Design of polypill for treatment of type -II diabetes mellitus associated with dyslipidemia

Size: px
Start display at page:

Download "Design of polypill for treatment of type -II diabetes mellitus associated with dyslipidemia"

Transcription

1 556 Journal of Scientific & Industrial Research J SCI IND RES VOL 71 AUGUST 2012 Vol. 71, August 2012, pp Design of polypill for treatment of type -II diabetes mellitus associated with dyslipidemia Rohan D Deshpande 1 *, D.V. Gowda 1, Vasanti S 2, Nawaz Mahammed 1 1 JSS College of pharmacy, JSS University, S.S Nagar, Mysore , India 2 PES College of pharmacy, Hanumanthanagar, Bangalore , India Received 07 March 2012; revised 07 July 2012; accepted 11 July 2012 This study presents development of a bilayered tablet with sustained release (SR) of Metformin hydrochloride (MH) and immediate release of Atorvastatin calcium (AC), used as anti-hyperglycemic agent in patients with type 2 diabetes, by lowering both basal and postprandial plasma glucose and competitive inhibitor of HMG-CoA reductase. In SR layer, sodium carboxy methyl cellulose (Sodium CMC) and Hydroxy Propyl Methylcellulose K4M (HPMC K4M) were used as retarding material but Hydroxy Propyl Methylcellulose 15 Cps (HPMC 15 Cps) was used as channeling agent. Tablets were prepared by wet granulation method. FT-IR studies showed no interaction between drugs and polymers used in the study. Optimized formulation gave an initial burst effect and followed by SR for 8 h (92.53%), without any drug degradation during stability studies. Drug release from formulation was dose dependent and by diffusion mechanism. Keywords: Atorvastatin calcium (AC), HPMC 15Cps, HPMC K4M, Metformin hydrochloride (MH), Sodium CMC Introduction Bilayered tablet requires fewer materials than compression-coated tablets, weigh less and may be thinner 1. Bilayer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances, and also for sustained release (SR) tablet, in which one layer is immediate release (IR) as initial dose and second layer is maintenance dose 2. Higher rate of mortality in patients with diabetes mellitus patients is mainly due to cardiovascular diseases 3. Patients with type 2 diabetes have increased risk of atherosclerosis and it can be treated with statins 4,5. Blood glucose level impairs endothelial function and promotes atherogenesis in diabetic patients, and combined administration of metformin and atorvastatin prevent Endotheliumdependent dilation in patients compared with metformin alone 5,6. Mortality of diabetic patients after a cardiac event is significantly increased as compared to nondiabetics 7. Drugs should be stable in gastro-intestinal tract as SR systems release their contents over entire length of gastro-intestinal tract. Metformin hydrochloride (MH: biological half-life, 2-4 h) is an orally administered biguanide, which is widely used in management of *Author for correspondence rohan11in@gmail.com type-2 diabetes. It is a hydrophilic drug and is slowly and incompletely absorbed from gastrointestinal tract and absolute bioavailability of a single 500 mg dose is reported to be 50-60% 1. SR formulation that maintains plasma levels of drug for 8-12 h might be sufficient for once daily dosing for MH. Atorvastatin calcium (AC) mimics activity of HMG-CoA reductase by blocking rate-limiting step of cholesterol biosynthesis. It reduces LDL cholesterol, apolipoprotein B and triglycerides and increases HDL in treatment of hyperlipidaemia. Atorvastatin is rapidly absorbed after oral administration; maximum plasma concentration occurs within 1-2 h and half-life in humans is 14 h 8. This study presents development of a bilayered tablet with SR of MH and IR of AC, used as anti-hyperglycemic agent in patients with type 2 diabetes, by lowering both basal and postprandial plasma glucose and competitive inhibitor of HMG-CoA reductase. Experimental Section MH (mol wt, ; plasma elimination half-life, 2-4 h; apparent volume of distribution, 654±358 l) was a gift sample from Apotex India Ltd. It is soluble in water and methanol and practically insoluble in acetone and methylene chloride. AC (mol wt, ; plasma elimination half-life, 14 h; mean volume of distribution,

2 DESHPANDE et al: DESIGN OF POLYPILL FOR TYPE -II DIABETES MELLITUS 557 Table 1 Ingredients (mg/tablet) for Metformin HCl sustained release layer Ingredients SR1 SR2 SR3 SR4 SR5 SR6 SR7 Metformin HCl Sodium CMC HPMC 15Cps HPMC K4M DCP anhydrous Povidone (K-30) Purified water q.s q.s q.s q.s q.s q.s q.s Aerosil Talc Magnesium stearate Total weight of layer- I l), a gift sample from Maithri Laboratories Pvt Ltd, India, is soluble in dimethyl sulphoxide. Sodium carboxy methyl cellulose (Sodium CMC) was obtained from Pioma Chemicals, India. Hydroxy propyl methylcellulose K4M (HPMC K4M) and hydroxy propyl methylcellulose 15 Cps (HPMC 15 Cps) were procured from Enar chemicals, India.Lactose was obtained from DMV international, Netherlands. Croscarmellose sodium was obtained from hetero drugs as gift sample. All other chemicals used were of analytical grade. Drug-excipients Compatibility Studies MH and AC were taken in glass vials individually and along with various excipients (1:1). All mixtures of drug and excipients were kept at various accelerated condition (30ºC/65% RH and 40ºC/75% RH) in stability chamber for one month. At 2 weeks time interval and at the end of 4 th week, samples were withdrawn and checked out for any changes in physical character like color. Finally, combination of excipients with no colour change was selected for formulation. Preparation of Sustained Release Layer of Metformin Hydrochloride (MH) SR layer of Metformin, each containing MH (500 mg), were prepared by a conventional wet granulation technique (Table 1). All ingredients (MH, HPMC K4M, HPMC 15Cps, sodium CMC, dicalcium phosphate anhydrous) were passed through sieve no. 40. Povidone (K-30) was dissolved in purified water. Granules were prepared in rapid mixer granulator by adding binder solution to mixture of above ingredients and mixing at slow speed. MH granules were dried in fluidized bed dryer at 50ºC. Dried granules were passed through 20 mesh sieve. Shifted granules were transferred to double cone blender. Colloidal silicon dioxide was sifted through 40 mesh sieve, and magnesium stearate and talc were sifted through 60 mesh sieve and added to double cone blender and mixed for 2 min. Preparation of Immediate Release Layer of Atorvastatin Calcium (AC) IR layer of AC were prepared by wet granulation process (Table 2). Weighed AC, lactose monohydrate, microcrystalline cellulose, croscarmellose sodium and colloidal silicon dioxide were sifted through 40 mesh sieve and ponceu 4R supra was sifted through 100 mesh sieve. These ingredients were loaded into planetary mixture and mixed for 15 min at fast speed. Binder solution, prepared by dissolving polysorbate-80 in purified water, was added slowly to mixed contents in planetary mixer and mixed at slow speed for 5 min. Wet granules were loaded into fluidized bed dryer and dried at 50-60ºC. Produced granules were sized by sifting through 20 mesh sieve. In lubrication step, magnesium stearate, talc and sodium bicarbonate were sifted through 60 mesh sieves and croscarmellose sodium was sifted through 40 mesh sieve. Then, granules and lubricants were loaded into double cone blender and mixed for 3 min at slow speed. Prior to compression, granules were evaluated for characteristic parameters (bulk density, tapped density, compressibility index and hausner s ratio). Carr s compressibility index was calculated from bulk and tapped densities using a digital tap density apparatus (Electrolab Ltd. India). Preparation of Bilayer Formulation Final bilayer tablets (Fig. 1) were compressed as one layer only for MH (SR7) and second layer for AC (FR5) using 19.2 mm x 8.9 mm oblong shaped punch in

