egfr > 50 (n = 13,916)
|
|
- Drusilla Cobb
- 5 years ago
- Views:
Transcription
1 Saxagliptin and Cardiovascular Risk in Patients with Type 2 Diabetes Mellitus and Moderate or Severe Renal Impairment: Observations from the SAVOR-TIMI 53 Trial Supplementary Table 1. Characteristics according to Renal Function Characteristic egfr > 50 (n = 13,916) egfr 50 (n = 2,576) Demographic Characteristics Age years, Median (IQR) 64.0 ( ) 70.0 ( ) <.0001 Female sex, n(%) 4,355 (31.3%) 1,100 (42.7%) <.0001 Weight kg, Median (IQR) 86.1 ( ) 85.0 ( ) 0.03 Body-mass index - kg/m 2, Median (IQR) 30.4 ( ) 31.0 ( ) <.0001 Past Medical History Duration of diabetes, Median (IQR) 10.0 ( ) 13.6 ( ) <.0001 Established atherosclerotic disease, n(%) 10,809 (77.7%) 2,150 (83.5%) <.0001 Hypertension, n(%) 11,301 (81.2%) 2,191 (85.1%) <.0001 Dyslipidemia, n(%) 9,760 (70.1%) 1,979 (76.8%) <.0001 Prior myocardial infarction, n(%) 5,209 (37.4%) 1,028 (39.9%) 0.02 Prior heart failure, n(%) 1,577 (11.3%) 528 (20.5%) <.0001 Prior coronary revascularization, n(%) 5,900 (42.4%) 1,223 (47.5%) <.0001 Clinical and Laboratory Measurements Systolic blood pressure mmhg, Median (IQR) ( ) ( ) 0.18 Diastolic blood pressure mmhg, Median 80.0 ( ) 77.0 ( ) (IQR) HbA1c (%), Median (IQR) 7.6 ( ) 7.6 ( ) 0.24 HbA1c (mmol/mol), Median (IQR) 60 (52-72) 60 (52-72) 0.24 Fasting serum glucose (mg/dl), Median (IQR) ( ) ( ) <.0001 Estimated glomerular filtration rate ml/min, 75.6 ( ) 41.4 ( ) <.0001 Median (IQR) Albumin/creatinine ratio mg/mmol, Median 1.6 ( ) 5.9 ( ) <.0001 (IQR) Albumin/creatinine ratio, n(%) <.0001 < 3.4 mg/mmol 8,691 (65.3%) 1,005 (41.2%) mg/mmol 3,624 (27.2%) 802 (32.9%) > 33.9 mg/mmol 1,004 (7.5%) 634 (26.0%) Baseline Cardiovascular Medications Aspirin, n(%) 10,501 (75.5%) 1,903 (73.9%) 0.09 Statins, n(%) 10,814 (77.7%) 2,103 (81.6%) <.0001 Beta-Blockers, n(%) 8,379 (60.2%) 1,783 (69.2%) <.0001 Diuretics, n(%) 5,503 (39.5%) 1,695 (65.8%) <.0001 ACE Inhibitors, n(%) 7,611 (54.7%) 1,329 (51.6%) Angiotensin Receptor Blockers, n(%) 3,708 (26.6%) 887 (34.4%) <.0001 Calcium antagonists, n(%) 4,312 (31.0%) 1,066 (41.4%) <.0001 Baseline Anti-hyperglycemic Medications Metformin, n(%) 10,355 (74.4%) 1,118 (43.4%) <.0001 Sulfonylurea, n(%) 5,702 (41.0%) 931 (36.1%) <.0001 Thiazolidinediones, n(%) 831 (6.0%) 147 (5.7%) 0.60 Insulin, n(%) 5,380 (38.7%) 1,452 (56.4%) <.0001 None, n(%) 632 (4.5%) 103 (4.0%) 0.22 Abbreviations: egfr, estimated glomerular filtration rate, presented as ml/min/1.73m 2. P
2 Supplementary Table 2. Association of Renal Function and Cardiovascular Endpoints Adjusted for Clinical Findings and Urinary Albumin-to-Creatinine Ratio Outcome Hazard Ratio (95% CI) egfr > 50 egfr P egfr < 30 P CV Death, MI, Ischemic Stroke Referent 1.17 ( ) ( ) Hosp. for HF Referent 1.78 ( ) < ( ) <0.001 Patients are categorized into normal or mildly impaired renal function (egfr >50 ml/min/1.73m 2 ); moderate renal impairment (egfr ml/min/1.73m 2 ); or severe renal impairment (egfr <30 ml/min/1.73m 2 ). Covariates in the model include age, sex, current tobacco use, history of hypertension, history of hypercholesterolemia, prior cardiovascular disease, prior heart failure, and urinary albumin-to-creatinine ratio. Supplementary Table 3. Two-Year Cardiovascular Endpoints According to Renal Function Endpoint egfr > 50 ml/min/1.73m2 egfr 50 ml/min/1.73m 2 P Interaction Saxagliptin Placebo Hazard Ratio P Saxagliptin Placebo Hazard Ratio P 5 mg (n = 6986) (n = 6930) (95% CI) 2.5 mg (n = 1294) (n = 1282) (95% CI) CV Death, MI, Ischemic Stroke 6.55% 6.28% 1.01 ( ) % 12.3% 0.97 ( ) CV Death, MI, Ischemic Stroke, Hosp. for HF, Coronary 11.7% 11.1% 1.03 ( ) % 19.5% 1.00 ( ) Revascularization, UA CV Death 2.59% 2.28% 1.06 ( ) % 6.53% 0.98 ( ) MI 2.74% 3.06% 0.88 ( ) % 5.18% 1.16 ( ) Ischemic Stroke 1.94% 1.63% 1.12 ( ) % 1.88% 1.03 ( ) Hosp. for HF 2.46% 1.97% 1.23 ( ) % 7.22% 1.32 ( ) Abbreviations: CI indicates confidence interval; CV, cardiovascular; egfr, estimated glomerular filtration rate; Hosp., hospitalization; HF, heart failure; HR, hazard ratio; MI, myocardial infarction.
