Facts and Myths about Wounds

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Dorcas Farmer
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1 Facts and Myths about Wounds Thomas M. Bozzuto, DO, FACEP, UHM, FFACHM, FUHM. FFAPWCAc Medical Director, Phoebe Wound Care and Hyperbaric Center, Albany, GA Past President, American College of Hyperbaric Medicine

2 Disclosure The speaker has no relevant financial interests to disclose

3 The Burden of Chronic Wounds Affect 6.5 million people Medicare spending in 2014 was $35.3 billion Infections = $16.7 billion Chronic ulcers = $9.4 billion Surgical wounds = $6.5 billion

4 Top 3

5 5-Year Mortality 100% 75% 50% 25% 0% Armstrong DG, Wrobel J, Robbins JM: Are diabetic-related wounds and Amputations worse than cancer? Int Wound Journal, 2009; 4(4): 286-7

6 Distribution of Wound Types

7 Distribution of Wound Types

8 Perspective on the Global Epidemic of Diabetes:

9 Metabolic Syndrome Diabetes Type 2

Lets talk about facts first Diabetic foot ulcers A foot ulcer is the initial event in more than 85% of major amputations that are performed on people

12 Lets talk about facts first Diabetic foot ulcers A foot ulcer is the initial event in more than 85% of major amputations that are performed on people with diabetes. In the United States, every year about 73,000 amputations of the lower limb not related to trauma are performed on people with diabetes.

13 Diabetic foot ulcers Of non-traumatic amputations in the United States, 60% are performed on people with diabetes Throughout the world, it s estimated that every 30 seconds one leg is amputated due to diabetes

14 Diabetic foot ulcers 10% of people with diabetes have a foot ulcer. The lifetime risk of developing a foot ulcer for someone with diabetes is 25%. Every year, about 1-4% of people with diabetes develop a new foot ulcer. Between 10-15% of diabetic foot ulcers do not heal Of diabetic foot ulcers that do not heal, 25% will require amputation.

Waiting to be seen by a doctor for a diabetic foot ulcer for longer than 6 weeks can increase the likelihood that the ulcer will result in an amputation.

15 Diabetic foot ulcers In one study, research showed that following an amputation, up to 50% of people with diabetes will die within 2 years. In the United States, the cost to care for diabetic foot ulcers is about $11 billion per year. Approximately 20% of hospital admissions in people with diabetes are due to foot ulcers. Waiting to be seen by a doctor for a diabetic foot ulcer for longer than 6 weeks can increase the likelihood that the ulcer will result in an amputation. The risk for amputation may be decreased by up to 75% if a team specializing in the care of diabetic foot ulcers is involved. Up to 50% of diabetic foot ulcer cases can be prevented with appropriate education focused on teaching people with diabetes how to care for their feet.

17 Efficacy of Various Treatments in Healing Diabetic Ulcers 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% TCC Apligraf Dermagraft Regranex Usual Care

18 Diabetic foot ulcers An ulcer present for more than 30 days is more likely to become infected. Osteomyelitis, is seen in 15% of people with diabetic foot ulcers. About 20% of patients with symptoms from PAD have diabetes

Smoking Smokers are 16 times more likely than non-smokers to have PAD Smokers are more likely to have amputations Smokers are more likely to have proximal amputations Higher pack-years = more likely

19 Smoking Smokers are 16 times more likely than non-smokers to have PAD Smokers are more likely to have amputations Smokers are more likely to have proximal amputations Higher pack-years = more likely to have proximal amputation Neither the amputation level nor the amputation itself was enough motivation for the patients to participate in smoking cessation. Anderson JJ, et al. A comparison of diabetic smokers and non-smokers who undergo lower extremity amputation: a retrospective review of 112 patients. Diabet Foot Ankle. 2012; 3: /dfa.v3i