3 558 J SCI IND RES VOL 71 AUGUST 2012 Table 2 Ingredients (mg/tablet) for Atorvastatin Calcium immediate release layer Ingredients FR1 FR2 FR3 FR4 FR5 Atorvastatin Calcium Calcium carbonate Lactose monohydrate Micro crystalline cellulose Colloidal silicon dioxide Croscarmellose sodium Ponceu 4R Supra Purified water q.s q.s q.s q.s q.s Polysorbate Talc Magnesium stearate Croscarmellose sodium Sodium bicarbonate Total weight of layer- II Total weight of bilayer tablet a) b) Fig. 1 Bilayer tablets of Metformin HCl (MH) and Atorvastatin Calcium (AC): a) heap of tablets; and b) sides of tablets 27 station tablet compression machine (Cadmach, India). MH granules were introduced first into die cavity and slightly pre compressed. After that, AC granules were added and a final compression was made. Film Coating of Bilayer Tablets of MH and AC Coating Solution Preparation Over head stirrer was operated containing sufficient quantity of isopropyl alcohol and methylene chloride to form a mixture. To this, Transparent Coat IC-U-6638 was added in vortex without formation of lumps and continuously stirred for 45 min for homogenization. Coating solution was filtered through 200 mesh nylon cloth and used for coating of bilayer core tablets. Film Coating of Tablets Compressed tablets were loaded into Neocota coating machine containing pan and tablets were film coated to get the build of 2.0% with following parameters: pan speed, 5 rpm; gun type, spray gun; inlet temp., C; outlet temp., 30 Cl; and spray rate, 3 ml/min. Physical Tests for Bilayer Tablets Standard physical test for bilayer tablets were performed and average values were calculated. Weight variation was determined by weighing 20 tablets individually, average mass was calculated and variation% of each tablet was calculated. Hardness was determined by taking 6 tablets from each formulation using a Monsanto hardness tester (Tab machine Ltd., India) and average pressure (kg/cm 2 ) applied for crushing tablet was determined. Friability was determined by weighing 20 tablets after dusting and placing them in a roche friabilator (Electro lab ET-2, India), which was rotated for 100 revolutions. After dusting, total remaining mass of tablets was recorded and friability% was calculated.

4 DESHPANDE et al: DESIGN OF POLYPILL FOR TYPE -II DIABETES MELLITUS 559 Table 3 Result of evaluation of Metformin Hydrochloride Atorvastatin Calcium bulk powder Material Bulk Tapped Carr s Hausner Angle of density density index ratio repose g/ml g/ml % Metformin hydrochloride Atorvastatincalcium Table 4 Evaluation of Metformin HCl granules and Atorvastatin calcium granules S. No Formulation Bulkdensity Tappeddensity Carr sindex Hausner Angle of Code * g/ml g/ml % ratio repose Evaluation of Metformin HCl granules 1 SR SR SR SR SR SR SR Evaluation of Atorvastatin calcium granules 8 FR FR FR FR FR Thickness (mm) was determined by digital vernier caliper (Mitutoyo corp., Japan). In vitro Dissolution Studies Release of MH was determined using a dissolution apparatus type I of USP (Basket) at 100 rpm. Dissolution was studied at 37 ± 0.5ºC using 900 ml of phosphate buffer (ph 6.8). Samples (5 ml) were withdrawn at different intervals (1, 4 and 8 h) and filtered through 0.45 micro membrane filter. Filtrate was collected after discarding first few ml of filtrate. Sample solutions were analyzed by high performance liquid chromatography (HPLC) using following chromatographic conditions: column, C18 (250 X 4.6m), 5 µ; flow rate, 1.0 ml/min; UV detector, 225 nm; mobile phase, filtered and degassed mixture of buffer and acetonitrile (700: 300); and buffer, dissolved sodium dihydrogen phosphate (3.9 g) in 1000 ml purified water. ph6 was adjusted with dilute sodium hydroxide. Release of AC was determined using a dissolution apparatus type II of USP (Paddle) at 50 rpm. Dissolution was studied at 37 ± 0.5ºC using 0.1% sodium lauryl sulphate solution (1000 ml). Samples (5 ml) were withdrawn at 15 th, 30 th & 45 th min and filtered through 0.45 µ membrane filter. Filtrate was collected after discarding first few ml of filtrate. Sample solutions were analyzed by HPLC using UV detector under following chromatographic conditions: column, C8 (250 mm x 4.6 mm) 5µ SS column; wavelength, 254 nm; flow rate, 1.0 ml/min; mobile phase, filtered and degassed mixture of buffer and acetonitrile (400: 600) and adjusted ph 2.5 with Trifluoro acetic acid solution; and buffer, dissolved sodium dihydrogen phosphate (13.8 g) in 1000 ml water. Release data obtained were treated according to zero-order (cumulative amount of drug release vs time), first-order (log cumulative% drug remaining vs time), Higuchi (cumulative% release vs time) and Korsmeyer- Peppas (log cumulative% drug release vs log time) equation models. Stability Studies Promising formulation was tested for 3 months at 25ºC and 40ºC with 60% RH and 75% RH. At the interval of 15 days, tablets were withdrawn and evaluated for thickness, hardness, friability, weight variation, content uniformity, in vitro drug release and assay.

5 560 J SCI IND RES VOL 71 AUGUST 2012 a) b) Fig. 2 Drug release (%) profile of: a) Metformin Hydrochloride (MH) tablet matrices; and b) Atorvastatin Calcium (AC) tablet matrices Log % drug remaning Amount of drug release Drug release, % Drug release, % logmt/m Cumulative % drug release Fig. 3 First order kinetics, Higuchi model, Zero order kinetics and Peppas model of formulation F-7 Results and Discussion MH and AC were used as a model drugs for treatment of type-2 diabetes mellitus with associated dyslipidemia. Preformulation studies of MH and AC were evaluated for various physical properties individually (Table 3) and flow was found poor in the case of both drugs. In drug excipients compatibility studies, there was no incompatibility in drugs alone or with excipients. Bulk densities for granules of optimized formulation (Table 4) indicated good packing character. Compressibility index

