Debate: HLA matching matters in children
|
|
|
- Pauline Dortha Warner
- 6 years ago
- Views:
Transcription
1 Annual Congress th to 16 th March, the Brighton Centre, Brighton Debate: HLA matching matters in children Presenting the case for - Dr Jon Jin (JJ) Kim, Nottingham
2 Richard & Ronald Herrick 23 Dec 1954 HLA match Good long term survival
3 Graft survival by era
4 Graft survival by HLA MM (deceased donors)
5 Evolution of de novo DSA in children Great Ormond Street Hospital HLA antibody testing Time (mths) C4d Transplant glomerulopathy Kim JJ et al AJT 2014
6 Accept or Not Accept HLA Matching Donor Quality Age Hypertension Cause of death GFR BMI
7 Risk of transplant failure controlled for known confounders The Risk of Transplant Failure With HLA Mismatch in First Adult Kidney Allografts From Deceased Donors Williams, Robert C.; Opelz, Gerhard; McGarvey, Chelsea J.; Weil, E. Jennifer; Chakkera, Harini A. Transplantation100(5): , May doi: /TP Cox multivariate regressions were performed with the survival time of kidney allografts from deceased donors as the dependent variable and HLA mismatch as the primary explanatory variable with 0 mismatch as the reference. Blue diamonds represent the observed HRs for HLA mismatch for a reduced model with age, sex, and transplant era as covariates, whereas the red squares represent the observed HR values for the full model as presented intable 2. The solid blue line is the fitted line for the reduced model with an intercept of 1.02 (0.98, 1.07), P < , and a slope of 0.16 (0.15, 0.17), P < , while the red line is fitted to the full model observed values with intercept of 1.04 (0.98, 1.10), P < , and slope of 0.11 (0.09, 0.12), P < Error bars are the 95% confidence intervals for the respective points on the fitted lines. Copyright 2018 Wolters Kluwer Health, Inc. All rights reserved. 7
8 Scenario 10 yr old Roy PUV, bilateral VUR and dysplasia Crea 600, Urea 33, K6, growth faltering On the waiting list for 3 months Single mum, lorry driver, 3 other kids Uncle, 50 2,2,1 mismatch, blood group compatible Generally fit and well (BMI 29)
9 What to do? LRD from uncle (HD in interim)? Try paired exchange? Something else?
10 HLA mismatch in paediatric living donors HLA Matching in Pediatric Kidney Transplantation: HLA Poorly Matched Living Donor Transplants Versus HLA Well-Matched Deceased Donor Transplants. Opelz G; Dohler B; Middleton D; Susal C; A Collaborative Transplant Study Report Transplantation. 101(11): , 2017 Nov. DOI: /TP FIGURE 1. Influence of HLA-A+B+DR matching on graft survival of first pediatric kidney transplants from LDs performed 2000 to 2015 (log rank P value with trend). Sum of HLA-A, -B, -DR MMs between donor and recipient were added for analysis. Copyright 2017 Wolters Kluwer Health, Inc. All rights reserved. 2
11 Living donor v Deceased donor HLA Matching in Pediatric Kidney Transplantation: HLA Poorly Matched Living Donor Transplants Versus HLA Well-Matched Deceased Donor Transplants. Opelz G; Dohler B; Middleton D; Susal C; A Collaborative Transplant Study Report Transplantation. 101(11): , 2017 Nov. DOI: /TP FIGURE 3. Graft survival of first pediatric kidney transplants. Comparison of well-matched DD grafts (0-1 MM DD) with good (1-3 MM LD) and poorly (4-6 MM LD) matched LD grafts. P values for log rank test of Kaplan- Meier analysis. Copyright 2017 Wolters Kluwer Health, Inc. All rights reserved. 2
12 More detailed HLA matching using Eplets Wiebe JASN
13 Eplet v Antigen matching for HLA-DR and DQ Wiebe JASN
14 Impact of HLA MM on waiting time for 2 nd transplant Foster BJ AJT 2014, doi: /ajt.12643
15 Immunosuppression burden
16 Summary Increased HLA MM directly and proportionally increases the risk of graft failure Deceased Donor and Living Donor Failed transplants with increased MM have higher sensitisation and longer waiting times YES! HLA matching matters in children
17 Remember to look up at the stars and not down at your feet. Try to make sense of what you see and wonder about what makes the universe exist. Be curious. And however difficult life may seem, there is always something you can do and succeed at. It matters that you don t just give up. Stephen Hawking, 1942 ~ 2018
Should red cells be matched for transfusions to patients listed for renal transplantation?
