Porokeratosis: Introduction
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- Agnes Underwood
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3 Porokeratosis: Introduction Benign epidermal proliferation Distinct clinical & histologic features 5 clinical subtypes Erroneously named porokeratosis
4 CLINICAL SUBTYPES 1. Porokeratosis of Mibelli 2. Disseminated Superficial (Actinic) Porokeratosis 3. Porokeratosis Palmaris Plantaris et Disseminata 4. Linear Porokeratosis 5. Punctate Porokeratosis
5 Pathogenesis Definitive pathogenesis unclear Disorder of keratinization (?) Hypotheses: 1. Mutant clone of keratinocytes with an inflammatory response Abnormal DNA ploidy in keratinocytes Immunocompromised hosts
6 Pathogenesis 2. Unidentified epidermal antigen with an inflammatory infiltrate directed against it Mediators released by the infiltrate provide mitotic stimulus for epidermal cells
7 POROKERATOSIS Exacerbating factors: Chemotherapy Ultraviolet radiation/puva Immunosuppression (AIDS, transplant) Chemical exposures/drugs benzylhydrochlorothiazide
8 POROKERATOSIS OF MIBELLI
9 Mibelli Epidemiology Begins in infancy/childhood Autosomal Dominant or sporadic Males > females
10 Porokeratosis of Mibelli Asymptomatic Localized & unilateral Grow slowly- up to 20cm Persists indefinitely
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12 Porokeratosis of Mibelli Lesions may occur anywhere acral locations are most common Nail Matrix: nail dystrophy Scalp lesions: alopecia Glans penis: erosive balanitis Buccal mucosa: macerated; scale appears as a milky white cord
13 Porokeratosis of Mibelli Bowen s Disease, SCC, and BCC all reported to develop from the lesions of porokeratosis Removal is recommended
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15 Disseminated Superficial Porokeratosis Multiple lesions with classic clinical and histopathologic appearance Bilateral and symmetric- loves the extremities 50% of cases are on sun exposed areas (i.e. the actinic variant)
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17 Disseminated Superficial Porokeratosis Immunosuppression = exacerbating factor Associations: AIDS Cirrhosis Crohn s Disease
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20 Epidemiology Disseminated Superficial (Actinic) Porokeratosis Most common variants Autosomal dominant Present in 3 rd - 4 th decades Female predilection
21 Asymptomatic or pruritic Distribution: DSAP DSP: trunk, genitals, palms, soles, mm DSAP: sun exposed sites, spares face! Slow growth Malignant degeneration may occur
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25 Linear Porokeratosis Rare Onset usually in infancy/childhood Inheritance pattern unclear Highest risk for malignant degeneration
26 Linear Porokeratosis Unilateral Segmental or generalized May follow Blaschko s lines Extremities, trunk, face May mimic linear epidermal nevus
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29 Porokeratosis Palmaris, Plantaris et Disseminata Starts on palms/soles May extend over entire body- can burn/sting Mucous membranesasymptomatic
30 Epidemiology Porokeratosis Palmaris Plantaris et Disseminata Rare Autosomal dominant Adolescence/early adulthood Men:women = 2:1
31 PPPD May exacerbate in summer months Malignant degeneration
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36 Punctate Porokeratosis Multiple minute, discreet, punctate, hyperkeratotic lesions surrounded by a thin, raised margin Palms & soles
37 Punctate Porokeratosis Epidemiology Adolescence/adulthood Concomitant involvement with other types Mibelli Linear
38 Differential Diagnosis Actinic Keratosis Stucco Keratoses Acrokeratosis Verruciformis Verruca plana Elastosis Perforans Serpiginosa CTCL
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40 Histology: Porokeratosis Cornoid lamella Dyskeratotic, pyknotic nuclei in kc Absent or decreased GL under CL Dermal inflammatory infiltrate Central epidermal atrophy variable +/- Malignant transformation
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42 Cornoid Lamella Localized area of faulty keratinization/disordered epithelial metabolism Arises in epidermis and may involve ostia of hair follicles or sweat ducts Also found incidentally in inflammatory, hyperplastic, and neoplastic disorders of the skin
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45 Treatment Options Cryotherapy Keratolytics Topical/Oral Retinoids Topical 5-FU Electrodessication Excision/Grafting Observation
46 Choice of Treatment Depends On: Size Location Function Aesthetics General health Clinical change
47 Natural History / Prognosis Lesions usually increase in size/number Progression pronounced in DSP and DSAP with UV exposure Variable course in immunocompromised
48 Natural History / Prognosis Sudden erratic change- look for immunosuppression Malignant transformation Widespread mets and fatality has been reported (Sawai, JAAD 1996) Giant PM in acral locations w/ underlying soft tissue and bone destruction
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