TABLE 7 ADVANTAGES AND DISADVANTAGES OF TOXOID VACCINES SUBUNIT VACCINES Applications of Subunit Vaccines TABLE 8 APPLICATIONS OF

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1 CHAPTER ONE: INTRODUCTION... 1 STUDY OBJECTIVES... 1 REASONS FOR DOING THIS STUDY... 1 INTENDED AUDIENCE... 2 SCOPE OF THE STUDY... 2 METHODOLOGY... 2 INFORMATION SOURCES... 2 ABOUT THE AUTHOR... 3 RELATED BCC RESEARCH REPORTS... 3 BCC ONLINE SERVICES... 4 DISCLAIMER... 4 CHAPTER TWO: EXECUTIVE SUMMARY... 5 EXECUTIVE SUMMARY... 5 SUMMARY TABLE GLOBAL REVENUE OF HUMAN AND ANIMAL VACCINES, THROUGH 2015 ($ MILLIONS)... 6 SUMMARY FIGURE GLOBAL REVENUE OF HUMAN AND ANIMAL VACCINES, ($ MILLIONS)... 7 CHAPTER THREE: OVERVIEW... 8 WHAT IS A VACCINE?... 8 HISTORY OF VACCINES... 8 TABLE 1 HISTORY OF VACCINES, TABLE 1 (CONTINUED)... 9 TYPES OF VACCINES... 9 ATTENUATED (LIVE) VACCINES... 9 Applications of Attenuated (Live) Vaccines TABLE 2 APPLICATIONS OF ATTENUATED (LIVE) VACCINES Advantages and Disadvantages of Attenuated (Live) Vaccines TABLE 3 ADVANTAGES AND DISADVANTAGES OF ATTENUATED (LIVE) VACCINES TABLE 3 (CONTINUED) INACTIVATED (KILLED) VACCINES Applications of Inactivated (Killed) Vaccines TABLE 4 APPLICATIONS OF INACTIVATED (KILLED) VACCINES TABLE 4 (CONTINUED) Advantages and Disadvantages of Inactivated (Killed) Vaccines TABLE 5 ADVANTAGES AND DISADVANTAGES OF INACTIVED (KILLED) VACCINES TOXOID VACCINES Applications of Toxoid Vaccines TABLE 6 APPLICATIONS OF TOXOID VACCINES Advantages and Disadvantages of Toxoid Vaccines... 13

2 TABLE 7 ADVANTAGES AND DISADVANTAGES OF TOXOID VACCINES SUBUNIT VACCINES Applications of Subunit Vaccines TABLE 8 APPLICATIONS OF SUBUNIT VACCINES Advantages and Disadvantages of Subunit Vaccines TABLE 9 ADVANTAGES AND DISADVANTAGES OF SUBUNIT VACCINES CONJUGATE VACCINES Applications of Conjugate Vaccines TABLE 10 APPLICATIONS OF CONJUGATE VACCINES Advantages and Disadvantages of Conjugate Vaccines TABLE 11 ADVANTAGES AND DISADVANTAGES OF CONJUGATE VACCINES RECOMBINANT VECTOR VACCINES Applications of Recombinant Vector Vaccines TABLE 12 APPLICATIONS OF RECOMBINANT VECTOR VACCINES Advantages and Disadvantages of Recombinant Vector Vaccines TABLE 13 ADVANTAGES AND DISADVANTAGES OF RECOMBINANT VECTOR VACCINES DNA VACCINES Applications of DNA Vaccines TABLE 14 APPLICATIONS OF DNA VACCINES Advantages and Disadvantages of DNA Vaccines TABLE 15 ADVANTAGES AND DISADVANTAGES OF DNA VACCINES INFECTIOUS DISEASES PREVENTABLE BY VACCINES HUMAN DISEASES Viral Diseases TABLE 16 VACCINE PREVENTABLE HUMAN VIRAL DISEASES TABLE 16 (CONTINUED) TABLE 16 (CONTINUED) Bacterial Diseases TABLE 17 VACCINE PREVENTABLE HUMAN BACTERIAL DISEASES TABLE 17 (CONTINUED) TABLE 17 (CONTINUED) ANIMAL DISEASES TABLE 18 VACCINE PREVENTABLE ANIMAL DISEASES IN COMPANION ANIMALS TABLE 18 (CONTINUED) TABLE 19 VACCINE PREVENTABLE ANIMAL DISEASES IN LIVESTOCK ANIMALS TABLE 19 (CONTINUED)... 26