6 DESHPANDE et al: DESIGN OF POLYPILL FOR TYPE -II DIABETES MELLITUS 561 (CI) for optimized formulation was found to be below 13%, indicating good flow properties. Flow properties of granules were further analyzed by determining angle of repose for all granules and it was below 30º for optimized formulation. Hausner s ratio for all granules formulated was less than 2%. By in vitro release study, SR7 and FD5 were considered to be optimized one (Fig. 2). Drug release rate in SR decreases as the concentration of sodium CMC, HPMC K4M and HPMC 15 Cps polymer increases. Thus concentration of polymers was predominant controlling factor. Good dissolution profile of SR7 might be due to HPMC 15 Cps as it is used as channeling agent, were liquid penetration into the matrix is the rate-limiting step. All batches of tablets were manufactured under similar conditions to avoid processing variables. Different parameters of bilayer tablets were: mass, 1120 ± 3.09 mg; hardness, 9 ± 0.89 kg/cm 2 ; thickness, 6.92 ± 0.6 mm; and friability of all formulations, 0.14 ± 0.2%. Hardness and friability of prepared bilayer tablets indicated good handling properties. Drug content uniformity in bilayer matrix tablets was 98.9 ± 0.39% for AC. Drug Release Study In vitro release study data (Fig. 3) indicated that the best fit model in all the cases was First order release for optimized formulation SR7 (0.9987; K value, ). Thus release of drug from dosage form was found to be dose dependent. First order release was found to be. Stability Studies No significant changes were observed in physical appearance, color, hardness, IR spectroscopy of bilayer tablet and dissolution studies of SR layer. Drug content% at different temperature after 2 weeks and 4 weeks was found to be within limits. From the data obtained (not shown), formulation was found to be stable under the conditions mentioned. Conclusions Bilayer tablets of MH and AC using hydrophilic swellable polymers HPMC and Sodium CMC as sustaining layer and croscarmellose sodium and polysorbate-80 for IR layer by wet granulation method were found to be good without chipping, capping and sticking. Granules of MH SR layer were prepared by using different viscosity of HPMC (15 Cps and 4000 Cps) and Sodium CMC as retarding agent. Granules of AC IR layer were prepared by using super disintegrants, croscarmellose sodium and polysorbate-80 as surfactant. Drug polymer ratios were found to influence the release of drug from SR layer of formulation. As the amount of polymer increases, drug release was found to decrease. In case of IR layer, as the concentration of surfactant was increased, drug release was also found to be increased. Drug release from optimized formulation SR7 was found to follow First order release kinetics. Thus release of drug from dosage form was found to be dose dependent. Formulation SR7 containing Sodium CMC (23.66% w/w), HPMC 15 Cps (1.18% w/w) and HPMC K4M (7.1% w/w) in following ratios releases the drug at desired rate. One month short term stability studies performed for optimized formulation at 25ºC and 40ºC with 60% RH and 75% RH indicated no appreciable changes in drug content% and in-vitro drug release studies. References 1 Ohmura C, Tanaka Y, Mitsuhashi N et al, Efficacy of low-dose metformin in japanese patients with type 2 diabetes mellitus, Curr Therap Res, 59 (1998) Streubel A, Siepmann J, Peppas N. A & Bodmeier R. Bimodal drug release achieved with multi-layer matrix tablets: transport mechanisms and device design, J Control Release, 69 (2000) Yoshino G, Hirano T & Kazumi T, Dyslipidemia in diabetes mellitus, Diabetes Res Clin Prac, 33 (1996) Erkelens D W, Insulin resistance syndrome and type 2 diabetes mellitus, Am J Cardiol, 88 (2001) 38J-42J. 5 Tousoulis D, Koniari K, Antoniades C et al, Impact of 6 weeks of treatment with low-dose Metformin and Atorvastatin on glucose-induced changes of endothelial function in adults with newly diagnosed type 2 diabetes mellitus: a single-blind study, Clin Ther, 32 (2010) Tousoulis D, Koniari K, Antoniades C et al, Combined effects of atorvastatin and metformin on glucose-induced variations of inflammatory process in patients with diabetes mellitus, Int J Cardiol, 149 (2011) Raza J F & Movahed A, Current concepts of cardiovascular diseases in diabetes mellitus, Int J Cardiol, 89 (2003) Kadu P J, Kushare S S, Thacker D D & Gattani S G. Enhancement of oral bioavailability of atorvastatin calcium by self-emulsifying drug delivery systems (SEDDS), Pharm Dev Technol, 16 (2011)

FORMULATION AND DEVELOPMENT OF ER METOPROLAOL SUCCINATE TABLETS

FORMULATION AND DEVELOPMENT OF ER METOPROLAOL SUCCINATE TABLETS International Journal of PharmTech Research CODEN( USA): IJPRIF ISSN : 0974-4304 Vol.1, No.3, pp 634-638, July-Sept 2009 FORMULATION AND DEVELOPMENT OF ER METOPROLAOL SUCCINATE TABLETS K. Reeta Vijaya

More information

A Comparative Evaluation of Cross Linked Starch Urea-A New Polymer and Other Known Polymers for Controlled Release of Diclofenac

A Comparative Evaluation of Cross Linked Starch Urea-A New Polymer and Other Known Polymers for Controlled Release of Diclofenac Asian Journal of Chemistry Vol. 22, No. 6 (2010), 4239-4244 A Comparative Evaluation of Cross Linked Starch Urea-A New Polymer and Other Known Polymers for Controlled Release of Diclofenac K.P.R. CHOWDARY*

More information

Sivakasi , Tamil Nadu, India. ABSTRACT KEYWORDS:

Sivakasi , Tamil Nadu, India. ABSTRACT KEYWORDS: 276 P a g e International Standard Serial Number (ISSN): 2319-8141 International Journal of Universal Pharmacy and Bio Sciences 4(1): January-February 2015 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY AND

More information

STABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS

STABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS Int. J. Chem. Sci.: 8(1), 2010, 405-414 STABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS V. L. NARASAIAH, T. KARTHIK KUMAR, D. SRINIVAS, K. SOWMYA, P. L. PRAVALLIKA and Sk. Md. MOBEEN

More information

Formulation and Evaluation

Formulation and Evaluation Chapter-5 Formulation and Evaluation 5.1 OBJECTIVE After successful taste masking and solubility enhancement of drugs in preliminary studies, by using Mannitol Solid Dispersion, next step includes the

More information

Venkateswara Rao et.al Indian Journal of Research in Pharmacy and Biotechnology ISSN: (Print) ISSN: (Online)

Venkateswara Rao et.al Indian Journal of Research in Pharmacy and Biotechnology ISSN: (Print) ISSN: (Online) Design and development of Metformin hydrochloride Tried sustained release tablets Venkateswara Rao T 1 *, Bhadramma N 1, Raghukiran CVS 2 and Madubabu K 3 Bapatla College of Pharmacy, Bapatla, Guntur-522101

More information

FORMULATION AND EVALUATION OF PIROXICAM AND CELECOXIB TABLETS EMPLOYING PROSOLVE BY DIRECT COMPRESSION METHOD

FORMULATION AND EVALUATION OF PIROXICAM AND CELECOXIB TABLETS EMPLOYING PROSOLVE BY DIRECT COMPRESSION METHOD Int. J. Chem. Sci.: 6(3), 2008, 1270-1275 FORMULATION AND EVALUATION OF PIROXICAM AND CELECOXIB TABLETS EMPLOYING PROSOLVE BY DIRECT COMPRESSION METHOD K. P. R. CHOWDARY, P. TRIPURA SUNDARI and K. SURYA

More information

DEVELOPMENT AND IN VITRO EVALUATION OF SUSTAINED RELEASE FLOATING MATRIX TABLETS OF METFORMIN HYDROCHLORIDE

DEVELOPMENT AND IN VITRO EVALUATION OF SUSTAINED RELEASE FLOATING MATRIX TABLETS OF METFORMIN HYDROCHLORIDE ISSN: 0975-8232 IJPSR (2010), Vol. 1, Issue 8 (Research article) Received 11 April, 2010; received in revised form 17 June, 2010; accepted 13 July, 2010 DEVELOPMENT AND IN VITRO EVALUATION OF SUSTAINED

More information

Formulation and Development of Sustained Release Tablets of Valsartan Sodium

Formulation and Development of Sustained Release Tablets of Valsartan Sodium INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACY, BIOLOGY AND CHEMISTRY Research Article Formulation and Development of Sustained Release Tablets of Valsartan Sodium G. Sandeep * and A. Navya Department of

More information

Maisammaguda, Dulapally, Secundrabad.

