Figure S1. Comparison of fasting plasma lipoprotein levels between males (n=108) and females (n=130). Box plots represent the quartiles distribution
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1 Figure S1. Comparison of fasting plasma lipoprotein levels between males (n=108) and females (n=130). Box plots represent the quartiles distribution of A: total cholesterol (TC); B: low-density lipoprotein cholesterol (LDL-C); C: triglycerides (TG); D: high-density lipoprotein cholesterol (HDL-C). *P<0.05; ***P<0.001, Student's t-test. ns: not significant.
2 Figure S2. Comparison of fasting plasma lipoprotein levels between different age groups of study participants (G1: 14 22, G2: 23 31, G3: 32 40, G4:41 49, G5: 50 58, and G5: 59 years). Box plots represent the quartiles distribution of A: total cholesterol (TC); B: low-density lipoprotein cholesterol (LDL-C); C: triglycerides (TG), D: high-density lipoprotein cholesterol (HDL-C). **P<0.01; ***P<0.001, Student's t-test. ns: not significant.
3 Figure S3. Age trends of medians in study population for A, TC (total cholesterol); LDL-C (low-density lipoprotein cholesterol); HDL-C (high-density lipoprotein cholesterol), and B, TG (triglycerides) in males and females.
4 Figure S4. Comparison of fasting plasma lipoprotein levels between urban and rural groups. Box plots represent the quartiles distribution of A: total cholesterol (TC); B: low-density lipoprotein cholesterol (LDL-C); C: triglycerides (TG); D: high-density lipoprotein cholesterol (HDL-C). ns: not significant (P>0.05, Student's t-test).
5 Figure S5. Distribution of fasting plasma lipoprotein levels between white-collar and bluecollar groups of study population. Box plots represent the quartiles distribution of A: total cholesterol (TC); B: low-density lipoprotein cholesterol (LDL-C); C: triglycerides (TG); D: highdensity lipoprotein cholesterol (HDL-C). ns: not significant (P>0.05, Student's t-test).
6 Figure S6. Comparison of fasting plasma lipoprotein levels between urban white-collar and urban blue-collar sub-groups of participants. Box plots represent the quartiles distribution of A: total cholesterol (TC); B: low-density lipoprotein cholesterol (LDL-C); C: triglycerides (TG); D: high-density lipoprotein cholesterol (HDL-C). ns: not significant (P>0.05, Student's t-test).
7 Figure S7. Comparison of fasting plasma lipoprotein levels between smokers and nonsmokers sub-groups of study population. Box plots represent the quartiles distribution of A: total cholesterol (TC); B: low-density lipoprotein cholesterol (LDL-C); C: triglycerides (TG); D: high-density lipoprotein cholesterol (HDL-C). P>0.05, Student's t-test. ns: not significant.
8 Figure S8. Effect of smoking status on stratification of the study population into plasma lipoprotein-based CHD-risk categories. Statistical significance was determined by z-test for two population proportions. (P>0.05).
9 Table S1. Clinical and metabolic characteristics of the study population. Parameter Mean ± SD Range Age (years) ± Weight (kg) ± Height (cm) ± BMI (kg/m 2 ) ± BMR (cal/day) ± Body Fat (%) ± Total body fat mass (kg) ± Waist circumference (cm) ± Wrist (cm) ± Waist-to-hip ratio 0.87 ± Waist-to-height ratio 0.52 ± Systolic BP (mmhg) ± Diastolic BP (mmhg) ± Fasting glucose (mg/dl) n= ± TC (mg/dl) ± LDL-C (mg/dl) ± HDL-C (mg/dl) ± VLDL-C (mg/dl) ± TG (mg/dl) ± Non-HDL-C (mg/dl) ± TC/HDL-C 4.26 ± TG/HDL-C 3.75 ± LDL/HDL-C 2.62 ± Non-HDL/HDL-C 3.26 ± Male:Female ratio 54:65 Smokers (%) 12.6 Data are reported as means±sd except for smokers' percentage and male:female ratio. TC: total cholesterol; TG: triglycerides; LDL-C: low-density lipoprotein cholesterol; HDL-C: highdensity lipoprotein cholesterol; BMI: body mass index; BMR: basal metabolic rate; BP: blood pressure.
10 Table S2. Clinical and metabolic characteristics of the male participants. Parameter Mean ± SD Range Age (years) ± Weight (kg) ± Height (cm) ± BMI, kg/m ± BMR (cal/day) ± Body fat (%) ± Total body fat mass (kg) ± Waist circumference (cm) ± Wrist (cm) ± Waist-to-hip ratio 0.92 ± Waist-to-height ratio 0.53 ± Systolic BP (mmhg) ± Diastolic BP (mmhg) ± Fasting glucose (mg/dl) n= ± TC (mg/dl) ± LDL-C (mg/dl) ± HDL-C (mg/dl) ± VLDL-C (mg/dl) ± TG (mg/dl) ± Non-HDL-C (mg/dl) ± TC/HDL-C 4.46 ± TG/HDL-C 4.56 ± LDL/HDL-C 2.72 ± Non-HDL/HDL-C 3.46 ± Smokers (%) Data are reported as means±sd except smokers' percentage. TC: total cholesterol; TG: triglycerides; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; BMI: body mass index; BMR: basal metabolic rate; BP: blood pressure.