3 TABLE 20 LIVESTOCK ANIMAL VACCINES TABLE 20 (CONTINUED) TABLE 20 (CONTINUED) TABLE 20 (CONTINUED) TABLE 20 (CONTINUED) TABLE 20 (CONTINUED) TABLE 20 (CONTINUED) TABLE 20 (CONTINUED) TABLE 20 (CONTINUED) CHAPTER FOUR: PREVALENCE INCIDENCE AND IMMUNIZATION OF HUMAN DISEASES REGIONAL DATA TABLE 21 REPORTED INCIDENCE DATA OF HUMAN DISEASES, BY REGION, TABLE 21 (CONTINUED) TABLE 22 IMMUNIZATION COVERAGE DATA OF HUMAN DISEASES, BY REGION, (%) TABLE 22 (CONTINUED) GLOBAL DATA TABLE 23 REPORTED CASES OF HUMAN DISEASES, 2007 AND TABLE 24 IMMUNIZATION COVERAGE OF HUMAN DISEASES (%) GLOBAL IMMUNIZATION UPTAKE DATA TABLE 25 UPTAKE OF NEW AND UNDERUSED VACCINES, GLOBAL DEATHS DUE TO VACCINE PREVENTABLE DISEASES TABLE 26 GLOBAL CHILD DEATHS DUE TO VACCINE PREVENTABLE DISEASES, CHAPTER FIVE: REGULATORY ASPECTS TABLE 27 REVISIONS TO EXISTING VACCINES, TABLE 27 (CONTINUED) TABLE 27 (CONTINUED) TABLE 27 (CONTINUED) TABLE 27 (CONTINUED) TABLE 27 (CONTINUED) TABLE 28 NEW VACCINES IN THE GLOBAL MARKET, TABLE 28 (CONTINUED) TABLE 28 (CONTINUED) TABLE 28 (CONTINUED) TABLE 28 (CONTINUED) CHAPTER SIX: INDUSTRY STRUCTURE WHO PREQUALIFIED VACCINE MANUFACTURERS/SUPPLIERS... 52

4 TABLE 29 WORLD HEALTH ORGANIZATION (WHO) PREQUALIFIED MANUFACTURERS/SUPPLIERS OF HUMAN VACCINES, TABLE 29 (CONTINUED) MANUFACTURERS/SUPPLIERS OF HUMAN VACCINES ATTENUATED (LIVE) VACCINES TABLE 30 LEADING MANUFACTURERS/SUPPLIERS OF ATTENUATED (LIVE) VACCINES TABLE 30 (CONTINUED) INACTIVATED (KILLED) VACCINES TABLE 31 LEADING MANUFACTURERS/SUPPLIERS OF INACTIVATED (KILLED) VACCINES CONJUGATE VACCINES TABLE 32 LEADING MANUFACTURERS/SUPPLIERS OF CONJUGATE VACCINES RECOMBINANT / RECOMBINANT DNA (RDNA) VACCINES TABLE 33 LEADING MANUFACTURERS/SUPPLIERS OF RECOMBINANT/ RECOMBINANT DNA (RDNA) VACCINES TABLE 33 (CONTINUED) SUBUNIT VACCINES TABLE 34 LEADING MANUFACTURERS/SUPPLIERS OF SUBUNIT VACCINES TOXOID VACCINES TABLE 35 LEADING MANUFACTURERS/SUPPLIERS OF TOXOID VACCINES COMBINATION VACCINES TABLE 36 LEADING MANUFACTURERS/SUPPLIERS OF COMBINATION VACCINES MARKET SHARES OF INDUSTRY LEADERS OF HUMAN VACCINES ATTENUATED (LIVE) VACCINES TABLE 37 GLOBAL MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF ATTENUATED (LIVE) VACCINES, 2009 (%) FIGURE 1 GLOBAL MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF ATTENUATED (LIVE) VACCINES, 2009 (%) INACTIVATED (KILLED) VACCINES TABLE 38 GLOBAL MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF INACTIVATED (KILLED) VACCINES, 2009 (%) FIGURE 2 GLOBAL MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF INACTIVATED (KILLED) VACCINES, 2009 (%) CONJUGATE VACCINES... 62

