RCCC Romanian Crohn`s

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1 RCCC Romanian Crohn`s and Colitis Club 8 th National Symposium on Inflammatory Bowel Diseases 29 th of September - 1 st of October 2016 Crowne Plaza Bucharest, Romania President Mircea Diculescu Organizing scientific committee Răzvan Iacob, Dan Gheonea, Alexandru Lupu, Carmen Preda

2 Dear Guests, Friends and Colleagues, We meet again in Bucharest this year for a new National Meeting in the dynamic field of IBD. The Inflammatory Bowel Disease pathology has at least three hot spots for Romania at the beginning of the XXIst century: increasing incidence and severity, paralleled by the better knowledge for basic etiopathogenic mechanisms and novel therapeutic solutions. With the valuable help of our European friends, our National Symposium is beginning to have an International format, supporting the quality of Romania as an active member of ECCO. We will try this year, in less than three days, to start a trip through the European IBD landscape, sharing our experience with coleagues from abroad, with topics related to current diagnostic tools, as well as novel therapeutic solutions. Along dedicated conferences, symposia and courses, our Meeting will have a Young IBD Investigators Session, pediatric topics (we greet with this occasion the recently established prccc), patients dedicated events and an IBD Nurse meeting. We will definitely not be able to cover all the aspects of this complex pathology or to be able to share all the experience that we would like, but we hope that this Meeting will be able to raise at the level of your expectations and increase your knowledge with new information. Kind regards, In the name of the Organizing Commitee, Mircea Diculescu Bucharest,

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4 Romanian Crohn s and Colitis Club (RCCC) VIII th National Symposium on Inflammatory Bowel Diseases, 29 th of September - 1 st of October 2016, Crowne Plaza Bucharest, Romania Thursday 29 th of september : Registration Leading Change in IBD invited only Opening ceremony Mircea Diculescu, Dan Dumitraşcu, Liana Gheorghe Annual IBD Course. How to define clinically significant inflammation in IBD? (supported by Takeda) Chair: Cristian Gheorghe, Eugen Dumitru The role of endoscopy Cristian Gheorghe Inflamatory Bowel Disease The evolution of histological features from active disease to intestinal healing Gabriel Becheanu, Mona Dumbrava What should we know about the sectional imaging -CT and MRI- in the diagnosis of inflammatory bowel disease Ioana Lupescu Coffee break 16:15-16:30 The future starts now! - Proposal for the new electronic file to support biological treatment prescription in Romania Bogdan Mateescu Biomarkers in IBD Chair: Lucian Negreanu, Ciprian Brisc Stool biomarkers in IBD Andreea Bengus New serological markers to predict IBD outcome Carmen Preda Mucosal biomarkers in IBD Şerban Gologan, Mihai Andrei Genomic and proteomic bio-markers in IBD Roxana Zaharie 4

5 TAKEDA Symposium: IBD treatment at the crossroads Chair: Cristian Gheorghe Speakers: Anca Trifan, Liana Gheorghe Me&IBD: ASPIIR Event (patients association) Chair: Liana Gheorghe, Isabella Grosu Opening Cocktail Friday 30 th of September Travelling through Eastern Europe. From epidemiology to therapeutic particularities (I) Chair: Boris Vucelic, Mircea Diculescu, Dino Tarabar IBD Epidemiology in Moldova Svetlana Turcan Optimization of IBD Therapy Dino Tarabar From Epidemiology to Therapeutic Particularities of IBD in North-East of Romania: IBD Prospect Data Cristina Cijevschi Prelipcean, Anca Trifan, Cătălina Mihai Epidemiology of IBD and current situation with biologic therapy in Croatia Boris Vucelic Coffee break State of the Art Lecture Chair: Cristina Cijevschi Prelipcean Iron deficiency in IBD. Patients versus physicians perspectives Silvio Danese Travelling through Eastern Europe. From epidemiology to therapeutic particularities (II) Chair: Milan Lukáš, Adrian Goldiş, Tamas Molnar Epidemiology of IBD in Bucharest-Ilfov County, preliminary report of Epirom Registry Răzvan Iacob, Simona Necula, Anca Dimitriu, Monica Cojocaru and Liana Gheorghe for Epirom Study Group. Are there differences between IBD patients from Eastern and Western Europe? Adrian Goldiş 5

