SCOPE OF ACCREDITATION TO ISO 15189:2012. PREVENTION GENETICS 3800 S. Business Park Ave. Marshfield, WI Jessica Kayhart Phone:

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1 SCOPE OF ACCREDITATION TO ISO 15189:2012 PREVENTION GENETICS 3800 S. Business Park Ave. Marshfield, WI Jessica Kayhart Phone: CLINICAL Valid To: September 30, 2018 Certificate Number: In recognition of the successful completion of the A2LA evaluation process, accreditation is granted to this laboratory to perform the following types of testing on human samples, including: Blood (B), DNA (D), Cell Cultures (C), Tissue (T), Saliva (Sa), and Semen (Se). Specialty Sub Specialty Test/Analyte Method Matrix Pathology Molecular Pathology Whole genome CMA acgh B, D, T, C, Sa Gene-centric acgh acgh B, D, T, C, Sa Prader- Willi/Angelman MLPA B, D, T, C Syndrome ABCA12 Gene Sanger sequencing, Se ABCA4 Gene, Sanger sequencing, Se ABCB4 Gene ABCB11 Gene Sanger sequencing, Se ABCC2 Gene Sanger sequencing, Se ABCC8 Gene ABCC9 Gene ABCD1 Gene Sanger sequencing, Se ABCD3 Gene, Se ABCD4 Gene Sanger sequencing, Se ACADM Gene Sanger sequencing, Se ACADS Gene Sanger sequencing, Se ACADVL Gene Sanger sequencing, Se ACE Gene Sanger sequencing, Se ACO2 Gene ACOX1 Gene ACP5 Gene Sanger sequencing, Se ACSF3 Gene Sanger sequencing, Se ACTA1 Gene Sanger sequencing, Se ACTA2 Gene Sanger sequencing, Se (A2LA Cert. No ) Revised 06/28/2018 Page 1 of 38

2 ACTC1 Gene Sanger sequencing, Se ACTN2 Gene Sanger sequencing, Se ACTN4 Gene Sanger sequencing, Se ACVR1 Gene Sanger sequencing, Se ACVR2B Gene Sanger sequencing, Se ACVRL1 Gene Sanger sequencing, Se ACY1 Gene ADA Gene Sanger sequencing, Se ADAM9 Gene ADAMTS13 Gene Sanger sequencing, Se ADAMTSL4 Gene Sanger sequencing, Se ADCK4 Gene Sanger sequencing, Se ADGRV1 Gene ADSL Gene Sanger sequencing, Se AFF4 Gene Sanger sequencing, Se AGA Gene Sanger sequencing, Se AGK Gene Sanger sequencing, Se AGL Gene AGPAT2 Gene Sanger sequencing, Se AGPS Gene Sanger sequencing, Se AGRN Gene AGT Gene Sanger sequencing, Se AGTR1 Gene Sanger sequencing, Se AGXT Gene Sanger sequencing, Se AHI1 Gene AICDA Gene Sanger sequencing, Se AIP Gene Sanger sequencing, Se AIPL1 Gene Sanger sequencing, Se AIRE Gene Sanger sequencing, Se AKAP9 Gene AKR1D1 Gene ALAS2 Gene Sanger sequencing, Se ALDH18A1 Gene Sanger sequencing, Se ALDH3A2 Gene Sanger sequencing, Se ALDH7A1 Gene ALDOB Gene Sanger sequencing, Se ALG12 Gene Sanger sequencing, Se ALG2 Gene Sanger sequencing, Se ALG3 Gene Sanger sequencing, Se ALG6 Gene Sanger sequencing, Se ALG8 Gene Sanger sequencing, Se ALK Gene Sanger sequencing, Se ALMS1 Gene Sanger sequencing, Se ALOX12B Gene Sanger sequencing, Se ALOXE3 Gene Sanger sequencing, Se ALPL Gene Sanger sequencing, Se ALS2 Gene Sanger sequencing, Se (A2LA Cert. No ) Revised 06/28/2018 Page 2 of 38

3 ALX3 Gene Sanger sequencing, Se AMELX Gene Sanger sequencing, Se AMT Gene Sanger sequencing, Se ANG Gene Sanger sequencing, Se ANK1 Gene ANK2 Gene ANKRD26 Gene ANKS6 Gene Sanger sequencing, Se ANLN Gene Sanger sequencing, Se ANO10 Gene Sanger sequencing, Se ANO5 Gene Sanger sequencing, Se ANO6 Gene ANOS1 Gene Sanger sequencing, Se ANTXR1 Gene Sanger sequencing, Se ANTXR2 Gene Sanger sequencing, Se AP2S1 Gene Sanger sequencing, Se AP3B1 Gene Sanger sequencing, Se APC Gene APOA1 Gene Sanger sequencing, Se APOB Gene Sanger sequencing, Se APP Gene Sanger sequencing, Se APTX Gene Sanger sequencing, Se AQP2 Gene Sanger sequencing, Se AR Gene Sanger sequencing, Se ARFGEF2 Gene ARHGEF9 Gene ARG1 Gene Sanger sequencing, Se ARL13B Gene Sanger sequencing, Se ARL6 Gene Sanger sequencing, Se ARMC5 Gene Sanger sequencing, Se ARSA Gene Sanger sequencing, Se ARSB Gene Sanger sequencing, Se ARSE Gene Sanger sequencing, Se ARX Gene Sanger sequencing, Se ASAH1 Gene Sanger sequencing, Se ASCL1 Gene Sanger sequencing, Se ASL Gene Sanger sequencing, Se ASPA Gene Sanger sequencing, Se ASPM Gene Sanger sequencing, Se ASS1 Gene Sanger sequencing, Se ATM Gene ATP1A2 Gene Sanger sequencing, Se ATP6V0A2 Gene Sanger sequencing, Se ATP6V0A4 Gene Sanger sequencing, Se ATP6V1B1 Gene Sanger sequencing, Se ATP7A Gene Sanger sequencing, Se ATP7B Gene Sanger sequencing, Se (A2LA Cert. No ) Revised 06/28/2018 Page 3 of 38

4 ATP8B1 Gene ATP13A2 Gene Sanger sequencing, Se ATR Gene Sanger sequencing, Se ATRX Gene Sanger sequencing, Se AUH Gene Sanger sequencing, Se AURKC Gene Sanger sequencing, Se AVP Gene Sanger sequencing, Se AVPR2 Gene Sanger sequencing, Se AXIN2 Gene Sanger sequencing, Se B3GALNT2 Gene Sanger sequencing, Se B3GLCT Gene Sanger sequencing, Se B4GAT1 Gene Sanger sequencing, Se B9D1 Gene Sanger sequencing, Se BAG3 Gene Sanger sequencing, Se BAP1 Gene Sanger sequencing, Se BARD1 Gene Sanger sequencing, Se BBS1 Gene Sanger sequencing, Se BBS10 Gene Sanger sequencing, Se BBS12 Gene Sanger sequencing, Se BBS2 Gene Sanger sequencing, Se BBS4 Gene Sanger sequencing, Se BBS5 Gene Sanger sequencing, Se BBS7 Gene Sanger sequencing, Se BBS9 Gene Sanger sequencing, Se BCHE Gene Sanger sequencing, Se BCKDHA Gene Sanger sequencing, Se BCKDHB Gene Sanger sequencing, Se BCKDK Gene BCOR Gene Sanger sequencing, Se BCS1L Gene Sanger sequencing, Se BDNF Gene Sanger sequencing, Se BEST1 Gene Sanger sequencing, Se BFSP1 Gene Sanger sequencing, Se BIN1 Gene Sanger sequencing, Se BLK Gene Sanger sequencing, Se BLM Gene BLOC1S3 Gene Sanger sequencing, Se BLOC1S6 Gene Sanger sequencing, Se BMP1 Gene Sanger sequencing, Se BMP15 Gene Sanger sequencing, Se BMP2 Gene Sanger sequencing, Se BMPR1A Gene Sanger sequencing, Se BMPR2 Gene Sanger sequencing, Se BRAF Gene Sanger sequencing, Se BRCA1 Gene Sanger sequencing,, Se (A2LA Cert. No ) Revised 06/28/2018 Page 4 of 38

