FORMULATION RELEASE STUDY OF SOME IMPORTANT DRUGS FROM SUPPOSITORY
|
|
- Alicia Lawson
- 5 years ago
- Views:
Transcription
1 FORMULATION RELEASE STUDY OF SOME IMPORTANT DRUGS FROM SUPPOSITORY Mohammed Younus Ali*, Sadat Ali JJT University, Churu-Bisau Road, Jhunjhunu Rajasthan ABSTRACT: The purpose of this study was to formulate and study the release of drugs namely atenolol a antihypertensive and aceclofenac a non steroidalanti inflammatory drug from suppositories prepared using hydrogenated vegetable oil as a hydrophobic polymer and in combination with beeswax as hardening agent, propylene glycol as plasticizer and propyl paraben as preservative. Suppositories were prepared using fusion method the prepared suppositories were studied for various parameters viz., physical appearance, assay and dissolution studies. The dissolution studies suggest that suppositories of atenolol prepared using hydrogenated vegetable oil along with 7.5% beeswax has released upto 99% of atenolol in 150 minutes and followed zero order kinetics ( r=0.9902) and release mechanism was found to be diffusion controlled which is evident by Higuchi s equation (r=0.9598), where as the suppositories of aceclofenac prepared utilizing hydrogenated vegetable oil along with 7.5% of beeswax has released 99.18% of aceclofenac with 240 minutes sustain release that might due to effect of hydrophobic hydrogenate vegetable oil and followed zero order kinetics (r=0.9927) and the release was by diffusion mechanism according to Higuchi s equation (r=0.9783). FT-IR studies showed that there was no drug excipient interaction. Key Words: Atenolol, Aceclofenac, Zero order, Diffusion Introduction: Oral administration is the route of choice in the daily practice of pharmacotherapy. However, oral route becomes impractical in certain cases such as nausea, vomiting or convulsion. In such conditions the rectal route may provide a practical alternative. The human rectum represents a body cavity in which drug is can be easily introduced and retained well. Rectal route is also good for drugs that irritates gastro intestinal mucosa [1], avoiding first pass effect in the liver and in Ideal suppository would be easy to administer and with good patient compliance and remain at the administered site [2] avoiding first pass effect in the liver and in gastro intestinal tract. Conventional suppositories are semisolid dosage form [3] The rectal route is much preferred in pediatric and geriatric patient with difficulties in swallowing solid oral dosage form [4].In pursuit to the above findings the suppositories are proven to be a convenient dosage form in the treatment of chronic health disorders Corresponding Author* Mohammed Younus Ali 33 P a g e
2 such as rheumatism and cardiovascular diseases specially among the aged patients. In the present work suppositories of atenolol and aceclofenac are prepared. Atenolol [5] is an antihypertensive drug used in the management of hypertension, angina pectoris and emergency treatment of cardiac arrhythmias, but its oral bioavailability is only 50% because of its poor absorption from gastrointestinal tract, on the other hand the drug has a few gastro intestinal side effects such as nausea, vomiting and diarrhea. Aceclofenac [6] (ACL) is a new generation NSAID widely used in the long term therapy of various rheumatic disorders and is associated with gastro-intestinal disorders such as gastric irritation and ulceration which can be prevented by administering through rectum in the form of solid suppositories. In the present study, rectal suppositories of Atenolol and Aceclofenac were developed by using hydrophobic polymeric bases like hydrogenated vegetable oil using propylene glycol as plasticizer and beeswax as hardening agent. Fat like bases are used for water-soluble drugs and a hydrophilic base for a drug, insoluble in water [7]. Material and Methods Aceclofenac and Atenolol was a gift sample from Glenmark Pharmaceutical Nasik, Hydrogenated vegetable oil was procured, and all the other materials was procured from SD Fine chemicals and was of analytical grade. Preparation of Suppositories: Before preparing the suppositories it is essential to calculate the displacement value for fatty base. The displacement values were found to be 1.23gm and 1.58 gm for atenolol and aceclofenac respectively. The pre calibrated suppository moulds were used for the preparation of suppositories. The suppositories were prepared employing fusion (Pour Moulding ) method [8].hydrogenated vegetable oil was melted in a beaker the drug either atenolol or aceclofenac was dispersed in the melted base with continuous stirring until homogeneous dispersion is obtained, add the propylene glycol and propyl paraben with stirring. The mass was fed in to the precalibrated mould under cooled conditions and kept until the suppository hardens and then removed from the mould, wrapped in a aluminium foil and stored at refrigeration. The composition of suppositories are given in table-1 Evaluation of Suppositories: The physical appearance of the suppositories was examined by cutting the suppository longitudinally and examining by naked eyes for any defects. The uniformity of weight was determined as per I.P specification [9]. The drug content assay was carried out using methanol for both atenolol and aceclofeanac at 276 and nm respectively using spectrophotometer In vitro Dissolution Studies: In vitro Dissolution studies of were carried out in USP XIII tablet dissolution test apparatus I (Electrolab TDT 06N) Employing a basket at 50 rpm using 900 ml of buffer [Ph. 7.4] at 37±0.5ºC as dissolution medium. One suppository was used in each test. At predetermined time intervals 5ml of the sample were withdrawn by means of a syringe fitted 34 P a g e