Should red cells be matched for transfusions to patients listed for renal transplantation? Dr M.Willicombe Imperial College Renal and Transplant Centre, Hammersmith Hospital Should red cells be matched
The new Banff vision of the role of HLA antibodies in organ transplantation: Improving diagnostic system and design of clinical trials
The new Banff vision of the role of HLA antibodies in organ transplantation: Improving diagnostic system and design of clinical trials Carmen Lefaucheur 1 2 Banff 2015: Integration of HLA-Ab for improving
Developing a Kidney Waiting List Calculator
Developing a Kidney Waiting List Calculator Jon J. Snyder, PhD* Nicholas Salkowski, PhD, Jiannong Liu, PhD, Kenneth Lamb, PhD, Bryn Thompson, MPH, Ajay Israni, MD, MS, and Bertram Kasiske, MD, FACP *Presenter
Renal Transplant Past Present and Future David Landsberg
2012 Renal Transplant Past Present and Future David Landsberg Outline Changing pattern of Donors Types of Donors Allocation Results Challenges in the Elderly LDPE Transplants By Year LD LRD LUD NDAD DD
Heart Transplant: State of the Art. Dr Nick Banner
Heart Transplant: State of the Art Dr Nick Banner Heart Transplantation What is achieved Current challenges Donor scarcity More complex recipients Long-term limitations Non-specific Pharmacological Immunosuppression
Paired Donation. Andrew Bradley Rachel Johnson Joanne Allen Susan V Fuggle. Cambridge University NHS Hospitals NHS Foundation trust
Paired Donation Andrew Bradley Rachel Johnson Joanne Allen Susan V Fuggle Cambridge University NHS Hospitals NHS Foundation trust Showing a preference 1860 John Calcott Horsley UK Living Donor kidney transplant
The New Kidney Allocation System: What You Need to Know. Anup Patel, MD Clinical Director Renal and Pancreas Transplant Division Barnabas Health
The New Kidney Allocation System: What You Need to Know Anup Patel, MD Clinical Director Renal and Pancreas Transplant Division Barnabas Health ~6% of patients die each year on the deceased donor waiting
Organ transplantation in Bulgaria
Cell Tissue Banking (28) 9:337 342 DOI 1.17/s1561-7-935-2 Organ transplantation in Bulgaria Elissaveta Naumova Æ Petar Panchev Æ Pencho J. Simeonov Æ Anastassia Mihaylova Æ Kalina Penkova Æ Petia Boneva
The New Kidney Allocation Policy: Implications for Your Patients and Your Practice
The New Kidney Allocation Policy: Implications for Your Patients and Your Practice Clinical Practice Today CME Co-provided by Learning Objectives Upon completion, participants should be able to: Explain
CTS Collaborative Transplant Study
CTS Collaborative Transplant Study Newsletter : February, The year marks the th anniversary of the Collaborative Transplant Study. Credit goes to all participants for their contribution to a priceless
LUNG ALLOCATION SCORE SYSTEM UPDATE
LUNG ALLOCATION SCORE SYSTEM UPDATE Current Lung Allocation System System was implemented on May 4, 25 The Lung Allocation Score (LAS) is based on a combination of Expected survival in next year without
A Guide to Better Living
Transplantation What Is a Kidney Transplant? Kidney transplantation is placing a kidney from one person (donor) into a patient with kidney failure (recipient). This is done by surgery where the donated
Predictors of cardiac allograft vasculopathy in pediatric heart transplant recipients
Pediatr Transplantation 2013: 17: 436 440 2013 John Wiley & Sons A/S. Pediatric Transplantation DOI: 10.1111/petr.12095 Predictors of cardiac allograft vasculopathy in pediatric heart transplant recipients
Impact of HLA Mismatch at First Kidney Transplant on Lifetime With Graft Function in Young Recipients
American Journal of Transplantation 2014; 14: 876 885 Wiley Periodicals Inc. C Copyright 2014 The American Society of Transplantation and the American Society of Transplant Surgeons doi: 10.1111/ajt.12643
For broad-split groups where the broad antigen was very rare, we excluded the broad antigen and analyzed each child antigen as their own category.
