XANTHONES AND AN ANTHRAQUINONE FROM STEM BARK AND ROOTS OF CRATOXYLUM ARBORESCENS
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1 XANTHNES AND AN ANTHRAQUINNE FRM STEM BARK AND RTS F CRATXYLUM ARBRESCENS (Xanthon dan Antrakuinon daripada Kulit Batang dan Akar Cratoxylum arborescens) Samsiah Jusoh 1,2 *, Laily B. Din 2, Zuriati Zakaria 1 Rice and Industrial Crop Research Centre, Malaysian Agricultural Research and Development Institute (MARDI), Persiaran MARDI-UPM, 00 Serdang, Selangor, Malaysia 2 School of Sciences and Food Technology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 00 UKM Bangi, Selangor, Malaysia Malaysia Japan Institute of Technology, Universiti Teknologi Malaysia, 100 Kuala Lumpur, Malaysia *Corresponding author: samsiah@mardi.gov.my Received: 2 November 201; Accepted: 2 June 201 Abstract Phytochemical studies were conducted on the stem bark and roots of Cratoxylum arborescens that has been collected from Post Brooke, Gua Musang, Kelantan, Malaysia. Cratoxylum arborescens has orange latex like iodin. The orange latex from stem bark could be found because of existing xanthones compounds. Extraction of the stem bark using organic solvents followed by extensive purification using standard procedure of purification yielded three known xanthones, pruniflorone H (1), cochinchinone C (2) and macluraxanthone (). Employing the same procedure, an anthraquinone, vismiaquinone () was isolated from the roots of the plants. These four compounds were characterized by NMR spectral data using 1D and 2D-techniques and comparison with the literature data. The result of this studies suggested that xanthones are the main compounds of Cratoxylum. Keywords: cochinchinone C, guttiferae, macluraxanthone, prunifolorone H, vismiaquinone Abstrak Kajian fitokimia yang dijalankan ke atas kulit batang dan akar Cratoxylum arborescens yang telah dikumpul dari Post Brooke, Gua Musang, Kelantan, Malaysia. Cratoxylum arborescens mempunyai lateks berwarna jingga seperti iodin. Lateks jingga daripada kulit batang membuktikan kewujudan sebatian xanthon. Pengekstrakan kulit batang menggunakan pelarut organik diikuti dengan pemisahan ekstensif menggunakan kaedah pemencilan yang biasa menghasilkan tiga sebatian xanthon yang telah dikenal pasti, prunifloron H (1), cochinchinon C (2) dan makluraxanthon (). Menggunakan prosedur yang sama, antrakuinon, vismiakuinon () telah dipencilkan daripada akar pokok. Empat sebatian ini telah dikenal pasti menggunakan teknik RMN 1D dan 2D serta perbandingan dengan data literatur. Hasil kajian ini mencadangkan bahawa sebatian xanthon adalah sebatian utama Cratoxylum. Kata kunci: cochinchinon C, guttiferae, makluraxanthon, prunifoloron H, vismiakuinon Introduction Cratoxylum is a genus in the Guttiferae family. The genus is in same family to mangosteen. In Thailand, some species of this genus have been used for food poisoning and internal bleeding [1]. C. cochinchinense has been used for fever, cough, diarrhea and ulcers in folk medicine [2]. While C. formosum has been used for diarrhea, internal bleeding and food poisoning []. Besides that, Cratoxylum plant usually used as timber. Cratoxylum arborescens is known as Geronggang in Malaysia []. Usually, the height of this plant is more than 20 m height and could
