SCIENTIFIC PROGRAM Pharma Symposium Takeda: Changing the Game in IBD. Speakers: Bogdan Mateescu, Lucian Negreanu

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1 SCIENTIFIC PROGRAM RCCC Annual Meeting 28 th -30 th of SEPEMBER 2017 Thursday 28 th of September 2017 ECCO educational workshop Pharma Symposium Takeda: Changing the Game in IBD. Speakers: Bogdan Mateescu, Lucian Negreanu 18:45 WELLCOME COCKTAIL Friday 29 th of September Registration Opening Ceremony. Cristina Cijevschi, Mircea Diculescu Session I. IBD in Eastern Europe Epidemiological update. Chair: Cijevschi Cristina, Alina Tantau, Adrian Goldis -IBD epidemiology in Western regions of Romania. Adrian Goldis -IBD epidemiology in Eastern regions of Romania. Catalina Mihai, Cristina Cijevschi, Anca Trifan -IBD epidemiology in Central regions of Romania. Alina Tantau -Hospital-based epidemiology of IBD in Southern part of Romania. Bianca Stoica, Claudia Purice, Razvan Iacob, Mircea Diculescu. -IBD Epidemiological Trends in Eastern Europe. Svetlana Turcan, Elena Belousova, Julia Gorgun, Alina Tocan Coffee Break

2 Session II. IBD or not IBD? Significant aspects of differential diagnosis. Chair: Andrada Seiceanu, Gabriel Becheanu, Razvan Iacob. -Acute colitis: infectious colitis and drug induced colitis. Mirela Ionescu -Microscopic colitis: diagnosis and management. Irina Ciortescu -Intestinal tuberculosis: a diagnostic challenge. Razvan Iacob -Diverticulosis associated colitis and ischemic colitis vs elderly onset IBD Andrada Seiceanu Presentations structure: Histological features important for differential diagnosis - 5 min (Gabriel Becheanu and Mona Dumbrava) followed by significant clinical and paraclinical aspects (up to 15 min). 11:30-12:00. State of the Art Lecture I. Gerasimos Manzaris - Acute severe colitis 12:00-13:00. Abbvie Symposium:Keep Calm and Treat to Target. Speakers: Liana Gheorghe, Bogdan Mateescu, Adrian Goldis 13:00-14:00 Lunch break 14:00-14:30. State of the Art Lecture II. Herbert Tilg: Promising new treatment modalities in IBD.

3 Session III. Management of IBD beyond biologics: Chair. Liana Gheorghe, Anca Trifan, Lucian Negreanu - Primary non-response to biologics what to do? - Corina Pop - Loss of response to biologics what to do? - Lucian Negreanu - Nanomedicine for future IBD therapies Razvan Iacob - Modulating fecal microbiota in IBD - Gabriela Ștefănescu, Anca Trifan 15:30-16:00 Coffee break Session IV. Endoscopy in IBD : Chair : Cristian Gheorghe, Marcel Tantau, Daniela Dobru -Chromoendoscopy in IBD Alina Boeriu -Capsule endoscopy and balloon assisted enteroscopy in IBD. Ion Bancila -Postsurgical recurrence of CD. The role of endoscopy in clinical decision making. Cristian Gheorghe -Endoscopic therapy in CD. Marcel Tantau Session V. From diagnostic markers to novel therapeutic solutions in IBD. Chair : Carol Stanciu, Dan Dumitrascu, Ciprian Brisc Inflammatory markers in IBD facts and perspectives - Dan Dumitrascu Nutrition and diet in IBD. Mircea Manuc, Teodora Manuc, Maria Ciocirlan : Probiotics in IBD: hopes or illusions - Simona Grad

4 Rifaximin-α more than a simple antibiotic Mircea Diculescu. With support of Alpha Wassermann. 18:15-18:30 Pharma Symposium Vifor. Iron Deficiency in IBD Patient. Liana Gheorghe SRGH Committee Session 18:45 Dinner Restaurant Saturday 30th of September Registration Session VI. Original Research Forum. Chair : Simona Bataga, Bogdan Mateescu, Catalina Mihai Monica Cojocaru, Anca Dimitriu, Roxana Vadan, Liana Gheorghe, Bogdan Cotruta, Ion Bancila, Razvan Iacob, Cristian Gheorghe. Elderly onset IBD in a tertiary gastroenterology referral center Corina Meianu, Mihai Mircea Diculescu, Gabriel Becheanu, Mona Dumbrava, Carmen Monica Preda, Cosmin Ciora, Alexandru Lupu, Oana Stanciulea, Mugur Grasu. The density of neuroendocrine cells and the correlation with inflammatory status in intestinal mucosa of patients with inflammatory bowel disease. Theodor Voiosu, Andreea Bengus, Monica Ionita, Bogdan Mateescu. Modern therapeutic targets in IBD: deep remission in clinical practice. Results from MAID: a prospective cohort Loredana Goran, Lucian Negreanu, Bogdan Busuioc, Bogdan Mateescu. Infliximab Biosimilars therapy in IBD: real life experience from two centres

