Drug Discoveries & Therapeutics. 2013; 7(6):
|
|
- Rosalyn Lynch
- 5 years ago
- Views:
Transcription
1 Drug Discoveries & Therapeutics. 0; ():-. Brief Report DI: 0./ddt.0.v.. xoprothracarcin, a novel pyrrolo[,]benzodiazepine antibiotic from marine Streptomyces sp. M0 Yong an, Yaoyao Li, Yan Shen, Jie Li, Wenjun Li, Yuemao Shen, * Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji'nan, Shandong, China; Yunnan Institute of Microbiology, Yunnan University, Kunming, Yunnan, China. ABSTRACT: A novel pyrrolo[,]benzodiazepine antibiotic, designated oxoprothracarcin (), was isolated from the marine strain Streptomyces sp. M0 along with three known secondary metabolites, cyclo(d)-pro-(d)-val (), cyclo(d)-pro- (D)-Leu (), and limazepine A (). The chemical structures of these substances were elucidated by spectroscopic analyses, including D- and D-MR and ESI-MS. Antitumor and antibacterial assays indicated that compounds weakly inhibit the growth of MDA-MB- and A cells. The isolation of compound with a high yield ( mg/0 L) indicated that this marine S. sp. M0 may provide new lead compounds for structural modification and drug screening. Keywords: Marine Streptomyces, cyclo(d)-pro-(d)-val, cyclo(d)-pro-(d)-leu, oxoprothracarcin, limazepine A. Introduction Traditionally, secondary metabolites produced by microorganisms, and especially terrestrial actinomycetes, are remarkable sources of lead compounds for drug discovery (). owever, the rate at which new metabolites from terrestrial actinomycetes are discovered has decreased, and the rate of reisolation of known compounds has increased due to the replication of isolating microbial strains (). Compared to terrestrial actinomycetes, marine actinomycetes are relatively unexploited sources (). The fact that marine Streptomyces in particular are rich in novel bioactive metabolites is just becoming apparent (-). Moreover, genetic analysis has indicated that some marine-derived *Address correspondence to: Dr. Yuemao Shen, School of Pharmaceutical Sciences of Shandong University, o. West Wenhua Road, Ji'nan, Shandong 00, China. yshen@sdu.edu.cn Streptomyces form an independent clade (). The present study obtained four metabolites, i.e. cyclo(d)- Pro-(D)-Val () (), cyclo(d)-pro-(d)-leu () (), oxoprothracarcin () (-), and limazepine A () () (Figure ), from the metabolites of marine Streptomyces sp. M0. Reported here are the isolation, structural determination, and antitumor and antibacterial activities of compounds -.. Materials and Methods.. General MR spectra were recorded on a Bruker Advance 00 spectrometer (Bruker, Fällanden, Switzerland) at 00/0 Mz. Mass spectra were obtained on ABI-000 mass spectrometers (AB SCIEX, Framingham, MA, USA). An Agilent 0 PLC system (Agilent, Santa Clara, CA, USA) with a C- column (. 0 mm, μm) was also used. Column chromatography included a RP- (Merck, Darmstadt, Germany) column and a Sephadex L-0 column (GE healthcare, Uppsala, Sweden). TLC analyses were performed with precoated silica gel GF plates ( mm, Qingdao Marine Chemical Factory, Qingdao, China). All general chemical reagents were purchased from Sinopharm Chemical Reagent Company (Beijing, China). Figure. Chemical structures of compounds.
2 Drug Discoveries & Therapeutics. 0; ():-... Microorganism sample The strain Streptomyces sp. M0 was isolated from mangrove sediment collected from ut Bay and grown on medium containing trehalose as the sole carbon source [trehalose 0g, ( ) S. g, K P. g, K P. g, MgS.0 g, CuS 0.00 g, FeS 0.00 g, MnCl 0.00 g, ZnS 0.00 g, distilled water L, p.-.] at ºC. This strain was identified as Streptomyces sp. by partial S rra gene sequencing analysis... Tumor cell lines The MDA-MB- human breast cancer cell line and A human lung cancer cell line were purchased from the American Type Culture Collection (ATCC). All cells were maintained in DMEM with 0% fetal bovine serum (FBS, Gibco) in a humidified C incubator in % C at C... Fermentation and isolation Fermentation took place for d on YMG (0 L) agar plates at C. The culture was diced and extracted with AcEt/Me/Ac (0::). The organic solution was collected through filtration and the remaining agar residue was extracted exhaustively with the same solvent until the filtrate was colorless. Upon evaporation, the combined filtrate yielded a crude extract. The crude extract was partitioned between water and EtAc (:, v/v) until the EtAc layer was colorless. The EtAc extract was partitioned between Me and petroleum ether. The Me layer was concentrated in a vacuum to yield a brown syrupy extract (. g). The extract was subjected to MPLC (0 g RP- silica gel; 0%, 0%, 0%, and 00% Me, L for each gradient) to yield fractions, Fr. a d. Fraction a ( mg) was separated by column chromatography (CC) over Sephadex L-0 (in Me) to yield one subfraction (Fr.a.). Fr.a. ( mg) was subjected to PLC (C- column,. 0 mm, μm; 0% Me) to yield ( mg) and ( mg). Fraction b (0 mg) was subjected to CC over Sephadex L-0 (in Me) to yield two subfractions (Fr.b. and Fr.b.). Fr.b. (mg) was purified by Sephadex L-0 (in Me) to yield ( mg). Fr.b. ( mg) was purified by recrystallization (Me) to yield (0 mg)... Biological study The cytotoxicity of compounds - was assessed using a -(,-dimethylthiazol--yl),-diphenyltetrazolium bromide (MTT) cell survival assay (), Briefly, MDA-MB- and A cells were seeded in -well plates overnight and treated three times with increasing concentrations of compounds. After the cells were treated for h, a 0-μL of aliquot of MTT solution ( mg/ml) was added and cells were incubated for h at C. Two hundred μl of DMS was then added to dissolve formazan crystals. The color density was measured with a microplate reader (M-0, Bio- Rad) at 0 nm. Growth inhibition rates were calculated as follows: (A0 control cells A0 treated cells )/A0 control cells 00%. The antibacterial activity of compounds - was tested against Bacillus subtilis (CMCC (B) 0), Bacillus pumilus (CMCC (B) 0), and Penicillium avellaneum (UC ) using the filter paper method. Growth inhibition was calculated as the radius of the inhibition zone.. Results and Discussion. Elucidation of the structures of compounds ESI-MS revealed the molecular weight of compound to be Da. The C-MR spectrum of (Table ) displayed 0 signals. The -MR spectrum of (Table ) displayed signals. -MR signals at δ. (t,. z, ) and.0 (s, ) and C-MR signals at δc. and. revealed the presence of two acylamino groups, indicating that is a cyclic dipeptide. -MR signals at δ.