Diagnostic and Pharmaceutical News for You and Your Medical Practice

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1 16MS5075 BioTherapeutics Q u a r t e r l y Diagnostic and Pharmaceutical News for You and Your Medical Practice Volume 22/Winter 2016

2 2 016 Welcome to the Worry-Free Guarantee Flu Vaccine Program Celebrating 10 years of delivering ON OUR GUARANTEES to you! Fluvirin Multi-Dose Vials, 4 years and older (TIV) Fluvirin Prefilled Syringe, 4 years and older (TIV) Fluad Prefilled Syringe, 65 years and older (TIV) NEW! Afluria Multi-Dose Vial, 9 years and older (TIV) Afluria Prefilled Syringe, 9 years and older (TIV) Fluzone Quadrivalent Multi-Dose Vial, 6 months and older (QIV) Fluzone Quadrivalent Single-Dose Vial, 36 months and older (QIV) Fluzone Quadrivalent Prefilled Syringe, 36 months and older (QIV) Fluzone Quadrivalent Pediatric Prefilled Syringe, 6 35 months (QIV) Fluzone Quadrivalent ID Prefilled Syringe, years (QIV) Fluzone High-Dose Prefilled Syringe, 65 years and older (TIV) Flulaval Quadrivalent Multi-Dose Vial, 3 years and older (QIV) Fluarix Quadrivalent Prefilled Syringe, 3 years and older (QIV) Flublok Single-Dose Vial, 18 years and older (TIV), Egg-Free, Preservative-Free & Antibiotic-Free (TIV) = Trivalent Influenza Vaccine (QIV) = Quadrivalent Influenza Vaccine for your Flu Vaccine Needs! Call your Henry Schein Sales Consultant for more information or call *Terms and conditions subject to change 2016 Henry Schein Inc. No copying without permission. Not responsible for typographical errors. BQ BioTherapeutics 2

3 BQ BioTherapeutics Q u a r t e r l y Volume 22/Winter 2016 Table of Contents 4 A Letter to Henry Schein s Valued Customers 5 New Drug Approvals 6 NIH Research Matters: Comparing Blood Pressure Control Targets 9 National Center for Chronic Disease Prevention and Health Promotion: National Chronic Kidney Disease Fact Sheet 15 CDC Vital Signs: Daily Pill Can Prevent HIV Reaching People Who Could Benefit from PrEP 21 CDC Preventing Chronic Disease: Recommendation to Reduce Patients Blood Pressure and Cholesterol Medication Costs 24 National Institutes of Health: Cervical Cancer Fact Sheet 27 CDC Vital Signs: Heart Age 33 CDC: Health Behaviors and Follow-Up Care Among Colorectal Cancer Survivors 37 NIH Research Matters Molecule Proves Key to Brain Repair After Stroke The BioTherapeutics Journal is published four times a year by Henry Schein, Inc. Henry Schein s corporate headquarters are located at 135 Duryea Road, Melville, NY For journal sales information or to report corrections, BQJournal@henryschein.com or call Kim Crabtree at Note that although we attempt to ensure the currency of the information contained in this publication as of the publication date, new biotherapeutic developments occur continually and, therefore, may not be noted in this publication. Not responsible for typographical errors. 3 BQ BioTherapeutics

4 A Letter to Henry Schein s Valued Customers As we enter a new year in 2016, we would like to pause and say thank you to all of our valued customers promises to be an interesting year as our industry continues to evolve. The BioTherapeutics journal will continue with it s mission to provide you with current, relative information in the diagnosis, prevention, and treatment of disease. Heart disease continues to affect our nation for most U.S. adults ages 30-74, their heart age is much older than their actual age, especially for men and African-Americans. These groups also are more likely to have risk factors that increase heart age. Mississippi, West Virginia, Louisiana, Kentucky, and Alabama are the five states that have the highest percentage of adults with heart ages 5 or more years older than their actual age, while the five states with the lowest are Utah, Colorado, California, Massachusetts, and Hawaii. Read the latest CDC Vital Signs: Heart Age article on page 27 for more information. Blood pressure and cholesterol are two topics essential to overall health. On page 6, the NIH article Comparing Blood Pressure Control Targets discusses how adults treated at a target blood pressure level lower than commonly recommended have reduced risk of cardiovascular disease and death. On page 21, the article Recommendation to Reduce Patients Blood Pressure and Cholesterol Medication Costs state that patient out-of-pocket costs can be reduced when combined with additional interventions aimed at improving patient-provider interaction and patient knowledge, such as team-based care with medication counseling and patient education. More than 10% of adults in the United States more than 20 million people have Chronic Kidney Disease. Continue to page 9 and check out the National Chronic Kidney Disease Fact Sheet for more information on this growing disease. The CDC Vital Signs: Daily Pill Can Prevent HIV on page 15 discusses how PrEP medicine taken daily can be used to prevent high-risk people from getting HIV. Daily PrEP can reduce the risk of getting HIV from sex by more than 90%. Approximately 1.2 million people have HIV but 1 in 8 do not know it. About 40,000 HIV infections are diagnosed each year in the U.S. Colorectal cancer is one of the most common cancers in the United States. More than 1 million Americans alive today are colorectal cancer survivors, or people who have been told they have colorectal cancer. On page 33, the CDC article Health Behaviors and Follow-Up care Among Colorectal Cancer Survivors discusses health recommendations to pass along in order to reduce future health risks. We hope you find the topics featured in this volume informative. If you have suggestions for future topics, please forward them to BQJournal@henryschein.com and we will review your request. Sincerely, Kim Crabtree Director of Pharmaceuticals OUR Mission To provide health care professionals with a practical and relevant source of information regarding diagnostics, pharmaceuticals, and vaccines in a quick and easy-to-read publication that provides educational updates and insight to assist you in prevention, diagnosis, and treatment of disease. 4 BQ BioTherapeutics

