Accuracy of the serum intestinal fatty-acid-binding protein for diagnosis of acute intestinal ischemia: a meta-analysis

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1 Supplementary table and figure legends Supplementary tables Table S1 Summary of study quality assessment Table S2 Summary of overall analysis and sensitivity analysis Supplementary figures Figure S1 Forest plots of PLR and NLR Figure S2 Forest plots of DOR Figure S3 Meta regression Figure S4 Deek s funnel plot showed no significant publication bias Figure S5 Fagan plot presents the clinical utility of I-FABP

2 Table S1. Summary of quality assessment of studies Author Year Was the Were Was the Were the Is the Were the Is the time Did the whole Did Was the Was the Were the same Were Were Score spectrum of select execution of index test period between sample or a patients execution clinical data uninter withdr patients ion the index results random receive of the available when pretabl awals representati crite test interpreted likely to results and selection of the same independ test results were e/ from ve of the ria described without correctly interpreted index test short the sample, ent of the interpreted as interm the patients clear in sufficient knowledge classify without enough to be receive index test described would be ediate study who will ly detail to of the the target knowledge reasonably verification regardles in available test explain receive the descr permit results of condition of the sure that the using a s of the sufficient when the test is results ed? test in ibed? replication the? results of target condition index test detail to used in reporte practice? of the test? the index did not change of result? permit its practice? d?? test? between the two diagnosis? replicatio tests? n? Shi H Yes Yes Yes Yes Yes Yes Yes No No Yes Yes Yes Yes Yes 12 Matsu moto S Yes Yes Yes Yes Yes Yes Yes No No Yes Yes Yes Yes Yes 12 Kittaka H Yes Yes Yes Yes Unclear Yes Yes Yes Yes Yes Yes Yes Yes Yes 13 Jin H Yes Yes Unclear Unclear Yes Unclear Yes No No Yes Yes Yes Yes Yes 9 Verme ulen Windsa nt IC Yes Yes Yes Yes Yes Unclear Yes Yes No Yes Yes Yes Yes Yes 12 Shi H Yes Yes Yes Yes Yes Unclear Yes No No Yes Yes Yes Yes Yes 11 Kanda 2011 Yes Yes Yes Yes Yes Yes Yes Yes No Yes Yes Yes Yes Yes 13

3 T 12 Thuijls G Yes Yes Yes Yes Unclear Yes Yes No No Yes Yes Yes Yes Yes 11 Cronk DR Yes Yes Yes Yes Yes Unclear Yes Yes No Yes Yes Yes Yes Yes 12 Total QUADAS score is out of 14. If the answer was yes to ten or more of the criteria listed for high quality, if the answer was yes to less than ten of the criteria listed for lower quality.

4 Table S2 Summary of overall analysis and sensitivity analysis Variables Number of Sensitivity Specificity DOR PLR NLR studies (95% CI) (95% CI) (95% CI) (95% CI) (95% CI) AUC Overall analysis ( ) 0.85( ) 24(9 65) 5.5( ) 0.23( ) 0.86( ) Researches carried out after ( ) 0.86( ) 25(8 75) 5.7( ) 0.23( ) 0.86( ) Studies used ELISA to detect I-FABP ( ) 0.82( ) 17(7 40) 4.3( ) 0.26( ) 0.84( ) DOR: diagnostic odds ratio; PLR: positive likelihood ratio; NLR negative likelihood ratio; AUC: area under curve; ELISA: enzyme-linked immunosorbent assays.

5 Figure S1. Forest plots of PLR and NLR

6 Figure S2. Forest plots of DOR

7 Figure S3. Meta regression

8 Figure S4. Deek s funnel plot showed no significant publication bias

9 Figure S5. Fagan plot presents the clinical utility of I-FABP