Undernutrition during conception and gestation: Increased risk for the next generation
|
|
- Marjory Hortense Andrews
- 5 years ago
- Views:
Transcription
1 Undernutrition during conception and gestation: Increased risk for the next generation Reinoud J.B.J. Gemke VU University Medical Center Amsterdam
2 Genetic disorders One gene => one phenotype => one disease Autosomal recessive Cystic fibrosis Sikkel cel anemia X linked Duchenne s muscular dystrophia Daltonism
3 Developmental Origin of Cardiovascular Risk Fetal and early postnatal cardiovascular risk factors Fetal growth retardation birth weight < p10, SGA Preterm birth Born < 37 wks gestational age Accelerated post natal growth Weight gain > 1 SDS
4 Genetic and epigenetic factors DNA 99% identical Gene polymorfism Epigenetic factors Affecting geneexpression without DNA differences DNA methylation DNA acetylation Histone modification
5 Epigenetics and the life cycle: lifelong remodeling
6 Genetic identical, different phenotype: Which mechanisms in early life? Phenotype determined by development in environment Role of insulin signaling pathway in gene-expression and phenotype of bee (queen) Wolschin, 2010
7 Gestational epigenetics affecting phenotype Genetically identical agouti mice Maternal suppletion with methyl donors (choline, folic acid, vitamin B12) Increased DNA methylation of Agouti gene Reduction of offspring with yellow coat (corresponds to risk of obesity and diabetes)
8 Relation of (early) nutrition with later health From empiric observation to epidemiologic study Granny s tales Fish oil and health Cod liver oil (n-3 and n-6 PUFA s, Vitamin D) Overall health and CZS development Folic acid and spina bifida (patho)physiologic mechanisms Experimental (animal) studies Subsequent intervention studies If/when feasible.
9 Early nutrition and later cardiovascular disease Epidemiologic (human) studies Hertfordshere, UK Dutch famine (+ 6 months) Helsinki birth cohort Confirmation (in experimental animal) studies IUGR rats Results from clinical human studies SGA children
10 Epidemiological studies CVD related mortality and birth weight in individuals in Hertfortshere. Birth weight kg Death ratio Death numbers < > Total Barker & Osmond 1986
11 Epidemiological studies Cardiovascular disease in Dutch famine study Coronary heart disease Sex adjusted OR 3.0 for individuals with early gestational famine exposure No increased prevalence in mid and late gestational famine exposure Blood pressure Relation birth weight adult blood pressure Most important determinant of high blood pressure is lower protein-carbohydrate ratio in last trimester of gestation. Fetal environment is a risk factor of coronary heart disease Roseboom, 2000 en Painter, 2006
12 Epidemiological studies Helsinki birth cohort study 7086 individuals born Detailed birth and growth data (6-16yr) OR type 2 diabetes 1.38 ( ) per kg lower birth weight OR type 2 diabetes 1.39 ( ) per 1 SDS weight gain during 6-16 yr of age Frosen et al, Ann Int Med 2000
13 Experimental animal studies Fetal growth redardation increases blood pressure and heart rate in aging rats. Schreuder, 2006
14 Experimental animal studies Fetal growth retardation vs adult heart rate and blood pressure Baseline and stressed conditions in (male) rats IUGR CTRL IUGR CTRL (Δ 8 mm Hg) R = 0.70 Schreuder, 2007
15 Clinical studies Mean carotid IMT at age 9 according to thirds of the distribution of current weight and maternal energy intake in late pregnancy Indicates fetal malnutrition Indicates accelerated post natal growth Gale CR, 2006
16 Clinical studies SGA AGA Controls SGA vs AGA AGA vs Controls N=21 N=29 N=30 Mean SD Mean SD Mean SD value P value Baseline SBP (mmhg) <0.001* Baseline DBP (mmhg) h blood pressure SBP (mmhg) * DBP (mmhg) Daytime blood pressure SBP (mmhg) * DBP (mmhg) Nighttime blood pressure SBP (mmhg) DBP (mmhg) Data expressed by mean [standard deviation (SD)] and regression P value adjusted for gender SGA small for gestational age prematurely bom individuals, AGA appropriate for gestational age prematurely bom individuals, controls appropriate for gestational age term-bom individuals, SBP systolic blood pressure, DBP diastolic blood pressure * P<0.05 Mean 24-h, daytime and night time blood pressure values in young adults, born as SGA and AGA preterms and controls Keizer-Veen MG, 2010
17 Developmental Origin of Health and Disease Percieved affluent optimal fetal environment Percieved sparse fetal environment Long(er) life expectancy Short(er) life expectancy Adaptation toward longevity - Aiming for regeneration and recovery - Building natural reserve : e.g. more neurons, nephrons - Big(ger) adults: bonemass, muscular mass Adaptation toward fetal survival - Intra-uterine growth retardation - Preterm birth Adapted reproduction - Early puberty and early offspring* Defense mechanisms (RR, HR) - Insulin resistence (type 2 diabetes) - Fat storage (dyslipidemia) - CNS adaptation - HPA-axis (stress response) - ADHD - Depression, Ψ disorders
