Probiotics : What we Know and Where we are Going Next

Size: px
Start display at page:

Download "Probiotics : What we Know and Where we are Going Next"

Transcription

1 Probiotics : What we Know and Where we are Going Next Neerja Hajela, Ph.D. General Manager - Science and Regulatory Affairs Yakult Danone India Pvt. Ltd.

2 Functional Food Market Probiotics an important category Global functional foods market revenue by product, 2015 & 2024 (USD Billion) Functional Foods Market Analysis By Product (Carotenoids, Dietary Fibers, Fatty Acids, Minerals, Prebiotics & Probiotics, Vitamins), By Application, By End-Use (Sports Nutrition, Weight Management, Immunity, Digestive Health) And Segment Forecasts, 2014 To 2024: Market research Report

3 Expected Probiotic Market Growth ( ) Asia-pacific ranks as the fastest growing market, Japan, Europe and the United States represents major market worldwide. Industry participants majorly include Chr. Hansen Holding A/S, Yakult Honsha Co., Ltd., Danone, Nestle, Probi AB, Danisco A/S, Lallemand Inc., and Arla Foods, Inc. Probiotics Market Analysis and Reports UK Conference Series 2017

4 Intestinal Health the reason for Probiotics

5 The Intestine what we did not know.. Digestion of food and absorption of nutrients 2 nd Brain of the Human body- 100 million neurons and 2/3 rd of the body s neurotransmitters Largest immune organ 70 % of the immune cells are present here 100 trillion microbes outnumber the human cells by a factor of 10 intestinal microbiota

6 The intestinal microbiota the forgotten organ O Hara A.M. et al. EMBO reports 2006; 7:

7 Dysbiosis of the intestinal microbiota link to disease?

8 Microbes in the Gut

9 Gut Dysbiosis

10 Interventions for modulation of the intestinal microbiota

11 Favorable modification of the gut flora Probiotics Live microorganisms which when administered in adequate amounts confer a health benefit on the host. FAO/WHO (2001) Prebiotics Prebiotics are non-digestible substances that when consumed provide a beneficial physiological effect on the host by selectively stimulating the favourable growth or activity of a limited number of indigenous bacteria. Gibson GR & Roberfroid MB (1995) Synbiotics Probiotic + prebiotic (synergy?)

12 Definition in 2001 Live micro-organisms which, when administered in adequate amounts, confer a health benefit on the host

13 Probiotic Guidelines - The Start Guidelines for the Evaluation of probiotics in Food. Report of a Joint FAO/WHO Working Group on Drafting Guidelines for the Evaluation of probiotics in Food. London Ontario, Canada. April 30 and May 1, Joint Food and Agriculture Organization/World Health Organization: Guidelines for the evaluation of probiotics in foods. London, Ontario, Canada; 2002, 1-11.

14 Definition in 2014 live microorganisms that, when administered in adequate amounts, confer a health benefit on the host Hill C et al (2014) Nat Rev Gastroenterol Hepatol 11:

15 Framework for Probiotic Products Probiotic Live cultures Probiotic drugs Probiotic medical foods Probiotic foods Non-oral probiotics Probiotic animal feed Defined microbial consortia Probiotic dietary supplement Probiotic infant formula Fermented foods with undefined microbial content Not probiotic Undefined consortia, including faecal microbiota transplant Hill C et al (2014) Nat Rev Gastroenterol Hepatol 11:

16 Changing Perception Low dose food supplement Inactive Eg. Yoghurts Old generation Not scientifically backed Doubtful efficacy Eg. Yeast NO FIT New generation Scientifically tested Efficacy demonstrated Clear proof of concept FIT WHO DEFINITION OF PROBIOTICS Inadequate amounts Health benefit not demonstrated Live microorganisms which when administered in adequate amounts, confer a health benefit on the host.

17 Probiotic - Characterization and Benefits

18 What makes a Probiotic? Stable and well-described organism, Nontoxic, Non-pathogenic, Generally Recognized As Safe (GRAS) Resistant to Gastric juices, Bile and Pancreatic juices Able to transit the Gastro-intestinal Tract and transiently colonize the target site small intestine/ large intestine Impart a scientifically proven health benefit.

19 Probiotic Organisms

20 Probiotic Characterization 1. Genus, Species and Strain identification - Phenotypic and Genotypic tests validated standard methodology 2. In vitro tests to screen potential probiotic strains - Resistance to gastric acid, bile and pancreatic juice - Antimicrobial activity - Bile salt hydrolase activity - Ability to reduce pathogen adhesion 3. In vivo safety studies in animals - Subsequent testing in animal (rats and mice) models Assessment of acute, sub acute and chronic toxicity - Not necessary for strains with documented established use

21 4. In vivo efficacy studies in animals Validated animal models to be used prior to human trials 5. Evaluation of safety of the probiotic for human use - Generally Recognized as Safe - Antibiotic Resistance patterns - Toxin production or hemolytic activity - Immune compromised individuals 6. Evaluation of efficacy in humans Clinically significant improvement in condition, reduced risk of disease, or longer time to next occurrence, faster recovery from illness. 7. Probiotic benefits - Acute Gastroenteritis, Irritable Bowel Syndrome, Necrotizing Enterocolitis. - Probiotic benefits in other aspects of health functionality obesity and metabolic disorders, prevention of cancers, cognitive and mood enhancing benefits.

22 Study - Meta analysis; 84 trials ; n patients Eight different Gastrointestinal disorders Infectious diarrhoea, Pouchitis, AAD, Traveler's diarrhoea, IBS, C diff infection, NEC. Conclusion: Probiotics are generally beneficial in treatment and prevention of gastrointestinal diseases.