-. (m, ),.0 (d, J =., ), and 0. (d, J =., ) and C-MR signals at δc.,., and. indicated the presence of an isopropyl group. The MBC correlation from C(0) to C(), along with the - CSY correlation between C() C (0) C (), indicated the presence of fragment A (Figure ), which was a valine residue. -MR signals at δ.-. (m, ),.-. (m, ),.0-.0 (m, ), and.-. (m, ) and C-MR signals at δ.,., Table. -MR and C-MR spectroscopic data for compounds and (MeD) 0 δ in ppm. J in z. Compound Compound Pro.-. (m, ).-. (m, ).0-.0 (m).-. (m).0 (m). (t, J =.).-. (m).0 (d, J =., ) 0. (d, J =., ).t.t.t 0.0d.s Val.d.d.q.q.s Pro.0-. (m, ).-. (m).-.0 (m).-.0 (m).-. (m). (t, J =.).-. (m).-. (m, ).0-. (m) 0. (d, J =., ) 0. (d, J =., ).t.t.t 0.d.s Leu.d.t.d.q.q.s
3 Drug Discoveries & Therapeutics. 0; ():-. 0 A 0 and. indicated the presence of three C groups. Furthermore, the MBC spectrum showed that C () was correlated with C(). In combination with the - CSY correlation between C () C() C(), these findings indicated the presence of fragment B (Figure ), which was a proline residue (Figure ). The spectral data for were consistent with those reported in the literature (). Thus, compound was determined to be cyclo(d)-pro-(d)-val. ESI-MS revealed the molecular weight of compound to be 0 Da. The chemical structure of was determined by comparing MR data for with those for. Both compounds had similar spectroscopic data (Table ), except for C(), C(), and C(). -MR signals at δ.-. (m, ),.0-. (m, ), 0. (d, J =., ), and 0. (d, J =., ) and C-MR signals at δc.,.,., and. indicated the presence of an isobutyl group. The MBC spectrum showed that C() was correlated with C(). Along with the - CSY correlation between C() C (0) C() C (), these findings indicated that had a leucine residue. The spectral data of were consistent with those reported in the literature (). Therefore, compound was determined to be cyclo(d)-pro-(d)-leu. ESI-MS data revealed the molecular weight of compound to be Da. The -MR spectrum of (Table ) displayed signals. The C-MR spectrum of (Table ) displayed signals for one methyl, two methylenes, six methines, and five quaternary carbon atoms, including two carbonyl groups (with one at δc. C() and the other at δc. C()). This suggested the presence of two acylamino groups as in compounds and. The -MR signal at δ.0 (, m) and C-MR signals at δc. and. suggested a trisubstituted Compound B Figure. Selected MBC ( C) and - CSY ( ) correlations, and the structures of fragments A and B of compound. Table. -MR and C-MR spectroscopic data for compounds and (DMS-d ) Position a a / a Me.-. (m).-. (m) δ in ppm. J in z. Compound Compound.0 (d, J =.). (d, J =.). (d, J =.). (t, J =.). (t, J =.). (d, J =.) 0. (s). (dd, J =.,.).-.0 (m). (d, J =., ) A.t.s.t.s.s.d.d.d.d.s.s.d.d.q.-. (m).-. (m). (s).0 (d, J =.). (d, J =.). (s, ). (dd, J = 0.,.). (q, J =., ).0 (t, J =., ). (s, ).0t.s.d.s 0.s.d 0.d 0.s.s.s.0s.d.t.q.q double bond. The - CSY correlation between C() C() C() C() indicated that had a disubstituted benzene. ext, the MBC correlation from C() to C() indicated the presence of fragment A (Figure ). The double bond was assigned at C() and C() in accordance with the MBC correlation (Figure ) of δ. C () with δc. C() and δ., δ. C () and that of δ.0, δ. C () with δc. C(). The MBC correlation from C(a) and C () to C(), in combination with the - CSY correlation between C () C(a), indicated the presence of fragment B (Figure ). Therefore, compound was determined a a B Compound Figure. Selected MBC ( C) and - CSY ( ) correlations, and the structures of fragments A and B of compound.
4 Drug Discoveries & Therapeutics. 0; ():-. to be (S,E)--ethylidene-,-dihydro--benzo[e] pyrrolo[,-a][,]diazepine-,(0,a)-dione, a new natural product that has been registered (CAS o.: 0-- ). After consulting the names of reported analogues (-), compound was designated oxoprothracarcin. ESI-MS data revealed the molecular weight of compound to be Da. The -MR and C-MR spectral data for (Table ) were similar to those for. The -MR spectrum of (Table ) displayed signals. The C-MR spectrum of (Table ) displayed signals for two methyls, two methylenes, four methines, and seven quaternary carbon atoms, including two carbonyl groups (with one at δc.0 C() and the other at δc. C()). The -MR signal at δ. (, s) and C-MR signals at δc. and. suggested a trisubstituted double bond like that in compound. owever, the MBC correlation from C (), C (), C(a), C (), and C () to C() and the - CSY correlation between C () C () and C () C(a) indicated a C=C bond between C() and C(). The - CSY correlation between C() C(), and the C-MR signals at δc 0. C() and. C() indicated the presence of a methoxyl group at C() and a hydroxyl group at C(). The spectral data for compound were identical to those of limazepine A reported in the literature ()... Biological study At a concentration of 0 μm, compounds - inhibited the growth of MDA-MB- cells at rates of.