Driving access to medicine
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1 Driving access to medicine An example from the Novartis Malaria Initiative Hans Rietveld Director, Market Access & Capacity Building Novartis Malaria Initiative Social Forum - Geneva February 20, 2015
2 Efforts by Global Health Community to control and eliminate malaria continue to yield positive results Progress made % decrease in mortality rate in Africa 26% decline in incidence globally 4.3 million malaria deaths averted globally BUT Every 60s 60 seconds ONE child in Africa dies of malaria *Source: WHO, World Malaria Report 2014
3 Malaria Initiative Mission and Strategy Remain the Pharmaceutical leader in efforts contributing to Malaria Elimination Provide Treatment Ensure Access Build Capacity R&D for novel antimalarials INNOVATION & PARTNERSHIP
4 72 Million treatments delivered in 2014 >700 Million treatments delivered without profit since to 65 malaria endemic countries
5 Responding to the unmet medical needs of infants & children > 250 Million pediatric formulations delivered! NIGERIA First child-friendly ACT introduced in 2009 Public-private partnership with Medicines for Malaria Venture (MMV) Meeting the calls from UNICEF and WHO to make medicines child-sized Helping to reduce child mortality
6 Improving patient compliance with Coartem 80/480, a new treatment with lower pill burden for adult patients Full adult treatment course reduced from 24 tablets to 6 tablets Launch ongoing in malaria endemic countries in Sub- Saharan African 6
7 Power of One One dollar donated. One child treated Ground-breaking collaboration between Novartis and Malaria No More* Public fundraising campaign to fund malaria tests and treatments through online and mobile technology One dollar donated. One child treated Novartis matches up to 1 million treatments every year for 3 years Achieved 3 million treatments for Zambia and closed the malaria treatment gap Campaign on-going: *US-based charity
8 From SMS for Life 1.0 to SMS for Life 2.0 From mobile phone to TABLET Partnering with Lagos State Ministry of Health, Nigeria A new tablet computer-based SMS for Life solution to support: Medical stock visibility and reporting Disease surveillance Health worker training
9 Capacity building Training, education, and awareness Best Practice Sharing Workshops Provide forum for best practice sharing among National Malaria Control Program managers and key partners Health Systems Strengthening Develop innovative tools to improve health workers knowledge of malaria case management Pharmacist Academy to train pharmacists on malaria case management piloted in Kenya and Nigeria Public Awareness Provide educational materials for school children
10 Accelerating malaria elimination New drugs with following key properties are needed: 1. Novel mechanisms of action to anticipate emergence of artemisinin resistance 2. Single dose treatment to improve patient compliance and target asymptomatic patients 3. Drug that kill gametocytes and prevent parasite transmission 4. Drugs with prophylactic activity 5. P. vivax radical cure to prevent disease relapse 6. Drugs for special populations (pregnant women; G6PD deficiency)
11 Novartis has a strong pipeline of next generation antimalarial drugs Artemisinin Resistance KAE609 (spiroindolone, Ph II) KAF156 (Imidazolopiperazine, Ph II) Single Exposure KAE609 KAF156 Radical Cure PI4K (Imidazopyrazines, Pre-clin) Prophylaxis KAF156 Transmission Blocking Potential KAE609 KAF156 11
12 Extensive partnership and collaboration driving industryleading progress in drug discovery for malaria treatment NITD in partnership with academic centers, MMV, BPRC, WT, and others Accelerated drug discovery: High throughput screening to clinical Proof-of-Concept in less than 6 years for both KAE609 and KAF156 Novartis Institute for Tropical Diseases (NITD); Medicines for Malaria Venture (MMV); Biomedical Primate Research Centre (BPRC); Wellcome Trust (WT); Kenyan Medical Research Institute (KEMRI) 12
13 ...Key Challenges Adequate funding Potential spread of artemisinin resistance Accelerating development of new drugs Malaria diagnostics access for all patients Counterfeits & sub-standard antimalarials Making access more sustainable 13
14 Pioneering new approaches Arogya Parivar (Healthy Family) in India, started in 2007, break-even after 30 months Increasing access to products Broad portfolio: Ca. 100 drugs included Selected based on local disease burden (incl. EMLs) Ensuring affordability: Low-cost generics, vaccines, OTC and Pharma products Customized packs for local needs and labeling in local dialect Providing education and services Health education: Local health educators present on prevention, child and maternal health and symptom awareness Healthcare Professional education: Address limited training Supply management: Ensure continuity of supply in village pharmacies Provided directly in villages via health camps Making an impact Improved access to healthcare across 10 states, in ca. 30,000 villages, home to 50 million people Partnering with thousands of clinics and pharmacies More than 300,000 village health meetings and health camps conducted, attended by almost 11 million people ( ) Conversion rate 12% (vs 2% at the outset of the program) Break-even after 30 months 14
15 Group Social Business is now operating in new countries India Since 2007 Kenya Since Mar 2012 Vietnam Since Nov 2012 Indonesia In rollout stage KPIs 2014 FTEs 529 People reached 6.6 million Patients reached 788,000 15
16 ...NO ONE should die of malaria today 16
17 This presentation was part of the Roundtable on Good practices in promoting access to medicines during the Social Forum on 20 th February, 2015 in Geneva. Please note that the views and opinions of the speakers do not necessarily reflect those of Novartis. Novartis only recommends the use of its products in accordance with the locally approved package insert. GLEM/COARTEM/0003
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