3 with a prefilter. The volume withdrawn at each interval was replaced with same quantity of fresh dissolution medium maintained at 37±0.5ºC. The samples were analyzed for drug release by measuring the absorbance using UV-visible spectrophotometer after suitable dissolutions. All the studies were conducted in triplicate. Rectal suppositories of Atenolol and Aceclofenac were formulated by fusion method using hydrogenated vegetable oil ( AT 0 - AT 3 and AC 1 - AC 5 ), as base, beeswax for increasing the melting point of hydrogenated vegetable oil and propylene glycol as plasticizer. The prepared suppositories were evaluated for appearance, drug content uniformity, in vitro dissolution and drug excipient interaction. All the suppositories were free from pits, fissures and cracks. The longitudinal section of the suppositories was opaque and uniform in appearance, indicating complete and even distribution of drug in the base. The drug content was found to be in the range of 95.52% to 99.5%, which is within the acceptable limits. The low standard deviation values indicate drug content was uniform in the suppositories prepared. The suppositories prepared with hydrogenated vegetable oils alone were soft with low melting below 37 o C, to increase the hardness beeswax was added in the formulation. In vitro dissolution studies on the formulated hydrogenated vegetable oil- beeswax suppositories (( AT 0 - AT 3 and AC 1 - AC 5 ), were carried out in ph 7.4 phosphate buffer and the various dissolution parameters, viz., percent drug dissolved, t 50% and t 70% are shown in table-2and dissolution profile are depicted in Figures1 and 2. This data shows that hydrogenated vegetable oilbeeswax suppositories of atenolol have released up to 99.20% ( AT 2 containing 7.5% bees wax) of the drug in 150 min whereas that of Aceclofenac hydrogenated vegetable oil-beeswax suppositories have released up to 99.18% (AC 4, which contains 7.5% w/w bees wax) of the drug in 4 hours. In case of suppositories prepared with hydrogenated vegetable oilbeeswax suppository base, the release rate decreases as the concentration of the beeswax increases; this might be due to the increase in melting time. Drug Release Kinetics: The in vitro drug release data was subjected to goodness of fit test by linear regression analysis, according to firstorder kinetic equations, zero order, Higuchi and Peppas models to determine the mechanism of drug release. The regression coefficient r values for Higuchi s equation range from to indicating that the drug release is by diffusion mechanism, and those of n values of Peppas equation range from to As per the n values of Peppa s equation the prepared suppositories have shown non-fickian (AT 1, ATVS 2, AT 3 n>0.45), and super case-ii transport (AT 0 n>1.0) release mechanism. The super case-ii transport release mechanism may attribute to burst effect displayed by these formulations. All the formulations except AT 3 have shown zero order drug release kinetics. Similarly for Aceclofenac suppositories the data was subjected to goodness of fit, The 35 P a g e
4 regression coefficient r values for Higuchi s equation range from to indicating that the drug release is by diffusion mechanism, and those of n values of Peppas equation range from to As per the n values of Peppas equation, the prepared suppositories have shown Fickian (AC 4 n<0.45), non-fickian (AC 3, AC >n>0.45) and super case-ii (AC 1 and AC 2, n>1.0) release mechanism. The super case-ii release mechanism may be attributed to burst- effect displayed by these formulations, this, in turn, might be because of high concentration of beeswax ( 8.75 to 10 % w/w). The formulation AC 3 containing 7.5% w/w beeswax in hydrogenated vegetable oil has displayed zero-order release rate (r = ), and it has released % ACL within 4 hours. All the formulations have shown zeroorder drug release kinetics. FT-IR: FT-IR was done to evaluate interactions between the drug and polymer and was found that there was no drug-excipient interaction. Conclusion: it can be stated that fatty bases retard the release of water insoluble drug (Aceclofenac) and enhances the release the water soluble drug (Atenolol) from the prepared suppositories. Reference: 1. Taha EI, Zaghloul AA, Samyb AM, Al-Saidan S, Kassem AA and Khan MA. Bioavailability assessment of salbutamol sulfate suppositories in human volunteers. Int. J. Pharm 2004; 279: Young J P, Chul SY, Hak MK, Jong DR, Yu KO, Chong KK and Han GC. Effect of sodium chloride on the release, absorption and safety of diclofenac sodium delivered by poloxamer gel. Int. J. Pharm 2003; 263: Larry JC and Herbert AL. Suppositories. In: LachmanL,Liberman HA and Kanig JC. (eds.) The Theory and Practice of Industrial Pharmacy. 3 rd ed. Varghese Publishing House, Mumbai, 1987, pp Lawrence HB. Remington. The Science and Practice of Pharmacy.19 th ed. Mack Publishing House, New York, 1995, pp Sweetman SC. Martindale. The Complete Drug Reference.34 th ed. Pharmaceutical Press.London, 2005, pp Sweetman SC. Martindale, 2005, The Complete Drug Reference. 34 th ed. Pharmaceutical Press. London, 2005, pp Hermann TW. Recent research on bioavailability of drugs from suppositories.int. J. Pharm. 1995; 123: Carter SJ. Cooper and Gun s Dispensing for Pharmaceutical Students.12 th ed. CBS Publishers, New Delhi. 2008, pp Indian Pharmacopoeia. 4 th ed. Controller of Publications, Ministry of Health and Family Welfare, Govt of India, New Delhi, 1996, pp P a g e
