Problem diagnoses. Current issues in Anatomic pathology. Problem Diagnoses in Tumors of the Oral Cavity 5/29/2009

Size: px
Start display at page:

Download "Problem diagnoses. Current issues in Anatomic pathology. Problem Diagnoses in Tumors of the Oral Cavity 5/29/2009"

Transcription

1 Current issues in Anatomic pathology Problem Diagnoses in Tumors of the Oral Cavity Richard Jordan DDS PhD FRCPath Professor of Oral Pathology & Pathology Director, UCSF Oral Pathology Diagnostic Laboratory University of California San Francisco Problem diagnoses 12 month period: 225 outside consults 70 cases originated by clinician at UCSF 155 cases requesting second opinion 18 cases from academic centers, 137 community hospitals Outside Dx UCSF Dx Outside Dx UCSF Dx Ameloblastic fibroma Desmoplastic fibroma Ameloblastic fibroma Desmoplastic fibroma Chronically inflamed fibrous tissue Chronically inflamed fibrous tissue Angioleiomyomatous neoplasm Low-grade myofibroblastic sarcoma Angioleiomyomatous neoplasm Low-grade myofibroblastic sarcoma BCC - cystic BCC - cystic Benign papillary ductal neoplasm Mucoepidermoid carcinoma, low grade Benign papillary ductal neoplasm Mucoepidermoid carcinoma, low grade Carcinoma in situ Mucin-rich salivary duct carcinoma Carcinoma in situ Mucin-rich salivary duct carcinoma Cementifying fibroma Chronic sclerosing osteitis Cementifying fibroma Chronic sclerosing osteitis Cystic Calcifying Odontogenic Cyst Cystic Calcifying Odontogenic Cyst Glandular odontogenic cyst Dentigerous cyst Glandular odontogenic cyst Dentigerous cyst Necrotic tissue Peripheral T-cell lymphoma Necrotic tissue Peripheral T-cell lymphoma Non-healing ulcer Epithelial dysplasia Non-healing ulcer Epithelial dysplasia Odontogenic Myxoma Dentigerous Cyst Odontogenic Myxoma Dentigerous Cyst Paget's Disease Sclerotic Bone Paget's Disease Sclerotic Bone Pindborg tumor Adenomatoid odontogenic tumor Pindborg tumor Adenomatoid odontogenic tumor Pleomorphic adenoma Mucoepidermoid carcinoma Pleomorphic adenoma Mucoepidermoid carcinoma Schwannoma MPNST Schwannoma MPNST Sialadenoma papilliferum Papillary cystadenocarcinoma Sialadenoma papilliferum Papillary cystadenocarcinoma Subacute inflammation Langerhans cell disease Subacute inflammation Langerhans cell disease 1

2 Outside UCSF Dysplasia/SCC Cyst Combination** 21 0 Odontogenic tumor Mucocutaneous disease BFOL Soft tissue tumor Topics 1. Epithelial dysplasia, grading 2. SCC & HPV 3. Odontogenic cysts & tumors Salivary gland disease/tumor 9 10 Bone 8 10 No diagnosis given 7 0 Lymphoproliferative disorder 2 3 Skin 1 0 **Combination = Dysplasia vs. mucocut = 9; Cyst vs odont tumor = 6; Other = 16 Epithelial Dysplasia 2

3 Idiopathic Leukoplakia Histology Hyperkeratosis 80% Dysplasia 12% In situ carcinoma 3% SCC 5% Leukoplakia Site Dysplastic or SCC (%) FOM 43 Tongue, ventral or lateral 24 Lip, lower 24 Palate 19 Buccal mucosa 17 Max/mand mucosa/sulcus 15 Retromolar area 12 Increasing severity (Hyperchromatism & crowding) Clinical Normal keratinocytes Histologic Molecular Hyperplasia Mild Dysplasia Severe Cancer 9p 3p, 17p 4q, 11q, 13q, 14,q, 17q, 6p, 8p 8q, 13p, 18q Slide from: Lippman NEJM Atypical keratinocytes Mild dysplasia Moderate dysplasia Progression of dysplasia Severe dysplasia 3

4 Microscopic features of dysplasia Normal Mild dysplasia Morphological features Cytological features Drop shaped rete pegs Basal cell hyperplasia Irregular stratification Reduced intercellular adhesion Pleomorphism Altered nuclear cytoplasmic ratios Increased and abnormal mitoses Enlarged nucleoli Moderate dysplasia Severe dysplasia Oral epithelial dysplasia Most oral SCC preceded by dysplasia Most important risk factor for oral cancer Overall risk: 16-32% Overall progression to SCC: Mild: 5% Moderate: 33% Severe: 50% Some sites higher risk: i.e. FOM Single lesion poor prediction Problems in the diagnosis & management of epithelial dysplasia Variations in the natural history Diagnosis and grading is subjective Excision is frequently followed by recurrence UC SF 4

5 Science January 30, 2009 Gillison et al. Human papillomavirus (HPV) and survival of patients with oropharynx cancer. NEJM (submitted) Gillison et al. Human papillomavirus (HPV) and survival of patients with oropharynx cancer. NEJM (submitted) 5

6 HNSCC Oropharyngeal SCC Location Any Oropharynx Tobacco history Yes No Alcohol history Yes No Marijuana association No Yes HPV No HPV 16 Morphology Keratinized Basaloid Odontogenic Cysts & Tumors p16 + No Yes p53 mutations Yes No Pre-existing dysplasia Yes No 5 year survival ~ 30-40% ~70-80% Stage predicts outcome Yes No Odontogenic Cysts & Tumors Epidemiology Jaw cysts common because of abundance of epithelial rests Odontogenic tumors from tooth-forming apparatus Only situation in pathology: primary epithelial tumor within bone Odontogenic cysts and tumors are rare 1-5% of all jaw lesions are odontogenic tumors 0.5/100,000 per year 6

