Product Catalog. Dental Bone & Tissue Regeneration
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1 Product Catalog Dental Bone & Tissue Regeneration
2 Bone graft regeneration Guided bone substitutes regeneration Osteogenesis Controlled resorption rate Angiogenesis Long term volume stability Remodeling Optimal bone quality Natural osteoconduction Soft tissue regeneration Guided soft tissue regeneration Integration Excellent wound healing Vascularisation Easy handling Barrier function Optimal barrier function 2 Hydrophilic properties
3 botiss dental Safety, Reliability, Innovation and Maximum Choice in Dental Bone & Tissue Regeneration Dear Clinical User, botiss dental is a leading European specialist for biomaterial solutions in dental bone and tissue regeneration (BTR) for Implantology, Oral Surgery, CMF and Periodontology. We develop, produce and apply the most comprehensive portfolio of wellproven and innovative dental regenerative products, offering optimized solutions for a wide range of clinical indications out of one hand. As we all know no single material can suit all medical requirements and indications. You have - via botiss and as shown in this catalogue - access to the widest choice of products based on the leading technology platforms serving all your needs for bovine, allograft, alloplastic and collagen-based materials on the highest quality level. Patient safety and reliable and predictable treatment success is our first priority. Our products have proven their success in clinical studies, cases and even more in the daily use with thousands of patients worldwide. Our products are produced under cleanroom conditions, according to highest quality and safety standards. Research and Development partnerships with worldwide renowned academic research institutions and leading practitioners result into BTR products with highest safety, efficiancy, reliability and superior handling characteristics. botiss invests substantially into research on new biologic materials and procedures improving and accelerating bone formation and soft tissue regeneration. Our leading BTR product portfolio is marketed via a global network of national distribution partners in over 50 countries worldwide. All partners are dedicated specialists in dental surgery. We are proud that you have decided to work with our materials. We are eager to hear and discuss your experiences and to listen to your suggestions for improvements or new developements. Sincerely yours, Dr. Drazen Tadic dt@botiss.com Oliver Bielenstein ob@botiss.com 3
4 Bone graft regeneration cerabone Natural Bovine Bone maxresorb Synthetic Bi-Phasic Calcium Phosphate maxgraft Processed Human Allograft perossal Nano-Crystalline Hydroxyapatite Composite 4
5 cerabone Natural Bovine Bone Grafting Material cerabone is a highly reliable, dimensional stable, purified natural bovine bone grafting material. The mineral composition, the three dimensional structure and the physico-chemical and biological properties of cerabone are very similar to those of human bone. The unique manufacturing process with high-temperature heating removes all organic components and eliminates all potential immunological reactions: cerabone is 100% BSE-safe and 100% protein-free. cerabone fulfils all requirements of the Annex II.4 of the Directive 93/42/ EEC and the Directive 2003/32/EC. SEM: Human bone Properties - natural bovine bone grafting material - slow resorption and directed integration by new bone formation - long-term dimensional stability - osteoconductive - 100% pure bone mineral - no foreign body or inflammatory reaction - hydrophilic surface, optimal cell adhesion and blood absorption - interconnective porosity - safe and sterile - easy handling SEM: cerabone Indications: Implantology, Periodontology & Oral Surgery - Sinus lift - Horizontal augmentation - Intraosseous defects - Peri-implant defects - Extraction sockets - Vertical augmentation - Furcation defects Product Specifications cerabone Granules Article No. Particle Size Content x0.5cc (ml) x1.0cc (ml) x2.0cc (ml) x5.0cc (ml) Article No. Particle Size Content mm 1x0.5cc (ml) mm 1x1.0cc (ml) mm 1x2.0cc (ml) mm 1x5.0cc (ml) cerabone Block Article No. Dimension Content x20x10mm 1xBlock Histology of cerabone 6 months after Sinus lift. Optimal integration and bone healing with cerabone cerabone packaging cerabone product family 5
