Adiponectin/leptin ratio and insulin resistance in pregnancy
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1 Research Note Adiponectin/leptin ratio and insulin resistance in pregnancy Journal of International Medical Research 41(1) ! The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalspermissions.nav DOI: / imr.sagepub.com A Skvarca, 1 M Tomazic, 1 R Blagus, 2 B Krhin 3 and A Janez 1 Abstract Objective: Pregnancy is characterized by progressive insulin resistance. The present study evaluated whether the adiponectin/leptin ratio is associated with insulin resistance in pregnancy, since this ratio has been shown to be associated with insulin resistance in obesity, type 2 diabetes mellitus, metabolic syndrome and polycystic ovary syndrome. Methods: In this cross-sectional study, adiponectin and leptin concentrations were measured in pregnant women using enzyme-linked immunosorbent assays. Insulin resistance was assessed using the homeostasis model assessment of insulin resistance (HOMA IR). Results: Mean SD age of the participants (n ¼ 74) was years, mean SD gestational age was weeks and median body mass index (BMI) before pregnancy was kg/m 2 (interquartile range kg/m 2 ). There was a significant correlation between the HOMA IR and leptin concentration, but not between the HOMA IR and adiponectin concentration. There was a significant inverse correlation between the HOMA IR and adiponectin/leptin ratio. The adiponectin/leptin ratio was inversely correlated with BMI before pregnancy. Conclusion: The adiponection/leptin ratio inversely correlates with HOMA IR in pregnancy. Keywords Adipocytokine, adiponectin, adiponectin/leptin ratio, gestation, insulin resistance, leptin, pregnancy Date received: 10 October 2012; accepted: 21 October 2012 Introduction Pregnancy is characterized by varying degrees of progressive insulin resistance. 1 The homeostasis model assessment of insulin resistance (HOMA IR) represents a 1 Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia 2 Institute for Biostatistics and Medical Informatics, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia simple and noninvasive method for estimating insulin resistance during 3 Department of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia Corresponding author: Dr Ales Skvarca, Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre Ljubljana, Zaloska 7, SI-1000 Ljubljana, Slovenia. ales.skvarca@kclj.si
2 Journal of International Medical Research 41(1) 124 pregnancy, using fasting glucose and insulin concentrations. 2 Adiponectin and leptin are two adipocyokines that have been shown to be associated with insulin resistance. 3,4 Adiponectin has insulin-sensitizing, antiinflammatory and antiatherogenic properties; 5 leptin plays an important role in glucose metabolism and acts as a metabolic and neuroendocrine hormone. 6 Decreased adiponectin and increased leptin concentrations are associated with insulin-resistant states. 3,7 Several studies have reported associations between adiponectin/leptin ratios and states with increased insulin resistance A decreased adiponectin/leptin ratio has been shown to be associated with insulin resistance in obesity, 7,8 type 2 diabetes mellitus, 9,10 polycystic ovary syndrome 11 and metabolic syndrome. 12 The significance of the adiponectin/leptin ratio as a potential noninvasive biomarker of insulin resistance in pregnancy remains unknown, however. Thus, the present study evaluated whether the adiponectin/leptin ratio was associated with insulin resistance in pregnancy. Subjects and methods Study Population This was a cross-sectional study conducted between May 2007 and January Women who attended the outpatient clinic at the University Medical Centre Ljubljana, Ljubljana, Slovenia, as part of a standard screening procedure during pregnancy, were enrolled sequentially. Exclusion criteria were: concomitant disease or treatment; use of medications that interfere with insulin resistance; history of previous diabetes mellitus; aged <18 or >45 years. For each participant, data regarding age, week of gestation and prepregnancy weight were collected. Prepregnancy data were collected during routine health checks and were available for all participants. Body height and weight were measured, and body mass index (BMI) before and during pregnancy were