2 Samsiah et al: XANTHNES AND AN ANTHRAQUINNE FRM STEM BARK AND RTS F CRATXYLUM ARBRESCENS achieved 1m in diameter without supporters. Local community at Gua musang reported the stem of this plant has yellow latex, and the latex is able to stop the bleeding from wound. This plant produce various types of secondary metabolites like xanthones [] and triterpenoids [,]. The leaves of this plant was previously reported to contain a flavonoid, astilbin []. Materials and Methods General Methods Ultraviolet spectra were measured using UV Spectrophotometer (Shimadzu). Infrared spectra (IR) were recorded with a Perkin Elmer Infrared Spectrometer. 1 H and 1 C Nuclear Magnetic Resonance (NMR) spectra were obtained using FT-NMR Bruker 00 MHz, whereas high resolution mass spectra were obtained using Gas Chromatography Mass Spectra Shimadzu QP00. Column chromatography (CC) was performed on silica gel (Merck). Pre-coated TLC sheets of silica gel 0F 2 were used small scale purification. Known compounds were identified by comparison of their spectroscopic data with those spectroscopic data reported in the literature. Plant Material The stem bark and roots of Cratoxylum arborescens were collected at Post Brooke, Gua Musang, Kelantan, Malaysia. The voucher specimen of C. arborescens (SK 192/11) was deposited at Herbarium UPM Serdang, Selangor, Malaysia. Extraction and Isolation The stem bark (9. g) and roots (.0 g) of C. arborescens were dried in oven at 0 o C, ground and extracted by using methanol as a solvent and the extraction was carried out at room temperature. The extraction of the stem bark powder was done for 2 hours by employing orbital shaker. The extraction was carried out for times, whilst the roots powder was soaked in methanol for five days at room temperature. The methanol extracts of the stem bark (11.1 g) and the roots (2.9 g) were fractionated with hexane and methanol (ratio 1:1). Fractionation of the stem bark extract yielded 2. g hexane fraction (GGCA) and. g methanol fraction (GGCC) while only 0. g fraction hexane of the roots extract (GGAA) and 1.2 g of methanol fraction (GGAC). The chemical components in hexane fraction of stem bark were separated by using column chromatography technique (CC). The mixture of chloroform, ethyl acetate and methanol as mobile phase yielded 2 fractions of ml eluent. Fractions - (0. mg) were combined and further purified by using preparative thin layer chromatography (PTLC) with chloroform as mobile phase and. mg yellowish crystal was obtained (). By employing PTLC on combined fractions using the same mobile phase yielded GGCA 2, a yellowish amorphous (11. mg). Fractions 1-11 were combined and further purified by using PTLC with a mixture of chloroform: ethyl acetate (9:1) as solvent yielded (. mg) as a yellowish amorphous. Initial purification of methanol fraction of roots by using vacuum liquid chromatography (VLC) with mobile phase of increasing polarity from 100% ethyl acetate until 100% methanol gave 1 fractions of 200 ml eluent. Fractions 1- were combined for further purification by using CC (internal diameter 1.0 cm x 0 cm height) with a mixture of ethyl acetate: methanol (:1) as an eluting solvent. The purification gave 21 fractions ( ml each fraction). Fractions - were combined for further purification using PTLC with hexane: ethyl acetate (9:1) as mobile phase. An orange crystal (. mg) was obtained and named as. The structure of the purified compound was analyzed using NMR, GCMS, UV and IR spectrometer. Pruniflorone H (1) Yellow crystal. UV max (MeH) :. (0.1), 290. (0.01), 21. (0.02), 2.0 (0.21), 21. (0.210) and 20. (0.21) nm. IR max (KBr) : (-H), 292, 2, 1, 100 and 1 cm -1. NMR 1 H (CDCl, 00 M :.0 (d, J=10.2 Hz, H-a),.21 (d, J=1. Hz, H-b),.99 (d, J=. Hz, H-),. (d, J=. Hz, H-),. (d, J=10.0 Hz, H-1 ),.9 (d, J=10.0 Hz, H-2 ), (m, H- a), (m, H- b), (m, H- ),.1 (br t, J=.2 Hz, H- ), 1.9 (s, H- ), 1. (s, H-9 ), 1.1 (s, H-10 ),.9 (dd, J=10., 1. Hz, H-2 ), 1. (s, H- ), 1. (s, H- ), 1.0 (s, 1-H),.0 (s, -H),.0 (s, - ). NMR 1 C (CDCl, 12 M : 1.
