Experience with implementation of Xpert MTB/RIF in India. Dr K S Sachdeva Addl. DDG (TB), Government of India

Size: px
Start display at page:

Download "Experience with implementation of Xpert MTB/RIF in India. Dr K S Sachdeva Addl. DDG (TB), Government of India"

Transcription

1 Experience with implementation of Xpert MTB/RIF in India Dr K S Sachdeva Addl. DDG (TB), Government of India

2 Background Two ongoing projects being implemented in India, under RNTCP by FIND Gene Xpert feasibility and Impact study Collect evidence on the feasibility and impact of introducing CBNAAT at decentralized labs on TB and Rifampicin resistance detection EXPANDx TB CBNAAT project Establish 12 CBNAAT labs for Rif DST to supplement the capacity of the existing reference lab network of NTP in difficult areas

3 Xpert Feasibility and Impact study EXPANDx TB Xpert project Rural - 3,370,324 (7) Urban 2,862,482 (5) Tribal - 1,611,537 (4) Urban Slum - 602,328 (1) Hilly - 260,000 (1) Population 8,7 Mill (18 sites)

4 Aim Gene Xpert feasibility and Impact study o Collect evidence on the feasibility and impact of introducing CBNAAT for the detection of TB and Rifampicin resistance Objectives o Feasibility: Establish the feasibility of decentralized deployment of routine CBNAAT testing all pulmonary TB & DR-TB suspects in selected geographic areas o Impact: Assess the impact of decentralized deployment of routine CBNAAT testing of all pulmonary TB suspects on diagnosis of TB & DR-TB Approach o Programmatic demonstration with before/after comparison from same sites; Phased implementation

5 Gene Xpert feasibility and Impact study Feasibility Outcomes Infrastructure requirements Test failure rates under field conditions Effect of operating temperature & Electrical power requirements Minimum training needs Description quality assurance requirements Impact Outcomes Detection of TB & DR-TB cases Delay and treatment outcomes HIV-TB & paediatric cases Referral from the private sector Cost effectiveness modelling Feasibility and costs of solar powered back-up

6 Project Timelines APW by WHO to FIND in Sept, 2011 for 2 Study year project conceived, funding approved by USAID March, 2010 Protocol approved and 18 projects sites finalized by NTP, Jan, 2012 Ethical approval, 10 th March, 2012 First site operational, 24 March, 2012

7 Project design Project sites Unit of implementation: RNTCP TB Unit- Approx. 500,000 population 18 TB Units identified by programme at Diverse settings; Pop.8.7 million Baseline Data collection: 2-3 months for 14 sites Four sites directly started CBNAAT for early feasibility assessment Preparatory activities Training Referral linkages with all public health facilities Air Cond, Power Back-up, security aspects addressed Intervention Same day sputum specimen transportation All pulmonary TB & DR TB suspects offered single CBNAAT test Rx based on CBNAAT result CBNAAT-detected RIF-resistant patients referred for 2 nd line treatment; specimen sent to reference lab for confirmatory DST

8 All project sites provided with: Air-conditioning Preparatory Activities 2 hours power back-up for CBNAAT equipment Maximum and Minimum temperature gauges Training Existing staff used to operate CBNAAT One day to lab staff on CBNAAT testing & to field staff on project protocol Specimen transportation Specific specimen transportation mechanism developed for each site Transportation cost covered under the project Quality assurance Panel testing using GLI Xpert MTB-Rif panel

9 Rapid Scale Up 7000 Total monthly TB suspects tested across sites sites sites sites sites sites sites sites sites sites sites March April May June July August September October November December

10 Impact Results- Case detection Comparison with Baseline Baseline phase 10,841 TB suspects tested Average 241 TB suspects/month/site Intervention with CBNAAT 34,896 TB suspects tested Average of 265 TB suspects/month/site Average increase of 15% per site 1555 Microbiologically confirmed TB cases detected 14.3% smear positivity Average of 35 TB cases/month/site 7210 CBNAAT MTB positive cases detected 20.7% CBNAAT positivity Average of 55 TB cases/month/site

11 Impact Results- Case detection Comparison with Baseline Baseline Intervention Average TB suspects per month Average microbiologically confirmed TB cases per month

12 Impact Results- Case detection Comparison with Sm. Microscopy results in Intervention phase March to Dec, 12 34,896 TB suspects tested on CBNAAT 7210 CBNAAT MTB positive cases detected 20.7% positivity 4717 were smear positive 13.5 % positivity (7.2%) Additional 0 microbiologically confirmed cases detected 689 TB cases found Rif resistant CBNAAT Positive Smear Positive Rif Resistant CBNAAT additional contribution of microbiologically-confirmed cases and DR-TB cases

13 Impact Results Detection of Rif Resistance-TB Baseline data collection DST offered to all identified DR-TB suspects Total 238 DR-TB suspects identified under the programme 23 diagnosed with Rif Resistance-TB; Intervention phase CBNAAT test offered to all TB & DR-TB suspects in project Total 35,358 TB & DR-TB suspects tested (34,896TB suspects & 462 DR- TB suspects) 797 cases diagnosed with Rif Resistance-TB; 689 among TB suspects & 108 among DR-TB suspects

14 Interim Conclusions Testing all TB suspects using CBNAAT increased detection of microbiologically-confirmed TB and Rif Resistance-TB Significant increase in microbiologically-confirmed TB cases Significant increase in Rif Resistance-TB detection over baseline CBNAAT can be feasibly deployed at this decentralized level for all suspects in diverse settings in India Deployed at 18 public health clinics, doing 5000 tests per month with minimally-modified infrastructure and human resources 93% of patients with interpretable result from first test; 99% with repeat testing. With A/C availability, temperature errors negligible

15 Objectives EXPANDx TB CBNAAT project Establish 12 CBNAAT labs for Rif DST to supplement the efforts and capacity of the existing reference lab network of RNTCP Introduce CBNAAT at ICELT, NTI, Bangalore Thereby address the national training needs for CBNAAT Expected Outcome Further strengthen RNTCP by providing access to rapid DST in hard to reach areas Conduct more than Rapid DSTs across the 12 CBNAAT labs; Detect approx 7000 DR-TB cases, annually 15