5 BRCA2 Gene Sanger sequencing,, Se BRIP1 Gene Sanger sequencing, Se BSCL2 Gene Sanger sequencing, Se BSND Gene Sanger sequencing, Se BTD Gene Sanger sequencing, Se BTK Gene Sanger sequencing, Se BUB1B Gene C10orf2 Gene Sanger sequencing, Se C10orf11 Gene Sanger sequencing, Se C12orf65 Gene C15orf41 Gene Sanger sequencing, Se C4orf26 Gene Sanger sequencing, Se C5orf42 Gene C8orf37 Gene C9orf72 Gene Sanger sequencing, Se CA2 Gene Sanger sequencing, Se CA4 Gene Sanger sequencing, Se CABP4 Gene CACNA1A Gene CACNA1C Gene CACNA1F Gene Sanger sequencing, Se CACNA1S Gene Sanger sequencing, Se CACNA2D1 Gene CACNA2D4 Gene CACNB2 Gene Sanger sequencing, Se CALM2 Gene CAPN3 Gene Sanger sequencing, Se CASQ2 Gene Sanger sequencing, Se CASR Gene Sanger sequencing,, Se CAV3 Gene Sanger sequencing, Se CBL Gene Sanger sequencing, Se CBS Gene Sanger sequencing, Se CC2D2A Gene CCBE1 Gene Sanger sequencing, Se CCDC103 Gene Sanger sequencing, Se CCDC114 Gene Sanger sequencing, Se CCDC39 Gene Sanger sequencing, Se CCDC40 Gene Sanger sequencing, Se CCDC50 Gene CCDC78 Gene Sanger sequencing, Se CCDC8 Gene Sanger sequencing, Se CCM2 Gene Sanger sequencing, Se CCM2 x2-10 Deletion PCR, gel, Se CCNO Gene (A2LA Cert. No ) Revised 06/28/2018 Page 5 of 38

6 CD320 Gene Sanger sequencing, Se CD40LG Gene Sanger sequencing, Se CDAN1 Gene CDC6 Gene Sanger sequencing, Se CDC73 Gene Sanger sequencing, Se CDH1 Gene Sanger sequencing, Se CDH23 Gene, Sanger sequencing, Se CDHR1 Gene CDK4 Gene Sanger sequencing, Se CDK5RAP2 Gene Sanger sequencing, Se CDKL5 Gene CDKN1B Gene Sanger sequencing, Se CDKN1C Gene Sanger sequencing, Se CDKN2A Gene Sanger sequencing, Se CDON Gene Sanger sequencing, Se CDT1 Gene Sanger sequencing, Se CEBPA Gene Sanger sequencing, Se CENPJ Gene Sanger sequencing, Se CEP152 Gene Sanger sequencing, Se CEP164 Gene CEP290 Gene CEP57 Gene Sanger sequencing, Se CERKL Gene Sanger sequencing, Se CFL2 Gene Sanger sequencing, Se CFTR Gene CHAT Gene Sanger sequencing, Se CHD2 Gene CHD7 Gene Sanger sequencing, Se CHEK2 Gene Sanger sequencing, Se CHKB Gene Sanger sequencing, Se CHM Gene Sanger sequencing, Se CHRDL1 Gene Sanger sequencing, Se CHRNA1 Gene Sanger sequencing, Se CHRNA4 Gene Sanger sequencing, Se CHRNB1 Gene Sanger sequencing, Se CHRNB2 Gene Sanger sequencing, Se CHRND Gene Sanger sequencing, Se CHRNE Gene Sanger sequencing, Se CHRNG Gene Sanger sequencing, Se CHST6 Gene Sanger sequencing, Se CIB2 Gene Sanger sequencing, Se CISD2 Gene Sanger sequencing, Se CLCN5 Gene Sanger sequencing, Se CLCN7 Gene Sanger sequencing, Se CLDN14 Gene Sanger sequencing, Se CLDN16 Gene Sanger sequencing, Se (A2LA Cert. No ) Revised 06/28/2018 Page 6 of 38

7 CLDN19 Gene Sanger sequencing, Se CLN3 Gene Sanger sequencing, Se CLN3 Deletion PCR, gel, Se CLN5 Gene Sanger sequencing, Se CLN6 Gene Sanger sequencing, Se CLN8 Gene Sanger sequencing, Se CLPP Gene Sanger sequencing, Se CLRN1 Gene Sanger sequencing, Se CNGA1 Gene Sanger sequencing, Se CNGA3 Gene Sanger sequencing, Se CNGB1 Gene Sanger sequencing, Se CNGB3 Gene Sanger sequencing, Se CNNM4 Gene CNTN1 Gene Sanger sequencing, Se CNTNAP2 Gene Sanger sequencing, Se COCH Gene Sanger sequencing, Se COG4 Gene Sanger sequencing, Se COL10A1 Gene Sanger sequencing, Se COL11A1 Gene COL11A2 Gene COL12A1 Gene COL17A1 Gene Sanger sequencing, Se COL18A1 Gene Sanger sequencing, Se COL1A1 Gene Sanger sequencing, Se COL1A2 Gene Sanger sequencing, Se COL2A1 Gene Sanger sequencing, Se COL3A1 Gene COL4A3 Gene COL4A4 Gene COL4A5 Gene COL4A6 Gene COL5A1 Gene COL5A2 Gene COL6A1 Gene COL6A2 Gene Sanger sequencing, Se COL6A3 Gene COL7A1 Gene Sanger sequencing, Se COL9A1 Gene COL9A2 Gene COL9A3 Gene COLQ Gene Sanger sequencing, Se COMP Gene Sanger sequencing, Se COMT Gene Sanger sequencing, Se COQ2 Gene Sanger sequencing, Se COQ6 Gene Sanger sequencing, Se COX6A1 Gene Sanger sequencing, Se CP Gene Sanger sequencing, Se (A2LA Cert. No ) Revised 06/28/2018 Page 7 of 38

8 CPA1 Gene Sanger sequencing, Se CPS1 Gene Sanger sequencing, Se CRB1 Gene Sanger sequencing, Se CREBBP Gene CRTAP Gene Sanger sequencing, Se CRX Gene Sanger sequencing, Se CRYAA Gene CRYAB Gene Sanger sequencing, Se CRYBA1 Gene CRYBA4 Gene CRYBB1 Gene CSF3R Gene Sanger sequencing, Se CSRP3 Gene Sanger sequencing, Se CTC1 Gene Sanger sequencing, Se CTDP1 Gene Sanger sequencing, Se CTH Gene Sanger sequencing, Se CTNS Deletion Test PCR, gel, ABI3730xl, Se CTNS Gene Sanger sequencing, Se CTRC Gene Sanger sequencing, Se CTSC Gene Sanger sequencing, Se CTSD Gene Sanger sequencing, Se CTSF Gene Sanger sequencing, Se CUL3 Gene Sanger sequencing, Se CUL4B Gene Sanger sequencing, Se CUL7 Gene Sanger sequencing, Se CXCR4 Gene Sanger sequencing, Se CYB5R3 Gene Sanger sequencing, Se CYBA Gene Sanger sequencing, Se CYBB Gene Sanger sequencing, Se CYCS Gene Sanger sequencing, Se CYP1B1 Gene Sanger sequencing, Se CYP21A2 Gene Sanger sequencing, Se CYP27A1 Gene Sanger sequencing, Se CYP4F22 Gene Sanger sequencing, Se CYP4V2 Gene Sanger sequencing, Se DAG1 Gene Sanger sequencing, Se DBT Gene Sanger sequencing, Se DCHS1 Gene Sanger sequencing, Se DCLRE1C Gene Sanger sequencing, Se DCTN1 Gene DCX Gene Sanger sequencing, Se DDB2 Gene Sanger sequencing, Se DDR2 Gene Sanger sequencing, Se DEPDC5 Gene Sanger sequencing, Se DES Gene Sanger sequencing, Se DFNB31 Gene Sanger sequencing, Se DFNB59 Gene (A2LA Cert. No ) Revised 06/28/2018 Page 8 of 38

9 DGKE Gene Sanger sequencing, Se DGUOK Gene Sanger sequencing, Se DHCR7 Gene Sanger sequencing, Se DHH Gene Sanger sequencing, Se DHODH Gene Sanger sequencing, Se DICER1 Gene DIS3L2 Gene Sanger sequencing, Se DISP1 Gene Sanger sequencing, Se DKC1 Gene Sanger sequencing, Se DLAT Gene Sanger sequencing, Se DLD Gene Sanger sequencing, Se DLL3 Gene Sanger sequencing, Se DLX3 Gene Sanger sequencing, Se DMD Gene DNA2 Gene DNAAF1 Gene Sanger sequencing, Se DNAAF2 Gene Sanger sequencing, Se DNAAF3 Gene Sanger sequencing, Se DNAAF5 Gene DNAH11 Gene DNAH5 Gene DNAH8 Gene DNAI1 Gene Sanger sequencing, Se DNAI2 Gene Sanger sequencing, Se DNAJB6 Gene Sanger sequencing, Se DNAJC5 Gene DNAL1 Gene Sanger sequencing, Se DNFB59 Gene DNM1L Gene DNM2 Gene Sanger sequencing, Se DNMT1 Gene DOCK6 Gene DOCK8 Gene DOK7 Gene Sanger sequencing, Se DPAGT1 Gene Sanger sequencing, Se DPM1 Gene Sanger sequencing, Se DPM3 Gene Sanger sequencing, Se DPYD Gene Sanger sequencing, Se DPYS Gene Sanger sequencing, Se DSC2 Gene Sanger sequencing, Se DSG2 Gene Sanger sequencing, Se DSP Gene DSPP Gene Sanger sequencing, Se DSTYK Gene Sanger sequencing, Se DTNBP1 Gene Sanger sequencing, Se DUOX2 Gene DUOXA2 Gene Sanger sequencing, Se (A2LA Cert. No ) Revised 06/28/2018 Page 9 of 38