7 Odontogenic cysts Benign Tumors Odontogenic epithelium only: Malignant tumors Odontogenic carcinomas: Developmental Dentigerous cyst Odontogenic keratocyst Gingival cyst of the newborn Gingival cyst of the adult Lateral periodontal cyst Calcifying odontogenic cyst Inflammatory Radicular cyst Residual cyst Squamous odontogenic tumor Calcifying epithelial odontogenic tumor Adenomatoid odontogenic tumor Odontogenic keratocyst Odontogenic epithelium & mesenchyme: Ameloblastic fibroma Odontomas - complex and compound Calcifying odontogenic cyst (and variants) Odontogenic mesenchyme: Malignant ameloblastoma Primary intraosseous squamous cell carcinoma Clear cell odontogenic carcinoma Ghost cell odontogenic carcinoma Odontogenic sarcomas: Ameloblastic fibrosarcoma Odontogenic tumors Odontogenic Fibroma Odontogenic Myxoma Cementoblastoma Frequency of odontogenic tumors Odontogenic Keratocyst Type USA China Nigeria Odontoma 68 * Odontogenic myxoma Adenomatoid odontogenic tumor Ameloblastic fibroma Pindborg tumor * % of total odontogenic tumors From dental lamina Different growth mechanism from other cysts High tendency to recur Posterior mandible, but can occur anywhere in jaws Multiple cysts feature of nevoid basal cell carcinoma (Gorlin) syndrome 7

8 Odontogenic Keratocyst: Diagnosis Thin epithelium 6-10 cell layers Refractile, parakeratotic lining Epithelial budding with daughter cysts Features are lost with inflammation Orthokeratinized odontogenic cyst Less common Not syndrome associated Low recurrence rate Nevoid Basal Cell Carcinoma Syndrome Autosomal dominant High penetrance, variable expressivity Multiple odontogenic keratocysts Multiple basal cell carcinomas Skeletal anomalies (bifid rib, hypertelorism) Intracranial calcification (falx cerebri) Characteristic facies 8

9 : Biologic Subtypes Benign, slow-growing, locally invasive neoplasm 3rd-7th decades, mean ~40 yrs, M=F Asymptomatic or painless swelling 85 % mandible, especially molar-ramus area, 15 % maxilla, mostly posterior regions Solid ameloblastoma (86%) Cystic ameloblastoma (13%) Peripheral ameloblastoma (1%) Malignant ameloblastoma Ameloblastic carcinoma 9

10 Histologic Subtypes/Patterns All subtypes mimic enamel organ Peripheral palisades & budding No hard tissue formation No clinical significance to subtypes Microscopic Desmoplastic follicular, plexiform, granular cell, acanthomatous, basaloid, spindle cell Ameloblasts SR IEE EEE DP Odontoblasts 10

11 Cystic Synonyms: unicystic ameloblastoma, plexiform unicystic ameloblastoma, ameloblastoma Younger patients 90% mandible (posterior regions) Unilocular or multilocular radiolucency Macroscopically resembles cyst Recurrence potential Cystic * Cystic ameloblastoma Multilocularity & cortical perforation >25% Recurrences with curettage >40% (1-9 yrs) * UCSF study of 21 cystic ameloblastomas 11

12 Cystic ameloblastoma 12

Origin of Odontogenic Cysts & Tumors

Origin of Odontogenic Cysts & Tumors Origin of Odontogenic Cysts & Tumors Odontogenic Apparatus Origin of Odontogenic Cysts & Tumors Odontogenic Apparatus Remnants of dental lamina Reduced enamel epithelium Odontogenic rests Basal cell layer

More information

Disclosure. Educational Objectives. Terminology. Odontogenic Cysts. Terminology

Disclosure. Educational Objectives. Terminology. Odontogenic Cysts. Terminology Disclosure Lisa J. Koenig BChD, DDS, MS Professor & Program Director, Oral Medicine and Oral Radiology Marquette University School of Dentistry Consultant to Soredex for the Scanora 3D and 3Dx Author/Editor

More information

Vascular. Extravasated blood. Melanocytic. Tattoo. Epidermolysis bullosa. Lichen planus. Pemphigoid Pemphigus Lupus. Candidosis. Surface Epithelial

Vascular. Extravasated blood. Melanocytic. Tattoo. Epidermolysis bullosa. Lichen planus. Pemphigoid Pemphigus Lupus. Candidosis. Surface Epithelial Oral Soft Tissue Pathology Epithelial Thickening (white) Combination Erythema migrans Epithelial atrophy (red) Surface Lesions Clinical Impression Enlargements Surface Debris Pigmented Vesicular Ulcerated

More information

IN THE NAME OF GOD. Dr.kheirandish DDS,MSC Oral and maxillofacial pathology

IN THE NAME OF GOD. Dr.kheirandish DDS,MSC Oral and maxillofacial pathology IN THE NAME OF GOD Dr.kheirandish DDS,MSC Oral and maxillofacial pathology ODONTOGENIC CYSTS AND TUMORS Chapter 15 I. DENTIGEROUS CYST II. III. IV. ERUPTION CYST ODONTOGENIC KERATOCYST Orthokeratinized

More information

RADIOGRAPHIC INTERPRETATION Differential Diagnosis

RADIOGRAPHIC INTERPRETATION Differential Diagnosis RADIOGRAPHIC INTERPRETATION Differential Diagnosis MODULE 1: The Introduction. Chief complaint Demographics Age Sex Race Historical findings Physical findings Clinical Radiographic Location Maxilla/mandible

More information

Odontomes and Odontogenic tumours

Odontomes and Odontogenic tumours Odontomes and Odontogenic tumours Odontomes Developmental hamartoma Hamartoma: normal tissue in abnormal location Any cells to be neoplastic it must be able to replicate, which is not seen in hamartoma

More information

Educational Cases EQA November T.J. Palmer Raigmore Hospital Inverness

Educational Cases EQA November T.J. Palmer Raigmore Hospital Inverness Educational Cases EQA November 2013 T.J. Palmer Raigmore Hospital Inverness Case 2 Clinical Details Dob 11 February 1951 PMH: 1964 Extraction of 45 aet 13 yr 1966 Cyst between 44 and 46 enucleated 1973

More information

Index. oralmaxsurgery.theclinics.com. Note: Page numbers of article titles are in boldface type.