16 Project design Project sites Decentralised labs to provide DST to a number districts Total 100 Districts covered; 168 Million Preparatory activities Training Referral linkages with all coverage districts Air Cond, Power Back-up, security aspects addressed Activity Specimen of DR-TB suspects transported from each district to CBNAAT lab for DST Transportation of sputum specimen to CBNAAT lab on transportation within 48 hours Same day testing Communication of results by SMS & on the same day

17 Current status S. No State Sites Functional status 1 Andhra Pradesh Medak 01 August Gujarat Surat 01 August Tamil Nadu Madurai 01 August Nagaland Kohima 8 August J& K Srinagar 28 August Punjab Patiala 24 August Uttar Pradesh Varanasi 10 January Uttar Pradesh Allahabad 11 January Karnataka NTI Bangalore 17 Sept Karnataka ICELT (training) 18 Sept Maharashtra Govandi, Mumbai 09 March Tamil Nadu CMC, Vellore 04 December Maharashtra B. J. medical College, Pune Site assessment done 14 Sikkim Gangtok Pending

18 Scale up under the project Q12 4Q12 1Q13 2Q13 3Q13 4Q13 DR-TB suspects Rif Resistant

19 Acknowledgements Dr. Ashok Kumar, Dr Neeraj Raizada Dr. Sreenivas Dr. Catharina Boehme Dr. Param & Dr. Bala Project Coordinators- Dr. Bhavin, Dr. Shubhangi and Dr. Ameet Dr. Puneet Dewan Dr. Malik Parmar & Dr. Mayank, CTD Dr. Ranjani State and District RNTCP officials All RNTCP Consultants

20 THANKS

India s Contribution in Rolling out Newer and Rapid Diagnostics towards PMDT Scale-up

India s Contribution in Rolling out Newer and Rapid Diagnostics towards PMDT Scale-up India s Contribution in Rolling out Newer and Rapid Diagnostics towards PMDT Scale-up Balasangameshwara Vollepore, FIND (India) FIND and Partners Symposium 43 rd Union World Conference on Lung Health November

More information

Tuberculosis-HIV epidemic situation and emerging challenges in North India

Tuberculosis-HIV epidemic situation and emerging challenges in North India NTI Bulletin 2015,51 /1&4, 1 7 Tuberculosis-HIV epidemic situation and emerging challenges in North India Rajesh Deshmukh 1,3, Raghu Ram Rao 2, Shah A 2,3, Sreenivas A Nair 3, R S Gupta 1, SD Khaparde

More information

Implementation and scale-up of the Xpert MTB/RIF system for rapid diagnosis of TB and MDR-TB. Global Consultation

Implementation and scale-up of the Xpert MTB/RIF system for rapid diagnosis of TB and MDR-TB. Global Consultation Implementation and scale-up of the Xpert MTB/RIF system for rapid diagnosis of TB and MDR-TB Global Consultation Geneva, 30 November 2010 Mario C. Raviglione, M.D. Director, Stop TB Department WHO, Geneva,

More information

Xpert MTB/RIF use for TB diagnosis in TB suspects with no significant risk of drug resistance or HIV infection. Results of Group Work

Xpert MTB/RIF use for TB diagnosis in TB suspects with no significant risk of drug resistance or HIV infection. Results of Group Work Xpert MTB/RIF use for TB diagnosis in TB suspects with no significant risk of drug resistance or HIV infection Results of Group Work DOTS expansion and enhancement Objective This group deals with the majority

More information

Delivering Integrated HIV/TB Services in India: Challenges and Opportunities in National AIDS Control Program (NACP) IV.

Delivering Integrated HIV/TB Services in India: Challenges and Opportunities in National AIDS Control Program (NACP) IV. Delivering Integrated HIV/TB Services in India: Challenges and Opportunities in National AIDS Control Program (NACP) IV. Introduction: Deshmukh Rajesh 1 Ashok Kumar 1 K.S.Sachdeva 2 Amar Shah 2 India is

More information

Briefing on Intensified Malaria Control Project-3 (IMCP-3)

Briefing on Intensified Malaria Control Project-3 (IMCP-3) Briefing on Intensified Malaria Control Project-3 (IMCP-3) India CCM Induction and Orientation Workshop 3 rd -4 th December 2015 Directorate of National Vector Borne Diseases Control Programme, Delhi Plan

More information

Challenges in Scaling-up TB/HIV collaborative activities in a diverse HIV epidemic -India

Challenges in Scaling-up TB/HIV collaborative activities in a diverse HIV epidemic -India Challenges in Scaling-up TB/HIV collaborative activities in a diverse HIV epidemic -India Dr. B. B. Rewari WHO National Consultant National Programme Officer (ART) National AIDS Control Organisation New

More information

National Family Health Survey (NFHS-3) HIV Knowledge and Prevalence

National Family Health Survey (NFHS-3) HIV Knowledge and Prevalence 2005-06 National Family Health Survey (NFHS-3) HIV Knowledge and Prevalence Contents HIV/AIDS Knowledge Family Life Education The How of HIV Testing Coverage of HIV Testing in NFHS-3 HIV prevalence Knowledge

More information

International Journal of Health Sciences and Research ISSN:

International Journal of Health Sciences and Research  ISSN: International Journal of Health Sciences and Research www.ijhsr.org ISSN: 2249-9571 Short Communication Awareness of Medical Interns Regarding Recent Guidelines of Revised National Tuberculosis Control

More information

Progress Report March 2016

Progress Report March 2016 Progress Report March 2016 Table of Contents Background to project 3 Assays performed to date 3 Correctional Services 5 Peri-Mining 6 Rif Concordance 7 Training: Laboratory and Clinical 7 Challenges identified

More information

Department Of AIDS Control (DAC) Ministry of Health and Family Welfare, GOI Chandralok Building, 36 - Janpath, New Delhi

Department Of AIDS Control (DAC) Ministry of Health and Family Welfare, GOI Chandralok Building, 36 - Janpath, New Delhi Department Of AIDS Control () Ministry of Health and Family Welfare, GOI Chandralok Building, 36 - Janpath, New Delhi - 110001 Minutes of Meeting of National TB/HIV Co-ordination Committee (NTCC) held

More information

Diagnosis of Extra Pulmonary Tuberculosis By Using Xpert MTB/RIF Assay (CBNAAT) And MGIT Liquid Culture.