10 DYNC1H1 Gene DYNC2H1 Gene DYSF Gene EBP Gene Sanger sequencing, Se ECE1 Gene Sanger sequencing, Se ECEL1 Gene Sanger sequencing, Se EDA Gene Sanger sequencing, Se EDAR Gene Sanger sequencing, Se EDARADD Gene Sanger sequencing, Se EDN3 Gene Sanger sequencing, Se EDNRB Gene Sanger sequencing, Se EFEMP1 Gene Sanger sequencing, Se EFEMP2 Gene Sanger sequencing, Se EFNB1 Gene Sanger sequencing, Se EFTUD2 Gene EGFR Gene Sanger sequencing, Se EHMT1 Gene Sanger sequencing, Se EIF2B1 Gene Sanger sequencing, Se EIF2B2 Gene Sanger sequencing, Se EIF2B3 Gene Sanger sequencing, Se EIF2B4 Gene Sanger sequencing, Se EIF2B5 Gene Sanger sequencing, Se ELANE Gene Sanger sequencing, Se ELN Gene Sanger sequencing, Se ELOVL4 Gene Sanger sequencing, Se EMD Gene Sanger sequencing, Se EMP2 Gene Sanger sequencing, Se ENAM Gene Sanger sequencing, Se ENG Gene Sanger sequencing, Se EP300 Gene EPB42 Gene Sanger sequencing, Se EPCAM Gene Sanger sequencing, Se EPM2A Gene Sanger sequencing, Se EPOR Gene Sanger sequencing, Se ERCC2 Gene Sanger sequencing, Se ERCC3 Gene Sanger sequencing, Se ERCC4 Gene Sanger sequencing, Se ERCC5 Gene Sanger sequencing, Se ERCC6 Gene ERCC8 Gene Sanger sequencing, Se ESCO2 Gene Sanger sequencing, Se ESRRB Gene ETHE1 Gene Sanger sequencing, Se EVC Gene Sanger sequencing, Se EVC2 Gene Sanger sequencing, Se EXOSC3 Gene Sanger sequencing, Se EXT1 Gene Sanger sequencing, Se (A2LA Cert. No ) Revised 06/28/2018 Page 10 of 38

11 EXT2 Gene Sanger sequencing, Se EYA1 Gene Sanger sequencing, Se EYA4 Gene EZH2 Gene Sanger sequencing, Se F11 Gene Sanger sequencing, Se F2 Gene Sanger sequencing, Se F5 Gene F7 Gene F8 Gene F9 Gene Sanger sequencing, Se F13A1 F13B FAH Gene Sanger sequencing, Se FAM111B Gene Sanger sequencing, Se FAM126A Gene Sanger sequencing, Se FAM20A Gene Sanger sequencing, Se FAM83H Gene Sanger sequencing, Se FAN1 Gene Sanger sequencing, Se FANCA Gene FANCB Gene Sanger sequencing, Se FANCC Gene Sanger sequencing, Se FANCD2 Gene FANCE Gene Sanger sequencing, Se FANCF Gene Sanger sequencing, Se FANCG Gene Sanger sequencing, Se FANCI Gene FANCL Gene Sanger sequencing, Se FANCM Gene FARS2 Gene FAS Gene Sanger sequencing, Se FBN1 Gene FBN2 Gene FBP1 Gene Sanger sequencing, Se FBXL4 Gene Sanger sequencing, Se FECH Gene Sanger sequencing, Se FERMT1 Gene Sanger sequencing, Se FGA Gene Sanger sequencing, Se FGD1 Gene Sanger sequencing, Se FGF3 Gene FGFR1 Gene Sanger sequencing, Se FGFR2 Gene Sanger sequencing, Se FGFR3 Gene Sanger sequencing, Se FGG Gene Sanger sequencing, Se FH Gene Sanger sequencing, Se FHL1 Gene Sanger sequencing, Se FIG4 Gene (A2LA Cert. No ) Revised 06/28/2018 Page 11 of 38

12 Fingerprint for Identification, Se FKBP10 Gene Sanger sequencing, Se FKBP14 Gene Sanger sequencing, Se FKRP Gene Sanger sequencing, Se FKTN Gene Sanger sequencing, Se FKTN Insertion, Se FLCN Gene Sanger sequencing, Se FLNA Gene Sanger sequencing, Se FLNB Gene Sanger sequencing, Se FLNC Gene FLT4 Gene FMO3 Gene Sanger sequencing, Se FMR1 CGG Repeat Expansion Repeat-primed PCR, Se FMR1 Gene Sanger sequencing, Se FMR1 methylation Methylation-sensitive status PCR, Se FOLR1 Gene Sanger sequencing, Se FOXC1 Gene Sanger sequencing, Se FOXC2 Gene Sanger sequencing, Se FOXE3 Gene Sanger sequencing, Se FOXG1 Gene Sanger sequencing, Se FOXH1 Gene Sanger sequencing, Se FOXI1 Gene Sanger sequencing, Se FOXL2 Gene Sanger sequencing, Se FOXP3 Gene Sanger sequencing, Se FRMD7 Gene Sanger sequencing, Se FSHB Gene Sanger sequencing, Se FSHR Gene Sanger sequencing, Se FUS Gene Sanger sequencing, Se FZD4 Gene Sanger sequencing, Se G6PC Gene Sanger sequencing, Se G6PC3 Gene Sanger sequencing, Se G6PD Gene Sanger sequencing, Se GAA Gene Sanger sequencing, Se GABRA1 Gene Sanger sequencing, Se GABRB3 Gene GABRG2 Gene GALC Gene Sanger sequencing, Se GALC x11-17 Deletion PCR, gel, Se GALE Gene Sanger sequencing, Se GALK1 Gene Sanger sequencing, Se GALNS Gene Sanger sequencing, Se GALT deletion PCR, gel, Se GALT Gene Sanger sequencing, Se (A2LA Cert. No ) Revised 06/28/2018 Page 12 of 38

13 GAMT Gene Sanger sequencing, Se GAN Gene Sanger sequencing, Se GARS Gene Sanger sequencing, Se GAS1 Gene Sanger sequencing, Se GATA1 Gene Sanger sequencing, Se GATA2 Gene Sanger sequencing, Se GATA3 Gene Sanger sequencing, Se GATA4 Gene Sanger sequencing, Se GATM Gene Sanger sequencing, Se GBA Gene Sanger sequencing, Se GBE1 Gene Sanger sequencing, Se GCDH Gene Sanger sequencing, Se GCH1 Gene Sanger sequencing, Se GCK Gene Sanger sequencing, Se GCM2 Gene Sanger sequencing, Se GDF1 Gene Sanger sequencing, Se GDF5 Gene Sanger sequencing, Se GDF6 Gene Sanger sequencing, Se GDNF Gene Sanger sequencing, Se GFI1 Gene Sanger sequencing, Se GFPT1 Gene Sanger sequencing, Se GHR Gene Sanger sequencing, Se GHSR Gene Sanger sequencing, Se GIPC3 Gene GJA1 Gene Sanger sequencing, Se GJA5 Gene Sanger sequencing, Se GJB2 Gene Sanger sequencing, Se GJC2 Gene Sanger sequencing, Se GLA Gene Sanger sequencing, Se GLB1 Gene Sanger sequencing, Se GLDC Gene Sanger sequencing, Se GLE1 Gene Sanger sequencing, Se GLI2 Gene Sanger sequencing, Se GLI3 Gene Sanger sequencing, Se GLIS2 Gene Sanger sequencing, Se GLIS3 Gene Sanger sequencing, Se GLUD1 Gene Sanger sequencing, Se GM2A Gene Sanger sequencing, Se GMPPB Gene Sanger sequencing, Se GNA11 Gene Sanger sequencing, Se GNAT2 Gene Sanger sequencing, Se GNE Gene Sanger sequencing, Se GNPAT Gene Sanger sequencing, Se GNPTAB Gene Sanger sequencing, Se GNPTG Gene Sanger sequencing, Se GNRH1 Gene Sanger sequencing, Se GNRHR Gene Sanger sequencing, Se (A2LA Cert. No ) Revised 06/28/2018 Page 13 of 38