23 Study : Cochrane review, 63 studies, n subjects Conclusion: Probiotics appear to be safe and shortened duration of diarrhoea and reduced stool frequency in acute infectious diarrhoea. Allen SJ et al (2010) Cochrane Database of Systematic Reviews 11:CD

24

25

26 An Indian study

27

28 Schematic Diagram Probiotic Group 1894 children 7/12/07 10/13/07 1/5/08 Probiotic drink (65 ml/ day) Follow up 12week 12week 3758 children (1 to 5 years) Double-blind Controlled Trial Nutrient Group 1864 children Determine & Compare incidence, duration, outcome, and pathogens of acute diarrhoea 12week 12week Nutrient (65 ml/ day) Follow up Nutritional assessment (height, weight and mid-arm circumference) will be done at the, and (beginning, after 12weeks, and at the end of follow-up)

29

30 Benefit of the probiotic Occurrence of diarrhoea & protective efficacy of the probiotic Variable Children with diarrhoea Incidence of diarrhoea no. of cases /child / year Probiotic (n=1802) Nutrient (n=1783) Protective efficacy of probiotic (95% CI)* Simple analysis # Percent (4-23) Probiotic - Protective efficacy 14% (95% CI: 4%,23%)

31 Recommendations European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Probiotics in the management of acute gastroenteritis in children Probiotics for children with mild Ulcerative Colitis when standard therapy isn t working. European Society of Primary Care Medicine Probiotics in management of lower gastrointestinal symptoms in clinical practice. World Gastroenterology Organization Probiotics for different gastrointestinal indications - for adults and children. World Allergy Organization Likely benefit from probiotic use in pregnant women who are at risk of having an allergic child or in infants at high risk of developing allergy.

32 Quantities Probiotic benefits are strain specific No general minimal level for the probiotic count Bifidobacterium infantis was effective in alleviating symptoms of IBS at 100 million cfu/ day, whereas studies with VSL#3 have used sachets with billion cfu/day.

33 Carrier matrix and probiotic products

34 Dairy The Preferred Medium Low ph of the product Buffers stomach acidity - ensures viability of the probiotic bacteria. Short shelf life or refrigeration - Probiotic survival in product. Nutrition and optimal expression of probiotic functionality Compliance - Food vs. Pill. Dairy based probiotic foods represent the largest segment accounting for nearly 65% of the total probiotic food market.

35 Fermented Dairy Matrices for Probiotics Fermented Dairy Products Fermented Dairy Probiotics Along with Starter Fermented with the probiotic only Yoghurt Curd Cheese Fermented Milk Drinks

36 Probiotic Foods in Indian Market Lactobacillus acidophillus and Bifidobacterium lactis Lactobacillus acidophilus Lactobacillus casei strain Shirota LA5 Bifidobacterium bifidus, Streptococcus thermophillus, Lactobacillus bulgaricus and Lactobacillus acidophillus strains ( Min 10 7 Bacteria /ml. BB 12

37 Manufacturing Process Probiotic Strain Influenced by Industrial processing as well as the food matrix Small changes in properties may significantly alter in vivo functionality Adequate Quality Assurance and Good Manufacturing Practices - Safety and Efficacy CODEX General Principles of Food Hygiene and Guidelines for application of Hazard Analysis and Critical Control Point (HACCP) should be followed.

38 Probiotic Product Safety Stability Survival Efficacy

39 Probiotic Guidelines and Regulations

40 Probiotic categorization across the Globe

41

42

43

44 Guidelines for evaluation of candidate probiotic strains Strain Identification by Phenotypic and Genotypic Methods Genus, Species and Strain Deposit strain in an Internationally Recognized collection Screening of Potential Probiotic Strains In vitro Tests In vivo studies in validated animal models for : Safety Efficacy In vivo studies in humans for clinical evaluations Phase 1 (Safety) Phase 2 (Efficacy) Phase 3 (Effectiveness)* PROBIOTIC FOODS Labeling Requirements Genus, Species, Strain Minimum viable numbers of Probiotics at the level at which efficacy is claimed and at the end of shelf-life Health claim (s) Serving size for efficacy Storage conditions

45 MINISTRY OF HEALTH AND FAMILY WELFARE (FOOD SAFETY AND STANDARDS AUTHORITY OF INDIA) NOTIFICATION New Delhi, the 23rd December, 2016 Gazette Notification of Food Safety and Standards (Food or Health Supplements, Nutraceuticals, Foods for Special Dietary Uses, Foods for Special Medical Purpose, Functional Foods and Novel Food) Regulations, 2016 (Uploaded on: ).

46

47

48

49 Labelling for Probiotic Foods (iii) Every package of probiotic food shall carry the following information on the label, namely:- a) the words PROBIOTIC FOOD ; b) Genus and species including strain designation or culture collection number, where applicable, in brackets where probiotics are mentioned in the list of ingredients; c) Viable numbers at the end of the shelf-life of probiotic strain corresponding to the level at which the efficacy is claimed; d) the recommended serving size which shall deliver the effective viable dose of probiotics related to health claims and recommended duration of use, proper storage temperature conditions, and time limit for Best Use after opening the container; e) an advisory warning NOT FOR MEDICINAL USE prominently written; and f) a warning or any other precaution to be taken while consuming, known side effects, if any, contraindications, and product-drug interactions, as applicable.

50

51

52 Why probiotics? Cost savings from patients who do not acquire an infection or recover more quickly driving forces in making probiotics a part of the health care system. Use of probiotics to prevent and treat respiratory tract infections saving of $100 million /year (Canada and France). We live in a microbial world its time to design how we live around the microbes rather than only respond when the wrong ones attack us.

53 We are them & They are us

54

NEERJA HAJELA, PhD Head Science Yakult Danone India Pvt. Ltd.