5 NEW DRUG APPROVALS December 15, 2015 Bridion (sugammadex) Injection Treatment for: Reversal of Nondepolarizing Muscle Relaxants Bridion (sugammadex) is a novel selective relaxant binding agent (SRBA) for the reversal of neuromuscular blockade induced by rocuronium or vecuronium. Manufacturer: Merck & Co., Inc. December 11, 2015 Vistogard (uridine triacetate) Oral Granules Treatment for: Fluorouracil Overdose and Capecitabine Overdose Vistogard (uridine triacetate) is a pyrimidine analog indicated for the emergency treatment of adults and children who receive an overdose of the cancer treatments fluorouracil or capecitabine. Manufacturer: Wellstat Therapeutics Corporation December 11, 2015 Alecensa (alectinib) Capsules Treatment for: Non-Small Cell Lung Cancer Alecensa (alectinib) is an oral anaplastic lymphoma kinase (ALK) inhibitor for the treatment of people with ALK-positive, locally advanced or metastatic non-small cell lung cancer (NSCLC) who have progressed on or are intolerant to crizotinib. Manufacturer: Genentech, Inc. December 7, 2015 QuilliChew ER (methylphenidate hydrochloride) Extended Release Chewable Tablets Treatment for: Attention Deficit Disorder QuilliChew ER (methylphenidate hydrochloride) is a central nervous system (CNS) stimulant indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Manufacturer: Pfizer Inc. December 7, 2015 Bendeka (bendamustine hydrochloride) Injection Treatment for: Chronic Lymphocytic Leukemia, non-hodgkin s Lymphoma Bendeka (bendamustine hydrochloride) is an alkylating drug indicated for treatment of patients with chronic lymphocytic leukemia (CLL) and patients with indolent B-cell non-hodgkin lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab-containing regimen. Manufacturer: Eagle Pharmaceuticals, Inc. November 24, 2015 Fluad (influenza vaccine, adjuvanted) Injection Treatment for: Influenza Prophylaxis Fluad (influenza vaccine, adjuvanted) is an inactivated influenza vaccine indicated for the prevention of seasonal influenza in people 65 years of age and older. Manufacturer: Seqirus 5 BQ BioTherapeutics

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19 These services will support revenue generation and the expansion of services in your facility. In-Office Rx Dispensing Dispense prepackaged medications to improve patient health, lower costs and enhance revenue streams. Stocking of your most commonly prescribed generic medications will cover approximately 80% of patient needs. Call: Visit: sampling program A free and secure online service for Eligible* prescribers. Increase patient compliance: 30% of patients fill a Rx only when provided a sample, regardless of their age, income or gender** *Only eligible prescribers are able to enroll and order samples through the Henry Schein Rx Samples Service.Prescribers can check their eligibility by calling or visiting the website. **Source: Datamonitor Call: Visit: 19 BQ BioTherapeutics

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26 BRAND PROMISE PORTABLE CRYOSURGICAL SYSTEM Portable Cryosurgical System With 2 80-mL Canisters Portable cryosurgical system for the treatment and removal of 9 indicated warts and benign lesions. Patented charging system is safe, with no mess or wasted product. Patient-friendly with 2 sizes of soft applicators and short treatment times. Safe to use on the neck and facial areas. Safe dispensing system: Patented shield design with no waste or mess Fast-charging applicators: Easy, 3-step process in 15 seconds Short treatment times: One-time application takes less than 1 minute for most indications Portable Cryosurgical System ( )...ea Contains: 2 80-mL canisters, 36 5-mm applicators, 24 2-mm applicators & 4 charging actuators. Rely On Us for Quality, Selection and Performance. BQ BioTherapeutics 26