Description of categorization of broad and split antigens HLA antigen classifications have evolved over time as assay development has allowed the detection of differences in antigens ( split categories)
Corneal transplantation: HLA and age
L Aquila, 24 novembre 2012 Corneal transplantation: HLA and age Federico Genzano Besso*, Paola Magistroni, Piera Santoro*, Silvano Battaglio*, Raffaella Giacometti, Morteza Mansouri and Antonio Amoroso
Steroid Minimization: Great Idea or Silly Move?
Steroid Minimization: Great Idea or Silly Move? Disclosures I have financial relationship(s) within the last 12 months relevant to my presentation with: Astellas Grants ** Bristol Myers Squibb Grants,
James E. Cooper, M.D. Assistant Professor, University of Colorado at Denver Division of Renal Disease and Hypertension, Kidney and PancreasTransplant
James E. Cooper, M.D. Assistant Professor, University of Colorado at Denver Division of Renal Disease and Hypertension, Kidney and PancreasTransplant Program Has no real or apparent conflicts of interest
Chapter 7. Australian Waiting List. ANZDATA Registry 39th Annual Report. Data to 31-Dec-2015
Chapter 7 Australian Waiting List 216 ANZDATA Registry 39th Annual Report Data to 31-Dec-215 Stock and Flow The waiting list data reported here are derived from the Australian National Organ Matching System
NHS BLOOD AND TRANSPLANT CARDIOTHORACIC ADVISORY GROUP URGENT HEART ALLOCATION SCHEMES 2015/2016 ACTIVITY SUMMARY
INTRODUCTION NHS BLOOD AND TRANSPLANT CARDIOTHORACIC ADVISORY GROUP URGENT HEART ALLOCATION SCHEMES 2015/2016 ACTIVITY SUMMARY 1 This paper is a review of the usage of the Adult Urgent Heart Allocation
ORIGINAL ARTICLE. Received April 30, 2007; accepted June
LIVER TRANSPLANTATION 13:1405-1413, 2007 ORIGINAL ARTICLE Human Leukocyte Antigen and Adult Living- Donor Liver Transplantation Outcomes: An Analysis of the Organ Procurement and Transplantation Network
Evaluation of Two New Antibody Detection Techniques in Kidney Transplantation. Doctoral Thesis. Dr. Petra Gombos
Evaluation of Two New Antibody Detection Techniques in Kidney Transplantation Doctoral Thesis Dr. Petra Gombos Semmelweis University Doctoral School of Pathology Supervisor: Dr. Róbert Langer, Ph.D. Consultant:
Welche Donor-spezifischen HLA Antikörper sind schädlich?
Welche Donor-spezifischen HLA Antikörper sind schädlich? Prof. Dr. med. Caner Süsal Transplantationsimmunologie Institut für Immunologie Universität Heidelberg Sensitization Alloantibody Production Alloantibodies
Donor-derived Cell-free DNA Improves DSA-informed Diagnosis of ABMR in Kidney Transplant Patients
Donor-derived Cell-free DNA Improves DSA-informed Diagnosis of ABMR in Kidney Transplant Patients Stanley C. Jordan, MD Director, Division of Nephrology Medical Director, Kidney Transplant Program Medical
Renal Transplantation: Allocation challenges and changes. Renal Transplantation. The Numbers 1/13/2014
Renal Transplantation: Allocation challenges and changes Mark R. Wakefield, M.D., F.A.C.S. Associate Professor of Surgery/Urology Director Renal Transplantation Renal Transplantation Objectives: Understand
We have no disclosures
Pulmonary Artery Pressure Changes Differentially Effect Survival in Lung Transplant Patients with COPD and Pulmonary Hypertension: An Analysis of the UNOS Registry Kathryn L. O Keefe MD, Ahmet Kilic MD,
Diagnosis and Management of Acute and Chronic Humoral Rejection. Lars Pape
Diagnosis and Management of Acute and Chronic Humoral Rejection Lars Pape Immunosuppression Acute rejection Chronic rejection Side effects Infections Nephrotoxicity Adult population Nearly all late rejection-related
Management of Rejection
Management of Rejection I have no disclosures Disclosures (relevant or otherwise) Deborah B Adey, MD Professor of Medicine University of California, San Francisco Kidney and Pancreas Transplant Center
Transplant Nephrology Update: Focus on Outcomes and Increasing Access to Transplantation
Transplant Nephrology Update: Focus on Outcomes and Increasing Access to Transplantation Titte R Srinivas, MD, FAST Medical Director, Kidney and Pancreas Transplant Programs Objectives: Describe trends
Three Sides to Allocation. ECD Extended Criteria Donor
Kidney Allocation- Optimal Use of Deceased Donors The New US System..and impact on wait list management Three Sides to Allocation Justice Peter G Stock MD, PhD Utility Efficiency Standard Criteria Donor
Renal Transplant Registry Report 2008
Renal Transplant Registry Report 28 Contents:. Introduction Page 2. Summary of transplant activity 27-28 Page 2 3. Graft and Patient Survival analysis 989-28 Page 3 4. Acute rejection 989-28 Page 24. Comparison
Literature Review: Transplantation July 2010-June 2011
Literature Review: Transplantation July 2010-June 2011 James Cooper, MD Assistant Professor, Kidney and Pancreas Transplant Program, Renal Division, UC Denver Kidney Transplant Top 10 List: July Kidney
Mary Keogan, on Mary behalf Keogan of all in NHISSOT On behalf of all in NHISSOT. 4th April 2014
Solid Organ Transplantation How the Lab Contributes to Improved Patient Outcomes Mary Keogan, on Mary behalf Keogan of all in NHISSOT On behalf of all in NHISSOT 4th April 2014 Solid Organ Transplantation
DSA Positive and then To biopsy or not?
