The GUNA Pharmacology

Transcription

1 The GUNA Pharmacology Remedies from: HOMEOPATHY AND HOMOTOXICOLOGY Remedies from: P.N.E.I. Minerals Amino acids Trace elements Physiological Regulating Therapy (GUNA Method)

2 MACROCOSMOS OF GUNA-METHOD THERAPEUTIC STRATEGY MICROCOSMOS OF GUNA-DRUGS BASIC STRUCTURE

3 GUNA METHOD - THE THERAPEUTIC STRATEGY 1 P.N.E.I. REBALANCE 4 5 CELL NUTRITIONAL SUPPORT CELL METABOLIC SUPPORT 2 3 DRAINAGE CONTROL OF SYMPTOMS LYMPHATIC DRAINAGE MATRIX DRAINAGE CELL DRAINAGE ORGANS OF ELIMINATION DRAINAGE

4 GUNA METHOD - THE THERAPEUTIC STRATEGY LYMPHATIC DRAINAGE DISEASE MATRIX DRAINAGE HEALING 2. DRAINAGE CELL DRAINAGE 3. CONTROL OF SYMPTOMS CELL METABOLIC SUPPORT ORGANS OF ELIMINATION DRAINAGE CELL NUTRITIONAL SUPPORT 1. P.N.E.I. REBALANCE

5 GUNA DRUGS BASIC STRUCTURE 3 CONTROL OF SYMPTOMS Modulating local or systemic phlogosis 2 DRAINAGE Restoring matrix and emunctory organs function CELL NUTRITIONAL SUPPORT Classic Homeopathy and Homotoxicology Remedies 4 5 Inducing protein synthesis. Antioxidative protection Minerals, Oligonutrients Vitamins, Oligonutrients Cytokines, Hormones, Homeopathic Neurotransmitters CELL METABOLIC SUPPORT Restoring physiological metabolic balance 1 P.N.E.I. REBALANCE Restoring neuro-immuneendocrine-physiological function

6 DRAINAGE: a detoxified and drained extra-cellular matrix will allow a cell to receive oxygen and nutrients and its receptors to be adequately activated by the relation molecules. A detoxified and drained cell will be able to perform its metabolic function. The emunctory organs, activated by specific drainage remedies, will strengthen their physiological excretory and toxin-release function.

7 CELL METABOLIC SUPPORT: the action of a relation molecule on the membrane receptors or on the receptors of any other homeopathic remedy acting on the cell would not be responsive if the cell were not in such an energetic condition to be reactive. The cell metabolic stimulation is therefore a necessary step in view of a therapeutic success. Vitamins, minerals, oligonutrients and above all homeopathic microdoses of Krebs cycle salts and quinones activate the mitochondrion as if they were real energy reservoirs and restore the highest ATP synthesis capacity.

8 P.N.E.I. REBALANCE: reprogramming the neuroimmune-endocrine axis in both directions, namely psychosomatic and somatopsychic, is the core of Physiological Regulating Therapy. According to a sophisticated biological mechanism Homeopathic micro doses of cytokines, hormones and neurotransmitters as much concentrated as in a physiological milieu - and selected homeopathic remedies (of plantvegetal, mineral or animal origin) once introduced into the human body are capable of reducing, modulating and stimulating the reactivity of the 3 Great Systems (Nervous, Immune and Endocrine) and guidingleading it back within its physiological range without suppressing or inhibiting a biological response.

9 CELL NUTRITIONAL SUPPORT: nutrients (proteins, carbohydrates, lipids) can have an essential role in maintaining or restoring health: the most advanced research studies in the nutrition field have defined the typology, the metabolic routes and above all the adequate amounts of each nutrient stating that small and balanced amounts of aminoacids, vitamins and, oligonutrients are sufficient and necessary for a correct bios functioning. Guna s remedies contain small (oligos) and appropriate (orto) amounts of nutrients. This is extremely important as they protect biological structures from free radicals, which are particularly harmful in chronic and degenerative diseases as well as in the ageing process.

10 CONTROL OF SYMPTOMS: as in a perfect team play, interleukins, neurotransmitters, homeopathic hormones and as well as classic homeopathy remedies act on inflammatory diseases, thus leading to recovery. Among these substances, the specific remedies for every evolutionary phase of the inflammatory process can be identified and their action is simply extraordinary: calor, dolor, rubor, tumor, all of them being modulated thus leading to a natural recovery. It s a new therapeutic concept coming from homeopathic tradition and as a result of research studies in the field of molecular Biology: homeopathic micro doses of the molecules conveying immune response are capable of reactivating an adequate biological immune response (as much concentrated as in a physiological milieu). The phlogosis process is therefore being modulated - thus evolving and leading to a full recovery and considerable reduction of prognosis time.

11 GUNA-MATRIX SYMPTOMS CONTROL Modulating local or systemic phlogosis CELL NUTRITIONAL SUPPORT -TYROSINE 2X -PHENYALANINE 2X -HISTIDINE 2X Classical homeopathic and homotoxicological Remedies Minerals, Oligonutrients Vitamins, Trace elements Cytokines, Hormones, Homeopathic Neurotransmitters DRAINAGE -PYROGENIUM 12X - FUCUS 3X -THUJA 8X -NATRUM SULFURICUM 8X - CONJUNCTIVA TISSUE 6X - LYMPHATIC VESSELS 6X -HYALURONIDASE 6X CELL METABOLIC SUPPORT -ASCORBIC ACID 2X - KREBS CIRCLE CATALYSTS 6X P.N.E.I. REBALANCE -IL 64C -PROLACTINE 6X -DHEA 6X

12 1 ST GUNA PHARMACOLOGY PRINCIPLE SYNERGISM GUNA COMPLEXES BALANCE COMPLETENESS

13 SYNERGISM: the remedies boost each other in a syergistic way. The global effect is higher than the summation of the single remedies effects. BALANCE: In the drugs remedies are in quantity and diluitions as to re-balancing, without altering, neuro-immuneendocrine homeostasis. COMPLETENESS: the remedies are associated so that every step of the etiopathogenetic cascade and every possible symptomatologic expression of the pathology, the drug is indicated for, is considered.

14 2 nd GUNA PHARMACOLOGY PRINCIPLE Farmaci Alcool Infezioni Intossicazioni alimentari Alterazione della secrezione acida Infiammazione della mucosa gastrica Pirosi Acidità Ulcera peptica Gastrite cronica Sintomatologia gastrica ed epigastrica Reazione catarrale IN THE HOMEOPHARMACOLOGIC STRUCTURE OF THE GUNA METHOD COMPLEX MEDICINES IS INSCRIBED THE ETIOPATHOGENETIC PROCESS OF THE PATHOLOGY IT WILL TREAT

15 3 rd GUNA PHARMACOLOGY PRINCIPLE rd 2002 Dipartimento Scientifico Guna GUNA PHARMACOLOGY PRINCIPLE The pace maker of GUNA drugs THE GUNA COMPLEXES ARE THERAPEUTIC UNITS IN WHICH THE REMEDIES ARE GATHERED SO THAT EVERY STEP OF THE ETIOPATHOGENETIC CASCADE OF THE PATHOLOGY IS SATURATED IN THE RESPECT OF THE TEMPORAL SEQUENCE OF A CORRECT BIOLOGICAL THERAPY.

16 TRAUMATOLOGY GENERAL PART 16

17 GUNA -TRAUMA drops Organotrophism and carrier function for homologous human tissues Connective 12/30/200X Bone 12/30/200X Cartilago 12/30/200X ORGANOTHERAPIC CORE PHYTO-HOMEOPATHIC CORE Chamomilla 1X* Hypericum 3X* Arnica 3X** Hamamelis 2X** Bellis 2X*** Calendula 1X**** Symphytum 3X**** Ruta 3X Kalmia 8X Rhus tox. 6X Bryonia 6X Stop to IL1, starter of inflammatory process* The stimulation of the cytokines having Th2-Th3 polarity modulates inflammation** Analgesic action*** PNEI CORE Anti IL 1 4C* TGF-beta 1** IL 10** Beta-Endorphin 6X*** Modulation of all inflammatory process development phases (neurogen*, vasal**, exudative***, restitutio ad integrum****) Tropism remedies, specific for bones, muscles, tendons, ligaments, synovia Activity aimed at all the functional components of orthotraumatologic pain 17

18 SYMPTOMS CONTROL ACONITUM 6/12/30/200X APIS 6/12/30/200X BELLADONNA 6/12/30/200X FERRUM PHOSP. 6/12/30/200X HEPAR SULF. 6/12/30/200X PYROGENIUM 30/200X BRYONIA 6/12/30/200X PHYTOLACCA 6/12/30/200X CELL NUTRITIONAL SUPPORT Protein synthesis Antioxidative protection Oligonutrients GUNA -FLAM drops Classic Homeopathic and and Homotoxicological Remedies Cytokines,, Hormones,, Homeopathic Neurotransmitters Minerals, Vitamins,, Trace elements DRAINAGE CONNECTIVE TISSUE 12/30/200X CELL METABOLIC SUPPORT COPPER GLUCONATE 4X NATRUM PYRUVICUM 3X ACIDUM CITRICUM 3X P.N.E.I. REBALANCE ANTI -IL 1 4C TGF- β 1 4C IL 10 4C MELATONINE 6X β-endorphin 6X HYPOPHYSIS 200X PINEAL GLAND 6X 18

19 SYMPTOMS CONTROL Modulating local or systemic inflammation phlogosis CELL NUTRITIONAL SUPPORT -TYROSINE 2X -PHENYALANINE 2X -HISTIDINE 2X GUNA -MATRIX drops Classic Homeopathic and Homotoxicological Remedies Minerals, Vitamins, Oligonutrients Trace elements Cytokines,, Hormones,, Homeopathic Neurotransmitters DRAINAGE - PYROGENIUM 12X - FUCUS 3X -THUJA 8X - NATRUM SULFURICUM 8X - CONJUNCTIVA TISSUE 6X - LYMPHATIC VESSELS 6X - HYALURONIDASE 6X CELL METABOLIC SUPPORT -ASCORBIC ACID 2X - KREBS CYCLE CATALYSTS 6X P.N.E.I. REBALANCE -IL 64C - PROLACTINE 6X -DHEA 6X 19

20 GUNA -LYMPHO drops Reduction of local inflammation on lymphoepithelial tissues Reduction of lymphatic spasm on inflammatory basis with consequent restoration of the lymphatic circulation Calendula Phytolacca Apis Magnesia phosph. Humoral immunity stimulation and inhibitory modulation of the excessive cell mediated compensatory response REACTIVATION OF THE LYMPHATIC CIRCULATION ANTI-INFLAMMATORY ACTIVITY ON LYMPHOEPITELIAL TISSUES Myosotis Equisetum Hydrocotile Taraxacum Sarsaparilla Lymphatic vessel Capillary tisssue L-Thyroxin Vena STRENGHTENING OF THE IMMUNE DEFENCE Magnesium phosphoricum Juglans regia HYPERTROPHY AND HYPERPLASY OF LYMPHATIC ORGANS D-L Malic Ac./Fumaricum Ac./Pyruvicum Ac. Trychinoil/Natrium oxalac. Lymphagogue action and stabilization of vasal walls tone with consequent reduction of exudate and lymphoedema Hydrastis Juglans Graphites Hindrance to the proliferative proneness of lymphoepitelial tissues 20

