Immune Checkpoints in the Tumor Environment:

Size: px
Start display at page:

Download "Immune Checkpoints in the Tumor Environment:"

Transcription

1 Immune Checkpoints in the Tumor Environment: Novel Targets and the Clinical Promise of Combined Immunotherapies Monday, 28 October (AM) Parkside Ballroom B, Convention Centre Level 1 Phosphatidylserine (PS)-Mediated Immune Suppression in Tumors Support for this educational activity is provided by Peregrine Pharmaceuticals, Inc.

2 Chairman Welcome Dear Colleagues, On behalf of my distinguished faculty and Peregrine Pharmaceuticals, Inc., it is my pleasure to welcome you to what promises to be an interesting breakfast discussion at the 15 th Annual World Conference on Lung Cancer. The program titled Immune Checkpoints in the Tumor Environment: Novel Targets and the Clinical Promise of Combined Immunotherapies will highlight the discoveries that have been made about novel immune checkpoints, including PD-1, CTLA-4 and related molecules including exposed phosphatidylserine (PS) in the tumor environment. We will explore strategies to utilize this knowledge for optimizing patient outcomes. I believe that given the growing interest in the potential applications of immunotherapy in cancer treatments as well as the management of lung cancer, you will find this program quite interesting. Sincerely, Scott J. Antonia, MD, PhD H. Lee Moffitt Cancer Center Tampa, Florida

3 Program Scott J. Antonia, MD, PhD, H. Lee Moffitt Cancer Center (Symposium Chair and Moderator) - Introduction Dmitry L. Gabrilovich, MD, PhD, The Wistar Institute Myeloid-Derived Suppressor Cells as Negative Regulator of Immune Responses in Cancer Rolf A. Brekken, PhD, University of Texas Southwestern Engagement of Phosphatidylserine (PS) by PS-Targeting Antibodies Blocks a Global Immunosuppressive Checkpoint in the Tumor Microenvironment Inducing Multiple Downstream Anti-Tumor Response Mechanisms David E. Gerber, MD, University of Texas Southwestern Clinical Experience and Prospects with Checkpoint Immunotherapy in Lung Cancer

4 Biographies Scott J. Antonia, MD, PhD Department Chair and Program Leader, Thoracic Oncology and Program Leader of Immunology Program, H. Lee Moffitt Cancer Center, Tampa Florida Professor of Oncology, University of South Florida College of Medicine, Tampa, Florida Dr. Antonia is currently the Department Chair and Program Leader of the Thoracic Oncology Department, Associate Professor in the Department of Interdisciplinary Oncology and Program Leader of the Immunology Program at the H. Lee Moffitt Cancer Center and Research Institute in Tampa, Florida. He is also a Professor of Oncology at the University of South Florida College of Medicine in Tampa. Prior to being named chair of Thoracic Oncology in 2010, he was associate chairman of the Sarcoma Department. He joined the Moffitt Cancer Center in Dr. Antonia received his M.D. and his Ph.D. in Immunology from the University of Connecticut Health Center in Farmington, Connecticut. In addition, he completed an internal medicine residency at Yale University School of Medicine and pursued additional training at Yale through a medical oncology fellowship and post-doctoral fellowship in Immunobiology. Dr. Antonia s work focuses on translational research. Using his molecular biology and cellular background in the development of immunotherapeutic strategies for the treatment of cancer patients, he has developed strategies designed to thwart the immunosuppressive mechanisms used by tumors to evade T-cell mediated rejection. His clinical interests focus on immunotherapy and immunobiology, in particular, gene-modified tumor cell vaccine trials at both pre-clinical and clinical stages. He has designed and conducted numerous cutting-edge studies with novel immunotherapeutics and has two patents for technology he has developed. He has been awarded a K24 grant from the National Cancer Institute to support his clinical research and is the principal investigator for a Thoracic SPORE project. Dr. Antonia is also conducting several ongoing investigator-initiated clinical trials testing novel tumor vaccines, and tumor vaccine augmentation strategies for the treatment of various cancers. Dr. Antonia also serves as chairman of Moffitt s Scientific Review Committee and medical director of the Tumor Vaccine Production Facility at Moffitt. He was named the Moffitt Physician of the Year in 2005 and Mentor of the Year in Dr. Antonia has published papers in several peer-reviewed journals, including Science, Clinical Cancer Research, Current Opinions in Oncology, and Cancer Research.

5 Dmitry L. Gabrilovich, MD, PhD Christopher M. Davis Professor in Cancer Research, Program Leader, Translational Tumor Immunology, The Wistar Institute, Philadelphia, Pennsylvania Dr. Gabrilovich is currently the Christopher M. Davis Professor in Cancer Research and Program Leader, Translational Tumor Immunology at The Wistar Institute, Philadelphia, Pennsylvania. The Wistar Institute is the nation s first independent institution devoted to medical research and training and has been designated a National Cancer Institute Cancer Center in basic research. Prior to joining Wistar, Dr. Gabrilovich was the Robert Rothman Endowed Chair in Cancer Research and Head, Section of Dendritic Cell Biology at the Moffitt Cancer Center in the Department of Immunology and a Professor of Oncologic Sciences and Molecular Medicine at the University of South Florida. Prior to this, Dr. Gabrilovich was a Research Fellow at the Imperial College in London, United Kingdom and at the University of Texas Southwestern Medical Center in Dallas, Texas. Dr. Gabrilovich earned his MD from Kabardino-Balkarian State University Medical School in Nalchik, Russia and his Ph.D. in Immunology from the Central Institute of Epidemiology in Moscow, Russia. Dr. Gabrilovich s research has been focused on abnormalities in the function of various myeloid cells, which play a major role in regulation of immune responses. One group of cells is professional antigen-presenting cells, dendritic cells (DC). These cells are responsible for induction of the anti-tumor immune response. He was one of the first investigators who demonstrated the defects in the function of dendritic cells in cancer. Dr. Gabrilovich and his team have found that defects in differentiation of DC are associated with accumulation of immature myeloid cells in tumorbearing animals and patients with cancer. Under normal conditions, these cells represent an intermediate stage of myeloid cell differentiation. In cancer, however, they lose the ability to differentiate into mature myeloid cells, including granulocytes, DC, and macrophages. They become functionally defective and acquire the ability to suppress immune responses. Dr. Gabrilovich together with investigators from other institutions coined the term myeloid-derived suppressor cells (MDSC) which is now widely used to characterize these cells. He is one of the pioneers in discovering that murine and human MDSC have a significant role in the suppression of anti-tumor immune response. Since 2007, when the term was introduced by Dr. Gabrilovich and colleagues, more than 600 papers studying these cells were published. Dr. Gabrilovich s lab is focused on understanding the mechanisms of tumor-associated immunosuppression as well as on the development of new effective cancer immunotherapeutics. His work explores different aspects of immature myeloid cell biology in cancer. Specifically, how cellular and molecular mechanisms of T-cell suppression and tolerance are induced as a result of abnormal differentiation of myeloid cells and abnormal DC function. Their main focus is on the role of reactive oxygen species and peroxynitrite in regulation of T-cell function. His work demonstrates that reactive oxygen species produced by immature myeloid cells in vitro and in tumor-bearing animals in the presence of tumor-derived soluble factors are substantial contributors to the immunosuppression mediated by these cells in cancer.

