Session Summary session 6. Reactive Lymphoproliferations of the skin. Session 6 - case 211

Size: px
Start display at page:

Download "Session Summary session 6. Reactive Lymphoproliferations of the skin. Session 6 - case 211"

Transcription

1 SH/EAHP Workshop 2011 Los Angeles, California, USA October 27-29, 2011 Session 6 Reactive Lymphoproliferations of the skin Rein Willemze Summary session 6 Atypical T-cell infiltrates (lymphomatoid; pseudo-t-cell lymphoma; PCSM-TCL). Atypical B-cell infiltrates (CLH; pseudo-bcell lymphoma). Reactive conditions mimicking C-ALCL/LyP (Lupus) panniculitis Special cases Another four cases Session Summary Session 6 - case 211 Submitted by Gulsah Kaygusuz and Isinsu Kuzu Ankara University, School of Medicine, Dept. of Pathology, Turkey 21 years old, female presented with subcutaneous, nodular lesion on right temporal region of the scalp for 2 months. H&E CD20 CD3 Bcl-6 H&E Bcl-2 CD21 Ki-67 1

2 Session 6 - case 211 Submitted by Gulsah Kaygusuz and Isinsu Kuzu Ankara University, School of Medicine, Dept. of Pathology, Turkey Reactive follicular hyperplasia due to bloodsucker (Annelida, Hirudinea) application. Multiple pseudolymphomas caused by Hirudo medicinalis therapy Smolle J. et al. J Am Acad Dermatol 43,867,2000 Cutaneous Lymphoid hyperplasia Etiology: Tick bites (Borrelia burgdorferi infection) Tattoo pigments Antigen injections; piercings; golden earrings, etc. Unknown In common: intradermal antigens bypassing epidermal LC network. Multiple pseudolymphomas caused by Hirudo medicinalis therapy Smolle J. et al. J Am Acad Dermatol 43,867,2000 Synonyms: Pseudo-B-cell lymphoma Lymphadenosis benigna cutis Lymphocytoma cutis Sarcoid of Spiegler-Fendt CLH tick bite - tattoo Session 6 - case 91 Submitted by Erick Jacobson-Dunlop, MD et al. Depts. of Dermatology and Pathology, Oregon Health and Science University as Scabies Bite Reaction Mimicking LyP A 51-year-old woman presenting with a two month history of pruritic lesions on her arms and trunk. 2

3 Session 6 - case 91 Submitted by Erick Jacobson-Dunlop, MD et al. CD3 Depts. of Dermatology and Pathology, Oregon Health and Science University CD2 0 Scabies Bite Reaction CD4 CD8 CD30 L U M C Benign cutaneous CD30+ conditions Viral infection: molluscum contagiosum Orf; milker s nodule Herpes virus infection HPV HIV Parasite infections (scabies) Atopic dermatitis Insect bites, patch tests, etc. Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE). Session 6 - case 303 Submitted by Patty Jansen and Rein Willemze Depts. of Pathology and Dermatology, LUMC, Leiden, The Netherlands Clinical History: 21-year-old female with an ulcerative lesion on mucosa upper lip since one week. 3

4 CD3 CD4 CD8 CD3 CD4 CD8 CD5 CD5 CD30 Ki-67 CD68 CD30 TIA-1 Ki-67 Case 303 main findings Ulcerative lesion of oral mucosa. Atypical T-cell infiltrate of medium-sized to large blast cells, admixed with small lymphocytes, histiocytes and eosinophils. Phenotype: CD30+/-, CD2+, CD3+, CD4+, CD5-, CD8-, CD56-, TIA-1+, GrB-. EBER: negative Clonal TCR gene rearrangement. Staging negative. Case 303 main findings Differential diagnosis: Counterpart spectrum cutaneous CD30+ LPD TUGSE 4

5 Session 6 - case 303 Case 303 TUGSE Submitted by Patty Jansen and Rein Willemze Depts. of Pathology and Dermatology, LUMC, Leiden, The Netherlands Traumatic Ulcerative Granuloma with Stromal Eosinophilia of the oral cavity (TUGSE) Ulcerative lesion of oral mucosa (tongue). Self-limiting; rapid regression (after biopsy). DD clinically: SCC; lymphoma; syphilis!! CD30+ large atypical cells (50%) Stromal eosinophilia May be clonal (25%) Session 6 - case 159 Submitted by Seble Chekol, MD and Nahid Nanaji MD Dept. of Pathology, University of Maryland Medical Center, Baltimore as Cutaneous anaplastic large cell lymphoma (ALK negative) 83-year-old female with an ulcerative lesion on her lower lip. Previously biopsied and diagnosed as poorly differentiated SCC. Examination: exophytic mass on the lower lip. 5

6 Session 6 - case 159 CD45 CD3 Submitted by Seble Chekol, MD and Nahid Nanaji MD Dept. of Pathology, University of Maryland Medical Center, Baltimore CD30 ALK Traumatic Ulcerative Granuloma with Stromal Eosinophilia of the oral cavity (TUGSE) 6

SH/EAHP Workshop 2011 Los Angeles, California, USA

SH/EAHP Workshop 2011 Los Angeles, California, USA SH/EAHP Workshop 2011 Los Angeles, California, USA October 27-29, 2011 Session 3 Non-Mycosis Fungoides CTCL Patty Jansen & Rein Willemze Introduction Submitted: 101 cases + 7 cases group 1: 108 Deactivated

More information

Primary Cutaneous CD30-Positive T-cell Lymphoproliferative Disorders

Primary Cutaneous CD30-Positive T-cell Lymphoproliferative Disorders Primary Cutaneous CD30-Positive T-cell Lymphoproliferative Disorders Definition A spectrum of related conditions originating from transformed or activated CD30-positive T-lymphocytes May coexist in individual

More information

Important Decisions in Dermatopathology: The Clinico- Pathologic Correlation. Dermatopathology Specialists Needed. Changing Trends

