Faecal Microbiota Transplants: The evidence and experience

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1 Faecal Microbiota Transplants: The evidence and experience Dr Simon Goldenberg Consultant Microbiologist and Infection Control Doctor Guy s & St Thomas NHS Foundation Trust

2 Gut microbiota and health Level of complexity Course of disease Responders / non-responders Influence of genetics, diet Concomitant medication C. difficile ESBL / VRE / post antibiotic dysbiosis Causality IBD and IBS Insulin resistance / type 2 diabetes / obesity Auoimmune diseases e.g. coeliac Gut-brain axis diseases e.g. autism, MS, chronic fatigue syndrome, parkinsons Adapted from: Aviv Cohen. Dig Dis Sci :5, Bakker Microbiol Spectr :4

3 The burden of CDI recurrence 20% 40% 60% After first episode After first recurrence After two or more recurrences Kelly CP, LaMont JT. N Engl J Med. 2008;359(18): ; Johnson S. International Journal of Antimicrobial Agents 33 (2009) S33-S36. Deshpande et al. ICHE :4, Age 65 years1-4, 10 Severe CDI 1,4 Previous episode of CDI 1,3-5 Co-morbidities including renal failure 1,4,6,7,10 Exposure to concomitant antibiotics4, 10 Infection with particular strains eg RT 027, RT 106 Exposure to PPIs / other gastric acid supressors 8,10 Previous hospital admission 9 1 Kyne et al. Lancet 2001; 357: Bauer et al. Clin Microbiol Infect 2009; 15: Bauer et al. Lancet 2011; 377: Hu et al. Gastro 2009; 136: McFarland et al. Am J Gastroenterol 2002; 97: Do et al. CID 1998; 26: Bauer et al. Clin Microbiol Infect 2011; 17: A1-4 8 Kwok et al. Am J Gastro 2012; 107: Eyre et al. CID 2012; 55: Deshpande et al. ICHE :4,

4 Decreased Diversity of the Faecal Microbiome in Recurrent C. difficile Patients with recurrent C.difficile have decreased phylogenetic richness Chang JY, et al. J Infect Dis 2008:197;435-8 Some bacteria remain disrupted for prolonged periods following antibiotic administration Sadowsky et al. The Fecal Bacteria, 2011 Zaura et al. mbio 6:6 Nov/Dec 2015

5 Faecal Microbiota Transplantation (FMT) Rationale: A perturbed imbalance in intestinal microbiota (dysbiosis) is associated with or causes disease and can be corrected by re-introduction of donor faeces

6 Mechanisms by which the effects of a restored microbiota prevent CDI recurrence Normal microbiota Competitive niche exclusion Direct inhibition of C. difficile growth and its toxigenic activity Modulation of metabolites bile acid transformation Trigger of immune mediated responses

7 Early History of FMT 4th century: Ge Hong described use of human faecal suspension by mouth for diarrhoea and food poisoning Zghou Hou Bei Ji Fang Handy Therapy for Emergencies 16th century: Li Shizhen prescribed fermented faeces for abdominal diseases with diarrhoea, abdominal pain, fever, vomiting and constipation; yellow dragon soup Ben Cao Gang Mu Compendium of Materia Medica

8 17 th century: veterinary medicine: Early History of FMT Transfaunation (transfer of cecal contents or fresh faeces) from healthy horses to treat horses with chronic diarrhoea Rumen transfaunation is used to refaunate cows that have been off-feed because of illness e.g mastitis Modern history: (1958) Eismann et al. 4 patients with fulminant pseudomembranous colitis treated with FMT enema

9 van Nood et al, NEJM, 2013 Study and patient characteristics Outcomes Adverse events Intervention = FMT (nasoduodenal) + vanc + bowel lavage N = 16, F:M = 8 Age(mean/median) = 73 +/- 13 Comparator = vanc N = 13, F:M = 7 Age(mean/median) = 66 +/-14 Comparator = vanc + bowel lavage N = 13, F:M = 3 Age(mean/median) = 69+/-16 Pre-FMT antibiotics = At least one course of adequate antibiotic therapy (>=10 days of Vanc >=125mg qds or >=10 days of Metronidazole 500mg tds). Total follow up period = After first infusion at 10 weeks; follow up was extended to 10 weeks after 2nd infusion Risk of bias assessment = LOW Treatment arm = FMT + vanc + bowel lavage Overall cure rate = 15/16(94%)* Cure with 1 infusion alone = 13/16 (81%)* Treatment arm = vanc Overall cure rate = 4/13 (31%)* patients at 10 weeks Treatment arm = vanc + bowel lavage Overall cure rate = 3/13 (23%)* patients at 10 weeks *P<0.01 Minor GI adverse events = 94% immediate diarrhoea, 31% abdominal pain with cramping, 19% belching - resolved within 3 hours. During follow up 3 patients had constipation (19%). Minor non-gi adverse events = Serious adverse events = Nil described Deaths = None.

