Inflammation I. Dr. Nabila Hamdi MD, PhD
|
|
- Jody Owen
- 5 years ago
- Views:
Transcription
1 Inflammation I Dr. Nabila Hamdi MD, PhD
2 ULTGEN/examidx.htm 2
3 ILOs Distinguish between acute and chronic inflammation with respect to causes, nature of the inflammatory response, and tissue changes. Describe the sequence of vascular changes in acute inflammation and their purpose Know the mechanisms of increased vascular permeability Define the terms edema, transudate, and exudate Describe the steps involved in extravasation of leukocytes from the blood to the tissues. Know the steps at which selectins and integrins act. Describe the meaning and utility of chemotaxis. Understand the role that chemokines play in inflammation Describe the steps involved in phagocytosis and the role of opsonins Understand the mechanism of degradation in the phagolysosomes. Know the major effects of the chemical mediators of inflammation Distinguish between the different patterns of inflammation. Define an abscess. Know the cells involved in, and causes of chronic inflammation Understand the mechanism of granulomatous inflammation Describe the systemic manifestations of inflammation 3
4 Outline I. Overview Of Inflammation II. Acute Inflammation 1. Definition 2. Cardinal signs 3. Vascular changes 4. Cellular events 5. Chemical mediators 6. Outcomes III. Chronic Inflammation 1. Definition 2. Cells & mediators 3. Granulomatous Inflammation IV. Morphological Patterns of Acute and Chronic Inflammation V. Systemic Effects of Inflammation 4
5 Overview Inflammation is a protective response intended to eliminate the initial cause of cell injury as well as the necrotic cells and tissues resulting from the original insult. 5
6 Overview Players of Inflammation The goal of the inflammatory reaction is to bring cells and molecules of host defense (normally circulating in the blood) to the site of infection or tissue damage. These include blood leukocytes and plasma proteins, cells of vascular walls, and cells and extracellular matrix (ECM) of the surrounding connective tissue. 6
7 Acute Inflammation Definition: Acute inflammation is a rapid response to injury or microbes and other foreign substances that is designed to deliver leukocytes and plasma proteins to sites of injury. Stimuli: Infections (bacterial, viral, fungal, parasitic) Trauma (blunt and penetrating) Physical and chemical agents (thermal injury, e.g., burns or frostbite; irradiation or some environmental chemicals) Tissue necrosis (from any cause) Foreign bodies (splinters, dirt, sutures) Immune reactions (also called hypersensitivity reactions) 7
8 Acute Inflammation Heat (calor) redness (rubor) Swelling (tumor) Pain (dolor) loss of function (functio laesa) Cardinal Signs of Inflammation 8
9 Acute Inflammation The major local manifestations of acute inflammation, compared to normal, are: (1) Vascular dilation and increased blood flow (hyperemia), causing erythema and warmth (2) Extravasation and deposition of plasma fluid and proteins (edema) (3) Leukocyte (mainly neutrophil) emigration and accumulation in the site of injury Erythema Warmth Histamine Swelling 9
10 1. Vascular Changes Hyperemia Exudation Start of emigration Acute Inflammation 2. Cellular Events Margination Rolling Adhesion Transmigration Chemotaxis Activation Phagocytosis & killing 3. Chemical Mediators 10
11 Vascular Changes The mean colloid osmotic pressure is equal to the mean capillary pressure Fluid leaks out because of increased hydrostatic pressure or decreased osmotic pressure Formed in inflammation because vascular permeability increases as a result of increased interendothelial spaces Fluid accumulation in extravascular spaces is called edema; the fluid may be a transudate or exudate. Whereas exudates are typical of inflammation, transudates accumulate in various non-inflammatory conditions. 11
12 lung sounds - crackles (1).mp4 This chest X-ray shows an area of lung inflammation indicating the presence of pneumonia. Congestive heart failure with diffuse perihilair Pulmonary edema 12
13 Vascular Changes After transient vasoconstriction (lasting only for seconds), arteriolar vasodilation occurs, resulting in locally increased blood flow (hyperemia) and engorgement of the down-stream capillary beds. This vascular expansion is the cause of the redness (erythema) and warmth characteristically seen in acute inflammation. The increased volume of blood flow lead to a rise in intravascular hydrostatic pressure, resulting in movement of fluid from capillaries into the tissues (transudate). This fluid is essentially an ultrafiltrate of blood plasma and contains little protein. As the microvasculature becomes more permeable, protein-rich fluid moves into the extravascular tissues (exudate). This causes the red blood cells to become more concentrated, thereby increasing blood viscosity and slowing the circulation. 13
14 Cellular Events Photo by Bill Karkow. Publically donated by HAPS. This is a histology slide of a peripheral smear of blood. There are two neutrophils and scattered platelets. 14
15 Cellular Events Leukocyte Recruitment Stasis 1.Margination 4. Diapedesis/ Transmigration 7. Killing 6. Phagocytosis 5. Chemotaxis -Bacteria -Cytokines -Complement -Arachidonic acid metabolism The leukocytes first roll, then become activated and adhere to endothelium, then transmigrate across the endothelium, pierce the basement membrane, and migrate toward chemoattractants emanating from the source of injury. Different molecules play predominant roles in different steps of this process - selectins in rolling; chemokines in activating the neutrophils to increase avidity of integrins, integrins for stable adhesion. After extravasating from the blood, leukocytes migrate toward sites of infection or injury along a chemical gradient by a process called 15 chemotaxis.
