Appendix H: Study characteristics: Fungal infections, Mycoses. The Epidemiology of Skin Conditions in the Aged: A Systematic Review.

Transcription

1 Appendix H: Study characteristics: Fungal infections, Mycoses Article title: Journal: The Epidemiology of Skin Conditions in the Aged: A Systematic Review. Journal of Tissue Viability 1

2 Nr. Source (Author and year) 1 Ananae et al [1] 2 Bartholomeeusen 2007 [2] 3 Baddley 2011 [3] 4 Brilhante 2005 [4] Country Tunisia Belgium USA Brazil Design/ Measure Secondary data analysis/ Incidence Secondary data analysis/ Incidence Setting Inclusion criteria Sample characteristics Results Remarks Risk of bias Domesticity - >65 - Onichodystrophy of hand or nails : 1 2. N = Age: >65 ; mean age: 72.3 Not reported : N = Age groups: 65-74; Having full Medicare coverage for at least 13 consecutive months - Living in one of the 50 US- States or Washington DC - Not having claims for any endemic mycosis during a 12 month period Clinical lesions of the nails 1. N = Age: Gender: / % female : 1 Onychomycosis: Clinical: 120/290, 41.4% Laboratory confirmed: 97/290, 33.5% Skin lesions: 79/290, 27.2% - Interdigital mycoses 65/79, 82.3% - Plantar hyperkeratosis: 24/79, 31.7% Erysipelas incidence rate per 1000 patient: : 2.89 n= 32 (65-74); 3.11 n= 23 ( 75) : 4.14 n= 63 (65-74); 6.80 n= 101 ( 75) Incidence of endemic mycoses: 775/ , 0.04% Histoplasmosis: n= 357, 3.4% Coccidioidomycosis: n= 345, 3.2% Blastomycosis: n= 74, 0.7% Onychomycosis: 70-79: 29% female; 17% male > 80: 9% female; 4% male - N: recalculated table #2 n.a. - n.a. 2

3 5 Costa- Orlandi et al [5] 6 Djeridane 2006 [6] 7 Gunduz et al [7] Brazil Algeria Turkey Tinea pedis: 8/70, 11.4% - Hospital - No treatment with topic drugs 14 days before or oral medications 30 days before - No patients presenting lesions or use any kind of substance on the lesion for 14 days - Informed consent (total: 976) 3. Age groups: 70-79; >80 institutions: 1 (total: 189) 3. Age groups: 71-80, 81-90, Hospital Not reported institutions: 1 2. N = Age: >70 4. Gender: 100% male Long-term care Informed consent institutions: 3 2. N = Age: 65-97, mean age: Gender: 59/ % female Dermatomycosis: 71-80: C.parapsilosis 2.5%; T.rubrum 2.5% 81-90: C.tropicalis 2%; T. interdigitale 2% : Trichosporon spp. 2% figure #1 figure #1 Onychomycosis: 102/214, 47.7% Gender: recalculated text (p.173) 3

4 8 Nakagami 2014 [8] 9 Nkjondo Minkoumou 2012 [9] 10 Panackal 2009 [10] Japan USA Cameroon Secondary data analysis/ Long-term care - Informed consent - Approval of the primary physician institutions: 3 2. N = Mean age per facility: 85.0 (SD 9.7); 86.8 (SD 7.2); 87.5 (SD 7.1) 4. Gender: 137/ % female Hospital Not reported institutions: 2 2. N = 5 3. Age: 71, mean age: Gender: 1/5, 20% female Home care Not reported institutions: n.a. of skin eruptions: Buttock: 124/171, 72.5% - Scale: 104/171, 60.8% - Erythema: 65/171, 38% - Maceration: 7/171, 4.1% - Erosion: 5/171, 2.9% Nail: 167/173, 96.5% - Discoloration: 100/173, 57.8% - Pachyonychia: 97/173, 56.1% - Hyperkeratosis: 76/173, 43.9% Interdigits: 156/173, 90.2% - Scale: 156/173, 90.2% Plantar: 125/173, 72.3% - Scale: 79/173, 45.7% - Hyperkeratosis: 59/173, 34.1% Mycosis: Buttock: - Tinea 6/124, 4.8% - Candidiasis2/124, 2.4% Nail: - Tinea ungium 95/163, 58.3% Interdigits: - Tinea pedis 34/151, 22.5% Plantar: - Tinea pedis 38/121, 31.4% Gender: recalculated table #1 Low Onychomycosis: 2/5, 40% - of cutaneous fungal infections: Tinea ungium: 14.6% - Tinea pedis: 8.8% - n.a. 4

