Medium as your dissemination Why learn if you can t teach it? Deepens understanding Stay engaged with the course Team-building

Transcription

1 Meet your TAs!

2 Blog Posts

3 Medium as your dissemination Why learn if you can t teach it? Deepens understanding Stay engaged with the course Team-building

4 Account information Come up with a group name (Should be your Medium account name) Make a new gmail account which you can link to your new medium account. Share both the and Medium account information with your groups when you make them.

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6 *4 1 - Longcut to writing a blog-post 2 - Read your other blog posts 3 - Write an illustrated story for use on mobile (probably won t be using this) 4 - Find past years with the tag Cogs163

7 The Story Will be published under your group name. Please make the writing both informative, but fun. Write to your audience Will be one blog entry per week per group on that week s topic

8 Tags and other things After writing, please tag the story with relevant topics As well as COGS163 (no space) Your group account will be ed confirmation of publishing. CC your TAs so we can read them easier.

9 Grading / final notes This will count towards the blog portion of your grade Updates to your group blog entries are due every Sunday by 11:59 p.m us your group name otherwise we cannot find you! Won t get credit! Work within your groups to divide up responsibilities. Everyone should be writing an equal amount of the posts.

10 How to Read a Paper

11 Two Ways to Read a Paper

12 Grad Perspective

13 Let s Begin- Way #1

14 General Big Picture

15 Definition Check

16 Definition Check Part 2

17 The First Pass

18 The First Pass: Read the Abstract

19 Abstract Summary

20 Review- Your Nervous System Comes in Two Parts

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22 How Your Autonomic Nervous System Works

23 CNS RECEPTORS S U UL M I ST RESPONSE EFFECTOR ORGAN to k l a s t r!!! n e ga Or anoth w Ho one

24 The First Pass: Read the Conclusions THE PARASYMPATHETIC SIGNALLING PATHWAY ISLET OF LANGERHANS β Dorsal Motor Nucleus of the Vagus Intrapancreatic Ganglia Postganglionic β Nerve β VAGUS NERVE INSULIN

25 Inhibiting/Stimulating Insulin Release Dorsal Motor Nucleus Vagus Ach Nerve Stimulation Postganglionic Ach Islet Muscarinic Nerve (m3) Receptors Nicotinic Receptors Hexamethonium Agonist Exogenous Ach Atropine Agonist Insulin Release

26 Also... Vagus Ach Nerve Postganglionic Ach Islet Muscarinic Nerve (m3) Receptors Nicotinic Receptors Glucagon Glycogen Breakdown Increases Blood Glucose Pancreatic Polypeptide (PP) Somatostatin Pancreatic Self-Regulation Inhibits Insulin and Glucagon Gastric Juice Secretion Reduces Stomach Acid Secretion

27 Read the Introduction- In this case, the bulk of the paper

28 Background- Receptors

29 Figure 2 m3 Ach Receptors

30 m3 Ach Receptors in Beta Cells Ach PLA2 PLC + + Gq + PI Arachidonic Acid DAG PIP2 + IP3 Calcium INSULIN RELEASE Carbachol PKC

31 Figure 2 Other Receptors

32 Other Types of Receptors in Beta Cells + Adenylate Cyclase Gs ATP camp INSULIN RELEASE

33 Figure 2 GRP Receptors

34 Other Types of Receptors in Beta Cells GRP + PLC/ PLD Gq DAG PIP2 INSULIN RELEASE Calcium + IP3 Carbachol PKC

35 Figure 2 Sympathetic Signaling

36 THE SYMPATHETIC SIGNALLING PATHWAY Hypothalamus ISLET OF LANGERHANS Celiac/Paravertebral Ganglia β Postg anglio n Nerve ic Spinal Cord (Levels C8-L3) SPLANCHNIC NERVE β β INSULIN

37 Regulating Insulin Release Sympathetic Ganglion NE Postganglionic Nerve Adrenoceptors NE Beta Cell β2 adrenoceptors Insulin Release Beta Cell 2 adrenoceptors Atropine Phentolamine (alpha antagonist) Hexamethonium Clonidine (alpha agonist) Alpha Cell β2 and 2 adrenoceptors Glucagon Release

38 And... Sympathetic Nerve Stimulation Glucagon Glycogen Breakdown Increases Blood Glucose Pancreatic Polypeptide (PP) IN HI BI TS Somatostatin Pancreatic Self-Regulation Inhibits Insulin and Glucagon Gastric Juice Secretion Reduces Stomach Acid Secretion

39 Other Things to Know about the SNS Non-adrenergic mechanisms

40 Figure 2 Non-Adrenergic Mechanisms

41 Sensory Nerves

42 Other Nerves

43 Figure 2 CCK Receptors

44 Figure 1

45 Figure 2 All the parts together

46 The Experiment- Cephalic Phase INSULIN

47 Cephalic Phase (sorry not sorry)

48 The Experiment

49 Figure 3 Trimetophane Saline

50 Synchronization of Islet Function

51 Homeostatic Mechanisms STRESS SYMPATHETIC NS ACTIVITY

52 Homeostatic Mechanisms EXERCISE SYMPATHETIC NS ACTIVITY

53 Homeostatic Mechanisms BLOOD VOLUME SYMPATHETIC NS ACTIVITY

54 Insulin Resistance

55 Food for Thought Billy and Bree s Slides