cell lung cancer: A proposal on the basis of outcome assessment Kimihiro Shimizu, MD a Junji Yoshida, MD a Kanji Nagai, MD a Mitsuyo Nishimura, MD

More information

Three-Field Lymph Node Dissection for Squamous Cell and Adenocarcinoma of the Esophagus

Three-Field Lymph Node Dissection for Squamous Cell and Adenocarcinoma of the Esophagus ANNALS OF SURGERY Vol. 236, No. 2, 177 183 2002 Lippincott Williams & Wilkins, Inc. Three-Field Lymph Node Dissection for Squamous Cell and Adenocarcinoma of the Esophagus Nasser Altorki, MD, Michael Kent,

More information

Research Article Analysis of Predictors for Lymph Node Metastasis in Patients with Superficial Esophageal Carcinoma

Research Article Analysis of Predictors for Lymph Node Metastasis in Patients with Superficial Esophageal Carcinoma Gastroenterology Research and Practice Volume 2016, Article ID 3797615, 6 pages http://dx.doi.org/10.1155/2016/3797615 Research Article Analysis of Predictors for Lymph Node Metastasis in Patients with

More information

Outcome after emergency surgery in patients with a free perforation caused by gastric cancer

Outcome after emergency surgery in patients with a free perforation caused by gastric cancer experimental and therapeutic medicine 1: 199-203, 2010 199 Outcome after emergency surgery in patients with a free perforation caused by gastric cancer Hironori Tsujimoto 1, Shuichi Hiraki 1, Naoko Sakamoto

More information

Esophageal cancer is a significant health hazard for

Esophageal cancer is a significant health hazard for Postoperative Radiotherapy Improved Survival of Poor Prognostic Squamous Cell Carcinoma Esophagus GENERAL THORACIC Junqiang Chen, MD, Ji Zhu, MD, Jianji Pan, MD, Kunshou Zhu, MD, Xiongwei Zheng, MD, Mingqiang

More information

Key words: gastric cancer, lymphovascular invasion, recurrence

Key words: gastric cancer, lymphovascular invasion, recurrence Key words: gastric cancer, lymphovascular invasion, recurrence 139 (2177) Table I Relationship between clinicopathologic factors and lymphatic invasion in 2146 patients with gastric cancer Factors P-value

More information

The right middle lobe is the smallest lobe in the lung, and

The right middle lobe is the smallest lobe in the lung, and ORIGINAL ARTICLE The Impact of Superior Mediastinal Lymph Node Metastases on Prognosis in Non-small Cell Lung Cancer Located in the Right Middle Lobe Yukinori Sakao, MD, PhD,* Sakae Okumura, MD,* Mun Mingyon,

More information

Esophageal Cancer. Wesley A. Papenfuss MD FACS Surgical Oncology Aurora Cancer Care. David Demos MD Thoracic Surgery Aurora Cancer Care

Esophageal Cancer. Wesley A. Papenfuss MD FACS Surgical Oncology Aurora Cancer Care. David Demos MD Thoracic Surgery Aurora Cancer Care Esophageal Cancer Wesley A. Papenfuss MD FACS Surgical Oncology Aurora Cancer Care David Demos MD Thoracic Surgery Aurora Cancer Care No Disclosures Learning Objectives Review the classification scheme

More information

Metachronous pulmonary metastasis after radical esophagectomy for esophageal cancer: prognosis and outcome

Metachronous pulmonary metastasis after radical esophagectomy for esophageal cancer: prognosis and outcome Takemura et al. Journal of Cardiothoracic Surgery 2012, 7:103 RESEARCH ARTICLE Open Access Metachronous pulmonary metastasis after radical esophagectomy for esophageal cancer: prognosis and outcome Masashi

More information

Diagnosis and Surgical Outcomes for Primary Malignant Melanoma of the Esophagus: A Single-Center Experience

Diagnosis and Surgical Outcomes for Primary Malignant Melanoma of the Esophagus: A Single-Center Experience Diagnosis and Surgical Outcomes for Primary Malignant Melanoma of the Esophagus: A Single-Center Experience Shaohua Wang, MD, Yuji Tachimori, MD, Nobukazu Hokamura, MD, Hiroyasu Igaki, MD, Takayoshi Kishino,

More information

Yuanli Dong 1,2, Hui Guan 1,2, Wei Huang 1, Zicheng Zhang 1, Dongbo Zhao 3, Yang Liu 1,3, Tao Zhou 1, Baosheng Li 1.