calculated. The study protocol was approved by The National Medical Ethics Committee of the Republic of Slovenia, Ljubljana, Slovenia, and the study was conducted in accordance with the Declaration of Helsinki and its amendments. Each study participant provided written informed consent. Glucose, Insulin, Adiponectin and Leptin Measurements For each participant, fasting blood samples were collected into one ethylenediaminetetra-acetic acid (EDTA)-coated tube (1.8 mg of EDTA/ml of blood) and one tube with no additives. Commercially available bloodcollection tubes were used (Becton, Dickinson and Company, Plymouth, UK). The blood samples were centrifuged at 2800 g for 10 min at 4 C. Serum and plasma samples were stored at 80 C until analysis. Plasma glucose concentrations were determined using the standard glucose oxidase method (Beckman Coulter Glucose Analyzer; Beckman Coulter, Brea, CA, USA), according to the manufacturer s instructions. Serum insulin concentrations were measured using a commercially available Immulite Õ 2000 analyser and a chemiluminescent immunoassay kit (Immulite Õ 2000 Insulin; Siemens Healthcare Diagnostics, Camberley, Surrey, UK), according to the manufacturer s instructions. Plasma adiponectin and serum leptin concentrations were measured using commercially available enzyme-linked immunosorbent assay kits (Adiponectin full-length þ globular EIA [44-ADPHU- E01-GLOB] and Leptin EIA [11-LEPHU- E01]; both from ALPCO Diagnostics,
3 125 Skvarca et al. Salem, NH, USA), according to the manufacturer s instructions. Insulin resistance was assessed using HOMA IR, where HOMA IR ¼ (fasting insulin [miu/l] x fasting plasma glucose [mmol/l])/22.5. A HOMA IR score of 2.0 was considered as the cut-off point for insulin resistance. 2 Stastistical Analyses The Shapiro Wilk test was used to assess normality or log normality of the data. Data for normally and log-normally distributed parameters were presented as mean SD. Results for not-normally distributed parameters were presented as median and interquartile range. The correlation between numerical variables was estimated using Pearson s correlation coefficient. Statistical analyses were performed using R language for statistical computing (version 2.8.1). 13 A P-value of <0.05 was considered statistically significant. Results A total of 74 pregnant women were enrolled into the study. Demographic and clinical characteristics for the study participants are presented in Table 1. There was a significant correlation between the HOMA IR and serum leptin concentrations (r ¼ 0.42, 95% confidence interval (CI) 0.21, 0.59; P < 0.01), but no correlation was detected between the HOMA IR and plasma adiponectin concentration (r ¼ 0.19, 95% CI 0.40, 0.04). There was a statistically significant inverse correlation between the HOMA IR and adiponectin/leptin ratio (r ¼ 0.42, 95% CI 0.60, 0.22; P < 0.01 [Figure 1]) and between the adiponectin/leptin ratio and BMI before pregnancy (r ¼ 0.41, 95% CI 0.58, 0.20; P < 0.01). Table 1. Demographic and clinical characteristics of pregnant women assessed for a correlation between the adiponectin/leptin ratio and insulin resistance (n ¼ 74). Characteristic Discussion Value Age, years Gestational age, weeks BMI before pregnancy, kg/m ( ) BMI during pregnancy, kg/m ( ) Fasting glucose concentration, mmol/l Fasting insulin level, miu/l 7.50 ( ) HOMA-IR Adiponectin level, mg/l Leptin level, mg/l Adiponectin/leptin ratio Data presented as mean SD for normally and lognormally distributed parameters, or median (interquartile range) for not-normally distributed parameters. BMI, body mass index; HOMA IR, homeostasis model assessment of insulin resistance. Several studies have investigated the role of the adiponectin/leptin ratio in states with increased insulin resistance The present study investigated the significance of the adiponectin/leptin ratio in pregnancy. A significant inverse correlation was found between the adiponectin/leptin ratio and insulin resistance, using HOMA IR as a reference. Additionally, the serum leptin concentration correlated with HOMA IR, whereas no correlation was found between the adiponectin concentration and HOMA IR. It has been shown that, compared with healthy subjects, adiponectin concentrations are lower in insulin-resistant states such as obesity and type 2 diabetes mellitus. 3 Adiponectin concentrations are also lower in women with gestational diabetes mellitus, compared with those having a normal pregnancy. 14,15 In contrast, higher leptin concentrations have been observed in women