6 Rolf A. Brekken, PhD Effie Marie Cain Research Scholar in Angiogenesis Research and Associate Professor, Hamon Center for Therapeutic Oncology, University of Texas Southwest Medical Center, Dallas, Texas Dr. Brekken is the Effie Marie Cain Research Scholar in Angiogenesis Research and an Associate Professor, in the Departments of Surgery and Pharmacology and a Principal Investigator in the Hamon Center for Therapeutic Oncology Research, University of Texas Southwest Medical Center in Dallas, Texas. He is a member of the faculty of the school s Integrative Biology and Cancer Biology Graduate programs in the UT Southwestern Graduate School of Biomedical Sciences. Dr. Brekken received his Bachelor of Arts degree from Luther College in Decorah, Iowa and his PhD (Cell and Molecular Biology) from UT Southwestern Graduate School of Biomedical Sciences. His postdoctoral fellowship was conducted in the Department of Vascular Biology at the Hope Heart Institute in Seattle, Washington where he studied how the extracellular matrix contributes to vascular function in and growth of tumors. Dr. Brekken s research interests include angiogenesis and extracellular matrix remodeling in tumors and the development and evaluation of novel therapies for cancer. His laboratory is particularly interested in the biology of novel therapies and how the intricacies of the tumor microenvironment affect therapeutic efficacy. He is an author on over 100 peer reviewed scientific papers and is a senior editor of Cancer Research. David E. Gerber, MD Associate Professor, Internal Medicine, Division Hematology-Oncology University of Texas Southwest Medical Center, Dallas, Texas Dr. Gerber is currently an Associate Professor of Internal Medicine in the Hematology-Oncology Division at the University of Texas Southwestern Medical Center in Dallas, Texas where he joined the faculty in Dr. Gerber earned his M.D. from Cornell University Medical College in New York, New York, and completed his internship and residency in Internal Medicine at the University of Texas Southwestern Medical Center in Dallas, Texas. He completed his fellowship in medical oncology at Johns Hopkins University School of Medicine in Baltimore, Maryland. Dr. Gerber is board certified in Internal Medicine and Medical Oncology. Dr. Gerber research interests are focused particularly in lung cancer, which have generated over 40 peer-reviewed publications. He has also authored two books and 12 book chapters on this topic with his studies contributing to invitations to lecture both nationally and internationally. Within the Harold C. Simmons Cancer Center at University of Texas Southwestern, Dr. Gerber serves as Co-Leader of the Experimental Therapeutics Scientific Program which aims to identify novel targets for tumor targeting, perform laboratory testing of new treatment strategies, and develop new biomarkers and clinical trials. He is also Co-Director of the Lung Cancer clinical research team. On an international level, he serves on American Society of Clinical Oncology (ASCO) and International Association for the Study of Lung Cancer (IASLC) committees related to lung cancer research and treatment; he also serves on the editorial board of the Journal of Clinical Oncology, and as a grant reviewer for the United States Department of Defense and the American Cancer Society.

7 Immunosuppressive signals from PS help tumors evade immune surveillance. Antibody-mediated Phosphatidylserine (PS) blockade overrides immunosuppressive signaling. Phospholipids are distributed asymmetrically in the plasma membrane of most normal eukaryotic cells. Unlike neutral phospholipids that are distributed randomly across the bilayer membrane, phosphatidylserine (PS) is localized predominantly in the inner membrane leaflet. The asymmetric distribution of PS is maintained actively by an ATP-dependent aminophospholipid translocase. During apoptosis, PS is externalized to the outer plasma membrane leaflet where it functions as an eat me signal that facilitates the recognition and clearance of dying cells. PS-dependent engulfment of apoptotic cells triggers a series of events that leads to the generation of potent immunosuppressive signals associated with Myeloid Derived Suppressor Cells (MDSCs) and M2 macrophages that quell any potential autoimmune responses. Thus, PS exposure represents an evolutionarily conserved mechanism of immune suppression. Tumors have hijacked this biology such that exposure of PS in the tumor microenvironment is critical in maintaining the immunosuppressive state of tumors. Externalized PS is abundant in the tumor microenvironment : it is found on tumor vascular endothelial cells, on tumor-derived microvesicles, and constitutively on some tumor cells. Moreover, the exposure of PS is increased significantly on tumor cells in response to chemotherapy and radiotherapy. Externalized PS interacts with PS receptors on immune cells where it actively promotes expansion of immunosuppressive cells that enhance tumor progression and prevent induction of adaptive tumor immunity. Based on these observations, we propose that PS exposure is a global immune checkpoint that is exploited by successful tumor for growth and progression. To explore the possibility of reversing the immunosuppressive effects of exposed PS, we raised a family of PS-targeting antibodies that bind or target PS with high affinity. For example, bavituximab, a chimeric PS targeting antibody is currently in multiple clinical trials, with the initiation of a Phase III trial in non-small cell lung cancer underway. Data obtained in pre-clinical tumor models indicate that antibody mediated PS blockade reactivates tumor immunity on multiple levels. It repolarizes tumor associated macrophages from an immunosuppressive to a tumoricidal phenotype, it decreases the presence of immunosuppressive MDSCs and promotes their differentiation, it promotes dendritic cell maturation into functional antigen presenting cells, and induces tumor specific cytotoxic T-cell immunity. Thus, antibody mediated PS blockade promotes innate and adaptive tumor immunity. Impressive anti-tumor effects have been obtained in cancer patients by blockade of immune checkpoints (e.g., antibodies specific for PD-1, PD-L1, and CTLA-4). However, only a limited number of patients benefit from these therapies. Mechanistic studies indicate that blockade of these immune checkpoints are most effective when there is a de novo or pre-existing antitumor immune response. Unfortunately, pre-existing tumor specific immune activity is limited in cancer patients because of the exposure of PS in the tumor microenvironment. Our results in animal models indicate that antibody-mediated PS blockade with bavituximab reverses PS-mediated immunosuppression and initiates therapeutically effective adaptive antitumor immunity. Thus, treatment with bavituximab in combination with blockade of downstream immune checkpoints could potentially result in robust and long-lasting antitumor immunity that significantly improves clinical outcomes. For more information please see Yin et al 2013 Cancer Immunology Research 1: doi: /

