Ag Nano Particles. Mapping overlay of HaCaT cells incubated with Ag NP sample: Red maps each pixel matching the spectral curves of Ag NP

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3 Ag Nano Particles Nano-scale Microscopy & Hyperspectral Imaging Ag Nano Particles Family of Spectral Curves HaCaT cells incubated with Ag NP Hyperspectral Scanned Image: 40x objective Mapping overlay of HaCaT cells incubated with Ag NP sample: Red maps each pixel matching the spectral curves of Ag NP

4 Mapping Anthrax and Bac. globigii on unknown sample Bac. anthracis Sterne Strain Spectral curves of both Bacilli captured and stored in the spectral library Bac. globigii Spectra of both Bacilli mapped on sample. Spectral signature of Bacillus anthracis Sterne and Bacillus globigii captured and mapped on an unknown sample. Confirmed presence of Bacillus anthracis Sterne mapped in red but not Bacillus globigii on the sample image.

5 Bio Polymeric -Nano-particles- Nano-scale Microscopy & Hyperspectral Imaging Spectral Family of Curves: Bio Polymeric nano-particles Epithelial cell incubated with Bio polymeric nano-particles and scanned with CytoViva HSI Mapping overlay of cells incubated with Polymeric nano-particles: Red maps each pixel matching the spectra of Polymer nano-particles

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7 Cancer drug mapped on cancer cells Nano-scale Microscopy & Hyperspectral Imaging Spectral curves from Doxorubicin coated on a slide Hyperspectral scan of live cancer cells containing Doxorubicin Overlay image: red maps the areas of the live cancer cells containing Doxorubicin spectral signatures

8 Fe 2 O 3 Nano Particles -Magnetic Imaging- Nano-scale Microscopy & Hyperspectral Imaging Fe 2 O 3 Nano Particles Family of Spectral Curves Macrophage cells incubated with Fe 2 O 3 NP Hyperspectral Scanned Image: 40x objective Mapping overlay of Macrophage cells incubated with Fe 2 O 3 NP: Red maps each pixel matching the spectra of Fe 2 O 3 NP

9 Spectral Mapping of 127nm Liposomes w/ PEG Coating Microscopic Hyperspectral Imaging CytoViva-Hyperspectral Imaging (HSI) integrates the high S/N illumination from CytoViva optical microscope with Hyperspectral Imaging spectrophotometer and Image Analysis software as a tool for nanotech and biomedical research. Liposome in Soln. 127 nm Liposome Optical scan of 127 nm Liposomes coated with 10 nm PEG coating Spectral Imaging Process: Optical Field of View scanned with CytoViva- HSI Spectral map 127 nm Liposome Liposome spectra Spectra of the Liposome and PEG Coating stored in reference library PEG Coating spectra Software identifies every CCD-Pixel creating spectral map Spectra of Liposome and PEG coating mapped on the original Optical scan For more information contact us: info@cytoviva.com

10 Liposomes Binding to Cells -Targeted Drug Delivery- Nano-scale Microscopy & Hyperspectral Imaging Family of Spectral Profiles from Liposome sample Cells incubated with Liposomes Mapping overlay of cells incubated with Liposome: Red maps each pixel matching the spectra of liposome

11 Micro-fluidics Chamber used for polymer composite studies PET Microfiber Composite Nano-scale Hyperspectral Imaging Coated TiO 2 Polymer Modifier Polystyrene-Bead Q-Dot Confirm the spectral composition of PET microfiber composite containing 605nm Q-DOTs, coated TiO 2, labeled polystyrene beads, and polymer modifier.

12 SWCNT in Macrophage Nano-scale Microscopy & Hyperspectral Imaging SWCNT Spectral Curves Macrophage with SWCNT imaged with CytoViva-Hyperspectral Imaging System Macrophage with SWCNT Mapped in RED The RED areas highlight only those pixels matching the spectral profiles of SWCNT curves selected from the software s spectral library. Contact us: info@cytoviva.com

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