NEERJA HAJELA, PhD Head Science Yakult Danone India Pvt. Ltd. NEERJA HAJELA, PhD Head Science Yakult Danone India Pvt. Ltd. What we already know. Functional Foods - foods that provide a health benefit beyond the traditional nutrients it contains.. American Dietetics

More information

Probiotics Market Size, Share, Analysis, Growth, Trends, Outlook and Forecasts to 2024 Hexa Research

Probiotics Market Size, Share, Analysis, Growth, Trends, Outlook and Forecasts to 2024 Hexa Research Probiotics Market Size, Share, Analysis, Growth, Trends, Outlook and Forecasts to Hexa Research The global probiotics market size was valued at USD 38.32 billion in 2016. Increasing prevalence of Irritable

More information

Fonterra Probiotics: From guts to glory

Fonterra Probiotics: From guts to glory Fonterra Probiotics: From guts to glory James Dekker April 16, 2015 Host Institution Probiotic bacteria Live micro-organisms which, when administered in adequate amounts, confer a health benefit on the

More information

The role of nutrition in optimum gastrointestinal health

The role of nutrition in optimum gastrointestinal health The role of nutrition in optimum gastrointestinal health Kelly A. Tappenden, Ph.D., R.D., FASPEN Kraft Foods Human Nutrition Endowed Professor University Distinguished Teacher-Scholar University of Illinois

More information

Next generation of probiotics

Next generation of probiotics Session: Evaluating next generation ingredients to support digestive health Wednesday 23 rd November 2016 Next generation of probiotics Louise R Wilson RD PhD Assistant Science Manager, Yakult UK Ltd LWilson@yakult.co.uk

More information

Probiotics for Disease Prevention and Amelioration. Neerja Hajela, PhD Yakult Danone India Pvt. Ltd.

Probiotics for Disease Prevention and Amelioration. Neerja Hajela, PhD Yakult Danone India Pvt. Ltd. Probiotics for Disease Prevention and Amelioration Neerja Hajela, PhD Yakult Danone India Pvt. Ltd. Microbiology turns inwards Human Metagenome project and Meta Hit project reveals that the gut micro flora

More information

Manipulating the gut microbiome

Manipulating the gut microbiome Manipulating the gut microbiome William DePaolo, PhD Associate Professor Medicine Director Center for Microbiome Sciences & Therapeutics University of Washington Microbiota The actual bugs that reside

More information

PROBIOTICS: WHO S WHO AND WHAT S WHAT IN THE GUT PROBIOTICS: WHAT ARE THEY, AND HOW DO THEY WORK? Karen Jensen, (Retired ND)

PROBIOTICS: WHO S WHO AND WHAT S WHAT IN THE GUT PROBIOTICS: WHAT ARE THEY, AND HOW DO THEY WORK? Karen Jensen, (Retired ND) PROBIOTICS: WHO S WHO AND WHAT S WHAT IN THE GUT Karen Jensen, (Retired ND) Today many people are aware of the benefits of maintaining a healthy gut. As a result, probiotic use is becoming ever more popular.

More information

Probiotic yoghurt and supplements: Retail sales in the EU Supplements and yoghurts to record 4%, and -1% growth over

Probiotic yoghurt and supplements: Retail sales in the EU Supplements and yoghurts to record 4%, and -1% growth over Probiotic yoghurt and supplements: Retail sales in the EU Supplements and yoghurts to record 4%, and -1% growth over 217-218 1 Probiotic yoghurt and supplements in the EU, retail sales, 29-218 7 1% 6 8%

More information

Understanding probiotics and health

Understanding probiotics and health Understanding probiotics and health Gemma Laws MSc Student Microbiology and Immunology Department The gut microbiota The name given to the total microbial population living in our intestine Bacteria, fungi,

More information

Probiotics. Wide spectrum of important health benefits

Probiotics. Wide spectrum of important health benefits Probiotics Part 1: What Are Probiotics? Probiotics are live microorganisms that inhabit the respiratory and gastrointestinal tracts and the skin. They are often referred to as friendly bacteria as they

More information

Understanding Today s Probiotics Regulations in South East Asia. Wai Mun Poon Regulatory Affairs Consultant

Understanding Today s Probiotics Regulations in South East Asia. Wai Mun Poon Regulatory Affairs Consultant Understanding Today s Probiotics Regulations in South East Asia Wai Mun Poon Regulatory Affairs Consultant waimun@wongsjasia.com Probiotic Foods in South East Asia More probiotic foods are being introduced

More information

Examining the effects of pre and probiotics on gut microbiota during the ageing process

Examining the effects of pre and probiotics on gut microbiota during the ageing process Session: Reviewing key ingredients shaping nutrition for healthy ageing Tuesday 22 nd November 2016 Examining the effects of pre and probiotics on gut microbiota during the ageing process Louise R Wilson

More information

THE MARKET FOR PRE- AND PROBIOTIC INGREDIENTS

THE MARKET FOR PRE- AND PROBIOTIC INGREDIENTS «1» THE MARKET FOR PRE- AND PROBIOTIC INGREDIENTS (Excerpts from the full paper delivered at the IFT Short Course in June 2002) Introduction This paper is based on several market studies carried out by

More information

9/18/2018. The Physiological Roles of the Intestinal Microbiota. Learning Objectives

9/18/2018. The Physiological Roles of the Intestinal Microbiota. Learning Objectives The Physiological Roles of the Intestinal Microbiota Kelly A. Tappenden, Ph.D., R.D., FASPEN Professor and Head, Kinesiology and Nutrition University Distinguished Teacher-Scholar University of Illinois

More information

PROBIOTICS. what they are and what they can do for you. A patient s guide from your doctor and

PROBIOTICS. what they are and what they can do for you. A patient s guide from your doctor and PROBIOTICS what they are and what they can do for you A patient s guide from your doctor and Probiotics Products containing probiotics have flooded the market in recent years. As more people seek natural

More information

SUPER PROBIO OR... 1 capsule! 20 BILLION. 40 pots WORLDWIDE BACTERIA PER CAPSULE PRACTITIONER STRENGTH

SUPER PROBIO OR... 1 capsule! 20 BILLION. 40 pots WORLDWIDE BACTERIA PER CAPSULE PRACTITIONER STRENGTH WORLDWIDE HEALTH CENTER Natural Health Products & Remedies Important note: This product fact sheet is for professional use and contains guideline information only. A direct copy of the information contained

More information

Lavanya Nutankalva,MD Consultant: Infectious Diseases

Lavanya Nutankalva,MD Consultant: Infectious Diseases Lavanya Nutankalva,MD Consultant: Infectious Diseases Introduction The word Probiotic was derived from the Greek phrase meaning for life." was first coined in the 1960s by Lilly and Stillwell. Probiotics

More information

What Are Probiotics? PROBIOTICS

What Are Probiotics? PROBIOTICS PROBIOTICS What Are Probiotics? Probiotics are living, microscopic (very small) organisms that can help your gut health. Most often, probiotics are bacteria, but they may also be other organisms, such

More information

Clinical Report: Probiotics and Prebiotics in Pediatrics

Clinical Report: Probiotics and Prebiotics in Pediatrics www.medscape.com Authors and Disclosures Author(s) Dan W. Thomas, MD Professor of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California; Head, Division of Gastroenterology

More information

Q What are Probiotics?