18 Role of antenatal nutrition in the offspring Maternal malnutrition Fetal malnutrition Other maternal or placental abnormalities Other organ malfunction e.g. liver Decreased β cell mass Altered insulin sensitivity Abnormal vascular development Hyperlipidemia Non insulin-dependent diabetes Hypertension CVD and Metabolic syndrome Barker
19 Post-natal growth as determinant of adult disease Accelerated (catch-up) growth hypothesis Fast growth: Traditionally required for survival of (low birth weight) newborns Preterm (< 37 wks) SGA (< -2SD) Beneficial for cognitive development Increased survival discloses latent adult diseases Hypertension, CVD Type 2 diabetes Metabolic syndrome Singhal A, Lancet 2004
20 Early life and later cardiovascular disease Fetal growth retardation (+10%, steady) Preterm birth (9-12%, max 18%, increasing due to ART) Accelerated (catch up) postnatal growth Centile crossing
21 Contribution of fetal and (early) post natal growth in the development and prevention of CVD Good body of evidence Large effect size Long term scope Prevention cost-effective Mechanism revealing studies (Potential) effect in Different populations and Different environment Adult Adolescent periconceptional Child Environmental (vs genetic factors) factors in the transgenerational perspective of CVD fetus Infant
22 ABCD study Amsterdam Born Children and their Development study Birth cohort, including data of >5000 children from 1st trimester pregnancy until age 5 (2010), and will continue every 5 yrs until 20. Early determinants of cardiovascular function, stress (HPA axis), behaviour and cognition Particular attention for ethnic differences Collaboration of Municipal Health Service Amsterdam Academic Medical Center Amsterdam VU University Medical Center, Amsterdam Find us at:
23 The people who do the work Manon van Eijsden, Municipal Health Service, Amsterdam Tanja Vrijkotte, Academic Medical Center, Amsterdam Reinoud Gemke, VU University Medical Center, Amsterdam Marieke de Beer Aimee van Dijk Marieke de Hoog PhD students Eva Loman Gerrit van der Berg
24
25 New model Any neonate No acceleration in weight gain Accelerated weight gain (especially in the first 3 month of life) Fat accumulation during infancy and childhood Insulin sensitivity Unfavourable body composition Unfavourable lipid profile Blood pressure No higher risk Development of adult disease
26 Fetal growth and birth weight Determinants for adult health and disease Cardiovascular disease Hypertension Diabetes type 2 Dyslipidaemia Metabolic syndrome Osteoporosis Sub/infertility CZS disorders Depression ADHD Psychiatric disorders Increased mortality
27 Is birth weight related to insuline sensitivity? Variables Birth weight SDS Adult weight SDS Fat mass (kg) Lean body mass (kg) Insuline sensitivity Insuline sensitivity Insuline sensitivity B P-value B P-value B P-value 0,146 0,049 0,115 0,098 0,083 0,210-0,199 <0,001-0,044 <0,001-0,002 0,840 Adjusted for age, gender, SES, birth lenght SDS, adult height SDS * Log transformed Leunissen R. 2008
28 Early life: Predictive adaptive response Gluckman 2004
29 Gluckman 2004
30 Life course approach Chronic disease risk Developmental Plasticity Response to new challenge
31 IUGR and control rats Significant differences in cytosine methylation Yellow: DNA hypomethylation Red: DNA hypermethylation Thompson RF, 2010
32 Versnelde ( inhaal )groei en etniciteit Brinkkemper & Vrijkotte, 2007
33 Developmental programming of cardiovascular disease Short cohort description Aim of the study
Timing and tempo of first year growth in relation to cardiovascular and metabolic risk profile in early adulthood
Note: for non-commercial purposes only Timing and tempo of first year growth in relation to cardiovascular and metabolic risk profile in early adulthood Anita Hokken-Koelega Professor of Pediatric Endocrinology
More informationEarly Origins of Metabolic Disease and Aging
1 Early Origins of Metabolic Disease and Aging Janet C. King, Ph.D. Senior Scientist, Children s Hospital Oakland Research Institute And Professor Emeritus, UC Berkeley & Davis 2 The Maternal Nutrition-Offspring
More informationBMI may underestimate the socioeconomic gradient in true obesity
8 BMI may underestimate the socioeconomic gradient in true obesity Gerrit van den Berg, Manon van Eijsden, Tanja G.M. Vrijkotte, Reinoud J.B.J. Gemke Pediatric Obesity 2013; 8(3): e37-40 102 Chapter 8
More informationSocioeconomic inequalities in lipid and glucose metabolism in early childhood
10 Socioeconomic inequalities in lipid and glucose metabolism in early childhood Gerrit van den Berg, Manon van Eijsden, Francisca Galindo-Garre, Tanja G.M. Vrijkotte, Reinoud J.B.J. Gemke BMC Public Health