20 Neuropathic Testing If the patient feels less than 7/10 points they have loss of protective sensation

21 True or False Neurontin (gabapentin) is the first line treatment for diabetic neuropathy

22 True or False Neurontin (gabapentin) is the first line treatment for diabetic neuropathy FALSE Gabapentin is NOT FDA approved for the treatment of diabetic neuropathy Which ones are? pregabalin (Lyrica) duloxetine (Cymbalta)

23 Venous and Arterial Leg Ulcers Venous Leg Ulcers Open lesion between knee and ankle that occurs in the presence of venous disease Venous disease is the MOST COMMON cause of leg ulcers (60-80%) Arterial Leg Ulcers Can occur anywhere in lower extremity Account for 5-10% of leg ulcers

Arterial Ulcers Risk factors Diabetes mellitus Foot deformity and callus formation resulting in focal areas of high pressure Poor footwear that

24 Arterial Ulcers Risk factors Diabetes mellitus Foot deformity and callus formation resulting in focal areas of high pressure Poor footwear that inadequately protects against high pressure and shear Obesity Absence of protective sensation due to peripheral neuropathy Limited joint mobility

25 Venous Leg Ulcers -Scope of the Problem Comprises 70% of LE ulcers in the U.S. 500,000-1,000,000 people Over 40% report first ulcer by age 50 13% report first ulcer by age 30 Recurrence rate 72% at one year US annual healthcare expenditure $ billion Each case > $40,000 2 million annual workdays lost

28 Venous Leg Ulcers -Scope of the Problem Most redness in VLUs are from stasis dermatitis, NOT cellulitis Antibiotics should not be given unless an ulcer is evident and infection is suspected. If an antibiotic IS prescribed, it should cover MRSA TMP-SMX doxycycline Fluoroquinolones clindamycin AVOID PCNs Cephalosporins

29 Scope of the Problem Median duration 9 months 20% have not healed in one year 66% had episodes of ulceration lasting 5 years 2-3% of total US healthcare budget

30 Treatment Underlying pathophysiology is failure of muscle pump If this is corrected, 93% of all VU s will heal at a mean of 5.3 months (requires at least 80% compliance with wear) Physical modalities Exercise Compression

31 Treatment Key Points Compression is the mainstay of therapy Always precede compression with arterial evaluation of leg mmhg is required Sustained compression is required

32 THE DEEPER THE WOUND, THE GREATER THE PAIN True or False

33 OCEAN WATER WILL HELP CLEANSE AND HEAL THE WOUND True or False

34 LET A SCAB DEVELOP OVER A WOUND, BECAUSE SCABS ARE GOOD! True or False

True or False ANTIBIOTICS SHOULD ALWAYS BE GIVEN FOR WOUNDS There is no evidence to support the routine use of antibiotics in the treatment of chronic

35 True or False ANTIBIOTICS SHOULD ALWAYS BE GIVEN FOR WOUNDS There is no evidence to support the routine use of antibiotics in the treatment of chronic wounds. 61% of chronic wound patients had received at least one antibiotic within a 6 month period Swab cultures are not effective in diagnosing wound infection

36 True or False Hydrogen peroxide is a fast way to cleanse a wound Alcohol is a sure way to disinfect a wound Betadine and peroxide help wound healing by reducing the bacteria in the wound bed. Dakin s solution is a good disinfectant Betadine Peroxide Dakin s Hypochlorous acid

37 Toxicity Index for Common Wound Cleansers Cleanser Primary Use Toxicity Index Shur Clens Wound 10 Biolex Saf Clens Cara Klens Ultra Klenz Clinical Care Uni Wash Ivory Soap Constant Clens Dermal Wound Cleanser Puri-clens Hibiclens Betadine Surgical Scrub Techni-Care Scrub Bard Skin Cleanser Hollister Skin Cleanser Wound Wound Wound Wound Wound Skin Skin Wound Wound Wound Skin Skin Skin Skin Skin 100 1,000 10, ,000

38 True or False Itching means the wound is healing. You should let a wound open to get some air. Studies have consistently proven that a moist wound environment rather than a dry one is best for wound healing.