%,.%, 0.%, and.%, and they inhibited the growth of A cells at rates of.%,.%,.%, and 0.%. The antibacterial activity of compounds - was tested against Bacillus subtilis (CMCC (B) 0), Bacillus pumilus (CMCC (B) 0), and Penicillium avellaneum (UC ) using the filter paper method. Activity of each compound was tested twice at a concentration of.0 mg/ml with a loading volume of 0 μl. Results indicated that compounds - had no effect on the growth of the bacteria tested at 0 μg/disc... Conclusions and perspectives Genetic analysis indicated that some marine Streptomyces form an independent clade (), so marine Streptomyces was surmised to potentially be rich in novel secondary metabolites. The present study succeeded in isolating only one new compound, which suggests that fermentation medium screening and/or genetic manipulation are needed to encourage the production of secondary metabolites in marine Streptomyces. owever, compound was isolated with a high yield ( mg/0 L) and could be used as a lead compound for structural modifications. Acknowledgement This work was financially supported by the Program (the ational Basic Research Program of China, grant no. 00CB0). References. Zheng Y, Shen Y. Clavicorolides A and B, sesquiterpenoids from the fermentation products of edible fungus Clavicorona pyxidata. rg Lett. 00; :0-.. Fenical W, Jensen PR. Developing a new resource for drug discovery: marine actinomycete bacteria. ature Chem Bio. 00; :-.. Bull AT, Stach JEM. Marine actinobacteria: ew opportunities for natural product search and discovery. Trends Microbiol. 00; :-.. Williams DE, Dalisay DS, Patrick B, Matainaho T, Andrusiak K, Deshpande R, Myers CL, Piotrowski JS, Boone C, Yoshida M. Padanamides A and B, highly modified linear tetrapeptides produced in culture by a Streptomyces sp. isolated from a marine sediment. rg Lett. 0; :-.. Sun P, Maloney K, am SJ, aste M, Raju R, Aalbersberg W, Jensen PR, izet V, ensler ME, Fenical W. Fijimycins A-C, three antibacterial etamycin-class depsipeptides from a marine-derived Streptomyces sp. Bioorg Med Chem. 0; :-.. Matsuo Y, Kanoh K, Jang J, Adachi K, Matsuda S, Miki, Kato T, Shizuri Y. Streptobactin, a tricatecholtype siderophore from marine-derived Streptomyces sp. YM-. J at Prod. 0; :-.. Xu Y, e J, Tian XP, Li J, Yang LL, Xie Q, Tang SK, Chen YG, Zhang S, Li WJ. Streptomyces glycovorans sp. nov., Streptomyces xishensis sp. nov. and Streptomyces abyssalis sp. nov. isolated from marine sediments. Int J Syst Evol Microbiol. 0; :-.. Fdhila F, Vázquez V, Sánchez JL, Riguera R. dd- Diketopiperazines: Antibiotics active against Vibrio anguillarum isolated from marine bacteria associated with cultures of Pecten maximus. J at Prod. 00; :-0.. Shimizu K, Kawamoto I, Tomita F, Morimoto M, Fujimoto K. Prothracarcin, a novel antitumor antibiotic. J Antibiotics. ; :. 0. Arima K, Kosaka M, Tamura G, Imanaka, Sakai. Studies on tomaymycin, a new antibiotic. I. Isolation and properties of tomaymycin. J Antibiotics. ; :.. Kariyone K, Yazawa, Kohsaka M. The structure of tomaymycin and oxotomaymycin. Chem Pharm Bull. ; :-.. Fotso S, Zabriskie TM, Proteau PJ, Flatt PM, Santosa DA, Mahmud T. Limazepines A F, pyrrolo [, ] benzodiazepine antibiotics from an Indonesian Micrococcus sp. J at Prod. 00; :0-.. Mosmann T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods. ; :-. (Received March, 0; Revised December 0, 0; Accepted December, 0)
5 Drug Discoveries & Therapeutics. 0; ():-. Appendix Cyclo[Val-Pro] (). Colorless crystal. - and C-MR spectral data: see Table. ESI-MS: m/z =. ([M + ] + ) and m/z =.( [M + a] + ). Cyclo[Leu-Pro] (). Colorless crystal. - and C-MR spectral data: see Table. ESI-MS: m/z =. ([M + ] + ) and m/z =.( [M + a] + ). xoprothracarcin (-ethylidene-,-dihydro-- benzo[e]pyrrolo[,-a][,]diazepine-,(0,a)- dione, ). White crystal. - and C-MR spectral data: see Table. ESI-MS: m/z =. ([M + ] + ) and m/z =.( [M + a] + ). Limazepine A (). White crystal. - and C-MR spectral data: see Table. ESI-MS: m/z =. ([M + ] + ) and m/z =. ([M + a] + ).
SUPPLEMENTARY MATERIAL
SUPPLEMENTARY MATERIAL Chemical constituents from Agrimonia pilosa Ledeb. and their chemotaxonomic significance Wei-jie Liu, Xue-qian Hou, Hao Chen, Jing-yu Liang*, Jian-bo Sun** Department of Natural
More informationA New Epoxy-cadinane Sesquiterpene from the Marine Brown Alga Dictyopteris divaricata
Mar. Drugs 2009, 7, 600-604; doi:10.3390/md7040600 Article PEN ACCESS Marine Drugs ISSN 1660-3397 www.mdpi.com/journal/marinedrugs A New Epoxy-cadinane Sesquiterpene from the Marine Brown Alga Dictyopteris
More informationSupporting Information
Electronic Supplementary Material (ESI) for MedChemComm. This journal is The Royal Society of Chemistry 2015 Supporting Information Synthesis and Biological Evaluation of D- gluconhydroximo-1, 5-lactam
More informationA Single fluorescent probe for Dual-imaging Viscosity and H 2 O 2 in Mitochondria with Different Fluorescence Signals in Living Cells
Supporting Information for A Single fluorescent probe for Dual-imaging Viscosity and H 2 O 2 in Mitochondria with Different Fluorescence Signals in Living Cells Mingguang Ren, Beibei Deng, Kai Zhou, Xiuqi
More informationAcremostrictin, a Highly Oxygenated Metabolite from the marine-derived fungus Acremonium strictum. Elin Julianti, PhD. Sekolah Farmasi ITB
Acremostrictin, a ighly xygenated Metabolite from the marine-derived fungus Acremonium strictum Elin Julianti, PhD. Sekolah Farmasi ITB Introduction The oceans cover 70% of our planet s surface and as
More informationGuajavadimer A, a dimeric caryophyllene-derived meroterpenoid with a new carbon skeleton from the leaves of Psidium guajava.