3 Supplementary Table 4. Frequency of Progressive Microalbuminuria by Completion of Follow-up According to Renal Function Total Worsened No Change Improved N (%) N (%) N (%) N (%) P-value* egfr > 50 ml/min/1.73m 2 (n = 10,621) < Saxagliptin 5,380 (50.7%) 682 (12.7%) 4,139 (76.9%) 559 (10.4%) Placebo 5,241 (49.3%) 790 (15.1%) 4,003 (76.4%) 448 (8.5%) egfr 50 ml/min/1.73m 2 (n = 1739) Saxagliptin 885 (50.9%) 151 (17.1%) 623 (70.4%) 111 (12.5%) Placebo 854 (49.1%) 179 (21.0%) 591 (69.2%) 84 (9.8%) The risk of progressive microalbuminuria was defined as a treatment difference in the number and proportion of patients with worsening, no change, or improvement in urinary albumin-to-creatinine ratio (ACR), defined as a shift from baseline category (<3.4, 3.4 to 33.9, or >33.9 mg/mmol) over the duration of follow-up among patients with complete data. *P-values based on chi-square or Fisher s exact test.
4 Supplementary Table 5. Frequency of Renal and Glycemic Endpoints According to Renal Function Endpoint egfr > 50 ml/min/1.73m 2 egfr 50 ml/min/1.73m 2 P Interaction Saxagliptin Placebo Hazard Ratio Saxagliptin Placebo Hazard Ratio 5 mg (n = 6986) (n = 6930) (95% CI) 2.5 mg (n = 1294) (n = 1282) (95% CI) Doubling of Serum Creatinine, Dialysis, Renal Transplant, 1.50% 1.22% 1.10 ( ) 5.80% 6.16% 1.06 ( ) 0.90 Serum Creatinine >6 mg/dl Doubling of Serum Creatinine, Dialysis, Renal Transplant, Serum Creatinine >6 mg/dl, Death 5.24% 4.41% 1.10 ( ) 13.9% 13.7% 1.06 ( ) 0.78 Hosp. for Hypoglycemia 0.44% 0.30% 1.44 ( ) 1.65% 1.82% 0.99 ( ) 0.36 Major Hypoglycemia 1.45% 1.30% 1.11 ( ) 5.60% 3.70% 1.58 ( ) 0.13 Initiation of Insulin Therapy 5.24% 7.66% 0.67 ( ) 7.14% 8.60% 0.87 ( ) 0.10 Addition or Increase of Any New Anti-Hyperglycemic Medication (including Insulin) 24.4% 30.1% 0.77 ( ) 20.0% 24.9% 0.81 ( ) 0.60 Abbreviations: CI indicates confidence interval; HR, hazard ratio; Hosp., hospitalization; egfr, estimated glomerular filtration rate. Interaction P-values based on categorical egfr groups. Supplementary Table 6. Frequency of Adverse Events According to Renal Function Safety Endpoint egfr > 50 ml/min/1.73m 2 egfr ml/min/1.73m 2 egfr < 30 ml/min/1.73m 2 Saxagliptin Placebo P Value* Saxagliptin Placebo P Value* Saxagliptin Placebo P Value* 5 mg (n = 6930) 2.5 mg (n = 1118) 2.5 mg (n = 164) (n = 6986) (n = 1122) (n = 172) Any Adverse Event 5079 (72.7%) 5054 (72.9%) (77.5%) 866 (77.5%) (88.4%) 126 (76.8%) Total Number of Events 24,797 24,815 5,448 4, Any Severe Adverse Event 1645 (23.5%) 1591 (23.0%) (35.9%) 412 (36.9%) (47.1%) 70 (42.7%) 0.42 Total Number of Events *P-values based on chi-square or Fisher s exact test.
5 Supplementary Figure 1. Two-year event rates for the composite of cardiovascular death, myocardial infarction, or ischemic stroke in patients stratified by renal function and cardiovascular disease status. Patients are categorized dichotomously into moderate-to-severe renal impairment (egfr 50 ml/min/1.73m 2 ) or not (egfr >50 ml/min/1.73m 2 ); with or without a prior history of established cardiovascular disease. Abbreviations: CV indicates cardiovascular; egfr, estimated glomerular filtration rate; MI, myocardial infarction.
6 Supplementary Figure 2. Relationship between egfr and the risk of the composite of cardiovascular death, myocardial infarction, or ischemic stroke The solid lines represent the adjusted point estimates for the risk of the composite endpoint of cardiovascular death, MI, or ischemic stroke by egfr, presented as ml/min/1.73m 2 ; black represents all patients, red represents patients assigned to saxagliptin, and blue represents patients assigned to placebo. The y-axis represents the log hazard ratio of the composite outcome. The red dotted line represents the reference level of egfr 86 ml/min/1.73m 2. The cubic spline function was adjusted for age, sex, current tobacco use, and history of hypertension, hypercholesterolemia, established cardiovascular disease, and heart failure. Abbreviations: CV indicates cardiovascular; egfr, estimated glomerular filtration rate; MI, myocardial infarction.