16 Cellular Events Leukocyte Recruitment Margination: The process of leukocyte accumulation at the periphery of vessels. Leukocytes are pushed out of the central axial column and thus have a better opportunity to interact with lining endothelial cells, especially as stasis sets in. Rolling: leukocytes tumble on the endothelial surface, transiently sticking along the way. This weak and transient adhesion involved in rolling is mediated by the selectin family of adhesion molecules. Adhesion: firm adhesion of leukocytes to endothelial surfaces. This adhesion is mediated by integrins expressed on leukocyte cell surfaces interacting with their ligands on endothelial cells 16
17 Cellular Events Leukocyte Recruitment Transmigration: After being arrested on the endothelial surface, leukocytes migrate through the vessel wall primarily by squeezing between cells at intercellular junctions (diapedesis) Chemotaxis: After extravasation from the blood, leukocytes migrate toward sites of infection or injury along a chemical gradient. Both exogenous and endogenous substances can be chemotactic for leukocytes, including: (1) bacterial products (2) cytokines (3) components of the complement system, particularly C5a (4)products of the lipoxygenase pathway of arachidonic acid (AA) metabolism, particularly leukotriene B 4 (LTB 4 ). 17
18 Cellular Events Leukocyte Recruitment Leukocyte Response in Acute Inflammation: Extravasation Medicine, By Ernest In most forms of acute inflammation, neutrophils predominate in the inflammatory infiltrate during the first 6 to 24 hours. Why? Neutrophils are more numerous in the blood, they respond more rapidly to chemokines, and they may attach more firmly to the adhesion molecules that are rapidly induced on endothelial cells (selectins). In addition, after entering tissues, neutrophils are short-lived, they die by apoptosis and disappear within 24 to 48 hours. 18
19 Cellular Events Leukocyte Activation See next slide Different classes of cell surface receptors of leukocytes recognize different stimuli. The receptors initiate responses that mediate the functions of the leukocytes. Only some receptors are depicted. IFN-γ, interferon γ; LPS, lipopolysaccharide. 19
20 Cellular Events Leukocyte Activation oxidative burst Phagocytosis of a particle (e.g., a bacterium) involves (1) attachment and binding of the particle to receptors on the leukocyte surface, (2) engulfment and fusion of the phagocytic vacuole with granules (lysosomes), and (3) destruction of the ingested particle. inos, Inducible nitric oxide synthase; NO, nitric oxide; ROS, reactive oxygen species. 20
21 Cellular Events Leukocyte Activation Oxidative burst In leukocytes (mainly neutrophils and macrophages), the phagocyte oxidase (NADPH oxidase) in the phagosome membrane generates superoxide, which can be converted to other free radicals. Myeloperoxidase (MPO) in phagosomes also generates hypochlorite (hydroxy-halide radical) from ROS 21
22 Leukocyte Activation Phagocytosis (1) Recognition and attachment: Leukocytes bind and ingest most microorganisms and dead cells via specific surface receptors, which recognize either components of the microbes and dead cells, or host proteins, called opsonins, that coat microbes and target them for phagocytosis (a process called opsonization) (2) Engulfment: Pseudopods are extended around the object, eventually forming a phagocytic vacuole. The membrane of the vacuole then fuses with the membrane of a lysosomal granule, resulting in discharge of the granule's contents into the phagolysosome. (3) killing and degradation of the ingested material: The key steps in this reaction are the production of microbicidal substances within lysosomes and fusion of the lysosomes with phagosomes. The most important microbicidal substances are reactive oxygen species (ROS) and lysosomal enzymes (myeloperoxidase). Phagocytosis stimulates an oxidative burst characterized by a sudden increase in oxygen consumption, glycogen catabolism (glycogenolysis), increased glucose oxidation, and production of ROS. 22
23 Defects in Leukocyte Function Leukocyte Adhesion Deficiency (LAD) Defect in integrins/selectins Defects in microbicidal activity A genetic deficiency in one of the several components of the phagocyte oxidase responsible for generating ROS. In these patients, engulfment of bacteria does not result in activation of oxygen-dependent killing mechanisms. Defects in phagolysosome formation Impairment of the fusion of lysosomes with phagosomes 23
24 Summary of Vascular & Cellular Events Vasodilation is induced by chemical mediators such as histamine (described later), and is the cause of erythema and stasis of blood flow Increased vascular permeability allows plasma proteins and leukocytes to enter sites of infection or tissue damage; fluid leak through blood vessels results in edema Leukocytes are recruited from the blood into the extravascular tissue where infectious pathogens or damaged tissues may be located and are activated to perform their functions Leukocyte recruitment is a multi-step process consisting of loose attachment to and rolling on endothelium (mediated by selectins); firm attachment to endothelium (mediated by integrins); and migration through inter-endothelial spaces. Neutrophils predominate in the early inflammatory infiltrate and are later replaced by macrophages. Leukocytes can eliminate microbes and dead cells by phagocytosis, followed by their destruction in phagolysosomes. Destruction is caused by free radicals (ROS, NO) generated in activated leukocytes and lysosomal enzymes. Enzymes and ROS may be released into the extracellular environment, which may lead to damage of normal tissues. 24