14 GNS Gene Sanger sequencing, Se GORAB Gene Sanger sequencing, Se GOSR2 Gene GP1BA Gene Sanger sequencing, Se GP1BB Gene Sanger sequencing, Se GP6 Gene GP9 Gene Sanger sequencing, Se GPC3 Gene Sanger sequencing, Se GPD1L Gene Sanger sequencing, Se GPHN Gene Sanger sequencing, Se GPI Gene Sanger sequencing, Se GPR56 Gene Sanger sequencing, Se GPR143 Gene GRIN2A Gene GRHPR Gene Sanger sequencing, Se GRN Gene Sanger sequencing, Se GSN Gene Sanger sequencing, Se GSS Gene Sanger sequencing, Se GUCA1A Gene Sanger sequencing, Se GUCA1B Gene Sanger sequencing, Se GUCY2D Gene Sanger sequencing, Se GUSB Gene Sanger sequencing, Se GYS2 Gene Sanger sequencing, Se HADH Gene Sanger sequencing, Se HAMP Gene Sanger sequencing, Se HARS2 Gene Sanger sequencing, Se HAX1 Gene Sanger sequencing, Se HBB Gene Sanger sequencing, Se HCN4 Gene Sanger sequencing, Se HDAC8 Gene Sanger sequencing, Se HEPACAM Gene Sanger sequencing, Se HES7 Gene Sanger sequencing, Se HESX1 Gene Sanger sequencing, Se HEXA Gene Sanger sequencing, Se HEXB Gene Sanger sequencing, Se HFE Gene Sanger sequencing, Se HFE2 Gene Sanger sequencing, Se HGD Gene Sanger sequencing, Se HGSNAT Gene Sanger sequencing, Se HINT1 Gene Sanger sequencing, Se HLCS Gene Sanger sequencing, Se HMBS Gene Sanger sequencing, Se HMGCL Gene Sanger sequencing, Se HNF1A Gene Sanger sequencing, Se HNF1B Gene Sanger sequencing, Se HNF4A Gene Sanger sequencing, Se hnrnpa1 Gene Sanger sequencing, Se (A2LA Cert. No ) Revised 06/28/2018 Page 14 of 38

15 HPRT1 Gene Sanger sequencing, Se HPS1 Gene Sanger sequencing, Se HPS3 Gene Sanger sequencing, Se HPS3 Exon 1 Deletion Test PCR, gel, Se HPS4 Gene Sanger sequencing, Se HPS5 Gene HPS6 Gene Sanger sequencing, Se HPSE2 Gene Sanger sequencing, Se HRAS Gene Sanger sequencing, Se HSD11B2 Gene Sanger sequencing, Se HSD17B3 Gene Sanger sequencing, Se HSD17B4 Gene Sanger sequencing, Se HSD3B7 Gene HSPB1 Gene Sanger sequencing, Se HSPB8 Gene Sanger sequencing, Se HTT Expansion Test Repeat-primed PCR and Fluorescent Fragment-, Se Length Assay HYAL1 Gene Sanger sequencing, Se IDS Gene Sanger sequencing, Se IDUA Gene Sanger sequencing, Se IFITM5 Gene Sanger sequencing, Se IFT122 Gene Sanger sequencing, Se IGHMBP2 Gene Sanger sequencing, Se IGSF1 Gene Sanger sequencing, Se IKBKAP Gene Sanger sequencing, Se IL11RA Gene Sanger sequencing, Se IL12RB1 Gene Sanger sequencing, Se IL2RG Gene Sanger sequencing, Se IL7R Gene Sanger sequencing, Se ILDR1 Gene IMPDH1 Gene Sanger sequencing, Se INPP5E Gene Sanger sequencing, Se INS Gene Sanger sequencing, Se INVS Gene Sanger sequencing, Se IQCB1 Gene Sanger sequencing, Se IRF6 Gene Sanger sequencing, Se ISPD Gene Sanger sequencing, Se ITGA2B Gene Sanger sequencing, Se ITGA3 Gene Sanger sequencing, Se ITGA6 Gene Sanger sequencing, Se ITGA7 Gene Sanger sequencing, Se ITGB3 Gene Sanger sequencing, Se ITGB4 Gene Sanger sequencing, Se IVD Gene Sanger sequencing, Se IYD Gene Sanger sequencing, Se (A2LA Cert. No ) Revised 06/28/2018 Page 15 of 38

16 JAG1 Gene Sanger sequencing, Se JUP Gene Sanger sequencing, Se KAT6B Gene KBTBD13 Gene Sanger sequencing, Se KCNA5 Gene Sanger sequencing, Se KCND3 Gene KCNE1 Gene Sanger sequencing, Se KCNE2 Gene Sanger sequencing, Se KCNE3 Gene Sanger sequencing, Se KCNH1 Gene Sanger sequencing, Se KCNH2 Gene Sanger sequencing, Se KCNJ1 Gene Sanger sequencing, Se KCNJ10 Gene Sanger sequencing, Se KCNJ11 Gene Sanger sequencing, Se KCNJ2 Gene Sanger sequencing, Se KCNJ5 Gene Sanger sequencing, Se KCNQ1 Gene Sanger sequencing, Se KCNQ2 Gene Sanger sequencing, Se KCNQ3 Gene Sanger sequencing, Se KCNQ4 Gene Sanger sequencing, Se KCNT1 Gene KCNV2 Gene Sanger sequencing, Se KCTD7 Gene Sanger sequencing, Se KDM6A Gene KIF11 Gene Sanger sequencing, Se KIF1B Gene Sanger sequencing, Se KIF1BP Gene Sanger sequencing, Se KIF7 Gene KISS1 Gene Sanger sequencing, Se KISS1R Gene Sanger sequencing, Se KIT Gene Sanger sequencing, Se KLF1 Gene KLF11 Gene Sanger sequencing, Se KLHL3 Gene Sanger sequencing, Se KLHL40 Gene Sanger sequencing, Se KLHL41 Gene Sanger sequencing, Se KLK4 Gene Sanger sequencing, Se KMT2A Gene Sanger sequencing, Se KMT2D Gene KRAS Gene Sanger sequencing, Se KRIT1 Gene Sanger sequencing, Se KRT14 Gene Sanger sequencing, Se KRT5 Gene Sanger sequencing, Se KRT85 Gene Sanger sequencing, Se L1CAM Gene Sanger sequencing, Se LAMA2 Gene LAMA3 Gene Sanger sequencing, Se (A2LA Cert. No ) Revised 06/28/2018 Page 16 of 38

17 LAMA4 Gene Sanger sequencing, Se LAMB2 Gene LAMB3 Gene Sanger sequencing, Se LAMC2 Gene Sanger sequencing, Se LAMP2 Gene Sanger sequencing, Se LARGE Gene Sanger sequencing, Se LARP7 Gene Sanger sequencing, Se LARS2 Gene Sanger sequencing, Se LBR Gene Sanger sequencing, Se LCAT Gene Sanger sequencing, Se LDB3 Gene Sanger sequencing, Se LDLR Gene Sanger sequencing, Se LEFTY2 Gene Sanger sequencing, Se LEPRE1 Gene Sanger sequencing, Se LFNG Gene Sanger sequencing, Se LHCGR Gene Sanger sequencing, Se LHX4 Gene Sanger sequencing, Se LIAS Gene Sanger sequencing, Se LIG4 Gene Sanger sequencing, Se LIMS2 Gene Sanger sequencing, Se LIPA Gene Sanger sequencing, Se LMAN1 Gene LMBRD1 Gene Sanger sequencing, Se LMNA Gene Sanger sequencing, Se LMX1B Gene Sanger sequencing, Se LOXHD1 Gene LPIN1 Gene Sanger sequencing, Se LPIN1x18-19 Deletion PCR, gel, Se LPIN2 Gene LRAT Gene Sanger sequencing, Se LRIG2 Gene Sanger sequencing, Se LRPPRC Gene Sanger sequencing, Se LRRC6 Gene Sanger sequencing, Se LRTOMT Gene Sanger sequencing, Se LTBP2 Gene LYST Gene MAF Gene Sanger sequencing, Se MAN2B1 Gene Sanger sequencing, Se MAP2K1 Gene Sanger sequencing, Se MAP2K2 Gene Sanger sequencing, Se MARVELD2 Gene MASTL Gene Sanger sequencing, Se MAT1A Gene Sanger sequencing, Se MATN3 Gene Sanger sequencing, Se MATR3 Gene Sanger sequencing, Se MAX Gene Sanger sequencing, Se (A2LA Cert. No ) Revised 06/28/2018 Page 17 of 38