Guajavadimer A, a dimeric caryophyllene-derived meroterpenoid with a new carbon skeleton from the leaves of Psidium guajava. Chuang-Jun Li, Jie Ma, Hua Sun, Dan Zhang, and Dong-Ming Zhang* State Key Laboratory
More informationph Switchable and Fluorescent Ratiometric Squarylium Indocyanine Dyes as Extremely Alkaline Sensors
ph Switchable and Fluorescent Ratiometric Squarylium Indocyanine Dyes as Extremely Alkaline Sensors Jie Li, Chendong Ji, Wantai Yang, Meizhen Yin* State Key Laboratory of Chemical Resource Engineering,
More informationElectronic Supporting Information for
Electronic Supplementary Material (ESI) for RSC Advances. This journal is The Royal Society of Chemistry 2015 Electronic Supporting Information for Rhodamine based Turn-On Fluorescent Probe for Pb(II)
More informationThiol-Activated gem-dithiols: A New Class of Controllable. Hydrogen Sulfide (H 2 S) Donors
Thiol-Activated gem-dithiols: A New Class of Controllable Hydrogen Sulfide (H 2 S) Donors Yu Zhao, Jianming Kang, Chung-Min Park, Powell E. Bagdon, Bo Peng, and Ming Xian * Department of Chemistry, Washington
More informationSolid Phase Peptide Synthesis (SPPS) and Solid Phase. Fragment Coupling (SPFC) Mediated by Isonitriles
Solid Phase Peptide Synthesis (SPPS) and Solid Phase Fragment Coupling (SPFC) Mediated by Isonitriles Ting Wang a and Samuel J. Danishefsky a,b,* alaboratory for Bioorganic Chemistry, Sloan- Kettering
More informationTWO NEW ELLAGIC ACID GLYCOSIDES FROM LEAVES OF DIPLOPANAX STACHYANTHUS
Journal of Asian Natural Products Research, December 2004, Vol. 6 (4), pp. 271 276 TWO NEW ELLAGIC ACID GLYCOSIDES FROM LEAVES OF DIPLOPANAX STACHYANTHUS XIAO-HONG YAN and YUE-WEI GUO* State Key Laboratory
More informationDevelopment of a near-infrared fluorescent probe for monitoring hydrazine in serum and living cells
Supporting Information for Development of a near-infrared fluorescent probe for monitoring hydrazine in serum and living cells Sasa Zhu, Weiying Lin,* Lin Yuan State Key Laboratory of Chemo/Biosensing
More informationChlorizidine, A Cytotoxic 5H-Pyrrolo[2,1-a]isoindol-5-one-Containing Alkaloid from a Marine Streptomyces sp.
Supporting Information Chlorizidine, A Cytotoxic 5-Pyrrolo[2,1-a]isoindol-5-one-Containing Alkaloid from a Marine Streptomyces sp. Xavier Alvarez-Mico, Paul R. Jensen, William Fenical, Chambers C. ughes*
More informationSupporting Information. Efficient copper-catalyzed Michael addition of acrylic derivatives with primary alcohols in the presence of base
Supporting Information Efficient copper-catalyzed Michael addition of acrylic derivatives with primary alcohols in the presence of base Feng Wang, a Haijun Yang, b Hua Fu, b,c * and Zhichao Pei a * a College
More informationNeuroprotective and Antioxidant Constituents from Curcuma zedoaria Rhizomes
Supporting Information Rec. Nat. Prod. 9:3 (2015) 349-355 Neuroprotective and Antioxidant Constituents from Curcuma zedoaria Rhizomes Omer Abdalla Ahmed Hamdi 1, Lo Jia Ye 2, Muhamad Noor Alfarizal Kamarudin
More informationEur. J. Org. Chem WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, 2009 ISSN X SUPPORTING INFORMATION
Eur. J. rg. Chem. 2009 WILEY-VC Verlag Gmb & Co. KGaA, 69451 Weinheim, 2009 ISS 1434 193X SUPPRTIG IFRMATI Title: ew GM1 Ganglioside Derivatives for Selective Single and Double Labelling of the atural
More informationElectronic Supplementary Information
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2015 Electronic Supplementary Information ovel pseudo[2]rotaxanes constructed by selfassembly of dibenzyl
More informationElectronic Supplementary Information
Electronic Supplementary Information A Novel and Facile Zn-mediated Intramolecular Five-membered Cyclization of β-tetraarylporphyrin Radicals from β-bromotetraarylporphyrins Dong-Mei Shen, Chao Liu, Qing-Yun
More informationCytotoxic sesquiterpene lactones from Eupatorium lindleyanum
Journal of Asian Natural Products Research, Vol. 9, No. 4, June 2007, 339 345 Cytotoxic sesquiterpene lactones from Eupatorium lindleyanum N.-Y. YANG, S.-H. QIAN, J.-A. DUAN, P. LI * and L.-J. TIAN{ Department
More informationTHE JOURNAL OF ANTIBIOTICS. Polyketomycin, a New Antibiotic from Streptomyces sp. MK277-AF1. II. Structure Determination
THE JOURNAL OF ANTIBIOTICS Polyketomycin, a New Antibiotic from Streptomyces sp. MK277-AF1 II. Structure Determination ISAO MOMOSE, WEI CHEN, HIKARU NAKAMURA, HIROSHI NAGANAWA, HIRONOBU IINUMA and TOMIO
More informationChukvelutins A-C, 16-norphragmalin limonoids with unprecedented skeletons from Chukrasia tabularis var. velutina
Chukvelutins A-C, 16-norphragmalin limonoids with unprecedented skeletons from Chukrasia tabularis var. velutina Jun Luo, Jun-Song Wang, Jian-Guang Luo, Xiao-Bing Wang, and Ling-Yi Kong* Department of
More informationC 21 Steroidal Glycosides from Acidic Hydrolysate of Cynanchum otophyllum
Zhao YB et al. Chinese Herbal Medicines, 2014, 6(4): 319-323 319 Available online at SciVarse ScienceDirect Chinese Herbal Medicines (CHM) ISSN 1674-6384 Journal homepage: www.tiprpress.com E-mail: chm@tiprpress.com
More informationCatalytic decarboxylative alkylation of β-keto acids with sulfonamides via the cleavage of carbon nitrogen and carbon carbon bonds
Catalytic decarboxylative alkylation of β-keto acids with sulfonamides via the cleavage of carbon nitrogen and carbon carbon bonds Cui-Feng Yang, Jian-Yong Wang and Shi-Kai Tian* Joint Laboratory of Green
More informationSix novel steroids from culture of basidiomycete Polyporus ellisii
Regular Article Nat. Prod. Bioprospect. 2012, 2, 240 244 DOI 10.1007/s13659-012-0058-4 Six novel steroids from culture of basidiomycete Polyporus ellisii Shuang WANG, a,b Ling ZHANG, a Liang-Yan LIU, a,b
More informationSupporting Information
Notes Bull. Korean Chem. Soc. 2013, Vol. 34, No. 1 1 http://dx.doi.org/10.5012/bkcs.2013.34.1.xxx Supporting Information Chemical Constituents of Ficus drupacea Leaves and their α-glucosidase Inhibitory
More informationResearch Article. Flavonoids and other compound isolated from leaves of Aconitum carmichaeli Debx. growing in Viet Nam
Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2015, 7(6):228-234 Research Article ISSN : 0975-7384 CDEN(USA) : JCPRC5 Flavonoids and other compound isolated from leaves
More informationDelineation of the Role of Glycosylation in the Cytotoxic Properties of Quercetin using Novel Assays in Living Vertebrates
Delineation of the Role of Glycosylation in the Cytotoxic Properties of Quercetin using Novel Assays in Living Vertebrates Si-Hwan Park,, Hyun Jung Kim,, Soon-Ho Yim, Ah-Ra Kim, Nisha Tyagi, Haihong Shen,
More information8. CHAPTER IV. ANTICANCER ACTIVITY OF BIOSYNTHESIZED SILVER NANOPARTICLES
8. CHAPTER IV. ANTICANCER ACTIVITY OF BIOSYNTHESIZED SILVER NANOPARTICLES 8.1. Introduction Nanobiotechnology, an emerging field of nanoscience, utilizes nanobased-systems for various biomedical applications.