6 maxresorb Innovative Bi-Phasic Calcium Phosphate SEM: maxresorb Granules maxresorb is an innovative, safe, reliable and fully synthetic bone graft substitute with improved controlled resorption properties and outstanding handling characteristics. The homogenous composition of 60% hydroxyapatite (HA) and 40% beta-tri-calcium phosphate (β-tcp) results in two mineral phases of activity: it supports the formation of new vital bone and maintains the volume and mechanical stabillity. The high osteoconductivity of maxresorb is achieved by a matrix of interconnecting pores and a very high porosity of ~ 80%, as well as pore sizes of 200 to 800µm. The high macroporosity of maxresorb is ideal for intense osteogenic cells growth and optimally promotes the regeneration of vital bone. The high microporosity of maxresorb facilitates the increased diffusion of biological fluids. maxresorb is not a mix but a synthesis of both phases. SEM: Interconnective Window Properties - Synthetic, resorbable - Volume & mechanical stability - Safe, reliable and sterile product - Macropores µm - 60% HA / 40% beta TCP - Osteoconductive - Ultra high interconnected porosity - Micropores 1-10µm Indications: Implantology, Periodontology, Oral Surgery & CMF - Sinus lift - Ridge augmentation - Intraosseous defects - Extraction sockets - Osseous defects - Furcation defects Product Specifications Histology of maxresorb 6 months after Sinus lift. Optimal integration and bone healing with maxresorb maxresorb Granules Article No. Particle Size Content (S) 1x0.5cc (ml) (S) 1x1.0cc (ml) Article No. Particle Size maxresorb Cylinder Article No. Dimension Content Ø 7.5mm; Height 15mm 1xCylinder Content mm (L) 1x0.5cc (ml) mm (L) 1x2.0cc (ml) 6 maxresorb product family maxresorb packaging
7 maxgraft Processed Human Allograft maxgraft is a high quality product of human origin. With maxgraft the user benefits of a safe and sterile allograft, which supports and increases the bone healing process purposefully. maxgraft is processed in compliance with the highest quality standards under clean room conditions. According to the current pharmaceutical laws the manufacturer is obliged to obtain a production permit from the authority in charge. The partners involved in the production as a holistic process are connected to each other by the tissue bank in terms of quality and distinguished from each other in terms of pharmaceutical aspects in order to realise clear interfaces ensuring the highest level of transparency and trackability at all times. SEM: maxgraft Granules Properties - Preserved biomechanical properties - Sterile without antigene effects - Storeable at room temperature - Osteoconductive properties supporting natural and controlled remodelling Indications: Implantology, Periodontology, Oral Surgery & CMF Granules - Localized augmentation of the ridge for future implant placement - Reconstruction of the ridge for prosthetic therapy - Filling of osseous defects, such as extraction sockets - Elevation of maxillary sinus floor - Augmentation or reconstructive treatment of alveolar ridge - Repair of intrabony periodontal defects Blocks - Provides a predictable and highly effective alternative to traditional block grafting - Increases bone volume for surgical ridge augmentation in patients where bone volume has been reduced due to atrophy Product Specifications maxgraft Granules Article No. Particle Size Content x0.5cc (ml) x2.0cc (ml) SEM: maxgraft mineralised collagen fibres Histology of maxgraft 5 months after implantation. Optimal integration and bone remodeling with maxgraft maxgraft Block (cortico-spongiosa) maxgraft Blocks Article No. Dimension Content cortico-spongiosa 10x10x20mm 1xBlock spongiosa 10x10x20mm 1xBlock maxgraft Block (spongiosa) maxgraft Granules packaging 7
