AAHL s Regional One-Health Activities

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1 International partnerships Disease reservoirs Unique capability AAHL s Regional One-Health Activities Dr. Kurt Zuelke Director, Health & Biosecurity and AAHL 30 October th Asia Pacific Workshop on Multi-Sectoral Collaboration for the Prevention and Control of Zoonoses Sapporo, Japan HEALTH & BIOSECURITY AND AAHL

2 One-Health Healthy people, animals, plants, environment CSIRO s Health & Biosecurity business including AAHL o o o o Protects agricultural market access and trade Mitigates impacts of emerging infectious diseases and reduces biological threats Improves industry profitability and environmental health by reducing invasive species impacts Transforms health system performance and patient experience via digital technology and precision medicine Global Prevention ONE HEALTH People National Biosecurity: critical to national security, trade and health Economic

3 AAHL: a unique global high-containment centre Winnipeg, Canada Ames, IA, USA Plum Island, NY, USA Pirbright, UK Riems, Germany = PC3 = PC3 & PC4 National Centres for Animal Disease CANADA National Animal Disease Centre USA Plum Island Animal Disease Centre USA The Pirbright Institute UK Friedrich Loeffler Institute GERMANY AAHL - AUSTRALIA Geelong, Australia

4 International Reference Laboratory Designations OIE Collaborating Centre for New and Emerging Diseases OIE Collaborating Centre for Veterinary Laboratory Capacity Building OIE Reference laboratory for Avian Influenza Newcastle Disease Bluetongue Viruses Hendra and Nipah Virus Diseases Epizootic Haematopietic Necrosis Yellowhead Disease Infection with Abalone Herpes-like Virus Infection with Ranavirus FAO Reference Centre for Animal Influenza and Newcastle Disease WHO Collaborating Centre for SARS FAO Reference Centre for Laboratory Biological Risk Management

5 AAHL s role in the Region A partner for biosecurity and health in Asia Mongolia China Bhutan Taiwan AAHL s Regional Program contributes to: food and health security improved public health in Asia Pacific region India Nepal Laos Bangladesh Myanmar Thailand Sri Lanka Philippines Vietnam Cambodia Malaysia Singapore East Timor soft diplomacy Indonesia enhanced regional biosecurity partnering and capability

6 FAO H7N9 Response: AAHL provides laboratory assistance in South and Southeast Asia Regional/global concern that A(H7N9) will spread outside of China via poultry movement FAO and its Reference Centres provided assistance to member countries with surveillance and preparedness for A(H7N9) incursion AAHL assisted by production and distribution of A(H7N9) diagnostic kits to region under FAO Program (funded by USAID): H7 & N9 PCR primers/probe (8000x rxn kits each to 10 countries) Inactivated A/Anhui/1/2013 reference control A(H7N9) chicken antisera for serology (HI)

7 AAHL works with Lao NAHL and FAO to characterize newly emergent novel A(H5N6) HPAI virus [Mar 2014] SOURCE: Wong et al. Reassortant highly pathogenic influenza A(H5N6) Virus in Laos. Emerg Infect Dis Mar [date cited].

8 Philippines partnership for outbreak investigation and zoonotic disease diagnosis and control Debbie Eagles (AAHL Duty Vet) joined WHO outbreak investigation team in Mindinao in 2014 ACIAR Henipavirus Project (Funded by Australian DFAT) 2015 Partnering with Philippine Dept of Health (RITM and regional health units); Department of Ag (BAI, Philippine Animal Health Centre, regional DA staff) AAHL team training lab and field teams in biosafety, tissue sample preparation and handling, and ELISA diagnostic test protocols Field teams sampling horses, pigs and dogs in Mindinao and interviewing owners of animal being sampled 230 sera from horses, pigs and dogs collected and screened via ELISA (reactor samples will be sent to AAHL for virus neutralisation confirmation testing) WHO funded 3 month training visit for head of RITM s Special Pathogens Laboratory to train with AAHL s ebola virus team in Geelong AAHL provided research reagents for Ebola reston serologic testing to both RITM and BAI

9 OIE Twinning Project between Thai National Institute of Animal Health (DLD) and AAHL Project aims to enhance NIAH s QA systems and diagnostic capabilities for conducting outbreak investigations of emerging and potentially zoonotic infectious diseases Technical focus on employing next generation sequencing techniques for emerging infectious disease investigation and diagnosis Key achievements to date: External gap analysis of NIAH capacity to diagnose EID s recommendations made for QA improvements and upgrading PCR area NIAH conducted internal review of historic and recent outbreaks, possible disease incursions, and existing biorisk management to identify SOP s that require updating for EID investigations AAHL reviewed NIAH BSL3 facility - made recommendations for improving workflow efficiency and enhancing safe biorisk practices AAHL is currently hosting two NIAH scientists for training focused on EID diagnostics for unknowns including regional test assay development and validation, agent characterisation using next generation sequencing, and virus isolation AAHL transferred diagnostic reagents, cell cultures, and PCR controls to NIAH Related workshop on Molecular and Serological Detection of Nipah Virus: Emphasizing Associated Safety Practices conducted with US CDC, Thai MOPH, and AAHL AUG 2015; 2 animal health and 4 human health labs participated

10 Key partners include: AAHL s International Partners/Customers

11 Thank You HEALTH & BIOSECURITY AND AAHL