8

Posters and Presentations

Posters and Presentations Posters and Presentations June 2017: American Society of Clinical Oncology (ASCO) Annual - Preliminary Correlative Analysis of PD-L1 expression from the SUNRISE Study. View April 2017: American Association

More information

TITLE: Targeting hosphatidylserince for adioimmunotherapy of east ancer rain etastasis. CONTRACTING ORGANIZATION: U Southwestern Center

TITLE: Targeting hosphatidylserince for adioimmunotherapy of east ancer rain etastasis. CONTRACTING ORGANIZATION: U Southwestern Center Award Number: W81XWH-12-1-0316 TITLE: Targeting hosphatidylserince for adioimmunotherapy of east ancer rain etastasis PRINCIPAL INVESTIGATOR: Rolf A. Brekken CONTRACTING ORGANIZATION: U Southwestern Center

More information

JAY A. NELSON, PH.D. Executive Director and Vice President

JAY A. NELSON, PH.D. Executive Director and Vice President JAY A. NELSON, PH.D. Executive Director and Vice President TRANSLATING RESEARCH INTO HEALTH Jay A. Nelson, Ph.D., is the founder and Executive Director of Vaccine & Gene Therapy Institute of Florida (VGTI-FL)

More information

Hosts. New Treatments for Cancer

Hosts. New Treatments for Cancer Hosts Anees MD Associate Professor of Surgical Oncology Francine Foss MD Professor of Medical Oncology New Treatments for Cancer Guest Expert: Lieping Chen, MD, PhD United Technologies Corporation Professor

More information

Soft Tissue Sarcoma: What is best practice?

Soft Tissue Sarcoma: What is best practice? Soft Tissue Sarcoma: What is best practice? 18:30-19:45, Thursday 10th November 2016 Opala Rooms I, II and III, 1st Floor, Corinthia Hotel Lisbon Chaired by Alessandro Gronchi With Angelo Paolo Dei Tos,

More information

Nobel Prize in Physiology or Medicine 2018

Nobel Prize in Physiology or Medicine 2018 Nobel Prize in Physiology or Medicine 2018 Arunika Mukhopadhaya The Nobel Prize in Physiology or Medicine for the year 2018 was awarded to James P Allison of the United States and Tasuku Honjo of Japan

More information

Immune Checkpoints. PD Dr med. Alessandra Curioni-Fontecedro Department of Hematology and Oncology Cancer Center Zurich University Hospital Zurich

Immune Checkpoints. PD Dr med. Alessandra Curioni-Fontecedro Department of Hematology and Oncology Cancer Center Zurich University Hospital Zurich Immune Checkpoints PD Dr med. Alessandra Curioni-Fontecedro Department of Hematology and Oncology Cancer Center Zurich University Hospital Zurich Activation of T cells requires co-stimulation Science 3

More information

$884,000 to Melanoma Research

$884,000 to Melanoma Research $884,000 to Melanoma Research EVERY DOLLAR IN GOES OUT! The Miller family funds all event and foundation costs so that every dollar raised goes directly to research and is 100% tax deductible. $734,000

More information

IMMUNOTHERAPY FOR CANCER A NEW HORIZON. Ekaterini Boleti MD, PhD, FRCP Consultant in Medical Oncology Royal Free London NHS Foundation Trust

IMMUNOTHERAPY FOR CANCER A NEW HORIZON. Ekaterini Boleti MD, PhD, FRCP Consultant in Medical Oncology Royal Free London NHS Foundation Trust IMMUNOTHERAPY FOR CANCER A NEW HORIZON Ekaterini Boleti MD, PhD, FRCP Consultant in Medical Oncology Royal Free London NHS Foundation Trust ASCO Names Advance of the Year: Cancer Immunotherapy No recent

More information

Lecture outline. Immunological tolerance and immune regulation. Central and peripheral tolerance. Inhibitory receptors of T cells. Regulatory T cells

Lecture outline. Immunological tolerance and immune regulation. Central and peripheral tolerance. Inhibitory receptors of T cells. Regulatory T cells 1 Immunological tolerance and immune regulation Abul K. Abbas UCSF 2 Lecture outline Central and peripheral tolerance Inhibitory receptors of T cells Regulatory T cells 1 The immunological equilibrium:

More information

Discover the PD-1 pathway and its role in cancer 105/15 -ONCO- 07/15

Discover the PD-1 pathway and its role in cancer 105/15 -ONCO- 07/15 Discover the PD-1 pathway and its role in cancer 105/15 -ONCO- 07/15 Immunology in cancer The role of immunology in cancer Evolving knowledge of the immune system has provided a better understanding of

More information

PENN TRANSPLANT SURGERY FACULTY

PENN TRANSPLANT SURGERY FACULTY Abraham Shaked, MD, PhD, is the Eldrige L. Eliason Professor of Surgery, and Director of the Penn Transplant Institute. Dr. Shaked received his MD degree from the Hebrew University in Israel and completed

More information

Evolution of the individualized treatment landscape for advanced NSCLC

Evolution of the individualized treatment landscape for advanced NSCLC IASLC Asia Pacific Lung Cancer Conference (APLCC 2016) 13-15 May 2016, Chiang Mai, Thailand Evolution of the individualized treatment landscape for advanced NSCLC Chaired by Tony Mok Empress Grand Hall,

More information

TITLE: Targeting Phosphatidylserine for Radioimmunotherapy of Breast Cancer Brain Metastasis

TITLE: Targeting Phosphatidylserine for Radioimmunotherapy of Breast Cancer Brain Metastasis Award Number: W81XWH-12-1-0316 TITLE: Targeting Phosphatidylserine for Radioimmunotherapy of Breast Cancer Brain Metastasis PRINCIPAL INVESTIGATOR: Rolf A. Brekken CONTRACTING ORGANIZATION: Univeristy

More information

Engineered Immune Cells for Cancer Therapy : Current Status and Prospects

Engineered Immune Cells for Cancer Therapy : Current Status and Prospects When Engineering Meets Immunology Engineered Immune Cells for Cancer Therapy : Current Status and Prospects Yong Taik Lim, Ph.D. Nanomedical Systems Laboratory (http://www.nanomedicalsystems.org) SKKU