4 Journal of International Medical Research 41(1) 126 Figure 1. Correlation between the homeostasis model assessment of insulin resistance (HOMA IR) and adiponectin/leptin ratio in pregnant women (n ¼ 74); r ¼ 0.42, 95% confidence interval 0.6, 0.22; P < 0.01; Pearson s correlation coefficient. with gestational diabetes mellitus compared with those who have normal glucose tolerance. 15,16 Other studies, however, have found no difference in leptin concentrations between women with gestational diabetes mellitus and those who are having a normal pregnancy, 14 and no correlation between concentrations of adipocytokines (including adiponectin and leptin) and gestational diabetes mellitus. 17 A study performed in obese subjects showed that an increased leptin/adiponectin ratio and increased leptin concentrations, as well as decreased adiponectin concentrations, were associated with insulin resistance in this population. 7 The pregnant women in the present study were not classified as obese (median BMI before pregnancy being kg/m 2 and median BMI during pregnancy being kg/m 2 ) which could explain why no correlations between HOMA IR and adiponectin concentrations were observed. The present study also showed an inverse correlation between the adiponectin/leptin ratio and BMI before pregnancy. This is in accordance with a report indicating that the leptin/adiponectin ratio correlated with BMI and HOMA IR in obese patients. 8 In a study involving a paediatric population,
5 127 Skvarca et al. the leptin/adiponectin ratio was eight-fold greater in obese compared with nonobese children, and showed a stronger correlation with BMI than adiponectin alone. 18 Moreover, the adiponectin/leptin ratio has been shown to correlate with percentage body fat, lipid profile and HOMA IR in a study on metabolic syndrome, 12 and has been described as a sensitive and specific biomarker for metabolic syndrome, 19 as well as an indicator of atherosclerosis. 20 The adiponectin/leptin ratio has been described as a more sensitive and reliable marker of insulin resistance than the HOMA IR, in patients with type 2 diabetes, as fasting plasma glucose concentrations rise. 10 It has also been suggested that, for type 2 diabetic patients, the adiponectin/ leptin ratio may add information beyond that obtained by analysing separate adipocytokines. 21 The present study revealed that the correlation between the leptin concentration and HOMA IR was similar to that between the adiponectin/leptin ratio and HOMA IR. Nevertheless, since pregnant women represent a diverse population, the adiponectin/leptin ratio might be a more reliable marker of insulin resistance than the leptin concentration alone. Studies involving larger populations are required to answer this question. The present study was limited by the fact that the adiponectin/leptin ratio was only compared with insulin resistance as measured by HOMA-IR, not with insulin resistance measured using the euglycaemic hyperinsulinaemic clamp technique (an invasive procedure not generally used in pregnant women). In patients with type 2 diabetes, the adiponectin/leptin ratio correlated better with the clamp technique measurement of insulin resistance than did HOMA IR and other surrogate measures of insulin resistance. 9 A larger study in nondiabetic individuals, performed to investigate correlations between the leptin/adiponectin ratio and measures of insulin resistance (including the euglycaemic hyperinsulinaemic clamp method), revealed the leptin/adiponectin ratio to be a useful measure of insulin resistance. 