Important Decisions in Dermatopathology: The Clinico- Pathologic Correlation. Dermatopathology Specialists Needed. Changing Trends Important Decisions in Dermatopathology: The Clinico- Pathologic Correlation Uma Sundram, MD, PhD Departments of Pathology and Dermatology Stanford University May 29, 2008 Dermatopathology Specialists

More information

Lymphoma and Pseudolymphoma

Lymphoma and Pseudolymphoma Lymphoma and Pseudolymphoma Laura B. Pincus, MD Co-Director, Cutaneous Lymphoma Clinic Associate Professor Dermatology and Pathology University of California, San Francisco I HAVE NO RELEVANT RELATIONSHIPS

More information

1/14/2018. Objectives

1/14/2018. Objectives 2018 Pathology CME Cutaneous Hematopathology Maui, HI Jan 18 th 26 th Pseudolymphomas Alejandro A. Gru, M.D. Assistant Professor of Pathology & Dermatology Dermatopathology Division and Fellowship Director

More information

Review Article. Cutaneous lymphoproliferative disorders. NJ Trendell-Smith

Review Article. Cutaneous lymphoproliferative disorders. NJ Trendell-Smith Hong Kong J. Dermatol. Venereol. (2010) 18, 190-201 Review Article Cutaneous lymphoproliferative disorders NJ Trendell-Smith Cutaneous lymphoproliferative disorders (CLD) include reactive lymphoid hyperplasias,

More information

Primer of Immunohistochemistry (Leukocytic)

Primer of Immunohistochemistry (Leukocytic) Primer of Immunohistochemistry (Leukocytic) Paul K. Shitabata, M.D. Dermatopathology Institute Torrance, CA BENIGN LYMPHOID SKIN LESIONS CAPABLE OF SIMULATING LYMPHOMA -Jessner s lymphoid infiltrate -Dermal-subcutaneous

More information

New Haven, Connecticut

New Haven, Connecticut New Haven, Connecticut Yale University Main Campus Yale mascot: Handsome Dan Cutaneous Lymphomas Tony Subtil, MD, MBA Associate Professor Yale University Cutaneous Lymphomas: 1. Intro 2. CTCL/NK 3. CBCL

More information

Unusual cutaneous presentation of a T-cell lymphoproliferation

Unusual cutaneous presentation of a T-cell lymphoproliferation Department of Pathology and Cytology University Hospital Centre Zagreb, Croatia Unusual cutaneous presentation of a T-cell lymphoproliferation Snjezana Dotlic, Stefan Dojcinov, Leticia Quintanilla-Fend

More information

Classification of Cutaneous T cell Lymphomas (CTCLs) Hernani Cualing, MD

Classification of Cutaneous T cell Lymphomas (CTCLs) Hernani Cualing, MD Classification of Cutaneous T cell Lymphomas (CTCLs) Hernani Cualing, MD Pathology and Cell Biology, USF IFLOW, Inc. CTCL, MF, and Sézary syndrome In 1806, mycosis fungoides (MF) was first described 1

More information

Cutaneous Lymphoid Proliferations: A Comprehensive Textbook of Lymphocytic Infiltrates of the Skin

Cutaneous Lymphoid Proliferations: A Comprehensive Textbook of Lymphocytic Infiltrates of the Skin Cutaneous Lymphoid Proliferations: A Comprehensive Textbook of Lymphocytic Infiltrates of the Skin Magro, Cynthia M., MD ISBN-13: 9780471695981 Table of Contents Chapter One: Introduction to the Classification

More information

Traumatic Ulcerative Granuloma With Stromal Eosinophilia A Reactive Lesion of the Oral Mucosa

Traumatic Ulcerative Granuloma With Stromal Eosinophilia A Reactive Lesion of the Oral Mucosa Hematopathology / TRAUMATIC ULCERATIVE GRANULOMA Traumatic Ulcerative Granuloma With Stromal Eosinophilia A Reactive Lesion of the Oral Mucosa Abraham Hirshberg, MD, DMD, 1 Ninette Amariglio, PhD, 2 Sharon

More information

CASE REPORT. Mineui Hong Young Hyeh Ko 1

CASE REPORT. Mineui Hong Young Hyeh Ko 1 Journal of Pathology and Translational Medicine 2015; 49: 525-530 CASE STUDY CD30-Positive T-Cell Lymphoproliferative Disease of the Oral Mucosa in Children: A Manifestation of Epstein-Barr Virus-Associated

More information

Lymphocytoma Cutis. Cynthia M. Magro MD. Director of Dermatopathology Weill Medical College of Cornell University New York, New York

Lymphocytoma Cutis. Cynthia M. Magro MD. Director of Dermatopathology Weill Medical College of Cornell University New York, New York Lymphocytoma Cutis Cynthia M. Magro MD Professor of Pathology Director of Dermatopathology Weill Medical College of Cornell University New York, New York Lymphocytoma Cutis Falls under other designations

More information

A middle-aged man with self-healing papulonecrotic lesions over the trunk and proximal limbs

A middle-aged man with self-healing papulonecrotic lesions over the trunk and proximal limbs Hong Kong J. Dermatol. Venereol. (2011) 19, 30-34 Case Report A middle-aged man with self-healing papulonecrotic lesions over the trunk and proximal limbs JC Chan, N Trendell-Smith, CK Yeung Lymphomatoid

More information

Int J Clin Exp Pathol 2015;8(9): /ISSN: /IJCEP

Int J Clin Exp Pathol 2015;8(9): /ISSN: /IJCEP Int J Clin Exp Pathol 2015;8(9):11685-11690 www.ijcep.com /ISSN:1936-2625/IJCEP0012527 Case Report Primary mucosal CD30-positive T-cell lymphoproliferative disorders of the head and neck rarely involving

More information

Contents. vii. Preface... Acknowledgments... v xiii

Contents. vii. Preface... Acknowledgments... v xiii Contents Preface... Acknowledgments... v xiii SECTION I 1. Introduction... 3 Knowledge-Based Diagnosis... 4 Systematic Examination of the Lymph Node... 7 Cell Type Identification... 9 Cell Size and Cellularity...