6 Predictors of therapeutic failure, colectomy and pouchitis in ulcerative colitis Tamas Molnar What we learned about biosimilar infliximab on therapy of IBD patients? Experience of one tertiary site in the Czech Republic Milan Lukáš ABBVIE UC Symposium - UC today: from clinical to practice Chair: Mircea Diculescu Speakers: Marc Ferrante, Anca Trifan, Bogdan Mateescu, Lucian Negreanu Lunch Ask the expert: UC approach in a changing therapeutic landscape (lunch session) Registration required by office.rccc@gmail.com. Limited number of participants; deadline for registration Chair: Liana Gheorghe Invited speaker: Marc Ferrante Supported by Abbvie Innergy Symposium: Inflammatory Bowel Disease from the perspective of intestinal dysbiosis. New evidence. Speaker: Liana Gheorghe Sofar Symposium: "Something new on the Eastern Front?" Speaker: Lucian Negreanu Review of recent clinical trials in IBD. Liana Gheorghe Gastroenterology - Rheumatology Joint Meeting Chair: Mihai Bojincă, Bogdan Mateescu Evidence of Rheumatological manifestations in IBD Anca Marineaţa, Elena Rezuş, Cristina Cijevschi Prelipcean The management of osteoarticular pathology in IBD Violeta Bojincă Paradoxical inflammation induced by anti-tnf agents in patients with IBD Corina Pop Coffee Break 6

7 Controversies in the management of IBD Chair: Cristina Cijevschi Prelipcean, Marcel Tanţău CMV reactivation in IBD diagnostic and therapeutic challenges Speranţa Iacob The use of ultrasonography in IBD Zeno Spârchez The role of endoscopic therapy in Crohn s Disease Marcel Tanţău Dysplasia in IBD: differences between theory and clinical practice Cătălin Sfarti Stem cell therapies in IBD Răzvan Iacob ABBVIE CD Symposium What is right time in CD? Clinical cases discussion Chair: Liana Gheorghe Speakers: Cristina Cijevschi Prelipcean, Eugen Dumitru, Adrian Goldiş, Alina Tanţău, Cătălina Mihai 19:00 Dinner Saturday 1 st of October Young IBD investigators selected papers and challenging IBD cases. Chair: Anca Trifan, Dan Gheonea Fistulizing Crohn s Disease - diagnostic and therapeutic challenges Alexandru Lupu, Corina Meianu How do we manage the loss of response to biological therapy? Ana Maria Singeap, Anca Trifan Is fecal calprotectin an accurate tool to assess the mucosal inflammation among children with inflammatory bowel diseases? Belei Oana, Simedrea Ioan, Olariu Laura, Marcovici Tamara, Mărginean Otilia Anemia in ulcerative colitis - clinical experience in the North-East of Romania Mihaela Dranga, Otilia Gavrilescu, Cătălina Mihai, Cristina Cijevschi Prelipcean Biological therapy in post-operatory setting of Crohn s disease (CD): a national cohort study Carmen Preda, Larisa-Elena Fulger, Liana Gheorghe, Cristian Gheorghe, Adriana Andrei, Sorin Andrei, Sandra Irina, Lucian Negreanu, Mircea Manuc, Cătălin Dutei, Mircea Diculescu 7