5 11 Piérard 2001 [11] 12 Sadeghi 2011 [12] 13 Watanabe et. al 2010 [13] Belgium Iran Japan Longitudinal /, Incidence 2. N= not reported (total: ) 3. Age groups: 65-74; 75 Not reported institutions: data from 16 European countries (total: ) 3. Age: > 64 Home care Not reported institutions: 1 (total: 4871) 3. Age groups: 70-79; All cases who visited a dermatologist in the investigational period institutions: unclear (total: ) 3. Age groups: 70-79,80-89, >90 - Tinea capitis: 0.7% - Tinea corporis: 3.8% - Tinea cruris: 6.8% 75 - Tinea ungium: 11.9% - Tinea pedis: 6.1% - Tinea corporis: 1.5% - Tinea cruris: 3.4% Incidence tinea pedis + onychomycosis: 25.7% Dermatomycosis 70-79: Dermatophytes 40%, Candida spp. 20%, Mould 7%, Malessezia spp. 2.5% 80-89: Dermatophytes 29%, Candida spp. 20%, Mould 6%, Malessezia spp. 1% Male 1999/2000: Fungal infection: 70 : 54%; 80 : 52%; 90 : 50% Tinea pedis only: 70 : 24%; 80 : 19,5%; 90 : 16% Tinea unguium only: 70 : 7%; 80 : 8,5%; 90 : 10,5% Tinea pedis+ tinea unguium: 70 : 26%; 80 : 25%; 90 : 29% Female 1999/2000: not calculable for 65+ figure #1 figure #4 High 5

6 institutions:361 (total: 7783) 3. Age groups: 70-79,80-89, >90 1. Gender: unclear Fungal infection: 70 : 50%; 80 : 49%; 90 : 45% Tinea pedis only: 70 : 22%; 80 : 19,5%; 90 : 12% Tinea unguium only: 70 : 9%; 80 : 8,5%; 90 : 9,5% Tinea pedis+ tinea unguium: 70 : 20%; 80 : 20,5%; 90 : 22,5% Male 2006: Fungal infection: 70 : 63%; 80 : 64%; 90 : 58% Tinea pedis only: 70 : 23%; 80 : 24%; 90 : 18% Tinea unguium only: 70 : 11,5%; 80 : 12%; 90 : 14% Tinea pedis+ tinea unguium: 70 : 27%; 80 : 28%; 90 : 29,5% Female 2006: Fungal infection: 70 : 51%; 80 : 51,5%; 90 : 60% Tinea pedis only: 70 : 21%; 80 : 22,5%; 90 : 20% Tinea unguium only: 70 : 12%; 80 : 13%; 90 : 13,5% Tinea pedis+ tinea unguium: 70 : 19%; 80 : 17%; 90 : 21,5% 6

7 References Appendix H 1. Anane S, Chtourou O, Chedi A, Triki S, Belhaj S, Kaouech E, Kallel K, Chaker E. [Onychomycosis in the elderly]. Ann Dermatol Venereol (10 Pt 1): Bartholomeeusen S, Vandenbroucke J, Truyers C, Buntinx F. Epidemiology and comorbidity of erysipelas in primary care. Dermatology (2): Baddley JW, Winthrop KL, Patkar NM, Delzell E, Beukelman T, Xie F, Chen L, Curtis JR. Geographic distribution of endemic fungal infections among older persons, United States. Emerging Infectious Diseases (9): Brilhante RSN, Cordeiro RA, Medrano DJA, Rocha MFG, Monteiro AJ, Cavalcante CSP, Meireles TEF, Sidrim JJC. Onychomycosis in Ceara (Northeast Brazil): epidemiological and laboratory aspects. Memorias do Instituto Oswaldo Cruz (2): Costa-Orlandi CB, Magalhaes GM, Oliveira MB, Taylor ELS, Marques CRS, de Resende-Stoianoff MA. of dermatomycosis in a Brazilian tertiary care hospital. Mycopathologia (5-6): Djeridane A, Djeridane Y, Ammar-Khodja A. Epidemiological and aetiological study on tinea pedis and onychomycosis in Algeria. Mycoses (3): Gunduz T, Gunduz K, Degerli K, Limoncu ME. Epidemiological profile of onychomycosis in the elderly living in the nursing homes. European Geriatric Medicine : Nakagami G, Takehara K, Kanazawa T, Miura Y, Nakamura T, Kawashima M, Tsunemi Y, Sanada H. The prevalence of skin eruptions and mycoses of the buttocks and feet in aged care facility residents: a cross-sectional study. Arch Gerontol Geriatr (2): DOI /j.archger Nkondjo Minkoumou S, Fabrizi V, Papini M. Onychomycosis in Cameroon: a clinical and epidemiological study among dermatological patients. Int J of Dermatol (12): Panackal AA, Halpern EF, Watson AJ. Cutaneous fungal infections in the United States: Analysis of the national ambulatory medical care survey (NAMCS) and national hospital ambulatory medical care survey (NHAMCS), International Journal of Dermatology (7): Pierard G. Onychomycosis and other superficial fungal infections of the foot in the elderly: A pan-european survey. Dermatology (3): Sadeghi G, Abouei M, Alirezaee M, Tolouei R, Shams-Ghahfarokhi M, Mostafavi E, Razzaghi-Abyaneh M. A 4-year survey of dermatomycoses in Tehran from 2006 to Journal de Mycologie e (4): Watanabe S, Harada T, Hiruma M, Iozumi K, Katoh T, Mochizuki T, Naka W, Japan Foot Week, Group. Epidemiological survey of foot diseases in Japan: results of 30,000 foot checks by dermatologists. J of Dermatol (5):