12 Dynamic Interactions between Hematopoietic Stem and Progenitor Cells and the Bone Marrow: Current Biology of Stem Cell Homing and Mobilization

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1 Table of Contents: PART I: Molecular and Cellular Basis of Hematology 1 Anatomy and Pathophysiology of the Gene 2 Genomic Approaches to Hematology 3 Regulation of Gene Expression, Transcription, Splicing, and RNA Metabolism 4 Protein Synthesis, Processing, and Trafficking 5 Protein Architecture: Relationship of Form and Function 6 Signaling Transduction and Regulation of Cell Metabolism 7 Pharmacogenomics and Hematologic Diseases PART II: Cellular Basis of Hematology 8 Hematopoietic Stem Cell Biology 9 Hematopoietic Microenvironment 10 Cell Adhesion 11 Hematopoietic Cell Trafficking and Chemokines 12 Dynamic Interactions between Hematopoietic Stem and Progenitor Cells and the Bone Marrow: Current Biology of Stem Cell Homing and Mobilization 13 Vascular Growth in Health and Disease 14 Principles of Cytokine Signaling 15 Control of Cell Division 16 Cell Death PART III: Immunologic Basis of Hematology 17 Overview and Compartmentalization of the Immune System 18 B-Cell Development 19 T-Cell Immunity 20 Natural Killer Cell Immunity 21 Dendritic Cell Biology 22 Complement and Immunoglobulin Biology 23 Tolerance and Autoimmunity PART IV: Disorders of Hematopoietic Cell Development

2 24 Biology of Erythropoiesis, Erythroid Differentiation, and Maturation 25 Granulocytopiesis and Monocytopoiesis 26 Thrombocytopoiesis 27 Inherited Forms of Bone Marrow Failure 28 Aplastic Anemia 29 Paroxysmal Nocturnal Hemoglobinuria 30 Acquired Disorders of Red Cell, White Cell, and Platelet Production PART V: Red Blood Cells 31 Pathobiology of the Human Erythrocyte and Its Hemoglobins 32 Approach to Anemia in the Adult and Child 33 Pathophysiology of Iron Homeostasis 34 Disorders of Iron Homeostasis: Iron Deficiency and Overload 35 Anemia of Chronic Diseases 36 Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias 37 Megaloblastic Anemias 38 Thalassemia Syndromes 39 Pathobiology of Sickle Cell Disease 40 Sickle Cell Disease - Clinical Features and Management 41 Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias 42 Red Blood Cell Enzymopathies 43 Red Blood Cell Membrane Disorders 44 Autoimmune Hemolytic Anemia 45 Extrinsic Nonimmune Hemolytic Anemias PART VI: Non-Malignant Leukocytes 46 Neutrophilic Leukocytosis, Neutropenia, Monocytosis and Monocytopenia 47 Lymphocytosis, Lymphocytopenia, Hypergammaglobulinemia and Hypogammaglobulinemia 48 Disorders of Phagocyte Function

3 49 Congenital Disorders of Lymphocyte Function 50 Histiocytic Disorders 51 Lysosomal Storage Diseases: Perspectives and Principles 52 Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases PART VII: Hematologic Malignancies 53 Progress in the Classification of Myeloid Neoplasms: Clinical Implications 54 Conventional and Molecular Cytogenetic Basis of Hematologic Malignancies 55 Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies 56 Radiation Therapy in the Treatment of Hematologic Malignancies 57 Pathobiology of Acute Myeloid Leukemia 58 Clinical Manifestations and Treatment of Acute Myeloid Leukemia 59 Myelodysplastic Syndromes: Biology and Treatment 60 Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults 61 Acute Myeloid Leukemia in Children 62 Myelodysplastic and Myeloproliferative Neoplasms in Children 63 Pathobiology of Acute Lymphoblastic Leukemia 64 Clinical Manifestations and Treatment of Acute Lymphoblastic Leukemia in Children 65 Acute Lymphoblastic Leukemia in Adults 66 Chronic Myeloid Leukemia 67 The Polycythemias 68 Essential Thrombocythemia 69 Primary Myelofibrosis 70 Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia, and the Hypereosinophilic Syndromes 71 Mast Cells and Systemic Mastocytosis 72 The Pathologic Basis for the Classification of Non-Hodgkin and Hodgkin Lymphomas 73 Origins of Hodgkin Lymphoma