11 Table S3. Clinical and metabolic characteristics of the female participants. Parameter Mean ± SD Range Age (years) ± Weight (kg) ± Height (cm) ± BMI, kg/m ± BMR (cal/day) ± Body fat (%) ± Total body fat mass (kg) ± Waist circumference (cm) ± Wrist (cm) ± Waist-to-hip ratio 0.82 ± Waist-to-height ratio 0.51 ± Systolic BP (mmhg) ± Diastolic BP (mmhg) ± Fasting glucose (mg/dl) n= ± TC (mg/dl) ± LDL-C (mg/dl) ± HDL-C (mg/dl) ± VLDL-C (mg/dl) ± TG (mg/dl) ± Non-HDL-C (mg/dl) ± TC/HDL-C 4.09 ± TG/HDL-C 3.07 ± LDL/HDL-C 2.53 ± Non-HDL/HDL-C 3.09 ± Smokers (%) 0 Data are reported as means±sd except smokers' percentage. TC: total cholesterol; TG: triglycerides; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; BMI: body mass index; BMR: basal metabolic rate; BP: blood pressure.
12 Table S4. Classification of the study population into different occupational classes. Occupational Groups No. of Participants White collar Managers 4 Professionals 5 Technicians and associate professionals 7 Clerical support workers 6 Service and sales workers 2 Students* 196 Blue collar Skilled agricultural, forestry and fishery workers 36 Craft and related trades workers 8 Plant and machine operators, and Assemblers 10 Elementary occupations 15 Armed forces occupations 4 *Students were classified as white-collar participants. Table S5. Effect of gender on stratification of the study population into plasma lipoproteinbased coronary heart disease (CHD) risk-categories. Plasma lipoprotein Plasma lipoprotein CHD risk category Population % (n) P value Males (n=108) Females (n=130) Cholesterol Desirable (86) (103) Borderline high (14) (15) High 7.41 (8) 9.23 (12) LDL-C Optimal (66) (76) Near optimal/above optimal (18) (24) Borderline high 14.8 (16) (17) High 4.63 (5) 3.08 (4) Very High 2.8 (3) 6.92 (9) HDL-C Low (51) (43) * Average (42) (66) High (15) (21) TG Normal (59) (103) 0.0* Borderline high (21) (16) High 25 (27) 7.69 (10) * Very High 0.93 (1) 0.77 (1) Data are reported as percent (n). *P<0.05, z-test for 2 population proportions. LDL-C: lowdensity lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; TG: triglycerides.
13 Table S6. Effect of age on stratification of the study population into plasma lipoprotein-based coronary heart disease (CHD) risk-categories. Plasma Plasma lipoprotein Population % (n) lipoprotein CHD risk category G1 (n=71) G2 (n=47) G3 (n=29) G4 (n=39) G5 (n=26) G6 (n=26) Cholesterol Desirable (62) (39) (20) (27) (19) (22) Borderline high 4.22 (3) (5) (4) (9) (5) (3) High 8.45 (6) 6.39 (3) (5) 7.69 (3) 7.69 (2) 3.85 (1) LDL- C Optimal (49) (34)* (9) (20) 42.31(11)* (19) Near optimal/above 16.9 (12) 8.51 (4) (7) (8) (9)* (3) optimal Borderline high 4.23 (3) (5)* 31.03(9) (8) (4) (3) High 4.22 (3) 4.25 (2) 3.45 (1) 5.13 (2) 0 (0) 3.85 (1) Very High 5.63 (4) 4.25 (2) (3) 2.56 (1) 7.69 (2) 0 (0) HDL- C Low (26) (14)* (16) (17) (11) (9) Average (35) (20) (8)* (21) (10) (15) High 14.1 (10) (13) (5)* 2.56 (1)* (5) 7.69 (2) TG Normal (62) (36) (20) (20) (12) (12) Borderline high 9.86 (7) 8.51 (4) (4) (7) (8) (7) High 2.82 (2)* (7) (5) 28.2 (11) (6) (6) Very High 0 (0) 0 (0) 0 (0) 2.56 (1) 0 (0) 3.85 (1) Age groups in years: G1 (14 22), G2 (23 31), G3 (32 40), G4 (41 49), G5 (50 58), and G6 ( 59). *P<0.05, comparisons were made between the consecutive age groups (z-test for 2 population proportions). LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; TG: triglycerides. Table S7. Prevalence of various isolated and mixed dyslipidemias in the study population. Type of Dyslipidemia Percentage (proportion) At least one lipid-fraction affected 62.6 (149/238) Isolated dyslipidemia TC>200 0 (0/238) LDL-C (2/238) HDL-C < (41/238) TG (28/238) Mixed dyslipidemia TC>200, LDL-C (12/238) TC>200, HDL-C <40 0 (0/238) TC>200, TG (5/238) LDL-C 130, HDL-C < (6/238) LDL-C 130, TG (0/238) TG 150, HDL-C < (20/238) TG 150, HDL-C <40, LDL-C (3/238) HDL-C <40, LDL-C 130, TC> (12/238) HDL-C <40, TC>200, TG (1/238) TG 150, LDL-C 130, TC> (9/238) HDL-C <40, LDL-C 130, TC>200, TG (10/238) TC: total cholesterol; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; TG: triglyceride.
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