18 MBD5 Gene MC4R Gene Sanger sequencing, Se MCCC1 Gene Sanger sequencing, Se MCCC2 Gene Sanger sequencing, Se MCFD2 Gene MCOLN1 Gene Sanger sequencing, Se MCOLN1 x1-6 Deletion PCR, gel, Se MCPH1 Gene Sanger sequencing, Se MECP2 Gene Sanger sequencing, Se MED12 Gene Sanger sequencing, Se MEF2C Gene MEFV Gene Sanger sequencing, Se MEGF10 Gene Sanger sequencing, Se MEN1 Gene Sanger sequencing, Se MEOX1 Gene Sanger sequencing, Se MERTK Gene Sanger sequencing, Se MESP2 Gene Sanger sequencing, Se MET Gene MFN2 Gene Sanger sequencing, Se MFRP Gene Sanger sequencing, Se MFSD8 Gene MITF Gene Sanger sequencing, Se MKKS Gene Sanger sequencing, Se MKS1 Gene Sanger sequencing, Se MLC1 Gene Sanger sequencing, Se MLH1 Gene Sanger sequencing, Se MLH3 Gene Sanger sequencing, Se MMAA Gene Sanger sequencing, Se MMAB Gene Sanger sequencing, Se MMACHC Gene Sanger sequencing, Se MMADHC Gene Sanger sequencing, Se MMP13 Gene Sanger sequencing, Se MMP20 Gene Sanger sequencing, Se MPDU1 Gene Sanger sequencing, Se MPI Gene Sanger sequencing, Se MPL Gene Sanger sequencing, Se MPV17 Gene Sanger sequencing, Se MPZ Gene Sanger sequencing, Se MRE11A Gene Sanger sequencing, Se MRPL3 Gene Sanger sequencing, Se MSH2 Gene Sanger sequencing, Se MSH6 Gene Sanger sequencing, Se MSX2 Gene Sanger sequencing, Se MTM1 Gene Sanger sequencing, Se MTPAP Gene MTR Gene Sanger sequencing, Se (A2LA Cert. No ) Revised 06/28/2018 Page 18 of 38

19 MTRR Gene Sanger sequencing, Se MUSK Gene Sanger sequencing, Se MUT Gene Sanger sequencing, Se MUTYH Gene Sanger sequencing, Se MVK Gene Sanger sequencing, Se MYBPC3 Gene MYF6 Gene Sanger sequencing, Se MYH11 Gene MYH14 Gene MYH2 Gene Sanger sequencing, Se MYH3 Gene MYH6 Gene MYH7 Gene MYH9 Gene Sanger sequencing,, Se MYL2 Gene Sanger sequencing, Se MYL3 Gene Sanger sequencing, Se MYLK Gene MYO3A Gene MYO5A Gene MYO6 Gene MYO7A Gene MYOC Gene Sanger sequencing, Se MYOT Gene Sanger sequencing, Se NAA10 Gene Sanger sequencing, Se NAGLU Gene Sanger sequencing, Se NAGPA Gene Sanger sequencing, Se NAGS Gene Sanger sequencing, Se NBEAL2 Gene Sanger sequencing, Se NBN Gene Sanger sequencing, Se NCF2 Gene Sanger sequencing, Se NCF4 Gene NDP Gene Sanger sequencing, Se NDUFA2 Gene Sanger sequencing, Se NDUFAF6 Gene Sanger sequencing, Se NDUFS1 Gene NEB Gene NEB Gene Exon 55 Deletion PCR, gel, Se NEK8 Gene Sanger sequencing, Se NEUROD1 Gene Sanger sequencing, Se NEXN Gene Sanger sequencing, Se NF1 Gene Sanger sequencing, MLPA, Se NF2 Gene Sanger sequencing, Se NGF Gene Sanger sequencing, Se NHLRC1 Gene Sanger sequencing, Se (A2LA Cert. No ) Revised 06/28/2018 Page 19 of 38

20 NHP2 Gene Sanger sequencing, Se NHS Gene Sanger sequencing, Se NIPAL4 Gene Sanger sequencing, Se NIPBL Gene NKX2-1 Gene Sanger sequencing, Se NKX2-5 Gene Sanger sequencing, Se NLRP12 Gene NLRP3 Gene Sanger sequencing, Se NME8 Gene Sanger sequencing, Se NODAL Gene Sanger sequencing, Se NOG Gene Sanger sequencing, Se NOP10 Gene Sanger sequencing, Se NOTCH2 Gene NOTCH3 Gene Sanger sequencing, Se NPC1 Gene Sanger sequencing, Se NPC2 Gene Sanger sequencing, Se NPHP1 Gene Sanger sequencing, Se NPHP3 Gene Sanger sequencing, Se NPHP4 Gene Sanger sequencing, Se NPHS1 Gene NPHS2 Gene Sanger sequencing, Se NR0B1 Gene Sanger sequencing, Se NR2E3 Gene Sanger sequencing, Se NR2F1 Gene Sanger sequencing, Se NR3C2 Gene Sanger sequencing, Se NR5A1 Gene Sanger sequencing, Se NRAS Gene Sanger sequencing, Se NRL Gene Sanger sequencing, Se NRTN Gene Sanger sequencing, Se NRXN1 Gene Sanger sequencing, Se NSD1 Gene Sanger sequencing, Se NSDHL Gene Sanger sequencing, Se NYX Gene Sanger sequencing, Se OCA2 Gene OCA2 deletion PCR, gel, Se OCRL Gene Sanger sequencing, Se OFD1 Gene Sanger sequencing, Se OPA1 Gene OPA3 Gene Sanger sequencing, Se OPHN1 Gene Sanger sequencing, Se OPTN Gene Sanger sequencing, Se ORC1 Gene Sanger sequencing, Se ORC4 Gene Sanger sequencing, Se ORC6 Gene Sanger sequencing, Se OSTM1 Gene Sanger sequencing, Se OTC Gene Sanger sequencing, Se OTOA Gene (A2LA Cert. No ) Revised 06/28/2018 Page 20 of 38

21 OTOF Gene OTX2 Gene Sanger sequencing, Se OXCT1 Gene Sanger sequencing, Se P2RY12 Gene PAFAH1B1 Gene Sanger sequencing, Se PAH Gene Sanger sequencing, Se PALB2 Gene Sanger sequencing, Se PARK2 Gene Sanger sequencing, Se PARK7 Gene Sanger sequencing, Se PAX2 Gene Sanger sequencing, Se PAX3 Gene Sanger sequencing, Se PAX4 Gene Sanger sequencing, Se PAX6 Gene Sanger sequencing, Se PAX8 Gene Sanger sequencing, Se PAX9 Gene Sanger sequencing, Se PC Gene Sanger sequencing, Se PCBD1 Gene Sanger sequencing, Se PCCA Gene Sanger sequencing, Se PCCB Gene Sanger sequencing, Se PCDH15 Gene PCDH19 Gene Sanger sequencing, Se PCK1 Gene Sanger sequencing, Se PCK2 Gene Sanger sequencing, Se PCSK9 Gene Sanger sequencing, Se PDCD10 Gene Sanger sequencing, Se PDE11A Gene Sanger sequencing, Se PDE6A Gene Sanger sequencing, Se PDE6B Gene Sanger sequencing, Se PDE6C Gene Sanger sequencing, Se PDGFRA Gene Sanger sequencing, Se PDGFRB Gene Sanger sequencing, Se PDHA1 Gene Sanger sequencing, Se PDHB Gene Sanger sequencing, Se PDHX Gene Sanger sequencing, Se PDP1 Gene Sanger sequencing, Se PDX1 Gene Sanger sequencing, Se PDZD7 Gene Sanger sequencing, Se PEX1 Gene PEX10 Gene Sanger sequencing, Se PEX11B Gene PEX12 Gene Sanger sequencing, Se PEX13 Gene Sanger sequencing, Se PEX14 Gene Sanger sequencing, Se PEX16 Gene Sanger sequencing, Se PEX19 Gene Sanger sequencing, Se PEX2 Gene Sanger sequencing, Se PEX26 Gene Sanger sequencing, Se (A2LA Cert. No ) Revised 06/28/2018 Page 21 of 38