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31 NEW! Acnizil is formulated with a proprietary and patented nanoparticulate silver clinically proven to kill the Propionibacterium acnes (P. acnes) bacteria. Acnizil does not require a prescription & can be used on mild, moderate and severe acne. EXCLUSIVE! ( ) Acnizil 1.5 oz. Tube (12/Case) Acne is very common during pregnancy but there are very few safe treatment options as many prescription and over the counter products should not be taken while pregnant. Acnizil is a great alternative to antibiotics. It is a safe and effective way for patients to manage acne while they are pregnant. Michael Swor, MD, OB/GYN For more information visit: 31 BQ BioTherapeutics

32 BRAND PROMISE ONE STEP+ IFOBT OCCULT BLOOD MONOCLONIAL ANTIBODY KITS ONE STEP+ IFOBT OCCULT BLOOD MONOCLONIAL ANTIBODY KITS Innovative dry-base collection method that utilizes 1 sampling card for the collection of 2 fecal specimens, and requires only 1 immunochemical specimen preparation tube/test cassette system for analysis. Meets the American Cancer Society and the US Task Force for Colorectal Cancer (CRC) Foundation recommendation of multiple-day testing The sampling tab technology replaces unpleasant liquid buffer tubes and eliminates human error due to patient oversampling No dietary or drug restrictions 30-day stability/24-month shelf life from date of manufacture CLIA waived Made in the USA 25-Test Complete Kit ( ) tests/kit Contains: 25 test cassettes, 25 buffer tubes & 25 patient return mailers. Cassettes ( )... 30/box Contains: 30 test cassettes & 30 buffer tubes. 20 Patient Mailer Kits ( )... 20/pkg Contains: 20 postal-approved envelopes, each containing 1 sampling card slide, 2 applicators & patient instructions. 25-Test Complete Kit CPT Codes: 82274QW /G0328QW Rely On Us for Quality, Selection and Performance. BQ BioTherapeutics 32

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43 STOP MRSA NOW with SilvrSTAT! SilvrSTAT* is the only multivalent silver FDA-indicated to inhibit & kill MRSA! MRSA is one of the most troubling health care concerns causing over 94,000 hospitalization and 18,000 deaths per year SilvrSTAT is a NEW type of silver that immediately and continuously kills harmful bacteria A MORE POWERFUL MANAGEMENT OPTION! Consider SilvrSTAT if you are using the following products: Silvadene (silver sulfadiazene) Silvasorb SilverMed and Amerigel Gentell s Silver Hydrogel Ag Elta s SilverGel Advanced Silver DermaSyn /Ag Antimicrobial Silver any Hydrogel Bactroban (mupirocin) Protect Your Patients Against Community Acquired Infections Reimbursed as a hydrogel using HCPCS code A6248 SilvrSTAT (Rx) Antibacterial Wound Dressing Gel ( )...1 oz. ( )...3 oz. BEST VALUE Save 24% vs the 1 oz. size! *Caution: Federal law restricts the sale of this device by, or on the order of, a licensed health care practitioner. For informational purposes only. Source: ABL Medical, LLC. Customer is responsible for verification of billing/coding in accordance with applicable specific circumstances. Make one call or to our diagnostics, pharmaceutical, and vaccine experts and let us do the research it s better than a PDR for point-of-care assistance. CLINICAL Henry Schein s DxRx Hotline is a single point of contact for your organization for answers to various types of questions related to diagnostics, pharmaceuticals, and vaccines. With a mission of helping practices diagnose, prevent, and treat disease, the DxRx team is available as a trustworthy and accessible source of information at your convenience. The DxRx team is available via phone, , and Live Chat, 8 am 6 pm, et. BENEFITS: Expedite diagnosis and treatment at the point of care Free, on-demand resource for immediate needs Easy-to-access and use resource One phone call to answer pharmaceutical, diagnostic, and vaccination questions Live support with no automation FEATURES: DxRx can answer questions related to: Latest updates on supply issues Indications and usage as provided on package inserts Brand-to-generic conversions CPT and J codes* CLIA product status Product storage requirements ACIP recommendations for vaccinations Flu vaccine and flu-related topics *For informational purposes only. Source: or Customer is responsible for verification of billing/coding in accordance with applicable specific circumstance. Contact Us: DxRxSolutions@henryschein.com Visit: 43 BQ BioTherapeutics

44 Call: P-SCHEIN ( ) 8am 8:30pm (et) Fax: Hours Henry Schein, Inc. No copying without permission. Not responsible for typographical errors. 16MS5075 Take a new look at diabetes care. Enhanced and improved patient care Answers for life. Offer your patients enhanced care: HbA1c results in minutes allows adjustment of patient treatment during the office visit Immediate results reduce the need of costly and inconvenient patient call-backs and return visits NGSP certified HbA1c test with excellent correlation to reference methods ensures confidence in the results Easy to perform CLIA-waived HbA1c test can be performed in any clinical setting

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