More informationIUGR AND LONG TERM CV FUNCTION
IUGR AND LONG TERM CV FUNCTION Eduard Gratacós www.fetalmedicinebarcelona.org www.fetalmedicinebarcelona.org/ 1. Fetal growth and cardiovascular function 2. IUGR and cardiac programming 3. Clinical implications
More informationMetabolic Programming. Mary ET Boyle, Ph. D. Department of Cognitive Science UCSD
Metabolic Programming Mary ET Boyle, Ph. D. Department of Cognitive Science UCSD nutritional stress/stimuli organogenesis of target tissues early period critical window consequence of stress/stimuli are
More informationRole of vitamin D and folate towards the genetic potential in early life and adult phenotypes
Role of vitamin D and folate towards the genetic potential in early life and adult phenotypes Emeritus Professor Khor Geok Lin Universiti Putra Malaysia Jakarta 13 th November, 2016 The author declares
More informationPaul Hofman. Professor. Paediatrician Endocrinologist Liggins Institute, The University of Auckland, Starship Children Hospital, Auckland
Professor Paul Hofman Paediatrician Endocrinologist Liggins Institute, The University of Auckland, Starship Children Hospital, Auckland 9:25-9:50 Endocrine and Metabolic Consequences of Being Born Preterm
More informationPost Discharge Nutrition. Jatinder Bhatia, MD, FAAP
Post Discharge Nutrition Jatinder Bhatia, MD, FAAP Declaration of potential conflicts of interest Regarding this presentation the following relationships could be perceived as potential conflicts of interest:
More informationFetal Programming and the Leningrad Siege Study
ARTICLES Fetal Programming and the Leningrad Siege Study Sara A. Stanner 1 and John S.Yudkin 2 1 British Nutrition Foundation, London 2 International Health and Medical Education Centre, University College
More informationProf C.S. Yajnik MD,FRCP KEM HOSPITAL, PUNE, INDIA
Trans-generational impact of the double burden of malnutrition A case study from India Prof C.S. Yajnik MD,FRCP KEM HOSPITAL, PUNE, INDIA www.kemdiabetes.org Life can only be understood backwards - Soren
More informationEpigenetics 101. Kevin Sweet, MS, CGC Division of Human Genetics
Epigenetics 101 Kevin Sweet, MS, CGC Division of Human Genetics Learning Objectives 1. Evaluate the genetic code and the role epigenetic modification plays in common complex disease 2. Evaluate the effects
More informationDevelopmental Origins of Health and Disease
Developmental Origins of Health and Disease Roles of Maternal Nutrition Matthew W. Gillman, MD, SM Harvard University Thanks to Faculty, Trainees, & Staff Obesity Prevention Program Department of Population
More informationInstitute of Developmental Sciences and DOHaD Centre. Healthy Cardiovascular Ageing: the life course perspective Mark
Institute of Developmental Sciences and DOHaD Centre Healthy Cardiovascular Ageing: the life course perspective Mark Hanson @MarkHansonUoS 1 Unlike communicable diseases, globally everyone is at risk of
More informationEarly Diet = Lifelong Health for Generations
Early Diet = Lifelong Health for Generations Thank you to: The Late David JP Barker & Helsinki Epidemiology Group OHSU Pregnancy & Fetal Development Group Center for Developmental Health Knight Cardiovascular
More informationPerinatal Programming Prenatal Determinants of Future Hypertension and CV Disease
Perinatal Programming Prenatal Determinants of Future Hypertension and CV Disease Julie R. Ingelfinger, M.D. Professor of Pediatrics, Harvard Medical School Senior Consultant in Pediatric Nephrology, MassGeneral
More informationPrenatal alcohol exposure and metabolic disease in adulthood
8 th International Research Conference on Adolescents and Adults with FASD Prenatal alcohol exposure and metabolic disease in adulthood Prof Karen Moritz Director Child Health Research Centre University
More informationLONG TERM IMPACT OF MALNUTRITION IN PREGNANCY
LONG TERM IMPACT OF MALNUTRITION IN PREGNANCY Fetal origins of chronic disease Dr Sabby Kant GPSI Cardiology My Objectives This Evening is to. make you think of your lovely mum & your BW introduce you
More informationCardiovascular fetal programming and remodelling Long term effects of adverse fetal environment on the heart
Cardiovascular fetal programming and remodelling Long term effects of adverse fetal environment on the heart Eduard Gratacos Maternal-Fetal Medicine Department and Research Center Hospital Clinic - University
More informationEarly Nutrition: the opportunity for childhood obesity prevention
Early Nutrition: the opportunity for childhood obesity prevention Prof. Cristina Campoy Department of Paediatrics. University of Granada. Spain Member of the ESPGHAN Committee on Nutrition HIGH LEVEL GROUP
More informationDEVELOPMENTAL ORIGINS OF DIABETES AND CARDIOVASCULAR DISEASE. Goals