7 Supplementary Figure 3. Effect of saxagliptin on the risk of cardiovascular outcomes in patients categorized by estimated GFR. Patients are categorized according to baseline renal function as normal or mildly impaired (egfr > 50 ml/min/1.73m 2 ; N=13,916) or moderate-tosevere renal impairment (egfr 50 ml/min/1.73m 2 ; N=2576). Patients are categorized according to baseline renal function as normal or mildly impaired (egfr > 50 ml/min/1.73m 2 ; N=13,916) or moderate-to-severe renal impairment (egfr 50 ml/min/1.73m 2 ; N=2576). Shown are Kaplan-Meier (KM) rate estimates of each cardiovascular endpoint through 2 years in saxagliptin (S) and placebo (P) arms, respectively. The squares indicate the point estimate, and horizontal lines indicate the 95% confidence interval (CI) for the effect in each subgroup. Abbreviations: CV indicates cardiovascular; Cor. Revasc., coronary revascularization; HF, heart failure; HR, hazard ratio; hosp., hospitalization; egfr, estimated glomerular filtration rate; MI, myocardial infarction; UA, unstable angina. Interaction P-values based on categorical egfr groups.
Effect of Saxagliptin on Renal Outcomes in the SAVOR TIMI- 53 study- Appendixes:
Effect of Saxagliptin on Renal Outcomes in the SAVOR TIMI- 53 study- Appendixes: Appendix Table 1: Number and % of patients at the saxagliptin and placebo arms, according to egfr and on treatment ACR groups
More informationSupplementary Appendix
Supplementary Appendix This appendix has been provided by the authors to give readers additional information about their work. Supplement to: Wanner C, Inzucchi SE, Lachin JM, et al. Empagliflozin and
More informationOnline Appendix (JACC )
Beta blockers in Heart Failure Collaborative Group Online Appendix (JACC013117-0413) Heart rate, heart rhythm and prognostic effect of beta-blockers in heart failure: individual-patient data meta-analysis
More informationESC GUIDELINES ON DIABETES AND CARDIOVASCULAR DISEASES
ESC GUIDELINES ON DIABETES AND CARDIOVASCULAR DISEASES Pr. Michel KOMAJDA Institute of Cardiology - IHU ICAN Pitie Salpetriere Hospital - University Pierre and Marie Curie, Paris (France) DEFINITION A
More informationSupplementary Online Content
Supplementary Online Content Afkarian M, Zelnick L, Hall YN, et al. Clinical manifestations of kidney disease among US adults with diabetes, 1988-2014. JAMA. doi:10.1001/jama.2016.10924 emethods efigure
More informationA factorial randomized trial of blood pressure lowering and intensive glucose control in 11,140 patients with type 2 diabetes
A factorial randomized trial of blood pressure lowering and intensive glucose control in 11,140 patients with type 2 diabetes Hypotheses: Among individuals with type 2 diabetes, the risks of major microvascular
More informationSupplementary Table 1. Baseline Characteristics by Quintiles of Systolic and Diastolic Blood Pressures
Supplementary Data Supplementary Table 1. Baseline Characteristics by Quintiles of Systolic and Diastolic Blood Pressures Quintiles of Systolic Blood Pressure Quintiles of Diastolic Blood Pressure Q1 Q2
More informationGALECTIN-3 PREDICTS LONG TERM CARDIOVASCULAR DEATH IN HIGH-RISK CORONARY ARTERY DISEASE PATIENTS
GALECTIN-3 PREDICTS LONG TERM CARDIOVASCULAR DEATH IN HIGH-RISK CORONARY ARTERY DISEASE PATIENTS Table of Contents List of authors pag 2 Supplemental figure I pag 3 Supplemental figure II pag 4 Supplemental
More informationLowering blood pressure (BP) in patients with type 2
Average Clinician-Measured Blood Pressures and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus and Ischemic Heart Disease in the EXAMINE Trial William B. White, MD; Fatima Jalil, MD;
More informationADVANCE post trial ObservatioNal Study
Hot Topics in Diabetes 50 th EASD, Vienna 2014 ADVANCE post trial ObservatioNal Study Sophia Zoungas The George Institute The University of Sydney Rationale and Study Design Sophia Zoungas The George Institute
More informationNo Increased Cardiovascular Risk for Lixisenatide in ELIXA
ON ISSUES IN THE MANAGEMENT OF TYPE 2 DIABETES JUNE 2015 Coverage of data from ADA 2015, June 5 9 in Boston, Massachusetts No Increased Cardiovascular Risk for Lixisenatide in ELIXA First Cardiovascular
More informationSoo LIM, MD, PHD Internal Medicine Seoul National University Bundang Hospital
Soo LIM, MD, PHD Internal Medicine Seoul National University Bundang Hospital Agenda Association between Cardiovascular Disease and Type 2 Diabetes Importance of HbA1c Management esp. High risk patients
More informationThe EMPA-REG OUTCOME trial: Design and results. David Fitchett, MD University of Toronto, Canada
The EMPA-REG OUTCOME trial: Design and results David Fitchett, MD University of Toronto, Canada Asian Cardio Diabetes Forum April 23 24, 2016 Kuala Lumpur, Malaysia Life Expectancy Is Reduced by ~12 Years
More informationCardiovascular Diabetology. Open Access ORIGINAL INVESTIGATION. C. R. L. Cardoso 1, N. C. Leite 1, C. B. M. Moram 2 and G. F.
https://doi.org/10.1186/s12933-018-0677-0 Cardiovascular Diabetology ORIGINAL INVESTIGATION Open Access Long term visit to visit glycemic variability as predictor of micro and macrovascular complications
More informationUpdates in Diabetes and Cardiovascular Disease Management: Are You Making the Link?