21 TRAUMATOLOGY MUSCULAR LESIONS 1 EXTERNAL CAUSES = MUSCULAR CONTUSION : acute pain, swelling, painful tumefaction, (in case) hematoma THERAPY GUNA MUSCLE AMPOULES + GUNA NEURAL AMPOULES GUNA TRAUMA DROPS GUNA MATRIX DROPS GUNA FLAM DROPS DROPS: 10 drops 3 times a day, 15 minutes before meal INTERNAL CAUSES = MUSCLE ELONGATION MUSCULAR CONTRACTION STRETCHING THERAPY GUNA MUSCLE AMPOULES + GUNA NEURAL AMPOULES GUNA TRAUMA DROPS GUNA LYMPHO DROPS 21

22 TRAUMATOLOGY TENDINITIS: edema, heat, tendon stiffness tendinitis TENDINITIS 80% in Sport Medicine 2 tendosynovitis tendoperiostitis THERAPY etc. 1) CALCANEAN TENDON: GUNA HAND/FOOT AMPOULES GUNA MATRIX DROPS GUNA FLAM DROPS 2) BICIPITAL TENDINITIS: GUNA SHOULDER AMP. + GUNA MUSCLE AMP. GUNA FLAM DROPS GUNA MATRIX DROPS 3) TENDON PAIN FROM CASTS: GUNA HANDFOOT AMPOULES GUNA MATRIX DROPS GUNA LYMPHO DROPS 4) PUBIC PAIN: GUNA HIP AMPOULES GUNA FLAM DROPS GUNA LYMPHO DROPS GUNA MATRIX DROPS 22

23 TRAUMATOLOGY FRACTURES 3 OSTEOBIOS TM DROPS GUNA ARTHRO DROPS GUNA MATRIX DROPS GUNA FLAM DROPS + GUNA.. AMPOULES according to the anatomic localization (e.g. fracture of femor neck: GUNA HIP, fracture of hand bones: GUNA HANDFOOT) THERAPY DISLOCATIONS GUNA FLAM DROPS GUNA ARTHRO DROPS GUNA MATRIX DROPS GUNA LYMPHO DROPS in case of shoulder dislocation: add GUNA SHOULDER AMPOULES THERAPY 23

24 TRAUMATOLOGY PERIPHERAL NERVE NERVE LESIONS LESIONS 4 THERAPY COMPRESSION SYNDROMES SPRAIN SYNDROMES (BRACHIAL PLEXUS) POSTOPERATIVE PARESIS GUNA NEURAL AMPOULES GUNA FLAM DROPS GUNA MATRIX DROPS GUNA TRAUMA DROPS SYNDROMES DUE DUE TO TO HYPEREXTENSION HYPERFLEXION GUNA NECK AMPOULES GUNA THORACIC AMPOULES THERAPY GUNA LUMBAR AMPOULES 24

25 25

26 FIBROMYALGIA Fibromyalgia is not a new syndrome but a resurrection of the old diagnosis fibrositis Fibromyalgia syndrome is a very common chronic illness whose pathogenesis is reported to be poorly understood Women are more affected than men All races are affected 26

27 FIBROMYALGIA DIAGNOSIS: the patient has to constantly experience the symptoms for more than 3 4 months and have at least 10 Trigger Points into the 18 classical sites + disturbed sleep Commonly associated conditions: irritable bowel syndrome, migraine, phychic depression, obstructive sleep apnoea, general fatigue Several causes have been identified: stress, tension, chill, connective tissue diseases such as 1) osteoarthritis, nerve compression, endocrine imbalance (estrogen deficiency, hypothyroidism) 2) traumas, repetitive strain, overuse 3) physical mental fatigue, anxiety LAB TESTS AND X RAY: NEGATIVE FOR SPECIFIC DIAGNOSIS 27

28 FIBROMYALGIA SYNDROME LOCAL THERAPY GUNA MUSCLE + GUNA NEURAL 2 ampoules (4 ml) + 1 ampoule (2 ml) = 6 ml INTO EACH TRIGGER POINT: 0.5 ml TRIGGER POINTS INJECTED PER SESSION: NUMBER OF SESSIONS:

29 FIBROMYALGIA SYNDROME HOME THERAPY Example: GUNA FLAM DROPS GUNA MATRIX DROPS 15 drops 3 times a day 9am 3pm 9pm 15 drops 3 times a day 9.30am 3.30pm 9.30pm GUNA SLEEP DROPS drops a day pm Duration of the therapy: 2 months 29

30 PAIN MANAGEMENT - LOCAL THERAPY - 30

31 Type of needle Select application site according to acupuncture points, trigger points, tender points, referred pain zones, nerve key points, Head zones or local pain points. Using a 13 mm 30G, a 4 mm 27G, or an insulin needle, make the classic intradermal or subcutaneous injection according to mesotherapic technique.

32 GUNA -NECK Chart of area/zone connections GUNA -SHOULDER GUNA -THORACIC GUNA -HIP GUNA -LUMBAR GUNA -ISCHIAL GUNA -HANDFOOT GUNA -NEURAL Nerve pain GUNA -POLYARTHRITIS Joint pain GUNA -MUSCLE Muscle pain

33 NEW & INNOVATIVE PAIN MANAGEMENT INJECTABLE AMPOULES FORMULATIONS ARE EXTREMELY SPECIFIC & SELECTIVE FOR OSTEO ARTHRO MYOFASCIAL PATHOLOGIES OF EVERY SINGLE ANATOMIC PART In Pain Management injectable ampoules (10), 60 low dose homeopathic unitary remedies are contained: only 4: 1) ARNICA (Arnica montana) 2) ACONITUM (Aconitum napellus) 3) RHUS TOX. (Rhus toxicodendron) 4) CIMICIFUGA (Cimicifuga racemosa) 9 out of 10 contain Beta Endorphin (except for GUNA MUSCLE) 8 out of 10 contain Anti IL1α; Anti IL1β (except for GUNA MUSCLE and GUNA NEURAL)

34 INTERLEUKIN 1 Interleukin 1 (IL-1) is a cytokine secreted by different type of cells of the Immune System (macrophages, monocytes, dendritic cells, fibroblasts and endothelial cells) IL-1 = first discovered IL-1 has various effects on the organism both at general and local level One of these effects is to support inflammatory processes; moreover it stimulates prostaglandins production from different type of cells (muscular, epithelial, etc.), the production of other cytokines (among which IL-2) and the activation and recruitment of other cells of the Immune System: -IL-1α -IL-1 β Those two classes have similar activities but different structures

35 INTERLEUKIN 1 IL 1 IS A PIVOTAL PRO INFLAMMATORY CYTOKINE CENTRALLY INVOLVED IN IMMUNE SYSTEM SYSTEMIC AND LOCAL RESPONSES LEADING TO TYPICAL EFFECTS OF INFLAMMATION DYSREGULATED, PROLONGED SYNTHESIS AND RELEASE OF IL 1 IN CHRONIC INFLAMMATORY SITUATIONS CONTRIBUTE TO A NUMBER OF DISEASES, e.g. RHEUMATOID ARTHRITIS

36 IL 1 ACTIVATES MONOCYTES/ MACROPHAGES INDUCES FIBROBLASTS PROLIFERATION ACTIVATES CHONDROCYTES ACTIVATES OSTEOBLASTS INFLAMMATION SYNOVIAL PANNUS FORMATION CARTILAGE BREAKDOWNS BONE RESORPTION

37 Why use Anti Interleukins (1) Alpha and Beta in the pain management formulas? Interleukins 1 (IL1α; IL1ß) are the most active primary mediators from a biological point of view, secreted by Th1 cells to induce inflammation (Phase A) by means of their own capacity to stimulate the genic expression associated with the whole inflammatory process evolution Even though structurally different (codified by 2 different genes), they act on the same specific receptor. IL1 have a very short half life and are secreted by IL1 themselves when in contact with CD4 lymphocytes IL1 (α; ß) activate cyclooxygenase type 2 (COX2) (A), prostaglandin E2 (B) and nitric oxide (C), so activating the inflammatory process (pro inflammatory Interleukins) As a consequence, Anti Interleukins 1 (α; ß) act as NSAIDs (A), cortisone (B) and, in part, as salicylates (C), without the negative side effects caused by these allopathic medicines. Consequently, homeopathically diluted Anti IL1 α and ßare successfully used in osteo arthro myalgic pain management therapy (according to Physiological Regulating Medicine Guna Method)

38 What is the scientific reason for using Anti Interleukins and not Interleukins having anti inflammatory properties? Anti inflammatory Interleukins (mainly IL10) are secreted by Th2 cells after the activation of Th1 cells (Phase B of Hoff s Commutative Reaction) and, as a consequence, they act after Interleukins 1 α and ßsecretion The block of Interleukins 1 α and ß (anti) is therefore more effective than the stimulation of IL10 IL10 has more anti inflammatory action above all in chronic forms than in acute forms

39 INFLAMMATION PHASE A = DEVELOPMENT PHASE B = RESOLUTION YES NO RECOVERY CHRONICIZATION

40 & inflammation development (mesenchyme hydrolysis, tissue acidosis, sympathetic tone, proinflammatory cytokines release: IL1α, IL1β, TNFα, IL12, IL15, IL18, INFα, INF β) inflammation reduction (mesenchyme synthesis, tissue alkalosis, sympathetic tone, antiinflammatory cytokines release: IL10, TGF β 1, etc.) Phase A can last some hours days (acute inflammation: inflammation; sub acute inflammation; inflammation plus; chronic inflammation) The duration of Phase A depends upon: 1) damage level 2) patient s immunoregulation 3) quality and quantity of the therapy

41 ENDORPHIN Endorphins are organic chemical substances produced by the CNS, having antipain and physiological characteristics similar to those of morphine and opium however they have a wider range Endorphins, like a number of morphinic origin alkaloids, can cause states of euphoria and somnolence according to the quantity released

42 Physiological Regulating Medicine in Pain Management Homeopathic microdoses: guarantee lack of negative side effects avoid troubles concerning tolerance avoid pharmacological catabolites overload in extracellular matrix and organs

43 ANATOMICAL STRUCTURE OF AN ACUPOINT 43

44 GUNA -NECK Clinical Indications Neck pain due to cartilage degenerative cervical spine disorders (cervical osteoarthrosis) Neck pain due to cervical muscular trigger points Stiff neck syndrome Simple neck pain Whiplash Postural neck ache Mechanical imbalance (facet joint syndrome) Cervical spinal ligament syndrome Cervical spinal nerve root pain Arnold syndrome 44