Maisammaguda, Dulapally, Secundrabad. 121 P a g e International Standard Serial Number (ISSN): 2319-8141 International Journal of Universal Pharmacy and Bio Sciences 3(6): November-December 2014 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY

More information

Formulation and evaluation of sublingual tablets of lisinopril

Formulation and evaluation of sublingual tablets of lisinopril Journal of GROVER Scientific & Industrial AGARWAL: Research FORMULATION AND EVALUATION OF SUBLINGUAL TABLETS OF LISINOPRIL Vol. 71, June 2012, pp. 413-417 413 Formulation and evaluation of sublingual tablets

More information

FORMULATION AND EVALUATION OF ACECLOFENAC SODIUM BILAYER SUSTAINED RELEASE TABLETS

FORMULATION AND EVALUATION OF ACECLOFENAC SODIUM BILAYER SUSTAINED RELEASE TABLETS International Journal of ChemTech Research CODEN( USA): IJCRGG ISSN : 0974-4290 Vol.1, No.4, pp 1381-1385, Oct-Dec 2009 FORMULATION AND EVALUATION OF ACECLOFENAC SODIUM BILAYER SUSTAINED RELEASE TABLETS

More information

DESIGN AND EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF FLURBIPROFEN

DESIGN AND EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF FLURBIPROFEN Int. J. Chem. Sci.: 10(4), 2012, 2199-2208 ISSN 0972-768X www.sadgurupublications.com DESIGN AND EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF FLURBIPROFEN K. V. R. N. S. RAMESH *, B. HEMA KIRNAMAYI

More information

Formulation and evaluation of immediate release salbutamol sulphate

Formulation and evaluation of immediate release salbutamol sulphate 5 Formulation, optimization and evaluation of immediate release layer of salbutamol sulphate Salbutamol is moderately selective beta (2)-receptor agonist similar in structure to terbutaline and widely

More information

FORMULATION AND EVALUATION OF BILAYERED TABLET OF METFORMIN HYDROCHLORIDE AND PIOGLITAZONE HYDROCHLORIDE

FORMULATION AND EVALUATION OF BILAYERED TABLET OF METFORMIN HYDROCHLORIDE AND PIOGLITAZONE HYDROCHLORIDE Academic Sciences International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 975-1491 Vol 4, Suppl 5, 212 FORMULATION AND EVALUATION OF BILAYERED TABLET OF METFORMIN HYDROCHLORIDE AND PIOGLITAZONE

More information

Formulation Development and Evaluation of Modified Release Tablet using a Fixed Dose Combination of Antidiabetic Agents

Formulation Development and Evaluation of Modified Release Tablet using a Fixed Dose Combination of Antidiabetic Agents Research Article Formulation Development and Evaluation of Modified Release Tablet using a Fixed Dose Combination of Antidiabetic Agents Nishit Gohel 1*, D M Patel 2, Komal Patel 3, Jignasa Modi 4 1 School

More information

FORMULATION AND EVALUATION OF VALSARTAN TABLETS EMPLOYING CYCLODEXTRIN-POLOXAMER 407-PVP K30 INCLUSION COMPLEXES

FORMULATION AND EVALUATION OF VALSARTAN TABLETS EMPLOYING CYCLODEXTRIN-POLOXAMER 407-PVP K30 INCLUSION COMPLEXES Int. J. Chem. Sci.: 10(1), 2012, 297-305 ISSN 0972-768X www.sadgurupublications.com FORMULATION AND EVALUATION OF VALSARTAN TABLETS EMPLOYING CYCLODEXTRIN-POLOXAMER 407-PVP K30 INCLUSION COMPLEXES K. P.

More information

Volume: 2: Issue-3: July-Sept ISSN FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL

Volume: 2: Issue-3: July-Sept ISSN FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL Volume: 2: Issue-3: July-Sept -2011 ISSN 0976-4550 FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL Ajaykumar Patil*, Ashish Pohane, Ramya Darbar, Sharanya Koutika, Alekhya

More information

Journal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp , Oct -Dec 2011

Journal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp , Oct -Dec 2011 ISSN: 223-7346 Research Article Journal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp -394-43, Oct -Dec 211 FORMULATION AND INVITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF GLIMEPIRIDE

More information

Design and In-vitro Evaluation of Silymarin Bilayer Tablets

Design and In-vitro Evaluation of Silymarin Bilayer Tablets CODEN (USA)-IJPRUR, e-issn: 2348-6465 International Journal of Pharma Research and Health Sciences Available online at www.pharmahealthsciences.net Original Article Design and In-vitro Evaluation of Silymarin

More information

Journal of Chemical and Pharmaceutical Research

Journal of Chemical and Pharmaceutical Research Available on line www.jocpr.com Journal of Chemical and Pharmaceutical Research ISSN No: 0975-7384 CODEN(USA): JCPRC5 J. Chem. Pharm. Res., 2011, 3(3):159-164 Studies on formulation and in vitro evaluation

More information

FORMULATION AND EVALUATION OF BILAYERED TABLET OF METFORMIN HYDROCHLORIDE AND GLIMEPIRIDE

FORMULATION AND EVALUATION OF BILAYERED TABLET OF METFORMIN HYDROCHLORIDE AND GLIMEPIRIDE Research Article Ghanshyam Patel,, 2012; Volume 1(6): 75-87 ISSN: 2277-8713 FORMULATION AND EVALUATION OF BILAYERED TABLET OF METFORMIN HYDROCHLORIDE AND GLIMEPIRIDE -QR CODE GHANSHYAM PATEL 1, Dr. RAGIN

More information

STUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS

STUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS Int. J. Chem. Sci.: 10(4), 2012, 1934-1942 ISSN 0972-768X www.sadgurupublications.com STUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS K. VENUGOPAL * and K. P. R. CHOWDARY a Nirmala College

More information

OPTIMIZATION OF CONTROLLED RELEASE GASTRORETENTIVE BUOYANT TABLET WITH XANTHAN GUM AND POLYOX WSR 1105

OPTIMIZATION OF CONTROLLED RELEASE GASTRORETENTIVE BUOYANT TABLET WITH XANTHAN GUM AND POLYOX WSR 1105 Digest Journal of Nanomaterials and Biostructures Vol. 9, No. 3, July September 2014, p. 1077-1084 OPTIMIZATION OF CONTROLLED RELEASE GASTRORETENTIVE BUOYANT TABLET WITH XANTHAN GUM AND POLYOX WSR 1105

More information

PREPARATION AND INVITRO EVALUATION OF RABEPRAZOLE SODIUM DELAYED RELEASE ENTERIC COATED TABLETS

PREPARATION AND INVITRO EVALUATION OF RABEPRAZOLE SODIUM DELAYED RELEASE ENTERIC COATED TABLETS Page1000 Indo American Journal of Pharmaceutical Research, 2014 ISSN NO: 2231-6876 Journal home page: http:///index.php/en/ INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH PREPARATION AND INVITRO EVALUATION

More information

Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast Sodium

Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast Sodium Available online on www.ijddt.com International Journal of Drug Delivery Technology 214; (3); 98-13 Research Article ISSN: 97 441 Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast

More information

Journal of Global Trends in Pharmaceutical Sciences. Journal home page:

Journal of Global Trends in Pharmaceutical Sciences. Journal home page: ISSN: 2230-7346 G Sridhar Babu et al. / JGTPS/ 5(4)-(2014) 2085-2092 (Research Article) Journal of Global Trends in Pharmaceutical Sciences Journal home page: www.jgtps.com FORMULATION AND IN-VITRO CHARACTERIZATION

More information

FABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS

FABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS Int. J. Chem. Sci.: 7(4), 2009, 2555-2560 FABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS HINDUSTAN ABDUL AHAD *, B. PRADEEP KUMAR, C.

