Table Of Contents Executive Summary Introduction to Vaccines Pediatric Preventive Vaccines

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1 Table Of Contents Executive Summary THE GLOBAL VACCINES INDUSTRY Scope and Methodology Overview Pediatric Preventative Vaccines THE MARKET Adult Preventative Vaccines THE MARKET TOTAL MARKET ISSUES AND TRENDS Introduction to Vaccines THE IMMUNE RESPONSE MECHANISM OF ACTION (Table) Impact of Vaccines in the 20th Century Annual Morbidity in the 20th Century vs 2011 A BRIEF HISTORY: THE DEVELOPMENT OF VACCINES TYPES OF VACCINES Attenuated (Weakened) Live Viruses (Table) Vaccine-Preventable Diseases, August 2012 Killed (Inactivated) Viruses Toxoid Vaccines Genetically Engineered/Modified Vaccines VACCINE APPROVAL PROCESS (Table) VAERS Table of Reportable Events Following Vaccination Pediatric Preventive Vaccines INTRODUCTION (Table) Global Immunization Rates by Vaccine Type 2010 CHILDHOOD IMMUNIZATION IN THE UNITED STATES (Table) Immunization Profile of the United States: Population by Age Group, Number of Vaccine-Preventable Diseases Reported by Disease Childhood Immunization Rates Challenges to the Vaccine Delivery System The Effect of U.S. Healthcare Reform Recommended Childhood Immunization Schedule (Table) U.S. Recommended Immunization Schedule for Children Ages 0 Through 6 Years, 2012 (Table) U.S. Recommended Immunization Schedule for Adolescents Ages 7 to 18 Years, 2012 State Immunization Recommendations United Nations Initiatives PEDIATRIC VACCINE PRODUCTS BCG Diphtheria, Tetanus, Pertussis, Hepatitis B and Polio Haemophilus Influenzae Type B Hepatitis A

2 Measles, Mumps and Rubella Meningococcal Disease Pneumococcal Conjugate Rotavirus Varicella PEDIATRIC VACCINES IN DEVELOPMENT COST OF VACCINES IN THE UNITED STATES (Table) Selected Pediatric Vaccines in Development, August 2012 THEWORLD MARKET FOR PEDIATRIC PREVENTIVE VACCINES Total Market Size and Forecast (Table) World Market for Pediatric Vaccines by Type (DTaP/DTP, Hep, HiB, MMR, Combinations, Pneumococcal, Polio, Varicella, Others) Revenues (in millions) (Table) World Market for Pediatric Vaccines by Region (U.S., North America, South America, EU, Japan, India, China, Rest of World) Revenues (in millions) Hepatitis Vaccine Market (Table) World Pediatric Hepatitis Vaccine Market Haemophilus Influenzae Type B Vaccine Market (Table) World Hib Vaccine Market, Measles, Mumps and Rubella Vaccines (Table) World MMR Vaccines Market Combination Vaccines Market (Table) World Combination Vaccines Market Pneumococcal Vaccine (Table) World Pediatric Pneumococcal Vaccine Market Poliovirus Vaccine (Table) World Poliovirus Vaccine Market Varicella Vaccines (Table) World Varicella Vaccine Market Other Vaccines Market (Table) World Pediatric Other Vaccines Market Adult Preventive Vaccines INTRODUCTION ADULT VACCINE-PREVENTABLE DISEASES: FACTS AND FIGURES GLOBAL INFLUENZA SURVEILLANCE PROGRAM U.S. Surveillance RECOMMENDATIONS FOR ADULT IMMUNIZATIONS (Table) Universal Adult Immunization Schedule 2012 (Table) Summary of Recommendations for Adult Immunization ADULT VACCINE PRODUCTS Cervical Cancer (Table) Initiatives to Require HPV Vaccination by U.S. State, 2012 Cholera Diphtheria-Tetanus Hepatitis Influenza

3 (Table) WHO Pandemic Classification Schedule Japanese Encephalitis Pneumococcal Disease Rabies Shingles Typhoid Fever Yellow Fever ADULT VACCINES IN DEVELOPMENT (Table) Selected Adult Preventive Vaccines in Development, 2012 THEWORLD MARKET FOR ADULT PREVENTIVE VACCINES Total Market Size and Forecast (Table) World Market for Adult Preventive Vaccines by Type (Hepatitis, Influenza, Pneumococcal, Travel/DT/Misc.), Revenues (in millions) (Table) World Market for Adult Vaccines by Region (U.S., North America, South America, EU, Japan, India, China, Rest of World) Revenues (in millions) Cervical Cancer Market (Table) World Cervical CancerVaccine Market Hepatitis Market (Table) World Hepatitis Vaccine Market Influenza Vaccine Market (Table) World Influenza Vaccine Market (Table) 2011 Estimated Population by Region and Selected Age Group (in millions) (Table) World Pneumococcal Vaccine Market Travel, DT, and Miscellaneous Vaccine Market (Table) World Travel; Diphtheria-Tetanus; Miscellaneous Vaccines Market Vaccines Market Summary TRENDS DRIVING THE VACCINES MARKET MARKET SIZE AND FORECAST (Table) The World Vaccines Market by Vaccine Type Revenues (in millions) Vaccine Sales by Region Vaccine Market Competitors (Table) The World Vaccines Market by Region (U.S., North America, South America, EU, Japan, India, China, ROW) Revenues in millions (Table) Major Manufacturers' Shares of the World Vaccine Market, 2011 Pediatric Vaccines (Table) Major Manufacturer's Shares of the World Pediatric Vaccine Market 2011 Adult Vaccines (Table) Major Manufacturer's Shares of the World Adult Vaccine Market 2011 Issues and Trends VACCINE SAFETY Refusal to Immunize Obesity Post-Licensure Surveillance The Vaccine Injury Compensation Program

4 World Health Organization Other Initiatives The Future of Vaccine Safety VACCINE SHORTAGES Preventing Shortages in the Developed Countries Preventing Shortages in Developing Nations PREVENTING PANDEMICS U.S. National Vaccine Plan VACCINES AND BIOTERRORISM Overview Project Bioshield Act (Table) Selected Companies/Laboratories Developing Biodefense Vaccines National Bio and Agro-Defense Facility Vaccine Treatment and Evaluation Units Anthrax Smallpox DNA VACCINATION INNOVATIONS IN VACCINE DELIVERY SYSTEMS Mucosal Delivery Intranasal Delivery Vaccine Patches Vaccine Chips and Microneedles INNOVATIONS IN VACCINE PRODUCTION Plants Insects Nanoparticle Systems Cloning Company Profiles ALPHAVAX, INC. BAVARIAN NORDIC A/S BAXTER HEALTHCARE BHARAT BIOTECH

5 CRUCELL /JOHNSON &JOHNSON EMERGENT BIOSOLUTIONS Financial GLAXOSMITHKLINE MEDIMMUNE MERCK&CO. INC NOVARTIS SANOFI PASTEUR Company Directory

CHAPTER ONE: EXECUTIVE SUMMARY. The Global Vaccine Industry CHAPTER TWO: INTRODUCTION TO VACCINES

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