5 TABLE 39 GLOBAL MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF CONJUGATE VACCINES, 2009 (%) FIGURE 3 GLOBAL MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF CONJUGATE VACCINES, 2009 (%) RECOMBINANT/RECOMBINANT DNA (RDNA) VACCINES TABLE 40 GLOBAL MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF RECOMBINANT/RECOMBINANT DNA (RDNA) VACCINES, 2009 (%) FIGURE 4 GLOBAL MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF RECOMBINANT/RECOMBINANT DNA (RDNA) VACCINES, 2009 (%) SUBUNIT VACCINES TABLE 41 GLOBAL MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF SUBUNIT VACCINES, 2009 (%) FIGURE 5 GLOBAL MARKET SHARES OF MANUFACTURERS/ SUPPLIERS OF SUBUNIT VACCINES, 2009 (%) TOXOID VACCINES TABLE 42 GLOBAL MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF TOXOID VACCINES, 2009 (%) FIGURE 6 GLOBAL MARKET SHARES OF MANUFACTURERS/ SUPPLIERS OF TOXOID VACCINES, 2009 (%) COMBINATION VACCINES TABLE 43 GLOBAL MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF COMBINATION VACCINES, 2009 (%) FIGURE 7 GLOBAL MARKET SHARES OF MANUFACTURERS/SUPPLIERS OF COMBINATION VACCINES, 2009 (%) CHAPTER SEVEN: NEW DEVELOPMENTS NEW DEVELOPMENTS TABLE 44 NEW DEVELOPMENTS IN THE RESEARCH PIPELINE OF HUMAN VACCINES (AS OF AUGUST 2010) TABLE 44 (CONTINUED) TABLE 44 (CONTINUED) TABLE 44 (CONTINUED) TABLE 44 (CONTINUED) TABLE 44 (CONTINUED) CHAPTER EIGHT: MARKET ANALYSIS: HUMAN... 75

6 TABLE 45 GLOBAL MARKET FOR HUMAN VACCINES BY REGION, THROUGH 2015 ($ MILLIONS) FIGURE 8 GLOBAL MARKET FOR HUMAN VACCINES BY REGION, ($ MILLIONS) ATTENUATED (LIVE) VACCINES MARKET OVERVIEW MARKET REVENUE TABLE 46 GLOBAL MARKET FOR ATTENUATED (LIVE) VACCINES, BY REGION, THROUGH 2015 ($ MILLIONS) FIGURE 9 GLOBAL MARKET FOR ATTENUATED (LIVE) VACCINES, BY REGION, ($ MILLIONS) INACTIVATED (KILLED) VACCINES MARKET OVERVIEW MARKET REVENUE TABLE 47 GLOBAL MARKET FOR INACTIVATED (KILLED) VACCINES, THROUGH 2015 ($ MILLIONS) FIGURE 10 GLOBAL MARKET FOR INACTIVATED (KILLED) VACCINES, ($ MILLIONS) CONJUGATE VACCINES MARKET OVERVIEW MARKET REVENUE TABLE 48 GLOBAL MARKET FOR CONJUGATE VACCINES, THROUGH 2015 ($ MILLIONS) FIGURE 11 GLOBAL MARKET FOR CONJUGATE VACCINES, ($ MILLIONS) RECOMBINANT/RECOMBINANT DNA (RDNA) VACCINES MARKET OVERVIEW MARKET REVENUE TABLE 49 GLOBAL MARKET FOR RECOMBINANT/RECOMBINANT DNA (RDNA) VACCINES, THROUGH 2015 ($ MILLIONS) FIGURE 12 GLOBAL MARKET FOR RECOMBINANT/RECOMBINANT DNA (RDNA) VACCINES, ($ MILLIONS) SUBUNIT VACCINES MARKET OVERVIEW MARKET REVENUE TABLE 50 GLOBAL MARKET FOR SUBUNIT VACCINES, THROUGH 2015 ($ MILLIONS) FIGURE 13 GLOBAL MARKET FOR SUBUNIT VACCINES, ($ MILLIONS) TOXOID VACCINES MARKET OVERVIEW MARKET REVENUE TABLE 51 GLOBAL MARKET FOR TOXOID VACCINES, THROUGH 2015 ($ MILLIONS)... 91