DSA Positive and then To biopsy or not? Banff SCT 2017 29 March 2017 Peter Nickerson, MD, FRCPC, FCAHS Flynn Family Chair in Renal Transplantation Professor of Internal Medicine and Immunology Relevant
FAIRNESS/EQUITY UTILITY/EFFICACY EFFICIENCY. The new kidney allocation system (KAS) what has it done? 9/26/2018. Disclosures
The new kidney allocation system (KAS) what has it done? Disclosures No financial disclosure Ryutaro Hirose, MD Professor in Clinical Surgery University of California San Francisco Objectives Describe
2017 BANFF-SCT Joint Scientific Meeting. BARCELONA March 2017
2017 BANFF-SCT Joint Scientific Meeting BARCELONA 27-31 March 2017 Adriana Zeevi PhD (D) ABHI Professor of Pathology, Surgery and Immunology Director of Histocompatibility Laboratory University of Pittsburgh
Literature Review Transplantation
Literature Review 2010- Transplantation Alexander Wiseman, M.D. Associate Professor, Division of Renal Diseases and Hypertension Medical Director, Kidney and Pancreas Transplant Programs University of
U.S. changes in Kidney Allocation
U.S. changes in Kidney Allocation Match kidneys with longest survival to patients with longest survival No parallel matching for kidneys with lower survival potential Decrease discard of kidneys with lower
Progress in Pediatric Kidney Transplantation
Send Orders for Reprints to reprints@benthamscience.net The Open Urology & Nephrology Journal, 214, 7, (Suppl 2: M2) 115-122 115 Progress in Pediatric Kidney Transplantation Jodi M. Smith *,1 and Vikas
Current strategies to kidney allocation
Current strategies to kidney allocation Dr Marie Alice Macher Dr Christian Jacquelinet Emilie Savoye Dr Corinne Antoine Direction Prélèvement Greffe organes - tissus From organ sharing to organ allocation
Pediatric Kidney Transplantation
Pediatric Kidney Transplantation Vikas Dharnidharka, MD, MPH Associate Professor Division of Pediatric Nephrology Conflict of Interest Disclosure Vikas Dharnidharka, MD, MPH Employer: University of Florida
Why Do We Need New Immunosuppressive Agents
Why Do We Need New Immunosuppressive Agents 1 Reducing acute rejection rates has not transplanted into better long-term graft survival Incidence of early acute rejection episodes by era Relative risk for
NHS BLOOD AND TRANSPLANT LIVER ADVISORY GROUP WAITING TIMES AND DEATHS ON THE LIST BY BLOOD GROUP SUMMARY
NHS BLOOD AND TRANSPLANT LIVER ADVISORY GROUP WAITING TIMES AND DEATHS ON THE LIST BY BLOOD GROUP BACKGROUND SUMMARY 1 Restrictions in the allocation of livers were introduced in 2006 to reverse the increasingly
Simultaneous Pancreas Kidney Transplantation:
Simultaneous Pancreas Kidney Transplantation: What is the added advantage, and for whom? Alexander Wiseman, M.D. Associate Professor, Division of Renal Diseases and Hypertension Medical Director, Kidney
Epitope matching in solid organ transplantation: T-cell epitopes
Epitope matching in solid organ transplantation: T-cell epitopes Eric Spierings (e.spierings@umcutrecht.nl) Laboratory for Translational Immunology, UMC Utrecht conflict of interest: the UMCU has filed
Le migliori strategie immunosoppressive per il paziente con re-trapianto Prof. Maurizio Salvadori FIRENZE
Le migliori strategie immunosoppressive per il paziente con re-trapianto Prof. Maurizio Salvadori FIRENZE Best Therapy for Kidney Re- Transplantation? PREVENTION!!!! Registries CTS OPTN UNOS USRDS SRTR
Transfusion support in Transplantation
Transfusion support in Transplantation Patricia Campbell University of Alberta Hospitals University of Alberta Objectives UofA transplant programs What we do and why? HLA and ABO incompatible transplants
Article. Simultaneous Pancreas Kidney Transplant versus Other Kidney Transplant Options in Patients with Type 2 Diabetes
Article Simultaneous Pancreas Kidney Transplant versus Other Kidney Transplant Options in Patients with Type 2 Diabetes Alexander C. Wiseman* and Jane Gralla Summary Background and objectives Current organ
Donation from Old Living Donors How safe is it? Safe for recipient or donor?