45 Active ingredients: Cartilago suis 4X HPUS 4 parts; Anti interleukin 1 alpha 4C, Anti interleukin 1 beta 4C, Beta-Endorphin 4C, Magnesia phosphorica 8X HPUS, Nux vomica 10X HPUS, Picricum acidum 10X HPUS, Silicea 4X HPUS 2 parts; Crotalus horridus 10X HPUS, Intervertebral disk, Porcine 4X 1 part. Inactive ingredient: Sterile isotonic sodium chloride solution. 45

46 GUNA -NECK Beta-Endorphin 4C Pain Riduzione symptomatology della sintomatologia reduction by means of algica UP-REGULATION per UP-REGULATION of β Endorphin dei receptors recettori della β Endorfina Stimulation of osteoblasts function and correction of articular structure pathologies P.N.E.I. antalgic core Magnesia phosphorica 12X Picricum ac. 8X Crotalus horridus 10X Nux vomica 10X Homeopathic antalgic core Anti- Anti- degenerative inflammatory core 2 core Anti- degenerative core 1 Reduction of cervical rachis pain symptomatology of different origin: Fibromyalgic origin (Picricum acidum) Spastic and/or congestive origin (Crotalus horr., Nux vomica, Magnesia phosph.) Nevralgic origin (Magnesia phosph.) Anaesthetic origin: Picricum acidum Silicea 4X Anti interleukin 1 alpha 4C Anti interleukin 1 beta 4C Biostimulation cartilage matrix components synthesis (Cartilago) Anti-degenerative action (Discus intervertebralis) Cartilago suis 4X Intervertebral disk, Porcine 4X Modulation of IL1 α and IL1 β pro-inflammatory activity in the trigger phase of inflammation 46

47 Most common combinations: Guna Neck + Guna Muscle: neck pain due to cervical trigger points, muscle tensive occipital frontal headache, whiplash. Guna Neck + Guna Neural: brachialgia from cervical arthrosis, cranic neuritis caused by atlo epistrophic dislocation, muscle tensive headache, lost of physiological cervical lordosis. Guna Neck + Guna Polyarthritis: cervical syndrome caused by rheumatoid osteoarthritis or other autoimmune diseases, cervical syndrome caused by general somatic pain. Guna Neck + Guna Arthro: cervical arthrosis, cervical articular discomfort. Guna Neck + Guna Trauma: post surgery recovery, cervical contusions in traumatology and sport medicine. 47

48 GUNA -NECK into specific and selected local Acupuncture Points GB 21 GV 16 GB 20 BL 10 GV 15 GB 21 SI 10 SI 9 GV 14 48

49 GUNA -NECK into Trigger Points and referred pain zones TP SI 15 BL 10 TP/SI 14 C 7 BL 11 TP C 7 TP = Main Trigger Points and correlated Acupuncture points 49

50 Treatment Standard protocol for i.m. administration: 1 ampoule 1-3 times a week according to severity and clinical evolution. Standard protocol according to mesotherapeutic technique using 1-2 ampoules per treatment: 2 treatments for the first 2 weeks, 1 treatment a week till pain relief (average 8-10 sessions). For chronic pathologies: continue 1 treatment a week for 1 month till pain relief, then 1 treatment a month. 50

51 Type of needle Select application site according to acupuncture points, trigger points, tender points, referred pain zones, nerve key points, Head zones or local pain points. Using a 13 mm 30G, a 4 mm 27G, or an insulin needle, make the classic intradermal or subcutaneous injection according to mesotherapic technique. 51

52 GUNA -THORACIC Clinical Indications Thoracic pain due to cartilage degenerative thoracic spine disorders (thoracic osteoarthrosis) Thoracic pain due to scoliosis Thoracic pain due to thoracic long muscle trigger points Pain due to thoracic spine osteophytosis Simple posterior thoracic pain (thoracic pain syndrome) Mechanical imbalance (costo-vertebral facet joint syndrome) Thoracic spinal ligament syndrome Thoracic spinal nerve root pain Pain from spinal osteoporosis 52

53 Active ingredients: Chininum sulphuricum 8X HPUS 4 parts; Anti interleukin 1 alpha 4C, Anti interleukin 1 beta 4C, Beta-Endorphin 4C, Calcarea phosphorica 6X HPUS, Cimicifuga racemosa 4X HPUS, Intervertebral disk, Porcine 4X, Spongia tosta 10X HPUS 2 parts; Chelidonium majus 4X HPUS, Conium maculatum 6X HPUS 1 part. Inactive ingredient: Sterile isotonic sodium chloride solution. 53

54 GUNA -THORACIC Beta-Endorphin 4C Pain Riduzione symptomatology della sintomatologia reduction by means of algica UP-REGULATION per UP-REGULATION of β Endorphin dei receptors recettori della β Endorfina Constitutional correction of articular structure pathologies P.N.E.I. antalgic core Chelidonium majus 4X Cimicifuga racemosa 4X Conium maculatum 6X Chininum sulphuricum 8X Spongia tosta 10X Homeopathic antalgic core Anti- Constitutional core inflammatory core Anti- degenerative core Reduction of the dorsal rachis pain symptomatology of different origin, type and localization: Neuro-muscular origin(cimicifuga, Chininum sulph., Conium) Spastic and/or congestive origin(chelidonium, Spongia) LOCALIZATION Dorsal rachis: direct, all; hepatic reflex, Chelidonium. Intercostal pain: Spongia Calcarea phosphorica 6X Anti interleukin 1 alpha 4C Anti interleukin 1 beta 4C Anti-degenerative and antineuralgic action Intervertebral disk, Porcine 4X Modulation of IL1 α and IL1 β pro-inflammatory activity in the trigger phase of inflammation 54

55 Most common combinations: Guna Thoracic + Guna Muscle: thoracic pain due to scoliosis and thoracic long muscle trigger points, pain of the deep paravertebral thoracic muscles. Guna Thoracic + Guna Neural: intercostal pain, post herpetic thoracic neuritis, thoracic spinal nerve root pain. Guna Thoracic + Guna Polyarthritis: thoracic syndrome caused by rheumatoid osteoarthritis, general thoracic pain. Guna Thoracic + Osteobios TM : thoracic vertebral fractures, thoracic vertebral slow healing. Guna Thoracic + Guna Arthro: general thoracic osteoarthrosis. 55

56 GUNA -THORACIC into specific local Acupuncture Points BL 42 SI 10 GB 20 BL 10 BL 41 BL 11 BL 12 BL 13 BL 14 BL 15 BL 16 BL 17 Ex Yishu Selected according to the most painful area (max 10 points each treatment) BL 18 BL 19 BL 20 BL 21 GB 30 56

57 Treatment Standard protocol for i.m. administration: 1 ampoule 1-3 times a week according to severity and clinical evolution. Standard protocol according to mesotherapeutic technique using 1-2 ampoules per treatment: 2 treatments for the first 2 weeks, 1 treatment a week till pain relief (average 8-10 sessions). For chronic pathologies: continue 1 treatment a week for 1 month till pain relief, then 1 treatment a month. 57

58 Type of needle Select application site according to acupuncture points, trigger points, tender points, referred pain zones, nerve key points, Head zones or local pain points. Using a 13 mm 30G, a 4 mm 27G, or an insulin needle, make the classic intradermal or subcutaneous injection according to mesotherapic technique. 58

59 GUNA -LUMBAR Clinical Indications Lumbar pain due to cartilage degenerative lumbar spine disorders (lumbar and lumbar-sacral arthrosis) Lumbar vertebral osteophytosis Low back pain due to muscular and tendinous trigger points Simple lumbar pain (low back syndrome) Weak low back syndrome Postural low back ache Lumbar and lumbar-sacral mechanical imbalance Lumbar and lumbar-sacral spinal ligament syndrome Sacro-iliac syndrome Spinal lumbar and lumbar-sacral nerve root pain 59

60 Active ingredients: Alumina 8X HPUS 4 parts; Anti interleukin 1 alpha 4C, Beta-Endorphin 4C, Bryonia alba 4X HPUS, Hamamelis virginiana 6X HPUS, Natrum sulphuricum 8X HPUS, Phosphoricum acidum 6X HPUS, Sepia 4X HPUS 2 parts; Anti interleukin 1 beta 4C, Intervertebral disk, Porcine 4X 1 part. Inactive ingredient: Sterile isotonic sodium chloride solution. 60

61 Reduction of the lumbar rachis pain symptomatology of different origin, type and localization: Neuro-muscular origin (Bryonia, Alumina, Ac. Phosphoricum). Articular origin (Natrium sulph.) Beta-Endorphin 4C GUNA -LUMBAR Type cramp-like pain (Ac. phosphoricum); muscular paresis phenomena (Alumina) Localization Lumbosacral rachis: direct, Hamamelis; abdominal reflex, Sepia P.N.E.I. Antalgic core Pain symptomatology reduction by means of UP- REGULATION of β Endorphin receptors Homeopathic antalgic core Anti- inflammatory core Anti interleukin 1 alpha 4C Bryonia 4X Sepia officinalis 4X Phosphoricum ac. 6X Hamamelis virginiana 6X Alumina 8X Natrum sulphuricum 8X Anti-degenerative and antineuralgic action Anti-degenerative core Intervertebral disk, Porcine 4X Anti interleukin 1 beta 4C Modulation of IL1 α and IL1 β pro-inflammatory activity in the trigger phase of inflammation 61

62 Most common combinations: Guna Lumbar + Guna Muscle: low back pain due to muscular and tendineous trigger points, low back pain caused by strain from prolonged stay in erect position, lumbago caused by sports training. Guna Lumbar + Guna Ischial: sacroiliac syndrome, leg neuritis, sciatic neuralgia. Guna Lumbar + Guna Neural: low back pain, lumbar neuritis with projected pain to the lower thoracic side. Guna Lumbar + Guna Polyarthritis: general lumbar arthrosis, sacroiliac syndrome caused by rheumatoid arthritis. Guna Lumbar + Guna Arthro: lumbar arthrosis, lumbar articular discomfort. Guna Lumbar + Guna Lympho: pre and post surgery recovery of a disc hernia L4 L5, L5 S1. 62

63 GUNA -LUMBAR into specific local Acupuncture Points Selected according to the most painful area (max 10 points each treatment) Ex Shiqizhuixia GV 4 BL 52 Ex Yaoyan BL 31 BL 32 BL 53 BL 33 GV 2 BL 23 BL 24 BL 25 BL 26 BL 27 BL 28 BL 29 BL 30 Ex Huanzhong BL 54 BL 34 GB 30 BL 36 BL 35 63