DEVELOPMENTAL ORIGINS OF DIABETES AND CARDIOVASCULAR DISEASE Goals Evolutionary paradox of obesity/diabetes Thrifty gene hypothesis Thrifty phenotype hypothesis Effects of small for gestational age (SGA)
More informationChildhood Undernutrition: a biological perspective
Childhood Undernutrition: a biological perspective Vinod Paul MD, PhD, FIAP, FNNF, FAMS ALL INDIA INSTITUTE OF MEDICAL SCIENCES, NEW DELHI WHO Collaborating Centre for Training an Research in Newborn Care
More informationMaternal Nutrition. Rachel N Musoke Paediatrician/neonatologist University of Nairobi Department of Paediatrics & Child Health
Maternal Rachel N Musoke Paediatrician/neonatologist University of Nairobi Department of Paediatrics & Child Health 1 Introduction Sustainable Developments Goals (SDGs): End all forms of malnutrition by
More informationPerinatal maternal alcohol consumption and methylation of the dopamine receptor DRD4 in the offspring: The Triple B study
Perinatal maternal alcohol consumption and methylation of the dopamine receptor DRD4 in the offspring: The Triple B study Elizabeth Elliott for the Triple B Research Consortium NSW, Australia: Peter Fransquet,
More informationOHSU Moore Institute for Nutrition & Wellness OHSU School of Medicine. Diane Stadler, PhD, RD Graduate Programs in Human Nutrition
OHSU Moore Institute for Nutrition & Wellness OHSU School of Medicine Diane Stadler, PhD, RD Graduate Programs in Human Nutrition Moore Institute for Nutrition & Wellness There is no question that a nutritious,
More informationPERINATAL AND CHILDHOOD ORIGINS OF CARDIOVASCULAR DISEASE
PERINATAL AND CHILDHOOD ORIGINS OF CARDIOVASCULAR DISEASE Rae-Chi Huang, M.B., B.S., D.C.H., FRACP and Lawrie Beilin, M.B.B.S., M.D., FRCP, FRACP, AO, School of Medicine and Pharmacology, Royal Perth Hospital,
More informationReview Article Current Thoughts on Maternal Nutrition and Fetal Programming of the Metabolic Syndrome
Journal of Pregnancy Volume 2013, Article ID 368461, 13 pages http://dx.doi.org/10.1155/2013/368461 Review Article Current Thoughts on Maternal Nutrition and Fetal Programming of the Metabolic Syndrome
More informationTransgenerational Effects of Diet: Implications for Cancer Prevention Overview and Conclusions
Transgenerational Effects of Diet: Implications for Cancer Prevention Overview and Conclusions John Milner, Ph.D. Director, USDA Beltsville Human Nutrition Research Center Beltsville, MD 20705 john.milner@ars.usda.gov
More informationThe Epigenetics of Obesity: Individual, Social, and Environmental Influences. K. J. Claycombe, Ph.D.
The Epigenetics of Obesity: Individual, Social, and Environmental Influences K. J. Claycombe, Ph.D. What can happen to our gene(s) that would cause obesity? Modification via Epigenetic alterations C
More informationNeonatal Hypoglycemia. Presented By : Kamlah Olaimat 25\7\2010
Neonatal Hypoglycemia Presented By : Kamlah Olaimat 25\7\2010 Definition The S.T.A.B.L.E. Program defines hypoglycemia as: Glucose delivery or availability is inadequate to meet glucose demand (Karlsen,
More informationEpigenetic processes are fundamental to development because they permit a
Early Life Nutrition and Epigenetic Markers Mark Hanson, PhD Epigenetic processes are fundamental to development because they permit a range of phenotypes to be formed from a genotype. Across many phyla
More informationMaternal and Fetal Complications in Diabetes Pregnancy
Maternal and Fetal Complications in Diabetes Pregnancy Helen R Murphy Professor of Medicine (Diabetes & Antenatal Care), UEA Professor of Women s Health, Kings College London hm386@medschl.cam.ac.uk 1
More informationProf.dr. Frans J Kok. Nutrition & Health Perspectives over the Life course
Prof.dr. Frans J Kok Nutrition & Health Perspectives over the Life course Midlife Early life Midlife Late life Double Burden of Malnutrition Global population in 2015 and 2060 Modern Science and Technology
More informationPreface Acknowledgments Introduction Introductory Concepts Definitions and Context Chronological Age and Age Groups Why Study These Phenomena?
Preface Acknowledgments Introduction Introductory Concepts Definitions and Context Chronological Age and Age Groups Why Study These Phenomena? Types of Studies Principles of Measurement and Observation
More informationAN INTRODUCTION TO EPIGENETICS DR CHLOE WONG
AN INTRODUCTION TO EPIGENETICS DR CHLOE WONG MRC SGDP CENTRE, INSTITUTE OF PSYCHIATRY KING S COLLEGE LONDON Oct 2015 Lecture Overview WHY WHAT EPIGENETICS IN PSYCHIARTY Technology-driven genomics research
More informationFeeding the Small for Gestational Age Infant. Feeding the Small for Gestational Age Infant
Feeding the Small for Gestational Age Infant Feeding the Small for Gestational Age Infant What s the right strategy? Infants born small-for-gestational age (SGA) are at higher risk for adult diseases.
