HOSPITAL INNOVATIONS
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1 idente Catalogue
2 About HOSPITAL INNOVATIONS Since 2008, Hospital Innovations has been supplying a growing range of specialist products for use in orthopaedic and corrective surgery; with an emphasis on innovation and quality. Strong commitment to healthcare innovation Hospital Innovations is a Human Tissue Authority (HTA) licensed establishment, allowing us to store and distribute human allograft tissue and bone with the support of our valued international partners; two of the world s leading tissue banks. Hospital Innovations is comprised of six distinct divisions; each with a unique focus, but all operating under Hospital Innovations aim of delivering innovative, safe and effective solutions. Dedicated to providing safe and effective treatment options for your patient Across all divisions, Hospital Innovations endeavour to responsibly deliver outstanding customer support within our service levels and product range. Our detailed, consultative approach to service support and training is the cornerstone of Hospital Innovations philosophy. Consistent delivery of outstanding customer service Safety, effectiveness and consistency of quality are Hospital Innovations core values; with a mindful and sensitive appreciation that the end-user is a person in need. 1
3 DRIVING THE FUTURE 2
4 INTRODUCING idente 3
5 About idente With innovation at the foundation of its success, Hospital Innovations now provide a range of dental products to assist surgical procedures. Hospital Innovations idente catalogue includes an extensive array of both allograft and synthetic bone substitution products, demineralised bone matrices and HA enriched viscosupplementation injections. The idente division is committed to providing both innovative and cost effective dental solutions to its customers. Applications Hospital Innovations dental portfolio is designed to assist surgeons with a multitude of dental procedures such as sinus lifts, ridge augmentations and the repair of periodontal defects. Products are available in a range of sizes to accommodate various applications and are packaged with a long shelf life. Freeze-dried Crushed Cancellous Chips Cancellous Cubes Mineralised Cancellous Particulate Freeze-dried Corticocancellous Chips Demineralised Cortical Particulate with PAD Mineralised Cortical Particulate Mineralised Corticocancellous Particulate Mix Optium DBM NanoBone HYALOSS Matrix OrACELL ORTHOVISC mini Periodontal Defects Ridge Augmentation Extraction Site Preservation Sinus Grafting Void/Socket Filling TMJ Pain Relief Figure 1. Comparison of Appropriate Uses for idente Products 4
6 Human Allograft OraGRAFT. Freeze-dried Cubes and Particulate. Hospital Innovations is the largest independent private Human Tissue Bank in the UK, fully licensed and regulated by the Human Tissue Authority. Available as both mineralised and demineralised, our cortical and cancellous allografts provide an osteoconductive scaffold for bone ingrowth and rapid remodelling with the patient s own bone. Products are available in a range of sizes in either cube or particulate formulation to accommodate an array of dental procedures. Sterility Each of Hospital Innovations human allograft products provide a guaranteed Sterility Assurance Level (SAL) of 10-6, the same as that for medical devices. This means that no more than a single viable particle in 1 million units could potentially be compromised, providing exceptional product reliability [1]. This level of sterility is achieved via a patented cleaning and disinfection process called Allowash XG. This process removes more than 99% of bone marrow and blood elements from the bone matrix, rendering it sterile [1]. Allowash XG follows a six stage process to ensure bioimplant safety without compromising the biomechanical or biochemical properties of the tissue [2]. Figure 2. Before Allowash XG Sterilisation [2] Figure 3. After Allowash XG Sterilisation [2] 5