More information

May Vol: 06 Issue: 01 (1-12)

May Vol: 06 Issue: 01 (1-12) May 16 Vol: 6 Issue: 1 (1-1) RESEARCH PAPER Formulation and Evaluation of Extended Release Tablets of Metformin HCl Anamika Chouhan*1, Deepak Marothia1, Khushboo Ranka1, Kamal Singh Rathore 1Department

More information

Available Online through Research Article

Available Online through Research Article ISSN: 0975-766X Available Online through Research Article www.ijptonline.com DESIGN AND EVALUATION OF GASTRORETENTIVE TABLETS FOR CONTROLLED DELIVERY OF NORFLOXOCIN Ganesh Kumar Gudas*, Subal Debnath,

More information

Int. Res J Pharm. App Sci., 2014; 4(1):47-51 ISSN:

Int. Res J Pharm. App Sci., 2014; 4(1):47-51 ISSN: International Research Journal of Pharmaceutical and Applied Sciences (IRJPAS) Available online at www.irjpas.com Int. Res J Pharm. App Sci., 2014; 4(1):47-51 Research Article FORMULATION AND EVALUATION

More information

Formulation and In vitro Release Characterization of Metoprolol Succinate Extended Release Tablets

Formulation and In vitro Release Characterization of Metoprolol Succinate Extended Release Tablets Sakthikumar et al: Formulation and In vitro Release Characterization of Metoprolol Succinate Extended Release Tablets 1537 International Journal of Pharmaceutical Sciences and Nanotechnology Volume 4 Issue

More information

INTERNATIONAL RESEARCH JOURNAL OF PHARMACY

INTERNATIONAL RESEARCH JOURNAL OF PHARMACY INTERNATIONAL RESEARCH JOURNAL OF PHARMACY www.irjponline.com ISSN 2230 8407 Research Article FORMULATION DEVELOPMENT AND EVALUATION OF IMMEDIATE RELEASE BILAYER TABLETS OF TELMISERTAN AND HYDROCHLOROTHIAZIDE

More information

Optimization of valsartan tablet formulation by 2 3 factorial design

Optimization of valsartan tablet formulation by 2 3 factorial design Research Article ISSN: 0974-6943 K. P. R. Chowdary et al. / Journal of Pharmacy Research 2014,8(9, Available online through http://jprsolutions.info Optimization of valsartan tablet formulation by 2 3

More information

Int. J. Pharm. Sci. Rev. Res., 28(1), September October 2014; Article No. 21, Pages:

Int. J. Pharm. Sci. Rev. Res., 28(1), September October 2014; Article No. 21, Pages: Research Article V.T. Iswariya 1 *, A Hariom Prakash Rao 1, V Lokeswara Babu 1, Mohd Abdul Hadi 1, A Srinivasa Rao 2 1 Dept. of Pharmaceutics, Bhaskar Pharmacy College, Bhaskar Nagar, Yenkapally (V), Moinabad

More information

Formulation Development and Evaluation of Bilayer Floating Tablet of Antidiabetic Drugs

Formulation Development and Evaluation of Bilayer Floating Tablet of Antidiabetic Drugs Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 0, 8 ():- (http://scholarsresearchlibrary.com/archive.html) ISSN 097-07 USA CODEN: DPLEB Formulation

More information

Formulation and evaluation of inlay tablet of metformin hydrochloride as sustained release and pioglitazone with glibenclamide as immediate release

Formulation and evaluation of inlay tablet of metformin hydrochloride as sustained release and pioglitazone with glibenclamide as immediate release Research Article ISSN: 0974-6943 Available online through http://jprsolutions.info Formulation and evaluation of inlay tablet of metformin hydrochloride as sustained release and pioglitazone with glibenclamide

More information

Research Journal of Pharmaceutical, Biological and Chemical Sciences

Research Journal of Pharmaceutical, Biological and Chemical Sciences Research Journal of Pharmaceutical, Biological and Chemical Sciences Formulation And Invitro Evaluation Of Sustained Release Matrix Tablets Of Ibuprofen S Shanmugam, T Vetrichelvan and P Niranjan* Adhiparasakthi

More information

Preparation and Evaluation of Gastro Retentive Floating Tablets of Atorvastatin Calcium

Preparation and Evaluation of Gastro Retentive Floating Tablets of Atorvastatin Calcium Preparation and Evaluation of Gastro Retentive Floating Tablets of Atorvastatin Calcium Florida Sharmin 1, Md. Abdullah Al Masum 1, S. M. Ashraful Islam 1 and Md. Selim Reza 2 1 Department of Pharmacy,

More information

MODULATION OF GASTROINTESTINAL TRANSIT TIME OF SALBUTAMOL SULPHATE BY FLOATING APPROCHES

MODULATION OF GASTROINTESTINAL TRANSIT TIME OF SALBUTAMOL SULPHATE BY FLOATING APPROCHES Pooja et al Journal of Drug Delivery & Therapeutics; 213, 3(3), 37-41 37 Available online at http://jddtonline.info RESEARCH ARTICLE MODULATION OF GASTROINTESTINAL TRANSIT TIME OF SALBUTAMOL SULPHATE BY

More information

Formulation and Evaluation of Indomethacin Bilayer Sustained Release Tablets

Formulation and Evaluation of Indomethacin Bilayer Sustained Release Tablets International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 0974-4304 Vol. 3, No.2, pp 1132-1138, April-June 2011 Formulation and Evaluation of Indomethacin Bilayer Sustained Release Tablets

More information

Karnataka Department of Pharmaceutical Technology, H.K.E. Society s College of Pharmacy, Gulbarga, Karnataka ABSTRACT KEYWORDS:

Karnataka Department of Pharmaceutical Technology, H.K.E. Society s College of Pharmacy, Gulbarga, Karnataka ABSTRACT KEYWORDS: 335 P a g e International Standard Serial Number (ISSN): 2319-8141 International Journal of Universal Pharmacy and Bio Sciences 4(6): November-December 2015 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY

More information

The Relevance of USP Methodology in the Development of a Verapamil Hydrochloride (240 mg) Extended Release Formulation

The Relevance of USP Methodology in the Development of a Verapamil Hydrochloride (240 mg) Extended Release Formulation METHOCEL Premium Cellulose Ethers Application Data The Relevance of USP Methodology in the Development of a Verapamil Hydrochloride (240 mg) Extended Release Formulation INTRODUCTION Hydrophilic matrices

More information

DEVELOPMENT AND EVALUATION OF A DIRECTLY COMPRESSIBLE CO PROCESSED MULTIFUNCTION SUSTAINED RELEASE AGENT FOR TABLETS

DEVELOPMENT AND EVALUATION OF A DIRECTLY COMPRESSIBLE CO PROCESSED MULTIFUNCTION SUSTAINED RELEASE AGENT FOR TABLETS International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 975-1491 Vol 2, Suppl 4, 1 Research Article DEVELOPMENT AND EVALUATION OF A DIRECTLY COMPRESSIBLE CO PROCESSED MULTIFUNCTION SUSTAINED

More information

Asian Journal of Biochemical and Pharmaceutical Research

Asian Journal of Biochemical and Pharmaceutical Research ISSN: 2231-2560 Research Article Asian Journal of Biochemical and Pharmaceutical Research Design and Evaluation of Gastroretentive Floating Tablets of Dipyridamole: Influence of Formulation Variables A.