Donation from Old Living Donors How safe is it? Safe for recipient or donor? Pr Lionel Rostaing Service de Néphrologie, Hémodialyse, Aphérèses et Transplantation CHU Grenoble Alpes France lrostaing@chu-grenoble.fr
NHS BLOOD AND TRANSPLANT KIDNEY OFFERING SCHEME WORKING GROUP ENDORSEMENT OF A NEW NATIONAL KIDNEY OFFERING SCHEME
NHS BLOOD AND TRANSPLANT KIDNEY OFFERING SCHEME WORKING GROUP ENDORSEMENT OF A NEW NATIONAL KIDNEY OFFERING SCHEME INTRODUCTION 1 Three working groups were established to consider whether changes were
SELECTED ABSTRACTS. All (n) % 3-year GS 88% 82% 86% 85% 88% 80% % 3-year DC-GS 95% 87% 94% 89% 96% 80%
SELECTED ABSTRACTS The following are summaries of selected posters presented at the American Transplant Congress on May 5 9, 2007, in San Humar A, Gillingham KJ, Payne WD, et al. Review of >1000 kidney
HLA Part II: My Patient Has DSA, Now What?
2017 CST-Astellas Canadian Transplant Fellows Symposium HLA Part II: My Patient Has DSA, Now What? James Lan, MD, FRCPC, D(ABHI) Dr. Lan completed his nephrology training at the University of British Columbia.
The Kidney Allocation System Changed in a Substantive Way on December 5, Your Patients Have Been, and Will Be, Affected by These Changes
The Kidney Allocation System Changed in a Substantive Way on December 5, 2014 Your Patients Have Been, and Will Be, Affected by These Changes 1 The New Kidney Allocation System Terms of Importance Pediatric
COMPARISON OF THE SURVIVAL OF SHIPPED AND LOCALLY TRANSPLANTED CADAVERIC RENAL ALLOGRAFTS
COMPARISON OF THE SURVIVAL OF SHIPPED AND LOCALLY TRANSPLANTED CADAVERIC RENAL ALLOGRAFTS A COMPARISON OF THE SURVIVAL OF SHIPPED AND LOCALLY TRANSPLANTED CADAVERIC RENAL ALLOGRAFTS KEVIN C. MANGE, M.D.,
Vascular Remodelling in Pancreas Transplantation
Vascular Remodelling in Pancreas Transplantation Prof Steve White Consultant HPB/Transplant Surgeon The Freeman Hospital Newcastle President Elect EPITA European Pancreas Transplants Pancreas Transplants
. Time to transplant listing is dependent on. . In 2003, 9.1% of all prevalent transplant. . Patients with diabetes mellitus are less
Chapter 5: Joint Analyses with UK Transplant in England and Wales; Access to the Renal Transplant Waiting List, Time to Listing, Diabetic Access to Transplantation and the Influence of Social Deprivation
Should Pediatric Patients Wait for HLA-DR-Matched Renal Transplants?