More informationDevelopmental programming in maternal diabetes and obesity
Developmental programming in maternal diabetes and obesity Frans André Van Assche Department of Obstetrics and Gynecology, University Hospital, K. U. Leuven, Herestraat 49, 3000 Leuven, Belgium Corresponding
More informationDoes (rapid) early weight gain cause adult disease and obesity? Ines M. Anchondo DrPH, RD, CSP
Does (rapid) early weight gain cause adult disease and obesity? Ines M. Anchondo DrPH, RD, CSP Annotated Reference List Adair, L. S., et al. (2009). "Size at birth, weight gain in infancy and childhood,
More informationFetal origins of adult disease: strength of effects and biological basis
International Epidemiological Association 2002 Printed in Great Britain International Journal of Epidemiology 2002;31:1235 1239 FETAL ORIGINS Fetal origins of adult disease: strength of effects and biological
More informationEndothelial function is impaired in women who had pre-eclampsia
Endothelial function is impaired in women who had pre-eclampsia Christian Delles, Catriona E Brown, Joanne Flynn, David M Carty Institute of Cardiovascular and Medical Sciences University of Glasgow United
More informationJAI La Leche League Epigenetics and Breastfeeding: The Longterm Impact of Breastmilk on Health Disclosure Why am I interested in epigenetics?
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 JAI La Leche League Epigenetics and Breastfeeding: The Longterm Impact of Breastmilk on Health By Laurel Wilson, IBCLC, CLE, CCCE, CLD Author of The Greatest Pregnancy
More informationIndia is one of the diabetes capitals of the world and at the same time the capital
Yajnik Undernutrition and Overnutrition During Pregnancy in India: C. S. Yajnik, MD, FRCP India is one of the diabetes capitals of the world and at the same time the capital for low birth weight (LBW)
More informationCommunity Genetics. Hanan Hamamy Department of Genetic Medicine & Development Geneva University Hospital
Community Genetics Hanan Hamamy Department of Genetic Medicine & Development Geneva University Hospital Training Course in Sexual and Reproductive Health Research Geneva 2011 Definition of Community Genetics
More informationDoes (rapid) early weight gain cause adult disease and obesity? Objectives. What does the literature have to say about rapid early. consequences?
Does (rapid) early weight gain cause adult disease and obesity? Ines M. Anchondo DrPH, RD, CSP Ellyn Satter, MS, RD, LCSW, BCD February 21, 2013 Objectives Explain what is rapid early infant weight gain
More informationEsther Briganti. Fetal And Maternal Health Beyond the Womb: hot topics in endocrinology and pregnancy. Endocrinologist and Clinician Researcher
Fetal And Maternal Health Beyond the Womb: hot topics in endocrinology and pregnancy Esther Briganti Endocrinologist and Clinician Researcher Director, Melbourne Endocrine Associates Associate Professor,
More informationINTRAUTERINE GROWTH RESTRICTION AND ITS IMPACT ON CARDIAC FUNCTION AND ARTERIAL COMPLIANCE IN THE YOUNG CHILD
INTRAUTERINE GROWTH RESTRICTION AND ITS IMPACT ON CARDIAC FUNCTION AND ARTERIAL COMPLIANCE IN THE YOUNG CHILD Edgar Jaeggi, MD, FRCPC Associate Scientist, RI Fetal Cardiac Program, The Hospital for Sick
More informationPregnancies complicated by diabetes. Marina Mickleson Nurse Practitioner Midwife CDE
Pregnancies complicated by diabetes Marina Mickleson Nurse Practitioner Midwife CDE Two types Pre gestational Gestational diabetes Both types are on the increase Pre conception work up is imperative for
More informationBlood Pressure and Metabolic Risk: From Birth to Adulthood
Blood Pressure and Metabolic Risk: Fro Birth to Adulthood Epar Lurbe, MD, PhD, FAHA Cardiovascular Risk Unit Hospital General Universitario University of Valencia CIBERObn Instituto de Salud Carlos III
More informationNutrition & Physical Activity Profile Worksheets
Nutrition & Physical Activity Profile Worksheets In these worksheets you will consider nutrition-related and physical activity-related health indicators for your community. If you cannot find local-level
More informationEllen Anckaert, Sergio Romero, Tom Adriaenssens, Johan Smitz Follicle Biology Laboratory UZ Brussel, Brussels
Effects of low methyl donor levels during mouse follicle culture on follicle development, oocyte maturation and oocyte imprinting establishment. Ellen Anckaert, Sergio Romero, Tom Adriaenssens, Johan Smitz
More informationWhat is gestational diabetes?