More information

HEMATOLOGY AND ONCOLOGY

HEMATOLOGY AND ONCOLOGY x THE POWER OF HEMATOLOGY AND ONCOLOGY Experts. Experience. Execution. A Deeper Dive into Hematology and Oncology Medpace supports our sponsors who are advancing new anti-cancer therapies by providing

More information

Objectives. Abbas Chapter 11: Immunological Tolerance. Question 1. Question 2. Question 3. Definitions

Objectives. Abbas Chapter 11: Immunological Tolerance. Question 1. Question 2. Question 3. Definitions Objectives Abbas Chapter 11: Immunological Tolerance Christina Ciaccio, MD Children s Mercy Hospitals and Clinics February 1, 2010 To introduce the concept of immunologic tolerance To understand what factors

More information

UC Davis Comparative Oncology Program and Current Research

UC Davis Comparative Oncology Program and Current Research UC Davis Comparative Oncology Program and Current Research Michael S. Kent, DVM, DACVIM (Oncology), DACVIM (Radiation Oncology) Professor Radiation Oncology Director, Center for Companion Animal Health

More information

Jeff T. Hutchins, PhD Vice President, Pre-Clinical Research Peregrine Pharmaceuticals, Inc. March 25, 2015

Jeff T. Hutchins, PhD Vice President, Pre-Clinical Research Peregrine Pharmaceuticals, Inc. March 25, 2015 Expansion and Activation of T-cells via the Targeting of the Immunosuppressive Ligand Phosphatidylserine: Combination Strategy with Other Checkpoint Inhibitors Jeff T. Hutchins, PhD Vice President, Pre-Clinical

More information

Ohio State Urology Update. New fellowship offering Research focus on pediatric UTIs Men s Sexual Health adds new service

Ohio State Urology Update. New fellowship offering Research focus on pediatric UTIs Men s Sexual Health adds new service Ohio State Urology Update New fellowship offering Research focus on pediatric UTIs Men s Sexual Health adds new service 3,185 SURGICAL CASES 2 FELLOWS Ohio State Urology by the Numbers OFFICE AND OUTPATIENT

More information

Intensive Board Review Course. Faculty. August 9-11, 2018 Hyatt Regency Minneapolis Minneapolis, MN

Intensive Board Review Course. Faculty. August 9-11, 2018 Hyatt Regency Minneapolis Minneapolis, MN Intensive Board Review Course Faculty August 9-11, 2018 Hyatt Regency Minneapolis Minneapolis, MN Janet Bull, MD MBA FAAHPM Dr. Bull is the Chief Medical Officer at Four Seasons Compassion and holds a

More information

Dr Graeme Suthers: The genetic basis of cancer

Dr Graeme Suthers: The genetic basis of cancer Dr Graeme Suthers: The genetic basis of cancer Dr Suthers is the head of the Familial Cancer Unit at the Women s and Children s hospital. He will begin the evening with an introduction to cancer and its

More information

Tumor Immunology: A Primer

Tumor Immunology: A Primer Transcript Details This is a transcript of a continuing medical education (CME) activity accessible on the ReachMD network. Additional media formats for the activity and full activity details (including

More information

Officers and Board of Directors Slate for 2016

Officers and Board of Directors Slate for 2016 Officers and Board of Directors Slate for 2016 The Nominating Committee oversaw a very competitive nominations process in 2015, with 16 nominations for seven elected positions. The committee has recommended

More information

BASIC MECHANISM OF TUMOR IMMUNE SUPPRESSION

BASIC MECHANISM OF TUMOR IMMUNE SUPPRESSION BASIC MECHANISM OF TUMOR IMMUNE SUPPRESSION Zihai Li, M.D., Ph.D. Leader, Cancer Immunology Program Hollings Cancer Center Medical University of South Carolina (MUSC) DISCLOSURE GOALS Understand that immune

More information

Clinical Trials: Advanced or Metastatic Bladder Cancer Wednesday June 22 nd, 2016 Part III: Question and Answer

Clinical Trials: Advanced or Metastatic Bladder Cancer Wednesday June 22 nd, 2016 Part III: Question and Answer Clinical Trials: Advanced or Metastatic Bladder Cancer Wednesday June 22 nd, 2016 Part III: Question and Answer Questions Answered by Andrea Apolo, MD is a Lasker Clinical Research Scholar and tenure-track

More information

Cancer Research Experience Program. Opportunities for Howard University Students Program Year

Cancer Research Experience Program. Opportunities for Howard University Students Program Year R O S W E L L PA R K C A N C E R I N S T I T U T E S Cancer Research Experience Program Opportunities for Howard University Students 2017 Program Year THE ROSWELL PARK/HOWARD UNIVERSITY CANCER SCHOLARS

More information

Delivering Innovative and High Quality Biopharmaceutical Products to Improve Patient Lives ANNUAL MEETING OF STOCKHOLDERS

Delivering Innovative and High Quality Biopharmaceutical Products to Improve Patient Lives ANNUAL MEETING OF STOCKHOLDERS Delivering Innovative and High Quality Biopharmaceutical Products to Improve Patient Lives ANNUAL MEETING OF STOCKHOLDERS October 13, 2016 Safe Harbor Statement During the course of this presentation,

More information

Diversity Clinical Research Workshop Invited Faculty

Diversity Clinical Research Workshop Invited Faculty Diversity Clinical Research Workshop Invited Faculty Alex A. Adjei, MD, PhD, FACP Professor and Chair, Department of Medicine Senior Vice President of Clinical Research The Katherine Anne Gioia Chair in

More information

Parallels between cancer and infectious disease

Parallels between cancer and infectious disease Washington University School of Medicine Digital Commons@Becker Open Access Publications 2014 Parallels between cancer and infectious disease Richard S. Hotchkiss Washington University School of Medicine

More information

Immune Checkpoint Inhibitors: The New Breakout Stars in Cancer Treatment

Immune Checkpoint Inhibitors: The New Breakout Stars in Cancer Treatment Immune Checkpoint Inhibitors: The New Breakout Stars in Cancer Treatment 1 Introductions Peter Langecker, MD, PhD Executive Medical Director, Global Oncology Clinipace Worldwide Mark Shapiro Vice President

More information

Immunotherapy: The Newest Treatment Route

Immunotherapy: The Newest Treatment Route Immunotherapy: The Newest Treatment Route IWMF Patient Forum, Phoenix, AZ Madhav Dhodapkar, MD Professor of Medicine and Immunobiology Chief, Section of Hematology Yale University or the Oldest William

More information

ALBERTA PRINCIPAL INVESTIGATORS

ALBERTA PRINCIPAL INVESTIGATORS ALBERTA PRINCIPAL INVESTIGATORS Dr. Gregory Cairncross is Head of the Department of Clinical Neurosciences at the University of Calgary and holder of the Alberta Cancer Foundation Chair in Brain Tumor