Diagnosis of Extra Pulmonary Tuberculosis By Using Xpert MTB/RIF Assay (CBNAAT) And MGIT Liquid Culture. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-issn: 2279-0853, p-issn: 2279-0861.Volume 17, Issue 9 Ver. 10 (September. 2018), PP 65-70 www.iosrjournals.org Diagnosis of Extra Pulmonary Tuberculosis

More information

Performance of RNTCP NTI Bulletin 2005,41/3&4,

Performance of RNTCP NTI Bulletin 2005,41/3&4, Performance of RNTCP NTI Bulletin 2005,41/3&4, 118-122 A Cohort Analysis of Performance of RNTCP in MS Subramanya Rao*, KP Unnikrishnan**, MA Sharada BACKGROUND Tuberculosis (TB) is one of the most serious

More information

Assessing the programmatic management of drug-resistant TB

Assessing the programmatic management of drug-resistant TB Assessing the programmatic management of drug-resistant TB a. Review the programmatic management of drug-resistant TB patients with the TB manager. i. What is the size of MDR-TB problem locally? How many

More information

Heather Alexander, PhD

Heather Alexander, PhD Xpert MTB/RIF: An Opportunity to Strengthen Laboratory Systems and Bridge the Laboratory-Program Gap Heather Alexander, PhD International Laboratory Branch Division of Global HIV/AIDS Centers for Disease

More information

The Lancet Infectious Diseases

The Lancet Infectious Diseases Xpert MTB/RIF Ultra for detection of Mycobacterium tuberculosis and rifampicin resistance: a prospective multicentre diagnostic accuracy study Susan E Dorman, Samuel G Schumacher, David Alland et al. 2017

More information

Role of RNTCP in the management MDR-TB

Role of RNTCP in the management MDR-TB Kamdar DJ, Shah NA, Patel DJ, Parmarr H. Role of RNTCP in the management of MDR-TB. IAIM, 2015; 2(7): 1-5. Original Research Article Role of RNTCP in the management of MDR-TB Deepali J Kamdar 1, Neha A

More information

National Xpert MTB/RIF Programme

National Xpert MTB/RIF Programme National Xpert MTB/RIF Programme 1. Background to Project This project was initiated at the request of the Honorable Minister of Health, Dr Aaron Motsoaledi, in early 2011, following the World Health Organization

More information

How best to structure a laboratory network with new technologies

How best to structure a laboratory network with new technologies How best to structure a laboratory network with new technologies Cristina Gutierrez, MD, PhD Uniting to scale up TB care in Central Asia 14 and 15 April 2011 Tashkent, Uzbekistan New laboratory diagnostics

More information

Revised National Tuberculosis Control Programme (RNTCP) Dr.Kishore Yadav J Assistant Professor

Revised National Tuberculosis Control Programme (RNTCP) Dr.Kishore Yadav J Assistant Professor Revised National Tuberculosis Control Programme (RNTCP) Dr.Kishore Yadav J Assistant Professor Global scenario*: Burden of TB Incidence : 9.6 million (58% SEAR and Western Pacific) Deaths : 1.5 million

More information

TUBERCULOSIS IN THE SAARC REGION AN UPDATE 2006

TUBERCULOSIS IN THE SAARC REGION AN UPDATE 2006 SAARC Tuberculosis and HIV/AIDS Centre TUBERCULOSIS IN THE SAARC REGION AN UPDATE 2006 SAARC Tuberculosis & HIV/AIDS Centre (STC) P. O. Box No. 9517, Kathmandu, Nepal Thimi, Bhaktapur Tel: 6631048, 6632477,

More information

Ministry of Health. National Tuberculosis Control Program INTEGRATED TB HIV PROGRAM REPORT (JANUARY JUNE 2015)

Ministry of Health. National Tuberculosis Control Program INTEGRATED TB HIV PROGRAM REPORT (JANUARY JUNE 2015) Ministry of Health National Tuberculosis Control Program INTEGRATED TB HIV PROGRAM REPORT (JANUARY JUNE 2015) Contents Executive summary... 2 Background... 3 National Tuberculosis Program Overview... 3

More information

Xpert MTB/RIF assay validation experience --- impact and plan in China

Xpert MTB/RIF assay validation experience --- impact and plan in China Xpert MTB/RIF assay validation experience --- impact and plan in China Dr. Zhao Yanlin Chinese Center for Disease Control & Prevention Dr. Richard O Brien FIND April. 16, 2013 Progress Contribution for

More information

Revised National Tuberculosis Control Programme

Revised National Tuberculosis Control Programme Revised National Tuberculosis Control Programme 1 OUTLINE OF PRESENTATION Introduction Burden Of The Disease Evolution Of RNTCP Goals And Objectives Of RNTCP DOTS Stop TB Strategy Organization RNTCP Endorsed

More information

MDR, XDR and Untreatable Tuberculosis and Laboratory Perspectives. Martie van der Walt TUBERCULOSIS EPIDEMIOLOGY & INTERVENTION RESEARCH UNIT

MDR, XDR and Untreatable Tuberculosis and Laboratory Perspectives. Martie van der Walt TUBERCULOSIS EPIDEMIOLOGY & INTERVENTION RESEARCH UNIT TUBERCULOSIS EPIDEMIOLOGY & INTERVENTION RESEARCH UNIT MDR, XDR and Untreatable Tuberculosis and Laboratory Perspectives Martie van der Walt IOM Meeting 15-17 January 2013 introduction 1 min 150 words

More information

Overview of Drug Resistant TB in India and National Scale up of MDR TB Diagnosis and Treatment

Overview of Drug Resistant TB in India and National Scale up of MDR TB Diagnosis and Treatment Overview of Drug Resistant TB in India and National Scale up of MDR TB Diagnosis and Treatment Dr. K S Sachdeva Chief Medical Officer TB (SAG) Central TB Division DGHS, MoHFW, GoI New Delhi Facing the

