Nephrogram type. Days between first and second NCCT
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1 Supplemental Table 1. Characteristics of patients with multiple unenhanced CT scans number Contrastenhanced procedure Pre-CE exam egfr present at first NCCT type Days between first and second NCCT present at second NCCT Negative patient outcome 1 Cath 52 Yes Cortical 4.4 No None 2 Cath 83 Yes Global/Focal 1.2 No None 3 Cath 36 Yes Global 12.6 No None 4 Cath 41 Yes Cortical 8.4 No AKI 5 Cath 18 Yes Global 5.5 No AKI, dialysis 6 Cath 43 No No AKI, dialysis 7 Cath 28 No No None 8 Cath 37 No No None 9 Cath 72 No No None 10 CECT 68 Yes Cortical 4.6 No AKI, dialysis, died 11 CECT 65 No No None 12 CECT 57 No No None 13 CECT 61 No No None 14 CECT 102 No No None 15 CECT 73 No No AKI, dialysis
2 Supplemental Table 2. Characteristics of patients and procedures with and without faint to moderate bilateral global nephrograms (HU>55) * No Number 28 (25%) 82 Age (median, IQR) 75 (62-80) 70 (56-77) 1.03 ( ).07 Female (%) 16 (57%) 38 (46%) 1.54 ( ).38 Diabetes mellitus 4 (14%) 4 (4.9%) 3.25 ( ).20 Chronic kidney disease 13 (46%) 23 (28%) 2.22 ( ).10 Nephrectomy or atrophic kidney 2 (7.1%) 3 (3.7%) 2.03 ( ).44 Kidney transplant 1 (3.6%) 4 (4.9%) 0.72 ( ).99 Acute kidney injury (history of) 0 4 (4.9%) -.57 Acute kidney injury 2 (7.1%) 5 (6.1%) 1.18 ( ).99 Acute hypotension/shock 8 (29%) 9 (11%) 3.24 ( ).0357 Pre- egfr 51 (33-68) 70 (56-91) 0.97 ( ) <.001 Pre- egfr subgroups > 60 ml/min/1.73 m 2 9 (32%) 56 (68%) ml/min/1.73 m 2 16 (57%) 23 (28%) < 30 ml/min/1.73 m 2 3 (11%) 3 (3.7%) CT 12 (22%) 43 (78%) 0.68 ( ).51** Cardiac catheterization 16 (29%) 39 (71%) Diagnostic catheterization 5 (17%) 25 (83%) 3.93 ( ).04*** Interventional catheterization 11 (44%) 14 (56%) Contrast dose (g I/kg) 0.43 ( ) 0.43 ( ) 0.70 ( ).75 **Comparing nephrogram proportions between CT versus catheterization recipients. ***Comparing nephrogram proportions between interventional versus diagnostic catheterization recipients.
3 Supplemental Table 3. Characteristics of patients and procedures with and without moderate to marked bilateral global nephrograms (HU>100) * No Number 6 (5.5%) 104 Age (median, IQR) 77 (70-80) 71 (57-78) 1.04 ( ).23 Female (%) 2 (33%) 52 (50%) 0.50 ( ).68 Diabetes mellitus 0 8 (7.7%) -.99 Chronic kidney disease 2 (33%) 34 (33%) 1.03 ( ).99 Nephrectomy or atrophic kidney 1 (17%) 4 (3.9%) 5.00 ( ).25 Kidney transplant 0 5 (4.8%) -.99 Acute kidney injury (history of) 0 4 (3.9%) -.99 Acute kidney injury 0 7 (6.7%) -.99 Acute hypotension/shock 3 (50%) 14 (13%) 6.43 ( ).05 Pre- egfr 60 (30-75) 65 (50-86) 0.98 ( ).30 Pre- egfr subgroups -.46 > 60 ml/min/1.73 m 2 3 (50%) 62 (60%) ml/min/1.73 m 2 2 (33%) 37 (36%) < 30 ml/min/1.73 m 2 1 (17%) 5 (4.8%) CT 2 (3.6%) 53 (96%) 0.48 ( ).68** Cardiac catheterization 4 (7.3%) 51 (93%) Diagnostic catheterization 1 (3.3%) 29 (97%) 3.95 ( ).32*** Interventional catheterization 3 (12%) 22 (88%) Contrast dose (g I/kg) 0.49 ( ) 0.43 ( ) 9.18 ( ).30 **Comparing nephrogram proportions between CT versus catheterization recipients. ***Comparing nephrogram proportions between interventional versus diagnostic catheterization recipients.
4 Supplemental Table 4. Characteristics of patients and procedures with and without bilateral global nephrograms following CECT * No Number 19 (32%) 41 Odds Ratio (95% CI) Age (median, IQR) 68 (54-75) 68 (54-75) 1.03 ( ).18 Female (%) 10 (53%) 20 (49%) 1.17 ( ).99 Diabetes mellitus 3 (16%) 2 (4.9%) 3.65 ( ).31 Chronic kidney disease 10 (53%) 9 (22%) 3.95 ( ).03 Nephrectomy or atrophic kidney 0 1 (2.4%) -.99 Kidney transplant 0 2 (4.9%) -.99 Acute kidney injury (history of) 0 2 (4.9%) -.99 Acute kidney injury 2 (11%) 2 (4.9%) 2.29 ( ).58 Acute hypotension/shock 5 (26%) 4 (9.8%) 3.30 ( ).13 Pre- egfr 65 (49-85) 78 (64-100) 0.98 ( ).04 Contrast dose (g I/kg) 0.44 ( ) 0.45 ( ) 0.10 (0-34.4).40
5 Supplemental Table 5. Characteristics of patients and procedures with and without bilateral global nephrograms following cardiac catheterization * No Number 27 (43%) 36 Age (median, IQR) 79 (69-82) 70 (59-77) 1.06 ( ).01 Female (%) 17 (63%) 16 (44%) 2.13 ( ).20 Diabetes mellitus 2 (7.4%) 2 (5.6%) 1.36 ( ).99 Chronic kidney disease 10 (37%) 11 (31%) 1.34 ( ).60 Nephrectomy or atrophic kidney 1 (3.7%) 3 (8.3%) 0.42 ( ).63 Kidney transplant 0 3 (8.3%) -.25 Acute kidney injury (history of) 1 (3.7%) 2 (5.6%) 0.65 ( ).99 Acute kidney injury 2 (7.4%) 3 (8.3%) 0.88 ( ).99 Acute hypotension/shock 7 (26%) 3 (8.3%) 3.85 ( ).08 Pre- egfr 52 (35-67) 61 (50-79) 0.99 ( ).11 Diagnostic (vs. PCI) 9 (33%) 24 (67%) 0.25 ( ).01 Femoral (vs. radial) 23 (85%) 33 (92%) 0.52 ( ).42 LVEF (%) 50 (36-60) 60 (51-65) 0.97 ( ).04 Total fluoroscopy time 18 (8-29) 9 (5-23) 1.04 ( ).02 Contrast dose (g I/kg) 0.43 ( ) 0.22 ( ) 16.0 ( ).07
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