American Journal of Transplantation 2008; 8: 2056 2061 Wiley Periodicals Inc. C 2008 The Authors Journal compilation C 2008 The American Society of Transplantation and the American Society of Transplant
Long-Term Renal Allograft Survival in the United States: A Critical Reappraisal
American Journal of Transplantation 2011; 11: 450 462 Wiley Periodicals Inc. C 2010 The Authors Journal compilation C 2010 The American Society of Transplantation and the American Society of Transplant
Allocation of deceased donor kidneys. Phil Clayton NSW Renal Group 14 June 2012
Allocation of deceased donor kidneys Phil Clayton NSW Renal Group 14 June 2012 Outline Why study kidney allocation? Equity vs utility Current Australian model Previous work in Australia US allocation research
Supporting solid organ transplants: Challenges for Blood Transfusion Labs
Supporting solid organ transplants: Challenges for Blood Transfusion Labs Dora Foukaneli Consultant in Haematology and Transfusion Medicine NHSBT Cambridge and Addenbrooke s Hospital Addenbrooke s Blood
HLA Amino Acid Polymorphisms and Kidney Allograft Survival. Supplemental Digital Content
HLA Amino Acid Polymorphisms and Kidney Allograft Survival Supplemental Digital Content Malek Kamoun, MD, PhD a, Keith P. McCullough, MS b, Martin Maiers, MS c, Marcelo A. Fernandez Vina, MD, PhD d, Hongzhe
Transplant Options for Patients: Choices and Consequences. Olwyn Johnston Medical Director Kidney Transplantation Vancouver General Hospital
Transplant Options for Patients: Choices and Consequences Olwyn Johnston Medical Director Kidney Transplantation Vancouver General Hospital BC Kidney Days October 6 th 2017 Non contributory Conflict of
TA L K I N G A B O U T T R A N S P L A N TAT I O N
TA L K I N G A B O U T T R A N S P L A N TAT I O N Frequently Asked Questions about Kidney Transplant Evaluation and Listing If your kidneys have stopped working properly, or may stop working soon, you
Sylwia Mizia, 1 Dorota Dera-Joachimiak, 1 Malgorzata Polak, 1 Katarzyna Koscinska, 1 Mariola Sedzimirska, 1 and Andrzej Lange 1, 2. 1.
Bone Marrow Research Volume 2012, Article ID 873695, 5 pages doi:10.1155/2012/873695 Clinical Study Both Optimal Matching and Procedure Duration Influence Survival of Patients after Unrelated Donor Hematopoietic
Chronic renal histological changes at implantation and subsequent deceased donor kidney transplant outcomes: a single-centre analysis
Chronic renal histological changes at implantation and subsequent deceased donor kidney transplant outcomes: a single-centre analysis Benedict Phillips 1, Kerem Atalar 1, Hannah Wilkinson 1, Nicos Kessaris
Chronic Kidney Disease (CKD) Stages. CHRONIC KIDNEY DISEASE Treatment Options. Incident counts & adjusted rates, by primary diagnosis Figure 2.
Chronic Kidney Disease (CKD) Stages Stage 1 GFR > 90 (evidence of renal disease) Stage 2 GFR 60-89 Stage 3 GFR 30-59 Stage 4 GFR 15-29 Stage 5 GFR
User Guide. A. Program Summary B. Waiting List Information C. Transplant Information
User Guide This report contains a wide range of useful information about the kidney transplant program at (FLMR). The report has three main sections: A. Program Summary B. Waiting List Information The
Transplantation in highly sensitised patients treated with intravenous immunoglobulin and Rituximab
ORIGINAL ARTICLE Advance Access publication 1 February 2010 Transplantation in highly sensitised patients treated with intravenous immunoglobulin and Rituximab Ana Carina Ferreira 1, Sandra Brum 1, Vasco
Hong Kong Journal Nephrol of 2000;(2): Nephrology 2000;2(2): BR HAWKINS ORIGINAL A R T I C L E A point score system for allocating cadaver
Hong Kong Journal Nephrol of 2000;(2):79-83. Nephrology 2000;2(2):79-83. ORIGINAL A R T I C L E A point score system for allocating cadaveric kidneys for transplantation based on patient age, waiting time
United Kingdom Transplant Activity UK Transplant. Every statisticisaperson.
