UK Biobank. Death and Cancer Outcomes Report. September
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1 UK Biobank Death and Cancer Outcomes Report September
2 Contents 1. Introduction Data on deaths Figure 2.1: Numbers of the 20 most common causes of death Table 2.1: Numbers by age group and sex Table 2.2: Numbers by year of death Data on incident cancers Fig 3.1: Numbers of the 20 most common incident cancers, diagnosed after date of recruitment... 6 Table 3.1: Numbers by age group and sex Table 3.2: Numbers by year of diagnosis Data on prevalent cancers Figure 4.1: Numbers of the 20 most common prevalent cancers, diagnosed before date of recruitment.. 9 Table 4.1: Numbers by age group and sex Table 4.2: Numbers by year of diagnosis Introduction UK Biobank receives death notifications and cancer diagnoses on a regular basis through linkage to national death and cancer registries, as described elsewhere: This report provides a description of the 20 most common primary causes of deaths and types of cancers, currently in the UK Biobank resource, by age group, sex and year. Please note: This report (and the online Data Showcase) contains all notifications of deaths and cancers. However, the date of complete follow-up (censoring date) for analyses should be taken to be January 2016 for deaths from E&W and November 2015 for deaths from Scotland. For cancers, date of complete follow-up is September 2014 for E&W and November 2014 for Scotland. In your dataset, please do check that your censoring date refers to the date of complete follow-up (rather than the most recent registration). A small number of participants may have delayed death registration owing to coroner s report. These will be included in the database, as and when they are received. 2
3 Only the first occurrence of a malignant cancer for an individual participant is included in this report. The contents of this document will be updated periodically, as and when follow-up data is incorporated into the UK Biobank Resource. Please note that data is currently incomplete for cancers registered in
4 2. Data on deaths Figure 2.1: Numbers of the 20 most common causes of death (ICD) Ischaemic heart disease(i20:i25) Lung cancer (C34) Colorectal cancer (C18:C20) Breast cancer (C50) Lymphoid and haematopoietic cancer (C81:C96) Stroke (I60:I68, G35, H34) Pancreatic cancer (C25) Prostate cancer (C61) Brain cancer (C71) Oesophageal cancer (C15) Emphysema/chronic obstructive pulmonary disease (J43:J44) Ovarian cancer (C56) Liver cancer (C22) Kidney cancer (C64) Mesothelioma (C45) Stomach cancer (C16) Other interstitial pulmonary diseases (J84) Influenza and pneumonia (J09-J18) Bladder cancer (C67) Malignant melanoma (C43) ,176 1,506 1, No. participants 4
5 Table 2.1: Numbers of the 20 most common causes of death by age group and sex Below to <50 50 to <60 60 to <70 years years years 70 to <80 years Male Female Ischaemic heart disease Lung cancer Colorectal cancer Breast cancer Lymphoid and haematopoietic cancer Stroke Pancreatic cancer Prostate cancer Brain cancer Oesophageal cancer Emphysema/chronic obstructive pulmonary disease Ovarian cancer Liver cancer Kidney cancer Mesothelioma Other interstitial pulmonary diseases Stomach cancer Influenza and pneumonia Bladder Cancer Malignant Melanoma Top 20 deaths total Other deaths total Total Deaths ,205 7,016 4,767 8,783 5,678 5
6 Table 2.2: Numbers of the 20 most common causes of death by year of death (recruitment period) Ischaemic heart disease Lung cancer Colorectal cancer Breast cancer Lymphoid and haematopoietic cancer Stroke Pancreatic cancer Prostate cancer Brain cancer Oesophageal cancer Emphysema/chronic obstructive pulmonary disease Ovarian cancer Liver cancer Kidney cancer Mesothelioma Other Interstitial pulmonary diseases Stomach cancer Influenza and pneumonia Bladder Cancer Malignant melanoma Top 20 deaths total Other deaths Total Deaths 2,675 1,776 1,987 2,349 2,598 2,
7 3. Data on Incident cancers Figure 3.1: Numbers of the 20 most common incident cancers (ICD), diagnosed after date of recruitment Other malignant skin cancer(c44) Breast cancer(c50) Prostate Cancer(C61) Colorectal cancer(c18:c20) Lymphoid and haematopoietic cancer(c81:c96) Trachea, bronchial and lung cancer(c33:c34) Malignant melanoma(c43) Uterine cancer(c54:c55) Renal pelvis, ureter, bladder and urethra cancer(c65:c68.0) Kidney cancer(c64) Ovarian cancer(c56) Pancreatic cancer (C25) Oesophageal cancer(c15) Brain Cancer(C71) Stomach cancer(c16) Liver cancer(c22) Mesothelioma(C45) Thyroid cancer(c73) Tongue cancer(c01:c02) Other connective and soft tissue cancer(c49) ,155 1,548 1,858 2,534 4,560 4,531 7, no.participants 7