Index. oralmaxsurgery.theclinics.com. Note: Page numbers of article titles are in boldface type. Index Note: Page numbers of article titles are in boldface type. A Adenomatoid odontogenic tumor, pediatric, 50 51 Ameloblastic carcinoma, pediatric, 17, 49 Ameloblastic fibro-odontoma, pediatric, 54 Ameloblastic

More information

Inter-radicular Radiolucencies

Inter-radicular Radiolucencies Inter-radicular Radiolucencies Differential Diagnosis Laterally Displaced Radicular Cyst Accessory canals Root fracture Lateral Periodontal Cyst Botryoid variant Odontogenic Keratocyst Incisive Canal Cyst

More information

Epithelial Sources. Rests of Serres Rests of Malassez Reduced Enamel Epithelium Surface Mucosa

Epithelial Sources. Rests of Serres Rests of Malassez Reduced Enamel Epithelium Surface Mucosa ODONTOGENIC CYSTS Epithelial Sources Rests of Serres Rests of Malassez Reduced Enamel Epithelium Surface Mucosa Epithelial Sources Surface Epithelium Rests of Serres Reduced Enamel Epithelium Rests of

More information

Salivary Glands 3/7/2017

Salivary Glands 3/7/2017 Salivary Glands 3/7/2017 Goals and objectives Focus on the entities unique to H&N Common board type facts Information for your future practice Salivary Glands Salivary Glands Major gland. Paratid. Submandibular.

More information

Differential Diagnosis of Radiolucent Lesions of the Jaws

Differential Diagnosis of Radiolucent Lesions of the Jaws Differential Diagnosis of Radiolucent Lesions of the Jaws Multilocular Multilocular Radiolucencies Odontogenic Keratocyst Botryoid Odontogenic Cyst Glandular odontogenic Cyst Invasive Ameloblastoma Central

More information

The clinical appearance and diagnosis of odontogenic cysts. SE Arc-Állcsont-Szájsebészeti és Fogászati Klinika BUDAPEST

The clinical appearance and diagnosis of odontogenic cysts. SE Arc-Állcsont-Szájsebészeti és Fogászati Klinika BUDAPEST The clinical appearance and diagnosis of odontogenic cysts SE Arc-Állcsont-Szájsebészeti és Fogászati Klinika BUDAPEST DEFINITION A cyst is a sac with walls of connective tissue, lined by epithelium, containing

More information

Proceedings of the 36th World Small Animal Veterinary Congress WSAVA

Proceedings of the 36th World Small Animal Veterinary Congress WSAVA www.ivis.org Proceedings of the 36th World Small Animal Veterinary Congress WSAVA Oct. 14-17, 2011 Jeju, Korea Next Congress: http://www.ivis.org October 14(Fri) ~ 17(Mon) 2011 ICC Jeju, Korea 2011 WSAVA

More information

Ameloblastomatous Gorlin s cyst

Ameloblastomatous Gorlin s cyst 319 Journal of Oral Science, Vol. 49, No. 4, 319-323, 2007 Case Report Ameloblastomatous Gorlin s cyst Mala Kamboj 1) and Manish Juneja 2) 1) Department of Oral Pathology and Microbiology, U.P. King George

More information

WHO Histological typing of odontogenic tumors, A. Epithelial Odontogenic Tumors

WHO Histological typing of odontogenic tumors, A. Epithelial Odontogenic Tumors Cheng-Chung Lin, Prof. in Oral Pathology College of Dental Medicine, KMU 2007 Classification: The following classification is based upon the inductive effect of one dental tissue upon another. In normal

More information

Differential Diagnosis of Oral Masses. Palatal Lesions

Differential Diagnosis of Oral Masses. Palatal Lesions Differential Diagnosis of Oral Masses Palatal Lesions Palatal Masses Periapical Abscess Torus Palatinus Mucocele Lymphoid Hyperplasia Adenomatous Hyperplasia Benign Salivary Neoplasms Malignant Salivary

More information

AMELOBLASTIC FIBROMA: A RARE CASE REPORT

AMELOBLASTIC FIBROMA: A RARE CASE REPORT Case Report International Journal of Dental and Health Sciences Volume 04, Issue 03 AMELOBLASTIC FIBROMA: A RARE CASE REPORT Namratha Patil 1 1.Sr lecturer, dept of oral medicine and radiology, KAHES VK

More information

Case Report Basal Cell Ameloblastoma of Mandible: A Rare Case Report with Review

Case Report Basal Cell Ameloblastoma of Mandible: A Rare Case Report with Review Case Reports in Dentistry Volume 2013, Article ID 187820, 4 pages http://dx.doi.org/10.1155/2013/187820 Case Report Basal Cell Ameloblastoma of Mandible: A Rare Case Report with Review Hemant Shakya, 1

More information

Morphological Variants of Ameloblastoma and Their Mimickers

Morphological Variants of Ameloblastoma and Their Mimickers 20 Jan 2012 Vol 5 No.1 North American Journal of Medicine and Science Review Morphological Variants of Ameloblastoma and Their Mimickers Khaled Shaikhi, BDS; 1 Mirdza Neiders, DDS, MS; 1 Frank Chen, MD,

More information

Glandular Odontogenic Cyst Coexisting with a Dentigerous Cyst: Case Report

Glandular Odontogenic Cyst Coexisting with a Dentigerous Cyst: Case Report SmyrnaMed Case 2018;2(1): 1-5 ISSN (Online): 2564-6869 www.smyrnamed.com Glandular Odontogenic Cyst Coexisting with a Dentigerous Cyst: Case Report Assist.Prof.Dr. Serap Keskin Tunç 1, Dt. Erkan Feslihan

More information

Differential Diagnosis of Oral Masses. Gingival Lesions

Differential Diagnosis of Oral Masses. Gingival Lesions Differential Diagnosis of Oral Masses Gingival Lesions Gingival/Alveolar Ridge Masses Parulis Periodontal Abscess Tori and Exostoses Reactive Proliferations Peripheral Odontogenic Cysts Peripheral Odontogenic

More information

Epithelial tumors. Dr. F.F. Khuzin, PhD Dr. M.O. Mavlikeev

Epithelial tumors. Dr. F.F. Khuzin, PhD Dr. M.O. Mavlikeev Epithelial tumors Dr. F.F. Khuzin, PhD Dr. M.O. Mavlikeev Epithelial tumors Tumors from the epithelium are the most frequent among tumors. There are 2 group features of these tumors: The presence in most

