Role of Partnerships in Developing Innovative Vaccines: Brazil
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1 Role of Partnerships in Developing Innovative Vaccines: Brazil SAGE Meeting, October 2010 Reinaldo Guimarães, M.D, MSc. Secretary of Science, Technology and Strategic Inputs Ministry of Health of Brazil
2 Context Public sector (Unified Health System SUS) responsible for 95% of the national human vaccine market National Immunization Program (PNI) Created in 1973 in order to offer and distribute vaccines to the Brazilian population The State offers through this Program more than 15 vaccines: BCG (intradermal); Hepatitis B; Oral poliomyelitis vaccine (OPV); DTPw + Hib; Hib (Haemophilus influenzae b); DTPw (Diphtheria- Tetanus-Pertussis); Influenza; Rotavirus Oral Human Vaccine Monovalent G1 (P8); Yellow fever; Measles-Mumps-Rubella (MMR); Influenza; Pneumococcal 10-valent
3 The vaccines that are offered to specific population groups Hepatitis A Hepatitis B Influenza DTPa (Acellular DTP) Pneumococcal 7-valent conjugate Pneumococcal 23-valent Inactivated poliomyelitis vaccine (IPV) Meningococcal group C conjugate Pentavalent (DTPw Hib-Hepatitis B) Rabies Human immunoglobulins against hepatitis B Antitetanus Varicella-zoster (chickenpox)
4 Strategies for immunization actions PNI available infrastructure 33,000 vaccination centers 41 specialized immunobiological reference centers Some successful cases: H1N1 pandemic influenza vaccine campaign more than 85,3 million doses administrated Rubella campaign in 2008: 96.75% coverage
5 National Immunization Program/PNI: strategies Routine ~ vaccination centers 39 Reference Centers for Special Immunobiologicals (CRIE) Vaccination strategies Campaigns Influenza ( 60 years) 1 per year Measles (< 5 years) follow-up every 4 years, or as epidemiological situation indicates Source: SVS/CGPNI/SES Control Outbreak response
6 Brazilian Vaccine Market PNI vaccines are produced mainly by two state-owned (SO) institutions: Butantan Institute (São Paulo) and Bio-Manguinhos (Rio de Janeiro). There are three other producers: Ataulpho de Paiva Foundation (FAP): BCG-ID (Private non-profit) Ezequiel Dias Foundation (Funed): conjugated meningococcal C (SO) Paraná Institute of Technology (Tecpar): rabies (animal use) (SO) Public purchases encompass more than 90% of the Brazilian Vaccine Market.
7 Vaccines budget Routine PNI approved budget 2010 around US$ 1 billion/year in 2010, considering that, from all this amount, U$ 600 million are targeted as extra budget for campaigns and new vaccines: H1N1 pandemic influenza vaccine (campaign) Meningococcal group C conjugate vaccine (new on routine vaccination) 10-valent Pneumococcal (new on routine vaccination)
8 Vaccine production Bio-Manguinhos and Butantan have technological and production process expertise for traditional vaccines: Butantan Institute: Hepatitis B, Influenza, rabies in cell culture, DT (for adult and children), DTP Bio-Manguinhos: yellow fever, DTP + Hib, Hib, Measles- Mumps-Rubella (MMR), OPV, rotavirus, Pneumococcal
9 Vaccine production targets Vaccine production targets on new technologies New generation of vaccines Process of antigen conjugation Priorities for complete technology transfer processes Rotavirus, influenza, meningococcal A and pneumococcal Transfer agreements conditions (large tradition): First step: incorporation of the final products Second step: development through a logical step-wise process Explicit deadlines, prices, markets and royalties
10 Research and development field Research predominantly related to clinical phases Some pre-clinical initiatives in-house Some established research on adjuvants Collaboration among manufacturers Two complementary strategies of development: autonomic research development technology transfer agreements New vaccines or combination of vaccines: Rational vaccine application planning Focus on reducing the number of injections Ongoing project for a pentavalent vaccine (DTP + Hib + HepB) Planning for a heptavalent vaccine (DTPw + Hib + Hepatitis B + IPV + Meningococcal), delivering seven antigens in only one injection.
11 THANK YOU! Reinaldo Guimarães Secretary of Science, Technology and Strategic Inputs Ministry of Health of Brazil
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