United Kingdom Transplant Activity 2001 UK Transplant Every statisticisaperson. Cover photograph: Caroline and John Fowler s daughter Aimee, now aged two, shared a donated liver in the first operation
Research Article Computational Approaches to Facilitate Epitope-Based HLA Matching in Solid Organ Transplantation
Hindawi Journal of Immunology Research Volume 2017, Article ID 9130879, 9 pages https://doi.org/10.1155/2017/9130879 Research Article Computational Approaches to Facilitate Epitope-Based HLA Matching in
Obesity has become an epidemic in the United States
Original Clinical ScienceçGeneral Selected Mildly Obese Donors Can Be Used Safely in Simultaneous Pancreas and Kidney Transplantation Tarek Alhamad, MD, MS, 1,2 Andrew F. Malone, MD, 1 Krista L. Lentine,
The New Kidney Allocation System: What You Need to Know. Quality Insights Renal Network 3 Annual Meeting October 2, 2014
The New Kidney Allocation System: What You Need to Know Quality Insights Renal Network 3 Annual Meeting October 2, 2014 Pre Dialysis Era Dialysis Status in USA 500,000 patients on dialysis in 2013 100,000
Table S1. Clinical outcomes of the acceptable mismatch allocation model.
Table S1. Clinical outcomes of the acceptable mismatch allocation model. Recipient Age PRA Waiting Time (months) HLA mismatch (A/B/DR) HLAMatchmaker acceptable mismatch (years) (%) Actual Simulation Change
The Kidney Exchange Problem
100 The UMAP Journal 28.2 (2007) The Kidney Exchange Problem Transplant Network Despite the continuing and dramatic advances in medicine and health technology, the demand for organs for transplantation
When is a child untransplantable?
When is a child untransplantable? Professor Nizam Mamode Guys and St Thomas Hospital Evelina Children s Hospital Great Ormond Street Hospital Page 2 Median waiting time 286 days v 829 days for adults Upper
Information for potential living kidney donors
Feedback We appreciate and encourage feedback. If you need advice or are concerned about any aspect of care or treatment please speak to a member of staff or contact the Patient Advice and Liaison Service
Review Article Clinical Relevance of HLA Antibody Monitoring after Kidney Transplantation
Hindawi Publishing Corporation Journal of Immunology Research Volume 2014, Article ID 845040, 5 pages http://dx.doi.org/10.1155/2014/845040 Review Article Clinical Relevance of HLA Antibody Monitoring
Kidney Allocation- Will it ever be fair? Peter G Stock MD, PhD UCSF Department of Surgery. Would you accept this offer?
Kidney Allocation- Will it ever be fair? Peter G Stock MD, PhD UCSF Department of Surgery Question 1: A 19 y/o deceased donor kidney (O mismatch) from NYC is allocated to a 72 y/o highly sensitized caucasian
Organ Procurement and Transplantation Network
OPTN Organ Procurement and Transplantation Network POLICIES This document provides the policy language approved by the OPTN/UNOS Board at its meeting in June 2015 as part of the Operations and Safety Committee
Donation and Transplantation Kidney Paired Donation Program Data Report
Donation and Transplantation Kidney Paired Donation Program Data Report 2009-2013 Extracts of the information in this report may be reviewed, reproduced or translated for educational purposes, research
Social deprivation, ethnicity and access to kidney transplantation in England and Wales. Udaya Udayaraj
Social deprivation, ethnicity and access to kidney transplantation in England and Wales Udaya Udayaraj Introduction (1) Kidney transplantation Improved survival compared to remaining on dialysis Better
Immunopathology of T cell mediated rejection
Immunopathology of T cell mediated rejection Ibrahim Batal MD Columbia University College of Physicians & Surgeons New York, NY, USA Overview Pathophysiology and grading of TCMR TCMR is still a significant
Acceptable mismatching at the class II epitope level: the Canadian experience
REVIEW C URRENT OPINION Acceptable mismatching at the class II epitope level: the Canadian experience Chris Wiebe a and Peter Nickerson a,b Purpose of review To summarize the evidence concerning human
National Transplant Guidelines
National Transplant Guidelines Quo Vadis? Scott Campbell, Princess Alexandra Hospital, Brisbane. Quo Vadis Whither goest thou? Where the F#$% do we go next? Overview WAITING LIST ELIGIBILITY ALLOCATION
Compared efficacy of preservation Solutions in liver transplantation: a long-term graft outcome study from the European Liver Transplant Registry.