3 (C-1), 10.1 (C-2), 19. (C-), 11.0 (C-), 1. (C-a), 1. (C-b), 1. (C-), 11. (C-), 10. (C-), 11.9 (C-), 11.2 (C-a), 11.0 (C-9), (C-9a), 11. (C-1 ), 12. (C-2 ), 1.1 (C- ), 1. (C- ), 2. (C- ), 12. (C- ), 12.2 (C- ), 1. (C- ), 2.0 (C-9 ), 2. (C-10 ), 1. (C-1 ), 1. (C-2 ), 10. (C- ), 2. (C- ), 2. (C- ) and. (- ). Cochinchinone C (2) Yellow crystal. UV max (MeH) : (0.0) and 292 (1.0) nm. IR max (KBr) : 292, 1, 10.2, 100, 10, 121 and 00 cm -1. NMR 1 H (CDCl, 00 M :. (dd, J=0.9, 0.2 Hz, H-2),. (dt, J=.22, 1. Hz, H-),. (dd, J=0.9, 0.2 Hz, H-),. (s, H-), 2.0 (d, J=12. Hz, H-10a), 1.1 (d, J=1.Hz, H-10b), 2. (d, J= 9. Hz, H-11), 1.1 (s, H-1), 1. (s, H-1), 2. (d, J=.2Hz, H-1),.0 (br t, J=.0 Hz, H-1), 1. (d, J=2.Hz, H-1), 1.01 (s, H-19), 12.0 (d, J=1.Hz, 1-H),. (d, J=1.Hz, - ). NMR 1 C (CDCl, 12 M : 12. (C-1), 109. (C-2), 19.1 (C-), 10. (C-), 19. (C-a),. (C-b),.2 (C-), 201. (C- ),. (C-), 1.1 (C-), 12.1 (C-a), 10. (C-9), 10.1 (C-9a), 29. (C-10), 9. (C-11),.1 (C-12), 0. (C- 1), 29.1 (C-1), 29.2 (C-1), 11. (C-1), 1.9 (C-1), 2. (C-1), 1. (C-19) and.2 (- ). Macluraxanthone () Yellow crystal. UV max (MeH) : (0.01) dan 2 (1.1) nm. IR max (KBr) : 2, 2 (H), 1, 11, 110 and 1 cm -1. NMR 1 H (CDCl, 00 M : 1. (1-H),.9 (d, J=9.0 Hz, H-),.0 (d, J=9.0 Hz, H-),. (d, J=9. Hz, H-1 ),.9 (d, J=9. Hz, H-2 ),. (dd, J=10.2, 1. Hz, H-2 ),.2 (d, J=1. Hz, H-a ),.0 (d, J=10.2 Hz, H-b ), 1. (s, H, H-, H- ) and 1. (s, H, H-, H- ). RMN 1 C ((CD ) 2 C, 12 M : 1.0 (C1), 10. (C-2), 19.0 (C-), 112. (C-), 1.1 (C-a), 1. (C-b), 11.1 (C-), 19.0 (C-), 112. (C-), 11. (C-), 11. (C-a), 10. (C-9), 10.0 (C-9a), 11.1 (C-1 ), 12. (C-2 ),. (C- ), 2.9 (C-, C-, ), 1. (C-1 ), 1. (C-2 ), 10. (C- ) and 2.2 (C-, C-, ). Vismiaquinone () range crystal. UV max (MeH) : 29.0 (0.12), 2.0 (0.11) and 222. nm. IR max (KBr) : 2 (H), 292, 1 and 122 cm -1. NMR 1 H (CDCl, 00 M : 12.9 (s, 1-H), (s, -H),.2 (s, H-),. (s, H-),.0 (s, H-),. (dd, J=1.2, 1.2 Hz, H-1 ),.9 (dd, J=1.2,.2 Hz, H-2 ), 2. (s, H- ), 1.1 (d, J=.Hz, H- ), 1.1 (d, J=.Hz, H- ), 2. (sextet, - ) and.0 (s, - ). NMR 1 C (CDCl, 12 M : 12.1 (C- 1), (C-2), 1.0 (C-), 10. (C-), 12.1 (C-a), (C-), 1. (C-), 12. (C-), 12. (C-), 11. (C-a), 1.2 (C-b), 12.0 (C-9), 110. (C-9a), 191. (C-10), 11. (C-1 ), 1. (C-2 ),. (C- ), 22. (C- ), 22. (C- ), 22.2 (- ) and. (- ). Results and Discussion The structure of compounds were elucidated using spectroscopy methods i.e. IR, UV, MS and 1 H and 1 C NMR. The 1 H and 1 C NMR data of, and and GGCA 2 were presented in Table 1 and 2 respectively. Infrared spectrum of showed H (1-H) absorption peak appeared at cm -1. It is in agreement with NMR proton spectrum that showed one hydroxyl group at δ 1.0 (s) while another hydroxyl (- H) appeared at δ.0 (s). It also showed five singlet peaks of five methyl groups at δ 1., 1.1, 1. (2 ) and 1.9 ppm. ne methoxyl group could be observed at δ.0 ppm. Four olefinic