Updates in Diabetes and Cardiovascular Disease Management: Are You Making the Link? Denise Kolanczyk, PharmD, BCPS AQ Cardiology 1 Erika Hellenbart, PharmD, BCPS 2 Jennifer D Souza, PharmD, CDE, BC ADM
More informationTrial to Reduce. Aranesp* Therapy. Cardiovascular Events with
Trial to Reduce Cardiovascular Events with Aranesp* Therapy John J.V. McMurray, Hajime Uno, Petr Jarolim, Akshay S. Desai, Dick de Zeeuw, Kai-Uwe Eckardt, Peter Ivanovich, Andrew S. Levey, Eldrin F. Lewis,
More informationDapagliflozin and cardiovascular outcomes in type 2
EARN 3 FREE CPD POINTS diabetes Leader in digital CPD for Southern African healthcare professionals Dapagliflozin and cardiovascular outcomes in type 2 diabetes Introduction People with type 2 diabetes
More informationAppendix This appendix was part of the submitted manuscript and has been peer reviewed. It is posted as supplied by the authors.
Appendix This appendix was part of the submitted manuscript and has been peer reviewed. It is posted as supplied by the authors. Appendix to: Banks E, Crouch SR, Korda RJ, et al. Absolute risk of cardiovascular
More informationGli endpoint micro-vascolari nei trial di outcome cardiovascolare
Gli endpoint micro-vascolari nei trial di outcome cardiovascolare Giorgio Sesti University Magna Graecia of Catanzaro ITALY Potenziali conflitti di interesse Il Prof Giorgio Sesti dichiara di aver ricevuto
More informationBeta-blockers in Patients with Mid-range Left Ventricular Ejection Fraction after AMI Improved Clinical Outcomes
Beta-blockers in Patients with Mid-range Left Ventricular Ejection Fraction after AMI Improved Clinical Outcomes Seung-Jae Joo and other KAMIR-NIH investigators Department of Cardiology, Jeju National
More information1. Albuminuria an early sign of glomerular damage and renal disease. albuminuria
1. Albuminuria an early sign of glomerular damage and renal disease albuminuria Cardio-renal continuum REGRESS Target organ damage Asymptomatic CKD New risk factors Atherosclerosis Target organ damage
More informationCARDIO-RENAL SYNDROME
CARDIO-RENAL SYNDROME Luis M Ruilope Athens, October 216 DISCLOSURES: ADVISOR/SPEAKER for Astra-Zeneca, Bayer, BMS, Daiichi-Sankyo, Esteve, GSK Janssen, Lacer, Medtronic, MSD, Novartis, Pfizer, Relypsa,
More informationA: Epidemiology update. Evidence that LDL-C and CRP identify different high-risk groups
A: Epidemiology update Evidence that LDL-C and CRP identify different high-risk groups Women (n = 27,939; mean age 54.7 years) who were free of symptomatic cardiovascular (CV) disease at baseline were
More informationLipoprotein(a), PCSK9 Inhibition and Cardiovascular Risk: Insights from the FOURIER Trial
Lipoprotein(a), PCSK9 Inhibition and Cardiovascular Risk: Insights from the FOURIER Trial Michelle L. O Donoghue, Robert P. Giugliano, Anthony C. Keech, Estella Kanevsky, KyungAh Im, Peter S. Sever, Terje
More informationManaging Dyslipidemia in Disclosures. Learning Objectives 03/05/2018. Speaker Disclosures
Managing Dyslipidemia in 2018 Glen J. Pearson, BSc, BScPhm, PharmD, FCSHP, FCCS Professor of Medicine (Cardiology) Co-Director, Cardiac Transplant Clinic; Associate Chair, Health Research Ethics Boards;
More informationThis clinical study synopsis is provided in line with Boehringer Ingelheim s Policy on Transparency and Publication of Clinical Study Data.
abcd Clinical Study Synopsis for Public Disclosure This clinical study synopsis is provided in line with s Policy on Transparency and Publication of Clinical Study Data. The synopsis which is part of the
More informationDECLARATION OF CONFLICT OF INTEREST
DECLARATION OF CONFLICT OF INTEREST Is there a mortality risk associated with aspirin use in heart failure? Results from a large community based cohort Margaret Bermingham, Mary-Kate Shanahan, Saki Miwa,
More informationCharacterization of Types and Sizes of Myocardial Infarction Reduced with Evolocumab in FOURIER
Characterization of Types and Sizes of Myocardial Infarction Reduced with Evolocumab in FOURIER Stephen D Wiviott, Robert P Giugliano, David A Morrow, Gaetano M De Ferrari, Basil S Lewis, Kurt Huber, Julia
More informationCanagliflozin for Primary and Secondary Prevention of Cardiovascular Events in Type 2 Diabetes: Results From the CANVAS Program
Canagliflozin for Primary and Secondary Prevention of Cardiovascular Events in Type 2 Diabetes: Results From the CANVAS Program Kenneth W. Mahaffey, Bruce Neal, Vlado Perkovic, Dick de Zeeuw, Greg Fulcher,
More informationSupplement materials:
Supplement materials: Table S1: ICD-9 codes used to define prevalent comorbid conditions and incident conditions Comorbid condition ICD-9 code Hypertension 401-405 Diabetes mellitus 250.x Myocardial infarction
More informationEffect of the PCSK9 Inhibitor Evolocumab on Cardiovascular Outcomes
Effect of the PCSK9 Inhibitor Evolocumab on Cardiovascular Outcomes MS Sabatine, RP Giugliano, SD Wiviott, FJ Raal, CM Ballantyne, R Somaratne, J Legg, SM Wasserman, R Scott, MJ Koren, and EA Stein for
More informationContemporary management of Dyslipidemia
Contemporary management of Dyslipidemia Todd Anderson Feb 2018 Disclosure Statement Within the past two years: I have not had an affiliation (financial or otherwise) with a commercial organization that
More informationCANVAS Program Independent commentary
CANVAS Program Independent commentary Cliff Bailey Aston University, Birmingham, UK 2017 Disclosures and disclaimers Clifford J Bailey CJB has attended advisory boards, undertaken ad hoc consultancy, received
More informationHFpEF, Mito or Realidad?