64 Treatment Standard protocol for i.m. administration: 1 ampoule 1-3 times a week according to severity and clinical evolution. Standard protocol according to mesotherapeutic technique using 1-2 ampoules per treatment: 2 treatments for the first 2 weeks, 1 treatment a week till pain relief (average 8-10 sessions). For chronic pathologies: continue 1 treatment a week for 1 month till pain relief, then 1 treatment a month. 64

65 Type of needle Select application site according to acupuncture points, trigger points, tender points, referred pain zones, nerve key points, Head zones or local pain points. Using a 13 mm 30G, a 4 mm 27G, or an insulin needle, make the classic intradermal or subcutaneous injection according to mesotherapic technique. 65

66 GUNA -ISCHIAL Clinical Indications Sciatica pain Lumbar-sciatic pain Nerve pain in the lower lumbar spine Leg nerve pain due to post-surgery treatment of disk herniation L4-L5, L5-S1 Morton neuroma 66

67 Active ingredients: Aconitum napellus 8X HPUS, Anti interleukin 1 alpha 4C, Anti interleukin 1 beta 4C, Arsenicum album 6X HPUS, Beta-Endorphin 4C, Cimicifuga racemosa 4X HPUS, Gnaphalium polycephalum 4X HPUS, Lachesis mutus 8X HPUS, Rhododendron chrysanthum 6X HPUS, Rhus toxicodendron 4X HPUS 2 parts. Inactive ingredient: Sterile isotonic sodium chloride solution. 67

68 GUNA -ISCHIAL Anti interleukin 1 alpha 4C Beta-Endorphin 4C Anti interleunin 1 beta 4C Pain symptomatology reduction by means of UP-REGULATION of β Endorphin receptors P.N.E.I. antalgic core Anti- inflammatory core Modulation of IL1 α and IL1 β pro-inflammatory activity in the trigger phase of inflammation Modulation of abdominal wall reflexed sciatic pain (Lachesis) and iliac-sacral lumbar pain (Cimicifuga) Cimicifuga 4X Lachesis mutus 8X Pain modulation by means of a reduction in the progression of osteochondrosis (Cimicifuga), coxo-femoral arthrosis(rhus tox.), backache (Rhus tox). Reflexed Primary neuralgic neuralgic pain pain Secondary neuralgic pain Cimicifuga 4X Rhus toxicodendron 4X Lachesis mutus 8X Gnaphalium polycephalum 4X Arsenicum album 6X Rhododendron chrysantum 6X Aconitum napellus 8X Modulation of sciatic pain by means of inflammation neurogen phase inhibition (Aconitum and Arsenicum) and direct action on the sciatic nerve (Gnaphalium) 68

69 Most common combinations: Guna Ischial + Guna Lumbar: Sacroiliac syndrome, leg neuritis, sciatic neuralgia. Guna Ischial + Guna Neural: Leg neuritis and sciatic neuralgia in hyper acute phase. Guna Ischial + Guna Flam: decongesting action of the leg nerves, especially at the level of the vasa nervorum. 69

70 GUNA -ISCHIAL GB 30 into specific and selected local Acupuncture Points BL 36 BL 37 BL 40 BL 39 BL 57 BL 58 BL 60 70

71 Treatment Standard protocol for i.m. administration: 1 ampoule 1-3 times a week according to severity and clinical evolution. Standard protocol according to mesotherapeutic technique using 1-2 ampoules per treatment: 2 treatments for the first 2 weeks, 1 treatment a week till pain relief (average 8-10 sessions). For chronic pathologies: continue 1 treatment a week for 1 month till pain relief, then 1 treatment a month. 71

72 Type of needle Select application site according to acupuncture points, trigger points, tender points, referred pain zones, nerve key points, Head zones or local pain points. Using a 13 mm 30G, a 4 mm 27G, or an insulin needle, make the classic intradermal or subcutaneous injection according to mesotherapic technique. 72

73 GUNA -SHOULDER Clinical Indications Scapular-humeral peri-arthritis Shoulder pain Shoulder-arm syndrome Frozen shoulder Shoulder pain due to dislocation, therapeutic rest Epicondylitis 73

74 Active ingredients: Argentum nitricum 8X HPUS 4 parts; Anti interleukin 1 alpha 4C, Anti interleukin 1 beta 4C, Beta-Endorphin 4C, Cartilago suis 4X HPUS, Ferrum phosphoricum 8X HPUS, Sanguinaria canadensis 8X HPUS, Tendon, Porcine 6X 2 parts; Iris versicolor 8X HPUS, Ranunculus bulbosus 10X HPUS 1 part. Inactive ingredient: Sterile isotonic sodium chloride solution. 74

75 Reduction of shoulder pain of different origin and type: Neuralgic origin (Argentum nitricum, Ferrum phosph., Iris) Muscular origin (Ranunculus, Sanguinaria) GUNA -SHOULDER Beta-Endorphin 4C Acute pain (Ferrum, Iris) Chronic pain (Argentum nitricum, Ranunculus) P.N.E.I. antalgic core Pain symptomatology reduction by means of UP- REGULATION of β Endorphin receptors Argentum nitricum 8X Ferrum phosphoricum 8X Iris versicolor 8X Sanguinaria canadensis 8X Ranunculus bulbosus 10X Anti-degenerative and chronic antiinflammatory action (Tendon, Porcine) Homeopathic Anti- antalgic core inflammatory core Anti- degenerative core Cartilago suis 4X Tendon, Porcine 6X Anti interleukin 1 alpha 4C Anti interleukin 1 beta 4C Modulation of IL1 α and IL1 β pro-inflammatory activity in the trigger phase of inflammation 75

76 Most common combinations: Guna Shoulder + Guna Polyarthritis: scapulohumeral syndrome caused by rheumatoid arthritis or other autoimmune diseases, scapulohumeral periarthritis caused by excessive articular use. Guna Shoulder + Guna Muscle: scapulohumeral syndrome by muscle and tendon trigger points of the supraspinatus muscle (80% of the cases), para scapular muscles and trapezius. Guna Shoulder + Guna Neural: epicondylitis, referred pain of the scapulohumeral syndrome along the arm and in the muscle districts nearby. Guna Shoulder + Guna Trauma: shoulder pain due to dislocation or traumatism. Guna Shoulder + Guna Flam: frozen shoulder, scapulohumeral periarthritis in hyper acute phase. 76

77 GUNA -SHOULDER Shoulder into specific and selected local Acupuncture Points LI 16 Ex Jianzhong LI 15 LU 2 Ex Jianneiling Ex Jianquian LI 14 GB 21 GB 20 GV 16 BL 10 LI 11 LI 16 GV 14 TE 14 SI 10 SI 12 SI 11 SI 9 TE 13 LI 14 77

78 GUNA -SHOULDER into Trigger Points TP/TE 14 TP/SI 13 TP/SI 12 and referred pain zones BL 43 Shoulder TP SI 11 D 4 TP TP/SI 10 TP/SI 9 TP/Ex Jianneiling TP = Main Trigger Points and correlated Acupuncture points 78

79 TP LU 1 TP BL 46 D 7 TP = Main Trigger Points and correlated Acupuncture points 79

80 GUNA -SHOULDER Elbow into specific and selected local Acupuncture Points LI 12 LI 11 LI 10 LI 8 TE 10 SI 8 Ex Quyahgwei SI 7 TE 5 TE 4 LU 5 HT 3 PC 3 SI 4 HT 5 HT 4 SI 7 HT 4 HT 5 SI 8 HT 3 80

81 GUNA -SHOULDER into Trigger Points and referred pain zones LU 5 Elbow TP SI 8 TP TE 9 TP = Main Trigger Points and correlated Acupuncture points 81

82 HT 3 TP Elbow PC 3 TP TP = Main Trigger Points and correlated Acupuncture points 82

83 Treatment Standard protocol for i.m. administration: 1 ampoule 1-3 times a week according to severity and clinical evolution. Standard protocol according to mesotherapeutic technique using 1-2 ampoules per treatment: 2 treatments for the first 2 weeks, 1 treatment a week till pain relief (average 8-10 sessions). For chronic pathologies: continue 1 treatment a week for 1 month till pain relief, then 1 treatment a month. 83

84 Type of needle Select application site according to acupuncture points, trigger points, tender points, referred pain zones, nerve key points, Head zones or local pain points. Using a 13 mm 30G, a 4 mm 27G, or an insulin needle, make the classic intradermal or subcutaneous injection according to mesotherapic technique. 84

85 GUNA -HANDFOOT Clinical Indications Osteoarthritis of digits pain Rhizoarthrosis of the thumb (Forestier disease) Arthrosis pain due to hammer toe Carpal-tunnel syndrome De Quervain disease Metacarpal and Metatarsal pain Morton disease Rheumatoid arthritis of hand/foot Hand/Foot tendon pain due to prolonged immobilization (tendon pain related to casts) 85

86 Active ingredients: Arnica montana 4X HPUS, Viola odorata 6X HPUS 4 parts; Anti interleukin 1 alpha 4C, Anti interleukin 1 beta 4C, Beta-Endorphin 4C, Caulophyllum thalictroides 12X HPUS 2 parts; Benzoicum acidum 6X HPUS, Cimicifuga racemosa 10X HPUS, Ledum palustre 6X HPUS, Mercurius solubilis 8X HPUS 1 part. Inactive ingredient: Sterile isotonic sodium chloride solution. 86

87 GUNA -HANDFOOT Beta-Endorphin 4C Anti interleukin 1 alpha 4C Anti interleukin 1 beta 4C Pain symptomatology reduction by means of UP-REGULATION of β Endorphin receptors P.N.E.I. antalgic core Anti- inflammatory core Modulation of IL1 α and IL1 β pro-inflammatory activity in the trigger phase of inflammation Pain modulation by means of uric acid crystals accumulation inhibition (drainage action) Gout pain Degenerative pain Inflammatory pain Arnica montana 4X Caulophillum thalictroides 12X Ledum palustre 6X Benzoicum acidum 6X Pain modulation by means of degenerative process (arthrosis type) inhibition Viola odorata 6X Mercurius solubilis 8X Cimicifuga racemosa 10X Pain modulation by means of acute inflammation phenomena vasal in particular inhibition (arthrosis type) 87

88 Most common combinations: Guna Handfoot + Guna Polyarthritis: rheumatoid arthritis and other autoimmune diseases of hands and feet. Guna Handfoot + Guna Neural: carpal tunnel syndrome, neuritis after plaster cast removal, Morton disease, general pain of hand and foot, neuritis of hand and foot. Guna Handfoot + Guna Lympho: carpal tunnel syndrome, post surgery recovery. Guna Handfoot + Guna Trauma: before and after surgical operations of hand and foot, sports contusions. 88

89 GUNA -HANDFOOT SI 5 SI 4 into specific and selected local Acupuncture Points Wrist LI 5 LI 6 TE 4 PC 6 SI 5 LU 9 HT 5 LI 5 PC 7 Ex Zhongquan SI 6 TE 5 HT 7 LI 6 89