7 Demineralised Bone Matrix Optium DBM. Setting the Standard for DBM Performance. Optium DBM has both osteoconductive and osteoinductive properties that provide a natural architecture with increased surface area to encourage cellular attachment [3]. A ready to use product with consistent handling properties, Optium DBM is available in putty or gel formations and has proven clinical results for any bone filling application [3]. Demineralisation Process Demineralisation is achieved when the residual calcium level is below 8%. However, the PAD demineralisation process is able to consistently target a 1-4% residual calcium range, which studies have shown provides the most osteoconductive potential [4]. The PAD process also eliminates both over and under demineralisation, which can have a detrimental effect on osteoconductive potential and performance. To place an order, please contact us: Phone: Fax: orders@hospitalinnovations.co.uk 6
8 Synthetic Grafting NanoBone. The Synthetic Bone Grafting Alternative. NanoBone is a synthetic bone grafting material that is ready to use with no preparation time and available in granulate, block and putty variations. Its nanocrystalline hydroxyapatite nanostructure enhances angiogenesis, thus allowing for rapid bone formation in as little as 3 months [5]. This structure improves porosity, providing an increased surface area when compared to a bovine equivalent. As blood populates the porous nanostructure, NanoBone is recognised as a material familiar to the body, preventing an immunological response. It also permits for complete remodelling and resorption due to its osteoclastic characteristics. This allows NanoBone to be completely remodelled and replaced with bone [6]. Recommendations for Use Granulate Sinus Lifts Socket Preservation Lateral Augmentation Intraosseous Defects Furcations Cystectomy / Root End Surgery Block Lateral Augmentation Intraosseous Defects Putty Bone Void / Gap Filler Intraosseous Defects 7
9 Hyaluronic Acid Carrier HYALOSS Matrix. Bioactive Hyaluronic Acid Matrix. HYALOSS Matrix provides a gradual release of pure hyaluronic acid (HA) which promotes the activation and stimulation of fibroblasts and endothelial cells. This helps to boost the physiological regeneration of natural, highly vascularised tissue [7]. When hydrated, it forms a gel like substance which improves both the handling and retention of a bone graft at the defected site without compromising the osseous regeneration potential of the graft [7]. Intended as an adjunct of the grafting process, HYALOSS Matrix can be used as part of any regenerative therapy. How to Use Mix fibres with sterile saline solution or patients own blood to form a gel Mix the gel with bone particulate such as our OraGRAFT allograft (pg. 5) or NanoBone synthetic (pg. 7) to create a paste Apply to the defected area The HYALOSS Matrix Advantage Promotes bone graft application Easy handling Conforms to any defect type Biocompatible and naturally absorbed Natural, non-animal sourced 8
10 Decellularised Dermis OrACELL. A High Performance Acellular Dermal Matrix. Case Study OrACELL is a superior allograft dermis which is ready to use off the shelf, requiring no surgical preparation time. Its efficient handling properties, pull out strength and load to failure make OrACELL ideal for dental applications. Through the use of MATRACELL technology, more than 97% of DNA from the dermal matrix is removed [8]. This renders the dermis acellular without compromising the biological or biomechanical properties of the tissue. Hospital Innovations acellular dermal matrix is intended for use in conjunction with bone regeneration and oral soft tissue correction procedures. A surgery performed for implant placement at the sites of congenitally missing lateral incisors. A combination of OraGraft mineralised cortical particulate and OrACELL decellularised dermis were placed on the labial to correct the thin bone support and to increase the soft tissue profile in these areas. Four weeks after implantation Figure 4. Case Study of Missing Lateral Incisor Implant Surgery Using OrAGRAFT and OrACELL [8] 9