22 PEX3 Gene Sanger sequencing, Se PEX5 Gene Sanger sequencing, Se PEX6 Gene Sanger sequencing, Se PEX7 Gene Sanger sequencing, Se PFKM Gene Sanger sequencing, Se PFN1 Gene Sanger sequencing, Se PGxome PGK1 Gene Sanger sequencing, Se PHEX Gene Sanger sequencing, Se PHGDH Gene Sanger sequencing, Se PHKA1 Gene PHKA2 Gene PHKB Gene PHKG2 Gene Sanger sequencing, Se PHOX2A Gene Sanger sequencing, Se PHOX2B Gene Sanger sequencing, Se PHYH Gene Sanger sequencing, Se PIGO Gene PIK3CA Gene Sanger sequencing, Se PIK3CD Gene Sanger sequencing, Se PINK1 Gene Sanger sequencing, Se PITPNM3 Gene PITX2 Gene Sanger sequencing, Se PITX3 Gene Sanger sequencing, Se PKD1 Gene PKD2 Gene Sanger sequencing, Se PKHD1 Gene PKLR Gene Sanger sequencing, Se PKP1 Gene Sanger sequencing, Se PKP2 Gene Sanger sequencing, Se PLCB1 Gene PLCE1 Gene PLEC Gene Sanger sequencing, Se PLN Gene Sanger sequencing, Se PLOD1 Gene Sanger sequencing, Se PLOD2 Gene Sanger sequencing, Se PLP1 Gene Sanger sequencing, Se PMM2 Gene Sanger sequencing, Se PMP22 Gene Sanger sequencing, Se PMS1 Gene Sanger sequencing, Se PMS2 Gene Sanger sequencing, Se PNKD Gene Sanger sequencing, Se PNKP Gene PNPLA1 Gene Sanger sequencing, Se PNPLA2 Gene Sanger sequencing, Se PNPO Gene POC1A Gene Sanger sequencing, Se (A2LA Cert. No ) Revised 06/28/2018 Page 22 of 38

23 POLD1 Gene Sanger sequencing, Se POLE Gene Sanger sequencing, Se POLG Gene Sanger sequencing, Se POLG2 Gene Sanger sequencing, Se POLH Gene Sanger sequencing, Se POLR1C Gene Sanger sequencing, Se POLR1D Gene Sanger sequencing, Se POMGNT1 Gene Sanger sequencing, Se POMGNT2 Gene Sanger sequencing, Se POMK Gene Sanger sequencing, Se POMP Gene Sanger sequencing, Se POMT1 Gene Sanger sequencing, Se POMT2 Gene Sanger sequencing, Se POR Gene Sanger sequencing, Se PORCN Gene Sanger sequencing, Se POU3F4 Gene Sanger sequencing, Se POU4F3 Gene PPT1 Gene Sanger sequencing, Se PRF1 Gene Sanger sequencing, Se PRKAG2 Gene Sanger sequencing, Se PRKAR1A Gene Sanger sequencing, Se PRKCSH Gene Sanger sequencing, Se PROC Gene Sanger sequencing, Se PROM1 Gene PROS1 Gene Sanger sequencing, Se PRPF3 Gene Sanger sequencing, Se PRPF31 Gene Sanger sequencing, Se PRPF8 Gene Sanger sequencing, Se PRPH2 Gene Sanger sequencing, Se PRPS1 Gene Sanger sequencing, Se PRRT2 Gene Sanger sequencing, Se PRRX1 Gene Sanger sequencing, Se PRSS1 Gene Sanger sequencing, Se PRSS56 Gene Sanger sequencing, Se PSAP Gene Sanger sequencing, Se PSEN1 Gene Sanger sequencing, Se PSEN2 Gene Sanger sequencing, Se PTCH1 Gene Sanger sequencing, Se PTEN Gene Sanger sequencing, Se PTH Gene Sanger sequencing, Se PTPN11 Gene Sanger sequencing, Se PTS Gene Sanger sequencing, Se PYCR1 Gene Sanger sequencing, Se PYGL Gene Sanger sequencing, Se PYGM Gene Sanger sequencing, Se QDPR Gene Sanger sequencing, Se RAB27A Gene Sanger sequencing, Se (A2LA Cert. No ) Revised 06/28/2018 Page 23 of 38

24 RAB7A Gene Sanger sequencing, Se RAD21 Gene Sanger sequencing, Se RAD50 Gene Sanger sequencing, Se RAD51C Gene Sanger sequencing, Se RAD51D Gene Sanger sequencing, Se RAF1 Gene Sanger sequencing, Se RAG1 Gene Sanger sequencing, Se RAG2 Gene Sanger sequencing, Se RAI1 Gene Sanger sequencing, Se RAPSN Gene Sanger sequencing, Se RARS2 Gene Sanger sequencing, Se RAX2 Gene Sanger sequencing, Se RB1 Gene Sanger sequencing, Se RBM20 Gene Sanger sequencing, Se RDH12 Gene Sanger sequencing, Se RDH5 Gene RDX Gene Sanger sequencing, Se RECQL4 Gene Sanger sequencing, Se REEP1 Gene Sanger sequencing, Se RELN Gene Sanger sequencing, Se REN Gene Sanger sequencing, Se RET Gene Sanger sequencing, Se RHO Gene Sanger sequencing, Se RIN2 Gene Sanger sequencing, Se RIPK4 Gene Sanger sequencing, Se RIT1 Gene Sanger sequencing, Se RLBP1 Gene Sanger sequencing, Se RMRP Gene Sanger sequencing, Se ROGDI Gene Sanger sequencing, Se ROR2 Gene Sanger sequencing, Se RP1 Gene Sanger sequencing, Se RP2 Gene Sanger sequencing, Se RPE65 Gene Sanger sequencing, Se RPGR Gene Sanger sequencing, Se RPGRIP1 Gene RPGRIP1L Gene RRM2B Gene Sanger sequencing, Se RS1 Gene Sanger sequencing, Se RSPH4A Gene Sanger sequencing, Se RSPH9 Gene Sanger sequencing, Se RUNX1 Gene Sanger sequencing, Se RUNX2 Gene Sanger sequencing, Se RYR1 Gene RYR2 Gene SACS Gene Sanger sequencing, Se SAG Gene Sanger sequencing, Se SALL1 Gene Sanger sequencing, Se (A2LA Cert. No ) Revised 06/28/2018 Page 24 of 38

25 SALL4 Gene Sanger sequencing, Se SBDS Gene Sanger sequencing, Se SCARB2 Gene Sanger sequencing, Se SCN10A Gene Sanger sequencing, Se SCN11A Gene Sanger sequencing, Se SCN1A Gene SCN1B Gene Sanger sequencing, Se SCN2A Gene SCN2B Gene SCN3B Gene Sanger sequencing, Se SCN4A Gene SCN4B Gene Sanger sequencing, Se SCN5A Gene SCN8A Gene SCN9A Gene SCNN1A Gene Sanger sequencing, Se SCNN1B Gene Sanger sequencing, Se SCNN1G Gene Sanger sequencing, Se SDCCAG8 Gene Sanger sequencing, Se SDHA Gene Sanger sequencing, Se SDHAF2 Gene Sanger sequencing, Se SDHB Gene Sanger sequencing, Se SDHC Gene Sanger sequencing, Se SDHD Gene Sanger sequencing, Se SEC23B Gene SEC63 Gene SECISBP2 Gene Sanger sequencing, Se SEMA3E Gene Sanger sequencing, Se SEMA4A Gene Sanger sequencing, Se SEPN1 Gene Sanger sequencing, Se SERPINA1 Gene Sanger sequencing, Se SERPINC1 Gene Sanger sequencing, Se SERPINF1 Gene Sanger sequencing, Se SERPINF2 Gene SERPING1 Gene Sanger sequencing, Se SERPINH1 Gene Sanger sequencing, Se SETX Gene SF3B4 Gene Sanger sequencing, Se SFTPB Gene Sanger sequencing, Se SFTPC Gene Sanger sequencing, Se SGCA Gene Sanger sequencing, Se SGCB Gene Sanger sequencing, Se SGCD Gene Sanger sequencing, Se SGCE Gene Sanger sequencing, Se SGCG Gene Sanger sequencing, Se SGSH Gene Sanger sequencing, Se SH2D1A Gene Sanger sequencing, Se (A2LA Cert. No ) Revised 06/28/2018 Page 25 of 38