HFpEF, Mito or Realidad? Ileana L. Piña, MD, MPH Professor of Medicine and Epidemiology/Population Health Associate Chief for Academic Affairs -- Cardiology Montefiore-Einstein Medical Center Bronx, NY
More informationAntihypertensive Trial Design ALLHAT
1 U.S. Department of Health and Human Services Major Outcomes in High Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs Diuretic National Institutes
More informationData Analysis Plan for assessing clinical efficacy and safety of ER niacin/laropiprant in the HPS2-THRIVE trial
Data Analysis Plan for assessing clinical efficacy and safety of ER niacin/laropiprant in the HPS2-THRIVE trial 1 Background This Data Analysis Plan describes the strategy, rationale and statistical methods
More informationCKD FOR INTERNISTS. Dr Ahmed Hossain Associate professor Medicine Sir Salimullah Medical College
CKD FOR INTERNISTS Dr Ahmed Hossain Associate professor Medicine Sir Salimullah Medical College INTRODUCTION In 2002, the National Kidney Foundation s Kidney Disease Outcomes Quality Initiative(KDOQI)
More informationSTABILITY Stabilization of Atherosclerotic plaque By Initiation of darapladib TherapY. Harvey D White on behalf of The STABILITY Investigators
STABILITY Stabilization of Atherosclerotic plaque By Initiation of darapladib TherapY Harvey D White on behalf of The STABILITY Investigators Lipoprotein- associated Phospholipase A 2 (Lp-PLA 2 ) activity:
More informationDisclosures. Diabetes and Cardiovascular Risk Management. Learning Objectives. Atherosclerotic Cardiovascular Disease
Disclosures Diabetes and Cardiovascular Risk Management Tony Hampton, MD, MBA Medical Director Advocate Aurora Operating System Advocate Aurora Healthcare Downers Grove, IL No conflicts or disclosures
More informationEffective and Safe Management of Patients With Type 2 Diabetes and Chronic Kidney Disease Using Sitagliptin
2013 춘계당뇨병학회 Effective and Safe Management of Patients With Type 2 Diabetes and Chronic Kidney Disease Using Sitagliptin Eun Seok Kang Yonsei University College of Medicine Severance Hospital Diabetes
More informationThe Clinical Unmet need in the patient with Diabetes and ACS
The Clinical Unmet need in the patient with Diabetes and ACS Professor Kausik Ray (UK) BSc(hons), MBChB, MD, MPhil, FRCP (lon), FRCP (ed), FACC, FESC, FAHA Diabetes is a global public health challenge
More informationFelix Vallotton Ball (1899) LDL-C management in Asian diabetes: moderate vs. high intensity statin --- a lesson from EMPATHY study
Felix Vallotton Ball (1899) LDL-C management in Asian diabetes: moderate vs. high intensity statin --- a lesson from EMPATHY study Conflict of interest disclosure None Committee of Scientific Affairs Committee
More informationSupplementary Appendix
Supplementary Appendix This appendix has been provided by the authors to give readers additional information about their work. Supplement to: Rawshani Aidin, Rawshani Araz, Franzén S, et al. Risk factors,
More informationSupplementary appendix
Supplementary appendix This appendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors. Supplement to: Shah AD, Langenberg C, Rapsomaniki E, et al.
More informationSupplementary Online Content
Supplementary Online Content Nikolova AP, Hitzeman TC, Baum R, et al. Association of a novel diagnostic biomarker, the plasma cardiac bridging integrator 1 score, with heart failure with preserved ejection
More informationDiabetes and kidney disease.
