Vonoprazan, aspirin and NSAIDs: new era in acid inhibition and gastroprotection

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1 1/5 This site uses cookies. More info Home / Online First Article Text Article menu Commentary Vonoprazan, aspirin and NSAIDs: new era in acid inhibition and gastroprotection Ali S Taha Correspondence to Dr Ali S Taha, Department of Medicine and Gastroenterology, University Hospital Crosshouse and University of Glasgow School of Medicine, Kilmarnock KA2 0BE, UK; ali.taha1@btinternet.com PDF The No acid, no ulcer dictum has dominated the pathogenesis and treatment of peptic ulcer disease for more than 100 years, and since it was proposed in 1910 by Dragutin (Carl) Schwarz ( ). 1 The dream of having a relatively potent and safe acid inhibitor was only realised in the mid-1970s with the marketing of cimetidine, later followed by other histamine-2 receptor antagonists (H RA). The real breakthrough only came by the late 1980s with the introduction of proton pump inhibitors (PPI). The use of these products, particularly the PPIs, continues to increase making them some of the most commonly prescribed or bought over-the-counter agents in the world. 2 4 This has added to the credibility of Schwarz s dictum, as it is exceptional to come across a peptic ulcer that does not respond fully or partially to acid inhibition. The process of healing seems to be triggered or enhanced by the presence of a relatively acid-free medium regardless of aetiological factors: Helicobacter pylori, alcohol, aspirin, nonsteroidal anti-inflammatory drugs (NSAID), or even in the case of some atypical ulcers such as those related to Crohn s disease or malignancy. 1 6 Of particular interest is the success of acid inhibitors in the healing or View Full Text 2

2 2/5 Request permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways. Request permissions Copyright information: Article author(s) (or their employer(s) unless otherwise stated in the text of the article) All rights reserved. No commercial use is permitted unless otherwise expressly granted. Linked Articles Gastroduodenal Vonoprazan prevents low-dose aspirin-associated ulcer recurrence: randomised phase 3 study Takashi Kawai Kazunori Oda Nobuo Funao Akira Nishimura Yasushi Matsumoto Yuji Mizokami Kiyoshi Ashida Kentaro Sugano Gut 2017; - Published Online First: 01 Dec doi: /gutjnl Peptic ulcer Vonoprazan prevents ulcer recurrence during long-term NSAID therapy: randomised, lansoprazolecontrolled non-inferiority and single-blind extension study Yuji Mizokami Kazunori Oda Nobuo Funao Akira Nishimura Satoshi Soen Takashi Kawai Kiyoshi Ashida Kentaro Sugano Gut 2017; - Published Online First: 07 Oct doi: /gutjnl Read the full text or download the PDF: Buy this article Subscribe

3 3/5 Log in Consultants Gastroenterologists Ipswich, Suffolk We are looking for a consultant who will support and expand the service provided by the six consultants currently in post Recruiter: Ipswich Hospital NHS Trust Consultant Physicians - General Medicine & Gastroenterology (3 Posts) Craigavon, Armagh, Banbridge & Craigavon These are full-time permanent posts based in Craigavon Area Hospital, Northern Ireland. Recruiter: Southern Health and Social Care Trust Scottish International Medical Training Fellowships Scotland The posts are designed for doctors who have completed or are close to completing training and allow you to experience working within Scotland s NHS Recruiter: NHS Education for Scotland Consultant Physician with an interest in Gastroenterology Ashford, Kent 76, ,490 We are seeking two Consultants to join the WHH team and three Consultants to join the QEQM team Other content recommended for you Non-steroidal anti-inflammatory drugs: overall risks and management. Complementary roles for COX-2 inhibitors and proton pump inhibitors. C J Hawkey et al., Gut Non-steroidal anti-inflammatory drugs and gastrointestinal damage-problems and solutions. R I Russell, Postgrad Med J Risk of upper gastrointestinal ulcer bleeding associated with selective cyclo-oxygenase-2 inhibitors, traditional non-aspirin non-steroidal anti-inflammatory drugs, aspirin and combinations. A Lanas et al., Gut Use of non-steroidal anti-inflammatory drugs and proton pump inhibitors in correlation with incidence, recurrence and death of peptic ulcer bleeding: an ecological study. Yunxia Lu et al., BMJ Open Reducing NSAID-induced gastrointestinal complications. BMJ Publishing Group Ltd, DTB

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