11 Viscosupplementation Hospital Innovations also offer a HA enriched viscosupplementation injection, aimed at targeting small joints such as the TMJ. With the highest HA concentration available on the market, ORTHOVISC mini is a safe and reliable alleviator of persistent joint pain. Product Features Specially designed for small joints Created from ultra-pure, natural hyaluronan Provides pain relief from symptoms of osteoarthritis High molecular weight Highest HA concentration of any small injection Improving TMJ Function Figure 6. Improvement in Mean Total Anamnestic Score between Proven to provide long lasting TMJ pain relief after one injection Figure 5. Comparison of Viscosity and Molecular Weight of Hyaluronan Properties [9] A single injection provided at least 6 months of consistent benefit Proven safe injection procedure Reduction in painful symptoms including; 22% improvement in mouth function 28% decrease in lower jaw pain 24% decrease in TMJ palpation pain [11] Hyaluronic Acid and a Placebo [10] 10
12 Ordering Information CANCELLOUS Freeze-dried Chips Product No. Product Description CH20002 Freeze-dried, Crushed Cancellous Chips: 1-4mm, 15cc CH20004 CH20006 CH20008 CH20021 CH20023 CH20024 CH20025 CH20026 CH20027 CH20029 CH20041 CH20042 CH20043 CH20044 CH20045 Freeze-dried, Crushed Cancellous Chips: 1-4mm, 30cc Freeze-dried, Crushed Cancellous Chips: 1-4mm, 60cc Freeze-dried, Crushed Cancellous Chips: 1-4mm, 90cc Freeze-dried, Crushed Cancellous Chips: 1-8mm, 5cc Freeze-dried, Crushed Cancellous Chips: 1-8mm, 15cc Freeze-dried, Crushed Cancellous Chips: 1-8mm, 20cc Freeze-dried, Crushed Cancellous Chips: 1-8mm, 30cc Freeze-dried, Crushed Cancellous Chips: 1-8mm, 40cc Freeze-dried, Crushed Cancellous Chips: 1-8mm, 60cc Freeze-dried, Crushed Cancellous Chips: 1-8mm, 90cc Freeze-dried, Crushed Cancellous Chips: 4-10mm, 5cc Freeze-dried, Crushed Cancellous Chips: 4-10mm, 15cc Freeze-dried, Crushed Cancellous Chips: 4-10mm, 30cc Freeze-dried, Crushed Cancellous Chips: 4-10mm, 60cc Freeze-dried, Crushed Cancellous Chips: 4-10mm, 90cc Freeze-dried Cubes and Blocks Product No. Product Description AD10001 Freeze-dried Cancellous Cubes: 15x15x15mm AD10002 AD10003 AD10004 CH20100 CH20101 Freeze-dried Cancellous Cubes: 15x15x8mm Freeze-dried Cancellous Cubes: 15x30x8mm Freeze-dried Cancellous Cubes: 10x10x10mm Freeze-dried Cancellous Cubes: 5cc (5x5x5mm) Freeze-dried Cancellous Cubes: 15cc (5x5x5mm) 11
13 Product No. Product Description CH20102 Freeze-dried Cancellous Cubes: 20cc (8 Cubes: 10x10x10mm) CH20103 CH20104 CH50130 Freeze-dried Cancellous Cubes: 30cc (12 Cubes: 10x10x10mm) Freeze-dried Cancellous Cubes: 40cc (16 Cubes: 10x10x10mm) Freeze-dried Cancellous Blocks: 20x20x30mm Mineralised Particulate Product No. Product Description AD10050 Mineralised Cancellous Particulate: microns, 0.5cc AD10051 AD10052 AD10053 AD10054 AD10055 Mineralised Cancellous Particulate: microns, 1cc Mineralised Cancellous Particulate: microns, 2cc Mineralised Cancellous Particulate: microns, 0.5cc Mineralised Cancellous Particulate: microns, 1cc Mineralised Cancellous Particulate: microns, 2cc CORTICAL Freeze-dried Demineralised Particulate Product No. Product Description AD10040 Demineralised Cortical Particulate with PAD : microns, 0.25cc AD10041 AD10042 AD10043 AD10044 Demineralised Cortical Particulate with PAD : microns, 0.5cc Demineralised Cortical Particulate with PAD : microns, 0.7cc Demineralised Cortical Particulate with PAD : microns, 1.2cc Demineralised Cortical Particulate with PAD : microns, 2.5cc Freeze-dried Mineralised Particulate Product No. Product Description AD10045 Mineralised Cortical Particulate: microns, 0.25cc AD10046 AD10047 AD10048 AD10049 Mineralised Cortical Particulate: microns, 0.5cc Mineralised Cortical Particulate: microns, 0.7cc Mineralised Cortical Particulate: microns, 1.2cc Mineralised Cortical Particulate: microns, 2.5cc 12
