Table 1 CDC Diagnostic Criteria for Chronic Fatigue Syndrome
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1 Table 1 CDC Diagnostic Criteria for Chronic Fatigue Syndrome Major Criteria New onset of fatigue causing 50% reduction in activity for at least 6 months. Exclusion of other illnesses that can cause fatigue. Minor Criteria Presence of 8 of the 11 symptoms listed or presence of 6 of the 11 symptoms and 2 of the 3 signs listed. Symptoms 1. Mild fever 2. Recurrent sore throat 3. Painful lymph nodes 4. Muscle weakness 5. Muscle pain 6. Prolonged fatigue after exercise 7. Recurrent headache 8. Migratory joint pain 9. Neurological or psychological complaints: Sensitivity to bright light Forgetfulness Confusion Inability to concentrate Excessive irritability Depression 10. Sleep disturbance (hyersomnia ro insomnia) 11. Sudden onset of symptom complex Signs 1. Low-grade fever 2. Nonexudative pharyngitis 3. Palpable or tender lymph nodes
2 Table 2 Frequency of Symptoms in CFS Symptom/Sign Frequency Fatigue 100 Low-grade fever Muscle pain Sleep disorder Impaired mental Depression Headache Allergies Sore Throat Anxiety Muscle weaknes After exercise fa PMS (women) Stiffness Visual blurring Nausea Dizziness Joint pain Dry eyes and mo Diarrhea Cough Decreased appe Night sweats 30-40
3 Table 3 Organisms Proposed as Causative Agents in CFS Epstein-Barr virus Human herpes virus-6 Inoue/Melnich virus Brucella Borrelia bugdorferi Giardia lamblia Cytomegalovirus Enterovirus Retrovirus
4 Table 4 Immunologic Abnormalities Reported for CFS Elevated levels of antibodies to viral proteins. Decreased natural killer cell activity. Low or elevated antibody levels. Increased or decreased levels of circulating immune complexes. Increased cytokin (e.g., interleukin- 2)levels. Decreased interferon levels. Altered helper/suppressor T-cell ratio.
5 Table 5 Diagnostic Criteria for Fibromyalgia Diagnosis requires fulfillment of all three major criteria and four more minor criteria: Major Criteria Generalized aches or stiffness of at least three anatomic sites for at least three months. Six or more typical, reproducible tender points. Exclusion of other disorders which can cause similar symptoms. Minor Criteria Generalized fatigue Chronic headache Sleep distrubance Neurological and psychological complaints Joint swelling Numbing or tingling sensations Irritable bowel syndrome Variation of symptoms in relation to activity, stress, and weather changes
6 Table 6 Causes of Chronic Fatigue Pre-Existing Physical Condition Diabetes Heart disease Lung disease Rheumatoid arthritis Chronic inflammation Chronic pain Cancer Liver disease Multiple sclerosis Drugs, Prescription Antihypertensives Anti-inflammatory agents Birth control pills Antihistamines Corticosteroids Tranqulizers and sedatives Depression Stress/low adrenal function Impaired liver function and/or environmental illness Impaired liver function and/or environmental illness Impaired immune function Chronic fatigue syndrome Chronic candida infection Other chronic infections Food allergies Hypothyroidism Hypoglycemia Anemia and nutritional deficiencies Sleep disturbances Cause unknown
7 Table 8 Causes of Cholestasis Dietary factors: Saturated fat Refined sugar Low fiber intake Obesity Diabetes Presence of gallstones Alcohol Endotoxins and other gut-derived bacterial toxins Herditary disorders such as Gilbert s syndrome Pregnancy Natural and synthetic steroid hormones: Anabolic steroids Estrogens Oral contraceptives Certain chemicals or drugs: Cleaning solvents Pesticides Antibiotics Diuretics Nonsteroidal anti-inflammatory drugs Thyroid hormone Viral hepatitis
8 Table 9 Factors Predisposing to Candida Overgrowth Impaired immune function Anti-ulcer drugs Broad-spectrum antibiotics Cellular immunodeficiency Corticosteroids Diabetes mellitus Excessive sugar in the diet Intravascular catheters Intravenous drug use Lack of digestive secretions Oral contraceptive agents
9 Table 10 Typcial Chronic Candidiasis Patient Profile Sex: Female Age General symptoms: Chronic fatigue Loss of energy General malaise Decreased libido Gastrointestinal symptoms: Thrush Bloating, gas Intestinal cramps Rectal itching Altered bowel function Genitourinary system complaints: Vaginal yeast infection Frequent bladder infections Endocrine system complaints: Primarily menstrual complaints: Depression Irritability Inability to concentrate Immune system complaints: Allergies Chemical sensitivities Low immune function Past history Chronic vaginal yeast infections Chronic antibiotic use for infections or acne Oral birth control use Oral steroid hormone use Associated conditions: Premenstrual symdrome Sensitivity to foods, chemicals, and other allergens Endocrine disturbances Psoriasis Irritable bowel syndrome Other: Craving for foods righ in carbohydrates or yeast
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