More informationSupporting Information
Supporting Information A single design strategy for dual sensitive ph probe with a suitable range to map ph in living cells Kang-Kang Yu, Ji-Ting Hou, Kun Li, * Qian Yao, Jin Yang, Ming-Yu Wu, Yong-Mei
More informationA New Cadinane Sesquiterpene from the Marine Brown Alga Dictyopteris divaricata
Molecules 2009, 4, 2273-2277; doi:0.3390/molecules4062273 Article OPEN ACCESS molecules ISSN 420-3049 www.mdpi.com/journal/molecules A New Cadinane Sesquiterpene from the Marine Brown Alga Dictyopteris
More informationSupporting Information Nitric oxide releasing photoresponsive nanohybrids as excellent therapeutic agent for cervical cancer cell lines
upporting Information itric oxide releasing photoresponsive nanohybrids as excellent therapeutic agent for cervical cancer cell lines Priya udhesh a, Kaviyarasan Tamilarasan a, Palaniappan Arumugam a and
More informationSynthesis and antitumor evaluation in vitro of 5-bromo-N-phenyl substituted isatin derivatives
Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2014, 6(9):307-312 Research Article ISS : 0975-7384 CDE(USA) : JCPRC5 Synthesis and antitumor evaluation in vitro of 5-bromo--phenyl
More informationA pillar[2]arene[3]hydroquinone which can self-assemble to a molecular zipper in the solid state
A pillar[2]arene[3]hydroquinone which can self-assemble to a molecular zipper in the solid state Mingguang Pan, Min Xue* Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China Fax:
More informationAnemhupehins A C, Podocarpane Diterpenoids from Anemone hupehensis
Natural Products and Bioprospecting (208) 8:3 35 https://doi.org/0.007/s3659-07-046-6 OIGINAL ATICLE Anemhupehins A C, Podocarpane Diterpenoids from Anemone hupehensis Xing Yu Kai-Ting Duan Zhen-Xiong
More informationSupporting Information
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2015 Supporting Information Enzyme-activatable Probe with a Self-immolative Linker for Rapid and Sensitive
More informationRameshwar Prasad Pandit and Yong Rok Lee * School of Chemical Engineering, Yeungnam University, Gyeongsan , Korea
Electronic Supplementary Material (ESI) for rganic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2014 Novel ne-pot Synthesis of Diverse γ,δ-unsaturated β-ketoesters by Thermal
More informationSupporting Information for. Boronic Acid Functionalized Aza-Bodipy (azabdpba) based Fluorescence Optodes for the. analysis of Glucose in Whole Blood
Supporting Information for Boronic Acid Functionalized Aza-Bodipy (azabdpba) based Fluorescence Optodes for the analysis of Glucose in Whole Blood Yueling Liu, Jingwei Zhu, Yanmei Xu, Yu Qin*, Dechen Jiang*
More informationTWO NEW TRITERPENE SAPONINS FROM THE TUBERS OF STACHYS SIEBOLDII. Hyeon Kyung Cho, Chung Sub Kim, Won Se Suh, Ki Hyun Kim, and Kang Ro Lee*
ETERCYCLES, Vol. 89, No. 11, 2014 2619 ETERCYCLES, Vol. 89, No. 11, 2014, pp. 2619-2626. 2014 The Japan Institute of eterocyclic Chemistry Received, 9th ctober, 2014, Accepted, 28th ctober, 2014, Published
More informationTwelve new compounds from the basidiomycete Boreostereum vibrans
Regular Article Nat. Prod. Bioprospect. 2012, 2, 200 205 DOI 10.1007/s13659-012-0060-x Twelve new compounds from the basidiomycete Boreostereum vibrans Jian-Hai DING, a,b,c Tao FENG, a Zheng-Hui LI, a
More informationZinc Chloride Promoted Formal Oxidative Coupling of Aromatic Aldehydes and Isocyanides to α- Ketoamides
Supporting information for Zinc Chloride Promoted Formal xidative Coupling of Aromatic Aldehydes and Isocyanides to α- Ketoamides Marinus Bouma, Géraldine Masson* and Jieping Zhu* Institut de Chimie des
More informationBy: Jin-Bo Fang, Wei Jia, Wen-Yuan Gao, Zhi Yao, Jie Teng, Ai-Hua Zhao, and Hong-Quan Duan
Antitumor Constituents from Alternanthera philoxeroides By: Jin-Bo Fang, Wei Jia, Wen-Yuan Gao, Zhi Yao, Jie Teng, Ai-Hua Zhao, and Hong-Quan Duan Fang, J., Jia, W., Gao, W., Yao, Z., Teng, J., Zhao, A.,
More informationDesign, synthesis and evaluation of ph-dependent hydrolysable emetine analogs as treatment for prostate cancer.
Design, synthesis and evaluation of p-dependent hydrolysable emetine analogs as treatment for prostate cancer. Emmanuel S. Akinboye, 1 Marc D. Rosen, 2 Samuel R. Denmeade, 2 Bernard Kwabi-Addo 3 and ladapo
More informationChiral Squaramide Derivatives are Excellent Hydrogen Bond Donor Catalysts. Jeremiah P. Malerich, Koji Hagihara, and Viresh H.