Yuanli Dong 1,2, Hui Guan 1,2, Wei Huang 1, Zicheng Zhang 1, Dongbo Zhao 3, Yang Liu 1,3, Tao Zhou 1, Baosheng Li 1. Original Article Precise delineation of clinical target volume for crossingsegments thoracic esophageal squamous cell carcinoma based on the pattern of lymph node metastases Yuanli Dong 1,2, Hui Guan 1,2,

More information

LYMPH NODE METASTASIS IN SMALL PERIPHERAL ADENOCARCINOMA OF THE LUNG

LYMPH NODE METASTASIS IN SMALL PERIPHERAL ADENOCARCINOMA OF THE LUNG LYMPH NODE METASTASIS IN SMALL PERIPHERAL ADENOCARCINOMA OF THE LUNG Tsuneyo Takizawa, MD a Masanori Terashima, MD a Teruaki Koike, MD a Takehiro Watanabe, MD a Yuzo Kurita, MD b Akira Yokoyama, MD b Keiichi

More information

How to stage early BE cancer - EUS or endoscopic removal?

How to stage early BE cancer - EUS or endoscopic removal? How to stage early BE cancer - EUS or endoscopic removal? Presented by Bas Weusten Institution St. Antonius Hospital, Nieuwegein Academic Medical Center, Amsterdam case 56 y old female patient Lung transplant

More information

Index. Surg Oncol Clin N Am 16 (2007) Note: Page numbers of article titles are in boldface type.

Index. Surg Oncol Clin N Am 16 (2007) Note: Page numbers of article titles are in boldface type. Surg Oncol Clin N Am 16 (2007) 465 469 Index Note: Page numbers of article titles are in boldface type. A Adjuvant therapy, preoperative for gastric cancer, staging and, 339 B Breast cancer, metabolic

More information

The lymph nodes (LNs) around the recurrent laryngeal

The lymph nodes (LNs) around the recurrent laryngeal GENERAL THORACIC A Strategy for Supraclavicular Lymph Node Dissection Using Recurrent Laryngeal Nerve Lymph Node Status in Thoracic Esophageal Squamous Cell Carcinoma Yusuke Taniyama, MD, Takanobu Nakamura,

More information

Case Scenario year-old white male presented to personal physician with dyspepsia with reflux.

Case Scenario year-old white male presented to personal physician with dyspepsia with reflux. Case Scenario 1 57-year-old white male presented to personal physician with dyspepsia with reflux. 7/12 EGD: In the gastroesophageal junction we found an exophytic tumor. The tumor occupies approximately

More information

INTRODUCTION. Jpn J Clin Oncol 2006;36(12) doi: /jjco/hyl105

INTRODUCTION. Jpn J Clin Oncol 2006;36(12) doi: /jjco/hyl105 The Range of Tumor Extension Should Have Precedence over the Location of the Deepest Tumor Center in Determining the Regional Lymph Node Grouping for Widely Extending Esophageal Carcinomas Jpn J Clin Oncol

More information

Successful Resection of Esophageal Carcinoma Associated with Double Aortic Arch: A Case Report

Successful Resection of Esophageal Carcinoma Associated with Double Aortic Arch: A Case Report Successful Resection of Esophageal Carcinoma Associated with Double Aortic Arch: A Case Report NAOSHI KUBO 1, MASAICHI OHIRA 1, YOSHITO YAMASHITA 2, KATSUNOBU SAKURAI 1, HIROAKI TANAKA 1, KAZUYA MUGURUMA

More information

We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists. International authors and editors

We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists. International authors and editors We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists 3,900 116,000 120M Open access books available International authors and editors Downloads Our

More information

COLLECTING CANCER DATA: STOMACH AND ESOPHAGUS

COLLECTING CANCER DATA: STOMACH AND ESOPHAGUS COLLECTING CANCER DATA: STOMACH AND ESOPHAGUS 2017 2018 NAACCR WEBINAR SERIES Q&A Please submit all questions concerning webinar content through the Q&A panel. Reminder: If you have participants watching

More information

Histopathology of Endoscopic Resection Specimens from Barrett's Esophagus

Histopathology of Endoscopic Resection Specimens from Barrett's Esophagus Histopathology of Endoscopic Resection Specimens from Barrett's Esophagus Br J Surg 38 oct. 1950 Definition of Barrett's esophagus A change in the esophageal epithelium of any length that can be recognized

More information

Prognostic factors in patients with thoracic esophageal carcinoma staged pt 1-4a N 0 M 0 undergone esophagectomy with three-field lymphadenectomy

Prognostic factors in patients with thoracic esophageal carcinoma staged pt 1-4a N 0 M 0 undergone esophagectomy with three-field lymphadenectomy Original Article Page 1 of 7 Prognostic factors in patients with thoracic esophageal carcinoma staged pt 1-4a N 0 M 0 undergone esophagectomy with three-field lymphadenectomy Xiaohui Chen 1, Junqiang Chen