More information

FORMULATION DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF BILAYER TABLETS OF AMOXICILLIN AND FAMOTIDINE

FORMULATION DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF BILAYER TABLETS OF AMOXICILLIN AND FAMOTIDINE ISSN: 2395 1338 FORMULATION DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF BILAYER TABLETS OF AMOXICILLIN AND FAMOTIDINE B. Venkateswara Reddy *, K. Navaneetha Department of Pharmaceutics, St.Paul s College

More information

FORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE COLON TARGETED TABLETS

FORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE COLON TARGETED TABLETS INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article FORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE COLON TARGETED TABLETS G. Subba Rao

More information

Preparation and Evaluation of Silymarin Controlled Release Tablets Prepared Using Natural Gums

Preparation and Evaluation of Silymarin Controlled Release Tablets Prepared Using Natural Gums 1368 International Journal of Pharmaceutical Sciences and Nanotechnology Volume 4 Issue 1 April-June 211 Research Paper International Journal of Pharmaceutical Sciences and Nanotechnology Volume 4 Issue

More information

Journal of Chemical and Pharmaceutical Research

Journal of Chemical and Pharmaceutical Research Available on line www.jocpr.com Journal of Chemical and Pharmaceutical Research J. Chem. Pharm. Res., 2010, 2(5):534-540 ISSN No: 0975-7384 CODEN(USA): JCPRC5 Formulation and evaluation of Valsartan film

More information

J.Ayyappan et al, /J. Pharm. Sci. & Res. Vol.2 (7), 2010,

J.Ayyappan et al, /J. Pharm. Sci. & Res. Vol.2 (7), 2010, Development and Evaluation of a Directly Compressible Co-processed Multifunction Sustained Release Agent for Gliclazide Sustained Release Tablets J. Ayyappan* 1, P.Umapathi 1, Darlin Quine 2 1 Department

More information

Formulation and Optimization of Immediate Release Tablet of Sitagliptin Phosphate using Response Surface Methodology

Formulation and Optimization of Immediate Release Tablet of Sitagliptin Phosphate using Response Surface Methodology Formulation and Optimization of Immediate Release Tablet of Sitagliptin Phosphate using Response Surface Methodology Sunita Shakya Department of Pharmacy, Kathmandu University, Kavre, Nepal. Email: sunita95@gmail.com

More information

Formulation and evaluation of oro-dispersible tablets of lafutidine

Formulation and evaluation of oro-dispersible tablets of lafutidine Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2015, 7 (5):226-235 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4

More information

Formulation development of Glipizide matrix tablet using different proportion of natural and semi synthetic polymers

Formulation development of Glipizide matrix tablet using different proportion of natural and semi synthetic polymers Pharm Methods, 2017; 8(1): 45-53 A multifaceted peer reviewed journal in the field of Pharm Analysis and Pharmaceutics www.phmethods.net www.journalonweb.com/phm Research Article Formulation development

More information

Asian Journal of Pharmacy and Life Science ISSN Vol. 2 (2), July-Sept,2012

Asian Journal of Pharmacy and Life Science ISSN Vol. 2 (2), July-Sept,2012 STUDIES ON EFFECT OF SUPERDISINTEGRANTS ON ETORICOXIB TABLET FORMULATIONS Chowdary K. P. R 1, Venugopal. K *2 1 College of Pharmaceutical Sciences, Andhra University, Vishakapattanam. 2 * Nirmala college

More information

Asian Journal of Research in Biological and Pharmaceutical Sciences

Asian Journal of Research in Biological and Pharmaceutical Sciences Research Article ISSN: 2349 4492 Asian Journal of Research in Biological and Pharmaceutical Sciences Journal home page: www.ajrbps.com APPLICATION OF FACTORIAL DESIGN AND OPTIMIZATION OF GLIMEPIRIDE SUSTAINED

More information

Formulation and Evaluation of Bilayer Tablets of Glimepiride and Metformin HCL

Formulation and Evaluation of Bilayer Tablets of Glimepiride and Metformin HCL IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-issn: 2278-38, p-issn:2319-7676. Volume 9, Issue 1 Ver. IV (Jan. 214), PP 38-45 Formulation and Evaluation of Bilayer Tablets of Glimepiride

More information

FORMULATION AND EVALUATION OF FLOATING TABLETS OF NORFLOXACIN

FORMULATION AND EVALUATION OF FLOATING TABLETS OF NORFLOXACIN FORMULATION AND EVALUATION OF FLOATING TABLETS OF NORFLOXACIN Ms. Jyoti Rathore 1*, Mr. Hitesh Kumar Parmar 1 Ujjain Institute of Pharmaceutical Sciences, Ujjain. Email- hkparmar7@rediffmail.com ABSTRACT

More information

Effect of Polymer Concentration and Viscosity Grade on Atenolol Release from Gastric Floating Drug Delivery Systems

Effect of Polymer Concentration and Viscosity Grade on Atenolol Release from Gastric Floating Drug Delivery Systems Effect of Polymer Concentration and Viscosity Grade on Atenolol Release from Gastric Floating Drug Delivery Systems 1 1 1 2 U.V. Bhosale*, V. Kusum Devi, Nimisha Jain and P.V. Swamy 1 Al-Ameen College

More information

FORMULATION AND EVALUATIONOF AMOXYCILLIN: THREE-LAYER GUAR GUM MATRIX TABLET

FORMULATION AND EVALUATIONOF AMOXYCILLIN: THREE-LAYER GUAR GUM MATRIX TABLET Gupta and Singh, IJPSR, 2013; Vol. 4(7): 2683-2690. ISSN: 0975-8232 IJPSR (2013), Vol. 4, Issue 7 (Research Article) Received on 05 March, 2013; received in revised form, 29 April, 2013; accepted, 29 June,

More information

Reddy Sunil, Panakanti Pavan kumar, Kandagatla Rajanarayana and Yamsani Madhusudan Rao*

Reddy Sunil, Panakanti Pavan kumar, Kandagatla Rajanarayana and Yamsani Madhusudan Rao* International Journal of Pharmaceutical Sciences and Nanotechnology Volume 3 Issue 1 April June 2010 Research Paper Formulation and Release Characteristic of a Bilayer Matrix Tablet Containing Glimepride

More information

Formulation And Evaluation Of Flurbiprofen Matrix Tablets For Colon Targeting

Formulation And Evaluation Of Flurbiprofen Matrix Tablets For Colon Targeting Formulation And Evaluation Of Flurbiprofen Matrix Tablets For Colon Targeting Biresh Kumar Sarkar* 1, Devananda Jain 1, Mamta Parwal 2 1. Bhagwant University, Dept.of Pharmaceutical Tech and Sciences,

More information

FORMULATION AND IN VITRO EVALUATION OF FAMOTIDINE FLOATING TABLETS BY LIPID SOLID DISPERSION SPRAY DRYING TECHNIQUE

FORMULATION AND IN VITRO EVALUATION OF FAMOTIDINE FLOATING TABLETS BY LIPID SOLID DISPERSION SPRAY DRYING TECHNIQUE INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article FORMULATION AND IN VITRO EVALUATION OF FAMOTIDINE FLOATING TABLETS BY LIPID SOLID DISPERSION

More information

PREPARATION AND EVALUATION OF STARCH - PEG 1500 CO-PROCESSED EXCIPIENT AS A NEW DIRECTLY COMPRESSIBLE VEHICLE IN TABLET FORMULATIONS

PREPARATION AND EVALUATION OF STARCH - PEG 1500 CO-PROCESSED EXCIPIENT AS A NEW DIRECTLY COMPRESSIBLE VEHICLE IN TABLET FORMULATIONS INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article PREPARATION AND EVALUATION OF STARCH - PEG 1500 CO-PROCESSED EXCIPIENT AS A NEW DIRECTLY COMPRESSIBLE

More information

Design and Characterization of Valsartan Loaded Press Coated Pulsatile Tablets

Design and Characterization of Valsartan Loaded Press Coated Pulsatile Tablets Research Reviews: Pharmacy & Pharmaceutical Sciences e-issn: 2320-1215 www.rroij.com Design and Characterization of Valsartan Loaded Press Coated Pulsatile Tablets Sowjanya Battu*, Madhavi K, Bhikshapathi

More information

Formulation and Evaluation of Metronidazole Enteric Coated Tablets for Colon Targeting

Formulation and Evaluation of Metronidazole Enteric Coated Tablets for Colon Targeting Human Journals Research Article May 2015 Vol.:3, Issue:2 All rights are reserved by Srilakshmi N et al. Formulation and Evaluation of Metronidazole Enteric Coated Tablets for Colon Targeting Keywords:

