Evidence-Based HPV Disease Prevention HPV VACCINE
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1 Evidence-Based HPV Disease Prevention HPV VACCINE
2 Educating and normalizing vaccine compliance for the teen population Leisha Nolen, MD PhD
3 Enroll in Electronic Poll System In the texting app in your phone: Create a new message to phone number Type in the message leishanolen983
4
5 What percent of teens that you saw in the past year were fully vaccinated against HPV?
6 HPV Infection Most females and males will be infected with at least one type of mucosal HPV at some point in their lives Estimated 79 million Americans currently infected 14 million new infections/year in the US HPV infection is most common in people in their teens and early 20s Most people will never know that they have been infected Satterwhite et al. Sex Transm Dis. 2013
7 Cervical Cancer Cervical cancer is the most common HPV-associated cancer among women 528,00 new cases and 266,000 deaths world-wide in ,000 new cases and 4,000 deaths in the U.S. in 2013 Half of cervical cancers occur in women <50 years A quarter of cervical cancers occur in women years and
8 Cancers Caused by HPV per Year, U.S., Cancer site Percentage probably caused by any HPV type Number probably caused by any HPV type Female Male Both Sexes Cervix 91% 10, ,600 Vagina 75% Vulva 69% 2, ,500 Penis 63% Anus 91% 3,200 1,600 4,800 Rectum 91% Oropharynx 70% 2,000 9,600 11,600 TOTAL 19,400 12,100 31,500 Based on Viens et al. MMWR
9 HPV-Associated Cancer Rates by Sex, Race and Ethnicity, United States, Based on Viens et al. MMWR
10 Cervical Cancer in Alaska Average Annual Cervical Cancer Incidence and Mortality in Alaska State of Alaska Epidemiology Bulletin, Jan The incidence rate for the overall US population is approximately 8/100,000 for this same time period (CDC, Cancer Statistics)
11 Average Number of Cases of Cancer per Year Based on Viens et al. MMWR
12 HPV4 Vaccine
13 HPV9 Vaccine
14 Adolescent Vaccination Coverage United States, Percent Vaccinated Tdap 1 MenACWY 1 HPV (F) 1 HPV (M) 3 HPV (F) 2 MenACWY 3 HPV (M) Survey Year Reagan-Steiner et al. MMWR 2016.
15 Information from the Alaska Immunization Program
16 HPV VACCINE SAFETY
17 PATIENT REFUSAL OF VACCINE
18 Over 10 Years of HPV Vaccine Safety Data HPV vaccine is safe Gee, et al. Hum Vaccin Immunother
19 Reactions to the HPV Vaccine Injection site reactions: pain, redness, and/or swelling in the arm where the shot was given Systemic: fever, headaches Brief fainting spells Related symptoms, such as jerking movements, can happen soon after any injection, including HPV vaccine Patients should be seated (or lay down) during vaccination and remain in that position for 15 minutes
20 Who Should Not Get the Vaccine HPV vaccines should not be given to anyone who has had a previous allergic reaction to the vaccine or who has an allergy to yeast (Gardasil/Gardasil 9) Anyone who already has had HPV4 should not get HPV9
21 HPV VACCINE IMPACT Monitoring Impact of HPV Vaccine Programs on HPV-Associated Outcomes
22 Prevalence of HPV before & after introduction of HPV vaccination in the United States Prevalence, % % decline 10 0 Any HPV Non 4vHPV HR 4vHPV Any HPV Non 4vHPV HR 4vHPV An years years Markowitz L et al. Pediatrics
23 Systematic Review and Meta-Analysis: Population-Level Impact of HPV Vaccination Review of 20 studies in 9 high income countries In countries with >50% coverage, among year olds The prevalence of two most dangerous HPV types (16 and 18) decreased at least 68% Anogenital warts decreased by ~61% Evidence of people being protected who were not vaccinate If enough people are vaccinated the virus cannot spread easily and even people who did not get vaccine get exposed to less virus Some evidence of cross protection against other HPV types Drolet et al. Lancet Infect Dis
24 HPV Vaccine Duration of Protection Studies suggest that vaccine protection is long-lasting No evidence of waning protection Available evidence indicates protection for at least 10 years Multiple studies are in progress to monitor Two major studies are being done here in Alaska ACIP. Summary Report. June 22-23, 2016.
25 HPV Vaccination Is HPV Vaccine is SAFE Benefits far outweigh any potential risks Safety studies findings for HPV vaccination are reassuring and similar to MenACWY and Tdap vaccine safety reviews HPV Vaccine WORKS Population impact against early and mid outcomes have been reported in multiple countries HPV Vaccine Protection LASTS Studies suggest that vaccine protection is long-lasting No evidence of waning protection
26 Let s Protect Our Patients
27 Who should not get the HPV 9 vaccine?
28 HPV Vaccine Recommendation CDC recommends routine vaccination at age 11 or 12 years to prevent HPV cancers The vaccination series can be started at age 9 years Meites et al. MMWR
29 Dosing Schedules Starting the vaccine series before the 15th birthday Recommended schedule is 2 doses of HPV vaccine Second dose should be administered 6 12 months after the first dose (0, 6 12 month schedule) Minimum interval between dose one and dose two in a 2-dose schedule is 5 months
30 Dosing Schedules Starting the vaccine series on or after the 15th birthday Recommended schedule is 3 doses of HPV vaccine Second dose should be administered 1 2 months after the first dose, and the third dose should be administered 6 months after the first dose (0, 1 2, 6 month schedule) Minimum interval between dose one and dose three in a 3-dose schedule is 5 months Also recommended for immunocompromised patients 9-26 years old
31 HPV Vaccine Recommendations: Catch Up/Late All females through age 26 years All males through age 21 years All males up to age 26 who are gay, bisexual, and other men who have sex with men (MSM), transgender people, and people with certain immunocompromising conditions (including HIV infection) Males aged 22 through 26 years may be vaccinated 34 Meites et al. MMWR