12/2013 Compared efficacy of preservation Solutions in liver transplantation: a long-term graft outcome study from the European Liver Transplant Registry. René ADAM, Valérie DELVART, Vincent KARAM, Christian
Article. HLA-DQ Mismatches and Rejection in Kidney Transplant Recipients
Article HLA-DQ Mismatches and Rejection in Kidney Transplant Recipients Wai H. Lim,* Jeremy R. Chapman, Patrick T. Coates, Joshua R. Lewis, Graeme R. Russ, Narelle Watson, Rhonda Holdsworth,** and Germaine
Desensitization in Kidney Transplant. James Cooper, MD Assistant Professor, Kidney and Pancreas Transplant Program, Renal Division, UC Denver
Desensitization in Kidney Transplant James Cooper, MD Assistant Professor, Kidney and Pancreas Transplant Program, Renal Division, UC Denver Organ Shortage Currently there are >90,000 patients on the kidney
Aetiology versus Prediction - correct for Confounding? Friedo Dekker ERA-EDTA Registry / LUMC
Aetiology versus Prediction - correct for Confounding? Friedo Dekker ERA-EDTA Registry / LUMC Aetiology Study effect of a risk factor on an outcome Consider potential confounding: other risk factor for
Short-term and Long-term Survival of Kidney Allograft Cure Model Analysis
TRANSPLANTATION Short-term and Long-term Survival of Kidney Allograft Cure Model Analysis Moghaddameh Mirzaee, 1 Jalal Azmandian, 2 Hojjat Zeraati, 1 Mahmood Mahmoodi, 1 Kazem Mohammad, 1 Abbas Etminan,
Future Webinars. Handouts 18/09/ Program-Handouts.aspx
Transplant Webinar Series: Ep. 9 Bio for Post-Transplant Immune Injury Future Webinars Link to register: https://immucor.webinato.com/register All Content 215 Immucor, Inc. Handouts http://www.immucor.com/en-us/pages/educational-
Summary of Significant Changes. Policy
This Policy replaces POL186/2 Copy Number Effective 01/04/14 Summary of Significant Changes Clarification of policy approval process Paragraph 2.2.1 Clarification of Kidney Fast Track Scheme offering criteria
Embracing the Magic: Increasing Organ Acceptance Rates Through Data Review and Risk Stratification
Embracing the Magic: Increasing Organ Acceptance Rates Through Data Review and Risk Stratification Presented by: Sandy Felty, RN, MSN, MHA Lynette Martin del Campo, RN, MSN, FNP-C Sharon Norfles, RN, BSN
Kidney transplantation 2016: current status and potential challenges
Kidney transplantation 2016: current status and potential challenges 15/12/2016 BVN-SBN : State-of-the-Art on Kidney Transplantation Patrick Peeters Ghent University Hospital, Belgium Challenges in 2016
The Banff Classification for Diagnosis of Renal Allograft Rejection: Updates from the 2017 Banff Conference
The Banff Classification for Diagnosis of Renal Allograft Rejection: Updates from the 2017 Banff Conference Mark Haas Cedars-Sinai Medical Center Los Angeles, California, USA Statement of Disclosure Mark
Cover Page. The handle holds various files of this Leiden University dissertation.
Cover Page The handle http://hdl.handle.net/1887/29755 holds various files of this Leiden University dissertation. Author: Moes, Dirk Jan Alie Roelof Title: Optimizing immunosuppression with mtor inhibitors
Transplant Applications of Solid phase Immunoassays Anti HLA antibody testing in solid organ transplantation
AACC Professional Course BETH ISRAEL DEACONESS MEDICAL CENTER HARVARD MEDICAL SCHOOL Transplant Applications of Solid phase Immunoassays Anti HLA antibody testing in solid organ transplantation J. Ryan
Transplant Webinar Series: Ep. 9 Biomarkers for Post-Transplant Immune Injury
Transplant Webinar Series: Ep. 9 Biomarkers for Post-Transplant Immune Injury Future Webinars Link to register: https://immucor.webinato.com/register All Content 2015 Immucor, Inc. Handouts http://www.immucor.com/en-us/pages/educational-
New Zealand Kidney Allocation Scheme
New Zealand Kidney Allocation Scheme The New Zealand Kidney Allocation Scheme (NZKAS) has been developed to ensure that kidney allocation in NZ is performed on an equitable, accountable and transparent
Risk Factors in Long Term Immunosuppressive Use and Advagraf. Daniel Serón Nephrology department Hospital Universitari Vall d Hebron
Risk Factors in Long Term Immunosuppressive Use and Advagraf Daniel Serón Nephrology department Hospital Universitari Vall d Hebron Progressive well defined diseases ABMR GN Polyoma Non-specific Findings