7 FIGURE 14 GLOBAL MARKET FOR TOXOID VACCINES, ($ MILLIONS) COMBINATION VACCINES MARKET OVERVIEW MARKET REVENUE TABLE 52 GLOBAL MARKET FOR COMBINATION VACCINES, BY REGION THROUGH 2015 ($ MILLIONS) FIGURE 15 GLOBAL MARKET FOR COMBINATION VACCINES, BY REGION, ($ MILLIONS) MARKET SHARES OF HUMAN VACCINES, BY REGION TABLE 53 GLOBAL HUMAN VACCINES MARKET SHARES BY REGION, 2009 (%) FIGURE 16 GLOBAL HUMAN VACCINES MARKET SHARES BY REGION, 2009 (%) MARKET SHARES OF HUMAN VACCINES, BY TYPE TABLE 54 GLOBAL HUMAN VACCINES MARKET SHARES BY VACCINE TYPE, 2009 (%) FIGURE 17 GLOBAL HUMAN VACCINES MARKET SHARES BY VACCINE TYPE, 2009 (%) CHAPTER NINE: ANIMAL HEALTH MARKET INDUSTRY MANUFACTURERS OF ANIMAL HEALTH PRODUCTS MARKET OVERVIEW MARKET REVENUE TABLE 55 GLOBAL ANIMAL HEALTH REVENUES BY MARKET LEADERS, ($ MILLIONS) TABLE 56 GLOBAL ANIMAL HEALTH MARKET SHARES BY REVENUE, 2009 (%) FIGURE 18 GLOBAL ANIMAL HEALTH MARKET SHARES BY REVENUE, 2009 (%) ANIMAL VACCINES TABLE 57 GLOBAL MARKET FOR ANIMAL VACCINES, THROUGH 2015 ($ MILLIONS) FIGURE 19 GLOBAL MARKET FOR ANIMAL VACCINES, ($ MILLIONS) CHAPTER TEN: MARKET BY APPLICATIONS HUMANS TABLE 58 DISEASES AND INFECTIONS WITH DEVELOPED HUMAN VACCINES BASED ON MICROORGANISM TABLE 59 DISEASES AND INFECTIONS WITH DEVELOPED HUMAN VACCINES BASED ON TREATMENT MENINGOCOCCAL/PNEUMOCOCCAL DISEASES MARKET REVENUE