More information

TOX expression in cutaneous B-cell lymphomas

TOX expression in cutaneous B-cell lymphomas Arch Dermatol Res (2016) 308:423 427 DOI 10.1007/s00403-016-1654-7 ORIGINAL PAPER TOX expression in cutaneous B-cell lymphomas Anne M. R. Schrader 1 Patty M. Jansen 1 Rein Willemze 2 Received: 20 January

More information

CME/SAM. Mimics of Cutaneous Lymphoma Report of the 2011 Society for Hematopathology/European Association for Haematopathology Workshop

CME/SAM. Mimics of Cutaneous Lymphoma Report of the 2011 Society for Hematopathology/European Association for Haematopathology Workshop Mimics of Cutaneous Lymphoma Report of the 2011 Society for Hematopathology/European Association for Haematopathology Workshop George P. Sarantopoulos, MD, 1 Beth Palla, MD, 1 Jonathan Said, MD, 1 Marsha

More information

ISPUB.COM. Management of Co-existing Mycosis Fungoides and Lymphomatoid Papulosis. E Kim PHYSICAL FINDINGS INTRODUCTION INITIAL PRESENTATION

ISPUB.COM. Management of Co-existing Mycosis Fungoides and Lymphomatoid Papulosis. E Kim PHYSICAL FINDINGS INTRODUCTION INITIAL PRESENTATION ISPUB.COM The Internet Journal of Dermatology Volume 7 Number 3 Management of Co-existing Mycosis Fungoides and Lymphomatoid Papulosis E Kim Citation E Kim. Management of Co-existing Mycosis Fungoides

More information

ISPUB.COM. Primary Cutaneous Anaplastic Large Cell Lymphoma Long-term Management with Low Dose Methotrexate. S Parker INTRODUCTION

ISPUB.COM. Primary Cutaneous Anaplastic Large Cell Lymphoma Long-term Management with Low Dose Methotrexate. S Parker INTRODUCTION ISPUB.COM The Internet Journal of Dermatology Volume 7 Number 3 Primary Cutaneous Anaplastic Large Cell Lymphoma Long-term Management with Low Dose S Parker Citation S Parker.. The Internet Journal of

More information

Hepatic Lymphoma Diagnosis An Algorithmic Approach

Hepatic Lymphoma Diagnosis An Algorithmic Approach Hepatic Lymphoma Diagnosis An Algorithmic Approach Ryan M. Gill, M.D., Ph.D. University of California, San Francisco PLEASE TURN OFF YOUR CELL PHONES Disclosure of Relevant Financial Relationships USCAP

More information

BSD Self Assessment Workshop 7 th July 2013 CASE 27 RAC6123

BSD Self Assessment Workshop 7 th July 2013 CASE 27 RAC6123 BSD Self Assessment Workshop 7 th July 2013 CASE 27 RAC6123 M55. 4/7 tender lesions on knee, legs and arms. Also iritis/ weight loss/headache, synovitis.?vasculitis. Sarcoidosis. Biopsy from left elbow

More information

Overview of Cutaneous Lymphomas: Diagnosis and Staging. Lauren C. Pinter-Brown MD, FACP Health Sciences Professor of Medicine and Dermatology

Overview of Cutaneous Lymphomas: Diagnosis and Staging. Lauren C. Pinter-Brown MD, FACP Health Sciences Professor of Medicine and Dermatology Overview of Cutaneous Lymphomas: Diagnosis and Staging Lauren C. Pinter-Brown MD, FACP Health Sciences Professor of Medicine and Dermatology Definition of Lymphoma A cancer or malignancy that comes from

More information

Disclosures. Advisory Board. Consultant. Investigator. MiRagen, Actelion, Celgene, Therakos. Mindera

Disclosures. Advisory Board. Consultant. Investigator. MiRagen, Actelion, Celgene, Therakos. Mindera Cutaneous Lymphomas Christiane Querfeld, MD, PhD Director, Cutaneous Lymphoma Program City of Hope ~ How the Experts Treat Hematologic Malignancies Symposium March 10 13, 2017 Disclosures Advisory Board

More information

Egyptian Dermatology Online Journal Vol. 6 No 1: 14, June 2010

Egyptian Dermatology Online Journal Vol. 6 No 1: 14, June 2010 Wells Syndrome H. Gammaz, H. Amer, A. Adly and S. Mahmoud Egyptian Dermatology Online Journal 6 (1): 14 Al-Haud Al-Marsoud Hospital, Cairo, Egypt e-mail: hananderma@hotmail.com Submitted: April 15, 2010

More information

CD30+ Lymphoproliferative Disorders Associated with Longstanding Mycosis Fungoides

CD30+ Lymphoproliferative Disorders Associated with Longstanding Mycosis Fungoides Case Report DOI: 10.6003/jtad.16102c5 CD30+ Lymphoproliferative Disorders Associated with Longstanding Mycosis Fungoides Esra Adışen, 1 MD, Özlem Erdem, 2 MD, Mehmet Ali Gürer, 1 MD Address: 1 Gazi University

More information

Viral Infections. Chicken Pox 5/21/2018

Viral Infections. Chicken Pox 5/21/2018 Napa Valley Dermatopathology Meeting 2018 - Select Infections & Infestations Whitney A. High, MD, JD, MEng whitney.high@ucdenver.edu Professor of Dermatology & Pathology Vice-Chairman, Dermatology Director

More information

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle   holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/2010 holds various files of this Leiden University dissertation. Author: Benner, Marchina Frederika Title: Cutaneous CD30-positive lymphoproliferations

More information

T cell lymphoma diagnostics and differential diagnosis to Hodgkin lymphoma

T cell lymphoma diagnostics and differential diagnosis to Hodgkin lymphoma T cell lymphoma diagnostics and differential diagnosis to Hodgkin lymphoma Sylvia Hartmann Dr. Senckenberg Institute of Pathology Goethe University Frankfurt Overview Borderline ALCL classical HL Borderline