39 True or False Frequent dressing changes with gauze dressings will reduce wound infections. Gauze dressings are an effective and cost-efficient way to promote wound healing. Wet to dry is the best.

40 Wet-to-Dry From standard to sub-standard A gauze dressing does little to impede fluid evaporation and allows for a loss of skin temperature, resulting in impaired healing Wet-to-dry is NOT selective and often removes healthy tissues Infection rates are higher Frequency required for change is not financially feasible Removing a dried dressing disperses a significant number of bacteria When the dressing dries out, the gauze becomes hypertonic drawing fluid, blood and protein that may cause a barrier at the skin surface

41 Wet-to-Dry From standard to sub-standard Gauze dressings present no physical barrier to entry of exogenous bacteria (bacteria can penetrate up to 64 layers of gauze Gauze is cheap, but the real cost of care needs to consider Labor cost of health care professional Indirect cost of ancillary supplies and services Cost of duration of care

42 Saline and Gauze Advanced Dressings Dressing change frequency Daily Three times per week Price of dressing $0.75 $10.00 Price of gloves $0.10 $0.10 Price of irrigation syringe $0.86 $0.86 Price of saline $1.12 $0.56 Price of tape $ Cost per dressing change $2.91 $11.52 Materials cost per week $20.37 $34.56 Cost of one nursing visit $ Cost of one week of visits $ $ Weekly labor costs $ $ Weekly labor cost + materials $ $ Amount of progress after 4 weeks Percent wound reduction 50% 100% Cost for 4 weeks of care $2, $1, Supply cost per 1% reduction (with patient doing self-care) $1.63 $1.38

43 Wet-to Dry Saline and gauze are essentially a one size fits all There are many advanced dressings that are specific to certain types of wounds Knowledge of advanced wound dressings is not common in health care providers Advanced dressings may be incorrectly perceived as more expensive when only considering dressing cost

44 True or False The use of a doughnut cushion can help relieve pressure and heal pressure ulcers faster Most medical supply stores unfortunately still sell doughnut-type cushions for the treatment of pressure sores. However, they have not been found to help and can often lead to worsening of the pressure sore. Experts repeatedly advise against the use of doughnuts for the prevention and/or treatment of pressure wounds.

45 Patients with venous insufficiency should keep their legs elevated as much as possible True or False

46 Action of the Musculovenous Pump in Lowering Venous Pressure in the Leg

48 Relationship between Opioid Treatment and Rate of Healing in Chronic Wounds After controlling for co-morbidities and pain score, opioid exposure was associated with delayed wound healing Opioid exposure may impact keratinocyte biology and wound healing Opioid exposure in the post-op period was associated with wound dehiscence Opioid exposure may impact ultimate wound healing and increase time to healing

49 Why? There are functionally active μ-opiate receptors on human keratinocytes. Activation of these receptors by the μ-opiate agonist β- endorphin results upregulation of TGF-β and cytokeratin 16 Shown that CK 16 response can be blocked by incubation together with the μ-opiate receptor antagonist naltrexone Biligardi PL, Sumanovski LT, Büchner S, et al. Different Expression of μ-opiate Receptor in Chronic and Acute Wounds and the Effect of β-endorphin on Transforming Growth Factor β Type II Receptor and Cytokeratin 16 Expression. J Invest Derm. 120:1, Jan

50 Non-healing stratified by opiate exposure

51 Non healing stratified by opiate dose Shanmugam VK, Couch KS, McNish S, Amdur RL. Relationship between Opioid Treatment and Rate of Healing in Chronic Wounds. Accepted Article doi:10.111/wrr

54 Advances in Skin & Wound Care March 2017

56 Questions?

Sores That Will Not Heal

Sores That Will Not Heal Introduction Some sores have trouble healing on their own. Sores that will not heal are a common problem. Open sores that will not heal are also known as wounds or skin ulcers.