8 TABLE 60 GLOBAL SALES OF HUMAN VACCINES IN MENINGOCOCCAL/ PNEUMOCOCCAL DISEASES MARKET, THROUGH 2015 ($ MILLIONS) FIGURE 20 GLOBAL SALES OF HUMAN VACCINES IN MENINGOCOCCAL/ PNEUMOCOCCAL DISEASES MARKET, ($ MILLIONS) TABLE 61 TOP SELLING GROUPS OF MENINGOCOCCAL/ PENUMOCOCCAL VACCINES FOR 2009 BY MARKET SHARE (%) INFLUENZA (SEASONAL AND PANDEMIC) DISEASES MARKET REVENUE TABLE 62 GLOBAL SALES OF HUMAN VACCINES IN INFLUENZA DISEASES MARKET, THROUGH 2015 ($ MILLIONS) FIGURE 21 GLOBAL SALES OF HUMAN VACCINES IN INFLUENZA DISEASES MARKET, ($ MILLIONS) TABLE 63 TOP SELLING GROUPS OF INFLUENZA VACCINES BY MARKET SHARE, 2009 (%) PEDIATRIC/POLIO/PERTUSSIS/HIB DISEASES MARKET REVENUE TABLE 64 GLOBAL SALES OF HUMAN VACCINES IN PEDIATRIC/POLIO PERTUSSIS/HIB DISEASES MARKET, THROUGH 2015 ($ MILLIONS) FIGURE 22 GLOBAL SALES OF HUMAN VACCINES IN PEDIATRIC/ POLIO/PERTUSSIS/HIB DISEASES MARKET, ($ MILLIONS) TABLE 65 TOP SELLING GROUPS OF PEDIATRIC/POLIO/PERTUSSIS/HIB VACCINES BY MARKET SHARE, 2009 (%) ADULT/ADOLESCENT BOOSTER RELATED DISEASES MARKET REVENUE TABLE 66 GLOBAL SALES OF HUMAN VACCINES IN ADULT/ADOLESCENT BOOSTER RELATED DISEASES MARKET, THROUGH 2015 ($ MILLIONS) FIGURE 23 GLOBAL SALES OF HUMAN VACCINES IN ADULT/ADOLESCENT BOOSTER RELATED DISEASES MARKET, ($ MILLIONS) TABLE 67 TOP SELLING GROUPS OF ADULT/ADOLESCENT BOOSTER RELATED VACCINES BY MARKET SHARE, 2009 (%) TRAVEL AND OTHER ENDEMIC DISEASES MARKET REVENUE TABLE 68 GLOBAL SALES OF HUMAN VACCINES IN TRAVEL AND OTHER ENDEMIC DISEASES MARKET, THROUGH 2015 ($ MILLIONS) FIGURE 24 GLOBAL SALES OF HUMAN VACCINES IN TRAVEL AND OTHER ENDEMIC DISEASES MARKET, ($ MILLIONS)

9 TABLE 69 TOP SELLING GROUPS OF TRAVEL AND OTHER ENDEMIC VACCINES BY MARKET SHARE, 2009 (%) HPV DISEASE MARKET REVENUE TABLE 70 GLOBAL SALES OF HUMAN VACCINES IN HPV DISEASE MARKET, THROUGH 2015 ($ MILLIONS) FIGURE 25 GLOBAL SALES OF HUMAN VACCINES IN HPV DISEASE MARKET, ($ MILLIONS) TABLE 71 TOP SELLING HPV VACCINES IN THE ORDER OF THEIR SALES, 2009 (%) ROTAVIRUS DISEASE MARKET REVENUE TABLE 72 GLOBAL SALES OF HUMAN VACCINES IN ROTAVIRUS DISEASE MARKET, THROUGH 2015 ($ MILLIONS) FIGURE 26 GLOBAL SALES OF HUMAN VACCINES IN ROTAVIRUS DISEASE MARKET, ($ MILLIONS) TABLE 73 TOP SELLING ROTAVIRUS VACCINES BY MARKET SHARE, 2009 (%) OTHER DISEASES MARKET REVENUE TABLE 74 GLOBAL SALES OF HUMAN VACCINES IN OTHER DISEASES MARKET, THROUGH 2015 ($ MILLIONS) FIGURE 27 GLOBAL SALES OF HUMAN VACCINES IN OTHER DISEASES MARKET, ($ MILLIONS) TABLE 75 TOP SELLING OTHER VACCINES FOR 2009 BY MARKET SHARE (%) MARKET SHARE OF APPLICATIONS TABLE 76 SHARE OF VARIOUS CATEGORIES OF VACCINES IN THE HUMAN VACCINES MARKET, 2009 (%) FIGURE 28 SHARE OF VARIOUS CATEGORIES OF VACCINES IN THE HUMAN VACCINES MARKET, 2009 (%) CHAPTER ELEVEN: PATENT ANALYSIS TOTAL NUMBER OF PATENTS TABLE 77 NUMBER OF SIGNIFICANT PATENTS, 2006 TO SEPTEMBER FIGURE 29 NUMBER OF SIGNIFICANT PATENTS, 2006 TO SEPTEMBER FIGURE 30 PERCENT OF SIGNIFICANT PATENTS, 2006 TO SEPTEMBER 2010 (%) PATENTS BY TYPE AND YEAR TABLE 78 PATENTS BY TECHNOLOGY, 2006 TO SEPTEMBER FIGURE 31 PATENTS BY TECHNOLOGY, 2006 TO SEPTEMBER PATENTS BY COMPANY INACTIVATED (KILLED) VACCINE TECHNOLOGY