10 Cammarota et al, Alimentary Pharmacol & Therap, 2015 Study and patient characteristics Outcomes Adverse events Intervention = FMT (colonoscopy) N = 20, F:M = 12:8 Age(mean/median) = 71 (range 29-89) Comparator = Vancomycin N = 19, F:M = 11:8 Age(mean/median) = 75 (range 49-93) Pre-FMT antibiotics = Vanc taper 19+/- 1 metronidazole Total follow up period = 10 weeks Risk of bias assessment = UNCERTAIN risk of bias Treatment arm = FMT Overall cure rate = 18/20 (90%)* Cure with 1 infusion alone = 13/20 (65%) Treatment arm = Vancomycin Overall cure rate = 5/19 (26%) Minor GI adverse events = 19 diarrhoea, 12 bloating (all resolved at 12 hrs) Minor non-gi adverse events = Serious adverse events = none Deaths = 2- from C.diff related complications.

11 Hota et al, Clinical Infectious Diseases, 2016 Study and patient characteristics Outcomes Adverse events Intervention = FMT (enema) N = 16, F:M = 11 Age(mean/median) = Mean 75.7 Comparator = 6 week vanc taper N = 12, F:M = 8 Age(mean/median) = Mean 69.6 Pre-FMT antibiotics = At least 1 course of vancomycin for min 10 days Total follow up period = 120 days Risk of bias assessment = UNCERTAIN risk of bias Treatment arm = FMT Overall cure rate = 7/16 (44%) Treatment arm = 6 week vanc taper Overall cure rate = 7/12 (58%) P=ns, discontinued following futility analysis Minor GI adverse events = abdominal pain, tenderness and bloating, equal in both groups Minor non-gi adverse events = Serious adverse events = 1 developed anasarca from liver disease, 1 had perf bowel from diverticulitis 35 days post FMT Deaths = None.

12 Lee et al, JAMA, 2016 Study and patient characteristics Outcomes Adverse events Intervention = Frozen FMT (enema) N = 108, F:M = 72 Age(mean/median) = Mean age 73 years Comparator = Fresh FMT (enema) N = 111, F:M = 74 Age(mean/median) = Mean age 73 years Pre-FMT antibiotics = Metronidazole and Vancomycin Total follow up period = 13 weeks Risk of bias assessment = LOW risk of bias Treatment arm = Frozen Overall cure rate = 98/109 (90.7%) Cure with 1 infusion alone = 57/108 (52.8%) Treatment arm = Fresh Overall cure rate = 95/111 (85.6%) Cure with 1 infusion alone = 56/111 (50.5%) Minor GI adverse events = Transient diarrhoea (70%), abdominal cramps (10%), nausea (5%) in 24 hours post FMT; constipation (20%) and flatulence (25%) in follow up period. No difference between the two groups Minor non-gi adverse events = Serious adverse events = 12 patients required hospitalization unrelated to FMT Deaths = 6 deaths in frozen and 13 deaths in fresh arm (unrelated to FMT).

13 Jiang et al, Alimentary Pharmacol & Therap, 2017 Study and patient characteristics Outcomes Adverse events Intervention = Fresh (colonoscopy) N = 25, F:M = 21 Age(mean/median) = Mean 75 (19-97) Comparator = Lyophilised (colonoscopy) N = 23, F:M = 13 Age(mean/median) = 63 (20-87) Comparator = Frozen (colonoscopy) N = 24, F:M = 18 Age(mean/median) = 62.5 (33-88) Pre-FMT antibiotics = Not stated Total follow up period = 2 months Risk of bias assessment = HIGH risk of bias Treatment arm = Fresh Overall cure rate = 25/25 (100%) Treatment arm = Frozen Overall cure rate = 20/24 (83%) Treatment arm = Lyophilised Overall cure rate = 18/23 (78%) Fresh vs. lyophilised P=0.022 Minor GI adverse events = no differences in the three groups. mild transient abdo pain and diarrhoea in 86% of patients. 6 experiences fatigue and 4 had a headache. 2 gained weight Minor non-gi adverse events = Serious adverse events = none Deaths = none.

14 Kao et al, Canadian J Gastroenterol & Hepatol (abstract), 2016 Study and patient characteristics Outcomes Adverse events Intervention = Overall N = 43, F:M = 30 Age(mean/median) = Not stated Comparator = Colonoscopy N = 21, F:M = 13 Age(mean/median) = Mean 67.8 Comparator = Capsule N = 22, F:M = 17 Age(mean/median) = Mean 66.3 Pre-FMT antibiotics = not reported Total follow up period = Not reported Risk of bias assessment = UNCERTAIN risk of bias Treatment arm = Overall Overall cure rate = 41/43 (95%) Treatment arm = Colonoscopy Overall cure rate = 20/22 (91%) Treatment arm = Capsule Overall cure rate = 21/21 (100%) Minor GI adverse events = Transient nausea and vomiting in 2 overall Minor non-gi adverse events = Serious adverse events = Nil Deaths = Nil.