5 Table-1 Composition of Suppositories (10) Formulation Code S.N Ingredients AT 0 AT 1 AT 2 AT 3 AC 1 AC 2 AC 3 AC 4 AC 5 1 Hydrogenated Vegetable oil (gm) 2 Beeswax(gm) Propylene Glycol (gm) 4 Propyl Paraben(gm) 5 Distill Water Aceclofenac Atenolol Table-2 Atenolol and Aceclofenac Release Data from suppositories Formulation Code Time (mins) Cummulative % amount drug release t 50% (mins) t 70% (mins) Zero order r Higuchi s Equation r Peppa s Equation n AT 0(CONTROL) ± AT ± AT ± AT ± AC ± AC ± AC ± AC ± AC ± P a g e
6 Cummulative Percent Drug Release Cummulative percent drug release Time (mins) AT0 AT1 AT2 AT3 AC1 AC2 AC3 AC4 AC5 Figure-1 Cumulative percent Drug release versus time (ZERO ORDER) Plots Square root of time AT0 AT1 AT2 AT3 AC1 AC2 AC3 AC4 AC5 Figure-2 Cumulative percent Drug Released V/s Square root of Time (HIGUCHI'S) PLOT 38 P a g e
Design and evaluation of rectal drug delivery systems of non-steroidal anti-inflammatory drug
Swamy et al., International Current Pharmaceutical Journal 2012, 1(7): 165-170 http://www.icpjonline.com/documents/vol1issue7/02.pdf International Current Pharmaceutical Journal ORIGINAL RESEARCH ARTICLE
More informationFormulation and evaluation of immediate release salbutamol sulphate
5 Formulation, optimization and evaluation of immediate release layer of salbutamol sulphate Salbutamol is moderately selective beta (2)-receptor agonist similar in structure to terbutaline and widely
More informationEffect of Polymer Concentration and Viscosity Grade on Atenolol Release from Gastric Floating Drug Delivery Systems
Effect of Polymer Concentration and Viscosity Grade on Atenolol Release from Gastric Floating Drug Delivery Systems 1 1 1 2 U.V. Bhosale*, V. Kusum Devi, Nimisha Jain and P.V. Swamy 1 Al-Ameen College
More informationGlobal College of Pharmacy, Kahnpur Khui, Tehsil Anandpur Sahib, Distt.- Ropar, Punjab, India
IJPSR (2012), Vol. 3, Issue 09 (Research Article) Received on 19 May, 2012; received in revised form 25 June, 2012; accepted 27 August, 2012 IN-VITRO EVALUATION OF TWO MARKETED BRANDS OF PARACETAMOL TABLETS
More informationFormulation and Development of Sustained Release Tablets of Valsartan Sodium
INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACY, BIOLOGY AND CHEMISTRY Research Article Formulation and Development of Sustained Release Tablets of Valsartan Sodium G. Sandeep * and A. Navya Department of
More informationSuppository Chapter Content
10 min SUPPOSITORY Suppository Chapter Content 1. Suppositories and Factors Affecting Drug Absorption 2. Ideal Suppository and Different Types of Bases 3. Methods of Suppository Manufacturing Suppository
More informationA Comparative Evaluation of Cross Linked Starch Urea-A New Polymer and Other Known Polymers for Controlled Release of Diclofenac
Asian Journal of Chemistry Vol. 22, No. 6 (2010), 4239-4244 A Comparative Evaluation of Cross Linked Starch Urea-A New Polymer and Other Known Polymers for Controlled Release of Diclofenac K.P.R. CHOWDARY*
More informationVolume: 2: Issue-3: July-Sept ISSN FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL
Volume: 2: Issue-3: July-Sept -2011 ISSN 0976-4550 FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL Ajaykumar Patil*, Ashish Pohane, Ramya Darbar, Sharanya Koutika, Alekhya
More information7. SUMMARY, CONCLUSION AND RECOMMENDATIONS
211 7. SUMMARY, CONCLUSION AND RECOMMENDATIONS Drug absorption from the gastro intestinal tract can be limited by various factors with the most common one being poor aqueous solubility and poor permeability
More informationFORMULATION AND EVALUATION OF ACECLOFENAC SODIUM BILAYER SUSTAINED RELEASE TABLETS
International Journal of ChemTech Research CODEN( USA): IJCRGG ISSN : 0974-4290 Vol.1, No.4, pp 1381-1385, Oct-Dec 2009 FORMULATION AND EVALUATION OF ACECLOFENAC SODIUM BILAYER SUSTAINED RELEASE TABLETS
More informationFORMULATION AND EVALUATION OF NATURAL PALM OIL BASED DICLOFENAC SODIUM SUPPOSITORIES
IJPSR (2013), Vol. 4, Issue 2 (Research Article) Received on 24 October, 2012; received in revised form, 27 November, 2012; accepted, 26 January, 2013 FORMULATION AND EVALUATION OF NATURAL PALM OIL BASED
More informationFORMULATION AND CHARACTERIZATION OF TELMISATAN SOLID DISPERSIONS
International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 974-434 Vol.2, No.1, pp 341-347, Jan-Mar 1 FORMULATION AND CHARACTERIZATION OF TELMISATAN SOLID DISPERSIONS Kothawade S. N. 1 *, Kadam
More informationFormulation and evaluation of sublingual tablets of lisinopril
Journal of GROVER Scientific & Industrial AGARWAL: Research FORMULATION AND EVALUATION OF SUBLINGUAL TABLETS OF LISINOPRIL Vol. 71, June 2012, pp. 413-417 413 Formulation and evaluation of sublingual tablets
More informationPatel B et al. IRJP 1 (1)
INTERNATIONAL RESEARCH JOURNAL OF PHARMACY Available online http://www.irjponline.com Research Article IMPROVEMENT OF SOLUBILITY OF CINNARIZINE BY USING SOLID DISPERSION TECHNIQUE Patel Bipin*, Patel Jayvadan,
More informationDEVELOPMENT AND IN VITRO EVALUATION OF SUSTAINED RELEASE FLOATING MATRIX TABLETS OF METFORMIN HYDROCHLORIDE
ISSN: 0975-8232 IJPSR (2010), Vol. 1, Issue 8 (Research article) Received 11 April, 2010; received in revised form 17 June, 2010; accepted 13 July, 2010 DEVELOPMENT AND IN VITRO EVALUATION OF SUSTAINED
More informationJournal of Chemical and Pharmaceutical Research
Available on line www.jocpr.com Journal of Chemical and Pharmaceutical Research ISSN No: 0975-7384 CODEN(USA): JCPRC5 J. Chem. Pharm. Res., 2011, 3(3):159-164 Studies on formulation and in vitro evaluation
More informationENHANCEMENT OF SOLUBILITY OF BICALUTAMIDE DRUG USING SOLID DISPERSION TECHNIQUE
PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES ENHANCEMENT OF SOLUBILITY OF BICALUTAMIDE DRUG USING SOLID DISPERSION TECHNIQUE Kantilal B. Narkhede *1, R. B. Laware 2, Y. P.