ESPEN Congress Cannes 2003 Organised by the Israel Society for Clinical Nutrition Education and Clinical Practice Programme Session: Dietitian Symposium: Nutrition throughout the woman life cycle An Update
More informationPROJECT Ntshembo: Improving adolescent health and interrupting mother-infant transfer of health risk in Africa. INDEPTH Network
PROJECT Ntshembo: Improving adolescent health and interrupting mother-infant transfer of health risk in Africa INDEPTH Network Overview Transitions across countries Transitions within countries - South
More informationMaternal and child nutrition: effects on health and development throughout the life course. Christine P. Stewart, MPH, PhD September 2012
Maternal and child nutrition: effects on health and development throughout the life course Christine P. Stewart, MPH, PhD September 2012 Outline Nutrition and epidemiologic transition Nutrition in pregnancy
More informationTHE FIRST NINE MONTHS AND CHILDHOOD OBESITY. Deborah A Lawlor MRC Integrative Epidemiology Unit
THE FIRST NINE MONTHS AND CHILDHOOD OBESITY Deborah A Lawlor MRC Integrative Epidemiology Unit d.a.lawlor@bristol.ac.uk Sample size (N of children)
More informationStudy of Serum Uric Acid Level in Adolescents Who Were Born Preterm
International Journal of Biotechnology and Biochemistry ISSN 0973-2691 Volume 14, Number 3 (2018) pp. 193-197 Research India Publications http://www.ripublication.com Study of Serum Uric Acid Level in
More informationLong-chain n-3 fatty acids in seafood and child nutrition
Long-chain n-3 fatty acids in seafood and child nutrition Lotte Lauritzen, Faculty of Life Sciences, Copenhagen University, Denmark LL 24/4-2007, DTU ph.d.course Nordic recommendations Infants 6-12 mo
More informationDevelopmental origins of type 2 diabetes in children. DCPNS April 16, 1010
Developmental origins of type 2 diabetes in children DCPNS April 16, 1010 Is there an early window of opportunity? Target pre-pregnancy to impact risk of type 2 diabetes for future generations of children
More informationA NEW RISK FACTOR FOR EARLY HEART FAILURE: PRETERM BIRTH
A NEW RISK FACTOR FOR EARLY HEART FAILURE: PRETERM BIRTH 1* Paul Leeson, PhD, FRCP and 1 Adam J. Lewandowski, DPhil 1 Oxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine,
More informationPCOS. pregnancy complications. Prof. Bart CJM Fauser. Dept. Reproductive Medicine and Gynecology. University Medical Center, Utrecht, The Netherlands
PCOS pregnancy complications Prof. Bart CJM Fauser Dept. Reproductive Medicine and Gynecology University Medical Center, Utrecht, The Netherlands Disclosure of interest, Fauser Professor of Reproductive
More informationEarly Growth and Later Atherosclerosis
Shamir R, Turck D, Phillip M (eds): Nutrition and Growth. World Rev Nutr Diet. Basel, Karger, 2013, vol 106, pp 162 167 (DOI: 10.1159/000342580) Early Growth and Later Atherosclerosis Atul Singhal Childhood
More informationPersonality and physiological reactions to acute psychological stress in a large cohort of middle aged men and women
Personality and physiological reactions to acute psychological stress in a large cohort of middle aged men and women Adam Bibbey, BSc 1 Douglas Carroll 1, Tessa J. Roseboom 2, Anna C. Phillips 1, Susanne
More informationHypertension Management Controversies in the Elderly Patient
Hypertension Management Controversies in the Elderly Patient Juan Bowen, MD Geriatric Update for the Primary Care Provider November 17, 2016 2016 MFMER slide-1 Disclosure No financial relationships No
More informationEarly Nutrition and Adult Noncommunicable. that must be broken
Early Nutrition and Adult Noncommunicable diseases: A vital link that must be broken Commonwealth Health Ministers Meeting WHO, Geneva May 14, 2011 Anna Lartey (Associate Professor) Department of Nutrition
More informationHypoglycemia. Objectives. Glucose Metabolism
Hypoglycemia Instructor: Janet Mendis, MSN, RNC-NIC, CNS Outline: Janet Mendis, MSN, RNC-NIC, CNS Summer Morgan, MSN, RNC-NIC, CPNP UC San Diego Health System Objectives State the blood glucose level at
More informationGrowth, Development, Nutrition & Ageing Module Year 2 Semester II (2014/15 Batch)
Growth, Development, Nutrition & Ageing Module Year 2 Semester II (2014/15 Batch) Web Copy Final document - revised on 01 st February, 2018 Concept Objectives Time Department T / L Activity At the end
More informationPRE GESTATIONAL DIABETES. Conflicts
PRE GESTATIONAL DIABETES Christopher Goodier, MD Assistant Professor, Maternal Fetal Medicine Medical University of South Carolina Conflicts I have no relevant disclosures or conflict of interest with
More informationMany epidemiological studies have shown that people
Fetal, Infant, and Childhood Growth and Adult Blood Pressure A Longitudinal Study From Birth to 22 Years of Age C.M. Law, MD, FRCP, FFPHM, FRCPCH; A.W. Shiell, BSc, MSc; C.A. Newsome, MA(Ed), PhD; H.E.
More informationMaternal and Infant Nutrition Briefs
Maternal and Infant Nutrition Briefs A research-based newsletter prepared by the University of California for professionals interested in maternal and infant nutrition March/April 2003 New Guidelines on
More informationObjectives. Neonatal Nutrition, Growth and Neurodevelopment. Brain Development through Term Gestation
Objectives Neonatal Nutrition, Growth and Neurodevelopment Sara Ramel MD Assistant Professor Division of Neonatology University of Minnesota Children s Hospital sramel@umn.edu Influence of growth and nutrition
More informationSummary. Introduction. Richard G. IJzerman a, Dorret I. Boomsma b and Coen D. A. Stehouwer a
Blackwell Science, LtdOxford, UKPPEPaediatric and Perinatal Epidemiology0269-5022Blackwell Publishing Ltd, 200419S11014Original ArticleBirthweight and cardiovascular risk factorsr. G. IJzerman et al. 10
More informationShould We Promote Catch-Up Growth or Growth Acceleration in Low-Birthweight Infants?