Q What are Probiotics? Q What are Probiotics? The word PROBIOTIC was originated from Latin and means For Life. Probiotics are good bacteria usually found in food products or supplements which play very important roles in regulating

More information

Antibiotic Resistance and Probiotics - A Metagenomic Viewpoint

Antibiotic Resistance and Probiotics - A Metagenomic Viewpoint Antibiotic Resistance and Probiotics - A Metagenomic Viewpoint Neerja Hajela, PhD General Manager-Science & Regulatory Affairs Yakult Danone India Pvt. Ltd. Outline of the Presentation Global Epidemiology

More information

Formulations and Availability 900 BILLION 5,319 HIGH POTENCY PROBIOTIC PEDIATRIC ADULT GERIATRIC PROVEN BY RESEARCH. HIGH-POTENCY. NO SHORTCUTS.

Formulations and Availability 900 BILLION 5,319 HIGH POTENCY PROBIOTIC PEDIATRIC ADULT GERIATRIC PROVEN BY RESEARCH. HIGH-POTENCY. NO SHORTCUTS. Formulations and Availability S TU D I E S PE R D I S E A S E 39 LIVER Liver Disease, Cirrhosis, Liver Failure, Hepatic Encephalopathy S TU D I E S PE R AG E G RO U P Visbiome Regular Product Code: 693-0412-01

More information

Study summaries L. casei 431

Study summaries L. casei 431 This binder provides you with summaries of selected publications on Lactobacillus paracasei subsp. paracasei L. casei 431. The publications are clinical studies performed in humans documenting the effects

More information

Clinically proven to quickly relieve symptoms of common gastrointestinal disorders. TERRAGASTRO - Good health starts in the gut

Clinically proven to quickly relieve symptoms of common gastrointestinal disorders. TERRAGASTRO - Good health starts in the gut Clinically proven to quickly relieve symptoms of common gastrointestinal disorders GASTROINTESTINAL DISEASE Referred to as gastrointestinal diseases, they are common disorders which affect the esophagus,

More information

PROBIOTICS are live microorganisms which, when ingested, confer a health benefits.

PROBIOTICS are live microorganisms which, when ingested, confer a health benefits. PROBIOTICS are live microorganisms which, when ingested, confer a health benefits. The most common types of microbes used as probiotics are lactic acid bacteria (LAB) and bifidobacteria, but some yeasts

More information

Probiotics. NOW Guide to Probiotics

Probiotics. NOW Guide to Probiotics Probiotics NOW Guide to Probiotics The Health Benefits of Probiotics Microorganisms for Health Did you know that you have trillions of microorganisms, including bacteria and yeast, living in and on your

More information

VITAMINS, MINERALS AND THE GUT

VITAMINS, MINERALS AND THE GUT VITAMINS, MINERALS AND THE GUT Nutrients Looking at individual nutrients that are involved with gut health can be misleading This is not about taking individual nutrients It supports more a whole food

More information

The impact of the microbiome on brain and cognitive development

The impact of the microbiome on brain and cognitive development The Gut-Brain Axis The impact of the microbiome on brain and cognitive development Diane Stadler, PhD, RD Oregon Health & Sciences University, Portland, Oregon Lao-American Nutrition Institute With acknowledgements

More information

Probiotic. Product Guide

Probiotic. Product Guide Probiotic Product Guide Product Quality Product Enhancements Sunfiber (Partially Hydrolyzed Guar Gum) Sunfiber promotes intestinal and colon health, and aids in the transit of food through the intestines.*

More information

השפעת חיידקים פרוביוטיים

השפעת חיידקים פרוביוטיים השפעת חיידקים פרוביוטיים החיים בחלל )המעי(... על רון שאול יחידת גסטרו ילדים מרכז רפואי רמב"ם Introduction The intestinal microflora primarily in the large bowel consists mostly on benign bacterial species

More information

Role of Food Matrix for Probiotic Effects

Role of Food Matrix for Probiotic Effects Role of Food Matrix for Probiotic Effects W. Kneifel Department of Food Science and Technology BOKU University of Natural Resources and Life Sciences Vienna Hohenheim, 15 Oct.. 2010 wolfgang.kneifel@boku.ac.at

More information

Developing the potential of prebiotics and probiotics as immune health ingredients

Developing the potential of prebiotics and probiotics as immune health ingredients Developing the potential of prebiotics and probiotics as immune health ingredients ARTHUR OUWEHAND ACTIVE NUTRITION DUPONT NUTRITION & HEALTH 20 th November 2014, The gut microbiome The gut microbiota

More information

WEBINAR Microbial Metabolism Associated with Health. 12 April 2018; CET

WEBINAR Microbial Metabolism Associated with Health. 12 April 2018; CET WEBINAR Microbial Metabolism Associated with Health 12 April 2018; 15.00-16.30 CET PROGRAMME Brief Introduction of Both Organisations and Scientific Background Dr Bettina Schelkle (ILSI Europe, BE) Dr

More information

Lactobacillus bulgaricus

Lactobacillus bulgaricus probiotic Lactobacillus bulgaricus Danone " : : * * * * * Bifidobacterium (LactobacillusCG) (Saccharomyce) (Bifidobacterium) (Antibiotic related diarrhea) GG L (Cytoprotection) B IgA lgg Probiotics -

More information

HMP is lead by NIH but is an International Consortium.