More informationEVALUATION OF EFFERVESCENT FLOATING TABLETS. 6.7 Mathematical model fitting of obtained drug release data
EVALUATION OF EFFERVESCENT FLOATING TABLETS 6.1 Technological characteristics of floating tablets 6.2 Fourier transform infrared spectroscopy (FT-IR) 6.3 Differential scanning calorimetry (DSC) 6.4 In
More informationFormulation and In-vitro Evaluation of Chewable Tablets of Montelukast Sodium
Available online on www.ijddt.com International Journal of Drug Delivery Technology 214; (3); 98-13 Research Article ISSN: 97 441 Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast
More informationInternational Journal of Medicine and Pharmaceutical Research
International Journal of Medicine and Pharmaceutical Research Journal Home Page: www.pharmaresearchlibrary.com/ijmpr Research Article Open Access Formulation and Evaluation of Gastroretentive Floating
More informationSTUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS
Int. J. Chem. Sci.: 10(4), 2012, 1934-1942 ISSN 0972-768X www.sadgurupublications.com STUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS K. VENUGOPAL * and K. P. R. CHOWDARY a Nirmala College
More informationDesign and Evaluation of Atenolol Floating Drug Delivery System
Available online on www.ijcpr.com International Journal of Current Pharmaceutical Review and Research, 4(1), 1-26 Research Article ISSN: 976-822X Design and Evaluation of Atenolol Floating Drug Delivery
More informationAvailable Online through Research Article
ISSN: 0975-766X Available Online through Research Article www.ijptonline.com DESIGN AND EVALUATION OF GASTRORETENTIVE TABLETS FOR CONTROLLED DELIVERY OF NORFLOXOCIN Ganesh Kumar Gudas*, Subal Debnath,
More informationDesign and Characterisation of Sustained Release Microcapsules of Salbutamol Sulphate
International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 0974-4304 Vol.2, No.2, pp 1144-1149, April-June 2010 Design and Characterisation of Sustained Release Microcapsules of Salbutamol
More informationA FACTORIAL STUDY ON THE ENHANCEMENT OF DISSOLUTION RATE OF KETOPROFEN BY SOLID DISPERSION IN COMBINED CARRIERS
Research Article A FACTORIAL STUDY ON THE ENHANCEMENT OF DISSOLUTION RATE OF KETOPROFEN BY SOLID DISPERSION IN COMBINED CARRIERS K. P. R. Chowdary *, Tanniru Adinarayana, T. Vijay, Mercy. R. Prabhakhar
More informationSTABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS
Int. J. Chem. Sci.: 8(1), 2010, 405-414 STABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS V. L. NARASAIAH, T. KARTHIK KUMAR, D. SRINIVAS, K. SOWMYA, P. L. PRAVALLIKA and Sk. Md. MOBEEN
More informationAsian Journal of Pharmacy and Life Science ISSN Vol. 2 (2), July-Sept,2012
STUDIES ON EFFECT OF SUPERDISINTEGRANTS ON ETORICOXIB TABLET FORMULATIONS Chowdary K. P. R 1, Venugopal. K *2 1 College of Pharmaceutical Sciences, Andhra University, Vishakapattanam. 2 * Nirmala college
More informationFormulation and Evaluation
Chapter-5 Formulation and Evaluation 5.1 OBJECTIVE After successful taste masking and solubility enhancement of drugs in preliminary studies, by using Mannitol Solid Dispersion, next step includes the
More informationUniversity of Sulaimani School of Pharmacy Dept. of Pharmaceutics Third level - Second semester
University of Sulaimani School of Pharmacy Dept. of Pharmaceutics Third level - Second semester 5/21/2017 Pharmaceutical Compounding, Dr. rer. nat. Rebaz Ali 1 Outlines Why rectal or vaginal route? Suppository
More informationFORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE COLON TARGETED TABLETS
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article FORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE COLON TARGETED TABLETS G. Subba Rao
More informationA study on the effects of different surfactants on Ethylcellulose microspheres
International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 0974-4304 Vol.1, No.4, pp 966-971, Oct-Dec 2009 A study on the effects of different surfactants on Ethylcellulose microspheres Lalduhsanga
More informationDr.N.Damodharan Professor and head Department of pharmaceutics SRM college of pharmacy
Dr.N.Damodharan Professor and head Department of pharmaceutics SRM college of pharmacy Suppositories are solid dosage forms intended for insertion into body orifices where they melt, soften, or dissolve
More informationDESIGN AND EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF FLURBIPROFEN
Int. J. Chem. Sci.: 10(4), 2012, 2199-2208 ISSN 0972-768X www.sadgurupublications.com DESIGN AND EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF FLURBIPROFEN K. V. R. N. S. RAMESH *, B. HEMA KIRNAMAYI
More informationFABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS
Int. J. Chem. Sci.: 7(4), 2009, 2555-2560 FABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS HINDUSTAN ABDUL AHAD *, B. PRADEEP KUMAR, C.