More information

Immunotherapy Concept Turned Reality

Immunotherapy Concept Turned Reality Authored by: Jennifer Dolan Fox, PhD VirtualScopics Inc. jennifer_fox@virtualscopics.com +1 585 249 6231 Immunotherapy Concept Turned Reality Introduction While using the body s own immune system as a

More information

Darwinian selection and Newtonian physics wrapped up in systems biology

Darwinian selection and Newtonian physics wrapped up in systems biology Darwinian selection and Newtonian physics wrapped up in systems biology Concept published in 1957* by Macfarland Burnet (1960 Nobel Laureate for the theory of induced immune tolerance, leading to solid

More information

Translational Cardiac Stem Cell Program ( TCSCP )

Translational Cardiac Stem Cell Program ( TCSCP ) Translational Cardiac Stem Cell Program ( TCSCP ) 2017 Developing Revolutionary Treatments for Multiple Diseases Dr. Yerem founded the TCSCP in 2003 to develop revolutionary treatments for life threatening

More information

ABBVIE VENTURES VISION. Drive strategic returns to AbbVie as a key constituent of overall corporate strategy

ABBVIE VENTURES VISION. Drive strategic returns to AbbVie as a key constituent of overall corporate strategy ABBVIE VENTURES ABBVIE VENTURES VISION Drive strategic returns to AbbVie as a key constituent of overall corporate strategy Early access to external innovation with a long-term horizon to generate meaningful

More information

Tumor Microenvironment and Immune Suppression

Tumor Microenvironment and Immune Suppression Tumor Microenvironment and Immune Suppression Hassane M. Zarour,, MD Department of Medicine, Division of Hematology-Oncology, University of Pittsburgh Cancer Institute Hallmarks of Cancer: The Next Generation

More information

Syndax Announces Updated Results from Phase 2 ENCORE 601 Trial of Entinostat in Combination with KEYTRUDA (pembrolizumab)

Syndax Announces Updated Results from Phase 2 ENCORE 601 Trial of Entinostat in Combination with KEYTRUDA (pembrolizumab) Syndax Announces Updated Results from Phase 2 ENCORE 601 Trial of Entinostat in Combination with KEYTRUDA (pembrolizumab) Ongoing ENCORE 601 biomarker analyses suggest enhanced clinical benefit in subpopulation

More information

Scott Abrams, Ph.D. Professor of Oncology, x4375 Kuby Immunology SEVENTH EDITION

Scott Abrams, Ph.D. Professor of Oncology, x4375 Kuby Immunology SEVENTH EDITION Scott Abrams, Ph.D. Professor of Oncology, x4375 scott.abrams@roswellpark.org Kuby Immunology SEVENTH EDITION CHAPTER 13 Effector Responses: Cell- and Antibody-Mediated Immunity Copyright 2013 by W. H.

More information

Highlights from AACR 2015: The Emerging Potential of Immunotherapeutic Approaches in Non-Small Cell Lung Cancer

Highlights from AACR 2015: The Emerging Potential of Immunotherapeutic Approaches in Non-Small Cell Lung Cancer Transcript Details This is a transcript of a continuing medical education (CME) activity accessible on the ReachMD network. Additional media formats for the activity and full activity details (including

More information

Antibody-Drug Conjugates in Glioblastoma Multiforme: Finding Ways Forward

Antibody-Drug Conjugates in Glioblastoma Multiforme: Finding Ways Forward Transcript Details This is a transcript of a continuing medical education (CME) activity accessible on the ReachMD network. Additional media formats for the activity and full activity details (including

More information

Investigating Plinabulin as Immune-Modifying Therapy for Non-Small Cell Lung Cancer (NSCLC)

Investigating Plinabulin as Immune-Modifying Therapy for Non-Small Cell Lung Cancer (NSCLC) Transcript Details This is a transcript of an educational program accessible on the ReachMD network. Details about the program and additional media formats for the program are accessible by visiting: https://reachmd.com/programs/project-oncology/beyondspring-birnholzmita/9543/

More information

Jason Luke, MD, FACP Assistant Professor of Medicine University of Chicago, USA BRIEF INTRODUCTION

Jason Luke, MD, FACP Assistant Professor of Medicine University of Chicago, USA BRIEF INTRODUCTION SPEAKERS BIOGRAPHY Jason Luke, MD, FACP Assistant Professor of Medicine University of Chicago, USA Jason Luke, MD, is an Assistant Professor of Medicine at University of Chicago where he specializes in

More information

CAR T Cell Therapies Workshop

CAR T Cell Therapies Workshop CAR T Cell Therapies Workshop May 15, 2018 Hilton Chicago Continental B Chicago Table of Contents CAR T Cell Therapies Workshop Supporters... p 2 Committee Listing... p 3 Faculty Listing... p 3 Faculty

More information

Neurofibromatosis (NF) Center

Neurofibromatosis (NF) Center Washington University Neurofibromatosis (NF) Center THE NF CENTER: EXCEPTIONAL CARE THROUGH GROUNDBREAKING RESEARCH An international leader in research and treatment of neurofibromatosis (NF), the Washington

More information

Making a Difference. Highest quality care. Education. Research. Innovation. OUR MISSION:

Making a Difference. Highest quality care. Education. Research. Innovation. OUR MISSION: Making a Difference Highest quality care. Education. Research. Innovation. OUR MISSION: To deliver world-class care on a daily basis to our patients using the most advanced technologies available. To conduct

More information

CAR-T Cell Therapy: A Breakthrough Treatment for Fighting Cancer

CAR-T Cell Therapy: A Breakthrough Treatment for Fighting Cancer Transcript Details This is a transcript of an educational program accessible on the ReachMD network. Details about the program and additional media formats for the program are accessible by visiting: https://reachmd.com/programs/medical-breakthroughs-from-penn-medicine/car-t-cell-therapy-abreakthrough-treatment-for-fighting-cancer/9859/

More information

For Immediate Release 15 November 2012

For Immediate Release 15 November 2012 For Immediate Release 15 November 2012 ImmuPharma presents Lupuzor's TM Phase IIb data at leading medical congress, the 2012 American College of Rheumatology Meeting, Washington, D.C. London Analyst Meeting

More information

Israel Makov President and Chief Executive Officer Teva

Israel Makov President and Chief Executive Officer Teva Israel Makov President and Chief Executive Officer Israel Makov has been the President and Chief Executive Officer of since April 2002. Previously he served as 's Chief Operating Officer from January 1,