More information

PROJECT AXSHYA COMMUNITY ENGAGEMENT in TB CARE

PROJECT AXSHYA COMMUNITY ENGAGEMENT in TB CARE PROJECT AXSHYA COMMUNITY ENGAGEMENT in TB CARE An NGO-consortium initiative by World Vision India & Partners 4 th Dec 15 CSOs TB Project supported by The GFATM Round 9 grant PR: World Vision India SRs:

More information

Haryana-06 Delhi-07 Total disabled population Persons 455, , , ,886 13, ,454 Males 273, ,908 68, ,872 8, ,44

Haryana-06 Delhi-07 Total disabled population Persons 455, , , ,886 13, ,454 Males 273, ,908 68, ,872 8, ,44 INDIA-00 Jammu & Kashmir-01 Total disabled population Persons 21,906,769 16,388,382 5,518,387 302,670 229,718 72,952 Males 12,605,635 9,410,185 3,195,450 171,816 129,443 42,373 Females 9,301,134 6,978,197

More information

Diagnosing Xpert MTB/RIF negative TB suspects: Impact and cost of an alternative algorithm

Diagnosing Xpert MTB/RIF negative TB suspects: Impact and cost of an alternative algorithm Diagnosing Xpert MTB/RIF negative TB suspects: Impact and cost of an alternative algorithm Kathryn Schnippel 1, Gesine Meyer-Rath 1,2, Lawrence Long 1, Wendy Stevens 3,4, Ian Sanne 1,2, and Sydney Rosen

More information

Scaling up of collaborative TB/HIV activities in concentrated HIV epidemic settings. A case study from India

Scaling up of collaborative TB/HIV activities in concentrated HIV epidemic settings. A case study from India Scaling up of collaborative TB/HIV activities in concentrated HIV epidemic settings A case study from India WHO Library Cataloguing-in-Publication Data Scaling up of collaborative TB/HIV activities in

More information

Integrated, Patient Centred Model of HIV- TB Care and Prevention: India Case Study

Integrated, Patient Centred Model of HIV- TB Care and Prevention: India Case Study IPC Model of HIV-TB Integrated, Patient Centred Model of HIV- TB Care and Prevention: India Case Study RD Deshmukh 1, K.S. Sachdeva 2 Tuberculosis (TB) and Human Immunodeficiency virus (HIV) remain public

More information

Dr Richard Christopher,(Pediatrician) Ministry of Health and Social Welfare NTLP- TANZANIA Tanzania. Childhood TB Roadmap Paris 0ctober 29

Dr Richard Christopher,(Pediatrician) Ministry of Health and Social Welfare NTLP- TANZANIA Tanzania. Childhood TB Roadmap Paris 0ctober 29 Dr Richard Christopher,(Pediatrician) Ministry of Health and Social Welfare NTLP- TANZANIA Tanzania Childhood TB Roadmap Paris 0ctober 29 Status of childhood TB in Tanzania Child TB linkages with National

More information

Xpert MTB/Rif What place for TB diagnosis in MSF projects? Francis Varaine, MSF Geneva, 29/11/10

Xpert MTB/Rif What place for TB diagnosis in MSF projects? Francis Varaine, MSF Geneva, 29/11/10 Xpert MTB/Rif What place for TB diagnosis in MSF projects? Francis Varaine, MSF Geneva, 29/11/10 Introduction Excellent performances, rapid results, and easy to use Questions Where and how are we going

More information

Outcome Results of Programmatic Management of Drug Resistant Tuberculosis in 84 Patients From North Coastal Andhra Pradesh

Outcome Results of Programmatic Management of Drug Resistant Tuberculosis in 84 Patients From North Coastal Andhra Pradesh Original Article Outcome Results of Programmatic Management of Drug Resistant Tuberculosis in 84 Patients From North Coastal Andhra Pradesh Usharani Namballa 1, Sambasiva Rao Gorantla 2, Sushmitha Jakka

More information

Multidrug-Resistant TB

Multidrug-Resistant TB Multidrug-Resistant TB Diagnosis Treatment Linking Diagnosis and Treatment Charles L. Daley, M.D. National Jewish Health University of Colorado Denver Disclosures Chair, Data Monitoring Committee for delamanid

More information

: uptake and impact of Xpert MTB/RIF

: uptake and impact of Xpert MTB/RIF Photo: Riccardo Venturi 21-215: uptake and impact of Xpert MTB/RIF Wayne van Gemert WHO Global TB Programme, Geneva Joint Partners Forum for Strengthening and Aligning TB Diagnosis and Treatment 27-3 April

More information

TB-HIV in the South-East Asia Region

TB-HIV in the South-East Asia Region TB-HIV in the South-East Asia Region 13 th Core Group Meeting of the TB/HIV Working Group April 17-18 New York, USA Dr Nani Nair Regional Advisor-TB TB and HIV in South-East Asia Outline Epidemiology of

More information

Definitions and reporting framework for tuberculosis 2013 revision. Dennis Falzon Global Forum of Xpert MTB/RIF Implementers Annecy 17 April 2013

Definitions and reporting framework for tuberculosis 2013 revision. Dennis Falzon Global Forum of Xpert MTB/RIF Implementers Annecy 17 April 2013 Definitions and reporting framework for tuberculosis 2013 revision Dennis Falzon Global Forum of Xpert MTB/RIF Implementers Annecy 17 April 2013 2-year revision process WHO/HTM/TB/2013.2 2 www.who.int/iris/bitstream/10665/79199/1/9789241505345_eng.pdf

More information

Let s Talk TB A Series on Tuberculosis, A Disease That Affects Over 2 Million Indians Every Year

Let s Talk TB A Series on Tuberculosis, A Disease That Affects Over 2 Million Indians Every Year Let s Talk TB A Series on Tuberculosis, A Disease That Affects Over 2 Million Indians Every Year Lancelot M. Pinto, MD, MSc Author Madhukar Pai, MD, PhD co-author and Series Editor Lancelot Pinto is a