More information

Design and Evaluation of Atenolol Floating Drug Delivery System

Design and Evaluation of Atenolol Floating Drug Delivery System Available online on www.ijcpr.com International Journal of Current Pharmaceutical Review and Research, 4(1), 1-26 Research Article ISSN: 976-822X Design and Evaluation of Atenolol Floating Drug Delivery

More information

FORMULATION AND EVALUATION OF ETORICOXIB TABLETS EMPLOYING CYCLODEXTRIN- POLOXAMER PVPK30 INCLUSION COMPLEXES

FORMULATION AND EVALUATION OF ETORICOXIB TABLETS EMPLOYING CYCLODEXTRIN- POLOXAMER PVPK30 INCLUSION COMPLEXES Volume: 2: Issue-4: Oct - Dec -2011 ISSN 0976-4550 FORMULATION AND EVALUATION OF ETORICOXIB TABLETS EMPLOYING CYCLODEXTRIN- POLOXAMER 407 - PVPK30 INCLUSION COMPLEXES K.P.R. Chowdary*, K. Surya Prakasa

More information

Formulation and In-vitro Evaluation of Sumatriptan succinate Bilayer Tablets

Formulation and In-vitro Evaluation of Sumatriptan succinate Bilayer Tablets Formulation and In-vitro Evaluation of Sumatriptan succinate Bilayer Tablets M. Sunitha Reddy 1, B. Sharath Reddy 1, S. Muhammed Fazal Ul Haq 1 Centre of Pharmaceutical Sciences, Jawaharlal Nehru Technological

More information

Available online Research Article

Available online   Research Article Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 2014, 6(12):213-221 Research Article ISSN : 0975-7384 CODEN(USA) : JCPRC5 Formulation development and evaluation of metoprolol

More information

Formulation and Evaluation of Rosuvastatin Immediate Release Tablets 10 Mg

Formulation and Evaluation of Rosuvastatin Immediate Release Tablets 10 Mg IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-issn:2278-3008, p-issn:2319-7676. Volume 11, Issue 5 Ver. III (Sep. - Oct.2016), PP 01-05 www.iosrjournals.org Formulation and Evaluation

More information

Volume 12, Issue 1, January February 2012; Article-021. *Corresponding author s

Volume 12, Issue 1, January February 2012; Article-021. *Corresponding author s Research Article FORMULATION AND OPTIMIZATION OF POROUS OSMOTIC PUMP BASED CONTROLLED RELEASE SYSTEM OF RESIDRONATE SODIUM FOR THE TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS Chinmaya Keshari Sahoo* 1, Tanmaya

More information

INTERNATIONAL RESEARCH JOURNAL OF PHARMACY ISSN Research Article

INTERNATIONAL RESEARCH JOURNAL OF PHARMACY  ISSN Research Article INTERNATIONAL RESEARCH JOURNAL OF PHARMACY www.irjponline.com ISSN 2230 8407 Research Article FORMULATION AND EVALUATION OF BILAYERED FLOATING TABLETS OF METFORMIN HYDROCHLORIDE R.Margret Chandira*, P.Palanisamy,

More information

Study of Disintegrant Property of Moringa Oleifera Gum and its Comparison with other Superdisintegrants

Study of Disintegrant Property of Moringa Oleifera Gum and its Comparison with other Superdisintegrants International Journal of ChemTech Research CODEN( USA): IJCRGG ISSN : 0974-4290 Vol. 3, No.3, pp 1119-1124, July-Sept 2011 Study of Disintegrant Property of Moringa Oleifera Gum and its Comparison with

More information

Design and Development of combination therapy for treatment of Multiple sclerosis

Design and Development of combination therapy for treatment of Multiple sclerosis J Pharm Sci Bioscientific Res. 217. 7(2):181-186 ISSN NO. 2271-3681 Design and Development of combination therapy for treatment of Multiple sclerosis Priyaranjan Pattanaik, Kanu R. Patel 1. Research Scholar,

More information

Patel Krunal M et al. IRJP 2 (2)

Patel Krunal M et al. IRJP 2 (2) INTERNATIONAL RESEARCH JOURNAL OF PHARMACY ISSN 223 87 Available online http://www.irjponline.com Research Article DESIGN DEVELOPMENT AND EVALUATION OF MODIFIED RELEASE TABLET OF MONTELUKAST SODIUM BY

More information

DISSOLUTION ENHANCEMENT OF CARVEDILOL BY USING SURFACTANT AS A COATING MATERIAL

DISSOLUTION ENHANCEMENT OF CARVEDILOL BY USING SURFACTANT AS A COATING MATERIAL Research Article DISSOLUTION ENHANCEMENT OF CARVEDILOL BY USING SURFACTANT AS A COATING MATERIAL VINAYAK D. KADAM, SURENDRA G.GATTANI, Department of Pharmaceutics, R.C. Patel Institute of Ph Education

More information

International Journal of Medicine and Pharmaceutical Research

International Journal of Medicine and Pharmaceutical Research International Journal of Medicine and Pharmaceutical Research Journal Home Page: www.pharmaresearchlibrary.com/ijmpr Research Article Open Access Formulation and Evaluation of Gastroretentive Floating

More information

International Journal of Pharmacy and Industrial Research

International Journal of Pharmacy and Industrial Research 164 Original Article ISSN Print Online International Journal Pharmacy Industrial Research 2231 3648 2231 366 A VALID ADVANCE TECHNIQUE DESIGNED FOR GLIBENCLAMIDE AND METFORMIN HCL INTO IMMEDIATE AND EXTENDED

More information

Formulation and Evaluation of Saxagliptin Immediate Release and METFORMIN Hydrochloride Sustained Release Tablet

Formulation and Evaluation of Saxagliptin Immediate Release and METFORMIN Hydrochloride Sustained Release Tablet 36 International Journal of Health Sciences, Vol. 1 No. 1, December 2013 Formulation and Evaluation of Saxagliptin Immediate Release and METFORMIN Hydrochloride Sustained Release Tablet R. Margret Chandira

More information

Int. Res J Pharm. App Sci., 2013; 3(6):42-46 ISSN:

Int. Res J Pharm. App Sci., 2013; 3(6):42-46 ISSN: International Research Journal of Pharmaceutical and Applied Sciences (IRJPAS) Available online at www.irjpas.com Int. Res J Pharm. App Sci., 2013; 3(6):42-46 Research Article ENHANCEMENT OF SOLUBILITY

More information

Pavan K et al IJARPB: 2013, 3(2), ISSN: Available online on Research Article

Pavan K et al IJARPB: 2013, 3(2), ISSN: Available online on  Research Article Available online on www.ijarpb.com Research Article Received on 15/01/2013; Revised on 23/01/2013; Accepted on 27/01/2013; Fast Dissolving Tablets Of Pioglitazone Hydrochloride By Use Of Various Superdisintegrants

More information

Feasibility of using natural gums for development of sustained release matrix tablet of itopride

Feasibility of using natural gums for development of sustained release matrix tablet of itopride Available online at wwwscholarsresearchlibrarycom Scholars Research Library Der Pharmacia Lettre, 215, 7 (3):114-123 (http://scholarsresearchlibrarycom/archivehtml) ISSN 975-571 USA CODEN: DPLEB4 Feasibility

More information

Research Article. Formulation development and optimization of chirally pure S (+) Etodolac extended release tablets for the management of arthritis

Research Article. Formulation development and optimization of chirally pure S (+) Etodolac extended release tablets for the management of arthritis Available online www.jocpr.com Journal of Chemical and Pharmaceutical Research, 214, 6(9):16-166 Research Article ISSN : 975-7384 CODEN(USA) : JCPRC5 Formulation development and optimization of chirally