Chiral Squaramide Derivatives are Excellent ydrogen Bond Donor Catalysts Jeremiah P. Malerich, Koji agihara, and Viresh. Rawal* Department of Chemistry, University of Chicago, Chicago, Illinois 60637 E-mail:
More informationFluorescent probes for detecting monoamine oxidase activity and cell imaging
Fluorescent probes for detecting monoamine oxidase activity and cell imaging Xuefeng Li, Huatang Zhang, Yusheng Xie, Yi Hu, Hongyan Sun *, Qing Zhu * Supporting Information Table of Contents 1. General
More informationSupporting Information
Supporting Information Wiley-VCH 2008 69451 Weinheim, Germany Supporting Information Enantioselective Cu-catalyzed 1,4-Addition of Various Grignard Reagents to Cyclohexenone using Taddol-derived Phosphine-Phosphite
More informationSupporting Information. A Two-In-One Fluorescent Sensor With Dual Channels to. Discriminate Zn 2+ and Cd 2+
Electronic Supplementary Material (ESI) for RS Advances Supporting Information A Two-In-One Fluorescent Sensor With Dual hannels to Discriminate Zn 2 and d 2 Li-Kun Zhang, a Guang-Fu Wu, a Ying Zhang,
More informationDevelopment of a Cell-penetrating Peptide that Exhibits Responsive. Changes in its Secondary Structure in the Cellular Environment
Development of a Cell-penetrating Peptide that Exhibits Responsive Changes in its Secondary Structure in the Cellular Environment iroko Yamashita, 1 Takuma Kato, 2 Makoto ba, 2 Takashi Misawa, 1 Takayuki
More informationElectronic Supplementary Information. Quinine/Selectfluor Combination Induced Asymmetric Semipinacol Rearrangement of
Electronic Supplementary Information Quinine/Selectfluor Combination Induced Asymmetric Semipinacol Rearrangement of Allylic Alcohols: An Effective and Enantioselective Approach to α Quaternary β Fluoro
More informationp-toluenesulfonic Acid-Mediated 1,3-Dipolar Cycloaddition of
Supporting Information for: p-toluenesulfonic Acid-Mediated 1,3-Dipolar Cycloaddition of Nitroolefins with NaN 3 for Synthesis of 4-Aryl-NH-1,2,3-triazoles Xue-Jing Quan, Zhi-Hui Ren, Yao-Yu Wang, and
More informationSupporting Information
Electronic Supplementary Material (ESI) for ChemComm. This journal is The Royal Society of Chemistry 2018 Supporting Information Facile Three-Step Synthesis and Photophysical Properties of [8]-, [9]-,
More informationSUPPLEMENTARY MATERIAL
SUPPLEMENTARY MATERIAL Artepillin C, is it a good marker for quality control of Brazilian Green Propolis? Cui-ping Zhang 1, Xiao-ge Shen 1, Jia-wei Chen 1, Xia-sen Jiang 1, Kai Wang 2, Fu-liang Hu 1 *
More informationA Rare Secoiridoid Dimer Derivative from Ligustri lucidi fructus
RIGINAL ARTICLE Rec. Nat. Prod. 9:3 (2015) 323-328 A Rare Secoiridoid Dimer Derivative from Ligustri lucidi fructus Liangliang Gao 1,2, Xiaoqian Liu 1,2, Chun Li 1,2, Zhimin Wang 1,2 and Tao Guo 1,2 1
More informationSupporting Information
Electronic Supplementary Material (ESI) for rganic Chemistry Frontiers. This journal is the Partner rganisations 2016 Supporting Information Fangyi Li, Changgui Zhao, and Jian Wang* Department of Pharmacology
More informationTWO NEW SESQUITERPENE GLUCOSIDES FROM GYMNASTER KORAIENSIS
ETERCYCLES, Vol. 78, No. 11, 2009 2827 ETERCYCLES, Vol. 78, No.11, 2009, pp. 2827-285. The Japan Institute of eterocyclic Chemistry Received, 9th June, 2009, Accepted, 0th July, 2009, Published online,
More informationSupporting Information. as the nitro source
Supporting Information Efficient ipso-nitration of arylboronic acids with iron nitrate as the nitro source Min Jiang, a,b Haijun Yang,* a,b Yong Li, a,b Zhiying Jia b and Hua Fu b a Beijing Key Laboratory
More informationSupporting Information. Copper-catalyzed cascade synthesis of benzimidazoquinazoline derivatives under mild condition
Supporting Information Copper-catalyzed cascade synthesis of benzimidazoquinazoline derivatives under mild condition Shan Xu, Juyou Lu and Hua Fu* Key Laboratory of Bioorganic Phosphorus Chemistry and
More informationA Photostable AIE Luminogen for Specific Mitochondrial
SUPPORTING INFORMATION A Photostable AIE Luminogen for Specific Mitochondrial Imaging and Tracking Chris Wai Tung Leung,,# Yuning Hong,,# Sijie Chen, Engui Zhao, Jacky Wing Yip Lam, and Ben Zhong Tang
More informationANTIMICROBIAL ACTIVITY OF NON EDIBLE SEEDS AGAINST IMPORTANT PATHOGENIC MICROORGANISMS PROJECT REFERENCE NO.: 38S _B_MSC_010
ANTIMICROBIAL ACTIVITY OF NON EDIBLE SEEDS AGAINST IMPORTANT PATHOGENIC MICROORGANISMS PROJECT REFERENCE NO.: 38S _B_MSC_010 COLLGE BRANCH GUIDE STUDENTS : UNIVERSITY OF MYSORE, MYSORE : DEPARTMENT OF
More informationAnti-Aging Activity Of Cucurbita moschata Ethanolic Extract Towards NIH3T3 Fibroblast Cells Induced By Doxorubicin
Indonesian Journal of Cancer Chemoprevention, 2016, 7(2): 49-53 ISSN: 2088 0197 Anti-Aging Activity Of Cucurbita moschata Ethanolic Extract Towards NIH3T3 Fibroblast Cells Induced By Doxorubicin Laeli
More informationAnalytical Method for 2, 4, 5-T (Targeted to Agricultural, Animal and Fishery Products)
Analytical Method for 2, 4, 5-T (Targeted to Agricultural, Animal and Fishery Products) The target compound to be determined is 2, 4, 5-T. 1. Instrument Liquid Chromatograph-tandem mass spectrometer (LC-MS/MS)
More informationElectronic Supplementary Information
Electronic Supplementary Material (ESI) for Chemical Communications. This journal is The Royal Society of Chemistry 2018 Electronic Supplementary Information A ratiometric fluorescence probe for peroxynitrite
More informationA Novel Synthesis of Arylpyrrolo[1,2-a]pyrazinone Derivatives
Molecules 2004, 9, 574-582 molecules ISS 1420-049 http://www.mdpi.org A ovel Synthesis of ylpyrrolo[1,2-a]pyrazinone Derivatives Fei Wang*, Jiawei Wang and Shoufang Zhang School of Pharmaceutical Engineering,
More informationSupporting information for. Synthesis of phenothiazines from cyclohexanones and. 2-aminobenzenethiols under transition-metal-free conditions
Supporting information for Synthesis of phenothiazines from cyclohexanones and 2-aminobenzenethiols under transition-metal-free conditions Yunfeng Liao, a Pengcheng Jiang, a Shanping Chen, a Fuhong Xiao,
More information2,6,9-Triazabicyclo[3.3.1]nonanes as overlooked. amino-modification products by acrolein
Supplementary Information 2,6,9-Triazabicyclo[3.3.1]nonanes as overlooked amino-modification products by acrolein Ayumi Tsutsui and Katsunori Tanaka* Biofunctional Synthetic Chemistry Laboratory, RIKEN