10 TABLE 79 NUMBER OF U.S. PATENTS BY COMPANY UTILIZING INACTIVATED (KILLED) VACCINE TECHNOLOGY, 2006 TO SPETEMBER FIGURE 32 NUMBER OF U.S. PATENTS BY COMPANY UTILIZING INACTIVATED (KILLED) VACCINE TECHNOLOGY, 2006 TO SEPTEMBER ATTENUATED (LIVE) VACCINE TECHNOLOGY TABLE 80 NUMBER OF U.S. PATENTS BY COMPANY UTILIZING ATTENUATED (LIVE) VACCINE TECHNOLOGY, 2006 TO SEPTEMBER FIGURE 33 NUMBER OF U.S. PATENTS BY COMPANY UTILIZING ATTENUATED (LIVE) VACCINE TECHNOLOGY, 2006 TO SEPTEMBER CONJUGATE VACCINE TECHNOLOGY TABLE 81 NUMBER OF U.S. PATENTS BY COMPANY UTILIZING CONJUGATE VACCINE TECHNOLOGY, 2006 TO SEPTEMBER FIGURE 34 NUMBER OF U.S. PATENTS BY COMPANY UTILIZING CONJUGATE VACCINE TECHNOLOGY, 2006 TO SEPTEMBER TOXOID VACCINE TECHNOLOGY TABLE 82 NUMBER OF U.S. PATENTS BY COMPANY UTILIZING TOXOID VACCINE TECHNOLOGY, 2006 TO SEPTEMBER FIGURE 35 NUMBER OF U.S. PATENTS BY COMPANY UTILIZING TOXOID VACCINE TECHNOLOGY, 2006 TO SEPTEMBER RECOMBINANT/RDNA VACCINE TECHNOLOGY TABLE 83 NUMBER OF U.S. PATENTS BY COMPANY UTILIZING RECOMBINANT/RDNA VACCINE TECHNOLOGY, 2006 TO SEPTEMBER TABLE 83 (CONTINUED) FIGURE 36 NUMBER OF U.S. PATENTS BY COMPANY UTILIZING RECOMBINANT/RDNA VACCINE TECHNOLOGY, 2006 TO SEPTEMBER SUBUNIT VACCINE TECHNOLOGY TABLE 84 NUMBER OF U.S. PATENTS BY COMPANY UTILIZING SUBUNIT VACCINE TECHNOLOGY, 2006 TO SEPTEMBER FIGURE 37 NUMBER OF U.S. PATENTS BY COMPANY UTILIZING SUBUNIT VACCINE TECHNOLOGY, 2006 TO SEPTEMBER OTHER/COMBINED VACCINE TECHNOLOGY TABLE 85 NUMBER OF U.S. PATENTS BY COMPANY UTILIZING OTHER/COMBINED VACCINE TECHNOLOGY, 2006 TO SEPTEMBER TABLE 85 (CONTINUED)