More information

CD30-Positive Atypical Lymphoid Cells in Common Non-Neoplastic Cutaneous Infiltrates Rich in Neutrophils and Eosinophils

CD30-Positive Atypical Lymphoid Cells in Common Non-Neoplastic Cutaneous Infiltrates Rich in Neutrophils and Eosinophils -----Original Message----- From: Rob Howes [mailto:robhowes@cox.net] Sent: Thursday, 17 March 2005 11:05 PM To: Rob Howes Subject: 2003 CD30-Positive Atypical Lymphoid Cells in Common Non-Neoplastic Cutaneous

More information

Immunocytochemistry and the diagnosis of cutaneous lymphoma

Immunocytochemistry and the diagnosis of cutaneous lymphoma Histopathology 2010, 56, 71 90. DOI: 10.1111/j.1365-2559.2009.03457.x REVIEW Immunocytochemistry and the diagnosis of cutaneous lymphoma Alistair Robson Department of Dermatopathology, St John s Institute

More information

Methotrexate-associated Lymphoproliferative Disorders

Methotrexate-associated Lymphoproliferative Disorders Methotrexate-associated Lymphoproliferative Disorders Definition A lymphoid proliferation or lymphoma in a patient immunosuppressed with methotrexate, typically for treatment of autoimmune disease (rheumatoid

More information

Monoclonal B-cell Lymphocytosis

Monoclonal B-cell Lymphocytosis Entity Centred Approach Lymphoma Classification: WHO and Beyond Clinically meaningful categories Dr Stefan Dojcinov University Hospital of Wales, Cardiff WHO UPDATE - NEW ENTITIES Early lesions lymphoma

More information

FOLLICULARITY in LYMPHOMA

FOLLICULARITY in LYMPHOMA FOLLICULARITY in LYMPHOMA Reactive Follicular Hyperplasia Follicular Hyperplasia irregular follicles Follicular Hyperplasia dark and light zones Light Zone Dark Zone Follicular hyperplasia MIB1 Follicular

More information

CASE year old male with a PET avid nodule in the left adrenal gland

CASE year old male with a PET avid nodule in the left adrenal gland CASE 1 55 year old male with a PET avid nodule in the left adrenal gland Case 1 Adrenal gland parenchyma partly replaced by a spindle cell tumour with mild nuclear pleomorphism Atypical mitoses present

More information

Evening specialty conference: Liver

Evening specialty conference: Liver Evening specialty conference: Liver Joseph Misdraji, M.D. Disclosure of Relevant Financial Relationships Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee)

More information

Case Report A Severe Case of Lymphomatoid Papulosis Type E Successfully Treated with Interferon-Alfa 2a

Case Report A Severe Case of Lymphomatoid Papulosis Type E Successfully Treated with Interferon-Alfa 2a Hindawi Case Reports in Dermatological Medicine Volume 2017, Article ID 3194738, 5 pages https://doi.org/10.1155/2017/3194738 Case Report A Severe Case of Lymphomatoid Papulosis Type E Successfully Treated

More information

Mimics of Lymphoma in Routine Biopsies. I have nothing to disclose regarding the information to be reported in this talk.

Mimics of Lymphoma in Routine Biopsies. I have nothing to disclose regarding the information to be reported in this talk. Mimics of Lymphoma in Routine Biopsies Patrick Treseler, MD, PhD Professor of Pathology University of California San Francisco I have nothing to disclose regarding the information to be reported in this

More information

Primary cutaneous large cell lymphoma CD30+: a case-based review

Primary cutaneous large cell lymphoma CD30+: a case-based review Case-based review Primary cutaneous large cell lymphoma CD30+: a case-based review Anna Campanati 1 Katia Giuliodori 1 Emanuela Martina 1 Luca Conocchiari 1 Giulia Ganzetti 1 Gaia Goteri 2 Annamaria Offidani

More information

Michi Shinohara MD Associate Professor University of Washington/Seattle Cancer Care Alliance Dermatology, Dermatopathology

Michi Shinohara MD Associate Professor University of Washington/Seattle Cancer Care Alliance Dermatology, Dermatopathology Michi Shinohara MD Associate Professor University of Washington/Seattle Cancer Care Alliance Dermatology, Dermatopathology Agenda Overview of cutaneous T and B- cell lymphomas Diagnosis, Staging, Prognosis

More information

Non-Hodgkin s Lymphomas Version

Non-Hodgkin s Lymphomas Version NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines ) Non-Hodgkin s Lymphomas Version 2.2015 NCCN.org Continue Use of Immunophenotyping/ Genetic Testing in Differential Diagnosis of Mature B-Cell

More information

Malignant Lymphomas Decision Making and Problem Solving

Malignant Lymphomas Decision Making and Problem Solving Malignant Lymphomas Decision Making and Problem Solving Cutaneous T-cell lymphomas (including rare subtypes). Current concepts. II. [haematologica] 2004;89:1372-1388 MARCO PAULLI EMILIO BERTI A B S T R

More information

Mimics of Lymphoma in Routine Biopsies. Mixed follicular and paracortical hyperplasia. Types of Lymphoid Hyperplasia

Mimics of Lymphoma in Routine Biopsies. Mixed follicular and paracortical hyperplasia. Types of Lymphoid Hyperplasia Mimics of Lymphoma in Routine Biopsies Patrick Treseler, MD, PhD Professor of Pathology University of California San Francisco Types of Lymphoid Hyperplasia Follicular hyperplasia (B-cells) Paracortical

More information

CPC. Chutika Srisuttiyakorn, M.D. Kobkul Aunhachoke, M.D. Phramongkutklao Hospital Bangkok, Thailand

CPC. Chutika Srisuttiyakorn, M.D. Kobkul Aunhachoke, M.D. Phramongkutklao Hospital Bangkok, Thailand CPC Chutika Srisuttiyakorn, M.D. Kobkul Aunhachoke, M.D. Phramongkutklao Hospital Bangkok, Thailand A 53 year-old woman with fever, facial swelling and rashes on face, trunk and upper extremities for 3

More information

Granuloma annulare is a benign self-limited disease, first described by Colcott-Fox 1 in 1895 and Radcliffe-Crocker in 1902.