4 74 Hodgkin Lymphoma: Clinical Manifestations, Staging, and Therapy 75 Origin of Non-Hodgkin Lymphoma 76 Chronic Lymphocytic Leukemia 77 Hairy Cell Leukemia 78 Clinical Manifestations and Treatment of Marginal Zone Lymphomas (Extranodal/Malt, Splenic, and Nodal) 79 Clinical Manifestations, Staging, and Treatment of Follicular Lymphoma 80 Mantle Cell Lymphoma 81 Diagnosis and Treatment of Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma 82 Virus-Associated Lymphoma 83 Malignant Lymphomas in Childhood 84 T-Cell Lymphomas 85 Plasma Cell Neoplasms 86 Waldenstrom Macroglobulinemia and Lymphoplasmacytic Lymphoma 87 Immunoglobuin Light-Chain Amyloidosis (Primary Amyloidosis) PART VIII: Comprehensive Care of Patients with Hematologic Malignancies 88 Clinical Approach to Infections in the Compromised Host 89 Indwelling Access Devices 90 Nutritional Issues in Patients with Hematologic Malignancies 91 Psychosocial Aspects of Hematologic Disorders 92 Pain Management and Antiemetic Therapy in Hematologic Disorders 93 Palliative Care 94 Late Complications of Hematologic Diseases and Their Therapies PART IX: Cell-Based Therapies 95 Overview and Historical Perspective of Cell-Based Therapies 96 Practical Aspects of Hematologic Stem Cell Harvesting and Mobilization 97 Preclinical Process of Cell-Based Therapies 98 Graft Engineering and Cell Processing

5 99 Principles of Cell-Based Genetic Therapies 100 Mesenchymal Stromal Cells 101 T Cell Therapy of Hematological Diseases 102 Natural Killer Cell-Based Therapies 103 Dendritic Cell Therapies PART X: Transplantation 104 Overview of Hematopoietic Cell Transplantation 105 Indications and Outcome of Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies in Adults 106 Unrelated Donor Hematopoietic Cell Transplantation 107 Haploidentical Hematopoietic Cell Transplantation 108 Unrelated Donor Cord Blood Transplantation for Hematologic Malignancies 109 Graft-versus-Host Disease and Graft-versus-Leukemia Responses 110 Complications After Hematopoietic Stem Cell Transplantation PART XI: Transfusion Medicine 111 Human Blood Group Antigens and Antibodies 112 Principles of Red Blood Cell Transfusion 113 Principles of Platelet Transfusion Therapy 114 Human Leukocyte Antigen and Human Neutrophil Antigen Systems 115 Principles of Neutrophil (Granulocyte) Transfusions 116 Principles of Plasma Transfusion: Plasma, Cryoprecipitate, Albumin, and Immunoglobulins 117 Preparation of Plasma-Derived and Recombinant Human Plasma Proteins 118 Transfusion Therapy for Coagulation Factor Deficiencies 119 Hemapheresis 120 Transfusion Reactions to Blood and Cell Therapy Products 121 Transfusion-Transmitted Diseases 122 Transfusion Medicine in Hematopoietic Stem Cell and Solid Organ Transplantation 123 Pediatric Transfusion Medicine

6 PART XII: Hemostasis and Thrombosis 124 Overview of Hemostasis and Thrombosis 125 The Blood Vessel Wall 126 Megakaryocyte and Platelet Structure 127 Molecular Basis for Platelet Function 128 Molecular Basis of Blood Coagulation 129 Regulatory Mechansims in Hemostasis 130 Clinical Approach to the Patient with Bleeding or Bruising 131 Laboratory Evaluation of Hemostatic and Thrombotic Disorders 132 Acquired Disorders of Platelet Function 133 Diseases of Platelet Number: Immune Thrombocytopenia, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura 134 Thrombocytopenia Caused by Platelet Destruction, Hypersplenism, or Hemodilution 135 Heparin-Induced Thrombocytopenia 136 Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome 137 Hemophilia A and B 138 Inhibitors in Hemophilia A and B 139 Rare Coagulation Factor Deficiencies 140 Structure, Biology, and Genetics of von Willebrand Factor 141 Disseminated Intravascular Coagulation 142 Hypercoagulable States 143 Antiphospholipid Syndrome 144 Venous Thromboembolism 145 Mechanical Interventions in Arterial and Venous Thrombosis 146 Atherothrombosis 147 Stroke 148 Acute Coronary Syndromes 149 Atrial Fibrillation

7 150 Peripheral Artery Disease 151 Antithrombotic Drugs 152 Disorders of Coagulation in the Neonate PART XIII: Consultative Hematology 153 Hematologic Changes in Pregnancy 154 Hematologic Manifestations of Childhood Illness 155 Hematologic Manifestations of Liver Disease 156 Hematologic Manifestations of Systemic Disease: Renal Disease 157 Hematologic Manifestations of Cancer 158 Integrative Therapies in Patients with Hematologic Diseases 159 Hematologic Manifestations of HIV/AIDS 160 Hematologic Aspects of Parasitic Diseases 161 Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis 162 The Spleen and Its Disorders 163 Hematology in Aging 164 (Online Only) Resources For The Hematologist: Interpretive Comments and Selected Reference Values for Neonatal, Pediatric, and Adult Populations