More information

Three-field lymph node dissection in esophageal cancer surgery

Three-field lymph node dissection in esophageal cancer surgery Review Article Three-field lymph node dissection in esophageal cancer surgery Satoru Matsuda 1, Hiroya Takeuchi 1,2, Hirofumi Kawakubo 1, Yuko Kitagawa 1 1 Department of Surgery, Keio University School

More information

Esophageal cancer: Biology, natural history, staging and therapeutic options

Esophageal cancer: Biology, natural history, staging and therapeutic options EGEUS 2nd Meeting Esophageal cancer: Biology, natural history, staging and therapeutic options Michael Bau Mortensen MD, Ph.D. Associate Professor of Surgery Centre for Surgical Ultrasound, Upper GI Section,

More information

Quiz Adenocarcinoma of the distal stomach has been increasing in the last 20 years. a. True b. False

Quiz Adenocarcinoma of the distal stomach has been increasing in the last 20 years. a. True b. False Quiz 1 1. Which of the following are risk factors for esophagus cancer. a. Obesity b. Gastroesophageal reflux c. Smoking and Alcohol d. All of the above 2. Adenocarcinoma of the distal stomach has been

More information

ESOPHAGEAL CANCER AND GERD. Prof Salman Guraya FRCS, Masters MedEd

ESOPHAGEAL CANCER AND GERD. Prof Salman Guraya FRCS, Masters MedEd ESOPHAGEAL CANCER AND GERD Prof Salman Guraya FRCS, Masters MedEd Learning objectives Esophagus anatomy and physiology Esophageal cancer Causes, presentations of esophageal cancer Diagnosis and management

More information

SETTING Fudan University Shanghai Cancer Center. RESPONSIBLE PARTY Haiquan Chen MD.

SETTING Fudan University Shanghai Cancer Center. RESPONSIBLE PARTY Haiquan Chen MD. OFFICIAL TITLE A Phase Ⅲ Study of Left Side Thoracotomy Approach (SweetProcedure) Versus Right Side Thoracotomy Plus Midline Laparotomy Approach (Ivor-Lewis Procedure) Esophagectomy in Middle or Lower

More information

Minimally Invasive Esophagectomy: OVERRATED!!! Sagar Damle UCHSC December 11, 2006

Minimally Invasive Esophagectomy: OVERRATED!!! Sagar Damle UCHSC December 11, 2006 Minimally Invasive Esophagectomy: OVERRATED!!! Sagar Damle UCHSC December 11, 2006 Esophageal Cancer - Est. 15,000 cases in 2006 - Est. 14,000 deaths - Overall 5-year survival: 15.6% - 33.6 % for local

More information

Clinical study on postoperative recurrence in patients with pn0 esophageal squamous cell carcinoma

Clinical study on postoperative recurrence in patients with pn0 esophageal squamous cell carcinoma Guo et al. Journal of Cardiothoracic Surgery 2014, 9:150 RESEARCH ARTICLE Open Access Clinical study on postoperative recurrence in patients with pn0 esophageal squamous cell carcinoma Xu-feng Guo, Teng

More information

Clinicopathologic Characteristics and Prognosis of Gastric Cancer in Young Patients

Clinicopathologic Characteristics and Prognosis of Gastric Cancer in Young Patients Yonago Acta medica 2012;55:57 61 Clinicopathologic Characteristics and Prognosis of Gastric Cancer in Young Patients Hiroaki Saito, Seigo Takaya, Yoji Fukumoto, Tomohiro Osaki, Shigeru Tatebe and Masahide

More information

Significance of the lymph nodes in the 7th station in rational dissection for metastasis of distal gastric cancer with different T categories

Significance of the lymph nodes in the 7th station in rational dissection for metastasis of distal gastric cancer with different T categories Original Article Significance of the lymph nodes in the 7th station in rational dissection for metastasis of distal gastric cancer with different T categories Wu Song, Yulong He, Shaochuan Wang, Weiling

More information

OCCULT CERVICAL NODAL METASTASIS IN ESOPHAGEAL CANCER: PRELIMINARY RESULTS OF THREE-FIELD LYMPHADENECTOMY

OCCULT CERVICAL NODAL METASTASIS IN ESOPHAGEAL CANCER: PRELIMINARY RESULTS OF THREE-FIELD LYMPHADENECTOMY OCCULT CERVICAL NODAL METASTASIS IN ESOPHAGEAL CANCER: PRELIMINARY RESULTS OF THREE-FIELD LYMPHADENECTOMY Nasser K. Altorki, MD David B. Skinner, MD The extent of lymphadenectomy for carcinoma of the thoracic