Granuloma annulare is a benign self-limited disease, first described by Colcott-Fox 1 in 1895 and Radcliffe-Crocker in 1902. Granuloma Annulare Granuloma annulare is a benign self-limited disease, first described by Colcott-Fox 1 in 1895 and Radcliffe-Crocker in 1902. EPIDEMIOLOGY Granuloma annulare is a relatively common disorder.

More information

Lymphomatoid Papulosis 3 Case Reports

Lymphomatoid Papulosis 3 Case Reports IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-issn: 2279-0853, p-issn: 2279-0861.Volume 14, Issue 7 Ver. III (July. 2015), PP 31-35 www.iosrjournals.org Lymphomatoid Papulosis 3 Case Reports

More information

Radiotherapy in aggressive cutaneous pseudolymphoma: a case report and review of literature

Radiotherapy in aggressive cutaneous pseudolymphoma: a case report and review of literature Case Report Radiat Oncol J 2016;34(1):76-80 pissn 2234-1900 eissn 2234-3156 Radiotherapy in aggressive cutaneous pseudolymphoma: a case report and review of literature Deepa Joseph, MD, Monica Malik Irukulla,

More information

Angiolymphoid Hyperplasia with Eosinophilia. Spencer Rusin M4, CUMC Deba P Sarma, MD Omaha

Angiolymphoid Hyperplasia with Eosinophilia. Spencer Rusin M4, CUMC Deba P Sarma, MD Omaha Angiolymphoid Hyperplasia with Eosinophilia Spencer Rusin M4, CUMC Deba P Sarma, MD Omaha Patient Presentation F 55, presents with a 10-month history of : Non-ulcerated, painless nodule (0.5 cm) on her

More information

10/31/2017. Immunodeficiencies. Outline. Discuss EBV. Non-destructive Polymorphic Monomorphic Therapies Challenges

10/31/2017. Immunodeficiencies. Outline. Discuss EBV. Non-destructive Polymorphic Monomorphic Therapies Challenges I have no financial disclosures Joo Y. Song, MD Assistant Professor of Clinical Pathology City of Hope National Medical Center Immunodeficiencies Outline Transplant Congenital Autoimmunity T-cell/immune

More information

11/2/2017. Immunodeficiencies. Joo Y. Song, MD Assistant Professor of Clinical Pathology. I have no financial disclosures.

11/2/2017. Immunodeficiencies. Joo Y. Song, MD Assistant Professor of Clinical Pathology. I have no financial disclosures. I have no financial disclosures Joo Y. Song, MD Assistant Professor of Clinical Pathology City of Hope National Medical Center Immunodeficiencies Transplant Autoimmunity Drugs T-cell dysfunction (Age,

More information

CASE 15 Patient: A 41-year-old Thai female Chief Compliant: Generalized papulovesicular rash for 1 month Present Illness: She presented with a 1-week

CASE 15 Patient: A 41-year-old Thai female Chief Compliant: Generalized papulovesicular rash for 1 month Present Illness: She presented with a 1-week CASE 15 Patient: A 41-year-old Thai female Chief Compliant: Generalized papulovesicular rash for 1 month Present Illness: She presented with a 1-week history of the generalized asymptomatic erythematous

More information

Granulomatous Slack Skin with an unusually aggressive course due to the subsequent development of a CD30-positive Large Cell Lymphoma

Granulomatous Slack Skin with an unusually aggressive course due to the subsequent development of a CD30-positive Large Cell Lymphoma Granulomatous Slack Skin with an unusually aggressive course due to the subsequent development of a CD30-positive Large Cell Lymphoma Alexandra Papoudou-Bai 1, Eleni Kapsali 2, Ioannis Kostas-Agnantis

More information

Contents. Part I Genodermatoses

Contents. Part I Genodermatoses Contents Part I Genodermatoses 1 Hyperkeratotic Palms and Soles with Periorificial Keratosis............... 3 2 Indurated, Dark, Hairy Plaques, with Arthritis and Deafness.............. 9 3 Cleft Palate,

More information

Common Problem Areas. WHO Classification. Defines separate diseases (entities) with their CLINICAL AGGRESSIVENESS LOW GRADE / HIGH GRADE

Common Problem Areas. WHO Classification. Defines separate diseases (entities) with their CLINICAL AGGRESSIVENESS LOW GRADE / HIGH GRADE WHO Classification Defines separate diseases (entities) with their CLINICAL AGGRESSIVENESS REVIEW OF MOST COMMON LYMPHOMA ENTITIES Dr Stefan Dojcinov LOW GRADE / HIGH GRADE (June 2014) The Non-Hodgkin

More information

Maligna Melanoma and Atypical Fibroxanthoma: An Unusual Collision Tumour G Türkcü 1, A Keleş 1, U Alabalık 1, D Uçmak 2, H Büyükbayram 1 ABSTRACT

Maligna Melanoma and Atypical Fibroxanthoma: An Unusual Collision Tumour G Türkcü 1, A Keleş 1, U Alabalık 1, D Uçmak 2, H Büyükbayram 1 ABSTRACT Maligna Melanoma and Atypical Fibroxanthoma: An Unusual Collision Tumour G Türkcü 1, A Keleş 1, U Alabalık 1, D Uçmak 2, H Büyükbayram 1 ABSTRACT Two different neoplasia in the same biopsy material called

More information

Pearls and pitfalls in interpretation of lymphoid lesions in needle biopsies

Pearls and pitfalls in interpretation of lymphoid lesions in needle biopsies Pearls and pitfalls in interpretation of lymphoid lesions in needle biopsies Megan S. Lim MD PhD University of Pennsylvania October 8, 2018 Objectives To understand how the trend toward less invasive lymph