More informationPreparation and Evaluation of Silymarin Controlled Release Tablets Prepared Using Natural Gums
1368 International Journal of Pharmaceutical Sciences and Nanotechnology Volume 4 Issue 1 April-June 211 Research Paper International Journal of Pharmaceutical Sciences and Nanotechnology Volume 4 Issue
More informationPreparation and Evaluation of Ethylene Vinyl Acetate Copolymer Coated Microcapsules of Glipizide for Controlled Release
Asian Journal of Chemistry Vol. 21, No. 8 (2009), 5838-5842 Preparation and Evaluation of Ethylene Vinyl Acetate Copolymer Coated Microcapsules of Glipizide for Controlled Release K.P.R. CHOWDARY* and
More informationPreparation and Evaluation of Ethyl Cellulose Coated Microcapsules of Carbamazepine for Controlled Release
Asian Journal of Chemistry Vol. 20, No. 8 (2008), 5901-5907 Preparation and Evaluation of Ethyl Cellulose Coated Microcapsules of Carbamazepine for Controlled Release K.P.R. CHOWDARY* and MALLURU SUBBA
More informationskim milk as carrier by kneading method. They were evaluated for percentage yield, drug content, FT-IR
Available Online through ISSN: 0975-766X CODEN: IJPTFI Research Article www.ijptonline.com ENHANCEMENT OF SOLUBILITY & DISSOLUTION RATE OF LAMOTRIGINE BY KNEADING METHOD Gadhave M.V*, Mahakal A. J., Gaikwad
More informationCOMPARATIVE IN VITRO EVALUATION OF COMMERCIALLY AVAILABLE PANTOPRAZOLE DELAYED RELEASE TABLETS
343 P a g e International Standard Serial Number (ISSN): 2319-8141 International Journal of Universal Pharmacy and Bio Sciences 3(4): July-August 2014 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY AND BIO
More informationDesign and In-vitro Evaluation of Silymarin Bilayer Tablets
CODEN (USA)-IJPRUR, e-issn: 2348-6465 International Journal of Pharma Research and Health Sciences Available online at www.pharmahealthsciences.net Original Article Design and In-vitro Evaluation of Silymarin
More informationComparative Dissolution Study of Glipizide by Solid Dispersion Technique
Comparative Dissolution Study of Glipizide by Solid Dispersion Technique Dehghan M H G 1, Saifee M 1, Hanwate R M 2 1 Y.B.Chavan College of Pharmacy,Dr. Rafiq Zakaria campus, Aurangabad-431001, Maharashtra,
More informationFormulation and Evaluation of Gastroretentive Dosage form of Ciprofloxacin Hydrochloride.
Available online on www.ijcpr.com International Journal of Current Pharmaceutical Review and Research, 3(4), 105-109 Research Article ISSN: 0976-822X Formulation and Evaluation of Gastroretentive Dosage
More informationFORMULATION AND EVALUATION OF PIROXICAM AND CELECOXIB TABLETS EMPLOYING PROSOLVE BY DIRECT COMPRESSION METHOD
Int. J. Chem. Sci.: 6(3), 2008, 1270-1275 FORMULATION AND EVALUATION OF PIROXICAM AND CELECOXIB TABLETS EMPLOYING PROSOLVE BY DIRECT COMPRESSION METHOD K. P. R. CHOWDARY, P. TRIPURA SUNDARI and K. SURYA
More informationPharmaceutical Studies on Formulation and Evaluation of Sustained Release Tablets Containing Certain Drugs
Mansoura University Faculty of Pharmacy Department of Pharmaceutics Pharmaceutical Studies on Formulation and Evaluation of Sustained Release Tablets Containing Certain Drugs Thesis presented by Ali Saeed
More informationKarnataka Department of Pharmaceutical Technology, H.K.E. Society s College of Pharmacy, Gulbarga, Karnataka ABSTRACT KEYWORDS:
335 P a g e International Standard Serial Number (ISSN): 2319-8141 International Journal of Universal Pharmacy and Bio Sciences 4(6): November-December 2015 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY
More informationFormulation and Evaluation of Oral disintegrated tablets of Alfuzosin Hydrochloride using superdisintegrants
ISSN: 2231-3354 Received on: 13-11-2011 Revised on: 18:11:2011 Accepted on: 22-11-2011 Formulation and Evaluation of Oral disintegrated tablets of Alfuzosin Hydrochloride using superdisintegrants Leela
More informationFACTORIAL STUDIES ON THE EFFECTS OF HYDROXY PROPYL β- CYCLODEXTRIN AND POLOXAMER 407 ON THE SOLUBILITY AND DISSOLUTION RATE OF BCS CLASS II DRUGS
JChrDD Vol 2 Issue 2 2011: 89-93 ISSN 2249-6785 Journal of Chronotherapy and Drug Delivery Received: August 06, 2011 Accepted: Sep 12, 2011 Original Research Paper FACTORIAL STUDIES ON THE EFFECTS OF HYDROXY
More informationJournal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp , Oct -Dec 2011
ISSN: 223-7346 Research Article Journal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp -394-43, Oct -Dec 211 FORMULATION AND INVITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF GLIMEPIRIDE
More informationInternational Journal of Innovative Pharmaceutical Sciences and Research
International Journal of Innovative Pharmaceutical Sciences and Research www.ijipsr.com FORMULATION AND EVALUATION OF ph INDEPENDENT TABLETS OF ATENOLOL 1 S. Mahaboob Basha*, 2 N. Srinivas Department of
More informationMODULATION OF GASTROINTESTINAL TRANSIT TIME OF SALBUTAMOL SULPHATE BY FLOATING APPROCHES
Pooja et al Journal of Drug Delivery & Therapeutics; 213, 3(3), 37-41 37 Available online at http://jddtonline.info RESEARCH ARTICLE MODULATION OF GASTROINTESTINAL TRANSIT TIME OF SALBUTAMOL SULPHATE BY
More informationEFFECT OF PVP ON CYCLODEXTRIN COMPLEXATION OF EFAVIRENZ FOR ENHANCING ITS SOLUBILITY AND DISSOLUTION RATE
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article EFFECT OF PVP ON CYCLODEXTRIN COMPLEXATION OF EFAVIRENZ FOR ENHANCING ITS SOLUBILITY AND DISSOLUTION
More informationFORMULATION AND EVALUATION OF BILAYERED TABLET OF METFORMIN HYDROCHLORIDE AND PIOGLITAZONE HYDROCHLORIDE