More information

Determining the Optimal Surgical Approach to Esophageal Cancer

Determining the Optimal Surgical Approach to Esophageal Cancer Determining the Optimal Surgical Approach to Esophageal Cancer Amit Bhargava, MD Attending Thoracic Surgeon Department of Cardiovascular and Thoracic Surgery Open Esophagectomy versus Minimally Invasive

More information

malignant polyp Daily Challenges in Digestive Endoscopy for Endoscopists and Endoscopy Nurses BSGIE Annual Meeting 18/09/2014 Mechelen

malignant polyp Daily Challenges in Digestive Endoscopy for Endoscopists and Endoscopy Nurses BSGIE Annual Meeting 18/09/2014 Mechelen Plan Incidental finding of a malignant polyp 1. What is a polyp malignant? 2. Role of the pathologist and the endoscopist 3. Quantitative and qualitative risk assessment 4. How to decide what to do? Hubert

More information

Risk factors for cervical lymph node metastasis in superficial head and neck squamous cell carcinoma

Risk factors for cervical lymph node metastasis in superficial head and neck squamous cell carcinoma J Med Dent Sci 2015; 62: 19-24 Original Article Risk factors for cervical lymph node metastasis in superficial head and neck squamous cell carcinoma Toru Sasaki, MD 1, 2), Seiji Kishimoto, MD, PhD 1),

More information

Di Lu 1#, Xiguang Liu 1#, Mei Li 1#, Siyang Feng 1#, Xiaoying Dong 1, Xuezhou Yu 2, Hua Wu 1, Gang Xiong 1, Ruijun Cai 1, Guoxin Li 3, Kaican Cai 1

Di Lu 1#, Xiguang Liu 1#, Mei Li 1#, Siyang Feng 1#, Xiaoying Dong 1, Xuezhou Yu 2, Hua Wu 1, Gang Xiong 1, Ruijun Cai 1, Guoxin Li 3, Kaican Cai 1 Case Report Three-port mediastino-laparoscopic esophagectomy (TPMLE) for an 81-year-old female with early-staged esophageal cancer: a case report of combining single-port mediastinoscopic esophagectomy

More information

Prognostic and Clinical Evaluation of Axillary Lymph Node Metastasis in Esophageal Cancer

Prognostic and Clinical Evaluation of Axillary Lymph Node Metastasis in Esophageal Cancer Prognostic and Clinical Evaluation of Axillary Lymph Node Metastasis in Esophageal Cancer Shuhei Komatsu 1, Yuji Ueda 1, Daisuke Ichikawa 1, Hitoshi Fujiwara 1, Kazuma Okamoto 1, Shojiro Kikuchi 1, Atsushi

More information

Original articledote_1350. S. P. Mehta, 1 P. Jose, 1,2 A. Mirza, 3 S. A. Pritchard, 3 J. D. Hayden, 1 and H. I. Grabsch 2

Original articledote_1350. S. P. Mehta, 1 P. Jose, 1,2 A. Mirza, 3 S. A. Pritchard, 3 J. D. Hayden, 1 and H. I. Grabsch 2 1..7 Diseases of the Esophagus (2012), DOI: 10.1111/j.1442-2050.2012.01350.x Original articledote_1350 Comparison of the prognostic value of the 6th and 7th editions of the Union for International Cancer

More information

Michael A. Choti, MD, FACS Department of Surgery Johns Hopkins Medicine, Baltimore, MD

Michael A. Choti, MD, FACS Department of Surgery Johns Hopkins Medicine, Baltimore, MD Michael A. Choti, MD, FACS Department of Surgery Johns Hopkins Medicine, Baltimore, MD Surgical Therapy of Gastric Cancer CLINICAL QUESTIONS 1. How much of the stomach should be removed? 2. How many lymph

More information

Mucinous Adenocarcinoma of the Stomach Clinicopathological

Mucinous Adenocarcinoma of the Stomach Clinicopathological THE KURUME MEDICAL JOURNAL Vo1. 43, p. 289-294, 1996 ORIGINAL ARTICLE Mucinous Adenocarcinoma of the Stomach Clinicopathological Studies KIKUO KOUFUJI, JINRYO TAKEDA, ATSUSHI TOYONAGA, ISSEI KODAMA, KEISHIRO

More information

Xiang Hu*, Liang Cao*, Yi Yu. Introduction

Xiang Hu*, Liang Cao*, Yi Yu. Introduction Original Article Prognostic prediction in gastric cancer patients without serosal invasion: comparative study between UICC 7 th edition and JCGS 13 th edition N-classification systems Xiang Hu*, Liang

More information

Esophageal Cancer Initially Thought to be Accompanied by a Solitary Metastasis to an Intrathoracic Paraaortic Lymph Node

Esophageal Cancer Initially Thought to be Accompanied by a Solitary Metastasis to an Intrathoracic Paraaortic Lymph Node 2012 66 5 417 421 Esophageal Cancer Initially Thought to be Accompanied by a Solitary Metastasis to an Intrathoracic Paraaortic Lymph Node a b* a a a a a a a b ʼ 418 Horio et al. Acta Med. Okayama Vol.