14 CORTICOCANCELLOUS Freeze-dried Chips Product No. Product Description CH50042 Freeze-dried, Corticocancellous Chips: 1-8mm, 10cc CH50043 CH50044 CH50045 CH50046 CH50047 CH50048 Freeze-dried, Corticocancellous Chips: 1-8mm, 20cc Freeze-dried, Corticocancellous Chips: 1-8mm, 30cc Freeze-dried, Corticocancellous Chips: 1-8mm, 40cc Freeze-dried, Corticocancellous Chips: 1-8mm, 60cc Freeze-dried, Corticocancellous Chips: 1-8mm, 90cc Freeze-dried, Corticocancellous Chips: 1-4mm, 90cc Mineralised Particulate Product No. AD10056 AD10057 AD10058 Product Description Mineralised Corticocancellous Particulate Mix: microns, 0.50cc Mineralised Corticocancellous Particulate Mix: microns, 1.0cc Mineralised Corticocancellous Particulate Mix: microns, 2.0cc NANOBONE Product No. NB50001 NB50002 NB50003 NB50004 NB50005 NB50006 NB50007 NB50008 NB50009 NB50010 NB50011 NB50012 NB50013 NB50014 NB50015 Product Description NanoBone Putty: 0.5ml NanoBone Putty: 1ml NanoBone Putty: 2.5ml NanoBone Putty: 5ml NanoBone Putty: 10ml NanoBone Granules: 0.6x2mm, 0.6ml NanoBone Granules: 0.6x2mm, 5x0.6ml NanoBone Granules: 0.6x2mm, 1.2ml NanoBone Granules: 0.6x2mm, 5x1.2ml NanoBone Granules: 0.6x2mm, 2.4ml NanoBone Granules: 0.6x2mm, 5x2.4ml NanoBone Granules: 0.6x2mm, 5ml NanoBone Granules: 1x2mm, 1.2ml NanoBone Granules: 1x2mm, 5x1.2ml NanoBone Granules: 1x2mm, 2.4ml 13
15 Product No. Product Description NB50016 NanoBone Granules: 1x2mm, 5x2.4ml NB50017 NB50018 NanoBone Granules: 1x2mm, 5ml NanoBone Granules Block: 5x10x15mm OPTIUM DBM Product No. DE50090 DE50091 DE50092 DE50093 DE50094 DE50095 DE50096 Product Description DBM Optium Gel: 1cc DBM Optium Gel: 5cc DBM Optium Gel: 10cc DBM Optium Putty: 1cc DBM Optium Putty: 2.5cc DBM Optium Putty: 5cc DBM Optium Putty: 10cc ORACELL Product No. AD10100 AD10101 AD10102 AD10103 AD10104 AD10105 AD10106 AD10107 Product Description OrACELL Decellularised Dermis with MATRACELL : 15x20mm, mm thick OrACELL Decellularised Dermis with MATRACELL : 20x40mm, mm thick OrACELL Decellularised Dermis with MATRACELL : 10x10mm, mm thick OrACELL Decellularised Dermis with MATRACELL : 10x40mm, mm thick OrACELL Decellularised Dermis with MATRACELL : 15x20mm, mm thick OrACELL Decellularised Dermis with MATRACELL : 20x40mm, mm thick OrACELL Decellularised Dermis with MATRACELL : 10x10mm, mm thick OrACELL Decellularised Dermis with MATRACELL : 10x40mm, mm thick HYALOSS MATRIX Product No. IN40060 Product Description HYALOSS Matrix: Box of 4 Sterile Blister Packs ORTHOVISC MINI Product No. IN40002 Product Description Orthovisc Mini 14
16 Enquiries For further information regarding any of our products, please feel free to contact our Customer Service Team. Customer Service Team Tel: Ordering To place an order, please contact us by phone, fax or Tel: Fax: Hospital Innovations Ltd Concept House Talbot Green Business Park Pontyclun CF72 9FG References 1. LifeNet Health. (2013). CMF & Dental Allograft Solutions: Saving Lives, Restoring Health. 2. LifeNet Health. (2009). Allowash XG : Allograft Bio-Implant Sterilisation Technology. 3. LifeNet Health. (2013). Optium DBM Putty. 4. LifeNet Health. (2013). Bio-Implant Reference Manual. 5. Meier, J., Heine, M. and Wolf, E. (2007). Shortening Therapy Protocols by using the Nanocrystalline Bone Substitute NanoBone for Sinus Floor Elevations and Augmentation of other Bone Defects. European Association for Osseointegration (EAO): Barcelona. 6. Artoss. Bone Formation in a New Dimension: Information on the Synthetic Bone Grafting Material NanoBone. 7. Anika Therapeutics. (2015). Hyaloss Matrix: Bioactive Hyaluronic Matrix for Bone Particulate Grafts in Regenerative Therapy. 8. LifeNet Health. (2013). OrACELL : Decellularised Dermis for Maxillofacial Applications. 9. Anika Therapeutics. Orthovisc mini: A Targeted Treatment for Small Joint Pain. 10. Bertolami, C., Gay, T., Clark, G., Rendell, J., Shetty, V., Changrui, L. and Swann, D. (1993). Use of Sodium Hyaluronate in Treating Temporomandibular Joint Disorders: A Randomised, Double Blind, Placebo Controlled Clinical Trial. Journal of Oral and Maxillofacial Surgery. 51, Orkun, F., Aytac, F. and Evcik, D. (2000). Clinical Use of Sodium Hyaluronate in treating Temporomandibular Joint Dysfunction. Medical Physics. 3(1). 15
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