Academic Sciences International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 975-1491 Vol 4, Suppl 5, 212 FORMULATION AND EVALUATION OF BILAYERED TABLET OF METFORMIN HYDROCHLORIDE AND PIOGLITAZONE
More informationFeasibility of using natural gums for development of sustained release matrix tablet of itopride
Available online at wwwscholarsresearchlibrarycom Scholars Research Library Der Pharmacia Lettre, 215, 7 (3):114-123 (http://scholarsresearchlibrarycom/archivehtml) ISSN 975-571 USA CODEN: DPLEB4 Feasibility
More informationBiowaiver Study on Prednisolone Tablets 5 mg in Three Different Brands. Marketed in Sudan. Safaa Mohamed *, Tilal Elsaman
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2017, 9 [4]:8-114 [http://scholarsresearchlibrary.com/archive.html] ISSN 0975-5071 USA CODEN: DPLEB4
More informationInternational Journal of Research in Pharmaceutical and Nano Sciences Journal homepage:
Research Article CODEN: IJRPJK ISSN: 2319 9563 International Journal of Research in Pharmaceutical and Nano Sciences Journal homepage: www.ijrpns.com COMPARARISSION OF SOLUBILITY IMPROVEMENT OF CEFIXIME
More informationFormulation Development and In-Vitro Evaluation of Gastroretentive Floating tablets of Atenolol
Formulation Development and In-Vitro Evaluation of Gastroretentive Floating tablets of Atenolol K.Viveksarathi, K.Kannan*, S.Selvamuthu Kumar, R.Manavalan Department of Pharmacy, Faculty of Engineering
More informationFormulation and Evaluation of Bilayer Tablet by Wet Granulation
ABSTRACT: Formulation and Evaluation of Bilayer Tablet by Wet Granulation Nishith Patel 1, Kanu R Patel 2, Rakesh kumar Jat 3 1 Research Scholar, JJT University, Jhunjhunu, Rajasthan, India 2 Asso. Professor,
More informationResearch Article Derivative Spectrophotometric Method for Estimation of Metformin Hydrochloride in Bulk Drug and Dosage Form
Research Article Derivative Spectrophotometric Method for Estimation of Metformin Hydrochloride in Bulk Drug and Dosage Form Gowekar NM, Lawande YS*, Jadhav DP, Hase RS and Savita N. Gowekar Department
More informationJournal of Chemical and Pharmaceutical Research
Available on line www.jocpr.com Journal of Chemical and Pharmaceutical Research ISSN No: 975-7384 CODEN(USA): JCPRC5 J. Chem. Pharm. Res., 211, 3(2):786-791 Development and optimization of colon targeted
More informationChemate and Chowdary, IJPSR, 2012; Vol. 3(7): ISSN:
IJPSR (2012), Vol. 3, Issue 07 (Research Article) Received on 18 March, 2012; received in revised form 25 April, 2012; accepted 22 June, 2012 A FACTORIAL STUDY ON ENHANCEMENT OF SOLUBILITY AND DISSOLUTION
More informationOptimization of valsartan tablet formulation by 2 3 factorial design
Research Article ISSN: 0974-6943 K. P. R. Chowdary et al. / Journal of Pharmacy Research 2014,8(9, Available online through http://jprsolutions.info Optimization of valsartan tablet formulation by 2 3
More informationAsian Journal of Research in Biological and Pharmaceutical Sciences
Research Article ISSN: 2349 4492 Asian Journal of Research in Biological and Pharmaceutical Sciences Journal home page: www.ajrbps.com APPLICATION OF FACTORIAL DESIGN AND OPTIMIZATION OF GLIMEPIRIDE SUSTAINED
More informationIN-VITRO RELEASE STUDY OF IBUPROFEN FROM DIFFERENT TOPICAL FORMULATIONS
IN-VITRO RELEASE STUDY OF IBUPROFEN FROM DIFFERENT TOPICAL FORMULATIONS Riyaz Md. Sakhiyani *, Pasha Mohamed Irshad and Mondal Md. Sahidullah M.M.U College of Pharmacy, K.K Doddi, Ramadevera Betta Road,
More informationFunctional Excipients for Suppository Applications
Functional Excipients for Suppository Applications Skin Delivery Platform 2016 1 The Skin Delivery Platform Major areas of activity are in 4 pillars PLATFORM : SKIN DELIVERY Dermal Drug Delivery Mildness
More informationDEVELOPMENT AND CHARACTERIZATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM OF A POORLY WATER SOLUBLE DRUG USING NATURAL OIL
Acta Poloniae Pharmaceutica ñ Drug Research, Vol. 69 No. 4 pp. 713ñ717, 2012 ISSN 0001-6837 Polish Pharmaceutical Society PHARMACEUTICAL TECHNOLOGY DEVELOPMENT AND CHARACTERIZATION OF SELF EMULSIFYING
More informationOPTIMIZATION OF CONTROLLED RELEASE GASTRORETENTIVE BUOYANT TABLET WITH XANTHAN GUM AND POLYOX WSR 1105
Digest Journal of Nanomaterials and Biostructures Vol. 9, No. 3, July September 2014, p. 1077-1084 OPTIMIZATION OF CONTROLLED RELEASE GASTRORETENTIVE BUOYANT TABLET WITH XANTHAN GUM AND POLYOX WSR 1105
More informationA STUDY ON SUITABILITY OF NIMESULIDE-BETACYCLODEXTRIN COMPLEX IN ORAL AND TOPICAL DOSAGE FORMS
International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 1, Suppl 1, Nov.-Dec. 2009 Research Article A STUDY ON SUITABILITY OF NIMESULIDE-BETACYCLODEXTRIN COMPLEX IN ORAL AND TOPICAL DOSAGE
More informationCHAPTER VI FACTORIAL STUDIES ON THE EFFECTS OF CYCLODEXTRINS AND SOLUTOL HS15 ON THE SOLUBILITY AND DISSOLUTION RATE OF EFAVIRENZ AND RITONAVIR
CHAPTER VI FACTORIAL STUDIES ON THE EFFECTS OF CYCLODEXTRINS AND SOLUTOL HS15 ON THE SOLUBILITY AND DISSOLUTION RATE OF EFAVIRENZ AND RITONAVIR Efavirenz and ritonavir, two widely prescribed anti retroviral
More informationENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF NIMESULIDE BY CYCLODEXTRINS, POLOXAMER AND PVP
Int. J. Chem. Sci.: 9(2), 20, 637-646 ISSN 0972-768X www.sadgurupublications.com ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF NIMESULIDE BY CYCLODEXTRINS, POLOXAMER AND PVP K. P. R. CHOWDARY *, K.