More information

Surgical Problems in Proximal GI Cancer Management Cardia Tumours Question #1: What are cardia tumours?

Surgical Problems in Proximal GI Cancer Management Cardia Tumours Question #1: What are cardia tumours? Surgical Problems in Proximal GI Cancer Management Cardia Tumours Question #1: What are cardia tumours? Question #2: How are cardia tumours managed? Michael F. Humer December 3, 2005 Vancouver, BC Case

More information

doi: /j.ijrobp

doi: /j.ijrobp doi:10.1016/j.ijrobp.2010.08.037 Int. J. Radiation Oncology Biol. Phys., Vol. 82, No. 1, pp. 475 482, 2012 Copyright Ó 2012 Elsevier Inc. Printed in the USA. All rights reserved 0360-3016/$ - see front

More information

Management of Esophageal Cancer: Evidence Based Review of Current Guidelines. Madhuri Rao, MD PGY-5 SUNY Downstate Medical Center

Management of Esophageal Cancer: Evidence Based Review of Current Guidelines. Madhuri Rao, MD PGY-5 SUNY Downstate Medical Center Management of Esophageal Cancer: Evidence Based Review of Current Guidelines Madhuri Rao, MD PGY-5 SUNY Downstate Medical Center Case Presentation 68 y/o male PMH: NIDDM, HTN, hyperlipidemia, CAD s/p stents,

More information

Although esophagectomy remains the standard of care for esophageal

Although esophagectomy remains the standard of care for esophageal Keresztes et al General Thoracic Surgery Preoperative chemotherapy for esophageal cancer with paclitaxel and carboplatin: Results of a phase II trial R. S. Keresztes, MD J. L. Port, MD M. W. Pasmantier,

More information

Superior and Basal Segment Lung Cancers in the Lower Lobe Have Different Lymph Node Metastatic Pathways and Prognosis

Superior and Basal Segment Lung Cancers in the Lower Lobe Have Different Lymph Node Metastatic Pathways and Prognosis ORIGINAL ARTICLES: Superior and Basal Segment Lung Cancers in the Lower Lobe Have Different Lymph Node Metastatic Pathways and Prognosis Shun-ichi Watanabe, MD, Kenji Suzuki, MD, and Hisao Asamura, MD

More information

The present staging system for esophageal carcinoma

The present staging system for esophageal carcinoma Esophageal Carcinoma: Depth of Tumor Invasion Is Predictive of Regional Lymph Node Status Thomas W. Rice, MD, Gregory Zuccaro, Jr, MD, David J. Adelstein, MD, Lisa A. Rybicki, MS, Eugene H. Blackstone,

More information

Chen et al. BMC Surgery 2014, 14:110

Chen et al. BMC Surgery 2014, 14:110 Chen et al. BMC Surgery 2014, 14:110 RESEARCH ARTICLE Open Access Cervical lymph node metastasis classified as regional nodal staging in thoracic esophageal squamous cell carcinoma after radical esophagectomy

More information

Esophageal Cancer Staging Essentials: The New TNM Staging System (7th edition) and Clinicoradiologic Implications

Esophageal Cancer Staging Essentials: The New TNM Staging System (7th edition) and Clinicoradiologic Implications Esophageal Cancer Staging Essentials: The New TNM Staging System (7th edition) and Clinicoradiologic Implications Poster No.: E-0060 Congress: ESTI 2012 Type: Scientific Exhibit Authors: K. Lee, T. J.

More information

Chapter 8 Adenocarcinoma

Chapter 8 Adenocarcinoma Page 80 Chapter 8 Adenocarcinoma Overview In Japan, the proportion of squamous cell carcinoma among all cervical cancers has been declining every year. In a recent survey, non-squamous cell carcinoma accounted

More information

Index. Note: Page numbers of article titles are in boldface type.

Index. Note: Page numbers of article titles are in boldface type. Note: Page numbers of article titles are in boldface type. A Adenocarcinoma, pancreatic ductal, laparoscopic distal pancreatectomy for, 61 Adrenal cortical carcinoma, laparoscopic adrenalectomy for, 114

More information

Prognostic Factors for the Survival of Patients with Esophageal Carcinoma in the U.S.

Prognostic Factors for the Survival of Patients with Esophageal Carcinoma in the U.S. 1434 Prognostic Factors for the Survival of Patients with Esophageal Carcinoma in the U.S. The Importance of Tumor Length and Lymph Node Status Mohamad A. Eloubeidi, M.D., M.H.S. 1,2 Renee Desmond, Ph.D.