More information

Guidance on Matching Funds: Tuberculosis Finding the Missing People with TB

Guidance on Matching Funds: Tuberculosis Finding the Missing People with TB February 2017 Guidance on Matching Funds: Tuberculosis Finding the Missing People with TB 1. Background TB is the leading cause of death by infectious disease, killing 1.8 million people in 2015. Each

More information

ASSESSMENT OF GENE-XPERT MTB RIF PROGRAM IMPLEMENTATION AND THE CHALLENGES FOR ENHANCED TUBERCULOSIS DIAGNOSIS IN NIGERIA

ASSESSMENT OF GENE-XPERT MTB RIF PROGRAM IMPLEMENTATION AND THE CHALLENGES FOR ENHANCED TUBERCULOSIS DIAGNOSIS IN NIGERIA SAARC Journal of Tuberculosis, Lung Diseases & HIV/AIDS ASSESSMENT OF GENE-XPERT MTB RIF PROGRAM IMPLEMENTATION AND THE CHALLENGES FOR ENHANCED TUBERCULOSIS DIAGNOSIS IN NIGERIA Mustapha G 1, Jumoke O

More information

A pilot study measuring the kinetic profile of IP-10 over the first 14 days of PTB chemotherapy

A pilot study measuring the kinetic profile of IP-10 over the first 14 days of PTB chemotherapy A pilot study measuring the kinetic profile of IP-10 over the first 14 days of PTB chemotherapy Dr Rachel Saunders Dr Matthew Blakiston Liverpool School of Tropical Medicine Background TB is responsible

More information

- UPDATE - Implementation and roll-out of Xpert MTB/RIF October 2011

- UPDATE - Implementation and roll-out of Xpert MTB/RIF October 2011 - UPDATE - Implementation and roll-out of Xpert MTB/RIF October 2011 This document provides an update on the global roll-out of Xpert MTB/RIF, the WHO-endorsed test for the rapid and simultaneous detection

More information

PROJECT ŚVETANA (Dawn) Elimination of new HIV infections among children by Scaling up PPTCT services in private health sector

PROJECT ŚVETANA (Dawn) Elimination of new HIV infections among children by Scaling up PPTCT services in private health sector PROJECT ŚVETANA (Dawn) Elimination of new HIV infections among children by Scaling up PPTCT services in private health sector Supported by Global Fund for AIDS, TB and Malaria (GFATM) Oct 2015 Dec 2017

More information

Implementing revised TB/HIV recording and reporting tools Country Experience. Dr Nathan Kapata National TB/ Leprosy Programme Manager

Implementing revised TB/HIV recording and reporting tools Country Experience. Dr Nathan Kapata National TB/ Leprosy Programme Manager Implementing revised TB/HIV recording and reporting tools Country Experience Dr Nathan Kapata National TB/ Leprosy Programme Manager Outline Objective Background Implementation of TB/HIV collaborative

More information

Xpert MTB/RIF rollout; Botswana s experience

Xpert MTB/RIF rollout; Botswana s experience Xpert MTB/RIF rollout; Botswana s experience Team Botswana T Madidimalo; T Bagapi; R T Ncube; E Hulela; S Lanje (11 th April 2013, Maputo) Presentation outline Background context TB/HIV country profile

More information

Let s Talk TB. A Series on Tuberculosis, A Disease That Affects Over 2 Million Indians Every Year

Let s Talk TB. A Series on Tuberculosis, A Disease That Affects Over 2 Million Indians Every Year A Series on Tuberculosis, A Disease That Affects Over 2 Million Indians Every Year Lancelot M. Pinto, MD, MSc Author Madhukar Pai, MD, PhD co-author and Series Editor Abstract Nearly 50% of patients with

More information

TOG The Way Forward

TOG The Way Forward TOG 2016- The Way Forward Main Changes in Diagnostic algorithm Definition (Type, Classification, Outcome) Registration at the time of Diagnosis (PHI level Notification Register) Long term follow up (till

More information

7.5 South-East Asian Region: summary of planned activities, impact and costs

7.5 South-East Asian Region: summary of planned activities, impact and costs PART II: GLOBAL AND REGIONAL SCENARIOS FOR TB CONTROL 26 215 7.5 South-East Asian Region: summary of planned activities, impact and costs Achievements DOTS expanded rapidly in the South-East Asian Region

More information

GOVERNMENT OF INDIA MINISTRY OF HEALTH AND FAMILY WELFARE DEPARTMENT OF HEALTH AND FAMILY WELFARE

GOVERNMENT OF INDIA MINISTRY OF HEALTH AND FAMILY WELFARE DEPARTMENT OF HEALTH AND FAMILY WELFARE GOVERNMENT OF INDIA MINISTRY OF HEALTH AND FAMILY WELFARE DEPARTMENT OF HEALTH AND FAMILY WELFARE 1103. SHRI J.J.T. NATTERJEE: SHRI KANWAR SINGH TANWAR: ADV. JOICE GEORGE: SHRI PANKAJ CHAUDHARY: LOK SABHA

More information

HEALTH ORGANISATIONS. National Health Programme

HEALTH ORGANISATIONS. National Health Programme HEALTH ORGANISATIONS National Health Programme There are various National Health Programmes launched in India to eradicate fatal diseases. National Health Programme launched by Indian government after

More information

India's voice against AIDS. December 2012

India's voice against AIDS. December 2012 India's voice against AIDS December 2012 HIV Sentinel Surveillance 2010-11 A Technical Brief India's voice against AIDS December 2012 Contents Acronyms...4 Executive Summary...5 1. Introduction...8 Objectives

More information

TB Disease Prevalence Survey - Overview and Introduction of the TF

TB Disease Prevalence Survey - Overview and Introduction of the TF TB Disease Prevalence Survey - Overview and Introduction of the TF Ikushi Onozaki MD, MPH Team Leader, TB Prevalence Survey WHO Global Task Force on TB Impact Measurement Stop TB Department, WHO onozakii@who.int

More information

HIV Clinicians Society Conference TB/HIV Treatment Cascade

HIV Clinicians Society Conference TB/HIV Treatment Cascade HIV Clinicians Society Conference-2012 TB/HIV Treatment Cascade Dr Judith Mwansa-Kambafwile Wits Reproductive Health & HIV Institute University of Witwatersrand TB/HIV Treatment Cascade Overview TB stats