Diabetes and kidney disease. What are the implications? Can it be prevented? Nice 18 june 2010 Lars G Weiss. M.D. Ph.D. Department of Neprology Central Hospital Karlstad Sweden Diabetic nephropathy vs
More informationPredicting and changing the future for people with CKD
Predicting and changing the future for people with CKD I. David Weiner, M.D. Co-holder, C. Craig and Audrae Tisher Chair in Nephrology Professor of Medicine and Physiology and Functional Genomics University
More informationPROTEZIONE DAL DANNO RENALE NEL DIABETE TIPO 2: RUOLO DEI NUOVI FARMACI. Massimo Boemi UOC Malattie Metaboliche e Diabetologia IRCCS INRCA Ancona
PROTEZIONE DAL DANNO RENALE NEL DIABETE TIPO 2: RUOLO DEI NUOVI FARMACI Massimo Boemi UOC Malattie Metaboliche e Diabetologia IRCCS INRCA Ancona Disclosure Dr Massimo Boemi has been granted as speaker
More information< N=248 N=296
Supplemental Digital Content, Table 1. Occurrence intraoperative hypotension (IOH) using four different thresholds of the mean arterial pressure (MAP) to define IOH, stratified for different categories
More informationCVD risk assessment using risk scores in primary and secondary prevention
CVD risk assessment using risk scores in primary and secondary prevention Raul D. Santos MD, PhD Heart Institute-InCor University of Sao Paulo Brazil Disclosure Honoraria for consulting and speaker activities
More informationRenal tubular secretion in chronic kidney disease: description, determinants, and outcomes. Astrid M Suchy-Dicey
Renal tubular secretion in chronic kidney disease: description, determinants, and outcomes Astrid M Suchy-Dicey A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor
More informationHypertension Management in Diabetic Patients
Hypertension Management in Diabetic Patients Park, Chang G, MD, PhD Cardiovascular Center, Guro Hospital, Korea University Medical School Contents (Treatment of 2 Cases) Type 2 Diabetes Mellitus Hypertension
More informationSupplementary Online Content
Supplementary Online Content Inohara T, Manandhar P, Kosinski A, et al. Association of renin-angiotensin inhibitor treatment with mortality and heart failure readmission in patients with transcatheter
More informationTreatment Of Preserved Cardiac Function Heart Failure with an Aldosterone antagonist (TOPCAT) AHA Nov 18, 2014 Update on Randomized Trials
Treatment Of Preserved Cardiac Function Heart Failure with an Aldosterone antagonist (TOPCAT) AHA Nov 18, 2014 Update on Randomized Trials Marc A. Pfeffer, MD, PhD; Brian Claggett, PhD; Susan F. Assmann,
More informationKidney and heart: dangerous liaisons. Luis M. RUILOPE (Madrid, Spain)
Kidney and heart: dangerous liaisons Luis M. RUILOPE (Madrid, Spain) Type 2 diabetes and renal disease: impact on cardiovascular outcomes The "heavyweights" of modifiable CVD risk factors Hypertension
More informationMacrovascular Residual Risk. What risk remains after LDL-C management and intensive therapy?
Macrovascular Residual Risk What risk remains after LDL-C management and intensive therapy? Defining Residual Vascular Risk The risk of macrovascular events and microvascular complications which persists
More informationEDMS #4298 Version 1.0
Randomized EValuation of the Effects of Anacetrapib through Lipid-modification (HPS3/TIMI55 REVEAL) Data Analysis Plan Version 1.0 1 Table of Contents 1 VERSION HISTORY... 2 2 INTRODUCTION... 3 2.1 BACKGROUND...
More informationSupplementary Online Content
Supplementary Online Content Lin Y-S, Chen Y-L, Chen T-H, et al. Comparison of Clinical Outcomes Among Patients With Atrial Fibrillation or Atrial Flutter Stratified by CHA 2 DS 2 -VASc Score. JAMA Netw
More informationSupplementary Material to Mayer et al. A comparative cohort study on personalised
Suppl. Table : Baseline characteristics of the patients. Characteristic Modified cohort Non-modified cohort P value (n=00) Age years 68. ±. 69.5 ±. 0. Female sex no. (%) 60 (0.0) 88 (.7) 0.0 Body Mass
More informationLEADER Liraglutide and cardiovascular outcomes in type 2 diabetes
LEADER Liraglutide and cardiovascular outcomes in type 2 diabetes Presented at DSBS seminar on mediation analysis August 18 th Søren Rasmussen, Novo Nordisk. LEADER CV outcome study To determine the effect
More informationQUICK REFERENCE FOR HEALTHCARE PROVIDERS
KEY MESSAGES 1 SCREENING CRITERIA Screen: Patients with DM and/or hypertension at least yearly. Consider screening patients with: Age >65 years old Family history of stage 5 CKD or hereditary kidney disease
More informationJohn J.P. Kastelein MD PhD Professor of Medicine Dept. of Vascular Medicine Academic Medial Center / University of Amsterdam
Latest Insights from the JUPITER Study John J.P. Kastelein MD PhD Professor of Medicine Dept. of Vascular Medicine Academic Medial Center / University of Amsterdam Inflammation, hscrp, and Vascular Prevention
More informationDiabete: terapia nei pazienti a rischio cardiovascolare
Diabete: terapia nei pazienti a rischio cardiovascolare Giorgio Sesti Università Magna Graecia di Catanzaro Cardiovascular mortality in relation to diabetes mellitus and a prior MI: A Danish Population
More informationDiabetes and the Heart
Diabetes and the Heart Jeffrey Boord, MD, MPH Advances in Cardiovascular Medicine Kingston, Jamaica December 6, 2012 Outline Screening for diabetes in patients with CAD Screening for CAD in patients with
More informationClinical Trial Synopsis TL-OPI-518, NCT#
Clinical Trial Synopsis, NCT# 00225264 Title of Study: A Double-Blind, Randomized, Comparator-Controlled Study in Subjects With Type 2 Diabetes Mellitus Comparing the Effects of Pioglitazone HCl vs Glimepiride
More informationFasting or non fasting?
Vascular harmony Robert Chilton Professor of Medicine University of Texas Health Science Center Director of Cardiac Catheterization labs Director of clinical proteomics Which is best to measure Lower continues
More informationProtecting the heart and kidney: implications from the SHARP trial
Cardiology Update, Davos, 2013: Satellite Symposium Protecting the heart and kidney: implications from the SHARP trial Colin Baigent Professor of Epidemiology CTSU, University of Oxford S1 First CTT cycle:
More informationSupplemental Table 1. Standardized Serum Creatinine Measurements. Supplemental Table 3. Sensitivity Analyses with Additional Mortality Outcomes.