More information

Endoscopic UltraSound (EUS) Endoscopic Mucosal Resection (EMR) Moishe Liberman Director C.E.T.O.C.

Endoscopic UltraSound (EUS) Endoscopic Mucosal Resection (EMR) Moishe Liberman Director C.E.T.O.C. Endoscopic UltraSound (EUS) Endoscopic Mucosal Resection (EMR) Moishe Liberman Director C.E.T.O.C. Division of Thoracic Surgery Centre Hospitalier de l Université de Montréal Research Grants: Disclosures

More information

Esophageal carcinoma is one of the most tedious

Esophageal carcinoma is one of the most tedious Subcarinal Node Metastasis in Thoracic Esophageal Squamous Cell Carcinoma Jingeng Liu, MD,* YiHu,MD,* Xuan Xie, MD, and Jianhua Fu, MD Department of Thoracic Oncology, Cancer Center, Sun Yat-sen University,

More information

Towards a more personalized approach in the treatment of esophageal cancer focusing on predictive factors in response to chemoradiation Wang, Da

Towards a more personalized approach in the treatment of esophageal cancer focusing on predictive factors in response to chemoradiation Wang, Da University of Groningen Towards a more personalized approach in the treatment of esophageal cancer focusing on predictive factors in response to chemoradiation Wang, Da IMPORTANT NOTE: You are advised

More information

Long-term Follow-up for Patients with Papillary Thyroid Carcinoma Treated as Benign Nodules

Long-term Follow-up for Patients with Papillary Thyroid Carcinoma Treated as Benign Nodules Long-term Follow-up for Patients with Papillary Thyroid Carcinoma Treated as Benign Nodules YASUHIRO ITO, TAKUYA HIGASHIYAMA, YUUKI TAKAMURA, AKIHIRO MIYA, KAORU KOBAYASHI, FUMIO MATSUZUKA, KANJI KUMA

More information

A case of local recurrence and distant metastasis following curative endoscopic submucosal dissection of early gastric cancer

A case of local recurrence and distant metastasis following curative endoscopic submucosal dissection of early gastric cancer Gastric Cancer (2015) 18:188 192 DOI 10.1007/s10120-014-0341-7 CASE REPORT A case of local recurrence and distant metastasis following curative endoscopic submucosal dissection of early gastric cancer

More information

Visceral pleura invasion (VPI) was adopted as a specific

Visceral pleura invasion (VPI) was adopted as a specific ORIGINAL ARTICLE Visceral Pleura Invasion Impact on Non-small Cell Lung Cancer Patient Survival Its Implications for the Forthcoming TNM Staging Based on a Large-Scale Nation-Wide Database Junji Yoshida,

More information

Katsuro Sato. Department of Speech, Language and Hearing Sciences, Niigata University of Health and Welfare, Niigata, Japan

Katsuro Sato. Department of Speech, Language and Hearing Sciences, Niigata University of Health and Welfare, Niigata, Japan Report Niigata Journal of Health and Welfare Vol. 12, No. 1 Retrospective analysis of head and neck cancer cases from the database of the Niigata Prefecture Head and Neck Malignant Tumor Registration Committee

More information

Hiroyuki Tanishima 1*, Masamichi Kimura 1, Toshiji Tominaga 1, Shinji Iwakura 1, Yoshihiko Hoshida 2 and Tetsuya Horiuchi 1

Hiroyuki Tanishima 1*, Masamichi Kimura 1, Toshiji Tominaga 1, Shinji Iwakura 1, Yoshihiko Hoshida 2 and Tetsuya Horiuchi 1 Tanishima et al. Surgical Case Reports (2017) 3:93 DOI 10.1186/s40792-017-0366-3 CASE REPORT Open Access Lateral lymph node metastasis in a patient with T1 upper rectal cancer treated by lateral lymph

More information

Esophageal cancer (EC) is the eighth most common cancer worldwide and the sixth most common cause of cancer-related mortality (Kamangar et al.

Esophageal cancer (EC) is the eighth most common cancer worldwide and the sixth most common cause of cancer-related mortality (Kamangar et al. Arch. Biol. Sci., Belgrade, 65 (3), 821-827, 2013 DOI:10.2298/ABS1303821L DETERMINING THE LYMPH NODE CLINICAL TARGET VOLUME OF UPPER ESOPHAGEAL CARCINOMA WITH COMPUTED TOMOGRAPHY MINGHUAN LI 1, YUHUI LIU

More information

Kawahara, Katsunobu; Tomita, Masao. Citation Acta Medica Nagasakiensia. 1992, 37

Kawahara, Katsunobu; Tomita, Masao. Citation Acta Medica Nagasakiensia. 1992, 37 NAOSITE: Nagasaki University's Ac Title Author(s) TRANSHIATAL ESOPHAGECTOMY FOR CARCI THORACIC ESOPHAGUS Ayabe, Hiroyoshi; Tsuji, Hiroharu; Kawahara, Katsunobu; Tomita, Masao Citation Acta Medica Nagasakiensia.