More informationDesign and development of fast Melting Tablets of Terbutaline Sulphate
Design and development of fast Melting Tablets of Terbutaline Sulphate Mathew T and Agrawal S Swami Vivekanand College of Pharmacy, Khandwa Road, Indore (MP), INDIA Available online at: www.isca.in (Received
More informationFORMULATION AND EVALUATION OF VALSARTAN TABLETS EMPLOYING CYCLODEXTRIN-POLOXAMER 407-PVP K30 INCLUSION COMPLEXES
Int. J. Chem. Sci.: 10(1), 2012, 297-305 ISSN 0972-768X www.sadgurupublications.com FORMULATION AND EVALUATION OF VALSARTAN TABLETS EMPLOYING CYCLODEXTRIN-POLOXAMER 407-PVP K30 INCLUSION COMPLEXES K. P.
More informationVenkateswara Rao et.al Indian Journal of Research in Pharmacy and Biotechnology ISSN: (Print) ISSN: (Online)
Design and development of Metformin hydrochloride Tried sustained release tablets Venkateswara Rao T 1 *, Bhadramma N 1, Raghukiran CVS 2 and Madubabu K 3 Bapatla College of Pharmacy, Bapatla, Guntur-522101
More informationFormulation Development of Aceclofenac Tablets Employing Starch Phosphate -A New Modified Starch
Abstract K.P.R. Chowdary et al. / International Journal of Pharma Sciences and Research (IJPSR) Formulation Development of Aceclofenac Tablets Employing Starch Phosphate -A New Modified Starch K.P.R. Chowdary*,
More informationFormulation and evaluation of oral dispersible tablets of aripiprazole
IJPAR Vol.6 Issue 2 April - June -17 Journal Home page: ISSN:23-2831 Research article Open Access Formulation and evaluation of oral dispersible tablets of aripiprazole A.Madhusudhan Reddy*, P.Srinivasababu,
More informationCompliance. Should you have any questions, please contact Behnaz Almasi, Associate Scientific Liaison ( or
Extended-Release Tablets Type of Posting Revision Bulletin Posting Date 30 Mar 2018 Official Date 01 Apr 2018 Expert Committee Chemical Medicines Monographs 3 Reason for Revision Compliance In accordance
More informationThe objective of the present investigation is to design and evaluate controlled release tablets of carvedilol, employing
Research Article Preparation and evaluation of controlled release tablets of carvedilol M L Varahala Setti, J Vijaya Ratna Division of Pharmaceutical Technology, University College of Pharmaceutical Sciences,
More informationThis PDF is available for free download
Research Paper Formulation Strategy for Low Absorption Window Antihypertensive Agent M. J. QURESHI, J. ALI*, ALKA AHUJA AND SANJULA BABOOTA Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard,
More informationEvaluation of Ethyl Cellulose as Microencapsulating Agent for Controlled Release of Glimepiride
Asian Journal of Chemistry Vol. 20, No. 8 (2008), 5924-5930 Evaluation of Ethyl Cellulose as Microencapsulating Agent for Controlled Release of Glimepiride K.P.R. CHOWDARY* and SRINIVAS PANGULURI University
More informationComparative study of different solubility enhancement techniques on dissolution rate of zaltoprofen
World Journal of Pharmaceutical Sciences ISSN (Print): 2321-3310; ISSN (Online): 2321-3086 Published by Atom and Cell Publishers All Rights Reserved Available online at: http://www.wjpsonline.org/ Original
More informationThe Relevance of USP Methodology in the Development of a Verapamil Hydrochloride (240 mg) Extended Release Formulation
METHOCEL Premium Cellulose Ethers Application Data The Relevance of USP Methodology in the Development of a Verapamil Hydrochloride (240 mg) Extended Release Formulation INTRODUCTION Hydrophilic matrices
More informationDEVELOPMENT OF NON SODIUM EFFERVESCENT TABLET OF PARACETAMOL USING ARGININE CARBONATE
IJPSR (2013), Vol. 4, Issue 5 (Research Article) Received on 17 July, 2012; received in revised form, 23 February, 2013; accepted, 14 April, 2013 DEVELOPMENT OF NON SODIUM EFFERVESCENT TABLET OF PARACETAMOL
More information13. SUPPOSITORY Suppository Bases. The active substance is prepared in a suitable bases. An ideal suppository bases should carry:
13. SUPPOSITORY They are solid single-dose preparations whose shapes, volumes and consistencies are suitable for rectal administration. There are also such vaginal preparations in the treatment of local
More informationFormulation and evaluation of oro-dispersible tablets of lafutidine
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2015, 7 (5):226-235 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationJ Pharm Sci Bioscientific Res (4): ISSN NO
Development and Validation of Analytical Methods for Simultaneous Estimation of Pregabalin and Amitriptyline Hydrochloride in their Combined Marketed Dosage form ABSTRACT: Nikhilkumar Patel, Gurjit Kaur,
More informationStudy of Disintegrant Property of Moringa Oleifera Gum and its Comparison with other Superdisintegrants