More information

Strategic intervention to enhance/suppress the immune response Examples: Checkpoint blockade Chimeric Antigen Receptors...Bispecific antibodies

Strategic intervention to enhance/suppress the immune response Examples: Checkpoint blockade Chimeric Antigen Receptors...Bispecific antibodies Strategic intervention to enhance/suppress the immune response Examples: Checkpoint blockade Chimeric Antigen Receptors...Bispecific antibodies After decades of investigation establishing principles in

More information

5% of patients with genetic immunodeficiency develop a cancer during their lifetime (200x)

5% of patients with genetic immunodeficiency develop a cancer during their lifetime (200x) Immune surveillance 5% of patients with genetic immunodeficiency develop a cancer during their lifetime (200x) Transplanted patients following an immunosuppressor therapy are 80 times more likely to develop

More information

Immunological Tolerance

Immunological Tolerance Immunological Tolerance Introduction Definition: Unresponsiveness to an antigen that is induced by exposure to that antigen Tolerogen = tolerogenic antigen = antigen that induces tolerance Important for

More information

Essentials of Primary Care Pain Management Conference

Essentials of Primary Care Pain Management Conference Essentials of Primary Care Pain Management Conference September 16-17, 2017 4860 Y St., Suite 3020, Sacramento, CA 95617 Phone: (916) 734-1836 Fax: (916) 703-6045 Email: HS-CAPR@ucdavis.edu advancingpainrelief.ucdavis.edu

More information

THE ROLE OF TARGETED THERAPY AND IMMUNOTHERAPY IN THE TREATMENT OF ADVANCED CERVIX CANCER

THE ROLE OF TARGETED THERAPY AND IMMUNOTHERAPY IN THE TREATMENT OF ADVANCED CERVIX CANCER Gynecologic Cancer InterGroup Cervix Cancer Research Network THE ROLE OF TARGETED THERAPY AND IMMUNOTHERAPY IN THE TREATMENT OF ADVANCED CERVIX CANCER Linda Mileshkin, Medical Oncologist Peter MacCallum

More information

The Galectin-3 Inhibitor GR-MD-02 for Combination Cancer Immunotherapy

The Galectin-3 Inhibitor GR-MD-02 for Combination Cancer Immunotherapy The Galectin-3 Inhibitor GR-MD-02 for Combination Cancer Immunotherapy Supplemental Information to Corporate Presentation February 6, 2018 NASDAQ: GALT www.galectintherapeutics.com 2018 2017 Galectin Therapeutics

More information

Combining ADCs with Immuno-Oncology Agents

Combining ADCs with Immuno-Oncology Agents Combining ADCs with Immuno-Oncology Agents Chad May, PhD Senior Director Targeted Immunotherapy Oncology Research Unit, Pfizer 7 th Annual World ADC October 10, 2016 Cancer-Immunity Cycle Innate Immunity

More information

Curriculum Vitae. PERSONAL DATA Name: Harriet W. Hopf Birth Place: Madison, WI Citizenship: United States

Curriculum Vitae. PERSONAL DATA Name: Harriet W. Hopf Birth Place: Madison, WI Citizenship: United States Curriculum Vitae PERSONAL DATA Name: Harriet W. Hopf Birth Place: Madison, WI Citizenship: United States EDUCATION Years Degree Institution (Area of Study) 1978-1982 B.A. Yale University (Biology) New

More information

Advances in gastric cancer

Advances in gastric cancer ESMO Asia 2016 Industry Satellite Symposium 16 19 December 2016, Singapore Advances in gastric cancer Chair: Ian Chau With Mitsuru Sasako, Kei Muro and Yung-Jue Bang Saturday 17th December, 12:45-14:15

More information

James K. Stoller, MD, MS

James K. Stoller, MD, MS James K. Stoller, MD, MS Chair, Education Institute at Cleveland Clinic Cleveland, OH, US Cleveland Clinic's leading expert on physician leadership development offers provocative ideas and new perspectives

More information

FOCiS. Lecture outline. The immunological equilibrium: balancing lymphocyte activation and control. Immunological tolerance and immune regulation -- 1

FOCiS. Lecture outline. The immunological equilibrium: balancing lymphocyte activation and control. Immunological tolerance and immune regulation -- 1 1 Immunological tolerance and immune regulation -- 1 Abul K. Abbas UCSF FOCiS 2 Lecture outline Principles of immune regulation Self-tolerance; mechanisms of central and peripheral tolerance Inhibitory

More information

TITLE: Development of Antigen Presenting Cells for adoptive immunotherapy in prostate cancer

TITLE: Development of Antigen Presenting Cells for adoptive immunotherapy in prostate cancer AD Award Number: W8XWH-5-- TITLE: Development of Antigen Presenting Cells for adoptive immunotherapy in prostate cancer PRINCIPAL INVESTIGATOR: Mathias Oelke Ph.D. CONTRACTING ORGANIZATION: Johns Hopkins

More information

Synergistic combinations of targeted immunotherapy to combat cancer

Synergistic combinations of targeted immunotherapy to combat cancer Synergistic combinations of targeted immunotherapy to combat cancer Myung Ah Lee, M.D., Ph. D Division of Medical Oncology, Hepato-biliary pancreatic cancer center Seoul St. Mary s hospital, The Catholic

More information

EMERGING THERAPIES FOR BLOOD CANCERS:

EMERGING THERAPIES FOR BLOOD CANCERS: EMERGING THERAPIES FOR BLOOD CANCERS: Case Studies Adherence, Ethics and Other Nursing Management Challenges CONTINUING EDUCATION IS OFFERED FOR THIS ACTIVITY CONTENTS Welcome.............................................................

More information

Targeting the High-Risk Patient

Targeting the High-Risk Patient This programme is accredited by the European Board for Accreditation in Cardiology (EBAC) for 1 hour of external CME credit(s). Each participant should claim only those hours of credit that have actually

More information

Dr. Sause: Clinical, Research, and Administration. Vilija N. Avizonis, MD Radiation Oncologist; Intermountain Medical Center; Murray, Utah

Dr. Sause: Clinical, Research, and Administration. Vilija N. Avizonis, MD Radiation Oncologist; Intermountain Medical Center; Murray, Utah Dr. Sause: Clinical, Research, and Administration Vilija N. Avizonis, MD Radiation Oncologist; Intermountain Medical Center; Murray, Utah Objectives: Identify Dr. Sause's educational achievements Discuss

More information

IMMUNOTHERAPY IN THE TREATMENT OF CERVIX CANCER. Linda Mileshkin, Medical Oncologist Peter MacCallum Cancer Centre, Melbourne Australia