SUPPLEMENTAL MATERIAL Supplemental Table 1. Standardized Serum Creatinine Measurements Supplemental Table 2. List of ICD 9 and ICD 10 Billing Codes Supplemental Table 3. Sensitivity Analyses with Additional
More informationStatin therapy in patients with Mild to Moderate Coronary Stenosis by 64-slice Multidetector Coronary Computed Tomography
Statin therapy in patients with Mild to Moderate Coronary Stenosis by 64-slice Multidetector Coronary Computed Tomography Hyo Eun Park 1, Eun-Ju Chun 2, Sang-Il Choi 2, Soyeon Ahn 2, Hyung-Kwan Kim 3,
More informationSupplementary Table 1. Patient demographics and baseline characteristics (treated patients).
Supplementary Table 1. Patient demographics and baseline characteristics (treated patients). Placebo (n=188) 10 mg (n=186) 25 mg (n=189) Total (n=563) Gender, n (%) Male 75 (40) 97 (52) 84 (44) 256 (45)
More informationTable S1: Diagnosis and Procedure Codes Used to Ascertain Incident Hip Fracture
Technical Appendix Table S1: Diagnosis and Procedure Codes Used to Ascertain Incident Hip Fracture and Associated Surgical Treatment ICD 9 Code Descriptions Hip Fracture 820.XX Fracture neck of femur 821.XX
More informationVariability in drug response: towards more personalized diabetes care Petrykiv, Sergei
University of Groningen Variability in drug response: towards more personalized diabetes care Petrykiv, Sergei IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you
More informationACCP Cardiology PRN Journal Club
ACCP Cardiology PRN Journal Club Announcements Next journal club Thursday, Dec. 14 th at 3:00 PM EST PACIFY Trial Effects of IV Fentanyl on Ticagrelor Absorption and Platelet Inhibition Among Patients
More informationAdult Diabetes Clinician Guide NOVEMBER 2017
Kaiser Permanente National CLINICAL PRACTICE GUIDELINES Adult Diabetes Clinician Guide Introduction NOVEMBER 2017 This evidence-based guideline summary is based on the 2017 KP National Diabetes Guideline.
More informationThe Diabetes Link to Heart Disease
The Diabetes Link to Heart Disease Anthony Abe DeSantis, MD September 18, 2015 University of WA Division of Metabolism, Endocrinology and Nutrition Oswald Toosweet Case #1 68 yo M with T2DM Diagnosed DM
More informationOral Hypoglycemics and Risk of Adverse Cardiac Events: A Summary of the Controversy
Oral Hypoglycemics and Risk of Adverse Cardiac Events: A Summary of the Controversy Jeffrey Boord, MD, MPH Advances in Cardiovascular Medicine Kingston, Jamaica December 7, 2012 VanderbiltHeart.com Outline
More informationThe CARI Guidelines Caring for Australasians with Renal Impairment. ACE Inhibitor and Angiotensin II Antagonist Combination Treatment GUIDELINES
ACE Inhibitor and Angiotensin II Antagonist Combination Treatment Date written: September 2004 Final submission: September 2005 Author: Kathy Nicholls GUIDELINES No recommendations possible based on Level
More informationDapagliflozin and Outcomes in Patients with Peripheral Artery Disease: Insights from DECLARE-TIMI 58
Dapagliflozin and Outcomes in Patients with Peripheral Artery Disease: Insights from DECLARE-TIMI 58 Marc P. Bonaca MD MPH for the DECLARE TIMI 58 Investigators American College of Cardiology March 2019
More informationEffects of Lowering LDL Cholesterol on Progression of Kidney Disease
Effects of Lowering LDL Cholesterol on Progression of Kidney Disease Richard Haynes, David Lewis, Jonathan Emberson, Christina Reith, Lawrence Agodoa, Alan Cass, Jonathan C. Craig, Dick de Zeeuw, Bo Feldt-Rasmussen,
More informationManagement of Type 2 Diabetes Cardiovascular Outcomes Trials Tom Blevins MD Texas Diabetes and Endocrinology Austin, Texas
Management of Type 2 Diabetes Cardiovascular Outcomes Trials 2018 Tom Blevins MD Texas Diabetes and Endocrinology Austin, Texas Speaker Disclosure Dr. Blevins has disclosed that he has received grant support
More informationPrevention And Treatment of Diabetic Nephropathy. MOH Clinical Practice Guidelines 3/2006 Dr Stephen Chew Tec Huan
Prevention And Treatment of Diabetic Nephropathy MOH Clinical Practice Guidelines 3/2006 Dr Stephen Chew Tec Huan Prevention Tight glucose control reduces the development of diabetic nephropathy Progression
More informationCardiologists and HbA1c: Novel Diabetes Drugs and Cardiovascular Disease Outcomes
Biomarkers 2018 Cardiologists and HbA1c: Novel Diabetes Drugs and Cardiovascular Disease Outcomes Gregg C. Fonarow, MD, FACC, FAHA, FHFSA Elliot Corday Professor of Cardiovascular Medicine UCLA Division
More informationAldosterone Antagonism in Heart Failure: Now for all Patients?
