RESEARCHER DEVELOPMENT DAYS 2016/2017. Wednesday 30 November 2016

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1 RESEARCHER DEVELOPMENT DAYS 2016/2017 Wednesday 30 November 2016 Seminar Room 02/6008, 2 nd Floor UCL Centre for Nephrology Royal Free Hospital Rowland Hill Street London, NW3 2PF DELEGATE PACK Kidney Research UK Alumni: alumni@kidneyresearchuk.org Facebook: The Alumni programme has been supported by financial grants from a number of industry partners

2 Please complete, remove and return this page of the pack to Kidney Research UK staff on the day. YOUR FEEDBACK IS VERY IMPORTANT TO US! Researcher Development Day (London) November 2016: Feedback Thank you for joining us at this workshop. To help us continue to tailor our workshops for alumni appropriately, please would you give your feedback and answers to the questions below. Programme Rating Poor Average Good V/Good Excellent Speakers Overall 1: 2: 3: 4: 5: - Professor Fred Tam 1: 2: 3: 4: 5: - Dr Claire Sharpe 1: 2: 3: 4: 5: - Professor David Wheeler 1: 2: 3: 4: 5: Programme Structure 1: 2: 3: 4: 5: Interactive Afternoon Session 1: 2: 3: 4: 5: Information prior to event 1: 2: 3: 4: 5: Venue 1: 2: 3: 4: 5: Staff Service 1: 2: 3: 4: 5: How useful did you find this workshop? (which aspects did you find most beneficial?) What would you like to see in future programmes? (including grants workshop topics and keynote talks) Was this workshop held at the right time of year? (did it clash with another workshop or seminar that you also wanted to attend? Please give details and your reasons for choosing Kidney Research UK over the other/s) Thinking about this year, have you attended/will you attend similar events hosted by other charities/organisations? (please give an idea of how many and who hosts these events) What other support do you require to enhance your research career? What delivery mechanism do you think would be best utilised to provide this? (for example, F2F workshops; webinars; social networking sites) Any Final Comments: ***Thank you for completing this feedback form*** Name (optional):

3 RESEARCHER DEVELOPMENT DAYS 2016/17 Wednesday 30 November 2016 Seminar Room 02/6008, 2nd Floor, UCL Centre for Nephrology Royal Free Hospital, Rowland Hill Street London, NW3 2PF Arrival and Refreshments PROGRAMME Welcome and introductions Professor Adrian Woolf, Chair of Paediatric Science, University of Manchester, Kidney Research UK Trustee and Alumni Ambassador Keynote research topic/presentation From cell culture to clinical trial: Spleen Tyrosine Kinase (SYK) as a novel therapeutic target in IgA nephropathy Professor Fred Tam, Professor of Renal Medicine, Imperial College London Research Fellow career story Dr Claire Sharpe, Clinical Senior Lecturer and Honorary Consultant in Renal Medicine at King s College London/King s College Hospital LUNCH Interactive workshop including presentations, questions, breakout sessions How to get your work published Preparing your manuscript Choosing the right journal Responding to reviewers comments Professor David Wheeler, Professor of Kidney Medicine, Centre of Nephrology, University College London Networking and tea/coffee/biscuits The next Researcher Development Day will be on 6 February 2017, at the University of Leeds, and will again include a session on getting your work published. More information will be available here in due course:

4 SPEAKER BIOGRAPHIES Professor Fred Tam is the Professor of Medicine at Imperial College London. His research training was supported by a Medical Research Council Training Fellowship and a Kidney Research UK Senior Fellowship. He has been investigating the importance of cytokines in pathogenesis of glomerulonephritis, diabetic nephropathy and renal allograft rejection. Fred has set up cross-boundary collaboration and patient-focused research. His research group has developed experimental therapies of glomerulonephritis using soluble cytokine receptor, receptor antagonist and monoclonal antibodies, recombinant regulatory cytokines and signal transduction inhibitors. He has also applied the experience from cytokine analysis and proteomics to development of non-invasive biomarkers for glomerulonephritis, for diabetic nephropathy and for complications in peritoneal dialysis patients (in collaboration with Professor Edwina Brown). Together with Professor David Taube and the Transplantation Translational Research Group, he is investigating the novel mechanisms of renal transplant rejection and developing novel anti-rejection therapy (supported by Kidney Research UK Making Every Kidney Count Programme Grant). The expertise of his research group has been applied in the preclinical and early clinical development of anti-inflammatory therapies, in collaboration with the industry. Fred is the Principal Investigator of an international randomised controlled clinical trial of a Spleen Tyrosine Kinase (Syk) inhibitor in the treatment of IgA nephropathy. ( He is also the Founding Lead of the UK Rare Disease Group for Retroperitoneal Fibrosis ( Together with Professor Robert Unwin (Royal Free Hospital, University College London), he has established the Purinergic Receptor Research Consortium in order to investigate the novel function of purinergic receptors in regulating inflammasome and cytokine secretions in renal diseases. Together with Dr Andrew Frankel, they have established the Diabetic Nephropathy Translational Research Consortium to investigate novel disease mechanisms and to develop new therapy. Dr Claire Sharpe xxx. Professor David Wheeler is Professor of Kidney Medicine at University College London. He is a Clinician Scientist with an interest in the complications of chronic kidney disease, specifically those that increase the burden of cardiovascular disease and/or accelerate progression of kidney failure. He has participated in the design, roll out and monitoring of several large-scale clinical trials. He was a member of the steering committee of the Study of Heart and Renal Protection (SHARP), the EValuation Of Cinacalcet HCl Therapy to Lower CardioVascular Events (EVOLVE) and currently sits on the steering committee of Canaglifozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation

5 (CREDENCE), acting as UK principle investigator for this study. He is Clinical Lead for Division 2 of the North Thames Clinical Research Network and has involvement in Guideline Development for several organisations, most recently for Kidney Disease, Improving Global Outcomes, of which he is currently co-chair. A past president of the Renal Association, he leads a team of 8 clinical Trials nurses/practitioners at the Centre for Nephrology, Royal Free Hospital. Professor Wheeler is an Associate Editor of NDT and Member of the Editorial Board of JASN.

6 PRESENTATION SUMMARIES Keynote Presentation From cell culture to clinical trial: Spleen Tyrosine Kinase (SYK) as a novel therapeutic target in IgA nephropathy Professor Fred Tam In my talk, I shall share our experience of how laboratory research may be useful in identifying novel therapeutic targets in kidney diseases. The challenge and excitement of setting up clinical trials will be discussed. The recent work with Spleen Tyrosine Kinase (SYK) in renal diseases will be used as an example. Career Development Talk Dr Claire Sharpe In my talk How to get your work published Professor David Wheeler Career Story Interactive Session This session will cover key points in writing a manuscript in order to enhance your chances of publication. The choice of Journal will be discussed and the stages of the submissions process explained. Communications with the editor and responses to the reviewers comments will be covered using examples of submitted papers.