IMMUNOTHERAPY IN THE TREATMENT OF CERVIX CANCER. Linda Mileshkin, Medical Oncologist Peter MacCallum Cancer Centre, Melbourne Australia IMMUNOTHERAPY IN THE TREATMENT OF CERVIX CANCER Linda Mileshkin, Medical Oncologist Peter MacCallum Cancer Centre, Melbourne Australia Distinguishing self from non-self T cells trained in the thymus as

More information

Subject Index. Bcl-2, apoptosis regulation Bone marrow, polymorphonuclear neutrophil release 24, 26

Subject Index. Bcl-2, apoptosis regulation Bone marrow, polymorphonuclear neutrophil release 24, 26 Subject Index A1, apoptosis regulation 217, 218 Adaptive immunity, polymorphonuclear neutrophil role 31 33 Angiogenesis cancer 178 endometrium remodeling 172 HIV Tat induction mechanism 176 inflammatory

More information

IMMUNOLOGICAL ASPECTS OF NEOPLASIA THE ROLE OF THE THYMUS

IMMUNOLOGICAL ASPECTS OF NEOPLASIA THE ROLE OF THE THYMUS IMMUNOLOGICAL ASPECTS OF NEOPLASIA THE ROLE OF THE THYMUS Cancer Growth and Progression Volume 17 Series Editor: Hans E. Kaiser, D.Sc. Professor, Department of Pathology, School of Medicine, University

More information

Broadening horizons: medical nutrition for managing early Alzheimer s disease

Broadening horizons: medical nutrition for managing early Alzheimer s disease abstracts Broadening horizons: medical nutrition for managing early Alzheimer s disease A Corporate Sponsored Symposium held in conjunction with the Alzheimer s Association International Conference (AAIC)

More information

Scott Abrams, Ph.D. Professor of Oncology, x4375 Kuby Immunology SEVENTH EDITION

Scott Abrams, Ph.D. Professor of Oncology, x4375 Kuby Immunology SEVENTH EDITION Scott Abrams, Ph.D. Professor of Oncology, x4375 scott.abrams@roswellpark.org Kuby Immunology SEVENTH EDITION CHAPTER 11 T-Cell Activation, Differentiation, and Memory Copyright 2013 by W. H. Freeman and

More information

Natural Killer (NK) cells and Programmed cell death protein-1 (PD-1)

Natural Killer (NK) cells and Programmed cell death protein-1 (PD-1) Natural Killer (NK) cells and Programmed cell death protein-1 (PD-1) Sujan Badal, MS2; Zachary B. Davis, PhD; Jeffrey Miller, MD Department of Medicine, Division of Hematology, Oncology, and Transplantation

More information

Exploring the PD-L1 Pathway

Exploring the PD-L1 Pathway Active Within the tumor microenvironment Steps 1-3: Initiating and propagating anticancer immunity 1 may inhibit T-cell activity in the tumor microenvironment Dendritic cells capture cancer and then prime

More information

The Annexin V Apoptosis Assay

The Annexin V Apoptosis Assay The Annexin V Apoptosis Assay Development of the Annexin V Apoptosis Assay: 1990 Andree at al. found that a protein, Vascular Anticoagulant α, bound to phospholipid bilayers in a calcium dependent manner.

More information

PSYCHIATRY. THE POWER OFx. Experts. Experience. Execution. A Deeper Dive into Psychiatry. Scientifically-Driven Clinical Development

PSYCHIATRY. THE POWER OFx. Experts. Experience. Execution. A Deeper Dive into Psychiatry. Scientifically-Driven Clinical Development THE POWER OFx Experts. Experience. Execution. A Deeper Dive into Psychiatry Incidences of mental disorders such as depression, bipolar, anxiety disorders, and schizophrenia continue to grow around the

More information

Reprogramming Tumor Associated Dendritic Cells for Immunotherapy

Reprogramming Tumor Associated Dendritic Cells for Immunotherapy Reprogramming Tumor Associated Dendritic Cells for Immunotherapy Edgar Engleman, M.D. Professor of Pathology and Medicine Stanford University Disclosures: Founder of Dendreon, a biotechnology company that

More information

Current Position. Research activities - Publications. Athanasios Kotsakis

Current Position. Research activities - Publications. Athanasios Kotsakis Athanasios Kotsakis Athanasios Kotsakis was born in Athens in 1968 and is married with 3 children. He studied Medicine at the University of Athens and continued his training in Internal Medicine at the

More information

TITLE: Development of Antigen Presenting Cells for adoptive immunotherapy in prostate cancer

TITLE: Development of Antigen Presenting Cells for adoptive immunotherapy in prostate cancer AD Award Number: W8-XWH-5-- TITLE: Development of Antigen Presenting Cells for adoptive immunotherapy in prostate cancer PRINCIPAL INVESTIGATOR: Mathias Oelke, Ph.D. CONTRACTING ORGANIZATION: Johns Hopkins

More information

igh-sensitivity Cardiac Troponin - A Canadian Viewpoint from CIHR funded studies Friday May 30, 2014

igh-sensitivity Cardiac Troponin - A Canadian Viewpoint from CIHR funded studies Friday May 30, 2014 8:50-9:00 Welcome and Introduction Juravinski Cancer Center Lecture Theatre (4 th floor) 699 Concession St. Hamilton, ON L8V 5C2 Introduction to High-Sensitivity Cardiac Troponin Current State 9:00-9:45

More information

Immunotherapie: algemene principes

Immunotherapie: algemene principes Immunotherapie: algemene principes Prof. dr. Evelien Smits Tumorimmunologie, UAntwerpen 14 Oktober 2017, IKG evelien.smits@uza.be Concept of immune evasion Finn O. J. Ann Oncol. 2012 Sep; 23(Suppl 8):

More information

Coalition Director Nagi B. Kumar, Ph.D., R.D., FADA Moffitt Cancer Center

Coalition Director Nagi B. Kumar, Ph.D., R.D., FADA Moffitt Cancer Center Coalition Director Nagi B. Kumar, Ph.D., R.D., FADA Moffitt Cancer Center Dr. Nagi B. Kumar is a Senior Member in the Population Sciences Division, Director, Cancer Chemoprevention at the Moffitt Cancer

More information

Research in the Division of Cell Signalling and Immunology

Research in the Division of Cell Signalling and Immunology Research in the Division of Cell Signalling and Immunology Head of Division Deputy Head of Division Professor Colin Watts Professor Hari Hundal Division Secretary Laboratory Manager Mrs Naomi Bolser Mrs

More information

International Society of Breast Pathology. Immune Targeting in Breast Cancer. USCAP 2017 Annual Meeting