More information

IMAGING OF CYSTS OF THE JAWS July 2002 N. Serman

IMAGING OF CYSTS OF THE JAWS July 2002 N. Serman IMAGING OF CYSTS OF THE JAWS July 2002 N. Serman This is an area where radiology plays an important role in assisting with the diagnosis, determining the size of the lesion and the relationship to adjacent

More information

Diagnostic difficulties with lesions of the oral mucosa

Diagnostic difficulties with lesions of the oral mucosa BDIAP London, November 2010 School of Clinical Dentistry University of Sheffield Diagnostic difficulties with lesions of the oral mucosa Paul M Speight Dept Oral & Maxillofacial Pathology University of

More information

Radiographic features of cysts and benign tumors of the jaws. Cyst. Effects on adjacent structures. Types. Odontogenic Cysts. Non-Odontogenic cysts

Radiographic features of cysts and benign tumors of the jaws. Cyst. Effects on adjacent structures. Types. Odontogenic Cysts. Non-Odontogenic cysts Radiographic features of cysts and benign tumors of the jaws Cyst A Cyst is a benign pathologic cavity filled with fluid, lined by epithelium, and surrounded by a connective tissue wall Steven R. Singer,

More information

Pre-reading - radiolucencies

Pre-reading - radiolucencies Pre-reading - radiolucencies Multiple radiolucencies o Suggests a systemic cause o Most likely: cherubism or KCOT s of nevoid basal cell carcinoma syndrome o Sometimes: florid osseous dysplasia (if limited

More information

My Journey into the World of Salivary Gland Sebaceous Neoplasms

My Journey into the World of Salivary Gland Sebaceous Neoplasms My Journey into the World of Salivary Gland Sebaceous Neoplasms Douglas R. Gnepp Warren Alpert Medical School at Brown University Rhode Island Hospital Pathology Department Providence RI Asked to present

More information

Dysplasia, Mimics and Other Controversies

Dysplasia, Mimics and Other Controversies Dysplasia, Mimics and Other Controversies Mary S. Richardson, MD Dept. of Pathology Medical University of South Carolina Charleston, SC Notice of Faculty Disclosure In accordance with ACGME guidelines,

More information

AMERICAN JOURNAL OF BIOLOGICAL AND PHARMACEUTICAL RESEARCH

AMERICAN JOURNAL OF BIOLOGICAL AND PHARMACEUTICAL RESEARCH AMERICAN JOURNAL OF BIOLOGICAL AND PHARMACEUTICAL RESEARCH e-issn - 2348-2184 Print ISSN - 2348-2176 Journal homepage: www.mcmed.us/journal/ajbpr SOLID AND MULTICYSTIC FOLLICULAR AMELOBLASTOMA - A CASE

More information

高雄醫學大學 口腔醫學院 口腔病理影像科 牙科 X 光影像判讀 教學範例

高雄醫學大學 口腔醫學院 口腔病理影像科 牙科 X 光影像判讀 教學範例 高雄醫學大學 口腔醫學院 口腔病理影像科 牙科 X 光影像判讀 教學範例 Content Image No. 001 Dentigerous cyst over left upper embedded canine--------------------- 頁 1 Image No. 002---------------------------------------------------------------

More information

04/09/2018. Squamous Cell Neoplasia and Precursor Lesions. Agenda. Squamous Dysplasia. Squamo-proliferative lesions. Architectural features

04/09/2018. Squamous Cell Neoplasia and Precursor Lesions. Agenda. Squamous Dysplasia. Squamo-proliferative lesions. Architectural features Squamous Cell Neoplasia and Precursor Lesions Jennifer L. Hunt, MD, MEd Aubrey J. Hough Jr, MD, Endowed Professor of Pathology Chair of Pathology and Laboratory Medicine University of Arkansas for Medical

More information

NEOPLASIA-I CANCER. Nam Deuk Kim, Ph.D.

NEOPLASIA-I CANCER. Nam Deuk Kim, Ph.D. NEOPLASIA-I CANCER Nam Deuk Kim, Ph.D. 1 2 Tumor in the hieroglyphics of the Edwin Smith papyrus (1,600 B.C., Breasted s translation 1930) 3 War on Cancer (National Cancer Act, 1971) 4 Cancer Acts in Korea

More information

Premalignant lesions may expose to a promoting. factor & may be induced to undergo malignant. Carcinoma in situ displays the cytologic features of

Premalignant lesions may expose to a promoting. factor & may be induced to undergo malignant. Carcinoma in situ displays the cytologic features of بسم رلاهللا Def. Premalignant lesions may expose to a promoting factor & may be induced to undergo malignant transformation. Carcinoma in situ displays the cytologic features of malignancy without invasion

More information

Basal cell carcinoma 5/28/2011

Basal cell carcinoma 5/28/2011 Goal of this Presentation A practical approach to the diagnosis of cutaneous carcinomas and their mimics Thaddeus Mully, MD University of California San Francisco To review common non-melanoma skin cancers

More information

Pericoronal radiolucency associated with incomplete crown

Pericoronal radiolucency associated with incomplete crown Imaging Science in entistry 2013; 43: 295-301 http://dx.doi.org/10.5624/isd.2013.43.4.295 Pericoronal radiolucency associated with incomplete crown Kyung-Soo Nah 1, * 1 epartment of Oral and Maxillofacial

More information

MANSOURA UNIVERSITY FACULTY OF DENTISTRY ORAL PATHOLOGY DEPT

MANSOURA UNIVERSITY FACULTY OF DENTISTRY ORAL PATHOLOGY DEPT MANSOURA UNIVERSITY FACULTY OF DENTISTRY ORAL PATHOLOGY DEPT THIRD YEAR Course Director: Dr. Nadia M. Lotfy Professor of Oral Pathology Dr. Manal Mohamed Zyada Associate Professor of Oral Pathology Oral

More information

Salivary Gland Pathology

Salivary Gland Pathology IN THE NAME OF GOD Salivary Gland Pathology CHAPTER 11 Dr.kheirandish Oral and maxillofacial pathology Sialadenosis Adenomatoid Hyperplasia of the Minor Salivary Glands Necrotizing Sialometaplasia Pleomorphic

More information

Salivary Gland Cytology

Salivary Gland Cytology Salivary Gland Cytology Diagnostic challenges and potential pitfalls Tarik M. Elsheikh, MD Professor and Medical Director Anatomic Pathology Cleveland Clinic FNA Salivary Gland Lesions Indications Distinguish

More information

Keratocystic Odontogenic Tumor : What radiologist needs to know?