25 1. Which cells are the key players in acute inflammatory response? 2. What are the cardinal signs of inflammation? 3. Which signs of inflammation are associated with histamine release? 4. What are the vascular changes that occur during acute inflammation? 5. What is the sequence of events in the cellular events of acute inflammation? 6. What is the definition of chemotaxis? 7. What is the mechanism of destruction of a bacteria by the neutrophils? 25
26 26
27 References ROBBINS Basic Pathology 8 th Edition Basic Pathology 7th Edition, by Kumar, Cotran and Robbins
1) Mononuclear phagocytes : 2) Regarding acute inflammation : 3) The epithelioid cells of follicular granulomas are :
Pathology Second 1) Mononuclear phagocytes : - Are the predominant cells in three day old wounds - Are common in liver, spleen and pancreasd - Produce fibroblast growth factor - Secrete interferon-g -
More informationINFLAMMATION: Cellular Functions
INFLAMMATION: Cellular Functions Sequence of Vascular Events 1. Vasodilation (increased blood flow) CALOR & RUBOR 2. Increased microvascular permeability: fluids into tissues TUMOR 3. Blood flow slows
More informationAcute and Chronic Inflammation Pathology 1 - Dr. Gary Mumaugh
Acute and Chronic Inflammation Pathology 1 - Dr. Gary Mumaugh Introduction Injurious stimuli cause a protective vascular connective tissue reaction called inflammation Acute and chronic forms o Inflame
More informationDisease causing organisms Resistance Immunity
Part 1 Disease causing organisms Resistance Immunity Bacteria Most common pathogens Anthrax Cholera Staphylococcus epidermidis bacteria Bacterial diseases Tuberculosis Cholera Bubonic Plague Tetanus Effects
More informationINFLAMMATION & REPAIR
INFLAMMATION & REPAIR Lecture 7 Chemical Mediators of Inflammation Winter 2013 Chelsea Martin Special thanks to Drs. Hanna and Forzan Course Outline i. Inflammation: Introduction and generalities (lecture
More informationProfessor Dr. Ali Hassan AL-Timimi MBChB, MSc, PhD Professor of Pathology
Acute Inflammation Acute inflammation is a rapid host response that serves to deliver leukocytes and plasma proteins, such as antibodies, to sites of infection or tissue injury. Acute inflammation has
More informationANATOMY OF THE IMMUNE SYSTEM
Immunity Learning objectives Explain what triggers an immune response and where in the body the immune response occurs. Understand how the immune system handles exogenous and endogenous antigen differently.
More informationINFLAMMATION. 5. Which are the main phases of inflammation in their "sequence": 1. Initiation, promotion, progression.
INFLAMMATION 1. What is inflammation: 1. Selective anti-infective pathological reaction. 2. Pathological process, typical for vascularized tissues. 3. Self-sustained pathological condition. 4. Disease
More informationInnate Immunity: Nonspecific Defenses of the Host
PowerPoint Lecture Presentations prepared by Bradley W. Christian, McLennan Community College C H A P T E R 16 Innate Immunity: Nonspecific Defenses of the Host Host Response to Disease Resistance- ability
More informationCh 12. Host Defenses I: Nonspecific Defenses
Ch 12 Host Defenses I: Nonspecific Defenses SLOs Differentiate between innate and adaptive immunity. Define and explain PRRs and PAMPs Differentiate physical from chemical factors, and list examples of
More informationModule 10 Innate Immunity
Module 10 Innate Immunity Chapter 16 Innate Immunity Lectures Lectures prepared prepared by by Christine HelmutL.Kae Case The Concept of Immunity Immunity: ability to protect against disease from microbes
More informationAcquired Immunity Cells are initially and require before they can work Responds to individual microbes
1 of 10 THE IMMUNE SYSTEM CHAPTER 43; PAGES 898 921 WHY DO WE NEED AN IMMUNE SYSTEM? It s a dirty, dirty world out there and we are vastly outnumbered Bacteria and parasites are everywhere The body has
More informationIndependent Study Guide The Innate Immune Response (Chapter 15)
Independent Study Guide The Innate Immune Response (Chapter 15) I. General types of immunity (Chapter 15 introduction) a. Innate i. inborn ii. pattern recognition b. Adaptive i. "learned" through exposure
More informationOverview of the immune system
Overview of the immune system Immune system Innate (nonspecific) 1 st line of defense Adaptive (specific) 2 nd line of defense Cellular components Humoral components Cellular components Humoral components
More informationPhysiology of Inflammation and Innate Immunity. สรช ย ศร ส มะ พ.บ., Ph.D. ภาคว ชาสร รว ทยา คณะแพทยศาสตร ศ ร ราชพยาบาล มหาว ทยาล ยมห ดล
Physiology of Inflammation and Innate Immunity สรช ย ศร ส มะ พ.บ., Ph.D. ภาคว ชาสร รว ทยา คณะแพทยศาสตร ศ ร ราชพยาบาล มหาว ทยาล ยมห ดล Overview Pathogens infectious agents capable of causing pathology,