8 State of the Art Lecture Chair: Liana Gheorghe The Slovenian experience with Biosimilars Ivan Ferkolj 9:30-10:30 Nutrition in IBD Chair: Daniela Şerban, Mircea Manuc Why do we use enteral nutrition in pediatric Crohn s Disease? Daniela Şerban Nutrition therapy for IBD patients Roxana Vădan Vitamin D deficiency and IBD Alina Tanţău Exclusion diets in IBD Maria Ispas Coffee Break MSD Symposium: New insights and technologies to improve management and outcomes in IBD Chair: Cristina Cijevschi Prelipcean, Liana Gheorghe Speakers: Milan Lukáš, Alessandro Armuzzi State of the Art Lecture Chair: Oliviu Pascu, Adrian Goldiş Population-based study; from epidemiology to functional analyses Corinne-Gower Rousseau Antoine Cortot Honorary Member of RCCC Award Diploma - State of the Art Lecture: Impact of age on IBD: Epidemiologic approach from a population-based study IBD present and future Chair: Carol Stanciu, Alina Tanţău Severity assessment in IBD Oliviu Pascu A view from the Top: why and how to return safe and sound Bogdan Mateescu 2016: Biotherapies, biosimilars and other new assets for IBD treatment Lucian Negreanu Healing in IBD what is the meaning Alexandru Oproiu Closing Ceremony: Poster Awards Liana Gheorghe, Mircea Diculescu, Cristina Cijevschi Prelipcean 14:30 Farewell Cocktail 8

9 Friday 30 th of September IBD Nurse Symposium The role of IBD nurse in the management of IBD patient on biological therapy (Supported by MSD). Speakers: Aura Georgescu, Cornelia Ionică, Corina Gabriela Meianu Psychological aspects in IBD management the interrelation doctornurse-psychologist-ibd patient. (Supported by ASPIIR) Isabella Grosu, Ingrid Anette Hoff Melkersen Coffee break The particularities of endoscopic management in IBD, from the IBD nurse point of view. Costin Mangiru, Monica Cojocaru :00 Lunch break The role of IBD nurse in nutritional support of IBD patients (Supported by Fresenius Kabi) Teodora Andrei, Roxana Vădan Closing remarks 79

10 Poster session 1. Evidences of Extraintestinal Manifestations in Inflammatory Bowel Disease in Northeastern Romania. Anca Cardoneanu, Elena Rezus, Raluca Cezara Popa, Iolanda Popa, Irina Ungureanu, Ancuţa Didita, Otilia Gavrilescu, Mihaela Dranga, Cristina Cijevschi Prelipcean. Gastroenterology and Hepatology Institute, Iași 2. Treatment adherence and beliefs towards medication in patients with chronic immune-mediated inflammatory diseases (IMID): Romanian results from ALIGN study. Mihai Bojincă 1, Carmen M. Curea 2, Bogdan R. Mateescu 2, Carina Mihai 1, Lucian Negreanu 3, Rodica Olteanu 2, Dana L. Iosub 4, Diana Marina "Dr. Ion Cantacuzino" Clinical Hospital, Bucharest, Romania; 2. Colentina Clinical Hospital, Bucharest, Romania; 3. Emergency University Hospital Bucharest, Romania; 4. AbbVie SRL, Bucharest, Romania 3. The adverse effects of inflammatory bowel disease (IBD) treatment in a tertiary referral center. Laura Lucaciu 1, Oana Farcau 1, Paula Szanto 1, Cristina Pojoga 1, Seicean R 2, Andrada Seicean 1. 1.IRGH Prof. Dr. O. Fodor, Cluj-Napoca; 2. Regional Clinical Emergency Hospital, General Surgery, Cluj-Napoca 4. Acute generalized exanthematous pustulosis induced by anti-tnf therapy in Crohn s disease: an unusual case. Laura Lucaciu 1, Simona Senila 2, Andrada Seicean IRGH Prof. Dr. O. Fodor, Cluj-Napoca; 2. Regional Clinical Emergency Hospital, General Surgery, Cluj-Napoca 5. Favorable Clinical and endoscopic disease activity is paralleled by an increase in exposure to biologic therapy: preliminary results from a prospective IBD cohort. Andreea Bengus, Th. Voiosu, Monica Ioniţă, A. Voiosu, R.B. Mateescu. Colentina Clinical Hospital, Gastroenterology Departament 6. Time to switch in IBD. B. Busuioc, A. Bengus, M. Marinescu, C. Mocanu, R. B. Mateescu. Colentina Clinical Hospital, Gastroenterology Departament 7. Serum lysozyme in Inflammatory Bowel Disease. Andra Consuela Ionescu, Alina Vasilescu, Laura Gaman, Irina Stoian, Valeriu Atanasiu, Ionescu Lucian, Mircea Diculescu. Fundeni Clinical Institute Bucharest 8. Effect of infliximab on bone metabolism in inflammatory bowel disease patients. Ancuta Didita 2, Irina Oana Ungureanu 2, Mircea Alexandru Badea 1,2, Olivia Jigaranu 2, Cătălina Mihai 1,2, Cristina Cijevschi-Prelipcean 1,2. 1 University of Medicine and Pharmacy Grigore T. Popa Iași; 2 Institute of Gastroenterology and Hepatology, Iași 9. Biological therapy and anemia evolution in inflammatory bowel disease. Iolanda Valentina Popa 1,2, Catalina Mihai 1,2, Mihaela Dranga 1,2, Mircea Badea 1,2, Raluca Cezara Popa 2, Ancuţa Didita 2, Otilia Gavrilescu 1,2, Cristina Cijevschi-Prelipcean 1,2. 1 University of Medicine and Pharmacy "Grigore T. Popa" Iași ; 2 Institute of Gastroenterology and Hepatology, Iași 10. Vitamin D deficiency and disease activity in ulcerative colitis patients? Otilia Gavrilescu 1, Ancuța Didița 2, Raluca Cezara Popa 2, Alexandra Savin 2, Cătălina Mihai 1,2, 10