90 SIFENG POINTS PC 8 BIS LI 1 TE 1 HT 9 SI 1 BAXIE POINTS PC 8 HT 8 LU 11 TE 2 TE 3 Ex Luozhen Hand LI 4 HT 7 LU 9 PC 7 Ex Zhongquan TE 4 PC 6 TE 5 BAXIE POINTS LI 2 LI 3 LI 4 LI 5 SI 3 SI 2 SI 1 TE 1 SI 5 SI 4 LU 10 90

91 Foot ST 41 GB 40 ST 42 GB 41 GB 42 GB 43 ST 43 LR 3 ST 44 LR 2 BAFENG BL 67 GB 44 ST 45 LR 1 SP 1 In particularly painful anatomic parts such as hands and foot digits, spray ethyl chloride for 2 3 seconds at a distance of about 20 cm before infiltrating 91

92 GUNA -HANDFOOT into specific and selected local Acupuncture Points BL 59 GB 38 GB 39 ST 41 ST 42 LR 3 Ex Bafeng 3 ST 44 ST 43 LR 2 LR 1 Foot BL 60 BL 63 BL 62 GB 40 GB 44 BL 64 GB 42 GB 43 GB 41 BL 65 BL 67 ST 45 SP 6 KI 3 KI 4 SP 1 SP 2 SP 3 KI 2 SP 5 KI 5 92

93 Treatment Standard protocol for i.m. administration: 1 ampoule 1-3 times a week according to severity and clinical evolution. Standard protocol according to mesotherapic technique using 1-2 ampoules per treatment: 2 treatments for the first 2 weeks, 1 treatment a week till pain relief (average 8-10 sessions). For chronic pathologies: continue 1 treatment a week for 1 month till pain relief, then 1 treatment a month. 93

94 Type of needle Select application site according to acupuncture points, trigger points, tender points, referred pain zones, nerve key points, Head zones or local pain points. Using a 13 mm 30G, a 4 mm 27G, or an insulin needle, make the classic intradermal or subcutaneous injection according to mesotherapic technique. 94

95 GUNA -HIP Clinical Indications Hip joint osteoarthrosis Hip joint capsule inflammation Hip joint rheumatoid arthritis Hip joint pain of muscle origin Hip joint pain of nerve origin (burning hip) Hip joint pain due to prolonged bed rest Knee osteoarthrosis 95

96 Active ingredients: Arnica montana 8X HPUS 4 parts; Anti interleukin 1 alpha 4C, Anti interleukin 1 beta 4C, Beta-Endorphin 4C, Calcarea fluorica 6X HPUS, Cartilago suis 4X HPUS, Colocynthis 8X HPUS, Rhus toxicodendron 10X HPUS 2 parts; Argentum metallicum 6X HPUS, Formicum acidum 8X HPUS 1 part. Inactive ingredient: Sterile isotonic sodium chloride solution. 96

97 GUNA -HIP Beta-Endorphin 4C Argentum metallicum 6X Arnica montana 8X Colocynthis 8X Formicum ac. 8X Rhus toxicodendron 10X Pain symptomatology reduction by means of UP-REGULATION of β Endorphin receptors Constitutional correction of articular structure pathology Calcarea fluorica 6X P.N.E.I. Homeopathic antalgic core antalgic core Anti- Constitutional inflammatory core core Anti-degenerative core Reduction of hip pain symptoms of rheumatic origin : Capsule (Formicum ac., Argentum) Tendons and ligaments (Rhus tox) Nerves (Colocynthis) Muscles (Arnica) Anti interleukin 1 alpha 4C Anti interleukin 1 beta 4C Biostimulation of cartilagineous matrix components synthesis (Cartilago) New vessels development stimulation (Argentum) Cartilago suis 4X Argentum metallicum 6X Modulation of IL1 α and IL1 β pro-inflammatory activity in the trigger phase of inflammation 97

98 Most common combinations: Guna Hip + Guna Muscle: satellite muscles involvement in case of pre arthrosis or hip and knee arthrosis. Guna Hip + Guna Neural: inguinal neuritis and neuritis affecting the upper leg, caused by hip arthrosis, burning hip, neuritis due to knee arthrosis. Guna Hip + Guna Polyarthritis: coxarthritis due to rheumatoid arthritis and other autoimmune diseases, acute coxarthritis of sportsmen. Guna Hip + Guna Arthro: hip joint osteoarthritis, hip joint capsule inflammation. Guna Hip + Guna Trauma: before and after surgical operations of the hip, pain caused by prosthesis. 98

99 GUNA -HIP into specific and selected local Acupuncture Points GB 27 GB 28 SP 12 ST 30 LR 12 BL 54 GB 30 GB 29 ST 31 LR 11 LR 10 Hip SP 11 ST 32 GB 31 GB 32 LR 8 SP 9 BL 40 GB 34 GB 27 GB 28 SP 12 ST 31 ST 30 LR 12 LR 11 LR 10 99

100 GUNA -HIP TP/GB 30 into Trigger Points and referred pain zones TP/Ex Tunzhong BL 54 GB 29 GB 30 TP Hip TP = Main Trigger Points TP/GB 33 ST 31 TP TP/SP

101 Knee 101

102 Treatment Standard protocol for i.m. administration: 1 ampoule 1-3 times a week according to severity and clinical evolution. Standard protocol according to mesotherapeutic technique using 1-2 ampoules per treatment: 2 treatments for the first 2 weeks, 1 treatment a week till pain relief (average 8-10 sessions). For chronic pathologies: continue 1 treatment a week for 1 month till pain relief, then 1 treatment a month. 102

103 Type of needle Select application site according to acupuncture points, trigger points, tender points, referred pain zones, nerve key points, Head zones or local pain points. Using a 13 mm 30G, a 4 mm 27G, or an insulin needle, make the classic intradermal or subcutaneous injection according to mesotherapic technique. 103

104 GUNA -POLYARTHRITIS Clinical Indications Small joints rheumatoid arthritis of hand and foot Costo-sternal syndrome (Tietze syndrome) Chronic polyarthritis due to auto-immune diseases (e.g. Lupus erythematosus sistemicus) Broken bone syndrome due to viral or protozoic disease Joint pain due to cancer disease (chronic leukemia, monoclonal blood diseases) 104

105 Active ingredients: Salicylicum acidum 2X HPUS 4 parts; Aconitum napellus 6X HPUS, Anti interleukin 1 alpha 4C, Anti interleukin 1 beta 4C, Beta-Endorphin 4C, Drosera 8X HPUS, Ledum palustre 8X HPUS, Viscum album 10X HPUS 2 parts; Colchicum autumnale 10X HPUS, Guaiacum 10X HPUS 1 part. Inactive ingredient: Sterile isotonic sodium chloride solution. 105

106 GUNA -POLYARTHRITIS Reduction of polyarticular pain symptomatology in acute inflammation having different localization Beta-Endorphin 4C P.N.E.I. antalgic core Pain symptomatology reduction by means of UP- REGULATION of β Endorphin receptors Salycilicum acidum 2X Aconitum 6X Drosera 8X Colchicum autumnale 10X Guaiacum 10X Acute Anti- inflammatory inflammatory pain core Chronic inflammatory pain Anti interleukin 1 alpha 4C Anti interleukin 1 beta 4C Reduction of degenerative articular pain on a chronicevolutive basis Ledum palustre 8X Viscum album 10X Modulation of IL1 α and IL1 β pro-inflammatory activity in the trigger phase of inflammation 106

107 Most common combinations: Guna Polyarthritis + Guna Handfoot: rheumatoid arthritis or other autoimmune diseases of the small joints of hand and foot, metatarsalgia, metacarpalgia. Guna Polyarthritis + Guna Neural: costosternal syndrome, in cases of presence of satellite neuritis in rheumatoid arthritis or other autoimmune diseases. Guna Polyarthritis + Guna Muscle: in cases of prevalence of muscle pain in rheumatoid arthritis or other autoimmune diseases. Guna Polyarthritis + Guna Arthro: rheumatoid arthritis, localized or systemic arthrosis, arthritis in single or several areas. 107

108 Treatment Standard protocol for i.m. administration: 1 ampoule 1-3 times a week according to severity and clinical evolution. Standard protocol according to mesotherapeutic technique using 1-2 ampoules per treatment: 2 treatments for the first 2 weeks, 1 treatment a week till pain relief (average 8-10 sessions). For chronic pathologies: continue 1 treatment a week for 1 month till pain relief, then 1 treatment a month. 108

109 Type of needle Select application site according to acupuncture points, trigger points, tender points, referred pain zones, nerve key points, Head zones or local pain points. Using a 13 mm 30G, a 4 mm 27G, or an insulin needle, make the classic intradermal or subcutaneous injection according to mesotherapic technique. 109

110 GUNA -MUSCLE Clinical Indications Trigger points management: acute, subacute, chronic Fibromyalgia syndrome Referred somatic pain area management Dermatomyositis 110

111 Active ingredients: Arnica montana 4X HPUS, Colocynthis 4X HPUS 4 parts; Belladonna 6X HPUS, Lithium benzoicum 8X HPUS, Muscle tissue, Porcine 4C, Procaine chloride 2X 2 parts; Colchicum autumnale 6X HPUS, Cuprum sulphuricum 4X HPUS, Hypericum perforatum 4X HPUS, Interferon gamma 4C 1 part. Inactive ingredient: Sterile isotonic sodium chloride solution. 111

112 GUNA -MUSCLE Interferon γ 4C Procain chloride 2X Arnica montana 4X Belladonna 6X Muscle tissue, Porcine 4C Antidegenerative core Contusive pain Colchicum autumnale 6X Lithium benzoicum 8X Muscular rheumatism Spastic or cramp- like pain Sprain pain Colocynthis 4X Cuprum sulphuricum 4X Hypericum 4X 112

113 Most common combinations: Guna Muscle + Guna Neural: mostly combined for the specific action of muscle relaxation + nerve repolarization, fibromyalgia syndrome, muscle pain due to the nerve entrapment. Guna Muscle + Guna Neck: all muscle pain due to cervical syndromes. Guna Muscle + Guna Thoracic: all muscle pain due to thoracic syndromes. Guna Muscle + Guna Lumbar: all muscle pain due to low back syndromes. Guna Muscle + Guna Hip: all muscle pain due to hip or knee syndromes. Guna Muscle + Guna Shoulder: all muscle pain due to shoulder or elbow syndrome. Guna Muscle + Guna Flam: all muscle aches. 113

114 Treatment Standard protocol for i.m. administration: 1 ampoule 1-3 times a week according to severity and clinical evolution. Standard protocol according to mesotherapeutic technique using 1-2 ampoules per treatment: 2 treatments for the first 2 weeks, 1 treatment a week till pain relief (average 8-10 sessions). For chronic pathologies: continue 1 treatment a week for 1 month till pain relief, then 1 treatment a month. 114