8 Table 3.1: Numbers of the 20 most common incident cancers by age group and sex 40 to < 50 years 50 to < 60 years 60 to < 70 years 70 to < 80 years Missing age Other malignant skin cancer(c44) 358 1,240 3,797 1,275 1,013 3,519 4,164 Breast cancer(c50) 568 1,246 2, , Prostate Cancer(C61) , ,530 Colorectal cancer(c18:c20) , ,089 1,445 Lymphoid and haematopoietic cancer(c81:c96) , ,049 Trachea, bronchial and lung cancer(c33:c34) Malignant melanoma(c43) Uterine cancer(c54:c55) Renal pelvis, ureter, bladder and urethra cancer(c65:c68.0) Kidney cancer(c64) Ovarian cancer(c56) Pancreatic cancer (C25) Oesophageal cancer(c15) Brain Cancer(C71) Stomach cancer(c16) Liver cancer(c22) Mesothelioma(C45) Thyroid cancer(c73) Tongue cancer(c01:c02) Other connective and soft tissue cancer(c49) Total Other cancers 462 1,163 2, ,804 2,109 Total Cancers 1,958 6,504 17,861 5,864 1,230 16,432 16,985 Female Male 8
9 Table 3.2: Numbers of the 20 most common incident cancers by year of diagnosis 2006 to 2010 (recruitment period) Other malignant skin cancer(c44) 2,656 1,467 1, Breast cancer(c50) 1, Prostate Cancer(C61) 1, Colorectal cancer(c18:c20) Lymphoid and haematopoietic cancer(c81:c96) Trachea, bronchial and lung cancer(c33:c34) Malignant melanoma(c43) Uterine cancer(c54:c55) Renal pelvis, ureter, bladder and urethra cancer(c65:c68.0) Kidney cancer(c64) Ovarian cancer(c56) Pancreatic cancer (C25) Oesophageal cancer(c15) Brain Cancer(C71) Stomach cancer(c16) Liver cancer(c22) Mesothelioma(C45) Thyroid cancer(c73) Tongue cancer(c01:c02) Other connective and soft tissue cancer(c49) Total of top 20 8,911 4,881 5,173 4,816 4, Other Cancers 1, Total ,663 6,002 5,693 5,
10 4. Data on prevalent cancers Figure 4.1: Numbers of the 20 most common prevalent cancers (ICD), diagnosed before date of recruitment Other malignant skin cancer(c44) Breast cancer(c50) Prostate Cancer(C61) Colorectal cancer(c18:c20) Lymphoid and haematopoietic cancer(c81:c96) Malignant melanoma(c43) Cervical cancer(c53) Uterine cancer(c54:c55) Testicular cancer(c62) Ovarian cancer(c56) Renal pelvis, ureter, bladder and urethra cancer(c65:c68.0) Kidney cancer(c64) Thyroid cancer(c73) Trachea, bronchial and lung cancer(c33:c34) Other connective and soft tissue cancer(c49) Laryngeal cancer(c32) Tongue cancer(c01:c02) Stomach cancer(c16) Brain Cancer(C71) Oesophageal cancer(c15) ,098 2,318 2,159 2,068 9,323 9, no.participants 10
11 Table 4.1: Numbers of the 20 most common prevalent cancers by age group and sex Type <40 years 40 to <50 50 to <60 60 to <70 Missing Female Male years years years age Other malignant skin cancer(c44) 573 2,069 4,075 3, ,040 4,894 Breast cancer(c50) 657 2,955 4,216 1, , Prostate Cancer(C61) ,190 1, ,098 Colorectal cancer(c18:c20) , ,333 Lymphoid and haematopoietic cancer(c81:c96) ,212 Malignant melanoma(c43) , Cervical cancer(c53) Uterine cancer(c54:c55) Testicular cancer(c62) Ovarian cancer(c56) Renal pelvis, ureter, bladder and urethra cancer(c65:c68.0) Kidney cancer(c64) Thyroid cancer(c73) Trachea, bronchial and lung cancer(c33:c34) Other connective and soft tissue cancer(c49) Laryngeal cancer(c32) Tongue cancer(c01:c02) Stomach cancer(c16) Brain Cancer(C71) Oesophageal cancer(c15) Top 20 total 3,772 8,081 13,812 9, ,216 13,726 Other cancers 4,253 2,565 2,540 1, ,538 2,173 Total Cancers 8,025 10,646 16,352 10, ,754 15,899 11
12 Table 4.2: Numbers of the 20 most common prevalent cancers by year of diagnosis < to < to < to < to recruitment Other malignant skin cancer(c44) ,301 7,024 Breast cancer(c50) ,950 5,679 Prostate Cancer(C61) ,959 Colorectal cancer(c18:c20) ,676 Lymphoid and haematopoietic cancer(c81:c96) ,298 Malignant melanoma(c43) ,144 Cervical cancer(c53) Uterine cancer(c54:c55) Testicular cancer(c62) Ovarian cancer(c56) Renal pelvis, ureter, bladder and urethra cancer(c65:c68.0) Kidney cancer(c64) Thyroid cancer(c73) Trachea, bronchial and lung cancer(c33:c34) Other connective and soft tissue cancer(c49) Laryngeal cancer(c32) Tongue cancer(c01:c02) Stomach cancer(c16) Brain Cancer(C71) Oesophageal cancer(c15) Total top ,738 8,649 22,960 Other cancers ,292 3,334 4,611 Total 26 1,043 5,030 11,983 27,571 12
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