5 Anca Cardoneanu, Cristina Cijevschi. Microbiota in IBD the good the bad and the ugly Cristian Tieranu, Olivia M. Popa, Monica I. Dutescu, Mihai Bojinca, Ioana Tieranu, Mirela Ionescu, Mircea Diculescu. TNF-alpha gene polymorphisms in Romanian population with inflammatory bowel diseases Andra Consuela Ionescu, Valentina Dinca, Alina Vasilescu, Diana Zaharie- Butucel, Luciana Stanica, Simona Brajnicov, Valentina Marascu, Anca Bonciu, Laura Gaman, Mihaela Gheorghiu, Mircea Diculescu. Determination of serum lysozyme in Inflammatory bowel disease, using functional Micrococcus lysodeikticus layers deposited via layer-by-layer Pharma Symposium MSD: New perspectives for improved management of inflammatory bowel diseases: time to get IBD under continuous control. Mircea Diculescu, Dr. Mihai Ciocirlan 10: Coffee Break Session VII. Surgery in IBD : Chair: Oana Stanciulea, Dan Ionuț Gheonea, Traian Dumitrascu -Timing of surgery in IBD: Medical perspective. Elena Toader, Mihaela Dranga. -Surgical management of stricturing CD Oana Stanciulea -Managing proctological pathology in IBD Tatiana Elena Ivan, Dan Gheonea -Colectomy with ileorectal anastomosis vs colectomy with ileoanal pouch what and when to choose. Traian Dumitrascu

6 :30. Session VIII. From Pediatric to adult IBD. Chair : Daniela Serban, Alexandrina Constantinescu, Carmen Preda - Environmental factors in pediatric and adult IBD. Carmen Preda, Doina Proca, Teodora Manuc - Problems of diagnosis, evolution and therapeutic decision in pediatric Crohn's disease. Corina Cazan - Clinical and endoscopical characteristics in children and adolescents with inflammatory bowel disease treated with anti-tumor necrosis factor. Alexandrina Constantinescu - Be aware of the peculiarities of pediatric IBD patients: they are the future adults. Daniela E.Serban Pharma Symposium MSD: 5 years of anti-tnf therapy: proven benefits in long term use. Cristina Cijevschi, Liana Gheorghe Review of recent Clinical Trials in IBD. Liana Gheorghe Conclusions. Prizes Award Ceremony RCCC General Assembly. Presidential Elections :00 FAREWELL COCKTAIL

7 Poster session 1. Cristian Tieranu, Teodora Manuc, Maria Dobre, Gabriel Becheanu, Ioana Tieranu, Mircea Diculescu, Tudor Nicolaie, Mirela Ionescu. Gene expression profiles in ulcerative colitis: preliminary data comparison of endoscopically active versus inactive disease. 2. Oana Cristina Stoica, Anca Trifan, Irina Gîrleanu, Ana-Maria Singeap, Roxana Maxim, Camelia Cojocariu, Carol Stanciu. Development of a Clostridium difficile infection risk prediction score in inflammatory bowel disease patients 3. Oana Cristina Stoica, Anca Trifan, Irina Gîrleanu, Ana-Maria Singeap, Roxana Maxim, Stefan Chiriac, Camelia Cojocariu, Carol Stanciu. Frequency of extraintestinal manifestation of inflammatory bowel disease in a tertiary center from north-east Romania 4. Belei Oana, Simedrea Ioan, Olariu Laura, Marcovici Tamara, Marginean Otilia. Small-intestinal bacterial overgrowth among children with inflammatory bowel disease. 5. Bianca Stoica, Ionut Saizu, Monica Cojocaru, Anca Dimitriu, Anda Les, Antoaneta Stefan, Bogdan Cotruta, Alexandru Lupu, Speranta Iacob, Roxana Vadan, Serban Gologan, Liana Gheorghe, Cristian Gheorghe, Mircea Diculescu, Razvan Iacob. Long term follow-up of a hospital-based IBD cohort from a Romanian tertiary gastroenterology center. 6. Cristina Tocia, Anda Carmen Achim, Luana Alexandrescu, Eugen Dumitru. IBD: Focus on anemia 7. Carmen Anton. Ulcerative colitis associated with liver cirrhosis and complicated by pseudomembranous colitis particular case report. 8. Cristina-Sorina Catana, Cristian Magdas, Liviuta Budisan, Elena-Cristina Craciun, Flaviu Tabaran, Georgiana Deak, Virginia Ana Magdas, Cosmin Pestean, Ciprian Ober, Ioana Berindan- Neagoe, Vasile Cozma, Dan Lucian Dumitrascu. Trichiuris suis ova extract in experimental IBD.

8 Parallel Session SALA TRANSILVANIA Friday IBD Nurse Symposium Oportunistic infections in patients with IBD - The role of IBD nurse. Aurelia Georgescu Clostridium Difficile Infection in patients with IBD. Cristina Dumitrescu Enteral nutrition in IBD patients. Teodora Andrei The role of endoscopy nurse in managing IBD patients. Constantin Mangiru IBD nurse assistance for IBD patients with ileo-colo-stoma. Georgeta Pasarin Lunch break Coffee Break APAA Patients Forum Maria Stefanescu: Organizer / Rozalina Lapadatu: Association president