More information

21/07/2017. Lymphoproliferations in immunodeficiency. IBD and EBV associated LPD in GIT Han van Krieken. Inflammatory bowel disease and cancer

21/07/2017. Lymphoproliferations in immunodeficiency. IBD and EBV associated LPD in GIT Han van Krieken. Inflammatory bowel disease and cancer IBD and EBV associated LPD in GIT Han van Krieken Lymphoproliferations in immunodeficiency Primary immunodeficiencies Large variation in conditions and lesions Acquired immunodeficiencies HIV: changes

More information

2. Sézary syndrome (SS)

2. Sézary syndrome (SS) Go Back to the Top To Order, Visit the Purchasing Page for Details Clinical images are available in hardcopy only. Clinical images are available in Clinical images are available in d e f g h i j Fig..36-2

More information

PRELIMINARY AND SHORT REPORTS

PRELIMINARY AND SHORT REPORTS PRELIMINARY AND SHORT REPORTS TICKBITE GRANULOMA* NORMAN TOBIA5, M.D. Tick bites are not uncommon, but in rare cases, persistent nodular lesions result which may cause confusion from a clinical and pathological

More information

Proceedings of the 36th World Small Animal Veterinary Congress WSAVA

Proceedings of the 36th World Small Animal Veterinary Congress WSAVA www.ivis.org Proceedings of the 36th World Small Animal Veterinary Congress WSAVA Oct. 14-17, 2011 Jeju, Korea Next Congress: Reprinted in IVIS with the permission of WSAVA http://www.ivis.org 14(Fri)

More information

Skin lesions The Good and the Bad. Dr Virginia Hubbard Ipswich Hospital NHS Trust Barts and the London School of Medicine and Dentistry

Skin lesions The Good and the Bad. Dr Virginia Hubbard Ipswich Hospital NHS Trust Barts and the London School of Medicine and Dentistry Skin lesions The Good and the Bad Dr Virginia Hubbard Ipswich Hospital NHS Trust Barts and the London School of Medicine and Dentistry Case 1 32 year old woman Australian Lesion on back New hair growing

More information

Didactic Series. HIV related Dermatologic Manifestations. Ankita Kadakia, MD UC San Diego, Owen Clinic April 26, 2018

Didactic Series. HIV related Dermatologic Manifestations. Ankita Kadakia, MD UC San Diego, Owen Clinic April 26, 2018 Didactic Series HIV related Dermatologic Manifestations Ankita Kadakia, MD UC San Diego, Owen Clinic April 26, 2018 1 Learning Objectives 1) Recognize common dermatologic manifestations associated with

More information

Angioinvasive Lymphomatoid Papulosis: A new variant simulating aggressive lymphomas

Angioinvasive Lymphomatoid Papulosis: A new variant simulating aggressive lymphomas Zurich Open Repository and Archive University of Zurich Main Library Strickhofstrasse 39 CH-8057 Zurich www.zora.uzh.ch Year: 2013 Angioinvasive Lymphomatoid Papulosis: A new variant simulating aggressive

More information

Key words: diagnosis, immunoglobulin G4, immunoglobulin G4-related diseases, immunohistochemistry, pseudolymphoma. CASE HISTORY

Key words: diagnosis, immunoglobulin G4, immunoglobulin G4-related diseases, immunohistochemistry, pseudolymphoma. CASE HISTORY doi: 10.1111/1346-8138.12301 Journal of Dermatology 2013; 40: 998 1003 ORIGINAL ARTICLE Case of immunoglobulin G4-related skin disease: Possible immunoglobulin G4-related skin disease cases in cutaneous

More information

Didactic Series. Dermatologic Manifestations Associated with HIV/AIDS. Ankita Kadakia, MD UCSD Owen Clinic 12/11/2014

Didactic Series. Dermatologic Manifestations Associated with HIV/AIDS. Ankita Kadakia, MD UCSD Owen Clinic 12/11/2014 Didactic Series Dermatologic Manifestations Associated with HIV/AIDS Ankita Kadakia, MD UCSD Owen Clinic 12/11/2014 ACCREDITATION STATEMENT: University of California, San Diego School of Medicine is accredited

More information

MUCOCUTANEOUS MANIFESTATIONS OF HIV/AIDS IN ADOLESCENTS

MUCOCUTANEOUS MANIFESTATIONS OF HIV/AIDS IN ADOLESCENTS MUCOCUTANEOUS MANIFESTATIONS OF HIV/AIDS IN ADOLESCENTS Dr. Y.S.MARFATIA Prof. and Head, Dept. Skin & V.D. Medical college, Vadodara LET US CREATE BRILLIANCE TOGETHER MEDICAL COLLEGE, VADODARA Editor in

More information

Basal cell carcinoma 5/28/2011

Basal cell carcinoma 5/28/2011 Goal of this Presentation A practical approach to the diagnosis of cutaneous carcinomas and their mimics Thaddeus Mully, MD University of California San Francisco To review common non-melanoma skin cancers

More information

Feline cutaneous lymphocytosis: case report and summary of the literature

Feline cutaneous lymphocytosis: case report and summary of the literature Journal of Feline Medicine and Surgery (2014) 16, 758 763 C A S E R E P O R T Feline cutaneous lymphocytosis: case report and summary of the literature Marlene S Pariser DVM 1 Dunbar W Gram DVM MRCVS DipACVD

More information

Incidence. Bimodal age incidence 15-40, >55 years Childhood form (0-14) more common in developing countries M:F=1.5:1; in all subtypes except NS

Incidence. Bimodal age incidence 15-40, >55 years Childhood form (0-14) more common in developing countries M:F=1.5:1; in all subtypes except NS Hodgkin Lymphoma Hodgkin Lymphoma 30% of all lymphomas Absolute incidence unchanged Arise in lymph node, cervical region Neoplastic tissues usually contain a small number of tumor cells Incidence Bimodal