Keratocystic Odontogenic Tumor : What radiologist needs to know? Keratocystic Odontogenic Tumor : What radiologist needs to know? Poster No.: C-0444 Congress: ECR 2014 Type: Authors: Keywords: DOI: Educational Exhibit K. El Karzazi, J. M. Villanueva Rincón, R. Corrales,

More information

International Journal of Health Sciences and Research ISSN:

International Journal of Health Sciences and Research   ISSN: International Journal of Health Sciences and Research www.ijhsr.org ISSN: 2249-9571 Case Report Orthokeratinized Odontogenic Cyst: A Case Report- A Milder Variant of OKC or an Independent Entity Mariyam

More information

Odontogenic tumors: a review

Odontogenic tumors: a review Periodontology 2000, Vol. 57, 2011, 160 176 Printed in Singapore. All rights reserved Ó 2011 John Wiley & Sons A/S PERIODONTOLOGY 2000 Odontogenic tumors: a review PETER R. MORGAN Odontogenic tumors comprise

More information

Diseases of oral cavity

Diseases of oral cavity Diseases of oral cavity Diseases of Teeth and Supporting Structures Inflammatory/Reactive Lesions Infections Oral Manifestations of Systemic Disease Precancerous and Cancerous Lesions Odontogenic Cysts

More information

Differential Diagnosis of Oral Lesions. An Interactive Lecture Using Audience Response Polling. John L. Alonge, MS, DDS

Differential Diagnosis of Oral Lesions. An Interactive Lecture Using Audience Response Polling. John L. Alonge, MS, DDS Differential Diagnosis of Oral Lesions An Interactive Lecture Using Audience Response Polling John L. Alonge, MS, DDS Goals 1. Review the diagnostic process needed to formulate a differential diagnosis

More information

Course Description 343 DDS- Clinical Oral and Maxillofacial Radiology II ( )

Course Description 343 DDS- Clinical Oral and Maxillofacial Radiology II ( ) King Saud University College of Dentistry Dept. of Oral Medicine & Diagnostic Sciences Division of Oral & Maxillofacial Radiology Course Description 343 DDS- Clinical Oral and Maxillofacial Radiology II

More information

MULTILOCULAR AMELOBLASTOMA OF MANDIBLE-A CASE REPORT

MULTILOCULAR AMELOBLASTOMA OF MANDIBLE-A CASE REPORT International Journal of Advancements in Research & Technology, Volume 2, Issue2, February-2013 1 MULTILOCULAR AMELOBLASTOMA OF MANDIBLE-A CASE REPORT DR SANTOSH KUMAR SUBUDHI*, DR SUMIT DASH**, DR.K..PREMANANDA***,

More information

Treatment Modalities of Odontogenic Keratocyst of Maxilla and Mandible: Our Experience

Treatment Modalities of Odontogenic Keratocyst of Maxilla and Mandible: Our Experience wjd Parveen Akhter Lone et al Original Research 10.5005/jp-journals-10015-1344 Treatment Modalities of Odontogenic Keratocyst of Maxilla and Mandible: Our Experience 1 Parveen Akhter Lone, 2 Mohan Singh,

More information

Diseases of the breast (1 of 2)

Diseases of the breast (1 of 2) Diseases of the breast (1 of 2) Introduction A histology introduction Normal ducts and lobules of the breast are lined by two layers of cells a layer of luminal cells overlying a second layer of myoepithelial

More information

Cutaneous Adnexal Tumors

Cutaneous Adnexal Tumors Cutaneous Adnexal Tumors Lesions with Predominant Follicular Differentiation Special Emphasis on Basal Cell Carcinoma 2014-04-01 Prof. Dr. med. Katharina Glatz Pathologie Cutaneous Adnexal Tumors Hair

More information

Oral Tumors in Dogs Gingival Enlargement

Oral Tumors in Dogs Gingival Enlargement Oral Tumors in Dogs Is that lump you re seeing in your dog s mouth normal? Or is it something to be concerned about? The easiest way to know for sure is to have it evaluated by a veterinarian. When you

More information

Index. Note: Page numbers of article titles are in boldface type.

Index. Note: Page numbers of article titles are in boldface type. Note: Page numbers of article titles are in boldface type. A Actinomycosis, 200 201 Adenoid cystic carcinoma, 148 150 Adenomatoid odontogenic tumors, 134, 135 Ameloblastic fibro-odontoma, 134 Ameloblastoma,

More information

A neoplasm is defined as "an abnormal tissue proliferation, which exceeds that of adjacent normal tissue. This proliferation continues even after

A neoplasm is defined as an abnormal tissue proliferation, which exceeds that of adjacent normal tissue. This proliferation continues even after NEOPLASIA Neoplasia is a very important topic in pathology because neoplasms are both common and serious diseases. A neoplasm literally means a new growth, and this term is used interchangeably with a

More information

Oral Cancer Risk and Detection

Oral Cancer Risk and Detection Oral Cancer Risk and Detection Evan M. Graboyes, MD Assistant Professor Department of Otolaryngology-Head & Neck Surgery Cancer Control Program, Hollings Cancer Center Medical University of South Carolina

More information

Common/Important Radiolucencies. B. Most Common Location Apex of permanent first molar, rare in primary teeth.