8 perossal Unique, Nanocrystalline Calcium Phosphate Matrix SEM: perossal cone surface perossal is a unique, synthetic, osteoconductive and resorbable bone graft substitute. perossal is a composite of nanocrystalline hydroxyapatite and calcium sulphate. The nanocrystalline hydroxyapatite gives perossal a very high specific surface which allows proteins and growth factors to bond directly on the surface and results in controlled osteostimulation of the surrounding tissue. The nano- and micro-porous network of perossal offers the possibilty to load the bone graft substitute individually with liquids (e.g. antibiotics) and provides the property of a controlled prolonged release. perossal permits guided bone regeneration together with the stabilisation of the alveol or extracted socket. SEM: perossal nano & micro porosity Properties - Synthetic, 100% resorbable - Volume & mechanical stability - Safe, reliable and sterile product - nano & micro pores - nano HA / Calcium sulfate composite - Osteostimulative - Individual liquid/antibiotic loading - Controlled prolonged release i.e. of liqud antiobiotics perossal controlled release and bone regeneration Time Bone Regeneration Controlled Prolonged Release perossal Indications: Implantology, Oral Surgery & CMF - Osseous defects - Extraction sockets - In combination with antibiotics in infected/contaminated bone areas Product Specifications perossal Synthetic Alveo Cones Article No. Dimension Content Volume Ø 6mm; 6mm height 1x6 pieces/cones 1.2cc (ml) Ø 6mm; 6mm height 2x6 pieces/cones 2.4cc (ml) Histology of perossal biopsy taken 4 months after surgery. Optimal integration and bone healing with perossal 8 perossal alveo cones perossal packaging
9 Soft tissue regeneration Jason collagen membrane Native Pericardium Membrane Jason collagen fleece Native Collagen Fleece collacone Native Collagen Alveo Cone 9
10 Jason membrane Highly Effective, Resorbable Natural Soft Tissue Jason membrane provides a long-lasting, adequate barrier function. Due to a unique production process, the superior properties of the native pericardium are preserved, maintaining the characteristics of this natural tissue. Properties SEM: Jason membrane SEM: Jason membrane 3 dimensional-structure - Long-lasting barrier function: wound protection and stabilisation of blood clot in the defect space - Biocompatible: no removal necessary, remodeled into connective tissue through body-own tissue healing processes - Cell-occlusive: promotes osteoblast and periodontal ligament cell proliferation while excluding gingival cell invasion - Stability: multidirectional strength and tear resistance, accepts a wide range of sutures and fixation devices - Drapeability: supple but strong, with exceptional adaptability to surface contours - Rapid rehydration and easy manipulation - ease of placement and conformity to graft site - Three convenient sizes can be cut to shape for specific procedures Indications: Implantology, Periodontology, Oral Surgery & CMF Histology of Jason membrane 4 weeks after implantation shows perfect integration without inflammatory reaction - Simultaneous use of GBR-membrane (Jason membrane), bone substitutes and implants - Augmentation around implants placed immediately or delayed extraction sockets - Localized ridge augmentation for later implantation - Alveolar ridge reconstruction for prosthetic treatment - Filling of bone defects after root resection, cystectomy, removal of retained teeth - Guided bone regeneration in dehiscence defects - Socket preservation - Protection of the Schneiderian membrane - Covering of minor perforations of the Schneiderian membrane Product Specifications Jason membrane Article No. Size Content x20mm 1 piece x30mm 1 piece x40mm 1 piece 10 Jason membrane Jason membrane packaging
11 Jason collagen fleece Highly Effective, Resorbable Natural Soft Tissue Jason collagen fleece is a ph-neutral, wet-stable haemostyptic made of native collagen. The potent haemostatic effect of collagen is well known and induced by the adhesion of platelets to the collagen fibrils. As a consequence, platelets aggregate and release coagulation factors by degranulation. This initiates the coagulation cascade resulting in haemostatis. Properties - ph-neutral and very efficient local haemostasis - Strong adhesive properties in liquid environment - Absorbable and fast degradation by enzymatic reaction - Can be easily applied and removed if necessary - Maintains integrity in the presence of blood and during application SEM: Jason collagen fleece Indications: Implantology, Periodontology, Oral Surgery & CMF - Minor oral wounds - Closure of grafted sites - Repair of Schneiderian Membrane - Extraction sites - Mucosal flaps - Biopsy sites SEM: Jason collagen fleece 3 dimensional structure Product Specifications Jason collagen fleece Article No. Size Content pieces (single units) x50mm 10 pieces (single units) Clinical use of Jason collagen fleece Jason collagen fleece packaging Jason collagen fleece 11