More information

CONDITIONS OF THE SKIN

CONDITIONS OF THE SKIN CONDITIONS OF THE SKIN UCSF/SFGH Family & Community Medicine Residency Program Educational Objectives I. Knowledge The resident will be able to discuss the definition, diagnosis, and initial management

More information

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/39089 holds various files of this Leiden University dissertation. Author: Cetinozman, F. Title: PD-1 Expression in primary cutaneous lymphoma Issue Date:

More information

المركب النموذج--- سبيتز وحمة = Type Spitz's Nevus, Compound SPITZ NEVUS 1 / 7

المركب النموذج--- سبيتز وحمة = Type Spitz's Nevus, Compound SPITZ NEVUS 1 / 7 SPITZ NEVUS 1 / 7 Epidemiology An annual incidence rate of 1.4 cases of Spitz nevus per 100,000 individuals has been estimated in Australia, compared with 25.4 per 100,000 individuals for cutaneous melanoma

More information

88-year-old Female with Lymphadenopathy. Faizi Ali, MD

88-year-old Female with Lymphadenopathy. Faizi Ali, MD 88-year-old Female with Lymphadenopathy Faizi Ali, MD Clinical History A 88-year-old caucasian female presented to our hospital with the complaints of nausea, vomiting,diarrhea, shortness of breath and

More information

Cover Page. The handle holds various files of this Leiden University dissertation.

Cover Page. The handle  holds various files of this Leiden University dissertation. Cover Page The handle http://hdl.handle.net/1887/39089 holds various files of this Leiden University dissertation. Author: Cetinozman, F. Title: PD-1 Expression in primary cutaneous lymphoma Issue Date:

More information

2016 AAD SUMMER MEETING SYMPOSIUM S011: CLINICOPATHOLOGIC SELF-ASSESSMENT 7/30/16 2:00 PM. Tom Helm, MD

2016 AAD SUMMER MEETING SYMPOSIUM S011: CLINICOPATHOLOGIC SELF-ASSESSMENT 7/30/16 2:00 PM. Tom Helm, MD 2016 AAD SUMMER MEETING SYMPOSIUM S011: CLINICOPATHOLOGIC SELF-ASSESSMENT 7/30/16 2:00 PM Tom Helm, MD Case 1 Diagnosis: Pseudoepitheliomatous hyperplasia associated with CD30+ lymphoproliferative disease

More information

CASE 35 CLINICAL HISTORY

CASE 35 CLINICAL HISTORY Female, 24 Painful ulcerated lesion Left buttock Developed over a few weeks?abscess Excision CASE 35 CLINICAL HISTORY Two months later developed a similar lesion on right buttock CD30 CD3 CD4

More information

A 40-year old male with follicular papule and pustule at central face area for 3 months

A 40-year old male with follicular papule and pustule at central face area for 3 months A 40-year old male with follicular papule and pustule at central face area for 3 months GMS- Neg AFB-Neg Fite stain - neg HISTOPATHOLOGICAL DIFFERENTIAL DIAGNOSIS CASEOUS GRANULOMA INFECTION -MYCOBACTERIUM

More information

Common Benign Lesions and Skin Cancers. 22nd May 2015 Dr Mark Foley

Common Benign Lesions and Skin Cancers. 22nd May 2015 Dr Mark Foley Common Benign Lesions and Skin Cancers 22nd May 2015 Dr Mark Foley Thank you for downloading this file. This intended to supplement the presentation given at the NZ Wound Care Conference, it is not intended

More information

Follicular lymphomatoid papulosis revisited: a study of 11 cases, with new histopathological findings

Follicular lymphomatoid papulosis revisited: a study of 11 cases, with new histopathological findings Zurich Open Repository and Archive University of Zurich Main Library Strickhofstrasse 39 CH-8057 Zurich www.zora.uzh.ch Year: 2013 Follicular lymphomatoid papulosis revisited: a study of 11 cases, with

More information

Second Joint Conference 0f the British HIV Association [BHIVA] and the British Association for Sexual Health and HIV [BASHH]

Second Joint Conference 0f the British HIV Association [BHIVA] and the British Association for Sexual Health and HIV [BASHH] Second Joint Conference 0f the British HIV Association [BHIVA] and the British Association for Sexual Health and HIV [BASHH] 20-23 April 2010, Manchester Central Convention Complex SECOND JOINT CONFERENCE

More information

Use of PD-1, CD1a, and S-100 in Differentiating Pseudolymphomatous Folliculitis and Indolent Primary Cutaneous B-Cell Lymphomas

Use of PD-1, CD1a, and S-100 in Differentiating Pseudolymphomatous Folliculitis and Indolent Primary Cutaneous B-Cell Lymphomas Use of PD-1, CD1a, and S-100 in Differentiating Pseudolymphomatous Folliculitis and Indolent Primary Cutaneous B-Cell Lymphomas The Harvard community has made this article openly available. Please share

More information

184 Cutaneous Lymphomas: Morphology, Immunohistochemistry and Molecular Testing. David Cassarino MD, PhD Aaron Auerbach MD

184 Cutaneous Lymphomas: Morphology, Immunohistochemistry and Molecular Testing. David Cassarino MD, PhD Aaron Auerbach MD 184 Cutaneous Lymphomas: Morphology, Immunohistochemistry and Molecular Testing David Cassarino MD, PhD Aaron Auerbach MD 2011 Annual Meeting Las Vegas, NV AMERICAN SOCIETY FOR CLINICAL PATHOLOGY 33 W.

More information

Modern Pathology (2012) 25, & 2012 USCAP, Inc. All rights reserved /12 $

Modern Pathology (2012) 25, & 2012 USCAP, Inc. All rights reserved /12 $ & 2012 USCAP, Inc. All rights reserved 0893-3952/12 $32.00 983 Mucosal CD30-positive T-cell lymphoproliferations of the head and neck show a clinicopathologic spectrum similar to cutaneous CD30-positive

More information

MOSTLY SEPTAL PANNICULITIS

MOSTLY SEPTAL PANNICULITIS Margot S. Peters, M.D. Professor of Dermatology and Laboratory Medicine & Pathology, Mayo Clinic PANNICULITIS C017 Essential Dermatopathology, What You Need to Know for Clinical Practice: Inflammatory.