HMP is lead by NIH but is an International Consortium. Human Microbiome The Human Microbiome Project was one of the spin offs of the Human Genome Project. The HMP project started in 2007 with the overall goal of Characterizing the Human Microbiome and determine

More information

PROBIOTICS NEGATIVE ASPECTS

PROBIOTICS NEGATIVE ASPECTS PROBIOTICS NEGATIVE ASPECTS Dr Ismail Moola Department of Medical Gastroenterology CMJAH University of Witwatersrand Putative Benefits of Probiotics Modulate Immune Intestinal Function Increase secretory

More information

More than a gut feeling: How the microbiota improves health

More than a gut feeling: How the microbiota improves health More than a gut feeling: How the microbiota improves health Amanda Ramer-Tait, PhD Harold and Esther Edgerton Assistant Professor of Immunology and Microbiology Department of Food Science, University of

More information

Probiotics in IBS. Dr. Partha Pratim Das Associate Professor Dhaka Medical college

Probiotics in IBS. Dr. Partha Pratim Das Associate Professor Dhaka Medical college Probiotics in IBS Dr. Partha Pratim Das Associate Professor Dhaka Medical college Definitions Probiotics: Live microorganisms that confer a health benefit on the host when administered in adequate amounts.

More information

UNDERSTANDING PROBIOTIC SUPPLEMENTS

UNDERSTANDING PROBIOTIC SUPPLEMENTS Slide 1 UNDERSTANDING PROBIOTIC SUPPLEMENTS Slide 2 Probiotics Health Canada Definition: Probiotics are considered to be live microorganisms which, when administered in adequate amounts, confer a health

More information

THE MISSING PIECE IN AUTISM DIAGNOSIS: COULD WE BE OVERLOOKING THE GUT MICROBIOME?

THE MISSING PIECE IN AUTISM DIAGNOSIS: COULD WE BE OVERLOOKING THE GUT MICROBIOME? THE MISSING PIECE IN AUTISM DIAGNOSIS: COULD WE BE OVERLOOKING THE GUT MICROBIOME? ALTERNATIVEMEDICINE.COM SUBCONSCIOUS SUGGESTION: WE TRY HYPNOTHERAPY The Color Run: 5 TIPS TO BEAT THE BUGS HORSES THAT

More information

Probiotics in Pediatric Health. AANP Annual Convention

Probiotics in Pediatric Health. AANP Annual Convention Probiotics in Pediatric Health AANP Annual Convention Don Brown, ND July 12, 2017 Human Microbiome Richness and Metabolic Markers Human gut microbial composition was studied in 292 Danish adults Individuals

More information

UNDERSTANDING PROBIOTIC SUPPLEMENTS

UNDERSTANDING PROBIOTIC SUPPLEMENTS UNDERSTANDING PROBIOTIC SUPPLEMENTS Probiotics Health Canada Definition: Probiotics are considered to be live microorganisms which, when administered in adequate amounts, confer a health benefit on the

More information

PROBIONA. PROBIOTICS with 5 bacterial strains. Suitable during and after the use of antibiotics to restore intestinal microflora.

PROBIONA. PROBIOTICS with 5 bacterial strains. Suitable during and after the use of antibiotics to restore intestinal microflora. PROBIONA Probiotic supplement for adults PROBIOTICS with 5 bacterial strains Suitable during and after the use of antibiotics to restore intestinal microflora. 2.850 billion cfu per capsule guaranteed

More information

Probiotics- basic definition

Probiotics- basic definition Haworth Press 2007 Probiotics Terms: Probiotic Probiotics are live microorganisms (bacteria or yeasts) which, when administered in adequate amounts, confer a health benefit on the host Prebiotic - nutritional

More information

MegaSporeBiotics Probiotics. Linda Wilbert - Stewart, FDN, HHP, HC 1/28/

MegaSporeBiotics Probiotics.   Linda Wilbert - Stewart, FDN, HHP, HC 1/28/ MegaSporeBiotics Probiotics www.exclusivelyholistic.com Linda Wilbert - Stewart, FDN, HHP, HC 1/28/2015 111 MegaSporeBiotic is the first, all spore, carotenoid rich, probiotic consortium formulation on

More information

B. lactis LAFTI B94 DOCUMENTED PROBIOTIC STRAIN. DEDICATED TO HEARTY KIDS. B. lactis. Health claims. References. White paper

B. lactis LAFTI B94 DOCUMENTED PROBIOTIC STRAIN. DEDICATED TO HEARTY KIDS. B. lactis. Health claims. References. White paper White paper Health claims Natural and Non-prescription Health Products Directorate (NNHPD), the regulatory agency for natural health products in Canada, has approved health claims for, such as: Helps support

More information

Probiotics and Health

Probiotics and Health Probiotics and Health March 2015 TABLE OF CONTENTS EXECUTIVE SUMMARY... 2 BACKGROUND AND DEFINITIONS... 4 FUNCTIONAL GASTROINTESTIINAL DISORDERS... 5 Irritable bowel syndrome... 5 Constipation... 6 INFLAMMATORY

More information

Gut Microbiome Essentials

Gut Microbiome Essentials CORE COMPONENTS I: Gut Microbiome Essentials 2016 Tom Fabian, PhD Module Outline 1. Microbiome overview: getting a sense of the microbiome, research, what we know 2. Bacteria: features, functions, communities

More information

Guidance Document The Use of Probiotic Microorganisms in Food

Guidance Document The Use of Probiotic Microorganisms in Food Guidance Document The Use of Probiotic Microorganisms in Food Food Directorate Health Products and Food Branch Health Canada April 2009 Page 1 of 8 I. Introduction Purpose 1. The purpose of this Guidance

More information

The Gut Microbiome: 101 Justin Carlson University of Minnesota

The Gut Microbiome: 101 Justin Carlson University of Minnesota The Gut Microbiome: 101 Justin Carlson University of Minnesota Where are we now? 360 B.C. 2003 Human Gut Microbes Associated With Obesity Ley et al., Nature. 2006. Consumer Driven Science For Better of

More information

PROBIOTICS. The Ultimate Flora Difference

PROBIOTICS. The Ultimate Flora Difference In the Refrigerator Section! PROBIOTICS High-Potency Daily, Critical Care and Targeted Probiotic Formulas to Improve Regularity, Strengthen Natural Defenses and Promote Overall Digestion * The ReNew Life

More information

Update on Probiotic Use in Children with Diarrhoea

Update on Probiotic Use in Children with Diarrhoea Update on Probiotic Use in Children with Diarrhoea Ahmed Laving Paediatric Gastroenterologist and Senior Lecturer, University of Nairobi KPA Annual Scientific Meeting, Kisumu 2017 Outline Physiology of