More information

HIV Epidemic in India

HIV Epidemic in India HIV Epidemic in India Dr.R.R.Gangakhedkar Head, Division of Epidemiology & Communicable Diseases, Indian Council of Medical Research New Delhi Waves in Spread of HIV Epidemic Core Group Bridge Populationmostly

More information

HIV Seroprevalence among Tuberculosis Patients in India,

HIV Seroprevalence among Tuberculosis Patients in India, HIV Seroprevalence among Tuberculosis Patients in India, 2006 2007 Neeraj Raizada 1, Lakbir Singh Chauhan 2, Ajay Khera 3, Jotna Sokhey 3, D. Fraser Wares 1, Suvanand Sahu 1, Rahul Thakur 1, Puneet Kumar

More information

NATIONAL TUBERCULOSIS PREVALENCE SURVEY 2016

NATIONAL TUBERCULOSIS PREVALENCE SURVEY 2016 NATIONAL TUBERCULOSIS PREVALENCE SURVEY 2016 Department of Health/National TB Control Program Philippine Council for Health Research and Development Foundation for the Advancement of Clinical Epidemiology,

More information

Supplementary webappendix

Supplementary webappendix Supplementary webappendix This webappendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors. Supplement to: Arinaminpathy N, Batra D, Khaparde S,

More information

CBNAAT: A Novel Tool for Rapid Detection of MTB and Rifampicin Resistance

CBNAAT: A Novel Tool for Rapid Detection of MTB and Rifampicin Resistance International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 5 Number 12 (2016) pp. 383-388 Journal homepage: http://www.ijcmas.com Original Research Article http://dx.doi.org/10.20546/ijcmas.2016.512.042

More information

Revitalization of PPFP/PPIUCD Services in India Dr Bulbul Sood Country Director Jhpiego/India

Revitalization of PPFP/PPIUCD Services in India Dr Bulbul Sood Country Director Jhpiego/India Revitalization of PPFP/PPIUCD Services in India Dr Bulbul Sood Country Director Jhpiego/India Family Planning Technical Meeting Women Deliver Conference, Kuala Lumpur, Malaysia 27 May 2013 India Most Populous

More information

TB: A Supplement to GP CLINICS

TB: A Supplement to GP CLINICS TB: A Supplement to GP CLINICS Chapter 4: Improving Access to Affordable and Quality TB Tests in India Authors: Madhukar Pai, MD, PhD Author and Series Editor Tuberculosis Tuberculosis (TB) remains one

More information

Balancing investment in point of care diagnostics versus laboratory testing in low resource settings. June 28, 2011

Balancing investment in point of care diagnostics versus laboratory testing in low resource settings. June 28, 2011 Balancing investment in point of care diagnostics versus laboratory testing in low resource settings Workshop on TB and HIV Diagnostics Workshop on TB and HIV Diagnostics June 28, 2011 Complexity Delivery

More information

Tuberculosis Screening and IPT: Experience from India

Tuberculosis Screening and IPT: Experience from India Tuberculosis Screening and IPT: Experience from India Dr B.B.Rewari WHO National consultant Care, Support and Treatment National Programme Officer (ART) National AIDS Control Organization New Delhi-110001,

More information

Procurement update: StopTB Partnership - Global Drug Facility (GDF)

Procurement update: StopTB Partnership - Global Drug Facility (GDF) Procurement update: StopTB Partnership - Global Drug Facility (GDF) Magali BABALEY Strategic Procurement and Business Intelligence Manager Stop TB Partnership, Global Drug Facility (GDF) team joint UNICEF-UNFPA-WHO

More information

DST for detection of DR TB - roll out of Xpert in South Africa and overview of other technologies: what are the gaps?

DST for detection of DR TB - roll out of Xpert in South Africa and overview of other technologies: what are the gaps? DST for detection of DR TB - roll out of Xpert in South Africa and overview of other technologies: what are the gaps? Mark Nicol Division of Medical Microbiology and Institute for Infectious Diseases and

More information

TB: A Supplement to GP CLINICS

TB: A Supplement to GP CLINICS TB: A Supplement to GP CLINICS Chapter 10: Childhood Tuberculosis: Q&A For Primary Care Physicians Author: Madhukar Pai, MD, PhD Author and Series Editor What is Childhood TB and who is at risk? India

More information

TB Diagnostics: Global Market Analysis and Potential

TB Diagnostics: Global Market Analysis and Potential TB Diagnostics: Global Market Analysis and Potential Madhukar Pai, MD, PhD McGill University, Montreal, Canada madhukar.pai@mcgill.ca September 2012 Market analyses are important and necessary To support

More information

DFID India VAW strategy

DFID India VAW strategy DFID India VAW strategy 1. Catalysis 2. Analysis 3. Strategies Dr Peter Evans, Senior Governance Adviser, DFID India 1 1. Catalysis India s Domestic Violence Act (2005) (some) legal ambiguity cleared up

More information

Experiences in scaling up childhood TB activities- Pakistan

Experiences in scaling up childhood TB activities- Pakistan Experiences in scaling up childhood TB activities- Pakistan Farhana Amanullah Childhood TB subgroup meeting 29 th October, 2013- Paris, France Childhood TB in Pakistan TB Prevalence rate is estimated at

More information

Report on WHO Policy Statements

Report on WHO Policy Statements Report on WHO Policy Statements Christopher Gilpin TB Diagnostics and Laboratory Strengthening Unit Secretariat, Global Laboratory Initiative Stop TB Department, WHO Geneva New Diagnostics Working Group

More information

MEASURE TO IMPROVE DETECTON OF SMEAR POSITIVE CASES UNDER RNTCP: COMPARISION OF COUGH 2WEEKS VS 3 WEEKS

MEASURE TO IMPROVE DETECTON OF SMEAR POSITIVE CASES UNDER RNTCP: COMPARISION OF COUGH 2WEEKS VS 3 WEEKS Original Article MEASURE TO IMPROVE DETECTON OF SMEAR POSITIVE CASES UNDER RNTCP: COMPARISION OF COUGH 2WEEKS VS 3 WEEKS Parmar Rahul 1, Baxi R K 2 1. Assistant Professor, Baroda Medical College 2. Professor,

More information

The Western Pacific Region faces significant

The Western Pacific Region faces significant COMBATING COMMUNICABLE DISEASES A medical technician draws blood for HIV screening in Manila. AFP elimination of mother-to-child transmission of HIV and congenital syphilis was piloted in Malaysia and

More information

Let s Talk TB A Series on Tuberculosis, A Disease That Affects Over 2 Million Indians Every Year

Let s Talk TB A Series on Tuberculosis, A Disease That Affects Over 2 Million Indians Every Year A Series on Tuberculosis, A Disease That Affects Over 2 Million Indians Every Year Madhukar Pai, MD, PhD Author and Series Editor Camilla Rodrigues, MD co-author Abstract Most individuals who get exposed

More information

Ramesh P. M.*, Saravanan M.