11 Cristina Cijevschi Prelipcean 1,2. 1 Grigore T. Popa University of Medicine and Pharmacy; 2 Institute of gastroenterology and hepatology, Iași 11. Biological therapy in ulcerative colitis and body mass index. Oana Irina Ungureanu 2, Anca Cardoneanu 1, Iolanda Popa 1,2, Mihaela Dranga 1,2, Cristina Cijevschi-Prelipcean 1,2 Cătălina Mihai 1,2. 1 University of Medicine and Pharmacy Grigore T. Popa Iași; 2 Institute of Gastroenterology and Hepatology, Iași 12. Is there an association between location and inflamatory status in crohn s disease? Alexandra Savin, Anca Cardoneanu, Ana-Maria Chiosa, Bogdan Cucuteanu, Cristina Cijevschi Prelipcean, Cătălina Mihai. Institute of Gastroenterology and Hepatology, Iași 13. Neutrophyl-lymphocyte ratio as a predictive marker of Crohn s disease activity. Raluca Cezara Popa, Otilia Gavrilescu, Mircea Badea, Mihaela Dranga, Cătălina Mihai, Cristina Cijevschi Prelipcean. Institute of Gastroenterology and Hepatology, Iași 14. Crohn s disease and pulmonary tuberculosis: management challenge. Roxana Maxim², Anca Trifan¹², Irina Ciortescu¹², Emanuela Sarca¹, Oana Cristina Stoica², Alina Pleșa¹², Carol Stanciu¹. 1. Institute of Gastroenterology and Hepatology Iasi, Romania; 2. University of Medicine and Pharmacy Gr.T. Popa Iaşi, România 15. Cutaneous manifestation in ulcerative colitis: diagnostic and therapeutic challenge. Oana Cristina Stoica 1, Anca Trifan 1,2, Irina Gîrleanu 1,2, Oana Tănase 2, Cătălin Alexandru Chihaia 2, Laura Statescu 1, Issa Raid 3, Carol Stanciu Gr. T. Popa University of Medicine and Pharmacy, Iași, Romania; 2. Institute of Gastroenterology and Hepatology, Iași, Romania; 3. "St Spiridon" Emergency Hospital, Department of Plastic Surgery, Iași, Romania 16. Variability of endoscopic appearance in ulcerative colitis patients hospitalized in a tertiary center from North-East Romania. Oana Stoica 1, Anca Trifan 1,2, Irina Gîrleanu 1,2, Roxana Maxim 1,Camelia Cojocariu 1,2, A.-M. Singeap 1,2, Carol Stanciu Gr. T. Popa University of Medicine and Pharmacy, Iași, Romania; 2. Institute of Gastroenterology and Hepatology, Iași, Romania 17. Pulmonary adenocarcinoma in an immunosuppressed patient with Crohn s disease. Caterina Dănilă, Lidia Ciobanu, Oliviu Pascu. Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca 18. Correlation between vitamin deficiencies and disease activity in patients diagnosed with inflammatory bowel diseases (IBD) in Western Romania. Daniela Lazăr, Adrian Goldis. Department of Gastroenterology and Hepatology, University of Medicine and Pharmacy Victor Babeș, Timișoara, Romania. 19. Incidence of latent and active tuberculosis in a Romanian cohort of BCG vaccinated, immunosuppressed patients with moderate-to-severe Crohn's disease treated with biological therapy. Preda CM, Fulger LE, Gheorghe C, Gheorghe L, Manuc M, Negreanu L, Meianu C, Dutei C, Slavulete BI, Ciora C, Diculescu MM. Fundeni Clinical Institute Bucharest. University of Medicine and Pharmacy Carol Davila, Bucharest 11