115 Type of needle Select application site according to acupuncture points, trigger points, tender points, referred pain zones, nerve key points, Head zones or local pain points. Using a 13 mm 30G, a 4 mm 27G, or an insulin needle, make the classic intradermal or subcutaneous injection according to mesotherapic technique. 115

116 GUNA -NEURAL Clinical Indications Non-specific brachial pain Brachial nerve pain due to cervical entrapment Intercostal nerve pain due to thoracic entrapment Postherpetic neuritis Atypical facial neuritis (Slüder syndrome, Charlin syndrome) Trigeminal neuritis Pain of the temporomandibular joint (TMJ) Arnold syndrome Cervical, thoracic, lumbar and sacrolumbar nerve root pain 116

117 Active ingredients: Aconitum napellus 8X HPUS, Beta-Endorphin 4C, Colocynthis 4X HPUS, Ferrum phosphoricum 2X HPUS, Formica rufa 8X HPUS, Gnaphalium polycephalum 6X HPUS, Iris versicolor 8X HPUS, Kalmia latifolia 2X HPUS, Neurotrophin 4 4C, Paris quadrifolia 6X HPUS 2 parts. Inactive ingredient: Sterile isotonic sodium chloride solution. 117

118 GUNA -NEURAL Beta-Endorphin 4C Kalmia latifolia 2X Ferrum phosphoricum 2X Colocynthis 4X Paris quadrifolia 6X Pain symptomatology reduction by means of UP-REGULATION of β Endorphin receptors Modulation of paresis and paralysis phenomena Kalmia latifolia 2X P.N.E.I. antalgic Inflammatory core aetiology Rheumatoid Vascular aetiology aetiology Degenerative aetiology Gnaphalium polycephalum 6X Iris versicolor 8X Aconitum napellus 8X Reduction of different peripheral nerves inflammation Formica rufa 8X Trophic action on roots and nerve endings damaged because of degenerative or lesionary phenomena Neurotrophin 4 4C Reduction of pain and paraesthetic phenomena by means of hyperemetic action on nerves 118

119 Infiltration points for trigeminal pain Infiltration points for Charlin and Slüder syndromes pain 119

120 Most common combinations: Guna Neural + Guna Muscle: mostly combined for the specific action on nerve repolarization + muscle relaxation, fibromyalgia syndrome, muscle pain due to the nerve entrapment. Guna Neural + Guna Neck: all neural pain due to cervical syndromes. Guna Neural + Guna Thoracic: all neural pain due to thoracic syndromes. Guna Neural + Guna Lumbar: all neural pain due to low back syndromes. Guna Neural + Guna Hip: all neural pain due to hip or knee syndromes. Guna Neural + Guna Shoulder: all neural pain due to shoulder or elbow syndromes. Guna Neural + Guna Ischial: neuritis of the leg and sciatic neuralgia in hyperacute phase. Guna Neural + Guna Flam: all nerve aches. 120

121 Treatment Standard protocol for i.m. administration: 1 ampoule 1-3 times a week according to severity and clinical evolution. Standard protocol according to mesotherapeutic technique using 1-2 ampoules per treatment: 2 treatments for the first 2 weeks, 1 treatment a week till pain relief (average 8-10 sessions). For chronic pathologies: continue 1 treatment a week for 1 month till pain relief, then 1 treatment a month. 121

122 Type of needle Select application site according to acupuncture points, trigger points, tender points, referred pain zones, nerve key points, Head zones or local pain points. Using a 13 mm 30G, a 4 mm 27G, or an insulin needle, make the classic intradermal or subcutaneous injection according to mesotherapic technique. 122

123 BEAUTY MEDICINE Injectable 123

124 The multi injector (adiposity, cellulite) 124

125 The single needle (wrinkles therapy) 125

126 Needles 4 mm X 27G (cellulite and toning tissue) 4mm X 30G (Reumatology and wrinkles) 13 mm X 30G (wrinkles due tunneling tecnique) 126

127 127

128 Chronoaging + Photoaging Enzymatic injury Cellular metabolisms slowdown Cellular change Tissular destructuring (WRINKLE) 128

129 WRINKLES Therapeutic strategy VASCULAR REMEDIES CATALYSTS Vascularisation stimulation + Connectivum drainage + + Enzymatic activity releasing + Trophic stimulation of tissues DRAINAGE REMEDIES ORGAN PREPARATIONS SUIS 129

130 HOMEOPATHIC ENZYMES Jaluronidasi D8/D30 CLASSIC HOMEOPATIC REMEDIES Sulphur D12; Mercurius sol. Hahn. D20; Calcium fluoratum D30; Galium aparine D6; Thuja D6 Inhibition to the destructuring action of the autologous jaluronidasis Drainage and constitutional support MADE Trophic action on skin and connective tissue CATALYSTS AND OLIGOELEMENTS Vit. C D6/Vit.B1 D6/ Vit. B6 D6/Nicotinamid D6/Ac. Cis.aconit.D6/Ac.fumaricum D6/Ac. A-ketoglut. D6/Baryum oxalsucc. D6/ Natrium oxalac. D6/ Natrium Pyruv. D8/ Magnesium gluconicum D6/ Manganum phosphoricum D10 SUIS ORGAN PREPARATIONS Kollagen D8/D30; Funiculus umb. Suis D10/D30; Musculus suis D20; Placenta suis D10; Hepar suis D10; Glandula suprar. Suis D10; cutis suis D8/D30 Antioxidant and catalytic action on collagen metabolism 130

131 MADE On MADE s structure the pathogenetic process of wrinkles is inscribed Phase 1: a reduced supply of O 2 and nutrients to the dermis cells caused by the pollution of the matrix due to catabolites produced in cell turnovers (chronoaging) and by undrained toxins (free radical photoaging), causes a slowdown of intracellular metabolisms and subsequent enzymatic damage; Phase 2: the metabolic distress of the fibroblast affects its activity leading to a drastic reduction in the incretion of the matrix components (in particular Hyaluronic acid) and the collagen and elastic fibres. Phase 3: the connective tissue weave loses compactness. The lack of glycosaminoglycans has a dramatic effect on skin hydration (Hyaluronic acid is a highly hydrophilic molecule) and its turgidity; the reduced vascularisation of the epidermis causes the skin to lose its brightness and normal lymphatic drainage is slowed down, resulting in a vicious cycle that is difficult to break. 131

132 MADE PHASE 1 CONNECTIVAL DRAINAGE CORRECTION THERAPY OF THE GROUND PREDISPOSING THE WRINKLE FORMATION Drainage and costitutional support PHASE 4 STRUCTURAL INTEGRITY PROTECTION OF THE JALURONIC ACID MOLECULES Antioxidant and catalytic action on the collagen metabolism CLASSIC HOMEOPATHIC REMEDIES CATALYSTS AND OLIGOELEMENTS HOMEOPATIC ENZYMES SUIS ORGAN PREPARATIONS Inhibition to the destructuring action of the autologous jaluronidasis PHASE 2 METABOLIC UNBLOCK Proliferative, trophic and antidegenerative stimulus on skin and connective tissue PHASE 3 NEO-SYNTHESIS OF: JALURONIC AC. COLLAGEN ELASTIN 132

133 CONNECTIVE TISSUE IL TESSUTO CONNETTIVO 114 HOMEOPATHIC HYALURONIDASE INTERMEDIATE CATALYSTS AND OLIGO ELEMENTS ORGAN PREPARATIONS SUIS CLASSIC HOMEOPATHY REMEDIES Target sites of MADE components 133

134 MADE For more than five years the homeopathic remedy MADE (manufactured by Guna, Milan ITALY) has been an extremely effective alternative to conventional pharmacological treatment. The connective tissue is not the main target area in the treatment of wrinkles and skin slackening; in fact, it is essential to keep the dermis well-drained and metabolically efficient in order to keep the skin looking young. MADE is therefore a true therapeutic unit whose structure provides the correct homotoxicological strategy for treating degenerative skin diseases. 134

135 MADE A wrinkle treatment should be an integrated therapy where fibroblasts can begin their synthesizing activity (after specific organ preparation stimulation) as their proper metabolic function has returned as a result of the action of the coenzyme substrates of the Krebs cycle and they, therefore, have sufficient energy levels to maintain their neosynthesis activity. At the same time, the integrity of the functional structure of the dermis should be maintained by means of continuous detoxification and drainage. 135

136 FIBROBLAST NEO SYNTHESIS OF AUTOLOGOUS COLLAGEN Anabolic stimulation of the fibroblast Therapeutic success COLLAGEN D6 136

137 FACE BIO LIFTING 1 ampoule 2ml MADE + 1 ampoule 2ml GUNA COLLAGEN 0,3 ml per point subcutaneous application Week: 2, 5, 6 137

138 FACE AND ANTERIOR NECK BIO LIFTING 138

139 Infiltration points 139

140 NECK BIO LIFTING 140

141 MAIN ACUPOINTS FOR FACE BIO- LIFTING 1 GALL BLADDER (1VB) 14 GALL BLADDER (14VB) 14 vb 21 tr 21 TRIPLE HEATER (21TR) 4e 4 STOMACH (4 ) 141

142 It s a method involving the decollement of tissues triggering a small inflammatory reaction and leading to disappearance of wrinkles TUNNELING 142

143 SERUM VITAE Topic treatment of wrinkles and skin slakening Stimulation of the synthesis of the fibroblastic autologous collagen. Cell energy optimization by stimulation of the transacetilation of the Pyruvic acid: biochemical key to the Krebs cycle. Coenzyme A Collagen SQUALENE Embryo extract Stimulation of the synthesis of the matrix structural components. Stimulation of the vascularization. Antidegenerative action. Anti free radicals action on skin level. Anti-aging action Dipartimento Scientifico Guna S.p.a.

144 ANTI AGE SKIN (ANTI AGE CUT) Stimulation of skin function Rehydration, remineralization, disintoxication and drainage; recovery of the cutaneous elasticity. Ascophyllum nodosum CH Fucus vesiculosus 4CH Fucus serratus 4CH Fucus platycarpus 4CH Laminaria 4CH Ulva lactuga 4CH Anabolic and anticatabolic action. Cutis 4CH Placenta suis 4CH T. capillaris 4CH Collagen suis 4CH TROPHIC ACTION ANTIAGING ANTIOXIDATIVE ACTION ACTION PROTEINS NEO- SYNTHESIS Leucina 4CH Isoleucina 4CH Trophic stimulation of the skin. Stimulation of the vascularization. Neo- synthesis of the autologous collagen. Vitamina E 4CH Vitamina A 4CH Selenium met. 4CH Ubichinon 4CH Inhibition of the free radicals accumulation and of the cutaneous photo-aging. Stimulation of the cell respiration Dipartimento Scientifico Guna S.p.a.