More information

Tumor location is a risk factor for lymph node metastasis in superficial Barrett s adenocarcinoma

Tumor location is a risk factor for lymph node metastasis in superficial Barrett s adenocarcinoma Tumor location is a risk factor for lymph node metastasis in superficial Barrett s adenocarcinoma Authors Masayoshi Yamada 1,IchiroOda 1,HirohitoTanaka 1, Seiichiro Abe 1, Satoru Nonaka 1, Haruhisa Suzuki

More information

Sentinel Lymph Node Biopsy in Other Tumours: Sentinel Lymph Node Biopsy in Other Tumours. Methodology. Results. Key Questions to Consider

Sentinel Lymph Node Biopsy in Other Tumours: Sentinel Lymph Node Biopsy in Other Tumours. Methodology. Results. Key Questions to Consider Sentinel Lymph Node Biopsy in Other Tumours Dr. Rona Cheifetz Surgical Oncology Update November 24, 2006 Sentinel Lymph Node Biopsy in Other Tumours: An Operation Looking for an Application Dr. Rona Cheifetz

More information

Introduction. Keywords Superficial esophageal cancer ESD Esophagectomy

Introduction. Keywords Superficial esophageal cancer ESD Esophagectomy https://doi.org/10.1007/s00595-018-1650-y ORIGINAL ARTICLE A comparison of the clinical outcomes of esophagectomy and chemoradiotherapy after noncurative endoscopic submucosal dissection for esophageal

More information

Radiation Therapy for Recurrent Esophageal Cancer after Surgery: Clinical Results and Prognostic Factors

Radiation Therapy for Recurrent Esophageal Cancer after Surgery: Clinical Results and Prognostic Factors Radiation Therapy for Recurrent Esophageal Cancer after Surgery: Clinical Results and Prognostic Factors Yoshiyuki Shioyama 1, Katsumasa Nakamura 1, Saiji Ohga 1, Satoshi Nomoto 1, Tomonari Sasaki 1, Toshihiro

More information

Disclosure. Acknowledgement. What is the Best Workup for Rectal Cancer Staging: US/MRI/PET? Rectal cancer imaging. None

Disclosure. Acknowledgement. What is the Best Workup for Rectal Cancer Staging: US/MRI/PET? Rectal cancer imaging. None What is the Best Workup for Rectal Cancer Staging: US/MRI/PET? Zhen Jane Wang, MD Assistant Professor in Residence UC SF Department of Radiology Disclosure None Acknowledgement Hueylan Chern, MD, Department

More information

MUSCLE-INVASIVE AND METASTATIC BLADDER CANCER

MUSCLE-INVASIVE AND METASTATIC BLADDER CANCER MUSCLE-INVASIVE AND METASTATIC BLADDER CANCER (Text update March 2008) A. Stenzl (chairman), N.C. Cowan, M. De Santis, G. Jakse, M. Kuczyk, A.S. Merseburger, M.J. Ribal, A. Sherif, J.A. Witjes Introduction

More information

Parameters Linked to Ten-Year Survival in Japan of Resected Esophageal Carcinoma

Parameters Linked to Ten-Year Survival in Japan of Resected Esophageal Carcinoma Parameters Linked to Ten-Year Survival in Japan of Resected Esophageal Carcinoma Japanese Committee for Registration ofesophageal Carcinoma Cases Chairman: Toshifumi lizuka, M.D.* Members: Kaichi lsono,

More information

MATERIALS AND METHODS Patients

MATERIALS AND METHODS Patients Yonago Acta medica 216;59:232 236 Original Article Usefulness of T-Shaped Gauze for Precise Dissection of Supra-Pancreatic Lymph Nodes and for Reduced Postoperative Pancreatic Fistula in Patients Undergoing

More information

Tumours of the Oesophagus & Gastro-Oesophageal Junction Histopathology Reporting Proforma

Tumours of the Oesophagus & Gastro-Oesophageal Junction Histopathology Reporting Proforma Tumours of the Oesophagus & Gastro-Oesophageal Junction Histopathology Reporting Proforma Mandatory questions (i.e. protocol standards) are in bold (e.g. S1.01). S1.01 Identification Family name Given

More information

HHS Public Access Author manuscript Clin Gastroenterol Hepatol. Author manuscript; available in PMC 2017 March 01.