32 How Can We Increase HPV Vaccine Rates? Talk About It
33 WHO STARTS THE DISCUSSION OF THE HPV VACCINE?
34 Stokley et al. MMWR Reasons parents won t initiate HPV vaccination for children Not sexually active Not recommended Safety concern/side effects Not needed or necessary Lack of knowledge Percent
35 Give an Effective Recommendation to Receive HPV Vaccine at Ages 11 or 12 Many moms in focus groups stated that they trust their child s health providers and would get the vaccine for their child as long as they received a recommendation from the health providers An effective recommendation from you is the main reason parents decide to vaccinate Smith et al. Vaccine Unpublished CDC data, 2013.
36 What is an EFFECTIVE recommendation for HPV vaccination?
37 Same Way Same Day
38 Make an Effective Recommendation Same way: Effective recommendations group all of the adolescent vaccines Recommend HPV vaccination the same way you recommend Tdap & meningococcal vaccines. Same day: Recommend HPV vaccine today Recommend HPV vaccination the same day you recommend Tdap & meningococcal vaccines. Brewer at al. Pediatrics Unpublished CDC data, 2013.
39 Your preteen needs three vaccines today to protect against meningitis, HPV cancers, and pertussis. Brewer at al. Pediatrics
40 Some Parents Need Reassurance Many parents simply accept this bundled recommendation Some parents may be interested in vaccinating, yet still have questions. Interpret a question as they need additional reassurance from YOU, the clinician they trust with their child s health care Ask parents about their main concern (be sure you are addressing their real concern) Unpublished CDC data, 2013.
41 If a parent declines today Declination is not final. The conversation can be revisited. End the conversation with at least 1 action you both agree on. Because waiting to vaccinate is the risky choice, many pediatricians ask the parent to sign a Declination Form.
42 What parent concerns you see
43 References Advisory Committee on Immunization Practices. Summary Report. June 22-23, Available at Ali H, et al. Genital warts in young Australians five years into national human papillomavirus vaccination programme: national surveillance data BMJ 2013; 346 :f2032. Baldur-Felskov et al. Trends in the incidence of cervical cancer and severe precancerous lesions in Denmark, Cancer Causes Control 2015 Aug;26(8): Benard VB, Castle PE, Jenison SA, et al. Population-Based Incidence Rates of Cervical Intraepithelial Neoplasia in the Human Papillomavirus Vaccine Era. JAMA Oncol. Published online September 29, doi: /jamaoncol Brewer NT, et al. Announcements versus conversations to improve HPV vaccination coverage: A randomized trial. Pediatrics (1). Drolet et al. Population-level impact and herd effects following human papillomavirus vaccination programmes: a systematic review and meta-analysis. Lancet Infect Dis May;15(5): Gee, et al. Quadrivalent HPV vaccine safety review and safety monitoring plans for nine-valent HPV vaccine in the United States. Hum Vaccin Immunother Jun; 12(6): Hariri S, et al. Population-based trends in high-grade cervical lesions in the early human papillomavirus vaccine era in the United States. Cancer, 121: Healy CM, et al. Parent and provider perspectives on immunization: are providers overestimating parental concerns? Vaccine. 2014; 32(5): Henrikson NB, et al. A public-private partnership addressing vaccine hesitancy in Washington State Available at: Institute of Medicine. Adverse Effects of Vaccines: Evidence and Causality. The National Academies Press, Koshiol JE, et al. Rate and predictors of new genital warts claims and genital warts-related healthcare utilization among privately insured patients in the United States. Sex Transm Dis. 2004;31: Machalek et al. Human Papillomavirus Prevalence in Unvaccinated Heterosexual Men After a National Female Vaccination Program. J Infect Dis (2017) 215 (2): Published: 03 November DOI: /infdis/jiw530 Markowitz LE, et al. Prevalence of HPV After Introduction of the Vaccination Program in the United States. Pediatrics. 2016;137(2). Meites E, Kempe A, Markowitz LE. Use of a 2-Dose Schedule for Human Papillomavirus Vaccination Updated Recommendations of the Advisory Committee on Immunization Practices. MMWR. 2016;65(49); Petrosky et al. Use of 9-Valent Human Papillomavirus (HPV) Vaccine: Updated HPV Vaccination Recommendations of the Advisory Committee on Immunization Practices. MMWR (11); Pollock et al. Reduction of low- and high-grade cervical abnormalities associated with high uptake of the HPV bivalent vaccine in Scotland. Br J Cancer , Reagan-Steiner S, et al. National, Regional, State, and Selected Local Area Vaccination Coverage Among Adolescents Aged Years United States, MMWR Morb Mortal Wkly Rep. 2016;65: Satterwhite et al. Sexually transmitted infections among US women and men: prevalence and incidence estimates, Sex Transm Dis Mar;40(3): Schiffman M. Castle PE. Arch Pathol Lab Med. Human papillomavirus: epidemiology and public health Aug;127(8): Smith PJ, et al. HPV vaccination coverage of teen girls: the influence of health care providers. Vaccine Mar 18;34(13): Stokley S,, et al. Human papillomavirus vaccination coverage among adolescents, , and postlicensure vaccine safety monitoring, United States. MMWR Morb Mortal Wkly Rep Jul 25;63(29): Temte JL. Comment: Timing of HPV Vaccine. Available at vaccine- Viens LJ, et al. Human papillomavirus associated cancers United States, MMWR. 2016;65:661 6.
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