protons were observed at δ (m, H- a),.2-1. (m, H- b) and (m, H- ). Whilst other aromatic protons peaks appeared between δ.1 and. ppm. The 1 C NMR spectrum showed 1 quarternery carbons, five CH, three CH 2, one and five. The quarternery carbons were observed at δ 1. (C-1), 10.0 (C-2), 19. (C-), (C-), 1. (C-a), 1. (C-b), 1. (C-), 11. (C-), 11.1 (C-a), 10.9 (C-9), (C-9a), 1.0 (C- ), 12.1 (C- ) and 1. (C-1 ). The CH carbons were observed at δ 10. (C-), 11. (C-), 11. (C-1 ), 12. (C-2 ) and (C- ). The CH 2 carbons were observed at δ 1. (C- ), 2.2 (C-) and 10. (C- ), carbon were observed at δ 1. (C- ), 2.9 (C-9 ), 2. (C-10 ), 2.2 (C- ), 2. (C- ) and the carbon was observed at δ.. The proton and carbon NMR data of were in agreement with pruniflorone H that has been isolated from Cratoxylum formosum ssp. pruniflorum reported by Boonnak et al. [9]. The 1 H NMR spectrum of GGCA 2 showed three singlet of three methyl groups at δ 1.0, 1. and 1.0 ppm, one methoxyl group at δ. (s) and a hydroxyl group that is forming a hydrogen bonding to carbonyl at δ (s). Three aromatic protons that are an ABM system were observed at δ. (dq, J=0.9, 0.2 Hz, H-2),. (dt,
4 Samsiah et al: XANTHNES AND AN ANTHRAQUINNE FRM STEM BARK AND RTS F CRATXYLUM ARBRESCENS J=.22, 1. Hz, H-) and. (dq, J=0.9, 0.2 Hz, H-). A coupling of a methylene group (H-10a and H-10b) was observed at δ 2.0 (d, J=12. and 1.1 (d, J=1. respectively, a methine proton of H-11 at δ 2. (d, J=9. and prenyl unit at δ 2. (d, J=.2Hz, H-1),.0 (br t, J=.0Hz, H-1), 1. (d, J=2.Hz, H-1) and 1.01 (s, H-19). This GGCA 2 showed 2 peaks of carbon in NMR 10 MHz. A conjugated and non conjugated carbonyl resonances were observed at δ 10. (C-9) and 201. (C-). Four methyl groups were observed in NMR proton at δ 0. (C-1), 29.1 (C-1), 2. (C-1) and 1. (C-19). Two CH 2 groups were observed at δ 29. (C-10) and 29.2 ppm (C-1). There are six peaks of CH which were observed at δ 109. (C-2), 19.1 (C-), 10. (C-), 1.1 (C-), 9. (C-11) and 11. (C-1). While peaks of nine quarternery carbons were observed at δ 12. (C-1), 19. (C-a),. (C-b),.2 (C-),. (C-), 12.1 (C-a), 10.1 (C-9a),.1 (C-12) and 1.9 (C-1). The spectral data of GGCA 2 were consistent with the spectral data of cochinchinone C that has been isolated from the roots of C. cochinchinensis [10]. The 1 H NMR spectrum of compound showed an ortho correlation between H- and H- with J value of 9.0Hz. Same correlation was observed between H-1 and H-2 with J=9. Hz. A doublet doublet indicated a correlation between H-2 and H-a (J=1. and between H-2 and H-b (J=10.2. The correlation between two protons that are attached to the same carbon (C-) was observed at δ.2 (d, J=1. Hz, H-a) and.0 (d, J=10.2 Hz, H-b). A singlet observed at δ 1. was assigned to 1-H, a singlet at δ 1. was assigned for H- and H- and a singlet at δ 1. was assigned for H- and H-. The 1 C