More informationSupporting information
Supporting information Rhabdopeptide/Xenortide-like Peptides from Xenorhabdus innexi with Terminal Amines Showing Potent Anti-protozoal Activity Lei Zhao,, Marcel Kaiser,, Helge B. Bode *,, Molekulare
More informationSupporting Information
Supporting Information Unconventional Passerini Reaction towards α-aminoxyamides Ajay L. Chandgude, Alexander Dömling* Department of Drug Design, University of Groningen, Antonius Deusinglaan 1, 9713 AV
More informationSupporting Information. Radical fluorination powered expedient synthesis of 3 fluorobicyclo[1.1.1]pentan 1 amine
Electronic Supplementary Material (ESI) for rganic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2015 Supporting Information Radical fluorination powered expedient synthesis
More informationNaoya Takahashi, Keiya Hirota and Yoshitaka Saga* Supplementary material
Supplementary material Facile transformation of the five-membered exocyclic E-ring in 13 2 -demethoxycarbonyl chlorophyll derivatives by molecular oxygen with titanium oxide in the dark Naoya Takahashi,
More informationSupporting Information. were prepared from commercially available ethyl acetoacetate by alkylation with the
ighly Stereoselective Reductions of α-alkyl-1,3-diketones and α- Alkyl-β-keto esters Catalyzed by Isolated NADP-dependent Ketoreductases Dimitris Kalaitzakis, a David J. Rozzell b, Spiros Kambourakis *b
More informationNational Defense Academy, Hashirimizu, Yokosuka, , Japan
Suppoing Information for Reaction of Arynes with Amino Acid Esters Kentaro kuma, a * ahoko Matsunaga, a oriyoshi agahora, a Kosei Shioji, a and Yoshinobu Yokomori b a Depament of Chemistry, Faculty of
More informationSupporting Materials. Experimental Section. internal standard TMS (0 ppm). The peak patterns are indicated as follows: s, singlet; d,
CuBr-Catalyzed Efficient Alkynylation of sp 3 C-H Bonds Adjacent to a itrogen Atom Zhiping Li and Chao-Jun Li* Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, Quebec H3A
More informationAsymmetric organocatalytic diboration of alkenes
Asymmetric organocatalytic diboration of alkenes Amadeu Bonet, a Cristina Solé, Henrik Gulyás,* Elena Fernández* a Dept. Química Física i Inorgànica, University Rovira i Virgili, C/Marcel lí Domingo s/n,
More informationAn Orthogonal Array Optimization of Lipid-like Nanoparticles for. mrna Delivery in Vivo
Supporting Information An rthogonal Array ptimization of Lipid-like Nanoparticles for mrna Delivery in Vivo Bin Li, Xiao Luo, Binbin Deng, Junfeng Wang, David W. McComb, Yimin Shi, Karin M.L. Gaensler,
More informationVOL. 56 NO. 2, FEB THE JOURNAL OF ANTIBIOTICS pp YM and YM , Novel Thiopeptide Antibiotics Produced
VOL. 56 NO. 2, FEB. 2003 THE JOURNAL OF ANTIBIOTICS pp. 129-134 YM-266183 and YM-266184, Novel Thiopeptide Antibiotics Produced by Bacillus cereus Isolated from a Marine Sponge II. Structure Elucidation
More informationSynthesis and Blastocyst Implantation Inhibition Potential of Lupeol Derivatives in Female Mice
Supporting Information Rec. Nat. Prod. 9:4 (2015) 561-566 Synthesis and Blastocyst Implantation Inhibition Potential of Lupeol Derivatives in Female Mice Anita Mahapatra 1*, Purvi Shah 1, Mehul Jivrajani
More informationSynthetic chemistry-led creation of a difluorinated biaryl ether non-nucleoside reverse transcriptase inhibitor
upplementary Material for rganic & Biomolecular Chemistry ynthetic chemistry-led creation of a difluorinated biaryl ether non-nucleoside reverse transcriptase inhibitor Lyn. Jones* Amy Randall, scar Barba
More informationNovel D-erythro N-Octanoyl Sphingosine Analogs As Chemo- and Endocrine. Resistant Breast Cancer Therapeutics
Page 11 of 32 Cancer Chemotherapy and Pharmacology Novel D-erythro N-Octanoyl Sphingosine Analogs As Chemo- and Endocrine Resistant Breast Cancer Therapeutics James W. Antoon, Jiawang Liu, Adharsh P. Ponnapakkam,
More informationSupporting Information
Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2014 Supporting Information 1. General Information...S2 a. Materials b. HPLC
More informationMasatoshi Shibuya,Takahisa Sato, Masaki Tomizawa, and Yoshiharu Iwabuchi* Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences,
Oxoammonium ion/naclo 2 : An Expedient, Catalytic System for One-pot Oxidation of Primary Alcohols to Carboxylic Acid with Broad Substrate Applicability Masatoshi Shibuya,Takahisa Sato, Masaki Tomizawa,
More informationSupplementary Material
10.1071/C15460_AC CSIR 2016 Australian Journal of Chemistry 69 (3), 328-335 Supplementary Material Synthesis and Characterization of Bradykinin Derivatives Based on a β-cyclodextrin Core Rachel J. Stephenson,
More informationManganese powder promoted highly efficient and selective synthesis of fullerene mono- and biscycloadducts at room temperature
Supplementary Information Manganese powder promoted highly efficient and selective synthesis of fullerene mono- and biscycloadducts at room temperature Weili Si 1, Xuan Zhang 1, Shirong Lu 1, Takeshi Yasuda
More informationFacile Cu(II) mediated conjugation of thioesters and thioacids to peptides and proteins under mild conditions
Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry. This journal is The Royal Society of Chemistry 2018 Facile Cu(II) mediated conjugation of thioesters and thioacids to peptides
More informationAcaulins A and B, Trimeric Macrodiolides from Acaulium. Table of Contents
Supporting Information Acaulins A and B, Trimeric Macrodiolides from Acaulium sp. H-JQSF Ting Ting Wang, Ying Jie Wei, Hui Ming Ge, Rui Hua Jiao, Ren Xiang Tan* * Corresponding author. E-mail: rxtan@nju.edu.cn
More informationSupporting Information. First synthetic entry to the trimer stage of 5,6-dihydroxyindole polymerization: orthoalkynylaniline-based
Supporting Information First synthetic entry to the trimer stage of 5,6-dihydroxyindole polymerization: orthoalkynylaniline-based access to the missing 2,7 :2,7 -triindole Luigia Capelli, Paola Manini,*
More informationA novel quinoline-based two-photon fluorescent probe for detecting Cd 2+ in vitro and in vivo
Supporting Information A novel quinoline-based two-photon fluorescent probe for detecting Cd 2+ in vitro and in vivo Yiming Li, a,b Hanbao Chong, a Xiangming Meng,* a Shuxin Wang, a Manzhou Zhu a and Qingxiang
More informationNOTE A NEW PHENOLIC COMPOUND FROM ACETONE EXTRACT OF LICHEN Usnea flexuosa Tayl.