Common/Important Radiolucencies. B. Most Common Location Apex of permanent first molar, rare in primary teeth. Cincinnati Dental Association Breakfast at Tiffany s: The Jewels and Gems of Oral Pathology November 17, 2010 John A. Svirsky, DDS, MEd Virginia Commonwealth University 804-828-0547 FAX: 804-828-6234 EMAIL:

More information

Lesions Mimicking Adenoid Cystic Carcinoma. Diagnostic Problems in Salivary Gland Pathology An Update 5/29/2009

Lesions Mimicking Adenoid Cystic Carcinoma. Diagnostic Problems in Salivary Gland Pathology An Update 5/29/2009 Diagnostic Problems in Salivary Gland Pathology An Update Lesions Mimicking Adenoid Cystic Carcinoma Stacey E. Mills, M.D. W.S. Royster Professor of Pathology Director of Surgical and Cytopathology University

More information

Case Report Intraosseous Follicular Adenomatoid Odontogenic Tumour A Case Report

Case Report Intraosseous Follicular Adenomatoid Odontogenic Tumour A Case Report International Dentistry Volume 2009, Article ID 597483, 4 pages doi:10.1155/2009/597483 Case eport Intraosseous Follicular Adenomatoid Odontogenic Tumour A Case eport Farhan Durrani 1 and oyana Singh 2

More information

Histopathological study of neoplastic lesions of oral cavity and oropharynx

Histopathological study of neoplastic lesions of oral cavity and oropharynx International Journal of Research in Medical Sciences Gupta M et al. Int J Res Med Sci. 2016 May;4(5):1506-1510 www.msjonline.org pissn 2320-6071 eissn 2320-6012 Research Article DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20161219

More information

Maxilla and mandible benign lesions: Radiologic Findings and Differential Diagnosis in CT

Maxilla and mandible benign lesions: Radiologic Findings and Differential Diagnosis in CT Maxilla and mandible benign lesions: Radiologic Findings and Differential Diagnosis in CT Poster No.: C-0964 Congress: ECR 2012 Type: Scientific Exhibit Authors: N. Lopez 1, E. Marcos Naranjo 2, M. D.

More information

Mody. AIS vs. Invasive Adenocarcinoma of the Cervix

Mody. AIS vs. Invasive Adenocarcinoma of the Cervix Common Problems in Gynecologic Pathology Michael T. Deavers, M.D. Houston Methodist Hospital, Houston, Texas Common Problems in Gynecologic Pathology Adenocarcinoma in-situ (AIS) of the Cervix vs. Invasive

More information

number Done by Corrected by Doctor Maha Shomaf

number Done by Corrected by Doctor Maha Shomaf number 16 Done by Waseem Abo-Obeida Corrected by Zeina Assaf Doctor Maha Shomaf MALIGNANT NEOPLASMS The four fundamental features by which benign and malignant tumors can be distinguished are: 1- differentiation

More information

Jaws: Cysts and Odontogenic Neoplasms

Jaws: Cysts and Odontogenic Neoplasms Topic 10: Jaw Cysts General Features of Jaw Cysts Sources of Epithelium in Cysts Radiographic Features of Jaw Cysts Microscopic Features of Jaw Cysts Treatment and Prognosis of Jaw Cysts Classification

More information

An unusual site of Adenomatoid Odontogenic Tumor: A rare case report

An unusual site of Adenomatoid Odontogenic Tumor: A rare case report J. Int Oral Health 2010 Case Report All right reserved An unusual site of Adenomatoid Odontogenic Tumor: A rare case report Sapna Panjwani*, Anjana Bagewadi**, Vaishali Keluskar*** *Post Graduate Student

More information

PACIFIC JOURNAL OF MEDICAL SCIENCES ISSN:

PACIFIC JOURNAL OF MEDICAL SCIENCES ISSN: PACIFIC JOURNAL OF MEDICAL SCIENCES {Formerly: Medical Sciences Bulletin} ISSN: 2072 1625 Pac. J. Med. Sci. (PJMS) www.pacjmedsci.com. Email: pacjmedsci@gmail.com. ADENOMATOID ODONTOGENIC TUMOR WITH RARE

More information

Mucous and ciliated cell metaplasia in epithelial linings of odontogenic inflammatory and developmental cysts

Mucous and ciliated cell metaplasia in epithelial linings of odontogenic inflammatory and developmental cysts 77 Journal of Oral Science, Vol. 47, No. 2, 77-81, 2005 Original Mucous and ciliated cell metaplasia in epithelial linings of odontogenic inflammatory and developmental cysts Yasunori Takeda, Yuko Oikawa,

More information

POSTGRADUATE INSTITUTE OF MEDICINE UNIVERSITY OF COLOMBO SELECTION EXAMINATION IN MP (ORAL & MAXILLOFACIAL SURGERY) - OCTOBER 2014

POSTGRADUATE INSTITUTE OF MEDICINE UNIVERSITY OF COLOMBO SELECTION EXAMINATION IN MP (ORAL & MAXILLOFACIAL SURGERY) - OCTOBER 2014 POSTGRADUATE INSTITUTE OF MEDICINE UNIVERSITY OF COLOMBO SELECTION EXAMINATION IN MP (ORAL & MAXILLOFACIAL SURGERY) - OCTOBER 2014 Date :- 15 th October 2014 PAPER I Answer three (03) questions from each

More information

Case Report Unicystic Ameloblastoma with Mural Proliferation Managed by Conservative Treatment

Case Report Unicystic Ameloblastoma with Mural Proliferation Managed by Conservative Treatment Case Reports in Pathology Volume 2016, Article ID 3089540, 4 pages http://dx.doi.org/10.1155/2016/3089540 Case Report Unicystic Ameloblastoma with Mural Proliferation Managed by Conservative Treatment

More information

Squamous Cell Carcinoma Arising in a Residual Cyst: A Case Report

Squamous Cell Carcinoma Arising in a Residual Cyst: A Case Report Squamous Cell Carcinoma Arising in a Residual Cyst: A Case Report Abstract Aim: The purpose of this report is to present a case of squamous cell carcinoma (SCC) arising from a mandibular residual cyst.

More information

Course Description 343 DDS- Clinical Oral and Maxillofacial Radiology II ( )

Course Description 343 DDS- Clinical Oral and Maxillofacial Radiology II ( ) King Saud University College of Dentistry Dept. of Oral Medicine & Diagnostic Sciences Division of Oral & Maxillofacial Radiology Course Description 343 DDS- Clinical Oral and Maxillofacial Radiology II

More information

Squamous Cell Neoplasia and Precursor Lesions

Squamous Cell Neoplasia and Precursor Lesions Squamous Cell Neoplasia and Precursor Lesions Jennifer L. Hunt, MD, MEd Aubrey J. Hough Jr, MD, Endowed Professor of Pathology Chair of Pathology and Laboratory Medicine University of Arkansas for Medical

More information

Diagnostically Challenging Cases in Gynecologic Pathology

Diagnostically Challenging Cases in Gynecologic Pathology Diagnostically Challenging Cases in Gynecologic Pathology Eric C. Huang, M.D., Ph.D. Department of Pathology and Laboratory Medicine University of California, Davis Medical Center Case 1 Presentation 38