12 collacone Highly Effective, Resorbable Natural Soft Tissue collacone is a wet-stable haemostyptic cone made of native collagen. collacone is a soft, white, pliable, resorbable collagen wound dressing for daily use in the field of dental surgery. Due to the spongy conus structure, application of collacone to the wound is easily controlled. collacone retains the structural integrity after placement into the defect site. SEM: collacone Properties - Resorption within 2-4 weeks - Stabilisation of blood clot and efficient local haemostasis - Maintains integrity in the presence of blood and during application - Wound protection SEM: collacone collagen fibres 3 dimensional network - 3 dimensional matrix for tissue ingrowth - Controlled wound healing process - 100% native collagen cone Indications: Implantology, Periodontology & CMF - Extraction sites - Biopsy sites - Minor oral wounds Product Specifications Clinical use of collacone collacone Native Collagen Alveo Cone Article No. Shape Content pieces (single units) 12 collacone collacone packaging
13 Clinical cases Implantology, Peridontology, Oral Surgery & CMF Sinus Lift Clinical view of the Sinus lift area. Extraction Socket Opening of the lateral Sinus lift window. Filling of the Sinus cavity with Cerabone 1-2mm particle size. Covering the lateral Sinus lift area with Jason membrane 20x30mm size. After tooth extraction, a large-volume socket is visible. Cerabone particle size is inserted. Covering with a soft tissue punch and sutured. Clinical situation after 4 weeks healing time. Horizontal & Vertical Augmentation Clinical situation after implant placement. Augmentation in horizontal and vertical direction with Cerabone 1-2mm particle size Covering of the augmentation area with shaped Jason membrane 20x30mm size. Wound closure with suturing. Intraosseous Defect Clinical situation bone defect in vertical direction. Bone defect filled with Cerabone particle size and autologous bone. Covering the area with Jason membrane 15x20mm size. Wound closure with suturing. 13
14 Product Portfolio Indication table Products Indication cerabone Granules maxresorb Granules maxgraft Granules Jason Fleece Jason Membrane PerOssal Cones Extraction socket 0.5; 1.0cc 0.5; 1.0cc 0.5cc * 15x20mm 1x6; 2x6 Sinus floor elevation mm 2; 3; 5cc mm 2cc 2cc 2nd choice* * 15x20mm 20x30mm Horizontal augmentation mm 2; 3; 5cc mm 2cc 2nd choice 2cc 2nd choice* * 20x30mm 30x40mm Ridge preservation mm 2; 3; 5cc mm 2cc 2cc 2nd choice* * 30x40mm Fenestration defect 0.5; 1.0cc 0.5; 1.0cc 0.5cc 2nd choice* * 20x30mm Implant dehiscence 0.5; 1.0cc 0.5; 1.0cc 0.5cc 2nd choice* * 20x30mm Intraosseous defects (1-3 walls) 0.5cc 0.5; 1.0cc 2nd choice 0.5cc * * 15x20mm Furcation defects (class I II) 0.5cc 0.5cc 2nd choice 0.5cc * * 15x20mm Vertical augmentation mm 2; 3; 5cc mm 2cc 2nd choice 2cc Protection Schneiderian membrane Note: In large defects a mixture of granules with autogenous bone is always recommended (mixture rate 50/50)! 15x20mm 20x30mm * in combination with granules/coverage Granules Membrane 14 Cones Fleece
15 Product Specifications cerabone cerabone Granules Article No. Particle Size Content Article No. Particle Size Content x0.5cc (ml) mm 1x0.5cc (ml) x1.0cc (ml) mm 1x1.0cc (ml) x2.0cc (ml) mm 1x2.0cc (ml) x5.0cc (ml) mm 1x5.0cc (ml) cerabone Block Article No. Dimension Content x20x10mm 1xBlock maxgraft maxgraft Granules Article No. Particle Size Content x0.5cc (ml) x2.0cc (ml) maxgraft Blocks Article No. Dimension Content x10x20mm 1xBlock cortico-spongiosa x10x20mm 1xBlock spongiosa maxresorb maxresorb Granules Article No. Particle Size Content Article No. Particle Size Content (S) 1x0.5cc (ml) mm (L) 1x0.5cc (ml) (S) 1x1.0cc (ml) mm (L) 1x2.0cc (ml) maxresorb Cylinder Article No. Dimension Content Ø 7.5mm; Height 15mm 1xCylinder Jason membrane Article No. Size Content x20mm 1 piece x30mm 1 piece x40mm 1 piece Jason collagen fleece Article No. Size Content pieces (single units) x50mm 10 pieces (single units) collacone Native Collagen Alveo Cone Article No. Shape Content pieces (single units) perossal Synthetic Alveo Cones Article No. Dimension Content Ø 6mm; 6mm height 1x6 pieces/cones 1.2cc/ml Ø 6mm; 6mm height 2x6 pieces/cones 2.4cc/ml 15
16 botiss dental GmbH Glinkastrasse Berlin / Germany Fon Fax contact@botiss.com
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