Catch-Up Growth Embleton ND, Katz J, Ziegler EE (eds): Low-Birthweight Baby: Born Too Soon or Too Small. Nestlé Nutr Inst Workshop Ser, vol 81, pp 51 60, ( DOI: 10.1159/000365803 ) Nestec Ltd., Vevey/S.
More informationJOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 2009, 60, Suppl 3,
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 2009, 60, Suppl 3, 17-35 www.jpp.krakow.pl P. GUILLOTEAU 1, R. ZABIELSKI 2, H.M. HAMMON 3, C.C. METGES 3 ADVERSE EFFECTS OF NUTRITIONAL PROGRAMMING DURING PRENATAL
More informationHypertension. Does it Matter What Medications We Use? Nishant K. Sekaran, M.D. M.Sc. Intermountain Heart Institute
Hypertension Does it Matter What Medications We Use? Nishant K. Sekaran, M.D. M.Sc. Intermountain Heart Institute Hypertension 2017 Classification BP Category Systolic Diastolic Normal 120 and 80 Elevated
More informationHolistic Approach to Nutrition and Development
Southampton Global Health Research Institute Exploring commonalities in Global Health Research 2 Workshop 15 June 2016 Holistic Approach to Nutrition and Development Rihlat SAID-MOHAMED MRC/Wits Developmental
More informationMaternal and Child Undernutrition 2 Maternal and child undernutrition: consequences for adult health and human capital
Maternal and Child Undernutrition 2 Maternal and child undernutrition: consequences for adult health and human capital Cesar G Victora, Linda Adair, Caroline Fall, Pedro C Hallal, Reynaldo Martorell, Linda
More informationEpidemiology and Prevention
Epidemiology and Prevention Associations of Pregnancy Complications With Calculated Cardiovascular Disease Risk and Cardiovascular Risk Factors in Middle Age The Avon Longitudinal Study of Parents and
More informationThere is growing evidence of an increasingly
Heart 2000;84:219 226 CONGENITAL HEART DISEASE Fetal and infant markers of adult heart diseases Marjo-Riitta Järvelin Department of Public Health Science and General Practice, University of Oulu, Finland
More informationSAB Report to the Board of the Glass Packaging Institute
SAB Report to the Board of the Glass Packaging Institute A Brief Overview of Significant Studies on BPA During 2013 November, 2013 Glass is ENDLESSLY Recyclable Introduction Number and diversity of studies
More informationESP 755A SUMMER Multiple Choice Identify the choice that best completes the statement or answers the question. 1. Autosomal recessive disorders
ESP 755A SUMMER 2017 Multiple Choice Identify the choice that best completes the statement or answers the question. 1. Autosomal recessive disorders a. affect only males c. are caused when the abnormal
More informationDiabetes in Pregnancy. L.Sekhavat MD
Diabetes in Pregnancy L.Sekhavat MD Diabetes in Pregnancy Gestational Diabetes Pre-gestational diabetes (overt) Insulin dependent (type1) Non-insulin dependent (type 2) Definition Gestational diabetes
More informationDEVELOPING A PROPOSAL. Marjo-Riitta Jarvelin, Professor Director of Postgraduate Studies. (PhD studies)
DEVELOPING A PROPOSAL Marjo-Riitta Jarvelin, Professor Director of Postgraduate Studies (PhD studies) PROJECT PLAN SOME PRINCIPLES a project should be planned so that a thesis can be written and submitted
More informationExercise as an intervention to improve metabolic outcomes after intrauterine growth restriction
Am J Physiol Endocrinol Metab 306: E999 E1012, 2014. First published March 11, 2014; doi:10.1152/ajpendo.00456.2013. Exercise as an intervention to improve metabolic outcomes after intrauterine growth
More informationHypoxia-Dependent Epigenetic Modifications in the Pulmonary Vasculature
Hypoxia-Dependent Epigenetic Modifications in the Pulmonary Vasculature I have no financial disclosures or conflicts of interest Sheila Krishnan, D.O. 10th International Conference Neonatal & Childhood
More informationMATERNAL INFLUENCES ON OFFSPRING S EPIGENETIC AND LATER BODY COMPOSITION
Institute of Medicine & National Research Council Food and Nutrition Board & Board on Children, Youth & Families Examining a Developmental Approach to Childhood Obesity: The Fetal & Early Childhood Years
More informationProgramming of NCDs in Preterm Infants Focus on Growth
Note: for non-commercial purposes only Power of Programming 13 th Oct 2016 Programming of NCDs in Preterm Infants Focus on Growth Ken Ong Programme Leader MRC Epidemiology Unit, IMS, University of Cambridge,
More informationThe role of fetal programming in pathogenesis of arterial hypertension and kidney disease in the adult life
22. NATIONAL CONGRESS OF RENAL DISEASES, DIALYSIS & TRANSPLANTATION NURSING 29. NATIONAL CONGRESS OF NEPHROLOGY, HYPERTENSION DIALYSIS & TRANSPLANTATION Antalya, 14-18 November 2012 The role of fetal programming
More informationDisclosure. Michael K. Georgieff, MD Research Support: Mead Johnson Nutrition Brain Iron Deficiency
Disclosure In accordance with the Accreditation Council for Continuing Medical Education Standards, parallel documents from other accrediting bodies, and Annenberg Center for Health Sciences policy, the
More informationWhen should you treat blood pressure in the young?