NMR showed the present of four methyl groups, one CH 2 and 10 quarternery carbons. Two methyl groups of C- andc- were observed as a singlet at δ 2.9 and the two other methyl groups of C- and C- were also appeared as a singlet at δ 2.1. The CH 2 was observed at δ 10. (C- ), CH at δ 112. (C-), 11. (C-), 11.1 (C-1 ), 12. (C-2 ) and 1. (C-2 ) while the 10 quarternery carbons were observed at δ 1.00 (C-1), 10. (C-2), 19.0 (C-), 112. (C-), 1.1 (C-a), 1. (C-b), 11.1 (C-), 19.0 (C-), 11. (C-a), 10. (C-9) and 10.0 (C-9a). The NMR data of 1 H and 1 C were agreement with the data obtained from macluraxanthone, a compound that has been isolated by Laphookhieo et al., 2009 from the stem bark of C. maingayi. Macluraxanthone was reported to be very potent against cancer cell NCI-H1. This compound also exhibited a strong activity against P. falciparum (anti-malarial activity) [11, 12]. The 1 H NMR spectrum of compound showed five singlet at δ.2 (s, H-),. (s, H-),.0 (s, H-), (s, -H) and.0 (s, - ). These five singlet peaks are an indication of anthraquinone skeleton. Five other peaks were observed at δ. (dd, J=1.2, 1.2 Hz, H-1 ) and.9 (dd, J=1.2,.2 Hz, H-2 ), a sextet at δ 2. (sextet, H- ) and a doublet at δ 1.1 (d, J=. which represent H- and H-. Eleven quarternery carbon peaks and five CH peaks were observed in DEPT-C spectrum in region between 100 and 10 ppm i.e. C-, C-, C- C-1 and C-2.There is no CH 2 peak observed whilst the three methyl groups were observed at δ 22. (C-, C- ) and 22.2 (C- ). The 1 H and 1 C NMR data of were compared with the data of vismiaquinone, a compound that has been isolated from roots of C. formosum [1]. The CSY NMR spectrum confirmed that the structure of is vismiaquinone. It was based on the correlation between H-1 with H-2 and H- with H-. These correlation means that the four protons are adjacent to each other. H a b " 9 9a a " H 1 1" 2" CH 2 " 2 1' 2' ' 9' ' ' ' 10' ' ' 1 (1) (2) b a a 9a 1 H 2
5 H H 9 1 1' 2' H a 9a 2 ' b a ' ' H 9 1 1' ' ' CH a 9a 2 " 2' 1" H b a " 2" CH 10 CH 2 " () () ' Table 1. The 1 H and 1 C NMR data of, and Position of C / H (s, 1-H) (s, 1-H) (s, 1-H) a (d, J=10.2 b.21 (d, J= (s) a b (s) (s, -H) (d, J= (d, J= (s) 11.. (d, J= (d, J= a (s, -H) b a a (d, J= (d, J= (dd, J=1.2, (d, J= (d, J= (dd, J=1.2, (sextet) a (m) (s) (d, J=. b (m) (m) (s) (d, J= (br t,
6 Samsiah et al: XANTHNES AND AN ANTHRAQUINNE FRM STEM BARK AND RTS F CRATXYLUM ARBRESCENS Position of C / H Table 1 (cont d). The 1 H and 1 C NMR data of, and (s) (s) (s) (dd, J=1., (dd, J=1., 10.2 a (d, J=1. b.0 (d, J= (s) (s) (s) (s) (s) -..0 (s) -..0 (s) Table 2. The 1 H and 1 C NMR data of GGCA 2 Position of C / H GGCA 2 (ppm) H of GGCA (d, J=1. Hz, 1-H) (dq, J=0.9, 0.2 a (dt, J=.22, (dq, J=0.9, 0.2 a 19.1 b (s) a a a (d, J=12. 10b 1.1 (d, J= (d, J= (s) (s) (d, J= (br t, J= (d, J= (s) -.1. (d, J=1. 0