More informationInnate Immunity. Connection Between Innate and Adaptive Immunity. Know Differences and Provide Examples Chapter 3. Antimicrobial peptide psoriasin
Know Differences and Provide Examples Chapter * Innate Immunity * kin and Epithelial Barriers * Antimicrobial peptide psoriasin -Activity against Gram (-) E. coli Connection Between Innate and Adaptive
More informationMIcro451 Immunology. Prof. Nagwa Mohamed Aref (Molecular Virologist & Immunology)
Host Defenses Overview and Nonspecific Defenses I-C MIcro451 Immunology Prof. Nagwa Mohamed Aref (Molecular Virologist & Immunology) Inflammation Phagocytosis Interferon Complement 14.2 The Second Line
More informationResisting infection. Cellular Defenses: Leukocytes. Chapter 16: Innate host defenses Phagocytosis Lymph Inflammation Complement
Resisting infection Chapter 16: Innate host defenses Lymph Inflammation Complement Bio 139 Dr. Amy Rogers Innate defenses (ch. 16) Physical & chemical barriers; cellular defenses; inflammation, fever;
More informationCell-Derived Inflammatory Mediators
Cell-Derived Inflammatory Mediators Introduction about chemical mediators in inflammation Mediators may be Cellular mediators cell-produced or cell-secreted derived from circulating inactive precursors,
More information1. Overview of Innate Immunity
Chapter 15: Innate Immunity 1. Overview of Innate Immunity 2. Inflammation & Phagocytosis 3. Antimicrobial Substances 1. Overview of Innate Immunity Chapter Reading pp. 449-456 The Body s Defenses The
More information16 Innate Immunity: M I C R O B I O L O G Y. Nonspecific Defenses of the Host. a n i n t r o d u c t i o n
ninth edition TORTORA FUNKE CASE M I C R O B I O L O G Y a n i n t r o d u c t i o n 16 Innate Immunity: Nonspecific Defenses of the Host PowerPoint Lecture Slide Presentation prepared by Christine L.
More informationChapter 14. Part 2. An Introduction to Host Defenses Innate Immunities
Chapter 14 Part 2 An Introduction to Host Defenses Innate Immunities Host defense mechanisms To protect the body against pathogens, the immune system relies on a multilevel network of physical barriers,
More information10. Which of the following immune cell is unable to phagocytose (a) neutrophils (b) eosinophils (c) macrophages (d) T-cells (e) monocytes
Chapter 2. Acute and chronic inflammation(6): 1. In acute inflammation, which events occur in the correct chronological order? (Remembered from 2000, 2004 exam.) p50 (a) transient vasoconstriction, stasis
More informationInnate Immunity. Chapter 3. Connection Between Innate and Adaptive Immunity. Know Differences and Provide Examples. Antimicrobial peptide psoriasin
Chapter Know Differences and Provide Examples Innate Immunity kin and Epithelial Barriers Antimicrobial peptide psoriasin -Activity against Gram (-) E. coli Connection Between Innate and Adaptive Immunity
More informationDefense mechanism against pathogens
Defense mechanism against pathogens Immune System What is immune system? Cells and organs within an animal s body that contribute to immune defenses against pathogens ( ) Bacteria -Major entry points ;open
More informationAcute Inflammation. Dr. G Mahendra Department of Pathology
Acute Inflammation Dr. G Mahendra Department of Pathology Inflammation Inflammation is a physiological response to tissue injury. Tissue injury Reaction/response of body Inflammation Inflammation is not
More informationACTIVATION OF T LYMPHOCYTES AND CELL MEDIATED IMMUNITY
ACTIVATION OF T LYMPHOCYTES AND CELL MEDIATED IMMUNITY The recognition of specific antigen by naïve T cell induces its own activation and effector phases. T helper cells recognize peptide antigens through
More informationINNATE IMMUNITY Non-Specific Immune Response. Physiology Unit 3
INNATE IMMUNITY Non-Specific Immune Response Physiology Unit 3 Protection Against Infection The body has several defenses to protect itself from getting an infection Skin Mucus membranes Serous membranes
More informationNEUTROPHIL, BASOPHIL, EOSINOPHIL, AND PLATELETS SURFACE RECEPTORS
LECTURE: 15 Title NEUTROPHIL, BASOPHIL, EOSINOPHIL, AND PLATELETS SURFACE RECEPTORS LEARNING OBJECTIVES: The student should be able to: Determine the relative percentages in blood for the various types
More informationCHAPTER THREE INFLAMMATION
CHAPTER THREE INFLAMMATION General Features Inflammation is defined as "the response of living vascularized tissues to harmful agents. It consists principally of vascular changes associated with leukocytes
More informationInnate Immunity Part I October 3, Dan Stetson
Innate Immunity Part I October 3, 2016 Dan Stetson stetson@uw.edu 441 Lecture #3 Slide 1 of 28 Three lectures on innate Immunity Part 1 (Today): Introduction and concepts Overview of main components and
More informationnumber Done by Corrected by Doctor
number 9 Done by Corrected by Doctor 1 Cellular Infiltration The movement of cells from their original region to a new region is called cellular infiltration. In our case, this applies to the cells that
More informationInnate Immunity. By Dr. Gouse Mohiddin Shaik