Ramesh P. M.*, Saravanan M. International Journal of Advances in Medicine Ramesh PM et al. Int J Adv Med. 2018 Jun;5(3):561-565 http://www.ijmedicine.com pissn 2349-3925 eissn 2349-3933 Original Research Article DOI: http://dx.doi.org/10.18203/2349-3933.ijam20181663

More information

POSITIONING OF TB DX : TIERED SYSTEM, INTEGRATED APPROACH

POSITIONING OF TB DX : TIERED SYSTEM, INTEGRATED APPROACH POSITIONING OF TB DX : TIERED SYSTEM, INTEGRATED APPROACH Akos Somoskövi, M.D., Ph.D. and Giorgio Roscigno, M.D. ANNUAL GLI MEETING, 4 th OCTOBER 2010 MERIEUX FOUNDATION, ANNECY Integrated Laboratory Network

More information

Target product profiles for next generation TB diagnostics. Claudia Denkinger, MD PhD MSc Head of TB, FIND

Target product profiles for next generation TB diagnostics. Claudia Denkinger, MD PhD MSc Head of TB, FIND Target product profiles for next generation TB diagnostics Claudia Denkinger, MD PhD MSc Head of TB, FIND 29 th October 2014 The Global TB Epidemic Undiagnosed TB Undiagnosed TB Facts: 9 million TB cases

More information

Tuberculosis Control. in the South-East Asia Region

Tuberculosis Control. in the South-East Asia Region 2005 Tuberculosis Control in the South-East Asia Region SEA-TB-282 Tuberculosis Control in the South-East Asia Region The Regional Report: 2005 WHO Project No: ICP TUB 001 World Health Organization This

More information

Ram Sharan Gopali (MPH) Executive Director

Ram Sharan Gopali (MPH) Executive Director Ram Sharan Gopali (MPH) Executive Director Basic Facts of Nepal Nepal is a landlocked country located in the WHO Asian region at the edge of the Himalaya between India and the Peoples Republic of China

More information

International Journal of Health Sciences and Research ISSN:

International Journal of Health Sciences and Research  ISSN: International Journal of Health Sciences and Research www.ijhsr.org ISSN: 2249-9571 Short Communication First Line Drug Resistance Study in Pulmonary Tuberculosis Patients from Prakasini Satapathy 1, Bairagi

More information

Improving the estimation of the tuberculosis burden in India

Improving the estimation of the tuberculosis burden in India Krycia Cowling et al. Tuberculosis estimation in India This online first version has been peer-reviewed, accepted and edited, but not formatted and finalized with corrections from authors and proofreaders.

More information

OUT OF STEP DEADLY IMPLEMENTATION GAPS IN THE TB RESPONSE. A survey of TB diagnostic and treatment practices in eight countries.

OUT OF STEP DEADLY IMPLEMENTATION GAPS IN THE TB RESPONSE. A survey of TB diagnostic and treatment practices in eight countries. OUT OF STEP DEADLY IMPLEMENTATION GAPS IN THE TB RESPONSE A survey of TB diagnostic and treatment practices in eight countries October 2014 www.msfaccess.org ABOUT MÉDECINS SANS FRONTIÈRES (MSF) MSF is

More information

REACHING PRIMARY HEALTH SERVICES FOR THE URBAN POOR: LESSONS FROM INDIA URBAN SLUMS PROJECT

REACHING PRIMARY HEALTH SERVICES FOR THE URBAN POOR: LESSONS FROM INDIA URBAN SLUMS PROJECT REACHING PRIMARY HEALTH SERVICES FOR THE URBAN POOR: LESSONS FROM INDIA URBAN SLUMS PROJECT G. N. V. Ramana, Sr. Public Health Specialist Elizabeth Lule, Population & Reproductive Health Advisor The World

More information

Background paper number 7

Background paper number 7 Background paper number 7 Lessons learnt and policy implications from recently completed TB disease prevalence surveys and their interpretation - Vietnam Binh Hoa Nguyen Prevalence survey in Vietnam 2006-2007

More information

Rapid PCR TB Testing Results in 68.5% Reduction in Unnecessary Isolation Days in Smear Positive Patients.

Rapid PCR TB Testing Results in 68.5% Reduction in Unnecessary Isolation Days in Smear Positive Patients. Rapid PCR TB Testing Results in 68.5% Reduction in Unnecessary Isolation Days in Smear Positive Patients. Item Type Thesis Authors Patel, Ravikumar Publisher The University of Arizona. Rights Copyright

More information

Overview of the Presentation

Overview of the Presentation Overview of the Presentation Definitions(TBCase, MDR-TB & XDR-TB) Global Tuberculosis (TB,HIV/TB,MDR & XDR)Scenario & Trend Risk factor for TB Natural history of TB Types of TB & Trends of Extra Pulmonary

More information

PREVENTION AND EARLY DETECTION OF CANCER. Will the Minister of HEALTH AND FAMILY WELFARE be pleased to state:

PREVENTION AND EARLY DETECTION OF CANCER. Will the Minister of HEALTH AND FAMILY WELFARE be pleased to state: GOVERNMENT OF INDIA MINISTRY OF HEALTH AND FAMILY WELFARE DEPARTMENT OF HEALTH AND FAMILY WELFARE LOK SABHA UNSTARRED QUESTION NO. 2212 TO BE ANSWERED ON 28 TH JULY, 2017 PREVENTION AND EARLY DETECTION

More information

6.10. NUTRITIONAL STATUS OF TRIBAL POPULATION

6.10. NUTRITIONAL STATUS OF TRIBAL POPULATION 6.1. NUTRITIONAL STATUS OF TRIBAL POPULATION The tribal populations are is recognised as socially and economically vulnerable. Their lifestyles and food habits are different from that of their rural neighbours.

