Maximizing your Profits in a Down Market Toby Hoffman Zoetis Territory Business Manager

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1 Maximizing your Profits in a Down Market Toby Hoffman Zoetis Territory Business Manager 1 Presentation Title 00/00/12 (Optional)

2 The Path To Cattle Health Minimize Exposure Health Effective Vaccine Quality vaccine with a proven and long DOI Handling, disinfectants, storage 2 Presentation Title 00/00/12 (Optional) Well Managed Calf Nutrition Preconditioning Management Handling

3 Prevention Immunological principles Vaccination Immunization PROTECTION

4 Basic immunology: Immunity HEALTH Challenge 4 Presentation Title 00/00/12 (Optional)

5 Basic immunology: Immunity HEALTH Challenge illness 5 Presentation Title 00/00/12 (Optional)

6 Basic immunology: Immunity illness HEALTH Challenge 6 Presentation Title 00/00/12 (Optional)

7 Basic immunology: New born calf has NO Antibody Immunity until it ingests colostrum. HEALTH / illness???? Challenge 7 Presentation Title 00/00/12 (Optional)

8 Basic immunology: Passive Immunity - colostrum Active Immunity - exposure HEALTH Challenge illness 8 Presentation Title 00/00/12 (Optional)

9 MLV vs. Killed Virus Vaccines MLV Fast Efficacy superior One dose Precautions Killed Safe Simple Efficacy less Slower immunity 9 Presentation Title 00/00/12 (Optional)

10 Cow Vaccine Programs MLV Better Fetal Protection Less Cost Killed Virus Lesser Fetal Protection Greater Cost Conditional Safety in Pregnant cows & nursing calves Require mixing Safety in Pregnant cows & nursing calves Do not require mixing 10 Presentation Title 00/00/12 (Optional)

11 SECTION DIVIDER

12 Cow Vaccines Modified Live Killed Hybrid

13 Vaccine composition Bovi-Shield GOLD FP 5 CattleMaster GOLD FP 5 Modified Live BVD type 1 Killed Modified Live BVD type 2 Killed Modified Live IBR Temperature Sensitive Modified Live PI3 Temperature Sensitive Modified Live BRSV Modified Live

14 Comparison of three commercial vaccines for preventing persistent infection with bovine viral diarrhea virus S Rodning, S Marley, Y Zhang, A Eason, C Nunley, P Walz, K Riddell, P Galik, B Brodersen, MD Givens 14 Rodning, et al, Therio, 2010

15 MLV Versus Killed Efficacy in Pregnant Heifers? Vaccinated 4x Weaning, 1 mo Yearling, 1 mo Control (not vaccinated) Viremic 10/10 Gave Birth to PI Calves 10/10 BSG Pyramid Virashield 0/20 1/20 10/20 0/20 0/20 2/18 (Rodning, 2010) 15

16 SECTION DIVIDER

17 Intranasal Vaccine Local Mucosal Immunity BRSV Protection Maternal Antibody Antigen Interference Rapid Protection Safety Life Cycle Management of Calf Health

18 Inforce 3 and One-Shot BVD Images property of Zoetis, Inc. 19

19 MLV KiMLllBRD Vaccine The risk of Bovine Respiratory Disease is over 2X greater when vaccinated with a killed vaccine (versus modified live) Beef Research Report, Iowa State The cost and predictive factors of Bovine Respiratory Disease in standardized steer tests Faber R, Hartwig N, Busby D, Bredahl R 20

20 ADMINISTRATION DETAILS True name: Bovine Rhinotracheitis-Virus Diarrhea- Parainfluenza 3 -Respiratory Syncytial Virus Vaccine, Modified Live Virus, Mannheimia Haemolytica Toxoid Convenient, one-dose administration 2 ml dose administered SC in the neck region Available in 5-, 10- and 50-dose sizes 21

21 22

22 Parasite Control 23

23 What Do We Know About Generic We don t know enough! Dewormers? We know that formulations have a major impact on pharmacokinetics (PK). We know that uv light, purity of excipients and porosity of packaging are very important in ML stability. We know that one study of generic IVM injectables showed significant variation in plasma levels, and one of generic IVM pour-on s showed significant variation in efficacy.

24 Johnson Feedlot Study,

25 Dectomax PO vs Durvet PO: Difference in mean weight (lbs) 25 p= Dectomax Durvet 5 0 Day 0 Day 30 Day 60 Day 90 Day 162

26 Stocker Deworming Studies Summary Dectomax vs Ivomec (8/8 trials) lb/hd/day 108 day average = lbs Dectomax vs Cydectin (2/2 trials) lb/hd/day Persistence Pays

27 Cattle Implant Technologies

28 Why Implant Cattle? Implants are Products that help cattle grow faster Average Daily Gain (ADG) Products that help cattle consume less feed per pound of live animal gain Feed Efficiency (FE)

29 Weight Gain, lbs. Suckling Phase Gain of SYNOVEX C Implanted Calves Controlled Studies Non-Implanted SYNOVEX C lb Weight Gain Zoetis Database: 42 Comparisons comprising 7,865 calves from 16 states and Canada. SYN09007.

30 When Implants are Used Suckling Calves SYNOVEX C - 20: :1 ROI pounds Gain Stocker Cattle 10-15% increase in ADG Feedlot Cattle 10-18% improvement in ADG 6-11% improvement in FE Cattle can be reimplanted multiple times depending on total days on feed

31 Why Implant Cattle? Why is increased growth rate and feed efficiency important? Reduces cost of production Feed costs are largest expense Feed/Forage utilization per pound of gain (efficiency response) Animals reach targeted end point weight faster (gain response) Environmentally friendly Reduces production costs improves profitability

32 Overall Animal Effect of Estrogens Estrogens Increased muscle protein deposition Increased feed intake

33 Effects of Steroid Implants on Cattle Growth ADG Gain Efficiency Utilization of absorbed nitrogen by decreased urinary nitrogen loss Increased mature body size Green technology

34 Implanted Beef Safety Estrogenic Levels of Several Common Foods 35,000ng low dose birth control pill 2,700ng 4 ounces of cabbage 993ng 1 egg 908ng bowl of split pea soup Nanogram (ng) is one billionth of a gram 567ng 1 ounce of wheat germ 34ng 8 ounces of milk Collins et al., 1989, Booth et al., 1960; Verdeal and Ryan, ng 3 ounces of beef (implanted steer) 1.2ng 3 ounces of beef (non-implanted steer)

35 Implanted Beef Safety Daily Human Estrogen Production (Nanograms) 600, , ,000ng Non-pregnant Women** 400, , ,000ng 200,000 54,000ng 41,500ng Normal Adult Male 100,000 Girls (before puberty) Boys (before puberty) 0 Pregnancy: 90 million ng/d Hoffman & Evers, 1986

36 Implant Safety ALL Implants have ZERO meat withdrawal times. Placed in inedible tissue. Have been approved by the FDA since the 1950 s as: Safe for humans Safe for cattle Effective

37 Suggested Calf Vaccination Program Spring (Branding/Turnout): Inforce 3 (IBR, PI3, BRSV) One Shot BVD (Mannheimia & BVD) Ultrabac or UltraChoice (clostridial) Dectomax injectable Synovex C Fall (Pre-weaning): Bovi-Shield GOLD One Shot Ultrabac or UltraChoice Dectomax injectable Always discuss your vaccination program with your herd veterinarian!

38 Questions? Toby Hoffman Zoetis Territory Business Manager 39 Presentation Title 00/00/12 (Optional)

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