Innate Immunity By Dr. Gouse Mohiddin Shaik Types of immunity Immunity Innate / inborn Non-specific Acquired / adaptive Specific 3rd line of defense Physical barriers Skin, Saliva, Mucous, Stomach acid,
More informationBasic immunology. Lecture 9. Innate immunity: inflammation, leukocyte migration. Péter Engelmann
Basic immunology Lecture 9. Innate immunity: inflammation, leukocyte migration Péter Engelmann Different levels of the immune response Recognition molecules of innate immunity Initiation of local and systemic
More informationInnate vs Adaptive Response
General Immunology Innate vs Adaptive Response Innate- non-specific (4 types of barriers) anatomic- ato mechanical ca (skin), ph, mucous, normal flora Physiologic- temperature, ph, chemicals (lysozyme,
More informationTopics. Humoral Immune Response Part II Accessory cells Fc Receptors Opsonization and killing mechanisms of phagocytes NK, mast, eosynophils
Topics Humoral Immune Response Part II Accessory cells Fc Receptors Opsonization and killing mechanisms of phagocytes NK, mast, eosynophils Immune regulation Idiotypic network 2/15/2005 MICR 415 / 515
More informationInnate Immunity. Hathairat Thananchai, DPhil Department of Microbiology Faculty of Medicine Chiang Mai University 2 August 2016
Innate Immunity Hathairat Thananchai, DPhil Department of Microbiology Faculty of Medicine Chiang Mai University 2 August 2016 Objectives: Explain how innate immune system recognizes foreign substances
More information4b. Innate (nonspecific) Immunity
4b. Innate (nonspecific) Immunity Chapter 16: Innate (nonspecific) Immunity! Some terms:! Susceptibility: Lack of immunity to a disease.! Immunity: Ability to ward off disease.! Innate immunity: Defenses
More informationSubject Index. Bcl-2, apoptosis regulation Bone marrow, polymorphonuclear neutrophil release 24, 26
Subject Index A1, apoptosis regulation 217, 218 Adaptive immunity, polymorphonuclear neutrophil role 31 33 Angiogenesis cancer 178 endometrium remodeling 172 HIV Tat induction mechanism 176 inflammatory
More informationHYPERSENSITIVITY REACTIONS D R S H O AI B R AZ A
HYPERSENSITIVITY REACTIONS D R S H O AI B R AZ A HYPERSENSITIVITY REACTIONS Are exaggerated immune response upon antigenic stimulation Individuals who have been previously exposed to an antigen are said
More informationPatology. Inflammation (1) inflammations. Inflammations, regeneration, repair, and scarring. lecture 2
Patology Inflammations, regeneration, repair, and scarring lecture 2 prof dr hab. n. med. Andrzej Marszałek Inflammation (1) inflammations is a complex reaction to injurious agents such as microbes, chemical
More informationInflammation and Repair. Mousa Al-Abbadi, MD, FCAP,CPE, CPHQ,FIAC Professor of Pathology & Cytopathology University of Jordan College of Medicine
Inflammation and Repair Mousa Al-Abbadi, MD, FCAP,CPE, CPHQ,FIAC Professor of Pathology & Cytopathology University of Jordan College of Medicine Introduction 6 lectures inflammation 3 lectures repair;
More informationEndeavour College of Natural Health endeavour.edu.au
Endeavour College of Natural Health endeavour.edu.au BIOH122 Human Biological Science 2 Session 8 Immune System 1 Bioscience Department Endeavour College of Natural Health endeavour.edu.au Session Plan
More informationChapter 16 Innate Immunity: Nonspecific Defenses of the Host
Module 10 Chapter 16 Innate Immunity: Nonspecific Defenses of the Host The concept of immunity Immunity: ability to protect against from microbes and their o Aka, Susceptibility: vulnerability or lack
More informationLymphoid System: cells of the immune system. Answer Sheet
Lymphoid System: cells of the immune system Answer Sheet Q1 Which areas of the lymph node have most CD3 staining? A1 Most CD3 staining is present in the paracortex (T cell areas). This is towards the outside
More informationInnate Immunity. Natural or native immunity
Innate Immunity 1 Innate Immunity Natural or native immunity 2 When microbes enter in the body 3 Secondly, it also stimulates the adaptive immune system 4 Immunologic memory 5 Components of Innate Immunity
More informationHypersensitivity is the term used when an immune response results in exaggerated or inappropriate reactions harmful to the host.
Hypersensitivity is the term used when an immune response results in exaggerated or inappropriate reactions harmful to the host. Hypersensitivity vs. allergy Hypersensitivity reactions require a pre-sensitized
More informationNatural Defense Mechanisms
Color code: Important in red Extra in blue For team error adjustments, click here Natural Defense Mechanisms Objectives To know First (non-specific immunity) and second (adaptive immunity) lines of defense
More informationInnate Immunity. Natural or native immunity
Innate Immunity 1 Innate Immunity Natural or native immunity 2 When microbes enter in the body 3 Secondly, it also stimulates the adaptive immune system 4 Immunologic memory 5 Components of Innate Immunity
More information14.1 Overview of Host Defense Mechanisms. Barriers at the Portal of Entry: An Inborn First Line of Defense. The Lines of Defense
Chapter 14 An Introduction to Host Defenses and Innate Immunities* *Lecture notes are to be used as a study guide only and do not represent the comprehensive information you will need to know for the exams.