More information

Shifts in the Intestinal Microbiota

Shifts in the Intestinal Microbiota Shifts in the Intestinal Microbiota Therapeutic Opportunities for Pre- and Probiotics? Kelly A. Tappenden, Ph.D., R.D., FASPEN Kraft Foods Human Nutrition Endowed Professor Editor-in-Chief, Journal of

More information

ULTIMATE FLORA PROBIOTICS

ULTIMATE FLORA PROBIOTICS ULTIMATE FLORA PROBIOTICS In the Refrigerator Section! High-Potency Daily, Critical Care and Targeted Probiotic Formulas to Improve Regularity, Strengthen Natural Defenses and Promote Overall Digestion*

More information

INTRODUCING YOUR GUT BACTERIA

INTRODUCING YOUR GUT BACTERIA INTRODUCING YOUR GUT BACTERIA Microflora Intestinal flora 1.5 kg We would die with 5 years of birth if we did not have them as we would not develop a proper immune system 1000 species and 5000 strains

More information

GUT MICROBIOME WHAT IS IT? WHY IS IT IMPORTANT FOR HUMAN HEALTH?

GUT MICROBIOME WHAT IS IT? WHY IS IT IMPORTANT FOR HUMAN HEALTH? GUT MICROBIOME WHAT IS IT? WHY IS IT IMPORTANT FOR HUMAN HEALTH? Corrie Whisner, PhD School of Nutrition and Health Promotion Arizona State University Center for Research on Ingredient Safety Annual Meeting

More information

SUPPORTING GUT HEALTH THROUGH CANCER TREATMENT. By Marina Silverio, RHN and Lorene Sauro, RHN

SUPPORTING GUT HEALTH THROUGH CANCER TREATMENT. By Marina Silverio, RHN and Lorene Sauro, RHN SUPPORTING GUT HEALTH THROUGH CANCER TREATMENT By Marina Silverio, RHN and Lorene Sauro, RHN Working With Cancer Clients Clients come to us as a secondary practitioners Our role is one of support The biggest

More information

TOP 10 LEAKY GUT SUPPLEMENTS

TOP 10 LEAKY GUT SUPPLEMENTS TOP 10 LEAKY GUT SUPPLEMENTS HEALING LEAKY GUT Leaky Gut Supplements Leaky gut syndrome is a condition where undigested proteins like gluten, toxins and microbes can pass into the bloodstream. Another

More information

Homeopathic Products. Evidence??

Homeopathic Products. Evidence?? Homeopathic Products Principle of analogy or Law of Similars Small or infinitesimal doses (3X-30C) Avogadro s number=6x10 23 = ~23X Succussion and potentization (see http://www.boiron.com/en/htm/02_medi_hom

More information

An Overview on the Global Market of Dietary Supplements

An Overview on the Global Market of Dietary Supplements An Overview on the Global Market of Dietary Supplements Abbas Kebriaeezadeh 1 and Alireza Yektadoost 2 Department of Pharmacoeconomics & Pharmaceutical Administration Faculty of Pharmacy, Tehran University

More information

Probiotics: Their Role in Medicine Today. Objectives. Probiotics: What Are They? 11/3/2017

Probiotics: Their Role in Medicine Today. Objectives. Probiotics: What Are They? 11/3/2017 Probiotics: Their Role in Medicine Today Viki Barr Pharm.D., BCPS AQ ID Assistant Professor, Pharmacy Practice Rosalind Franklin University of Medicine and Science Clinical Pharmacist, Infectious Diseases

More information

Probiotics for Primary Prevention of Clostridium difficile Infection

Probiotics for Primary Prevention of Clostridium difficile Infection Probiotics for Primary Prevention of Clostridium difficile Infection Objectives Review risk factors for Clostridium difficile infection (CDI) Describe guideline recommendations for CDI prevention Discuss

More information

THE PROBIOTIC PRODUCT RANGE HAS SET A NEW INDUSTRY STANDARD BY OFFERING THREE PRODUCTS WITH A PROVEN POTENCY MULTI STRAIN BACTERIA AT THE TIME OF

THE PROBIOTIC PRODUCT RANGE HAS SET A NEW INDUSTRY STANDARD BY OFFERING THREE PRODUCTS WITH A PROVEN POTENCY MULTI STRAIN BACTERIA AT THE TIME OF THE PROBIOTIC PRODUCT RANGE HAS SET A NEW INDUSTRY STANDARD BY OFFERING THREE PRODUCTS WITH A PROVEN POTENCY MULTI STRAIN BACTERIA AT THE TIME OF CONSUMPTION WHICH ARE STABLE AT NORMAL ROOM TEMPERATURE

More information

Our microbiome: The role of vital gut bacteria, diet, nutrition and obesity

Our microbiome: The role of vital gut bacteria, diet, nutrition and obesity Our microbiome: The role of vital gut bacteria, diet, nutrition and obesity Prof Kevin Whelan Professor of Dietetics King s College London @ProfWhelan #BSG2017 Speaker Declarations This presenter has the

More information

Influence of healthy eating on market trends. Paul Paquin, Ph.D. INAF, Université Laval, Québec

Influence of healthy eating on market trends. Paul Paquin, Ph.D. INAF, Université Laval, Québec Influence of healthy eating on market trends Paul Paquin, Ph.D. INAF, Université Laval, Québec Key Trends TREND A key trend is one that represents a genuine growth opportunity On which a company can base

More information

Bacteriology. Mycology. Patient: SAMPLE PATIENT DOB: Sex: MRN: Rare. Rare. Positive. Brown. Negative *NG. Negative

Bacteriology. Mycology. Patient: SAMPLE PATIENT DOB: Sex: MRN: Rare. Rare. Positive. Brown. Negative *NG. Negative Patient: SAMPLE PATIENT DOB: Sex: MRN: 3.2 0.9-26.8 U/g 1.2 0.2-3.3 mg/g 2.2 1.3-8.6 micromol/g 1.1 1.3-23.7 mg/g 1.1 0.2-3.5 mg/g Rare 1.0 0.2-8.8 mg/g Rare 4.4 2.6-32.4 mg/g 64.6 >= 13.6 micromol/g Bacteriology