More information

Scholars Research Library. Formulation Development of Pioglitazone Tablets Employing β Cyclodextrin- Poloxamer 407- PVP K30: A Factorial Study

Scholars Research Library. Formulation Development of Pioglitazone Tablets Employing β Cyclodextrin- Poloxamer 407- PVP K30: A Factorial Study Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2011, 3 (6):24-30 (http:scholarsresearchlibrary.comarchive.html) ISSN 0974-248X USA CODEN: DPLEB4 Formulation

More information

INTERNATIONAL RESEARCH JOURNAL OF PHARMACY ISSN Research Article

INTERNATIONAL RESEARCH JOURNAL OF PHARMACY  ISSN Research Article INTERNATIONAL RESEARCH JOURNAL OF PHARMACY www.irjponline.com ISSN 2230 8407 Research Article FORMULATION AND EVALUATION OF PRAVASTATIN SODIUM IMMEDIATE RELEASE TABLETS Devanand Pinate 1 *, Ravikumar 1,

More information

Raman Tativaka et al. / Int. Res J Pharm. App Sci., 2012; 2(2): 5-15

Raman Tativaka et al. / Int. Res J Pharm. App Sci., 2012; 2(2): 5-15 International Research Journal of Pharmaceutical and Applied Sciences Available online at www.irjpas.com Int. Res J Pharm. App Sci., 2012; 2(2):5-15 IRJPAS ISSN-2277-4149 Research Article DEVELOPMENT AND

More information

7. SUMMARY, CONCLUSION AND RECOMMENDATIONS

7. SUMMARY, CONCLUSION AND RECOMMENDATIONS 211 7. SUMMARY, CONCLUSION AND RECOMMENDATIONS Drug absorption from the gastro intestinal tract can be limited by various factors with the most common one being poor aqueous solubility and poor permeability

More information

Development And Evaluation Of Gastroretentive Floating Tablet Of Rosuvastatin

Development And Evaluation Of Gastroretentive Floating Tablet Of Rosuvastatin Development And Evaluation Of Gastroretentive Floating Tablet Of Rosuvastatin Amiya kumar Prusty, Archana P. Chand Institute of Pharmacy and Technology, salipur, Biju Patnaik University of technology,

More information

Formulation and In-Vitro Evaluation of Leflunomide Tablet with Enhanced Dissolution

Formulation and In-Vitro Evaluation of Leflunomide Tablet with Enhanced Dissolution ISSN 2395-3411 Available online at www.ijpacr.com 486 Research Article Formulation and In-Vitro Evaluation of Leflunomide Tablet with Enhanced Dissolution Ghanshayma M. Patil*, Harshal K. Patil, Vipul

More information

Asian Journal of Research in Biological and Pharmaceutical Sciences Journal home page:

Asian Journal of Research in Biological and Pharmaceutical Sciences Journal home page: Research Article ISSN: 2349 4492 Asian Journal of Research in Biological and Pharmaceutical Sciences Journal home page: www.ajrbps.com DESIGN, DEVELOPMENT AND EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM

More information

DEVELOPMENT OF NON SODIUM EFFERVESCENT TABLET OF PARACETAMOL USING ARGININE CARBONATE

DEVELOPMENT OF NON SODIUM EFFERVESCENT TABLET OF PARACETAMOL USING ARGININE CARBONATE IJPSR (2013), Vol. 4, Issue 5 (Research Article) Received on 17 July, 2012; received in revised form, 23 February, 2013; accepted, 14 April, 2013 DEVELOPMENT OF NON SODIUM EFFERVESCENT TABLET OF PARACETAMOL

More information

Preparation and Evaluation of Ethyl Cellulose Coated Microcapsules of Carbamazepine for Controlled Release

Preparation and Evaluation of Ethyl Cellulose Coated Microcapsules of Carbamazepine for Controlled Release Asian Journal of Chemistry Vol. 20, No. 8 (2008), 5901-5907 Preparation and Evaluation of Ethyl Cellulose Coated Microcapsules of Carbamazepine for Controlled Release K.P.R. CHOWDARY* and MALLURU SUBBA

More information

Formulation Development and In-Vitro Evaluation of Gastroretentive Floating tablets of Atenolol

Formulation Development and In-Vitro Evaluation of Gastroretentive Floating tablets of Atenolol Formulation Development and In-Vitro Evaluation of Gastroretentive Floating tablets of Atenolol K.Viveksarathi, K.Kannan*, S.Selvamuthu Kumar, R.Manavalan Department of Pharmacy, Faculty of Engineering

More information

Formulation and evaluation of oral dispersible tablets of aripiprazole

Formulation and evaluation of oral dispersible tablets of aripiprazole IJPAR Vol.6 Issue 2 April - June -17 Journal Home page: ISSN:23-2831 Research article Open Access Formulation and evaluation of oral dispersible tablets of aripiprazole A.Madhusudhan Reddy*, P.Srinivasababu,

More information

DVA Symposium Mexico City Anisul Quadir Ph.D, MBA SE Tylose USA, Inc. (A Shin-Etsu Chemical Group Co.) Totowa, NJ

DVA Symposium Mexico City Anisul Quadir Ph.D, MBA SE Tylose USA, Inc. (A Shin-Etsu Chemical Group Co.) Totowa, NJ QbD Approach to Formulation of Hydrophilic Matrix Using Sample Kit of Hypromellose [Metolose SR] DVA Symposium Mexico City Anisul Quadir Ph.D, MBA SE Tylose USA, Inc. (A Shin-Etsu Chemical Group Co.) Totowa,

More information

International Journal of Chemistry and Pharmaceutical Sciences

International Journal of Chemistry and Pharmaceutical Sciences Ramesh Naik M et al IJCPS, 2014, Vol.2(11): 1259-1264 Research Article ISSN: 2321-3132 International Journal of Chemistry and Pharmaceutical Sciences Fabrication and Evaluation of Montelukastsodium Sustained

More information

International Journal of Innovative Pharmaceutical Sciences and Research

International Journal of Innovative Pharmaceutical Sciences and Research International Journal of Innovative Pharmaceutical Sciences and Research www.ijipsr.com FORMULATION AND EVALUATION OF ph INDEPENDENT TABLETS OF ATENOLOL 1 S. Mahaboob Basha*, 2 N. Srinivas Department of

More information

EVALUATION OF EFFERVESCENT FLOATING TABLETS. 6.7 Mathematical model fitting of obtained drug release data

EVALUATION OF EFFERVESCENT FLOATING TABLETS. 6.7 Mathematical model fitting of obtained drug release data EVALUATION OF EFFERVESCENT FLOATING TABLETS 6.1 Technological characteristics of floating tablets 6.2 Fourier transform infrared spectroscopy (FT-IR) 6.3 Differential scanning calorimetry (DSC) 6.4 In

More information

Formulation Development of Aceclofenac Tablets Employing Starch Phosphate -A New Modified Starch

Formulation Development of Aceclofenac Tablets Employing Starch Phosphate -A New Modified Starch Abstract K.P.R. Chowdary et al. / International Journal of Pharma Sciences and Research (IJPSR) Formulation Development of Aceclofenac Tablets Employing Starch Phosphate -A New Modified Starch K.P.R. Chowdary*,

More information

FORMULATION DEVELOPMENT AND EVALUATION OF FENOFIBRATE CAPSULES

FORMULATION DEVELOPMENT AND EVALUATION OF FENOFIBRATE CAPSULES FORMULATION DEVELOPMENT AND EVALUATION OF FENOFIBRATE CAPSULES Dissertation Submitted in partial fulfillment of the requirement for the award of the degree of MASTER OF PHARMACY IN PHARMACEUTICS of THE

More information