More informationA. Incorrect! The resistance that an individual acquires during life is known as specific immunity.
Microbiology - Problem Drill 13: Innate Immunity No. 1 of 10 1. Which type of immunity is attributed to the Anatomic, Physiologic, Phagocytic and inflammatory barriers? A. Specific Immunity B. Adaptive
More informationOverview of the Lymphoid System
Overview of the Lymphoid System The Lymphoid System Protects us against disease Lymphoid system cells respond to Environmental pathogens Toxins Abnormal body cells, such as cancers Overview of the Lymphoid
More informationThe recruitment of leukocytes and plasma proteins from the blood to sites of infection and tissue injury is called inflammation
The migration of a particular type of leukocyte into a restricted type of tissue, or a tissue with an ongoing infection or injury, is often called leukocyte homing, and the general process of leukocyte
More informationAnti-infectious Immunity
Anti-infectious Immunity innate immunity barrier structures Secretory molecules Phagocytes NK cells Anatomical barriers 1. Skin and mucosa barrier 2.hemo-Spinal Fluid barrier 3. placental barrier Phagocytic
More informationChapter 19: The Cardiovascular System: The Blood. Copyright 2009, John Wiley & Sons, Inc.
Chapter 19: The Cardiovascular System: The Blood Blood Liquid connective tissue 3 general functions 1. Transportation Gases, nutrients, hormones, waste products 2. Regulation ph, body temperature, osmotic
More informationHematopoiesis. Hematopoiesis. Hematopoiesis
Chapter. Cells and Organs of the Immune System Hematopoiesis Hematopoiesis- formation and development of WBC and RBC bone marrow. Hematopoietic stem cell- give rise to any blood cells (constant number,
More informationCell Mediated Immunity CELL MEDIATED IMMUNITY. Basic Elements of Cell Mediated Immunity (CMI) Antibody-dependent cell-mediated cytotoxicity (ADCC)
Chapter 16 CELL MEDIATED IMMUNITY Cell Mediated Immunity Also known as Cellular Immunity or CMI The effector phase T cells Specificity for immune recognition reactions TH provide cytokines CTLs do the
More informationLECTURE OUTLINE: CTP (Connective Tissues Proper) (Ordinary Connective Tissues)
LECTURE OUTLINE: CTP (Connective Tissues Proper) (Ordinary Connective Tissues) General Definition: Tissues composed of cells embedded in an extracellular (intercellular) matrix, consisting of ground substance
More informationConcept of Inflammation Definition? Cardinal Signs? Name of Scientists?
INFLAMMATION DR. M. TARIQ JAVED PROFESSOR DEPARTMENT OF PATHOLOGY FACULTY OF VETERINARY SCIENCE UNIVERSITY OF AGRICULTURE, FAISALABAD. LEARNING OBJECTIVES Definition of inflammation Overview of cells and
More informationNonspecific Defenses of the Host. Chapter 16
Nonspecific Defenses of the Host Chapter 16 I. Introduction: Overview of host defenses A. Resistance Ability to ward off disease through body defenses 1. Nonspecific All body defenses that protect one
More informationI. Lines of Defense Pathogen: Table 1: Types of Immune Mechanisms. Table 2: Innate Immunity: First Lines of Defense
I. Lines of Defense Pathogen: Table 1: Types of Immune Mechanisms Table 2: Innate Immunity: First Lines of Defense Innate Immunity involves nonspecific physical & chemical barriers that are adapted for
More informationIMMUNITY AND ANTIBODIES
IMMUNITY AND ANTIBODIES Stem cells in bone marrow differentiate into various blood cells Phagocytes attack alien cells A non-specific reaction Mast cells release histamine Histamine dilates capillaries,
More informationnumber Done by Corrected by Doctor Mousa Al-Abbadi
number 11 Done by Husam Abu-Awad Corrected by Muhammad Tarabieh Doctor Mousa Al-Abbadi The possible outcomes of an acute inflammation are the following: 1- A complete resolution in which the tissue returns
More informationFc receptors, phagocytosis role 128
Subject Index Adaptive immunity dependence on innate immunity 9, 10 evolution 10 Aging anti-inflammatory agents in counteraction 202 beneficial polymorphisms 199 201 definition 18, 189 innate immunity
More informationBACTERIAL PATHOGENESIS
BACTERIAL PATHOGENESIS A pathogen is a microorganism that is able to cause disease. Pathogenicity is the ability to produce disease in a host organism. Virulence a term which refers to the degree of pathogenicity
More informationTime course of immune response
Time course of immune response Route of entry Route of entry (cont.) Steps in infection Barriers to infection Mf receptors Facilitate engulfment Glucan, mannose Scavenger CD11b/CD18 Allows immediate response
More informationNonspecific Host Resistance. Counter attack (Specific Host Resistance) A. Nonspecific (Innate) Resistance (Page 362)
Pages 361-382 Nonspecific Host Resistance 1. Introduction A. Resistance i. Resistance by defense Resistance by alliance Counter attack (Specific Host Resistance) B. Susceptibility 2. Resistance A. Nonspecific
More informationImmunology. Prof. Nagwa Mohamed Aref (Molecular Virologist & Immunology)
Host Defenses Overview and Nonspecific Defenses I Immunology Prof. Nagwa Mohamed Aref (Molecular Virologist & Immunology) The Nature of Host Defenses 2 3 4 1st line of defense - intact skin mucous membranes
More informationThe Immune System: Innate and Adaptive Body Defenses Outline PART 1: INNATE DEFENSES 21.1 Surface barriers act as the first line of defense to keep