International Society of Breast Pathology. Immune Targeting in Breast Cancer. USCAP 2017 Annual Meeting International Society of Breast Pathology USCAP 2017 Annual Meeting Immune Targeting in Breast Cancer Ashley Cimino-Mathews, MD Assistant Professor of Pathology and Oncology The Johns Hopkins Hospital

More information

Tolerance 2. Regulatory T cells; why tolerance fails. Abul K. Abbas UCSF. FOCiS

Tolerance 2. Regulatory T cells; why tolerance fails. Abul K. Abbas UCSF. FOCiS 1 Tolerance 2. Regulatory T cells; why tolerance fails Abul K. Abbas UCSF FOCiS 2 Lecture outline Regulatory T cells: functions and clinical relevance Pathogenesis of autoimmunity: why selftolerance fails

More information

American Cancer Society, Inc. Extramural Grants

American Cancer Society, Inc. Extramural Grants Page: 1 Cancer Control Career Development Award for Primary Care Physicians (CCCDA) CCCDA-14-013-01 Cole, Allison M., MD MENTOR: Baldwin, Laura-Mae, MD, MPH Department of Family Medicine Improving Colorectal

More information

Immuno-Oncology: Perspectives on Current Therapies & Future Developments

Immuno-Oncology: Perspectives on Current Therapies & Future Developments Transcript Details This is a transcript of an educational program accessible on the ReachMD network. Details about the program and additional media formats for the program are accessible by visiting: https://reachmd.com/programs/medical-industry-feature/immuno-oncology-perspectives-currenttherapies-future-developments/9502/

More information

Keynote Speaker. Dr. Patrick Hwu, MD Head, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center

Keynote Speaker. Dr. Patrick Hwu, MD Head, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center Keynote Speaker Dr. Patrick Hwu, MD Head, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center Keynote Speaker Patrick Hwu, MD Head, Division of Cancer Medicine, The University of

More information

Immunology for the Practicing Physician

Immunology for the Practicing Physician Immunology for the Practicing Physician Immunology for the Practicing Physician Edited by Jon R. Schmidtke and Ronald M. Ferguson Departments of Surgery and Microbiology University of Minnesota Medical

More information

Immunology Lecture 4. Clinical Relevance of the Immune System

Immunology Lecture 4. Clinical Relevance of the Immune System Immunology Lecture 4 The Well Patient: How innate and adaptive immune responses maintain health - 13, pg 169-181, 191-195. Immune Deficiency - 15 Autoimmunity - 16 Transplantation - 17, pg 260-270 Tumor

More information

Understanding Checkpoint Inhibitors: Approved Agents, Drugs in Development and Combination Strategies. Michael A. Curran, Ph.D.

Understanding Checkpoint Inhibitors: Approved Agents, Drugs in Development and Combination Strategies. Michael A. Curran, Ph.D. Understanding Checkpoint Inhibitors: Approved Agents, Drugs in Development and Combination Strategies Michael A. Curran, Ph.D. MD Anderson Cancer Center Department of Immunology Disclosures I have research

More information

Radiation and Immunotherapy

Radiation and Immunotherapy Radiation and Immunotherapy What s it All About? Encouse Golden, MD, PhD Assistant Professor of Radiation Oncology 10.25.16 www.weillcornell.org Silvia Formenti, MD Chairman of Radiation Oncology, Sandra

More information

ORIEN NOVA TEAM SCIENCE AWARD

ORIEN NOVA TEAM SCIENCE AWARD ORIEN NOVA TEAM SCIENCE AWARD CALL FOR LETTERS OF INTENT BACKGROUND: The Oncology Research Information Exchange Network (ORIEN) is a unique alliance to integrate data sharing and collaborative learning

More information

Diseases of Immunity 2017 CL Davis General Pathology. Paul W. Snyder, DVM, PhD Experimental Pathology Laboratories, Inc.

Diseases of Immunity 2017 CL Davis General Pathology. Paul W. Snyder, DVM, PhD Experimental Pathology Laboratories, Inc. Diseases of Immunity 2017 CL Davis General Pathology Paul W. Snyder, DVM, PhD Experimental Pathology Laboratories, Inc. Autoimmunity Reflects a loss of immunologic tolerance Mechanisms Auto-antibodies

More information

Moving Forward with Immunotherapies for Cancer

Moving Forward with Immunotherapies for Cancer A Virtual Think Tank Executive Summary Moving Forward with Immunotherapies for Cancer By: Barbara Gilmore, Senior Consultant, Transformational Health, Frost & Sullivan Frost & Sullivan recently invited

More information

Immune Regulation and Tolerance

Immune Regulation and Tolerance Immune Regulation and Tolerance Immunoregulation: A balance between activation and suppression of effector cells to achieve an efficient immune response without damaging the host. Activation (immunity)

More information

Priming the Immune System to Kill Cancer and Reverse Tolerance. Dr. Diwakar Davar Assistant Professor, Melanoma and Phase I Therapeutics

Priming the Immune System to Kill Cancer and Reverse Tolerance. Dr. Diwakar Davar Assistant Professor, Melanoma and Phase I Therapeutics Priming the Immune System to Kill Cancer and Reverse Tolerance Dr. Diwakar Davar Assistant Professor, Melanoma and Phase I Therapeutics Learning Objectives Describe the role of the immune system in cancer

More information

CCO Annual Report (2016) Editorial Office

CCO Annual Report (2016) Editorial Office CCO Annual Report (2016) Editorial Office editor@thecco.net Outline of the Report 1.Basic Information 2.Message from the Editors-in-Chief 3.Distribution of Editorial Board Members 4.Number of Published

More information

Promising Bifunctional Agents in Immuno- Oncology: A Roundtable Discussion with the Experts

Promising Bifunctional Agents in Immuno- Oncology: A Roundtable Discussion with the Experts Transcript Details This is a transcript of a continuing medical education (CME) activity accessible on the ReachMD network. Additional media formats for the activity and full activity details (including

More information

SEVENTH EDITION CHAPTER

SEVENTH EDITION CHAPTER Judy Owen Jenni Punt Sharon Stranford Kuby Immunology SEVENTH EDITION CHAPTER 16 Tolerance, Autoimmunity, and Transplantation Copyright 2013 by W. H. Freeman and Company Immune tolerance: history * Some

More information

HODGKIN S AND NON-HODGKIN S LYMPHOMA

HODGKIN S AND NON-HODGKIN S LYMPHOMA HODGKIN S AND NON-HODGKIN S LYMPHOMA edited by JOHN P. LEONARD, MD Center for Lymphoma and Myeloma Weill Medical College of Cornell University New York Presbyterian Hospital New York, NY MORTON COLEMAN,

More information