More information

A Randomized Open Label Comparative Clinical Study of a Probiotic against a Symbiotic in the Treatment of Acute Diarrhoea in Children

A Randomized Open Label Comparative Clinical Study of a Probiotic against a Symbiotic in the Treatment of Acute Diarrhoea in Children International Journal of Medical Research & Health Sciences Available online at www.ijmrhs.com ISSN No: 2319-5886 International Journal of Medical Research & Health Sciences, 2017, 6(9): 96-100 I J M R

More information

Translating the science into efficacy claims on probiotic or prebiotic products in the US market

Translating the science into efficacy claims on probiotic or prebiotic products in the US market Translating the science into efficacy claims on probiotic or prebiotic products in the US market American Dairy Science Association Annual Meeting July 13, 2010 Dairy & Food Culture Technologies Consulting

More information

Healthy Gut, Healthy Body

Healthy Gut, Healthy Body September 2018 Healthy Gut, Healthy Body Science tells us that the bacteria in our bodies outnumber our cells 10 to 1. And it s supposed to be that way. Research has shown that the human microbiome, an

More information

Irritable Bowel Syndrome

Irritable Bowel Syndrome + 1 Irritable Bowel Syndrome - Overview - Details of an independent study carried out by University College London to establish if 8 leading probiotics are effective as they claim 1 + Irritable Bowel Syndrome

More information

P A T I E N T H A N D B O O K

P A T I E N T H A N D B O O K PATIENT HANDBOOK Heal Your Gut, Heal Your Body The gastrointestinal (GI) tract is one of the most sophisticated systems of the human body. We often think of the GI tract for its primary role in digesting

More information

The plain curd brands were prepared from. Curd (Dahi) Health food, yes, but is it adulteration-free? Comparative Test. A Consumer Voice Report

The plain curd brands were prepared from. Curd (Dahi) Health food, yes, but is it adulteration-free? Comparative Test. A Consumer Voice Report Comparative Test Curd (Dahi) Health food, yes, but is it adulteration-free? Any number of health benefits are attributed to good old curd. Heart health, bone health, teeth health, immunity boost, you name

More information

The Gut Factor. Probiotics, the gut microbiome and human health. Thursday November 10, 2016 l 12:00 pm

The Gut Factor. Probiotics, the gut microbiome and human health. Thursday November 10, 2016 l 12:00 pm The Gut Factor Probiotics, the gut microbiome and human health Thursday November 10, 2016 l 12:00 pm Dr. Elena Comelli is an Assistant Professor and holds the Lawson Family Chair in Microbiome Nutrition

More information

PROSPERO International prospective register of systematic reviews

PROSPERO International prospective register of systematic reviews PROSPERO International prospective register of systematic reviews The effect of probiotics on functional constipation: a systematic review of randomised controlled trials EIRINI DIMIDI, STEPHANOS CHRISTODOULIDES,

More information

An Overview of Guidelines and Regulations for Probiotics

An Overview of Guidelines and Regulations for Probiotics An Overview of Guidelines and Regulations for Probiotics Virender K. Batish Molecular Biology Unit Di Dairy Microbiology bil Division, Diii NDRI, Karnal (Haryana) 132 001, INDIA Probiotics the magic bugs

More information

Pthaigastro.org. Drugs Used in Acute Diarrhea: Cons. Nipat Simakachorn, M.D. Department of Pediatrics Maharat Nakhon Ratchasima Hospital.

Pthaigastro.org. Drugs Used in Acute Diarrhea: Cons. Nipat Simakachorn, M.D. Department of Pediatrics Maharat Nakhon Ratchasima Hospital. Drugs Used in Acute Diarrhea: Cons Nipat Simakachorn, M.D. Department of Pediatrics Maharat Nakhon Ratchasima Hospital 27-Apr-2012 Optimistic Pessimistic Global percentage of children

More information

Trend and Innovation of Pro and Prebiotics in Dairy Industry

Trend and Innovation of Pro and Prebiotics in Dairy Industry Emerging Dairy Ingredients: Innovation, Safety & Functionality Bogor, 9 June 2011 Trend and Innovation of Pro and Prebiotics in Dairy Industry Lilis Nuraida Southeast Asia Food and Agricultural Science

More information

Probiotics in the ICU. Who could benefit? Nadia J van Rensburg RD(SA) Groote Schuur Hospital, Cape Town

Probiotics in the ICU. Who could benefit? Nadia J van Rensburg RD(SA) Groote Schuur Hospital, Cape Town Probiotics in the ICU. Who could benefit? Nadia J van Rensburg RD(SA) Groote Schuur Hospital, Cape Town Outline Introduction: a brief overview Probiotics: Current guidelines Reviews and Meta-analyses IBD

More information

Which foods may carry nutrition and health claims? Update from EFSA

Which foods may carry nutrition and health claims? Update from EFSA Which foods may carry nutrition and health claims? Update from EFSA Leng HENG Unit on Dietetic Products, Nutrition and Allergies (NDA) EFET Conference - 22 Oct 2010, Athens 1 2 Outline EFSA Panel on Dietetic

More information

The Intestinal Microbiota and the Developing Immune System

The Intestinal Microbiota and the Developing Immune System The Intestinal Microbiota and the Developing Immune System 4 Feb 2016 The Intestinal Microbiota 10 fold more bacterial cells than human cells 100-1000 fold more bacterial genes than human genes Why does

More information

Regulatory challenges in the drug-food continuum. Yolanda Sanz IMI Stakeholder Forum Microbiome Brussels, Belgium

Regulatory challenges in the drug-food continuum. Yolanda Sanz IMI Stakeholder Forum Microbiome Brussels, Belgium Regulatory challenges in the drug-food continuum Yolanda Sanz 19.10.2017 IMI Stakeholder Forum Microbiome Brussels, Belgium Outline Regulation of health claims on foods EU No 1924/2006 Reconciling science