The Immune System: Innate and Adaptive Body Defenses Outline PART 1: INNATE DEFENSES 21.1 Surface barriers act as the first line of defense to keep invaders out of the body (pp. 772 773; Fig. 21.1; Table
More informationAcute Inflammation 2
Acute Inflammation 2 http://www.sciencedirect.com/science/article/pii/s1521689603001162 Recognition of Microbes and Dead Tissues Once leukocytes (neutrophils and monocytes) have been recruited to a site
More informationKinds of Resistance. Defense Mechanisms. Lec 7 (Ch14, 15): Nonspecific Immunity Host Defenses. 2 Major divisions: 3 Lines of Defense
Lec 7 (Ch14, 15): Nonspecific Immunity Host Defenses Topics - Defense Mechanisms (innate, acquired) - Systems (anatomic, immunological) - Non-specific immunity (general response) 1 Kinds of Resistance
More informationInnate Immunity: Nonspecific Defenses of the Host
PowerPoint Lecture Presentations prepared by Bradley W. Christian, McLennan Community College C H A P T E R 16 Innate Immunity: Nonspecific Defenses of the Host Big Picture: Immunity Big Picture: Immunity
More informationM.Sc. III Semester Biotechnology End Semester Examination, 2013 Model Answer LBTM: 302 Advanced Immunology
Code : AS-2246 M.Sc. III Semester Biotechnology End Semester Examination, 2013 Model Answer LBTM: 302 Advanced Immunology A. Select one correct option for each of the following questions:- 2X10=10 1. (b)
More informationImmune System AP SBI4UP
Immune System AP SBI4UP TYPES OF IMMUNITY INNATE IMMUNITY ACQUIRED IMMUNITY EXTERNAL DEFENCES INTERNAL DEFENCES HUMORAL RESPONSE Skin Phagocytic Cells CELL- MEDIATED RESPONSE Mucus layer Antimicrobial
More informationInflammation. (4 of 5)
Inflammation (4 of 5) What will we discuss today? Plasma protein derived mediators Anti-inflammatory mediators Morphologic patterns of acute inflammation Plasma protein derived mediators 3 systems: -Complement
More information2 االستاذ المساعد الدكتور خالد ياسين الزاملي \ مناعة \ المرحلة الثانية \ التحليالت المرضية \
Innate Immunity Innate immunity: is the resistance that an individual possesses by birth. Innate immunity may be classified as (a) individual immunity (b) racial immunity (c) species immunity. Factors
More informationChapter 2 (pages 22 33): Cells and Tissues of the Immune System. Prepared by Kristen Dazy, MD, Scripps Clinic Medical Group
Allergy and Immunology Review Corner: Cellular and Molecular Immunology, 8th Edition By Abul K. Abbas, MBBS; Andrew H. H. Lichtman, MD, PhD; and Shiv Pillai, MBBS, PhD. Chapter 2 (pages 22 33): Cells and
More informationHuman Immune Response. Part 1: innate immunity
Human Immune Response Part 1: innate immunity Our bodies are under constant attack from pathogens A pathogen is an organism that can cause disease Pathogens include: Bacteria Viruses Protists Fungi 6.3.1
More informationACUTE INFLAMMATORY RESPONSE EXTRAVASATION AND PHAGOCYTOSIS
General Pathology 18 ACUTE INFLAMMATORY RESPONSE EXTRAVASATION AND PHAGOCYTOSIS The accumulation of leukocytes is the most important feature of the inflammatory reaction. Leukocytes engulf and degrade
More informationImmunity. Chapter 38 Part 1
Immunity Chapter 38 Part 1 Impacts, Issues Frankie s Last Wish Infection with a common, sexually transmitted virus (HPV) causes most cervical cancers including the one that killed Frankie McCullogh 38.1
More informationLines of defense. Innate Immunity. Immunity. First line of defense: Skin and mucous membranes 11/20/2016. Chapter 16 BIO 220
Lines of defense Innate Immunity Chapter 16 BIO 220 Immunity The ability to ward off disease caused by microbes or their products and to protect against environmental agents such as pollen, chemicals,
More informationمحاضرة مناعت مدرس المادة :ا.م. هدى عبدالهادي علي النصراوي Immunity to Infectious Diseases
محاضرة مناعت مدرس المادة :ا.م. هدى عبدالهادي علي النصراوي Immunity to Infectious Diseases Immunity to infection depends on a combination of innate mechanisms (phagocytosis, complement, etc.) and antigen
More informationPathology MCQs. lipid. protein. glycogen. lipofuscin. water. Karyolysis. Cellular swelling. Involvement of a large number of cells
Pathology MCQs 1. In hypoxic cell injury, cell swelling occurs because of increased intracellular: lipid protein glycogen lipofuscin water 2. Which of the following is a feature of apoptosis? Karyolysis
More informationChapter Lymphatic Cells, Lymphatic Tissues, and Lymphatic Organs
Chapter 22.2 Lymphatic Cells, Lymphatic Tissues, and Lymphatic Organs Lymphatic Cells These are the cells that play a key roll in the structure and function of the immune system. We have already introduced
More informationInnate Immunity. Bởi: OpenStaxCollege
Innate Immunity Bởi: OpenStaxCollege The vertebrate, including human, immune system is a complex multilayered system for defending against external and internal threats to the integrity of the body. The
More informationCHAPTER 16: LYMPHATIC SYSTEM AND IMMUNITY OBJECTIVES. Transport dietary fat. Transport excess tissue fluid back to blood stream
CHAPTER 16: LYMPHATIC SYSTEM AND IMMUNITY OBJECTIVES 1. Name the organs that compose the lymphatic system and give three general functions performed by this system. Bone Marrow Control Disease Thymus Lymph
More informationAnatomy. Lymph: Tissue fluid that enters a lymphatic capillary (clear fluid that surrounds new piercings!)