22 One report suggested that adiponectin and leptin concentrations in pregnancy are influenced by various factors, including placental hormone levels, 23 which were not investigated in the present study. Overall, the results of the present study can be applied to a broader understanding of the significance of adiponectin/leptin ratio in insulin-resistant states. In conclusion, both the adiponectin/ leptin ratio and the leptin concentration correlate with the HOMA IR, in pregnant women. Further studies in larger populations are required, to determine whether the adiponectin/leptin ratio could represent a potential biomarker of insulin resistance in pregnancy, and provide information beyond the HOMA IR. Declaration of Conflicting Interest The authors declare that there are no conflicts of interest. Funding This study was supported by the Slovenian Ministry of Higher Education, Science and Technology, Ljubljana, Slovenia. References 1. Catalano PM, Tyzbir ED, Wolfe RR, et al. Carbohydrate metabolism during pregnancy in control subjects and women with gestational diabetes. Am J Physiol 1993; 264: E60 E Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and b-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28:
6 Journal of International Medical Research 41(1) Weyer C, Funahashi T, Tanaka S, et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 2001; 86: Fasshauer M and Paschke R. Regulation of adipocytokines and insulin resistance. Diabetologia 2003; 46: Lihn AS, Pedersen SB and Richelsen B. Adiponectin: action, regulation and association to insulin sensitivity. Obes Rev 2005; 6: Wauters M, Considine RV and Van Gaal LF. Human leptin: from an adipocyte hormone to an endocrine mediator. Eur J Endocrinol 2000; 143: Tajtakova M, Petrasova D, Pidanicova A, et al. Serum levels of leptin, adiponectin, retinol binding protein 4 and leptin/adiponectin molar ratio as another possible marker of insulin resistance in obese. Bratisl Lek Listy 2010; 111: Kiec -Klimczak M, Malczewska-Malec M and Huszno B. Leptin to adiponectin ratio, as an index of insulin resistance and atherosclerosis development. Przegl Lek 2008; 65: [in Polish, English abstract]. 9. Zaletel J, Barlovic DP and Prezelj J. Adiponectin-leptin ratio: a useful estimate of insulin resistance in patients with Type 2 diabetes. J Endocrinol Invest 2010; 33: Inoue M, Maehata E, Yano M, et al. Correlation between the adiponectin-leptin ratio and parameters of insulin resistance in patients with type 2 diabetes. Metabolism 2005; 54: Xita N, Papassotiriou I, Georgiou I, et al. The adiponectin-to-leptin ratio in women with polycystic ovary syndrome: relation to insulin resistance and proinflammatory markers. Metabolism 2007; 56: Jung CH, Rhee EJ, Choi JH, et al. The relationship of adiponectin/leptin ratio with homeostasis model assessment insulin resistance index and metabolic syndrome in apparently healthy Korean male adults. Korean Diabetes J 2010; 34: R Development Core Team: R: A Language and Environment for Statistical Computing. Vienna: R Foundation for Statistical Computing, 2008 (available at: Retnakaran R, Qi Y, Connelly PW, et al. Low adiponectin concentration during pregnancy predicts postpartum insulin resistance, beta cell dysfunction and fasting glycaemia. Diabetologia 2010; 53: Atègbo JM, Grissa O, Yessoufou A, et al. Modulation of adipokines and cytokines in gestational diabetes and macrosomia. J Clin Endocrinol Metab 2006; 91: Kautzky-Willer A, Pacini G, Tura A, et al. Increased plasma leptin in gestational diabetes. Diabetologia 2001; 44: Skvarca A, Tomazic M, Krhin B, et al. Adipocytokines and insulin resistance across various degrees of glucose tolerance in pregnancy. J Int Med Res 2012; 40: Diamond Jr FB, Cuthbertson D, Hanna S, et al. Correlates of adiponectin and the leptin/adiponectin ratio in obese and nonobese children. J Pediatr Endocrinol Metab 2004; 17: Mirza S, Qu HQ, Li Q, et al. Adiponectin/ leptin ratio and metabolic syndrome in a Mexican American population. Clin Invest Med 2011; 34: E Yun JE, Won S, Mok Y, et al. Association of the leptin to high-molecular-weight adiponectin ratio with metabolic syndrome. Endocr J 2011; 58: Lilja M, Rolandsson O, Norberg M, et al. The impact of leptin and adiponectin on incident type 2 diabetes is modified by sex and insulin resistance. Metab Syndr Relat Disord 2012; 10: Finucane FM, Luan J, Wareham NJ, et al. Correlation of the leptin: adiponectin ratio with measures of insulin resistance in nondiabetic individuals. Diabetologia 2009; 52: Lappas M, Yee K, Permezel M, et al. Release and regulation of leptin, resistin and adiponectin from human placenta, fetal membranes, and maternal adipose tissue and skeletal muscle from normal and gestational diabetes mellitus-complicated pregnancies. J Endocrinol 2005; 186:
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