ESC Stockholm - Dilemmas in Cardiovascular Disease Prevention in the Young: 30 th August 2010 When should you treat blood pressure in the young? Bryan Williams MD FRCP FAHA FESC Professor of Medicine Department
More informationGESTATIONAL DIABETES for GP Obstetric Shared Care Accreditation Seminar. Simon Kane March 2016
GESTATIONAL DIABETES for GP Obstetric Shared Care Accreditation Seminar Simon Kane March 2016 Objectives History and definitions Definition and Australian data Pathophysiology and prevalence Rationale
More informationCOMMITTEE FOR MEDICINAL PRODUCTS FOR HUMAN USE (CHMP)
European Medicines Agency London, 15 November 2007 Doc. Ref. EMEA/CHMP/EWP/517497/2007 COMMITTEE FOR MEDICINAL PRODUCTS FOR HUMAN USE (CHMP) GUIDELINE ON CLINICAL EVALUATION OF MEDICINAL PRODUCTS USED
More informationPrematurity: Optimizing Growth in the NICU for Later Metabolic Outcomes
Prematurity: Optimizing Growth in the NICU for Later Metabolic Outcomes Malki Miller MS, RD, CNSC Neonatal Dietitian, Maimonides Infants and Children s Hospital Adjunct Lecturer of Human and Pediatric,
More informationAdvancing Policy Dialogue on Maternal Health Maternal Undernutrition: Evidence, Links, and Solutions
Advancing Policy Dialogue on Maternal Health Maternal Undernutrition: Evidence, Links, and Solutions Amy Webb Girard Assistant Professor of Maternal and Child Nutrition Hubert Department of Global Health
More informationThe Lancet Series on Maternal and Child Nutrition Launch Symposium 6 June, 2013
The Lancet Series on Maternal and Child Nutrition Launch Symposium 6 June, 2013 Imperial College St Mary s Campus Rothschild Lecture Hall, School of Medicine Norfolk Place, London Maternal and Child Undernutrition
More informationProfessor Joseph HADDAD Pediatric Department Saint George Univ Hosp Balamand Univ Beirut Lebanon
Nutrition & Growth in Premature Infant Professor Joseph HADDAD Pediatric Department Saint George Univ Hosp Balamand Univ Beirut Lebanon PART ONE : THE GROWTH OF THE PREMATURE INFANT ARE WE ON THE RIGHT
More informationGestational Diabetes: Long Term Metabolic Consequences. Outline 5/27/2014
Gestational Diabetes: Long Term Metabolic Consequences Gladys (Sandy) Ramos, MD Associate Clinical Professor Maternal Fetal Medicine Outline Population rates of obesity and T2DM Obesity and metabolic syndrome
More informationType 2 Diabetes in Adolescents
Type 2 Diabetes in Adolescents Disclosures Paid consultant, Eli Lilly, Inc, Pediatric Type 2 Diabetes Clinical Trials Outline The burden of diabetes Treatment and Prevention Youth Diabetes Prevention Clinic
More informationThe Role of Epigenetic Regulation in the Development of Obesity: A Comprehensive Review
The Role of Epigenetic Regulation in the Development of Obesity: A Comprehensive Review Brendan Scot Tanner 1 * and Cristina Hanganu-Bresch 1 1 in 6 children and 1 in 3 adults in the United States are
More informationEARLY BRAIN AND CHILDHOOD DEVELOPMENT
EARLY BRAIN AND CHILDHOOD DEVELOPMENT WILLIAM M BELLAS, DO, FAAP SANFORD CHILDREN S HOSPITAL DIVISION OF NEONATAL-PERINATAL MEDICINE CLINICAL ASSOCIATE PROFESSOR OF PEDIATRICS UND SCHOOL OF MEDICINE &
More informationToward guidelines for maternal and infant nutrition to influence long-term health of the offspring: The past and future of ILSI Europe work on
Toward guidelines for maternal and infant nutrition to influence long-term health of the offspring: The past and future of ILSI Europe work on metabolic imprinting Ricardo Rueda, MD PhD Abbott Nutrition
More informationLifelong Monitoring of HIV-Exposed Uninfected Infants is CRUCIAL! Jennifer Jao, MD, MPH Icahn School of Medicine at Mount Sinai
Lifelong Monitoring of HIV-Exposed Uninfected Infants is CRUCIAL! Jennifer Jao, MD, MPH Icahn School of Medicine at Mount Sinai Increasing numbers of HEUs Worldwide 1.800.000 1.600.000 1.400.000 1.200.000
More information