145 BEFORE Courtesy of Dr.ssa N. Frasca AFTER 145

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158 HANDS BIO LIFTING 158

159 159

160 Calcium fluoratum D 10/30/200 Carduus marianus D 6 Fucus vesiculosus D10/30/200 Sarsaparilla D 6 Sulfur D 12 OMEOFORMULA 1 Classic homeopatic remedies Catalysts Nosodes Suis organ preparations Adeps suillus D 10 Arteria suis D 6 Glandula thyreoidea suis D 10 Hypophysis suis D 10/30/200 Dipartimento Scientifico Guna S.p.a. Ac. α-chetoglutaricum D 6 Baryum oxalsuccinicum D6 Ac. cis-aconiticum D 6 Ac. citricum D 6 Ac. fumaricum D 6 Ac. DL-malicum D 6 Ac. succinicum D 6 Magnesium gluconicum D 6 Manganum phosphoricum D 6 Natrium oxalaceticum D 6 Natrium pyruvicum D 6 Nicotinamid D 6 - Adiposity 2 ml Ampoules- 50 Ampoules packing 160

161 161

162 162

163 OMEOFORMULA 1 8 INCREASE OF CATABOLIC ACTIVITY AT LIVER LEVEL AND EXCRETORY AT KIDNEY LEVEL CARDUUS MARIANUS SARSAPARILLA 7 CENTRIFUGATION OF TOXINS MADE FLOW FROM THE ADIPOCITE INTO THE MATRIX SULFUR 1 INCREASE OF CEL OXIDATIVE PROCESSES FUCUS VESICOLOSUS Hypertrophic Adipocite 2 STIMULATION OF HORMONAL KINETICS (THYROID AND HYPOPHISIS) GLANDULA THYREOIDEA SUIS HYPOPHISIS SUIS 3 STIMULATION OF SPECIFIC IMMUNE RESPONSE AGAINST ADIPICITE ADEPS SUILLUS 6 CONTRAST TO TISSUES SLACKENING CALCIUM FLUORATUM 5 INCREASE OF BLOOD FLOW ARTERIA SUIS 4 METABOLIC SUPPORT TO TRIGLICERIDES HYDROLISIS PROCESSES CATALIZZATORI DEL CICLO DI KREBS 163

164 164

165 ADIPOSITY: MAIN ACUPUNCTURE POINTS Gall bladder 23: In the 4 intercostal space, 4 intervals inferiorly to the anterior axillary crease 165

166 ADIPOSITY: MAIN ACUPUNCTURE POINTS Stomach 37: 3 cm inferiorly to the nearest point of intersection between the tibia and fibula, 2 cm lateral to the anterior tibial crest Stomach 40: In the middle third of the anterolateral surface of the leg Stomach 44: 0,5 cm posteriorly to the edge of the interdigital membrane between the 2 and 3 digit, in the humeral epycondyle, with the elbow flexed 166

167 ADIPOSITY: MAIN ACUPUNCTURE POINTS Large intestine 11: In the middle third between the lateral extremity of the plica transversa of the elbow and the humeral epicondyle, with the elbow flexed 167

168 Aranea diadema D 10 Calcium sulfuricum D 6/30/200 Calcium phosphoric. D 6/30/200 Echinacea angustifolia D 10 Graphites D 10 Hamamelis D 10 Myosotis arvensis D 6 Natrium sulfuricum D 6 Scrofularia nodosa D 6 Juglans regia D 6 OMEOFORMULA 2 Classic homeopatic remedies Ac. α-chetoglutaricum D 6 Baryum oxalsuccinicum D6 Ac. cis-aconiticum D 6 Ac. citricum D 6 Ac. fumaricum D 6 Ac. DL-malicum D 6 Ac. succinicum D 6 Catalysts Suis organ preparations Magnesium gluconicum D 6 Manganum phosphoricum D 6 Natrium pyruvicum D 6 Nicotinamid D 6 AMPc D 6 Cellulite 2 ml Ampoules- 50 Ampoules packing Vena suis D 10 Vasa lymphatica suis D 6 168

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172 172

173 NORMALITY Interadiposity interstice Adipocytes Capillary Nucleus Reticulum of pre-collagen reticular fibrils 173

174 PATHOLOGIC ASPECTS 1ST STAGE Initial adipocytes change Interstices broadening PATHOLOGIC ASPECTS 2ND STAGE Vascularization change Collagen fibrils differing from reticular fibrils Ectasy, microaneurysms of capillaries Edematous transudate caused by an exaggerated increase of venular capillary permeability Pre-collagen reticular fibrils during the hyperplastic hypertrophic phase 174

175 HARD CELLULITE 175

176 MILD CELLULITE 176

177 SOFT CELLULITE. 177

178 SOFT CELLULITE 178

179 CELLULITE: MAIN ACUPUNCTURE POINTS MAIN ACUPOINTS 179

180 CELLULITE: MAIN ACUPUNCTURE POINTS 6 SPLEEN PANCREAS PANCREAS 3 cm superiorly to the apex of the medial malleolus, behind the posterior edge of the tibia 180

181 CELLULITE: MAIN ACUPUNCTURE POINTS In the depression of the medial tibial condyle, below its tuberosity 9 SPLEEN PANCREAS PANCREAS 181

182 CELLULITE: MAIN ACUPUNCTURE POINTS 10 SPLEEN PANCREAS PANCREAS On the internal surface of the tigh, posterior border of the sartorius, 3 digits transversal superiorly to the posterosuperior corner of the medial condyle of the femur 182

183 CELLULITE: MAIN ACUPUNCTURE POINTS 60 URINARY BLADDER At the level of the apex of the external malleolus, between this one and the heel bone tendon 183

184 CELLULITE: MAIN ACUPUNCTURE POINTS In the middle between the medial malleolus and the the heel bone tendon 3 KIDNEY 184

185 CELLULITE: MAIN ACUPUNCTURE POINTS In the inguinal crease, laterally to the femoral artery 11 LIVER 185

186 CELLULITE: ANTERIOR SYMPTOMATIC POINTS 186

187 CELLULITE: POSTERIOR SYMPTOMATIC POINTS 187

188 CELLULITE: LATERAL SYMPTOMATIC POINTS 188

189 ANTI AGE VEIN Stimulation of peripheric blood circulation Decrease of the phlogosis vascular manifestations. Ananassa sativa D3 Mercurius sol. D10 Pulsatilla D10 Aconitum D10 Arnica D10 Belladonna D10 Stimulation of the lymph circulation. Improvement of the venous backflow. Arteria suis 4CH Vena suis 4CH Vasa lymphatica 7CH Arsenicum alb. D12 China D10 Ferrum met.d10 Viscum album D3 Calcium fluoratum D8 STIMULATION OF THE VASCULAR FUNCTION ANTI-INFLAMMATORY INFLAMMATORY AND ANTI- DEGENERATIVE ACTION LYMPHO- HEMATIC DRAINAGE Hamamelis D3 Vaccinium vitis D3 Centella asiatica D3 Ananassa sativa D3 Apis D10 PHLEBOTONIC ACTION Recovery of the function of arteries, veins, lymph vessels. Antidegenerative action. Aesculus D3 Calcium fluoratum D8 Hamamelis D3 Lachesis D10 Pulsatilla D10 Arnica D10 Improvement of the venous wall tonus. Stabilization of the vascular permeability Dipartimento Scientifico Guna S.p.a.

190 Calcium carbonicum D 10/30/200 Cyclamen D 6 Natrium sulfuricum D 6 Pulsatilla D 6 Thuja D 6 OMEOFORMULA 3 Classic homeopatic remedies Ac. α-chetoglutaricum D 6 Baryum oxalsuccinicum D6 Ac. cis-aconiticum D 6 Ac. citricum D 6 Ac. fumaricum D 6 Ac. DL-malicum D 6 Ac. succinicum D 6 Catalysts Food supplements Suis organ preparations Magnesium gluconicum D 6 Manganum phosphoricum D 6 Natrium pyruvicum D 6 Nicotinamid D 6 Tissue tone treatment 2 ml Ampoules- 50 Ampoules packing MAP Master aminoacid pattern D 6 Embryo tot. suis D 6 Funiculus umbilicalis suis D 6 Placenta suis D

191 191

192 192

193 193

194 GLUTEUS TONING 194

195 OMEOFORMULA 4 MAGNESIUM PHOSPH. D10 ACIDUM CIS ACONITUM D10 ATP D10 NAD D10 INTERMEDIATE CATALYSTS SUIS ORGAN PREPARATIONS CLASSIC HOMEOPATHIC REMEDIES PULSATILLA D4 SENECIO VULGARIS D Guna S.p.a. Scientific Department HYPOPHYSYSIS SUIS D6/D30 CUTIS SUIS D6 UTERUS SUIS D6 EMBRYO TOTALIS SUIS D6 MAMMA SUIS D6/D30 - Breast firming treatment - 2 ml Ampoules - 50 Ampoules packing 195

196 OMEOFORMULA 4 BREAST TONING Therapeutic startegy 3 points of attack Pulsatilla Embryo totalis suis Cutis suis HISTOLOGICAL ENDOCRINE + STIMULATION MODULATION + METABOLIC SUPPORT Senecio vulgaris Hypophysis suis Mamma suis Uterus suis Krebs Cycle catalysts Oligo elements 2004 Guna S.p.a. Scientific Department 196

197 OMEOFORMULA 4 1 SUPPORT OF THE METABOLIC FUNCTIONS OF THE CELLS MAGNESIUM PHOSPH. D10 ATP D10 NAD D10 ACIDUM CIS ACONITUM D10 5 FIRMING AND TONING ACTION DUE TO CUTANEOUS MATABOLISMS STIMULATION CUTIS SUIS D6 HYPOTROPHIC HYPOTONIC BREAST 2 ENDOCRINE NETWORK REGULATION HYPOPHYSIS SUIS D6/D30 UTERUS SUIS D6 PULSATILLA D4 SENECIO VULGARIS D4 4 FIRMING AND TONING ACTION DUE TO MAMMARY GLAND METABOLISM STIMULATION MAMMA SUIS D6/D30 3 FIRMING AND TONING ACTION DUE TO VASCULARIZATION IMPROVEMENT AND PROTEIN SYNTHESIS STIMULATION EMBRYO TOTALIS SUIS Guna S.p.a. Scientific Department

198 MAMMARY GLAND OMEOFORMULA 4 Therapeutic result Mammary gland anabolic stimulation. Glandular function stimulation by means of immunologic mechanisms. VOLUME INCREASE Mamma suis D6/D Guna S.p.a. Scientific Department

199 HYPOPHYSIS HYPOPHYSEAL HORMONS OMEOFORMULA 4 PHYSIOLOGICAL INCRECTION RECOVERY Glandular function stimulation by means of immunologic mechanisms. GLAND Risultato terapeutico TSH Hypophysis suis FSH GH ACTH D6/D30 LH PRL Guna S.p.a. Scientific Department

