Pharmacotherapy Handbook
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1 Pharmacotherapy Handbook Eighth Edition Barbara G. Wells, PharmD, HP, FCCP, BCPP Dean and Professor Executive Director, Research Institute of Pharmaceutical Sciences School of Pharmacy, The University of Mississippi Oxford, Mississippi Joseph T. DiPiro, PharmD, FCCP Professor and Executive Dean South Carolina College of Pharmacy Medical University of South Carolina, Charleston, and University of South Carolina, Columbia Terry L. Schwinghammer, PharmD, FCCP, FASHP, FAPhA, BCPS Professor and Chair, Department of Clinical Pharmacy School of Pharmacy, West Virginia University Morgantown, West Virginia Cecily V. DiPiro, PharmD Consultant Pharmacist Mount Pleasant, South Carolina Medical New York Chicago San Francisco Lisbon London Madrid Mexico City Milan New Delhi Paris San Juan Seoul Singapore Sydney Toronto
2 Preface Acknowledgments To the Reader ix x xi BONE AND JOINT DISORDERS Gout and Hyperuricemia 1 2. Osteoarthritis 9 3. Osteoporosis Rheumatoid Arthritis 33 2: CARDIOVASCULAR DISORDERS 5. Acute Coronary Syndromes Arrhythmias Cardiac Arrest Dyslipidemia Heart Failure 99 Hypertension Ischemic Heart Disease Shock 149 Stroke 162 Venous Thromboembolism 169 3: DERMATOLOCIC DISORDERS Acne Vulgaris 185 Dermatologic Drug Reactions and Common Skin Conditions 192 Psoriasis 199 4: ENDOCRINOLOGIC DISORDERS Adrenal Gland Disorders Diabetes Mellitus Thyroid Disorders 237
3 Contents 5: GASTROINTESTINAL DISORDERS Edited by Joseph T. DiPiro and Terry L. Schwinghammer Cirrhosis and Portal Hypertension Constipation Diarrhea Gastroesophageal Reflux Disease Hepatitis, Viral Inflammatory Bowel Disease Nausea and Vomiting Pancreatitis Peptic Ulcer Disease 329 6: GYNECOLOGIC AND OBSTETRIC DISORDERS 30. Contraception 31. Menopause & & Postmenopausal Hormone Therapy Pregnancy and Lactation: Therapeutic Considerations 7: HEMATOLOGIC DISORDERS 33. Anemias 34. Sickle Cell Disease 8: INFECTIOUS DISEASES Edited by Joseph T. DiPiro 35. Antimicrobial Regimen Selection Central Nervous System Infections Endocarditis 423 Fungal Infections, Invasive 39. Gastrointestinal Infections 40. Human Immunodeficiency Virus Infection 41. Influenza. 488 Intraabdominal Infections 43. Respiratory Tract Infections, Lower 44. Respiratory Tract Infections, Upper 45. Sepsis and Septic Shock
4 Contents 46. Sexually Transmitted Diseases Skin and Soft-Tissue Infections Surgical Prophylaxis Tuberculosis Urinary Tract Infections and Prostatitis 599 Vaccines, Toxoids, and Other Immunobiologics 613 9: NEUROLOGIC DISORDERS 52. Alzheimer's Disease Epilepsy Headache: Migraine and Tension-Type Pain Management Parkinson's Disease Status Epilepticus 715 NUTRITIONAL DISORDERS 58. Assessment of Nutrition Status and Nutrition Requirements Enteral Nutrition Obesity 745 Parenteral Nutrition : ONCOLOGIC DISORDERS 62. Breast Cancer Colorectal Cancer Lung Cancer Lymphomas Prostate Cancer Renal Cell Carcinoma 811 OPHTHALMIC DISORDERS 68. Glaucoma 819
5 PSYCHIATRIC DISORDERS 69. Anxiety Disorders Bipolar Disorder 851 Major Depressive Disorder Schizophrenia Sleep Disorders Substance-Related Disorders : RENAL DISORDERS 75. Acid-Base Disorders Acute Kidney Injury Chronic Kidney Disease Drug Therapy Individualization for Patients with Chronic Kidney Disease Electrolyte Homeostasis 983 RESPIRATORY DISORDERS 80. Allergic Rhinitis Asthma 82. Chronic Obstructive Pulmonary Disease 1030 UROLOGIC DISORDERS 83. Benign Prostatic Hyperplasia 84. Erectile Dysfunction 85. Urinary Incontinence APPENDICES Appendix Allergic and Drug Reactions Appendix 2. Geriatrics 1072 Appendix 3. Drug-Induced Hematologic Disorders 1077 Appendix 4. Drug-Induced Liver Disease 1082 Appendix 5. Drug-Induced Pulmonary Disease 1085 Appendix 6. Drug-Induced Kidney Disease 1092 VIII 1097 \
Barbara G. Wells, PharmD, FASHP, FCCP, BCPP Dean and Professor School of Pharmacy, The University of Mississippi Oxford, Mississippi
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