12 GENERAL INFORMATION Date and Venue Date: 29 th of September - 1 st of October 2016 Location: Crowne Plaza Bucharest, Romania Organizers Romanian Crohn`s and Colitis Club Official Language Scientific presentation will be held in Romanian language presentation slides in English CME Accreditation The Annual IBD Symposium will be credited by Romanian Medical College with Continuing Medical Education Credits 12 CMR. Certificate of Attendance Each participant will receive a Certificate of attendance, which can be picked-up from the InfoDesk, starting from October 1 st, at 13 o clock. InfoDesk The Annual IBD Symposium InfoDesk will be located in conference room lobby The working schedule will be: Thursday, September 29 th :30 18:30 Friday, September 30 th :00 19:30 Saturday, October 1 st :00 16:30 Program Handbook Each participant will receive from the InfoDesk the backpack includes program handbook and sponsors materials. Badges Participants are requested to wear their badge at all times while inside the premises. Workshop access For access in the Annual IBD Symposium InfoDesk will be located in conference room lobby room you will be using the badge which you will receive after registering at the InfoDesk. Catering Participants will serve the coffee breaks/lunch in the designated spaces, as detailed in the Program Handbook. Access to tables is based on vouchers. Mobile phone Mobile phones must be switched off during all sessions. Smoking Smoking is allowed only in designated areas. 117

13 Partner Sponsor Main Sponsors Sponsors Media Partners DATE: 29 th of September - 1 st of October 2016 LOCATION: Crowne Plaza Hotel, Bucharest, Romania ORGANIZING SOCIETIES/INSTITUTIONS: Romanian Crohn`s and Colitis Club ( RCCC ) PRESIDENT: Mircea Diculescu ORGANIZING SCIENTIFIC COMMITTEE: Răzvan Iacob, Dan Gheonea, Alexandru Lupu, Carmen Preda OFFICIAL LANGUAGE: The official language of the course is English.

PRELIMINARY SCIENTIFIC PROGRAM :50 Meet the experts- Molecular mechanisms in IBD from basic science to therapy. Franco-Romanian Meeting

PRELIMINARY SCIENTIFIC PROGRAM RCCC Annual Meeting 27th-29th of SEPEMBER 2018 Thursday 27 th of September 2018 7.30-8.00 Registration 8.00-9:50 Meet the experts- Molecular mechanisms in IBD from basic