290 NTE A NEW PHENLIC CMPUND FRM ACETNE EXTRACT F LICHEN Usnea flexuosa Tayl. Maulidiyah 1,*, A. Herry Cahyana 2, and Wahyudi Priyono Suwarso 2 1 Department of Chemistry, Faculty of Mathematics and Science,
More informationPhytochemistry 70 (2009) Contents lists available at ScienceDirect. Phytochemistry. journal homepage:
Phytochemistry 70 (2009) 773 778 Contents lists available at ScienceDirect Phytochemistry journal homepage: www.elsevier.com/locate/phytochem Dimeric 1,4-benzoquinone derivatives and a resorcinol derivative
More informationInhibitory Activities of Angiopteroside for HIV-1 Reverse Transcriptase and Lung Cancer Cell-line
Inhibitory Activities of Angiopteroside for HIV-1 Reverse Transcriptase and Lung Cancer Cell-line Somjintana Taveepanich 1, anthita Kamthong 2, arumon Sawasdipuksa 1 and Sophon Roengsumran 1* The structure
More informationSupporting Information. Recyclable hypervalent-iodine-mediated solid-phase peptide
Supporting Information Recyclable hypervalent-iodine-mediated solid-phase peptide synthesis and cyclic peptide synthesis Dan Liu, Ya-Li Guo, Jin Qu and Chi Zhang* for Address: State Key Laboratory of Elemento-Organic
More informationStudy of structure-bioactivity relationship of three new pyridine Schiff bases:
Electronic Supplementary Material (ESI) for New Journal of Chemistry. This journal is The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2018 Study of structure-bioactivity
More informationPreparation of Fluorinated Tetrahydropyrans and Piperidines using a New Nucleophilic Fluorination Reagent DMPU/HF
Supporting information Preparation of Fluorinated Tetrahydropyrans and Piperidines using a New Nucleophilic Fluorination Reagent DMPU/HF Otome E. Okoromoba, a Gerald B. Hammond, a, * Bo Xu b, * a Department
More informationSupporting Information. Palladium-catalyzed reductive cleavage of tosylated arene using isopropanol as the mild reducing agent
Electronic Supplementary Material (ESI) for Organic Chemistry Frontiers. This journal is the Partner Organisations 2014 Supporting Information Supporting Information Palladium-catalyzed reductive cleavage
More informationSUPPORTING INFORMATION TO: Oligonucleotide cyclization: The thiol-maleimide reaction revisited. Albert Sánchez, Enrique Pedroso, Anna Grandas*
SUPPRTIG IFRMATI T: ligonucleotide cyclization: The thiol-maleimide reaction revisited. Albert Sánchez, Enrique Pedroso, Anna Grandas* 1. General materials and methods, and abbreviations. 2. Solid phase
More informationSupporting Information
Supporting Information Developing Activity Localization Fluorescence Peptide Probe Using Thiol-Ene Click Reaction for Spatially Resolved Imaging of Caspase-8 in Live Cells Wei Liu,, Si-Jia Liu,, Yong-Qing
More informationSchwartz s reagent-mediated regiospecific synthesis of 2,3-disubstituted indoles from isatins
Electronic Supplementary Information (ESI) Schwartz s reagent-mediated regiospecific synthesis of 2,3-disubstituted indoles from isatins A. Ulikowski and B. Furman* Institute of Organic Chemistry, Polish
More informationNeglschisandrins C-D: Two New Dibenzocyclooctadiene Lignans from Schisandra neglecta
Molecules 2008, 13, 1148-1155; DI: 10.3390/molecules13051148 PEN ACCESS molecules ISSN 1420-3049 www.mdpi.org/molecules Article Neglschisandrins C-D: Two New Dibenzocyclooctadiene Lignans from Schisandra
More informationSupporting Information. for. Synthesis of 2,1-benzisoxazole-3(1H)-ones by basemediated. photochemical N O bond-forming
Supporting Information for Synthesis of 2,1-benzisoxazole-3(1H)-ones by basemediated photochemical N O bond-forming cyclization of 2-azidobenzoic acids Daria Yu. Dzhons and Andrei V. Budruev* Address:
More informationA New Alkaloid from Isatis costata
Turk J hem 31 (2007), 443 447. c TÜBİTAK A New Alkaloid from Isatis costata Itrat FATIMA 1,ItratANIS 1,IjazAMAD 2, Abdul MALIK 1,NighatAFZA 3 1 International enter for hemıcal Sciences, ej Research Institute
More informationSupporting Information. for. Access to pyrrolo-pyridines by gold-catalyzed. hydroarylation of pyrroles tethered to terminal alkynes
Supporting Information for Access to pyrrolo-pyridines by gold-catalyzed hydroarylation of pyrroles tethered to terminal alkynes Elena Borsini 1, Gianluigi Broggini* 1, Andrea Fasana 1, Chiara Baldassarri
More informationSupporting Information
Supporting Information B(C 6 F 5 ) 3 -catalyzed Regioselective Deuteration of Electronrich Aromatic and Heteroaromatic compounds Wu Li, Ming-Ming Wang, Yuya Hu and Thomas Werner* Leibniz-Institute of Catalysis
More information