7 Conclusion In the previous phytochemical studies on the leaves plant, one flavonoid, astilbin has been isolated and identified. Studies on the hexane fraction of stem bark of C. arborescens, gave pruniflorone H, cochinchinone C and macluraxanthone were isolated while an anthraquinone, vismiaquinone was isolated from the methanol fraction of the roots extract. This is the new finding of these four compounds on C. arborescens according to the author knowledge and reading. Acknowledgement The authors would like to thank the Ministry of Agriculture and Agro-based Industry (MA), MARDI, Grant UKM-ST-0-FRGS and Grant UKM GUP for financial support. We also would like to thank Dr. Shamsul Khamis for identifying the plant material, Mr. Mohd. Zahid Md. Yusoff and Centre for Research and Instrumentation (CRIM, UKM) for NMR analysis. References 1. Grosvenor, P. W., Gothard, P. K., William, N. C., Supriono, A. AND Gray, D.. (199). Medicinal plants fro m Riau Province, Sumatra, Indonesia. Part 1: Uses. Journal of Ethnopharmacology, (2): Vo, V. V. (199). A dictionary of medicinal plants in Vietnam. Vol. Y Hoc Publisher, Ho Chi Minh City.. Anderson, E. F. (19). Ethnobotanic of hill tribes of Northen of Thailand. II. Lahu medicinal plants. Economic Botany, 0: Cratoxylum arborescens (Vahl) Blume, nationalherbarium (2009). [cited 2 ct 20 09].. Sia, G. L., Bennet, G. J., Harrison, L. J. and Sim, K. Y. (199). Minor xanthones from the bark of Cratoxylum cochinchinense. Phytochemistry, (): Nguyen, L. H. D. and Harrison, L. J. (199). Triterpenoid and xanthone constituents of Cratoxylum cochinchine nse. Phytochemistry, 0: 1.. Bennet, G. J., Harrison, L. J., Sia, G. L. and Sim, K. (199). Triterpenoids, tocotrienols and xanthones from the bark of Cratoxylum cochinchinense. Phytochemistry, 2 (): Samsiah, J., Zakaria, Z. & Din, L. B. (201). Isolation of astilbin from leaves of Cratoxylum arborescens. Mala ysian Journal of Analytical Sciences, 1(): Boonnak, N., Karalai, C., Chantrapromma, S., Ponglimanont, C., Fun, H. K., Kanjana-pas, A. & Laphookhieo, S. (200). Bioactive prenylated xanthones and anthraquinones from Cratoxylum formosum ssp. pruniflorum. T etrahedron, 2: Mahabusarakam, W., Nuangnaowarat, W. and Taylor, W. C. (200). Xanthone derivatives from Cratoxylum co chinchinense roots. Phytochemistry, (): Iinuma, M., Tosa, H., Tanaka, T. and Yonemori, S. (199). Two xanthones from root bark of Calophyllum inop hyllum. Phytochemistry, : Laphookhieo, S., Maneerat, W. and Koysomboon, S. (2009). Antimalarial and cytotoxic phenolic compounds fr om Cratoxylum maingayi and Cratoxylum cochinchinense. Molecules, 1: Boonsri, S., Karalai, C., Ponglimanont, C., Kanjana-pas, A. & Chantrapromma, K. (200). Antibacterial and cytotoxic xanthones from the roots of Cratoxylum formosum. Phytochemistry, :
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