Aldosterone Antagonism in Heart Failure: Now for all Patients? Inder Anand, MD, FRCP, D Phil (Oxon.) Professor of Medicine, University of Minnesota, Director Heart Failure Program, VA Medical Center 111C
More informationCardiovascular Benefits of Two Classes of Antihyperglycemic Medications
Cardiovascular Benefits of Two Classes of Antihyperglycemic Medications Nathan Woolever, Pharm.D., Resident Pharmacist Pharmacy Grand Rounds November 6 th, 2018 Franciscan Healthcare La Crosse, WI 2017
More informationSPRINT: Consequences for CKD patients
SPRINT: Consequences for CKD patients 29 e Workshop Nierziekten Papendal 2018 December 12, 2018 MICHAEL ROCCO, MD, MSCE VARDAMAN M. BUCKALEW JR. PROFESSOR OF MEDICINE PROFESSOR OF PUBLIC HEALTH SCIENCES
More informationE.Ritz Heidelberg (Germany)
Predictive capacity of renal function in cardiovascular disease E.Ritz Heidelberg (Germany) If a cure is not achieved, the kidneys will pass on the disease to the heart Huang Ti Nei Ching Su Wen The Yellow
More informationCARDIOVASCULAR SAFETY OF FEBUXOSTAT OR ALLOPURINOL IN PATIENTS WITH GOUT AND CARDIOVASCULAR DISEASE (The CARES Trial)
CARDIOVASCULAR SAFETY OF FEBUXOSTAT OR ALLOPURINOL IN PATIENTS WITH GOUT AND CARDIOVASCULAR DISEASE (The CARES Trial) William B. White, MD for the CARES Investigators Calhoun Cardiology Center University
More informationEmpagliflozin: Role in Treatment Options for Patients with Type 2 Diabetes Mellitus
Diabetes Ther (2017) 8:33 53 DOI 10.1007/s13300-016-0211-x REVIEW Empagliflozin: Role in Treatment Options for Patients with Type 2 Diabetes Mellitus John E. Anderson. Eugene E. Wright Jr.. Charles F.
More informationMetabolic Syndrome and Chronic Kidney Disease
Metabolic Syndrome and Chronic Kidney Disease Definition of Metabolic Syndrome National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III Abdominal obesity, defined as a waist circumference
More informationSUPPLEMENTARY DATA. Supplementary Figure S1. Cohort definition flow chart.
Supplementary Figure S1. Cohort definition flow chart. Supplementary Table S1. Baseline characteristics of study population grouped according to having developed incident CKD during the follow-up or not
More informationT. Suithichaiyakul Cardiomed Chula
T. Suithichaiyakul Cardiomed Chula The cardiovascular (CV) continuum: role of risk factors Endothelial Dysfunction Atherosclerosis and left ventricular hypertrophy Myocardial infarction & stroke Endothelial
More informationEffective Health Care Program
Comparative Effectiveness Review Number 37 Effective Health Care Program Chronic Kidney Disease Stages 1 3: Screening, Monitoring, and Treatment Executive Summary Objectives This systematic review evaluates
More informationΣυμπεράσματα από τις νέες μελέτες για την αρτηριακή υπέρταση (SPRINT,PATHAY 2,HOPE 3)
Συμπεράσματα από τις νέες μελέτες για την αρτηριακή υπέρταση (SPRINT,PATHAY 2,HOPE 3) Χάρης Γράσσος MD,FESC,PhD,EHS Διευθυντής Καρδιολόγος Γ.Ν.Α ΚΑΤ Visiting Professor University of Bolton U.K New England
More informationCan We Reduce Heart Failure by Treating Diabetes? CVOT Data on SGLT2 Inhibitors and GLP-1Receptor Agonists
Can We Reduce Heart Failure by Treating Diabetes? CVOT Data on SGLT2 Inhibitors and GLP-1Receptor Agonists Robert R. Henry, MD Professor of Medicine University of California, San Diego Relevant Conflict
More informationWeigh the benefit of statin treatment: LDL & Beyond
Weigh the benefit of statin treatment: LDL & Beyond Duk-Woo Park, MD, PhD Heart Institute, University of Ulsan College of Medicine, Asan Medical, Seoul, Korea FOURIER Further cardiovascular OUtcomes Research
More informationRAS Blockade Across the CV Continuum
A Summary of Recent International Meetings RAS Blockade Across the CV Continuum Copyright New Evidence Presented at the 2009 Congress of the European Society of Cardiology (August 29-September 2, Barcelona)
More informationUniversity of Groningen. Evaluation of renal end points in nephrology trials Weldegiorgis, Misghina Tekeste
University of Groningen Evaluation of renal end points in nephrology trials Weldegiorgis, Misghina Tekeste IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish
More informationLife After CORAL: What Did CORAL Prove? David Paul Slovut, MD, PhD Co-director TAVR, Dir of Advanced Intervention
Life After CORAL: What Did CORAL Prove? David Paul Slovut, MD, PhD Co-director TAVR, Dir of Advanced Intervention No Relationships to Disclose The Need for Modern Renal Trials Increased rate of RAS diagnosis
More informationMethods. Background and Objectives STRADIVARIUS
STRADIVARIUS Effect of on Progression of Atherosclerosis in Patients with Abdominal Obesity and Coronary Artery Disease Steven E. Nissen MD Stephen J. Nicholls MBBS PhD, Kathy Wolski MPH, Josep Rodés-Cabau
More information(n=6279). Continuous variables are reported as mean with 95% confidence interval and T1 T2 T3. Number of subjects
Table 1. Distribution of baseline characteristics across tertiles of OPG adjusted for age and sex (n=6279). Continuous variables are reported as mean with 95% confidence interval and categorical values
More information