11 FIGURE 38 NUMBER OF U.S. PATENTS BY COMPANY UTILIZING OTHER/ COMBINED VACCINE TECHNOLOGY, 2006 TO SEPTEMBER PATENTS BY COUNTRY INACTIVATED (KILLED) VACCINE TECHNOLOGY TABLE 86 NUMBER OF U.S. PATENTS BY COUNTRY UTILIZING INACTIVATED (KILLED) VACCINE TECHNOLOGY, 2006 TO SEPTEMBER FIGURE 39 NUMBER OF U.S. PATENTS BY COUNTRY UTILIZING INACTIVATED (KILLED) VACCINE TECHNOLOGY, 2006 TO SEPTEMBER ATTENUATED (LIVE) VACCINE TECHNOLOGY TABLE 87 NUMBER OF U.S. PATENTS BY COUNTRY UTILIZING ATTENUATED (LIVE) VACCINE TECHNOLOGY, 2006 TO SEPTEMBER TABLE 87 (CONTINUED) FIGURE 40 NUMBER OF U.S. PATENTS BY COUNTRY UTILIZING ATTENUATED (LIVE) VACCINE TECHNOLOGY, CONJUGATE VACCINE TECHNOLOGY TABLE 88 NUMBER OF U.S. PATENTS BY COUNTRY UTILIZING CONJUGATE VACCINE TECHNOLOGY, 2006 TO SEPTEMBER FIGURE 41 NUMBER OF U.S. PATENTS BY COUNTRY UTILIZING CONJUGATE VACCINE TECHNOLOGY, 2006 TO SEPTEMBER TABLE 89 NUMBER OF U.S. PATENTS BY COUNTRY UTILIZING TOXOID VACCINE TECHNOLOGY, 2006 TO SEPTEMBER FIGURE 42 NUMBER OF U.S. PATENTS BY COUNTRY UTILIZING TOXOID VACCINE TECHNOLOGY, 2006 TO SEPTEMBER RECOMBINANT/ DNA/ RDNA VACCINE TECHNOLOGY TABLE 90 NUMBER OF U.S. PATENTS BY COUNTRY UTILIZING RECOMBINANT/DNA/RDNA VACCINE TECHNOLOGY, 2006 TO SEPTEMBER FIGURE 43 NUMBER OF U.S. PATENTS BY COUNTRY UTILIZING RECOMBINANT/DNA/RDNA VACCINE TECHNOLOGY, 2006 TO SEPTEMBER SUBUNIT VACCINE TECHNOLOGY TABLE 91 NUMBER OF U.S. PATENTS BY COUNTRY UTILIZING SUBUNIT VACCINE TECHNOLOGY, 2006 TO SEPTEMBER FIGURE 44 NUMBER OF U.S. PATENTS BY COUNTRY UTILIZING SUBUNIT VACCINE TECHNOLOGY, 2006 TO SEPTEMBER OTHER/COMBINED VACCINE TECHNOLOGY

12 TABLE 92 NUMBER OF U.S. PATENTS BY COUNTRY UTILIZING OTHER/COMBINED VACCINE TECHNOLOGY, 2006 TO SEPTEMBER FIGURE 45 NUMBER OF U.S. PATENTS BY COUNTRY UTILIZING OTHER/COMBINED VACCINE TECHNOLOGY, 2006 TO SEPTEMBER TABLE 93 NUMBER OF U.S. PATENTS BY COUNTRY FOR ALL VACCINE TYPES, 2006 TO SEPTEMBER 2010 (%) TABLE 93 (CONTINUED) FIGURE 46 PATENT SHARES BY COUNTRY FOR VACCINES, 2006 TO SEPTEMBER 2010 (%) PATENTS BY ASSIGNEE INACTIVATED (KILLED) VACCINE TECHNOLOGY TABLE 94 PATENTS BY ASSIGNEE UTILIZING INACTIVATED (KILLED) VACCINE TECHNOLOGY, 2006 TO SEPTEMBER FIGURE 47 PATENTS BY ASSIGNEE UTILIZING INACTIVATED (KILLED) VACCINE TECHNOLOGY, 2006 TO SEPTEMBER ATTENUATED (LIVE) VACCINE TECHNOLOGY TABLE 95 PATENTS BY ASSIGNEE UTILIZING ATTENUATED (LIVE) VACCINE TECHNOLOGY, 2006 THROUGH SEPTEMBER FIGURE 48 PATENTS BY ASSIGNEE UTILIZING ATTENUATED (LIVE) VACCINE TECHNOLOGY, 2006 TO SEPTEMBER CONJUGATE VACCINE TECHNOLOGY TABLE 96 PATENTS BY ASSIGNEE UTILIZING CONJUGATE VACCINE TECHNOLOGY, 2006 TO SEPTEMBER FIGURE 49 PATENTS BY ASSIGNEE UTILIZING CONJUGATE VACCINE TECHNOLOGY, 2006 TO SEPTEMBER TOXOID VACCINE TECHNOLOGY TABLE 97 PATENTS BY ASSIGNEE UTILIZING TOXOID VACCINE TECHNOLOGY, 2006 TO SEPTEMBER FIGURE 50 PATENTS BY ASSIGNEE UTILIZING TOXOID VACCINE TECHNOLOGY, 2006 TO SEPTEMBER RECOMBINANT/RDNA VACCINE TECHNOLOGY TABLE 98 PATENTS BY ASSIGNEE UTILIZING RECOMBINANT/RDNA VACCINE TECHNOLOGY, 2006 TO SEPTEMBER FIGURE 51 PATENTS BY ASSIGNEE UTILIZING RECOMBINANT/RDNA VACCINE TECHNOLOGY, 2006 TO SEPTEMBER SUBUNIT VACCINE TECHNOLOGY TABLE 99 PATENTS BY ASSIGNEE UTILIZING SUBUNIT VACCINE TECHNOLOGY, 2006 TO SEPTEMBER