Lymphatic System Anatomy Lymphatic vessels: meet up in capillaries of of tissues to collect extra water, and have an end point of meeting up with lymphatic ducts that empty fluid into large veins in the
More informationChapter 16/17: Immune system
Chapter 16/17: Immune system Lecture Chapter 16: Nonspecific defenses First line of defense Formed elements Second line of defense Complement system Chapter 17: Specific defenses Antibodies Humoral response
More informationChapter 13 Lymphatic and Immune Systems
The Chapter 13 Lymphatic and Immune Systems 1 The Lymphatic Vessels Lymphoid Organs Three functions contribute to homeostasis 1. Return excess tissue fluid to the bloodstream 2. Help defend the body against
More informationInnate Immunity. Hathairat Thananchai, DPhil Department of Microbiology Faculty of Medicine Chiang Mai University 25 July 2017
Innate Immunity Hathairat Thananchai, DPhil Department of Microbiology Faculty of Medicine Chiang Mai University 25 July 2017 Objectives: Explain how innate immune system recognizes foreign substances
More informationAll implants interact to some extent with the tissue environment in which they are placed.
Host reactions to biomaterials All implants interact to some extent with the tissue environment in which they are placed. 1 Host reactions to biomaterials Complications are largely based on biomaterial-tissue
More informationKinds of Resistance. Defense Mechanisms. Lec 7 (17): Innate Nonspecific Immunity Host Defenses. 2 Major divisions: 3 Lines of Defense
Lec 7 (17): Innate Nonspecific Immunity Host Defenses Topics - Defense Mechanisms (innate, acquired) - Systems (anatomic, immunological) - Non-specific immunity (general response) 1 Kinds of Resistance
More informationChapter Pages Transmission
Chapter 19.2 Pages 442-448 Transmission Immunity There are three lines of defense: 1 The skin and mucous membranes are a nonspecific barrier to infection. 2 Macrophages attack pathogens that enter the
More informationInnate Immunity. Jan 8 th Prof. dr. sc. Ivana Novak Nakir 1
Innate Immunity Jan 8 th 2018. Prof. dr. sc. Ivana Novak Nakir 1 Adaptive Innate 2 Immune system overview 1 st line of defense skin (2m 2 ) and mucosal membranes (~400m 2 ): physical barrier, lymphoid
More information3/28/2012. Immune System. Activation of Innate Immunity. Innate (non-specific) Immunity
Chapter 5 Outline Defense Mechansims Functions of B Lymphocytes Functions of T Lymphocytes Active and Passive Immunity Tumor Immunology Diseases Caused By Immune System Immune System Anatomy - Lymphoid
More informationT cell-mediated immunity
T cell-mediated immunity Overview For microbes within phagosomes in phagocytes.cd4+ T lymphocytes (TH1) Activate phagocyte by cytokines studies on Listeria monocytogenes For microbes infecting and replicating
More informationThe Lymphatic System. Innate Immunity
The Lymphatic System Innate Immunity 1 Types of Immunity Innate (non-specific) immunity Adaptive (specific) immunity The human body has several different ways that it defends itself against infection by
More informationThere are 2 major lines of defense: Non-specific (Innate Immunity) and. Specific. (Adaptive Immunity) Photo of macrophage cell
There are 2 major lines of defense: Non-specific (Innate Immunity) and Specific (Adaptive Immunity) Photo of macrophage cell Development of the Immune System ery pl neu mφ nk CD8 + CTL CD4 + thy TH1 mye
More information11/25/2017. THE IMMUNE SYSTEM Chapter 43 IMMUNITY INNATE IMMUNITY EXAMPLE IN INSECTS BARRIER DEFENSES INNATE IMMUNITY OF VERTEBRATES
THE IMMUNE SYSTEM Chapter 43 IMMUNITY INNATE IMMUNITY EXAMPLE IN INSECTS Exoskeleton made of chitin forms the first barrier to pathogens Digestive system is protected by a chitin-based barrier and lysozyme,
More information3/17/2014. The Lymphatic System. Lymphatic System Overview Lymphatic Vessels and Flow of Lymph Lymphoid Cells, Tissues, and Organs
The Lymphatic System Lymphatic System Overview Lymphatic Vessels and Flow of Lymph Lymphoid Cells, Tissues, and Organs Overview of the Lymphatic System Slide 2 Major Components of the Lymphatic System
More information