More information

Course Description 343 DDS- Clinical Oral and Maxillofacial Radiology II ( )

Course Description 343 DDS- Clinical Oral and Maxillofacial Radiology II ( ) King Saud University College of Dentistry Dept. of Oral Medicine & Diagnostic Sciences Division of Oral & Maxillofacial Radiology Course Description 343 DDS- Clinical Oral and Maxillofacial Radiology II

More information

BREAST PATHOLOGY. Fibrocystic Changes

BREAST PATHOLOGY. Fibrocystic Changes BREAST PATHOLOGY Lesions of the breast are very common, and they present as palpable, sometimes painful, nodules or masses. Most of these lesions are benign. Breast cancer is the 2 nd most common cause

More information

SQUAMOUS ODONTOGENIC TUMOUR: REPORT OF FIVE CASES FROM NIGERIA AND REVIEW OF LITERATURE

SQUAMOUS ODONTOGENIC TUMOUR: REPORT OF FIVE CASES FROM NIGERIA AND REVIEW OF LITERATURE African Journal of Oral Health Volume 3 Numbers 1&2, 2006:1-5 REFEREED ARTICLE SQUAMOUS ODONTOGENIC TUMOUR: REPORT OF FIVE CASES FROM NIGERIA AND REVIEW OF LITERATURE Adebiyi K.E., Odukoya O., Taiwo, E.O.

More information

CYSTS OF THE JAW AND SOFT TISSUES

CYSTS OF THE JAW AND SOFT TISSUES CYSTS OF THE JAW AND SOFT TISSUES Definition: it is a pathological cavity lined by epithelium containing fluid or semifluid (true cyst). If the cyst not lined by epithelium it is pseudo- cyst. Classification

More information

SESSION 1: GENERAL (BASIC) PATHOLOGY CONCEPTS Thursday, October 16, :30am - 11:30am FACULTY COPY

SESSION 1: GENERAL (BASIC) PATHOLOGY CONCEPTS Thursday, October 16, :30am - 11:30am FACULTY COPY SESSION 1: GENERAL (BASIC) PATHOLOGY CONCEPTS Thursday, October 16, 2008 9:30am - 11:30am FACULTY COPY GOAL: Describe the basic morphologic (structural) changes which occur in various pathologic conditions.

More information

We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists. International authors and editors

We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists. International authors and editors We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists 3,500 108,000 1.7 M Open access books available International authors and editors Downloads Our

More information

Calcifying Odontogenic Cyst with Complex Odontoma: Histological and Immunohistochemical Features

Calcifying Odontogenic Cyst with Complex Odontoma: Histological and Immunohistochemical Features Case Report Calcifying Odontogenic Cyst with Complex Odontoma: Histological and Immunohistochemical Features Nooshin Mohtasham 1, Amin Rahpeyma 2, Saeedeh Khajeh Ahmadi 3, Mohsen Merati 4 1 Oral and Maxillofacial

More information

An Expansile Large Odontogenic Keratocyst Maxilla: A Case Report.

An Expansile Large Odontogenic Keratocyst Maxilla: A Case Report. RESEARCH AND REVIEWS: JOURNAL OF DENTAL SCIENCES An Expansile Large Odontogenic Keratocyst Maxilla: A Case Report. Nasib Chand Khabra 1, Ish Pandhi 1 *, Kiran DN 2, Sunil Alipuria 1, Bhawna Gulati 1, and

More information

PATHOLOGY OF THE MANDIBLE

PATHOLOGY OF THE MANDIBLE PATHOLOGY OF THE MANDIBLE BOTOND TIMÁR 2017.03.13 The material of the lecture is exclusively for university teaching! MICROGNATHIA / RETROGNATHISM Retrognathism: is a type of malocclusion which refers

More information

Salivary gland tumor cytologic and histologic correlation: Algorithmic and risk stratification based approaches

Salivary gland tumor cytologic and histologic correlation: Algorithmic and risk stratification based approaches Salivary gland tumor cytologic and histologic correlation: Algorithmic and risk stratification based approaches Christopher C. Griffith, MD, PhD Raja R. Seethala, MD 1. Salivary gland tumor cytology: A

More information

Glandular odontogenic cyst associated with ameloblastoma: Case report and review of the literature

Glandular odontogenic cyst associated with ameloblastoma: Case report and review of the literature Journal section: Oral Medicine and Pathology Publication Types: Case Report doi:10.4317/jced.53775 http://dx.doi.org/10.4317/jced.53775 : Case report and review of the literature Timothée Cousin 1, Samuel

More information

Ameloblastic Carcinoma of the Mandible: a Rare Case Report

Ameloblastic Carcinoma of the Mandible: a Rare Case Report IBIMA Publishing Journal of Research and Practice in Dentistry http://www.ibimapublishing.com/journals/dent/dent.html Vol. 2015 (2015), Article ID 672596, 6 pages DOI: 10.5171/2015.672596 Case Report Ameloblastic

More information

The resident will be assigned to be on call with the Oral and Maxillofacial service. Call will be set according to PARO guidelines.

The resident will be assigned to be on call with the Oral and Maxillofacial service. Call will be set according to PARO guidelines. Goals and Objectives for the Otolaryngology-Head & Neck Resident on the Oral and Maxillofacial Surgery (OMFS) Rotation St. Catharines General Hospital (1 four-week rotational block) During the second year

More information

Acanthomatous Ameloblastoma- A Case Report

Acanthomatous Ameloblastoma- A Case Report Acanthomatous Ameloblastoma- A Case Report Geeta Singh 1, Rashmi Agarwal 2, Vimlesh Kumar 3, Deepak Passi 4 1 Assistant Professor, Department of Oral & Maxillofacial Surgery, King George Dental University,

More information

MALIGNANT TUMOURS OF THE JAWS

MALIGNANT TUMOURS OF THE JAWS MALIGNANT TUMOURS OF THE JAWS MALIGNANT TUMOURS OF THE JAWS Squamous cell carcinoma Osteogenic sarcoma Chondrosarcoma Fibrosarcoma Malignant lymphomas (incl. Burkitt s) Multiple myeloma Ameloblastoma Secondary