200 OMEOFORMULA 4 PROLACTIN RECEPTORS + PULSATILLA D4 Pulsatilla D4, contained in Omeoformula 4, boosts PRL receptors activity. The contemporaneous action of Hypophysis suis D6/D30, improving the hypophysial action through a PRL increction increase, with Mamma suis D6/D30, having a carrier action, brings to an optimal mammary gland stimulation. Uterus suis D6 stimulates uterus endocrine function by means of an increase in the estrogenic activity. Senecio vulgaris D4, in the end, regulates the whole endocrinologic network Guna S.p.a. Scientific Department

201 POINTS TO BE TREATED The 4 quadrants of breast have to be infiltrated 201

202 202

203 203

204 BEAUTY MEDICINE Home therapy 204

205 GUNA PROTOCOL FOR HOME THERAPY ASSOCIATED WITH THE HOMEO MESOTHERAPY TREATMENT IN AESTHETIC MEDICINE (8 10 SESSIONS) HOME ORAL DRAINAGE THERAPY FOR ABOUT 2 MONTHS: GUNA MATRIX 10 DROPS 3 TIMES A DAY GUNA LYMPHO 10 DROPS 3 TIMES A DAY GUNA DIUR* 10 DROPS 3 TIMES A DAY *Only for treatments of Localized Adiposity and Cellulite ALL THE A.M. PRODUCTS CAN BE TAKEN TOGETHER (for example putting drops of each medicine in 1 litre bottle of water. The patient drinks this bottle during the whole day) AFTER EACH SESSION, APPLY TAMANU ARNICA CREAM ON THE SKIN INJECTION SITES TO REDUCE THE POSSIBLE INFLAMMATORY EFFECT DUE TO THE INJECTION. 205

206 Deactivation (through inflammation) and neutralization of the impregnation toxins*. Pyrogenium 12X* Fucus 3X* Tyrosine 2X** Phenilalanine 2X** Histidine 2X** Synergic action with Fucus of the thyroid hormons activating the sympatheticotonic nervous system**. Hyaluronidase 6X* Thuja 6/8/12/30/200X** Natrium sulfuricum 6/8/12/30/200X ** Prolactine 6X*** DHEA 6X*** Matrix hydrolysis* Action against the constitutional proneness to a matrix impregnation and to the development of a Dysmetabolic Mesenchymopathy (Sycosis).** Matrix solubilization.*** GUNA-MATRIX Toxins neutralization Action against toxin impregnation Metabolic support Lymphatic drainage Lymphatic vessel 6X Matrix drainage Inactive toxins canalization towards the lymphatic circle for the drainage Ac. D-L malicum 6X* Natrium oxal. 6X* Natrium pyruv. 6X* NADID 6X* Trychinoil 6X* Vit. C 2X* Ac. L(+) lacticum3x** Stimulation of the energetic mitochondrial activity.* Matrix acidification (promoting the connective reactivity).** IL 6 4C* DHEA 6X* Pyrogenium 12X* Conjunctive Tissue 6X* Tyrosine 2X** Phenilalanine 2X** Histidine 2X** Prolactine 6X*** Increase of the Fundamental Substance cynetics (protein hydrolysis, hyper-ionicity, histaminic activity, > temperature) and of the matrix turnover.* Sympatheticotonic stimulation.** 206 Vagotonic slowdown.***

207 GUNA-LYMPHO Reduction of the local phlogosis on the lymphoepithelial tissues. Reduction of the lymphatic spasm on inflammatory basis with following restoration of the lymphatic circulation. Calendula 1X Phytolacca 3X Apis 8X Magnesia phosph. Humoral immunity stimulation and inhibitory modulation of the excessive cell mediated compensatory response Myosotis 3X Equisetum 3X Hydrocotile 1X Taraxacum 1X Sarsaparilla 3X Lymphatic vessel 6X Capillary tisssue 6X L-Thyroxin 6/12X Vein porcine 6X REACTIVATION OF THE LYMPHATIC CIRCULATION ANTI-INFLAMMATORY ACTIVITY ON THE LYMPHOEPITELIAL TISSUES HYPERTROPHY AND HYPERPLASY OF THE LYMPHATIC ORGANS STRENGHTENING OF THE IMMUNE DEFENCE Magnesium phosphoricum 6/12/30/200X Juglans regia 3X D-L Malic Ac./Fumaricum Ac./Pyruvicum Ac. Trychinoil/Natrium oxalac. Lymphagogue action and stabilization of the vasal walls tone with consequent reduction of the extudate and the lymphoedema. Hydrastis 1X Juglans 3X Graphites 6/12/30/200X Hindrance to the proliferative proneness of the lymphoepitelial tissues 207

208 PSYCHE GUNA-DIUR P N E I HYPOPHYSIS AMILORIDE SPIRONOLACTONE HYDROCHLOROTHIAZIDE APIS BERBERIS SOLIDAGO MOUSE EAR HAWKWEED SOMA I E N P PSYCHE Dipartimento Scientifico Guna S.p.a.

209 GUNA-DIUR Berberis T Solidago T Mouse Ear Hawkweed T Apis 2X Low dilution homeopathic drugs Organ preparations Low dilution allopathic drugs Hypophysis 12X Hydrochlorothiazide 4X Amiloride 4X Spironolactone 4X Diuretic recommended for water retention and as a support in slimming diets Dipartimento Scientifico Guna S.p.a.

210 ACTION OF HYPOPHYSIS AND KIDNEY TROPISM INGREDIENTS OF GUNA-DIUR - HYPOPHYSIS 12X - Diuretic ADH Reduction of tubular reabsorption AMILORIDE X4 SPIRONOLACTONE 4X action for antialdosteronic activity BERBERIS T SOLIDAGO T MOUSE EAR HAWKWEED T Stimulation of excretion IDROCLOROTIAZIDE 4X Dipartimento Scientifico Guna S.p.a.

211 Synergic action between Apis and the other ingredients of GUNA- DIUR Drainage of extracell fluids Reabsorption of extracell fluids. Recovery from oedema Kidney excretion of extracell fluids due to stimulation of kidney draining function by: MOUSE EAR HAWKWEED SOLIDAGO BERBERIS APIS 2X 2005 Dipartimento Scientifico Guna S.p.a. 211

212 GUNA PROTOCOLS FOR HOME THERAPY TO USE BETWEEN TWO AESTHETICS MEDICINE TREATMENTS IN ORDER TO KEEP THE RESULTS UNDER CONTROL FOR CELLULITIS ANTI AGE SKIN 3 5 PELLETS 2 TIMES A DAY + ANTI AGE CELL 3 5 PELLETS 2 TIMES A DAY + ANTI AGE VEIN 3 5 PELLETS 2 TIMES A DAY FOR SKIN AGING ARD ESILEN EMULSION APPLY MORNING AND EVENING + ANTI AGE FACE 3 5 PELLETS 2 TIMES A DAY FOR BREAST TONIFICATION NATUR 4 CREAM FOR LEG TONIFICATION NATUR 5 CREAM FOR BODY AND FACE REVITALIZING NATUR 4 CREAM APPLY MORNING AND EVENING APPLY MORNING AND EVENING APPLY MORNING AND EVENING FOR WRINKLES ANTI AGE SKIN 3 5 PELLETS 2 TIMES A DAY + SERUM VITAE CREAM APPLY MORNING AND EVENING ALL THE A.M. PRODUCTS CAN BE TAKEN OVER EXTENDED PERIOD OF TIME 212

213 Stimulation of dermis metabolism*. Eutrophic action**. Stimulation of protein synthesis (especially of Collagen)***. Interleukin 1-beta* 5C ANTI AGE FACE Russian Ginseng 3X Ginseng 3X REVITALIZING AND TONIC ACTION Catalyzing and metabolic action. Eutrophic action (Ginsenosides). Skin tissue, porcine** 4C Collagen, porcine** 4C Leucine*** 4C METABOLIC ACTIVATION STIMULATION OF MICROCIRCULATION Hamamelis virg. 3X Isoleucine*** 4C Proline*** 4C ANTIOXIDANT ACTION Antioxidant action on the skin. Germanium 4C Stabilization of vessel tonus and permeabilility. 213

214 ANTI AGE SKIN Rehydrating, remineralization, detoxication and drainage action; recovery of skin elasticity. Skin tissue 4C* Placenta tot. suis 4C** Capillary tissue 4C** Collagen 4C*** TROPHIC ACTION Trophic skin stimulation*. Stimulation of vascularization**. Neo-synthesis of autologous collagen***. Vitamin E 4C* Knotted wrak 4C Fucus vesiculosus 4C Brown algae serratus 4C ANTIAGING ACTION ANTIOXIDANT ACTION Vitamin A 4C* Selenium met. 4C** Coenzyme Q 4C** Platycarpus 4C Laminaria 4C Sea lettuce 4C Selenium met. 4C Anabolic* and anticatabolic** action. PROTEIN NEOSYNTHESIS Leucine 4C* Isoleucine 4C** Action against free radicals and skin photoaging*. Stimulation of cell respiration**. 214

215 ANTI AGE VEIN Hindrance to the connective tissue tendency to slackening Arsenicum alb. 12X Calcarea fluorica 8X Cinchona off. 10X Ferrum met. 10X Viscum album 3X Aconitum 10X Ananassa 3X Arnica m. 10X Belladonna 10X Mercurius sol. 10X Pulsatilla 10X ANTIINFLAMMATORY CORE ANTI- DEGENERATIVE CORE PHLEBOTONIC CORE FUNCTIONAL RECOVERY CORE Decrease of inflammatory episodes. Decrease of pain symptoms. Artery, porc. 4C Lymph vessel., porc. 7C Vein, porc. 4C Improvement of vessel tonus and stabilization of vasal permeability*. Improvement of venous reflux and lymphagogue action**. Aesculus* 3X Arnica m.* 10X Hamamelis virg.* 3X Lachesis* 10X Ananassa** 3X Apis mell.** 10X Hydrocotyle** 3X Mount. Cranberry** 3X Functional stimulation of arteries, veins and lymph vessels. 215

216 HOME THERAPY TAMANU ARNICA cream 1 APPLICATION BEFORE SLEEPING MASSAGE GENTLY X 4 5 MINUTES 216

217 SERUM VITAE Trattamento topico delle rughe e del rilassamento cutaneo Stimolazione della sintesi del collagene autologo da parte dei fibroblasti Ottimizzazione del livello energetico della cellula attraverso la stimolazione della transacetilazione dell Ac. piruvico: chiave biochimica d accesso al ciclo di Krebs. Coenzyme A Collagen Corn oil PEG 6 esters Ethoxildiglycol Embryo extract Stimolazione della sintesi dei componenti strutturali della matrice connettivale. Stimolazione della vascolarizzazione. Azione antidegenerativa Eccipienti che permettono la completa biodisponibilità e l ottimale assorbimento percutaneo del composto Dipartimento Scientifico GUNA 217 S.p.a.