13 FIGURE 52 PATENTS BY ASSIGNEE UTILIZING SUBUNIT VACCINE TECHNOLOGY, 2006 TO SEPTEMBER OTHER/COMBINED VACCINE TECHNOLOGY TABLE 100 PATENTS BY ASSIGNEE UTILIZING OTHER/COMBINED VACCINE TECHNOLOGY, 2006 TO SEPTEMBER FIGURE 53 PATENTS BY ASSIGNEE UTILIZING OTHER/COMBINED VACCINE TECHNOLOGY, 2006 TO SEPTEMBER CHAPTER TWELVE: CURRENT SITUATION OF THE GLOBAL VACCINES MARKET FACTS ABOUT THE GLOBAL VACCINES MARKET FACTORS AFFECTING THE SALES OF VACCINES COMPETITION COST TRENDS IMMUNIZATION FUNDING GLOBAL IMMUNIZATION VISION AND STRATEGY (GIVS) TABLE 101 AIMS OF GIVS TABLE 102 GOALS OF GIVS TABLE 103 STRATEGIES OF GIVS CURRENT SITUATION TABLE 104 GLOBAL FUNDING GAP BY REGION FOR IMMUNIZATION WORK, ($ MILLIONS) VACCINE PREVENTABLE DISEASES UPDATE CURRENT VACCINE PRIORITIZATION TABLE 105 VACCINE PRIORITIZATION, CURRENT AND FUTURE (PROPOSED) VACCINE MILESTONES TABLE 106 VACCINE MILESTONES INFLUENZA VIRUS VACCINES UPDATE FOR THE 2010 THROUGH 2011 SEASON TABLE 107 INFLUENZA VACCINES FOR THE SEASON CHAPTER THIRTEEN: COMPANY PROFILES ADVAXIS BAYER ANIMAL HEALTH BUL BIO NATIONAL CENTER OF INFECTIOUS AND PARASITIC DISEASES LTD. (BB NCIPD LTD.) BHARAT BIOTECH BIO FARMA BIOLOGICAL E. LIMITED BIO MANGUINHOS BIOPROPERTIES

14 BOEHRINGER INGELHEIM VETMEDICA, INC CENTER FOR GENETIC ENGINEERING AND BIOTECHNOLOGY CEVA SANTE ANIMALE COLORADO SERUM COMPANY CRUCELL CSL LTD ELI LILLY & CO EMERGENT BIOSOLUTIONS FATRO GLAXOSMITHKLINE GREEN CROSS HAFFKINE BIO PHARMACEUTICAL CORPORATION LTD INDOVAX INSTITUT PASTEUR DE DAKAR INTERCELL JAPAN BCG LABORATORY KING PHARMACEUTICALS INC LOHMANN INTERNATIONAL MEDIMMUNE MERCK & CO., INC NIPPON BIOLOGICALS, INC NOVARTIS AG PANACEA BIOTEC PFIZER INC ROMVAC SANOFI AVENTIS (SANOFI PASTEUR) SERUM INSTITUTE OF INDIA LTD STATENS SERUM INSTITUT THE RESEARCH FOUNDATION FOR MICROBIAL DISEASES OF OSAKA UNIVERSITY VENTRI BIOLOGICALS ZYDUS CADILA APPENDIX I ABBREVIATIONS ABBREVIATIONS (CONTINUED)

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