More information

7.10. NUTRITIONAL STATUS OF TRIBAL POPULATION

7.10. NUTRITIONAL STATUS OF TRIBAL POPULATION 7.1. NUTRITIONAL STATUS OF TRIBAL POPULATION The tribal populations are is recognised as socially and economically vulnerable. Their lifestyles and food habits are different from that of their rural neighbours.

More information

National TB Prevalence survey in Myanmar. By Dr. Thandar Lwin Programme Manager National TB Programme Department of Health

National TB Prevalence survey in Myanmar. By Dr. Thandar Lwin Programme Manager National TB Programme Department of Health National TB Prevalence survey in Myanmar By Dr. Thandar Lwin Programme Manager National TB Programme Department of Health 58 million pop. 676,577 sq km (75/sq km) S+ notification rate/100,000 population

More information

TB/HIV 2 sides of the same coin. Dr. Shamma Shetye, MD Microbiology Metropolis Healthcare, Mumbai

TB/HIV 2 sides of the same coin. Dr. Shamma Shetye, MD Microbiology Metropolis Healthcare, Mumbai TB/HIV 2 sides of the same coin Dr. Shamma Shetye, MD Microbiology Metropolis Healthcare, Mumbai Global- Tb new cases Diagnosis-Microscopy ZN,Flourescent microscopy(fm) Rapid, inexpensive test Specificity>95%

More information

A I D S E p I D E m I c u p D A t E a S I a ASIA china India

A I D S E p I D E m I c u p D A t E a S I a ASIA china India ASIA In Asia, national HIV prevalence is highest in South-East Asia, with wide variation in epidemic trends between different countries. While the epidemics in Cambodia, Myanmar and Thailand all show declines

More information

Table 1: Basic information ,000, (per 1,000 LB) 34.6 (per 1,000 LB) 174 (per 100,000 LB) District 712.

Table 1: Basic information ,000, (per 1,000 LB) 34.6 (per 1,000 LB) 174 (per 100,000 LB) District 712. EPI history EPI launched in 978 with DPT, OPV, BCG and typhoid vaccines TT immunization of pregnant women introduced in 983 MCV introduced in 985 HepB piloted in 00 and made universal in 0 MCV introduced

More information

Role of gene Xpert MTB/RIF in diagnosis of Extrapulmonary Tuberculosis at Government Medical College, Amritsar

Role of gene Xpert MTB/RIF in diagnosis of Extrapulmonary Tuberculosis at Government Medical College, Amritsar International Journal of Current Research in Medical Sciences ISSN: 2454-5716 P-ISJN: A4372-3064, E -ISJN: A4372-3061 www.ijcrims.com Original Research Article Volume 4, Issue 3-2018 DOI: http://dx.doi.org/10.22192/ijcrms.2018.04.03.017

More information

Diagnosis of HIV-Associated Tuberculosis

Diagnosis of HIV-Associated Tuberculosis Diagnosis of HIV-Associated Tuberculosis Stephen D. Lawn Desmond Tutu HIV Centre Institute of Infectious Disease and Molecular Medicine University of Cape Town Dept. Of Clinical Research, Faculty of Infectious

More information

Virtual Implementation Evaluation of Tuberculosis diagnostics in Tanzania Ivor Langley, Liverpool School of Tropical Medicine

Virtual Implementation Evaluation of Tuberculosis diagnostics in Tanzania Ivor Langley, Liverpool School of Tropical Medicine Virtual Implementation Evaluation of Tuberculosis diagnostics in Tanzania Ivor Langley, Liverpool School of Tropical Medicine 3rd sector OR and developing countries 27th March 2013, London School of Economics

More information

Off the Beaten Track: Avahan s Experience in the Business of HIV Prevention among India s Long-Distance Truckers

Off the Beaten Track: Avahan s Experience in the Business of HIV Prevention among India s Long-Distance Truckers Publications from Avahan in this series Avahan The India AIDS Initiative: The Business of HIV Prevention at Scale Off the Beaten Track: Avahan s Experience in the Business of HIV Prevention among India

More information

TB Disease Prevalence Survey - Overview, why and how

TB Disease Prevalence Survey - Overview, why and how TB Disease Prevalence Survey - Overview, why and how Ikushi Onozaki MD, MPH Team Leader, TB Prevalence Survey WHO Global Task Force on TB Impact Measurement Stop TB Department, WHO onozakii@who.int 3 strategic

More information

Global call for action to ensure universal access to malaria diagnosis and treatment

Global call for action to ensure universal access to malaria diagnosis and treatment Global call for action to ensure universal access to malaria diagnosis and treatment Joint activity of SEE Team and PDT Unit Andrea Bosman and Richard Cibulskis Outline of the presentation Background Objectives

More information

was found in Chennai in 1986, India has had an AIDS epidemic. 1 In many respects, however, its extent and complexities have only recently begun

was found in Chennai in 1986, India has had an AIDS epidemic. 1 In many respects, however, its extent and complexities have only recently begun The NEW ENGLA ND JOURNAL of MEDICINE Perspective march 15, 2007 Robert Steinbrook, M.D. Since the human immunodeficiency virus (HIV) was found in Chennai in 1986, India has had an AIDS epidemic. 1 In many

More information

Unified Xpert MTB/RIF Forecasting Initiative

Unified Xpert MTB/RIF Forecasting Initiative Photo: Riccardo Venturi Unified Xpert MTB/RIF Forecasting Initiative Wayne van Gemert WHO Global TB Programme, Geneva WHO ANNUAL MEETING WITH HIV DIAGNOSTIC MANUFACTURERS AND STAKEHOLDERS 11 March 2016

More information