More information

Microbiome GI Disorders

Microbiome GI Disorders Microbiome GI Disorders Prof. Ram Dickman Neurogastroenterology Unit Rabin Medical Center Israel 1 Key Points Our gut microbiota Were to find them? Symbiosis or Why do we need them? Dysbiosis or when things

More information

Bio Pro 365. Product Summary. Ingredients. Prebiotic Probiotic Blend. Bio Pro 365 is a comprehensive and clinically-tested pre- and probiotic blend

Bio Pro 365. Product Summary. Ingredients. Prebiotic Probiotic Blend. Bio Pro 365 is a comprehensive and clinically-tested pre- and probiotic blend Bio Pro 365 Prebiotic Probiotic Blend Product Summary Bio Pro 365 is a comprehensive and clinically-tested pre- and probiotic blend specifically designed to protect and enhance all aspects of the digestion

More information

The effect of probiotics on animal health: a focus on host s natural intestinal defenses

The effect of probiotics on animal health: a focus on host s natural intestinal defenses The effect of probiotics on animal health: a focus on host s natural intestinal defenses Guillaume Tabouret Animal Health Dept. Joint Unit 1225 Host Pathogens Interactions History of probiotics and definition

More information

Plexus VitalBiome Healthy gut. Happy mind.

Plexus VitalBiome Healthy gut. Happy mind. Plexus VitalBiome Healthy gut. Happy mind. A revolutionary probiotic supplement that contains eight clinically studied probiotic strains that help improve health and mood while reducing feelings of stress

More information

Gut Microbiota and IBD. Vahedi. H M.D Associate Professor of Medicine DDRI

Gut Microbiota and IBD. Vahedi. H M.D Associate Professor of Medicine DDRI Gut Microbiota and IBD Vahedi. H M.D Associate Professor of Medicine DDRI 1393.3.1 2 GUT MICROBIOTA 100 Trillion Microbes - 10 times more than cells in our body Collective weight of about 1kg in human

More information

ROLE OF THE GUT BACTERIA

ROLE OF THE GUT BACTERIA ROLE OF THE GUT BACTERIA Our Good Bacteria In a perfect world, we would all have a proper ratio of good bacteria And what could this proper ratio do for us? The knowledge of the connections between our

More information

Probiotics and Irritable Bowel Syndrome

Probiotics and Irritable Bowel Syndrome Probiotics and Irritable Bowel Syndrome (IBS) Information for patients Sheffield Dietetics page 2 of 8 Is there bacteria in the gut? The human gut contains millions of bacteria. These bacteria play an

More information

Digestive Health. Sponsored by:

Digestive Health. Sponsored by: Digestive Health Sponsored by: Highlighting the key trends and future directions for innovation in the digestive health space Speaker: Robin Wyers, Chief Editor, Innova Market Insights (The Netherlands)

More information

11/2/2016. Objectives. Definition of probiotics. What is and what is not a probiotic? What is and what is not a probiotic?

11/2/2016. Objectives. Definition of probiotics. What is and what is not a probiotic? What is and what is not a probiotic? A Consumer s Guide to Probiotics and Health Wellness Wednesday November 2, 2016 Wendy Dahl RD PhD FDC Associate Professor, Food Science and Human Nutrition, UF/IFAS Objectives To outline current evidence

More information

Dr Warren Hyer Consultant Paediatric Gastroenterologist

Dr Warren Hyer Consultant Paediatric Gastroenterologist Dr Warren Hyer Consultant Paediatric Gastroenterologist Probiotics a cure for all? No conflict of interest to declare Aims To change your opinion of probiotic use in children To base your decision on high

More information

Choosing the Right Probiotic

Choosing the Right Probiotic Choosing the Right Probiotic Robert Dadd Master Herbalist : Flora Health Canada What is the Microbiome? The community of microorganisms that inhabits our bodies Skin, mouth, nose, digestive tract, and

More information

Assessing and Maintaining Probiotics in Food

Assessing and Maintaining Probiotics in Food Assessing and Maintaining Probiotics in Food Tina Hornbæk, PhD Senior Research Scientist Fermented Milk & Probiotics Cultures & Enzymes Division Chr. Hansen, Denmark Outline Trends in the market for probiotic

More information

Regulation of Foods Containing Probiotics - Codex Alimentarius, Japan, European Union and India

Regulation of Foods Containing Probiotics - Codex Alimentarius, Japan, European Union and India 1 International Journal of Fermented Foods: v.3.n.1 p-1-10 June 2014 2014 New Delhi Publishers. All rights reserved DOI No. 10.5958/2321-712X.2014.01306.4 Review Paper Regulation of Foods Containing Probiotics

More information

What are probiotics? How do probiotics benefit health?

What are probiotics? How do probiotics benefit health? The culture club So, you re clean eating, gluten free, fasting, eating avocados like their going out of fashion, chugging down green juices with the latest wonder powders and using coconut oil to cook

More information

Increasing barrier function with multispecies probiotics

Increasing barrier function with multispecies probiotics Increasing barrier function with multispecies probiotics Elsbeth Pekelharing, MSc Science Liaison We strive for the most effective microbiome management solutions with our evidence-based & indication-specific

More information

The good, the bad and the ugly. Our microbiome and it s effect on health and disease.

The good, the bad and the ugly. Our microbiome and it s effect on health and disease. The good, the bad and the ugly Our microbiome and it s effect on health and disease. Objectives Discuss C difficile infection including treatment options Explain process of Fecal MicrobiotaTransplantation

More information

Module Four: The GI System Module Five: The Gut Microbiome. The GI System. LLiana Shanti, CN

Module Four: The GI System Module Five: The Gut Microbiome. The GI System. LLiana Shanti, CN Module Four: The GI System Module Five: The Gut Microbiome The GI System LLiana Shanti, CN www.healthmasteryinstitute.com Review Review Review The Gut Hippocrates has been quoted as saying death sits in

More information

2/3/2011. Adhesion of Bifidobacterium lactis HN019 to human intestinal

2/3/2011. Adhesion of Bifidobacterium lactis HN019 to human intestinal PROBIOTICS LEARNING THE WHY AND WHEN PROBIOTICS DEFINITION live micro-organisms organisms that are beneficial to the host organism WHO: Live organisms which, when administered in adequate amounts, confer

More information