More information

Study. Skin changes in internal malignancy

Study. Skin changes in internal malignancy Study Skin changes in internal malignancy R. Rajagopal, P. N. Arora $, C. V. Ramasastry*, P. K. Kar # Dept of Dermatology, 5 Air Force Hospital, C/o 99 APO, $ Former Prof & Head, Dept. of Dermatology,

More information

, , 2011 HODGKIN LYMPHOMA

, , 2011 HODGKIN LYMPHOMA European Federation of Cytology Societies 4tu Annual Tutorial in Cytopathology Trieste, June 6-10, 2011 HODGKIN LYMPHOMA Classification The World Health Organization Classification of Lymphomas (2001)

More information

South East England General Histopathology EQA Scheme

South East England General Histopathology EQA Scheme South East England General Histopathology EQA Scheme RWF-CP-EQA-TEM24 Revision 1.4 South East England General Histopathology EQA Scheme Round UU Final Case Analyses Document title: Case Consultation Presentation

More information

High Incidence of Gastrointestinal Tract Disorders and Autoimmunity in Primary Cutaneous Marginal Zone B-Cell Lymphomas

High Incidence of Gastrointestinal Tract Disorders and Autoimmunity in Primary Cutaneous Marginal Zone B-Cell Lymphomas Research Original Investigation High Incidence of Gastrointestinal Tract Disorders and Autoimmunity in Primary Cutaneous Marginal Zone B-Cell Lymphomas Joan Guitart, MD; Janyana Deonizio, MD; Tara Bloom,

More information

Rameshwar Gutte and Uday Khopkar

Rameshwar Gutte and Uday Khopkar Extragenital unilateral lichen sclerosus et atrophicus in a child: a case report Rameshwar Gutte and Uday Khopkar Department of Dermatolgy, Seth GSMC and KEM Hospital, Parel, Mumbai-400012, India Egyptian

More information

Combinations of morphology codes of haematological malignancies (HM) referring to the same tumour or to a potential transformation

Combinations of morphology codes of haematological malignancies (HM) referring to the same tumour or to a potential transformation Major subgroups according to the World Health Organisation (WHO) Classification Myeloproliferative neoplasms (MPN) Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or

More information

Case Report Transformation of a Cutaneous Follicle Center Lymphoma to a Diffuse Large B-Cell Lymphoma An Unusual Presentation

Case Report Transformation of a Cutaneous Follicle Center Lymphoma to a Diffuse Large B-Cell Lymphoma An Unusual Presentation Case Reports in Medicine Volume 21, Article ID 296523, 5 pages doi:1.1155/21/296523 Case Report Transformation of a Cutaneous Follicle Center Lymphoma to a Diffuse Large B-Cell Lymphoma An Unusual Presentation

More information

Supplementary Appendix

Supplementary Appendix Supplementary Appendix This appendix has been provided by the authors to give readers additional information about their work. Supplement to: Schuetz C, Huck K, Gudowius S, et al. An immunodeficiency disease

More information

U006 Primary Cutaneous Lymphomas: Diagnosis, Staging and When to Refer M. Yadira Hurley, MD

U006 Primary Cutaneous Lymphomas: Diagnosis, Staging and When to Refer M. Yadira Hurley, MD U006 Primary Cutaneous Lymphomas: Diagnosis, Staging and When to Refer M. Yadira Hurley, MD hurleyy@slu.edu DISCLOSURE OF RELATIONSHIPS WITH INDUSTRY Actelion: Speaker Honoraria, Investigator Grants, Consultant

More information

Non-Hodgkin Lymphoma. Protocol applies to non-hodgkin lymphoma involving any organ system except the gastrointestinal tract.

Non-Hodgkin Lymphoma. Protocol applies to non-hodgkin lymphoma involving any organ system except the gastrointestinal tract. Non-Hodgkin Lymphoma Protocol applies to non-hodgkin lymphoma involving any organ system except the gastrointestinal tract. Protocol revision date: January 2005 No AJCC/UICC staging system Procedures Cytology

More information

Mycosis Fungoides and Variants

Mycosis Fungoides and Variants Mycosis Fungoides and Variants Jennifer Madison McNiff, M.D. Associate Professor, Dermatology and Pathology Yale University School of Medicine Classic mycosis fungoides The most common cutaneous lymphoma

More information

STUDY. with a benign clinical course but a malignant appearance

STUDY. with a benign clinical course but a malignant appearance Lymphomatoid Papulosis STUDY Reappraisal of Clinicopathologic Presentation and Classification Into Subtypes A,, and C Laila El Shabrawi-Caelen, MD; Helmut Kerl, MD; Lorenzo Cerroni, MD Objectives: To analyze

More information

SH/EAHP Workshop 2011 Los Angeles, California, USA. October 27-29, Session 5. Other Lymphohistiocytic Malignancies of the Skin

SH/EAHP Workshop 2011 Los Angeles, California, USA. October 27-29, Session 5. Other Lymphohistiocytic Malignancies of the Skin SH/EAHP Workshop 2011 Los Angeles, California, USA October 27-29, 2011 Session 5 Other Lymphohistiocytic Malignancies of the Skin Dr. Patty Jansen Dr. Leticia Quintanilla-Fend Submitted cases session

More information

Peripheral T-cell lymphomas

Peripheral T-cell lymphomas XXXVI REUNIÓN ANUAL Peripheral T-cell lymphomas Dr. Antonio Martinez Hospital Clinic, University ofbarcelona antonmar@clinic.ub.es Madrid, February 8th, 2013 T-NHL vs B-NHL: the T-cell paradigm lambda

More information