15 Kelly et al, Annals of Internal Medicine, 2016 Study and patient characteristics Outcomes Adverse events Intervention = Donor FMT (colonoscopy) N = 22, F:M = 18 Age(mean/median) = Mean age 48 (SD 16) Comparator = Autologous FMT (colonoscopy) N = 24, F:M = 19 Age(mean/median) = Mean age 55 (SD 14) Total follow up period = 8 week outcome follow up, 6 month safety follow up Risk of bias assessment = LOW risk of bias Treatment arm = Donor FMT Overall cure rate = 20 / 22 (90.9%) Treatment arm = Autologous FMT Overall cure rate = 15/24 (62.5%) P=0.042 Minor GI adverse events = Rates of other solicited AEs (fever, abdominal pain, bloating, nausea, vomiting, diarrhea, flatulence, anorexia, and constipation) did not differ significantly between groups. Minor non-gi adverse events = Serious adverse events = None described Deaths = None.

16 Youngster et al, Clinical infectious diseases, 2014 Study and patient characteristics Outcomes Adverse events Intervention = Colonoscopy N = 10, F:M = 6 Age(mean/median) = Mean 50.4 Intervention = NG N = 10, F:M = 5 Age(mean/median) = Mean 58.6 Pre-FMT antibiotics: treatment failures of a 6- to 8-week taper with Vancomycin (95% of patients) with or without an alternative antibiotic, including Fidaxomicin (70% of participants). Total follow up period = 8 weeks follow up for primary response Risk of bias assessment = UNCERTAIN risk of bias Treatment arm = Overall Overall cure rate = 18/20 (90%) Cure with 1 infusion alone = 14/20 (70%) Treatment arm = Colonoscopy Overall cure rate = 10/10 (100%) Cure with 1 infusion alone = 8/10 (80%) Treatment arm = NG Overall cure rate = 8/10 (80%) Cure with 1 infusion alone = 6/10 (60%) P=ns Minor GI adverse events = Mild abdominal discomfort and bloating in 4 patients (20%). One child treated colonoscopically had a transient fever of 38.8 C on day 2 that resolved spontaneously Minor non-gi adverse events = Serious adverse events = 1 new diagnosis of malignancy, 1 hospitalisation for Fournier gangrene Deaths = 2 deaths (unrelated).

17 Allegretti et al, Gastroenterology (DDW abstract), 2016 Study and patient characteristics Outcomes Adverse events Intervention = Low dose FMT capsules (x30 once) N = 10, F:M = ns Age(mean/median) = ns Comparator = High dose FMT capsules (x30 daily on two consecutive days) N = 9, F:M = ns Age(mean/median) = ns Pre-FMT antibiotics = ns Total follow up period = 8 weeks Risk of bias assessment = UNCERTAIN risk of bias Treatment arm = Low dose FMT capsules (30 pills once) Overall cure rate = 7/10 (70%) Treatment arm = High dose FMT capsules ( 30 pills daily on two consecutive days) Overall cure rate = 7/9 (78%) Minor GI adverse events = none Minor non-gi adverse events = Serious adverse events = none Deaths = none.