26 SH3BP2 Gene Sanger sequencing, Se SHANK3 Gene Sanger sequencing, Se SHH Gene Sanger sequencing, Se SHOC2 Gene Sanger sequencing, Se SHOX Gene Sanger sequencing, Se SIL1 Gene Sanger sequencing, Se SIX1 Gene Sanger sequencing, Se SIX2 Gene Sanger sequencing, Se SIX3 Gene Sanger sequencing, Se SIX5 Gene Sanger sequencing, Se SKI Gene Sanger sequencing, Se SLC12A1 Gene Sanger sequencing, Se SLC12A3 Gene Sanger sequencing, Se SLC12A6 Gene Sanger sequencing, Se SLC16A2 Gene Sanger sequencing, Se SLC17A5 Gene Sanger sequencing, Se SLC19A2 Gene Sanger sequencing, Se SLC19A3 Gene SLC24A1 Gene SLC24A5 Gene SLC25A3 Gene Sanger sequencing, Se SLC25A4 Gene Sanger sequencing, Se SLC25A22 Gene Sanger sequencing, Se SLC26A2 Gene Sanger sequencing, Se SLC26A4 Gene Sanger sequencing, Se SLC2A1 Gene Sanger sequencing, Se SLC2A10 Gene Sanger sequencing, Se SLC2A2 Gene Sanger sequencing, Se SLC2A9 Gene Sanger sequencing, Se SLC35C1 Gene Sanger sequencing, Se SLC37A4 Gene Sanger sequencing, Se SLC38A8 Gene Sanger sequencing, Se SLC4A1 Gene SLC4A11 Gene Sanger sequencing, Se SLC40A1 Gene Sanger sequencing, Se SLC45A2 Gene SLC52A2 Gene Sanger sequencing, Se SLC52A3 Gene Sanger sequencing, Se SLC5A5 Gene Sanger sequencing, Se SLC5A7 Gene Sanger sequencing, Se SLC9A6 Gene Sanger sequencing, Se SLCO1B1 Gene Sanger sequencing, Se SLCO1B3 Gene Sanger sequencing, Se SLX4 Gene Sanger sequencing, Se SMAD3 Gene Sanger sequencing, Se SMAD4 Gene Sanger sequencing, Se SMARCA4 Gene (A2LA Cert. No ) Revised 06/28/2018 Page 26 of 38

27 SMARCAL1 Gene Sanger sequencing, Se SMARCB1 Gene Sanger sequencing, Se SMARCE1 Gene Sanger sequencing, Se SMC1A Gene Sanger sequencing, Se SMC3 Gene SMCHD1 Gene SMPD1 Gene Sanger sequencing, Se SNAI2 Gene Sanger sequencing, Se SNTA1 Gene Sanger sequencing, Se SNX10 Gene Sanger sequencing, Se SOD1 Gene Sanger sequencing, Se SOS1 Gene Sanger sequencing, Se SOX10 Gene Sanger sequencing, Se SOX18 Gene Sanger sequencing, Se SOX2 Gene Sanger sequencing, Se SP7 Gene Sanger sequencing, Se SPATA16 Gene Sanger sequencing, Se SPG7 Gene Sanger sequencing, Se SPINK1 Gene Sanger sequencing, Se SPINK5 Gene SPR Gene Sanger sequencing, Se SPRED1 Gene Sanger sequencing, Se SPTA1 Gene SPTAN1 Gene SPTB Gene SQSTM1 Gene Sanger sequencing, Se SRCAP Gene SRY Gene Sanger sequencing, Se ST3GAL3 Gene ST3GAL5 Gene Sanger sequencing, Se STAC3 Gene Sanger sequencing, Se STAT3 Gene STIL Gene Sanger sequencing, Se STIM1 Gene Sanger sequencing, Se STK11 Gene Sanger sequencing, MLPA, Se STX11 Gene Sanger sequencing, Se STXBP1 Gene Sanger sequencing, Se STXBP2 Gene Sanger sequencing, Se SUCLA2 Gene Sanger sequencing, Se SUCLG1 Gene Sanger sequencing, Se SUCLG2 Gene Sanger sequencing, Se SUFU Gene Sanger sequencing, Se SUMF1 Gene Sanger sequencing, Se SUOX Gene Sanger sequencing, Se SURF1 Gene Sanger sequencing, Se SYNE1 Gene (A2LA Cert. No ) Revised 06/28/2018 Page 27 of 38

28 SZT2 Gene TAC3 Gene Sanger sequencing, Se TACO1 Gene Sanger sequencing, Se TACR3 Gene Sanger sequencing, Se TACSTD2 Gene Sanger sequencing, Se TARDBP Gene Sanger sequencing, Se TAT Gene Sanger sequencing, Se TAZ Gene Sanger sequencing, Se TBC1D24 Gene TBX3 Gene Sanger sequencing, Se TBX4 Gene Sanger sequencing, Se TBX5 Gene Sanger sequencing, Se TBX6 Gene Sanger sequencing, Se TBXA2R Gene Sanger sequencing, Se TCAP Gene Sanger sequencing, Se TCF4 Gene Sanger sequencing, Se TCF12 Gene Sanger sequencing, Se TCIRG1 Gene Sanger sequencing, Se TCOF1 Gene TCTN1 Gene Sanger sequencing, Se TCTN2 Gene Sanger sequencing, Se TECTA Gene Sanger sequencing, Se TERT Gene Sanger sequencing, Se TFAP2A Gene Sanger sequencing, Se TFAP2B Gene Sanger sequencing, Se TFR2 Gene TG Gene TGFB1 Gene Sanger sequencing, Se TGFB2 Gene Sanger sequencing, Se TGFBI Gene Sanger sequencing, Se TGFBR1 Gene Sanger sequencing, Se TGFBR2 Gene Sanger sequencing, Se TGIF Gene Sanger sequencing, Se TGM1 Gene Sanger sequencing, Se TGM5 Gene Sanger sequencing, Se TH Gene Sanger sequencing, Se THPO Gene Sanger sequencing, Se THRA Gene Sanger sequencing, Se TIA1 Gene Sanger sequencing, Se TIMM8A Gene Sanger sequencing, Se TIMP3 Gene Sanger sequencing, Se TINF2 Gene Sanger sequencing, Se TK2 Gene Sanger sequencing, Se TMC1 Gene Sanger sequencing, Se TMEM126A Gene Sanger sequencing, Se TMEM127 Gene Sanger sequencing, Se TMEM138 Gene Sanger sequencing, Se (A2LA Cert. No ) Revised 06/28/2018 Page 28 of 38

29 TMEM216 Gene Sanger sequencing, Se TMEM237 Gene Sanger sequencing, Se TMEM43 Gene Sanger sequencing, Se TMEM5 Gene Sanger sequencing, Se TMEM67 Gene Sanger sequencing, Se TMIE Gene Sanger sequencing, Se TMPRSS3 Gene Sanger sequencing, Se TMPRSS6 Gene Sanger sequencing, Se TNFRSF11A Gene Sanger sequencing, Se TNFRSF11B Gene Sanger sequencing, Se TNFRSF13B Gene Sanger sequencing, Se TNFRSF1A Gene Sanger sequencing, Se TNNC1 Gene Sanger sequencing, Se TNNI2 Gene Sanger sequencing, Se TNNI3 Gene Sanger sequencing, Se TNNT1 Gene Sanger sequencing, Se TNNT2 Gene Sanger sequencing, Se TNNT3 Gene Sanger sequencing, Se TNPO3 Gene Sanger sequencing, Se TNXB Gene Sanger sequencing, Se TOPORS Gene Sanger sequencing, Se TOR1A Gene Sanger sequencing, Se TP53 Gene Sanger sequencing, Se TP63 Gene Sanger sequencing, Se TPI1 Gene Sanger sequencing, Se TPM1 Gene Sanger sequencing, Se TPM2 Gene Sanger sequencing, Se TPM3 Gene Sanger sequencing, Se TPMT Gene Sanger sequencing, Se TPO Gene Sanger sequencing, Se TPP1 Gene Sanger sequencing, Se TRAP1 Gene Sanger sequencing, Se TRAPPC11 Gene TRAPPC2 Gene Sanger sequencing, Se TRAPPC9 Gene Sanger sequencing, Se TRDN Gene TREM2 Gene Sanger sequencing, Se TRH Gene Sanger sequencing, Se TRIM32 Gene Sanger sequencing, Se TRIOBP Gene TRIP11 Gene Sanger sequencing, Se TRMU Gene Sanger sequencing, Se TRPC6 Gene Sanger sequencing, Se TRPS1 Gene Sanger sequencing, Se TRPV4 Gene Sanger sequencing, Se TSC1 Gene Sanger sequencing, Se TSC2 Gene (A2LA Cert. No ) Revised 06/28/2018 Page 29 of 38

