The Continuous Update Project: concept, purpose, methods and results

Transcription

1 The Continuous Update Project: concept, purpose, methods and results Teresa Norat August Montreal, Canada

2 Continuous Update Project Keep Report updated into the future WCRF/AICR working with team at Same principles: - Systematically review evidence - Meta analysis - Panel of experts - draw conclusions - make recommendations Various outputs

3 Continuous Update Project

4 MEMBERS AND OBSERVERS OF THE CUP PANEL q Alan Jackson (Chair) CBE,MD,FRCP,FRCPCH,FRCPath University of Southampton,UK q Anne McTiernan, MD, PhD Fred Hutchinson Cancer Research Center Seattle, WA, USA q Elisa Bandera, MD, PhD The Cancer Institute of New Jersey United States q Hilary J Powers, PhD RNutr University of Sheffield, UK q Stephen Hursting PhD MPH University of Texas Austin, TX, USA q Elio Riboli (Observer) MD, HonFPH, FMedSci Imperial College London,UK q John Milner, PhD (Observer) National Cancer Institute Bethesda, MD United States q Ricardo Uauy, MD PhD Instituto de Nutricion y Tecnologia de los Alimentos Santiago, Chile

5 The Continuous Update Project rolling programme YEAR CANCER TYPES BREAST BREAST BREAST BREAST PROSTATE PROSTATE PROSTATE PROSTATE PROSTATE COLON AND RECTUM COLON AND RECTUM COLON AND RECTUM COLON AND RECTUM PANCREAS PANCREAS PANCREAS BREAST CANCER SURVIVORS BREAST CANCER SURVIVORS ENDOMETRIUM ENDOMETRIUM OVARY OVARY BLADDER KIDNEY BREAST 2008 BREAST BREAST CANCER SURVIVORS 17 CANCERS AND CANCER SURVIVORS

6 CUP Database CUP database CUP Team

7 Strategic decisions 1. Updating the database: " Cohort studies, case-control studies nested in cohort studies " Randomised trials " Peer-reviewed journals (English language) " References and abstracts of other relevant studies Ref Man (Identifiers)

8 Strategic decisions 2. When to update a meta-analysis? " Three or more publications added after the 2007 second expert report " By recommendation of the Panel

9 Number of articles from cohort studies in the CUP database for selected cancers by publication period Kidney Bladder 101 Ovary Search literature review Second expert report (before 2006) Endometrial Pancreas Continuous update project ( ) Prostate Colon Breast

10 Diet and Cancer Report website

11 Colorectal cancer matrices 2007 and 2011 In 2011, the evidence that foods containing dietary fibre modify the risk of colorectal cancer was upgraded from probable to convincing

12 Colorectal cancer and dietary fibre per 10 g increase CUP Colorectal cancer report 2010 BMJ 2011;4:d6617 doi: /bmj.d6617

13 Colorectal cancer and dietary fibre (by food source) CUP Colorectal cancer report 2010 BMJ 2011;4:d6617 doi: /bmj.d6617

14 Colorectal cancer and whole grain foods CUP Colorectal cancer report 2010 BMJ 2011;4:d6617 doi: /bmj.d6617

15 Colorectal cancer report 2010 Gastroenterology 2011 h6p://dx.doi.org/10.105/j.gastro Colorectal cancer, fruits and vegetables Highest vs Lowest Dose- response (per 100 grams)

16 Colorectal cancer, red and processed meats CUP Colorectal cancer report 2010 PLoS One 2011;6(6):e20456

17 ICL Team Journal Publications Colorectal cancer q Carbohydrates, glycemic index, glycemic load Cancer Causes Control Apr;2(4):521-5 q Dietary fibre, whole grains BMJ Nov 10;4:d6617. doi: /bmj.d6617 q Red and processed meat PLoS One. 2011;6(6):e20456 q Dairy products Ann Oncol Jan;2(1):7-45 q Fruits and vegetables Gastroenterology Jul;141(1): q 25-hydroxyvitamin D status Cancer Epidemiol Biomarkers Prev May;20(5):100-16

18 ICL Team Journal Publications Breast cancer q Dietary and blood carotenoids Am J Clin Nutr Jul q Fruits and vegetables Breast Cancer Res Treat Jun 16 q Dietary fiber Ann Oncol Jun;2(6): Pancreatic cancer q Height. Cancer Causes Control Jun 12 q Dietary fructose, carbohydrates, glycemic index Ann Oncol Apr 26 q Body mass index, abdominal fatness Ann Oncol Apr; 2(4):84-52

19 Breast cancer and dietary fibre (by food source) Ann Oncol 2012;2:

20 What next? Breast cancer survivors. Mortality, second cancers (Nov 2012)

21 What next? Reports on endometrial and ovarian cancer (October 2012) Timeline: ICL Cancers Breast Prostate Colorectal Adenomas Pancreas Breast Ca Surv Endometrium Ovary Kidney Bladder Liver Gallbladder Stomach Oesophagus MPL Nasopharynx Lung Skin Cervix JanFebMarAprMayJunJul AugSepOctNovDecJanFebMarAprMayJunJul AugSepOctNovDecJanFebMarAprMayJunJul AugSepOctNovDecJanFebMarAprMayJunJul AugSepOctNovDecJanFebMarAprMayJunJul AugSepOctNovDecJanFebMarAprMayJunJul AugSepOctNovDec Protocol Updating Database Continuous Update Report first draft Report review Report discussed by Panel Panel meeting

22 CUP Team Ana Rita Vieira Rui Vieira Thanks! Teresa Norat Doris Chan Deborah Navarro Rosenblatt Dagfinn Aune Doris Chan Darren Greenwood, University of Leeds, Statistical Advisor (not in photo)