More information

A CLINICOPATHOLOGIC STUDY OF ODONTOGENIC KERATOCYST (OKC) AND THE ROLE OF AgNORs IN CELL PROLIFERATION

A CLINICOPATHOLOGIC STUDY OF ODONTOGENIC KERATOCYST (OKC) AND THE ROLE OF AgNORs IN CELL PROLIFERATION A CLINICOPATHOLOGIC STUDY OF ODONTOGENIC KERATOCYST (OKC) AND THE ROLE OF AgNORs IN CELL PROLIFERATION * Vindhya Savithri **Sudha S ***Shameena P.M ****Ipe Varghese Abstract : The histologic pattern of

More information

Polymorphous Low-Grade. December 5 th, 2008

Polymorphous Low-Grade. December 5 th, 2008 Polymorphous Low-Grade Adenocarcinoma December 5 th, 2008 Epidemiology Represents 2 nd or 3 rd most common minor salivary gland malignancy (17-26%) 1 st mucoepidermoid carcinoma Rare in reported Asian

More information

Head and Neck Squamous Subtypes

Head and Neck Squamous Subtypes 1 Head and Neck Squamous Subtypes Adel K. El-Naggar, M.D., Ph.D. The University of Texas MD Anderson Cancer Center, Houston, Texas HNSCC 5 th -6 th most common cancer 400,000/year 50% mortality Considerable

More information

Histologic Variants of Calcifying Odontogenic Cyst: A Study of 52 Cases

Histologic Variants of Calcifying Odontogenic Cyst: A Study of 52 Cases ORIGINAL RESEARCH 10.5005/jp-journals-10024-2108 Histologic Variants of Calcifying Odontogenic Cyst: A Study of 52 Cases 1 Soussan Irani, 2 Forough Foroughi ABSTRACT Aim: This study aimed at evaluating

More information

Calcifying Cystic Odontogenic Tumor: Review with Discussion

Calcifying Cystic Odontogenic Tumor: Review with Discussion DOI 10.7603/s40782-014-0006-9 GST International Journal of Advances in edical Research (JAR) Vol.1.1, ay 2014 Calcifying Cystic Odontogenic Tumor: Review with Discussion Dr. Ritika Jindal BDS, 1 Dr. Ravikiran

More information

PLEOMORPHIC ADENOMA ( BENIGN MIXED TUMOR )

PLEOMORPHIC ADENOMA ( BENIGN MIXED TUMOR ) ( BENIGN MIXED TUMOR ) Grossly, the tumor is freely movable, solid, sometimes lobulated and occasionally cystic. If recurrent, multinodular masses are common. Histologically, within a fibrous capsule,

More information

DISORDERS OF THE SALIVARY GLANDS Neoplasms Dr.M.Baskaran Selvapathy S IV

DISORDERS OF THE SALIVARY GLANDS Neoplasms Dr.M.Baskaran Selvapathy S IV DISORDERS OF THE SALIVARY GLANDS Neoplasms Dr.M.Baskaran Selvapathy S IV NEOPLASMS A) Epithelial I. Benign Pleomorphic adenoma( Mixed tumour) Adenolymphoma (Warthin s tumour) Oxyphil adenoma (Oncocytoma)

More information

Annals and Essences of Dentistry

Annals and Essences of Dentistry aedj.2014.6.3.2.4 Central Calcifying Cystic Odontogenic Tumor Of Mandible A Case Report 1 Rajasekhar Gali 2 Madan Mohan Reddy 3 Vandana Raghunath 4 Sajan Anand 1 Associate Professor 2 Reader 3 Professor

More information

A COMPARATIVE HISTOPATHOLOGICAL STUDY OF EPITHELIAL linings OF ODONTOGENIC CYSTS AND UNICYSTIC AMElOBlASTOMAS

A COMPARATIVE HISTOPATHOLOGICAL STUDY OF EPITHELIAL linings OF ODONTOGENIC CYSTS AND UNICYSTIC AMElOBlASTOMAS A COMPARATIVE HISTOPATHOLOGICAL STUDY OF EPITHELIAL linings OF ODONTOGENIC CYSTS AND UNICYSTIC AMElOBlASTOMAS J Sudiono, RB Zain. A Comparative Histopathological Study of Epithelial Linings of Odontogenic

More information

Case Report Ameloblastic Fibroodontoma of the Mandible with Normal Karyotype in a Pediatric Patient

Case Report Ameloblastic Fibroodontoma of the Mandible with Normal Karyotype in a Pediatric Patient Case Reports in Dentistry Volume 2012, Article ID 969687, 4 pages doi:10.1155/2012/969687 Case Report Ameloblastic Fibroodontoma of the Mandible with Normal Karyotype in a Pediatric Patient Esther Manor,

More information

Cytyc Corporation - Case Presentation Archive - March 2002

Cytyc Corporation - Case Presentation Archive - March 2002 FirstCyte Ductal Lavage History: 68 Year Old Female Gail Index: Unknown Clinical History: Negative Mammogram in 1995 6 yrs. later presents with bloody nipple discharge Subsequent suspicious mammogram Suspicious

More information

Case Report A Giant Cell Fibroma and Focal Fibrous Hyperplasia in a Young Child: A Case Report

Case Report A Giant Cell Fibroma and Focal Fibrous Hyperplasia in a Young Child: A Case Report Hindawi Publishing Corporation Case Reports in Dentistry Volume 2012, Article ID 370242, 5 pages doi:10.1155/2012/370242 Case Report A Giant Cell Fibroma and Focal Fibrous Hyperplasia in a Young Child:

More information

SYLLABUS FOR EXAMINATION OF PRECLINICS IN ORAL AND MAXILLOFACIAL SURGERY

SYLLABUS FOR EXAMINATION OF PRECLINICS IN ORAL AND MAXILLOFACIAL SURGERY SYLLABUS FOR EXAMINATION OF PRECLINICS IN ORAL AND MAXILLOFACIAL SURGERY 1. Asepsis and antisepsis in the oral and maxillofacial surgery. Preparation of the hands of the surgeon and the operative field

More information

Histopathology: Cervical HPV and neoplasia

Histopathology: Cervical HPV and neoplasia Histopathology: Cervical HPV and neoplasia These presentations are to help you identify basic histopathological features. They do not contain the additional factual information that you need to learn about

More information