International Journal of ChemTech Research CODEN( USA): IJCRGG ISSN : 0974-4290 Vol. 3, No.3, pp 1119-1124, July-Sept 2011 Study of Disintegrant Property of Moringa Oleifera Gum and its Comparison with
More informationRoutes of drug administration
Routes of drug administration Definition:- A route of administration in pharmacy is the path by which a drug is taken into the body. Classification:- The various routes of administrations are classified
More informationBahadur S. et al /J. Pharm. Sci. & Res. Vol.1(4), 2009,
Abstract: In the present work, we developed an effective mucoadhesive tablets of omeprazole(diomeprazole magnesium powder and omeprazole pellets) by direct punch method with excellent mucoadhesive force
More informationDESIGNING OF ORODISPERSIBLE TABLET OF DIETHYL CARBAMAZINE CITRATE FOR THE TREATMENT OF FILARIASIS
Volume: 2: Issue-4: Oct - Dec -2011 ISSN 0976-4550 DESIGNING OF ORODISPERSIBLE TABLET OF DIETHYL CARBAMAZINE CITRATE FOR THE TREATMENT OF FILARIASIS Chinmaya Keshari Sahoo* 1, Tanmaya Keshari Sahoo 2 and
More informationDEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF METOPROLOL SUCCINATE
Page224 Research Article Pharmaceutical Sciences DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF METOPROLOL SUCCINATE S. A. Pagar*, D.M.Shinkar 1, R.B.Saudagar 2 *,1 Department
More informationPreparation and Characterization of Candesartan Cilexetil Solid Lipid Nanoparticulate Capsules
Research Article Preparation and Characterization of Candesartan Cilexetil Solid Lipid Nanoparticulate Capsules *Surya Kiran Vuddisa, Subramanian S., Sindhu Raavi Department of Pharmaceutics, PSG College
More informationPREPARATION AND EVALUATION OF STARCH - PEG 1500 CO-PROCESSED EXCIPIENT AS A NEW DIRECTLY COMPRESSIBLE VEHICLE IN TABLET FORMULATIONS
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article PREPARATION AND EVALUATION OF STARCH - PEG 1500 CO-PROCESSED EXCIPIENT AS A NEW DIRECTLY COMPRESSIBLE
More informationFormulation and evaluation of sustained release atenolol
9 Formulation, optimization and evaluation of sustained release layer of atenolol Atenolol is a cardioselective β-blocker widely prescribed for asymptomatic condition such as hypertension. It is poorly
More informationLipid Based Matrices as Colonic Drug Delivery System for Diflunisal (In-vitro, In-vivo study)
Lipid Based Matrices as Colonic Drug Delivery System for Diflunisal (In-vitro, In-vivo study) Presented by Dr. AHMED ATEF DONIA, PH. D., Lecturer of Pharmaceutical Technology, Faculty of Pharmacy, Tanta
More informationFORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF FAMOTIDINE
FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF FAMOTIDINE Chandira. Margret R. *, Sahu Chandra Mohan and Jayakar B. Vinayaka Mission s College of Pharmacy Vinayaka Missions University,
More informationFormulation and evaluation of fast dissolving tablet of aceclofenac
International Journal of Drug Delivery 2 (2010) 93-97 http://www.arjournals.org/ijdd.html Research article ISSN: 0975-0215 Formulation and evaluation of fast dissolving tablet of aceclofenac Sudhir Bhardwaj
More informationDESIGN AND EVALUATION OF COST EFFECTIVE ORODISPERSIBLE TABLETS OF DIETHYLCARBAMAZINE CITRATE BY EFFERVESCENT METHOD
Vol.1(6), 010, 58-64 DESIGN AND EVALUATION OF COST EFFECTIVE ORODISPERSIBLE TABLETS OF DIETHYLCARBAMAZINE CITRATE BY EFFERVESCENT METHOD P. V. SWAMY*, S. N. GADA, S. B. SHIRSAND, M. B. KINAGI AND H. SHILPA
More informationA FACTORIAL STUDY ON ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF IBUPROFEN BY β CYCLODEXTRIN AND SOLUTOL HS15
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article A FACTORIAL STUDY ON ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF IBUPROFEN BY β CYCLODEXTRIN
More informationPreparation and Evaluation of Gastro Retentive Floating Tablets of Atorvastatin Calcium
Preparation and Evaluation of Gastro Retentive Floating Tablets of Atorvastatin Calcium Florida Sharmin 1, Md. Abdullah Al Masum 1, S. M. Ashraful Islam 1 and Md. Selim Reza 2 1 Department of Pharmacy,
More information1. Gastric Emptying Time Anatomically, a swallowed drug rapidly reaches the stomach. Eventually, the stomach empties its content in the small
Lecture-5 1. Gastric Emptying Time Anatomically, a swallowed drug rapidly reaches the stomach. Eventually, the stomach empties its content in the small intestine. Because the duodenum has the greatest
More informationIN VITRO DRUG RELEASE PROFILE OF ACECLOFENAC NIOSOMES FORMED WITH DIFFERENT RATIO S OF CHOLESTEROL USING SORBITAN ESTERS
Int. J. Chem. Sci.: 12(1), 2014, 237-247 ISSN 0972-768X www.sadgurupublications.com IN VITRO DRUG RELEASE PROFILE OF ACECLOFENAC NIOSOMES FORMED WITH DIFFERENT RATIO S OF CHOLESTEROL USING SORBITAN ESTERS
More information