HHS Public Access Author manuscript Clin Gastroenterol Hepatol. Author manuscript; available in PMC 2017 March 01. A Model Based on Pathologic Features of Superficial Esophageal Adenocarcinoma Complements Clinical Node Staging in Determining Risk of Metastasis to Lymph Nodes Jon M. Davison, MD 1, Michael S. Landau,

More information

North of Scotland Cancer Network Clinical Management Guideline for Non Small Cell Lung Cancer

North of Scotland Cancer Network Clinical Management Guideline for Non Small Cell Lung Cancer THIS DOCUMENT IS North of Scotland Cancer Network Clinical Management Guideline for Non Small Cell Lung Cancer [Based on WOSCAN NSCLC CMG with further extensive consultation within NOSCAN] UNCONTROLLED

More information

Esophageal carcinoma is a significant worldwide health

Esophageal carcinoma is a significant worldwide health Original Article Clinical Staging of Patients with Early Esophageal Adenocarcinoma Does FDG-PET/CT Have a Role? Sonia L. Betancourt Cuellar, MD,* Brett W. Carter, MD,* Homer A. Macapinlac, MD, Jaffer A.

More information

Pattern of lymphatic spread in thoracic esophageal squamous cell carcinoma: A single-institution experience

Pattern of lymphatic spread in thoracic esophageal squamous cell carcinoma: A single-institution experience GENERAL THORACIC SURGERY Pattern of lymphatic spread in thoracic esophageal squamous cell carcinoma: A single-institution experience Bin Li, MD, a,b Haiquan Chen, MD, a,b Jiaqing Xiang, MD, a,b Yawei Zhang,

More information

Early and long term outcomes of endoscopic submucosal dissection for early gastric cancer in a large patient series

Early and long term outcomes of endoscopic submucosal dissection for early gastric cancer in a large patient series 594 Early and long term outcomes of endoscopic submucosal dissection for early gastric cancer in a large patient series KEN OHNITA 1, HAJIME ISOMOTO 1, SABURO SHIKUWA 2, HIROYUKI YAJIMA 1, HITOMI MINAMI

More information

Key words: carcinoma of hypopharynx, carcinoma of cervical esophagus, esophagectomy without thoracotomy, synchronous double cancer of hypopharynx,

Key words: carcinoma of hypopharynx, carcinoma of cervical esophagus, esophagectomy without thoracotomy, synchronous double cancer of hypopharynx, Key words: carcinoma of hypopharynx, carcinoma of cervical esophagus, esophagectomy without thoracotomy, synchronous double cancer of hypopharynx, radiotherapy f ser age site hisrorogy ;?::t-ti"l"r. ffj$o.rr"",

More information

Lymph node dissection for lung cancer is both an old

Lymph node dissection for lung cancer is both an old LOBE-SPECIFIC EXTENT OF SYSTEMATIC LYMPH NODE DISSECTION FOR NON SMALL CELL LUNG CARCINOMAS ACCORDING TO A RETROSPECTIVE STUDY OF METASTASIS AND PROGNOSIS Hisao Asamura, MD Haruhiko Nakayama, MD Haruhiko

More information

Aliu Sanni MD SUNY Downstate Medical Center August 16, 2012

Aliu Sanni MD SUNY Downstate Medical Center August 16, 2012 Aliu Sanni MD SUNY Downstate Medical Center August 16, 2012 Case Presentation 60yr old AAF with PMH of CAD s/p PCI 1983, CVA, GERD, HTN presented with retrosternal chest pain on 06/12 Associated dysphagia

More information

Characteristics and prognostic factors of synchronous multiple primary esophageal carcinoma: A report of 52 cases

Characteristics and prognostic factors of synchronous multiple primary esophageal carcinoma: A report of 52 cases Thoracic Cancer ISSN 1759-7706 ORIGINAL ARTICLE Characteristics and prognostic factors of synchronous multiple primary esophageal carcinoma: A report of 52 cases Mei Li & Zhi-xiong Lin Department of Radiation

More information

Metachronous Esophageal Cancer and Colon Cancer Treated by Endoscopic Mucosal Resection

Metachronous Esophageal Cancer and Colon Cancer Treated by Endoscopic Mucosal Resection CASE REPORT Metachronous Esophageal Cancer and Colon Cancer Treated by Endoscopic Mucosal Resection Chun-Chao Chang, Chia-Lang Fang, Horng-Yuan Lou, Ching-Ruey Hsieh, Sheng-Hsuan Chen* Most cases of esophageal

More information

Surgical Management of Esophageal Cancer Sophia L Fu, MD Long Island College Hospital SUNY Downstate Medical Center, Brooklyn, NY 03/27/2009 Questions The T and N status of esophageal carcinoma is most

More information