18 Systematic review with meta-analysis: the efficacy of FMT for the treatment of recurrent and refractory CDI Single infusion Multiple infusions Author ES (95% CI) % Weight Author ES (95% CI) % Weight Case Series Aas 2003 [33] Agrawal 2016 [44] Allegretti 2014 [42] Brandt 2012 [68] Costello 2015 [69] Dutta 2014 [43] Emmanuelson 2014 [70] Ganc 2015 [34] Garborg 2010 [35] Hamilton 2012 [60] Kassam 2012 [61] Kelly 2012 [36] Kelly 2014 [30] Khan 2014 [62] Kronman 2015 [45] Lee 2014 [63] MacConnachie 2009 [64] Mattila 2012 [47] Patel 2013 [46] Pathak 2014 [65] Ray 2014 [37] Rohlke 2010 [38] Rubin 2013 [39] Satokari 2015 [40] Tauxe 2016 [66] Vigvari 2014 [72] Yoon 2010 [41] Zainah 2015 [67] Subtotal (I^2 = 76.41%, P=.00) 0.94 (0.70, 1.00) 0.83 (0.76, 0.89) 0.86 (0.65, 0.97) 0.88 (0.79, 0.95) 0.85 (0.62, 0.97) 1.00 (0.87, 1.00) 0.65 (0.43, 0.84) 0.83 (0.52, 0.98) 0.73 (0.56, 0.85) 0.86 (0.72, 0.95) 0.81 (0.62, 0.94) 0.92 (0.75, 0.99) 0.77 (0.67, 0.86) 0.90 (0.68, 0.99) 0.90 (0.55, 1.00) 0.48 (0.37, 0.58) 0.73 (0.45, 0.92) 0.90 (0.80, 0.96) 0.87 (0.69, 0.96) 0.92 (0.62, 1.00) 1.00 (0.83, 1.00) 0.95 (0.75, 1.00) 0.79 (0.68, 0.87) 0.96 (0.86, 1.00) 0.77 (0.59, 0.90) 0.90 (0.73, 0.98) 1.00 (0.74, 1.00) 0.57 (0.29, 0.82) 0.86 (0.80, 0.90) Case Series Aas 2003 [33] Agrawal 2016 [44] Allegretti 2014 [42] Brandt 2012 [68] Costello 2015 [69] Dutta 2014 [43] Emmanuelson 2014 [70] Fischer 2016 [59] Ganc 2015 [34] Garborg 2010 [35] Hamilton 2012 [60] Kassam 2012 [61] Kelly 2012 [36] Kelly 2014 [30] Khan 2014 [62] Kronman 2015 [45] Lee 2014 [63] MacConnachie 2009 [64] Mattila 2012 [47] Patel 2013 [46] Pathak 2014 [65] Ray 2014 [37] Rohlke 2010 [38] Rubin 2013 [39] Satokari 2015 [40] Tauxe 2016 [66] Vigvari 2014 [72] Yoon 2010 [41] Youngster 2014 [28] Zainah 2015 [67] Subtotal (I^2=64.82%, P=.00) 0.94 (0.70, 1.00) (0.76, 0.89) (0.65, 0.97) (0.82, 0.96) 1.00 (0.83, 1.00) (0.87, 1.00) (0.47, 0.87) (0.77, 0.85) 0.83 (0.52, 0.98) (0.67, 0.93) (0.84, 0.99) (0.76, 0.99) 0.92 (0.75, 0.99) (0.76, 0.92) (0.83, 1.00) (0.69, 1.00) (0.78, 0.92) (0.52, 0.96) (0.86, 0.98) (0.83, 1.00) (0.74, 1.00) 1.00 (0.83, 1.00) 1.00 (0.83, 1.00) 0.79 (0.68, 0.87) (0.86, 1.00) (0.70, 0.96) (0.83, 1.00) (0.74, 1.00) (0.68, 0.99) (0.49, 0.95) (0.89, 0.95) Quraishi et al, Aliment Pharmacol Ther 2017

19 Safety and efficacy of fecal microbiota transplantation for recurrent C. difficile infection from an international public stool bank: Results from a 2,050 patient multi-center cohort IDWeek healthcare facilities across 50 US states and 7 countries Clinical cure rate across all delivery modalities and CDI patient populations was 84.0% FMT by colonoscopy (85.8% clinical cure, n=1441) was superior to upper endoscopy (74.1% clinical cure, n=201) (p<0.01). 42 AEs were reported; however, no AEs were determined to be definitely related to FMT, 3 were possibly related to FMT and 39 not related

20 Treatment of 3 CDI recurrences If there is a third recurrence after a pulsed vancomycin regimen, FMT should be considered (Conditional recommendation, moderate quality evidence) Am J Gastroenterol Apr;108(4):478-98; For multiple recurrent CDI unresponsive to repeated antibiotic treatment, faecal transplantation in combination with oral antibiotic treatment is strongly recommended (A-I). Clin Microbiol Infect 2014; 20 (Suppl. 2): 1 26

21 Consider donor stool transplant in cases of recurrent CDI This procedure should only be considered for patients with recurrent C. difficile infections that have failed to respond to antibiotics and other treatments.

22 Survey of practice of FMT for CDI in the UK, 2015 N=255: 120 Microbiology / ID 84 Gastroenterology Responding sites England Scotland Wales Total sites responding Sites that performed FMT FMT >1 year FMT <1 year FMT >10 patients FMT<10 patients Quereshi et al. National survey of practice of faecal microbiota transplantation for Clostridium difficile infection in the UK. J Hosp Infect 2016

23 Summary n Success rate of ~90% when FMT is used to treat recurrent CDI n FMT is an appropriate salvage therapy for multiply recurrent CDI n Currently 9 RCTs reported in the literature plus many case series with 1000 s of patients n Lower GI administration appears to be more effective, however is more invasive and costly n Frozen FMT is as effective as fresh, capsulised product also appears to be effective and may become standard route of administration n Significant differences in methods and protocols with lack of standardization Joint HIS/BSG guidelines about to go out for consultation

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