30 TSEN2 Gene Sanger sequencing, Se TSEN34 Gene Sanger sequencing, Se TSEN54 Gene Sanger sequencing, Se TSFM Gene Sanger sequencing, Se TSHB Gene Sanger sequencing, Se TSHR Gene Sanger sequencing, Se TSPAN12 Gene Sanger sequencing, Se TTC8 Gene Sanger sequencing, Se TTN Gene (x ) Sanger sequencing, Se TTR Gene Sanger sequencing, Se TUBA1A Gene Sanger sequencing, Se TUBB3 Gene Sanger sequencing, Se TULP1 Gene Sanger sequencing, Se TUSC3 Gene Sanger sequencing, Se TWIST1 Gene Sanger sequencing, Se TYK2 Gene TYMP Gene Sanger sequencing, Se TYR Gene Sanger sequencing, Se TYRP1 Gene Sanger sequencing, Se UBE3A Gene Sanger sequencing, Se UBIAD1 Gene Sanger sequencing, Se UBQLN2 Gene Sanger sequencing, Se UBR1 Gene UCP2 Gene Sanger sequencing, Se UGT1A1 Gene Sanger sequencing, Se UMOD Gene Sanger sequencing, Se UMPS Gene Sanger sequencing, Se UNC13D Gene UNC119 Gene UROD Gene Sanger sequencing, Se UROS Gene Sanger sequencing, Se USH1C Gene Sanger sequencing, Se USH1G Gene Sanger sequencing, Se USH2A Gene VAPB Gene Sanger sequencing, Se VCAN Gene Sanger sequencing, Se VCL Gene Sanger sequencing, Se VCP Gene Sanger sequencing, Se VHL Gene Sanger sequencing, Se VIPAS39 Gene Sanger sequencing, Se VPS13B Gene Sanger sequencing, Se VPS33B Gene Sanger sequencing, Se VPS45 Gene Sanger sequencing, Se VRK1 Gene Sanger sequencing, Se VSX1 Gene Sanger sequencing, Se VWF Gene (A2LA Cert. No ) Revised 06/28/2018 Page 30 of 38

31 WAS Gene Sanger sequencing, Se WDR35 Gene Sanger sequencing, Se WDR62 Gene Sanger sequencing, Se WDR72 Gene Sanger sequencing, Se WFS1 Gene Sanger sequencing, Se WNK1 Gene Sanger sequencing, Se WNK4 Gene Sanger sequencing, Se WNT1 Gene Sanger sequencing, Se WNT4 Gene Sanger sequencing, Se WNT10A Gene Sanger sequencing, Se WRAP53 Gene Sanger sequencing, Se WRN Gene WT1 Gene Sanger sequencing, Se WWOX Gene Sanger sequencing, Se XDH Gene Sanger sequencing, Se XIAP Gene Sanger sequencing, Se XK Gene Sanger sequencing, Se XPA Gene Sanger sequencing, Se XPC Gene Sanger sequencing, Se XPNPEP3 Gene Sanger sequencing, Se YWHAE Gene Sanger sequencing, Se ZEB2 Gene Sanger sequencing, Se ZFPM2 Gene Sanger sequencing, Se ZIC2 Gene Sanger sequencing, Se ZIC3 Gene Sanger sequencing, Se ZMPSTE24 Gene Sanger sequencing, Se ZP1 Gene Sanger sequencing, Se Achromatopsia Dystroglycan-Related Congenital Muscular Dystrophy Autosomal Dominant Limb Girdle Muscular Dystrophy Autosomal Dominant Polycystic Kidney Disease Aicardi-Goutieres Syndrome Amyothrophic Lateral Sclerosis and Frontotemporal Dementia Alzheimer s Disease, Familial, (A2LA Cert. No ) Revised 06/28/2018 Page 31 of 38

32 Ataxia with Oculomotor Apraxia Autosomal Recessive Limb Girdle Muscular Dystrophy Axenfeld-Rieger Syndrome Arrhythmogenic Right Ventricular Cardiomyopathy/Dys plasia Alport Syndrome Bardet-Biedl Syndrome Bleeding Disorder Hereditary Breast and Ovarian Cancer BRCA1/2 Brugada Syndrome, acgh Cancer Congentical Cataracts Comprehensive Cardiac Arrhythmia Congenital Central Hypoventilation Syndrome Cerebral Cavernous Malformations Congenital Dyserythropoietic Anemia Cornelia de Lange Syndrome Coagulation Factor Deficiency Congenital Fiber Type Disproportion Chronic Granulomatous Disease (A2LA Cert. No ) Revised 06/28/2018 Page 32 of 38

33 Congenital Hypothyroidism and Thyroid Hormone Resistance Congenital Hyperinsulinism Cholestasis Ciliopathy Charcot-Marie-Tooth Demyelinating Neuropathy Chromosomal Instability Syndromes Congenital Myopathy Congenital Muscular Dystrophy Congenital Myasthenic Syndrome Centronuclear Myopathy Type-VI Related Collagenopathy Colorectal Cancer, acgh Core Myopathy Chronic Pancreatitis Catecholaminergic Polymorphic Ventricular Tachycardia Craniosynostosis and Related Disorders Cone-Rod Dystrophy Distal Arthrogryposis Dilated Cardiomyopathy Distal Hereditary Motor Neuropathy (A2LA Cert. No ) Revised 06/28/2018 Page 33 of 38

34 Distal Hereditary Myopathy Distal Renal Tubular Acidosis Epilepsy: Dravet Syndrome Ehlers-Danlos Syndrome Early Infantile Epileptic Encephalopathy Early Infantile Epileptic Encephalopathy, Recessive Episodic Pain Syndrome Fanconi Anemia Facial Dysostosis Familial Atrial Fibrillation Syndrome Fetal Akinesia Deformation Sequence/Lethal Multiple Pterygium Syndrome Congenital Fibrinogen Deficiency Familial Hemophagocytic Lymphohistiocytosis Familial Hemiplegic Migraine Fraser Syndrome Generalized Epilepsy with Febrile Seizures Plus Glaucoma Glycogen Storage Disease (A2LA Cert. No ) Revised 06/28/2018 Page 34 of 38

35 Glanzmann s Thrombasthenia Hereditary Breast and Ovarian Cancer Syndrome-Expanded Hereditary Breast and Ovarian Cancer Syndrome-High Risk Hereditary Hemochromatosis Hypertrophic Cardiomyopathy Hyper IGE Syndrome Hereditary Paraganglioma- Pheochromocytoma Syndrome Hermansky-Pudlak Syndrome Hereditary Spherocytosis/Ellipto cytosis Hirschsprung Disease (Non-syndromic) Dominant and X- Linked Early Epileptic Encephalopathy Joubert and Meckel- Gruber Syndromes Kabuki Syndrome Limb Girdle Muscular Dystrophy Loeys-Dietz Syndrome Long QT Syndrome (A2LA Cert. No ) Revised 06/28/2018 Page 35 of 38

36 Left Ventricular Noncompaction Lymphedema Lynch Syndrome Marfan Syndrome and Related Aortopathies Anophthalmia/Micro phthalmia Multiple Epiphyseal Dysplasia Myofibrillar Myopathy Mitochondrial Genome Maintenance/Integrit y Nuclear Genes Malignant Hyperthermia Susceptibility Metachromatic Leukodystrophy Tuberous Sclerosis Complex Maturity Onset Diabetes of the Young Neuronal Ceroid Lipofuscinoses (Batten Disease) Nemaline Myopathy Nephronophthisis and Senior-Loken Syndrome Nonsyndromic Hearing Loss and Deafness, MLPA Optic Atrophy Oculocutaneous Albinism Ohtahara Syndrome (A2LA Cert. No ) Revised 06/28/2018 Page 36 of 38

37 Peroxisomal Disorders Pancreatic Cancer Immotile Cilia Syndrome/Primary Ciliary Dyskinesia Heterotaxy, Situs Inversus, and Kartagener s Syndrome Isolated Polycystic Liver Disease Platelet Function Disorder Periodic Fever Syndromes Autosomal Dominant and Recessive Polycystic Kidney Disease Polycystic Liver Disease Noonan Spectrum Disorders/Rasopathie s Renal Cancer Rubinstein-Taybi and Floating-Harbor Syndromes Autosomal Recessive Renal Tubular Dysgenesis Severe Congenital Neutropenia Short QT Syndrome Steroid-Resistant Nephrotic Syndrome Stickler Syndrome Stuttering (A2LA Cert. No ) Revised 06/28/2018 Page 37 of 38

38 Treacher Collins Syndrome/Mandibulo facial Dysostosis/Miller Syndrome/Acrofacial Dysostosis, Nagar Type Thrombocytopenia Usher Syndrome Vitreoretinopathy Von Willebrand Disease, Types 1,2, and 3 Warburg Micro Syndrome Waardenburg Syndrome Xeroderma Pigmentosum X-Linked Retinitis Pigmentosa (A2LA Cert. No ) Revised 06/28/2018 Page 38 of 38

39 ISO 15189:2012 Internationally-Recognized Accredited Laboratory A2LA has accredited PREVENTIONGENETICS, LLC Marshfield, WI for technical competence in the field of Clinical Testing This laboratory is accredited in accordance with the recognized International Standard ISO 15189:2012 Medical laboratories - Requirements for quality and competence. This accreditation demonstrates technical competence for a defined scope and the operation of a laboratory quality management system (refer to joint ISO-ILAC-IAF Communiqué dated January 2015). Presented this 22 nd day of April Senior Director of Quality and Communications For the Accreditation Council Certificate Number Valid to September 30, 2018 Revised June 28, 2018 For the tests or types of tests to which this accreditation applies, please refer to the laboratory s Clinical Scope of Accreditation.